StudyFinder
Search Results
630 Study Matches
Role of Circadian Factors in Inflammation and Colorectal Adenoma Risk
Shetty, Shreya - shettysa@vcu.edu
Burch, James
17947
HM20021857
Rectum, Colon
Longitudinal Cohort Registry of Cancer Survivors
Hong, Susan - susan.hong@vcuhealth.org
Hong, Susan
17880
HM20021510
Anus, Any Site, Bones and Joints, Breast, Brain and Nervous System, Other Hematopoietic, Other Female Genital, Other Endocrine System, Other Digestive Organ, Non-Hodgkin's Lymphoma, Myeloid and Monocytic Leukemia, Mycosis Fungoides, Multiple Myeloma, Melanoma, skin, Lymphoid Leukemia, Lung, Liver, Lip, Oral Cavity and Pharynx, Leukemia, other, Leukemia, Not Otherwise Specified, Larynx, Kidney, Kaposi's sarcoma, Ill-Defined Sites, Hodgkin's Lymphoma, Eye and Orbit, Esophagus, Corpus Uteri, Colon, Cervix, Other Male Genital, Other Respiratory and Intrathoracic Organs, Other Urinary, Urinary Bladder, Thyroid, Stomach, Soft Tissue, Small Intestine, Rectum, Prostate, Pancreas, Ovary, Other Skin
Multiplex Analysis of Venetoclax Sensitivity in Patients Diagnosed with AML or CLL
Lantis, Kristin - kllantis@vcu.edu
Grant, Steven
17581
HM20020962
Myeloid and Monocytic Leukemia, Lymphoid Leukemia
The Impact of Sarcopenia in Patients with Cirrhosis
Evans, Marie-Claire - marieclaire.evans@vcuhealth.org
Siddiqui, Mohammad, S
18741
HM20019626
Diseases of Digestive System (520-579)
Impacts of COVID-19 on Cigarette Smoking Behaviors
ctrrecruit@vcu.edu
Breland, Alison
19171
HM20019258
Any Site
Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT
Suna Chung, MPH - schung60@jhu.edu
Kates, Stephen, L
NCT04678154
HM20022236
Inclusion Criteria:
• Injury meeting at least one of the following criteria: * Gustilo type III tibia (OTA 41 plateau, OTA 42 shaft and OTA 43 pilon) requiring a second procedure for final debridement and definitive coverage / closure following the index stabilization * Gustilo type IIIB ankle fractures (OTA 44) * Gustilo type IIIB calcaneus fractures (OTA 82) * Gustilo type IIIB talus fractures (OTA 81) * Traumatic "zone-of-injury" trans-tibial amputations requiring DPC, and/or flap coverage
• Ages 18 - 64 years inclusive
• Patients may have risk factors for infection including diabetes, immunosuppression from steroids or other medications, HIV, or other infections.
• Patients may have a traumatic brain injury.
• Patients may have other fractures including spine, upper extremity fractures, contralateral lower extremity injuries, ipsilateral pelvis, hip, femur or foot injuries.
• Patients may be treated initially at an outside institution prior to transfer to the study institution, as long as the definitive wound closure or coverage was not performed prior to entrance into the study.
• Patients with bilateral injuries that meet inclusion criteria may be included, but only the limb rated as "more severe" by the treating surgeon will be enrolled in the study.
• Patients may have co-existing non-tibial or hindfoot infection, with or without antibiotic treatment.
• Patients may be definitively stabilized using any method (nail, plate, ex fix or cast).
• Patients may have a fasciotomy.
Exclusion Criteria:
• Patient in current therapy for a wound, implant or fracture site infection related to the study site.
• Patient likely to have difficulty maintaining follow-up, including: * Diagnosis of a severe psychiatric condition * Intellectually challenged without adequate family support * Resides outside of the hospital's catchment area * Planning to follow-up at another medical center * Being a prisoner * Not having a means of contact (address, cell phone, home phone, e-mail)
DRUG: Standard of care, DRUG: Vancomycin and Tobramycin
Post Operative Surgical Site Infection
Surgical site infection risk prevention, Bacterial species type and antibacterial sensitivities
Observational - Characteristics, Treatment, Outcomes -Severe Asthma in the US (CHRONICLE)
Toft, Robin - robin.toft@vcuhealth.org
Mohan, Arjun
NCT03373045
HM20022693
Modality: No vcuhs billing
Diseases of Respiratory System (460-519)
Efficacy/Safety SPR001 (Tildacerfont) Reducing Supraphysiologic Glucocorticoid Use in Adults w CAH
Memoli, Erica, H - erica.memoli@vcuhealth.org
Gupta, Anshu
NCT04544410
HM20019420
drug: Spr001 (tildacerfont)
Endocrine, Nutritional, Metabolic Diseases, Immunity Disorders (240-279)
Efficacy/Safety of SPR001 (Tildacerfont) in Adults with Classic Congenital Adrenal Hyperplasia
Memoli, Erica, H - erica.memoli@vcuhealth.org
Gupta, Anshu
NCT04457336
HM20019413
drug: Spr001 (tildacerfont)
Endocrine, Nutritional, Metabolic Diseases, Immunity Disorders (240-279)
Efficacy of EsoGuard on Samples Collected Using EsoCheck Versus EGD for the Diagnosis of BE
Coleman, PARIS - paris.coleman@vcuhealth.org
Smallfield, George, B
NCT04293458
HM20018839
Diseases of Digestive System (520-579)
Phase Ib/II of ARRY-614 plus either nivolumab or nivolumab+ipilimumab in advanced solid tumors
Osipova, Ekaterina - osipovak@vcu.edu
Poklepovic, Andrew, S
NCT04074967
HM20021810
drug: Nivolumab,
drug: Ipilimumab,
drug: Arry-614, Modality: Immunotherapy
Melanoma, skin, Other Urinary, Urinary Bladder, Thyroid, Stomach, Soft Tissue, Small Intestine, Rectum, Prostate, Pancreas, Ovary, Other Respiratory and Intrathoracic Organs, Other Male Genital, Other Female Genital, Other Endocrine System, Other Digestive Organ, Lung, Liver, Lip, Oral Cavity and Pharynx, Larynx, Kidney, Eye and Orbit, Ill-Defined Sites, Esophagus, Corpus Uteri, Colon, Cervix, Breast, Brain and Nervous System, Bones and Joints
A Study to Assess the Efficacy and Safety of VK2809 for 52 Weeks in Subjects With Biopsy Proven NASH (VOYAGE)
Hurst, Caitlin - hurstc3@vcu.edu
Sanyal, Arun, J
NCT04173065
HM20018948
drug: Vk2809
Diseases of Digestive System (520-579)
Efficacy, Safety, and Tolerability of Efgartigimod PH20 SC in Adult with CIDP (ADHERE)
Smith, LaVon - lavon.smith@vcuhealth.org
Gwathmey, Kelly
NCT04281472
HM20018410
drug: Argx-113
Diseases of Nervous System and Sense Organs (320-389)
The Effect of Electronic Cigarette Liquid Characteristics in Smokers.
Breland, Alison - abbrelan@vcu.edu
Eissenberg, Thomas, E
NCT03861078
HM20015258
Lung
Safety Study of Etripamil Nasal Spray for Patients With Paroxysmal Supraventricular Tachycardia
Sami, Aysha, V - Aysha.Sami@vcuhealth.org
Ellenbogen, Kenneth, A
NCT04072835
HM20018724
drug: Etripamil
Diseases of Circulatory System (390-459)
Improving Communication and Adherence in Black Breast Cancer Survivors (SIS) (SISTERS)
Cummings, Yvonne - yvonne.cummings@vcuhealth.org
Sheppard, Vanessa, B.
NCT05334732
HM20016396
Breast
Efficacy and Safety of Benralizumab vs Mepolizumab in Treatment of EGPA (MANDARA) (MANDARA)
ctrrecruit@vcu.edu
Ward, Brant
NCT04157348
HM20018295
drug: Mepolizumab,
drug: Benralizumab
Diseases of Circulatory System (390-459)
A Clinical Study to Evaluate the Efficacy and Safety of Aramchol in Subjects With NASH (ARMOR)
Lindemuth, Margaret (Maggie) - margaret.lindemuth@vcuhealth.org
Siddiqui, Mohammad, S
NCT04104321
HM20018490
drug: Aramchol
Diseases of Digestive System (520-579)
Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial (COSMID)
Kelsey M Pullar, MPH - kpullar@uw.edu
Wieghard, Nicole
NCT04095663
HM20016794
Inclusion Criteria:
* Adults ≥18 years
* At least one episode of diverticulitis confirmed by CT scan and a colonoscopy (completed or scheduled) to rule out or screen for other colon pathology in accordance with colorectal cancer screening guidelines
* Persistent signs, symptoms, or concerns related to diverticulitis after recovery from an episode of left-sided diverticulitis
* Self-reported QoL limitation (assessed with 12 questions modified from the Diverticulitis Quality of Life \[DV-QOL\] instrument).
Exclusion Criteria:
* Unable to consent in English or Spanish
* Current diagnosis or previous endoscopic or surgical interventions for fistula, or stricture or current significant bleeding, related to diverticulitis
* Last episode of acute diverticulitis currently unresolved (i.e., on antibiotics for diverticulitis; drain in place)
* Previous operation for diverticulitis
* Right-sided diverticulitis
* Immunodeficiency (e.g., absolute neutrophil count \<500/mm3, chronic immunosuppressive drugs like oral corticosteroids, anti-TNF agents, or known AIDS \[i.e., recent CD4 count \<200\] assessed by patient history)
* Actively undergoing chemotherapy or radiation for malignancy
* Expectant or concurrent hemodialysis, peritoneal dialysis, treatments using indwelling venous catheters, or conditions putting patient at risk for bacterial seeding
* Diagnosis of inflammatory bowel disease (i.e., Crohn's, ulcerative colitis)
* Taking prescription medication for irritable bowel syndrome
* Intolerance or allergy to all medications in the medical management arm
* Surgeon is unwilling to offer surgery due to comorbid or prior surgical conditions that contraindicate elective surgery (e.g., liver failure, renal failure, malignancy, "frozen abdomen")
* Abdominal/pelvic surgery within the past month
* Pregnant or expecting to become pregnant in the 30 days following baseline/screening
* Unable to consent to research or self-respond to follow-up surveys (e.g., altered mental status)
* Currently incarcerated in a detention facility or in police custody at baseline/screening (patients wearing a monitoring device can be enrolled)
* Prior enrollment in the COSMID study or planning on enrollment in another investigational drug or vaccine while on study treatment
* Unable or unwilling to return, be contacted for, or complete research surveys. PROCEDURE: Partial Colectomy, OTHER: Medical Management
Diverticulitis
Safety and Immunogenicity of GSK Meningococcal Group B Vaccine and 13-valent Pneumococcal Vaccine
Lessard, Margaret "Meg" - margaret.lessard@vcuhealth.org
Meloy, Linda
NCT03621670
HM20014721
drug: Rmenb+omv nz,
drug: Pcv13
DSC-MRI in Measuring Cerebral Blood Volume for Early Response to Bevacizumab in Recurrent GBM
Hess, Alison - ahess2@vcu.edu
Chen, Zhi-Jian
NCT03115333
HM20021895
Brain and Nervous System
Validating Cell-Based Assays for ABMR After Renal Transplantation (CBA ABMR)
Baldecchi, Mary - mary.baldecchi@vcuhealth.org
Gupta, Gaurav
NCT03916822
HM20019307
Diseases of Genitourinary System (580-629)
Study of Aldafermin (NGM282) in Subjects With Compensated Cirrhosis (ALPINE 4) (ALPINE4)
Lindemuth, Margaret (Maggie) - margaret.lindemuth@vcuhealth.org
Siddiqui, Mohammad, S
NCT04210245
HM20019792
drug: Ngm282
Diseases of Digestive System (520-579)
Flexible-Dose, Adjunctive Therapy Trial in Adults With Parkinson s Disease With Motor Fluctuations
Norris, Virginia "Ginger" - virginia.norris@vcuhealth.org
Cloud, Leslie
NCT04542499
HM20019622
drug: Tavapadon (cvl-751)
Diseases of Nervous System and Sense Organs (320-389)
Phase II - Long-term Safety and Efficacy in Adults With CDIP (ADHERE+) (ADHERE+)
Smith, LaVon - lavon.smith@vcuhealth.org
Gwathmey, Kelly
NCT04280718
HM20018942
drug: Argx-113
Diseases of Nervous System and Sense Organs (320-389)
Efgartigimod Expanded Access for Generalized Myasthenia Gravis
Wilkins, Bridget - bridget.wilkins@vcuhealth.org
Gwathmey, Kelly
NCT04777734
HM20022105
Diseases of Nervous System and Sense Organs (320-389)
Long-Term Safety and Efficacy Outcomes - Previously Administered SHP607 -Extremely Premature Infants
Lessard, Margaret "Meg" - margaret.lessard@vcuhealth.org
Rozycki, Henry
NCT04506619
HM20022198
Certain Conditions Originating in the Perinatal Period (760-779)
Study in PD Patients With Dyskinesia With Combinations of JM-010 and Its Individual Components
Blackwell, Gina, M - gina.blackwell@vcuhealth.org
Cloud, Leslie
NCT04377945
HM20021757
drug: Jm-010,
drug: Buspirone,
drug: Zolmitriptan
Diseases of Nervous System and Sense Organs (320-389)
Saroglitazar Magnesium for the Treatment of Nonalcoholic Steatohepatitis with Fibrosis
Patel, Falgun - falgun.patel@vcuhealth.org
Siddiqui, Mohammad, S
NCT05011305
HM20021644
drug: Saroglitazar magnesium
Diseases of Digestive System (520-579)
Phase 2B, Randomized, Double-Blind, Placebo-Controlled - Safety/ Efficacy of Efruxifermin - NASH
Edwards, Megan, C - megan.edwards@vcuhealth.org
Siddiqui, Mohammad, S
NCT04767529
HM20021459
drug: Efruxifermin
Diseases of Digestive System (520-579)