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Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT) (KESETT)
Megan Wardius - mew5j@virginia.edu
NCT06907173
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Inclusion Criteria:
* The patient was witnessed to have a convulsive seizure for greater than 5-minute duration
* The patient received an adequate dose of benzodiazepines. The doses may be divided.
* The last dose of a benzodiazepine was administered 5-30 minutes before study drug administration.
* Continued or recurring seizures in the Emergency Department.
* Age 1 years or older
* Known or estimated weight ≥10 Kg
Exclusion Criteria:
* Known pregnancy
* Prisoner
* Opt-out identification or otherwise known to be previously enrolled in KESETT
* Treatment with a second line anticonvulsant (FOS, PHT, VPA, LEV, phenobarbital, or other agents defined in the MoP) for this episode of SE
* Treatment with sedatives with anticonvulsant properties other than benzodiazepines for this episode of SE(propofol, etomidate, ketamine or other agents defined in the MoP)
* Endotracheal intubation prior to enrollment
* Acute traumatic brain injury clearly precedes seizures
* Scalp injury or burn preventing EEG placement
* Known allergy or other known contraindication to KET or LEV
* Hypoglycemia \< 50 mg/dL
* Hyperglycemia \> 400 mg/dL
* Cardiac arrest / post-anoxic seizures DRUG: Levetiracetam (LEV) (60 mg/Kg) + 1 mg/kg Ketamine (KET), DRUG: Levetiracetam (LEV) (60 mg/Kg) + 3 mg/kg Ketamine (KET), DRUG: Levetiracetam (LEV) (60 mg/Kg)
Status Epilepticus
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Study Locations
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| Location | Contacts |
|---|---|
| Arthur M. Blank Hospital Atlanta, Georgia | Claudia Morris, MD - (claudia.r.morris@emory.edu) |
| Banner University Medical Center - Tucson Campus Tucson, Arizona | Aaron Leetch, MD - (aleetch@arizona.edu) |
| Children's Hospital Los Angeles Los Angeles, California | Ara Festekjian, MD - (afestekjian@chla.usc.edu) |
| Children's Hospital of Wisconsin Milwaukee, Wisconsin | Keli Coleman, MD - (kcoleman@mcw.edu) |
| Children's Medical Center Dallas Dallas, Texas | Pamela Okada, MD - (pamela.okada@utsouthwestern.edu) |
| Children's National Medical Center Washington D.C., District of Columbia | James Chamberlain, MD - (jchamber@childrensnational.org) |
| Christiana Hospital Newark, Delaware | Jason Nomura, MD - (jnomura@christianacare.org) |
| Comer Children's Hospital Chicago, Illinois | David Beiser, MD - (dbeiser@medicine.bsd.uchicago.edu) |
| Detroit Receiving Hospital Detroit, Michigan | Wazim Mohamed, MD - (wmohamed@med.wayne.edu) |
| Duke Regional Hospital Durham, North Carolina | Alexander Limkakeng, MD - (alexander.limkakeng@duke.edu) |
| Duke University Hospital Durham, North Carolina | Alexander Limkakeng, MD - (alexander.limkakeng@duke.edu) |
| Froedtert Hospital Milwaukee, Wisconsin | Jamie Jasti, MD - (jjasti@mcw.edu) |
| Grady Memorial Hospital Delaware, Ohio | Jonathan Ratcliff, MD, MPH - (jonathan.ratcliff@emoryhealthcare.org) |
| Harborview Medical Center Seattle, Washington | Vasisht Srinivasan, MD - (vasishts@uw.edu) |
| Hennepin County Medical Center Minneapolis, Minnesota | Brian Driver, MD - (brian.driver@hcmed.org) |
| Henry Ford Hospital Detroit, Michigan | Joseph Miller, MD - (jmiller6@hfhs.org) |
| Hospital of the University of Pennsylvania Philadelphia, Pennsylvania | John Greenwood, MD - (john.greenwood@pennmedicine.upenn.edu) |
| IU Health Methodist Hospital Indianapolis, Indiana | Daniel Udrea, MD - (dudrea@iu.edu) |
| Jefferson Einstein Philadelphia Hospital Philadelphia, Pennsylvania | Joseph Herres, DO - (Joseph.herres@jefferson.edu) |
| Massachusetts General Hospital Boston, Massachusetts | Michael Filbin, MD - (mfilbin@mgh.harvard.edu) |
| Memorial Hermann Texas Medical Center Houston, Texas | Kayleigh Fischer, MD - (Kayleigh.A.Fischer@uth.tmc.edu) |
| Nationwide Children's Hospital Columbus, Ohio | Aarti Gaglani Aarti Gaglani, MD - (kesett@nationwidechildrens.org) |
| Nemours Children's Hospital Orlando, Florida | Amy Thompson, MD - (amy.thompson@nemours.org) |
| Northwestern Memorial Hospital Chicago, Illinois | Peter Pruitt, MD - (peter.pruitt@nm.org) |
| Oregon Health & Science University Hospital Portland, Oregon | Bory Kea, MD - (kea@ohsu.edu) |
| Orlando Regional Medical Center Orlando, Florida | Dipali Nemade, MD - (Dipali.Nemade@orlandohealth.com) |
| Primary Children's Hospital Salt Lake City, Utah | Maija Holsti, MD, MPH - (Maija.Holsti@hsc.utah.edu) |
| Reading Hospital West Reading, Pennsylvania | Adam Sigal, MD - (adam.sigal@towerhealth.org) |
| Riley Hospital for Children Indianapolis, Indiana | Benjamin Nti, MD - (bnti@iu.edu) |
| Ronald Reagan UCLA Medical Center Los Angeles, California | Richelle Cooper, MD - (rcooper@mednet.ucla.edu) |
| SUNY Upstate Medical University Syracuse, New York | Lindsay Nausin, DO - (nausinl@upstate.edu) |
| San Francisco General Hospital San Francisco, California | Debbie Madhok, MD - (Debbie.madhok@ucsf.edu) |
| Temple University Hospital Philadelphia, Pennsylvania | Derek Isenberg, MD - (derek.isenberg@tuhs.temple.edu) |
| UC Davis Medical Center Sacramento, California | Daniel Nishijima, MD - (dnishijima@ucdavis.edu) |
| UPMC Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania | Robert Hickey, MD - (robert.hickey@chp.edu) |
| UPMC Presbyterian Hospital Pittsburgh, Pennsylvania | Adam Frisch, MD - (frischan@upmc.edu) |
| University of Chicago Medical Center Chicago, Illinois | David Beiser, MD - (dbeiser@medicine.bsd.uchicago.edu) |
| University of Cincinnati Medical Center Cincinnati, Ohio | Jason McMullan, MD - (jason.mcmullan@uc.edu) |
| University of Iowa Medical Center Iowa City, Iowa | Brett Faine, MD - (brett-faine@uiowa.edu) |
| University of Maryland Medical Center Baltimore, Maryland | Jennifer Hopp, MD - (jhopp@som.umaryland.edu) |
| University of Michigan University Hospital Ann Arbor, Michigan | Mariama Runcie, MD - (runciema@med.umich.edu) |
| University of Minnesota Masonic Children's Hospital Minneapolis, Minnesota | James Miner, MD - (miner015@umn.edu) |
| University of Minnesota Medical Center Minneapolis, Minnesota | James Miner, MD - (miner015@umn.edu) |
| University of Utah Healthcare Salt Lake City, Utah | Scott Youngquist, MD - (scott.youngquist@utah.edu) |
| University of Virginia Medical Center Charlottesville, Virginia | Thomas Hartka, MD - (trh6u@uvahealth.org) |
| VCU Medical Center Richmond, Virginia | Lisa Merck, MD, MPH, MHA - (Lisa.Merck@vcuhealth.org) |
| Yale New Haven Hospital New Haven, Connecticut | Charles Wira, MD - (charles.wira@yale.edu) |