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621 Study Matches
A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies (CaDAnCe-101)
BeOne Medicines - clinicaltrials@beonemed.com
NCT05006716
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Inclusion Criteria :
• Confirmed diagnosis (per World Health Organization (WHO) guidelines, unless otherwise noted) of one of the following: Marginal Zone Lymphoma (MZL), R/R follicular lymphoma (FL), mantle cell lymphoma (MCL), chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL), Waldenström macroglobulinemia (WM), R/R diffuse large B-cell lymphoma (DLBCL), or Richter's transformation to DLBCL.
• Participants who have previously received a covalently-binding Bruton´s tyrosine kinase (BTK) inhibitor (BTKi) in any line of therapy must have received treatment with the BTK inhibitor for ≥ 8 weeks (unless reason for discontinuation is intolerance).
• For dose-finding and dose-expansion, participants who had previously received a covalently-binding BTK inhibitor as monotherapy or in combination with other anticancer agents are eligible for the study if they meet any of the following criteria: discontinued the previous BTK inhibitor due to disease progression, experienced disease progression after completing treatment with a BTK inhibitor or discontinued the BTK inhibitor due to toxicity or intolerance.
• Phase 2 Cohorts in R/R CLL/SLL, R/R MCL, and R/R WM only: Participants who previously received a BTKi are eligible if they had disease progression on only one regimen containing a covalent BTKi. Note: Participants may have received treatment with ≥ 2 different covalent BTKis if additional BTKis were discontinued secondary to an event other than disease progression.
• Measurable disease by radiographic assessment or serum IgM level (WM only)
• Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 2
• Participants enrolling in the dose finding phase of the study may be previously treated with a BTKi or may be naïve to BTKi therapy depending on the diagnosis and country of enrollment; participants with MCL enrolling in the expansion cohorts (Phase 2) must have been treated with a BTKi in a prior line of therapy; CLL/SLL participants, in addition to being treated with a BTKi in a prior line of therapy, must also have received a Bcl-2 inhibitor in a prior line of therapy as well (Phase 2).
• Prior malignancy (other than the disease under study) within the past 2 years, except in situ malignancies that have been curatively resected, localized breast cancer treated with curative intent with no evidence of breast active disease for more than 3 years and receiving adjuvant hormonal therapy, localized Gleason score ≤ 6 prostate cancer undergoing observation or treatment with androgen depravation, or any other cancer treated with curative intent, not on adjuvant treatment, and in the opinion of the investigator is unlikely to recur.
• Requires ongoing systemic treatment for any other malignancy
• Requires ongoing systemic (defined as ≥ 10 mg/day of prednisone or equivalent) corticosteroid treatment.
• Current or history of central nervous system involvement including the brain, spinal cord, leptomeninges, and cerebrospinal fluid (as documented by imaging, cytology, or biopsy) by B-cell malignancy, regardless of whether participants had received treatment for central nervous system disease
• Known active plasma cell neoplasm, prolymphocytic leukemia, T-cell lymphoma, Burkitt lymphoma, acquired immunodeficiency syndrome (AIDS)-related B-cell lymphoma, Castleman disease, post-transplant lymphoproliferative disorders, hairy cell leukemia, germinal center B-cell (GCB), DLBCL, EBV+ DLBCL NOS, primary DLBCL of the central nervous system (CNS), primary cutaneous DLBCL - leg type, DLBCL associated with chronic inflammation, primary mediastinal (thymic) large B-cell lymphoma, intravascular large B-cell lymphoma, ALK+ large B-cell lymphoma, primary effusion lymphoma, high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, high-grade B-cell lymphoma - NOS, B-cell lymphoma unclassifiable with features intermediate between DLBCL and classical Hodgkin lymphoma, or history of or currently suspected transformation of an indolent lymphoma to an aggressive histology (except for participants with Richter Transformation to DLBCL are eligible for Part 1a, 1c, or Phase 2 and participants with history of follicular lymphoma transforming to non-GCB DLBCL who are eligible for Part 1a, 1c, or Phase 2). Note: Other protocol defined Inclusion/Exclusion criteria may apply.
• Confirmed diagnosis (per World Health Organization (WHO) guidelines, unless otherwise noted) of one of the following: Marginal Zone Lymphoma (MZL), R/R follicular lymphoma (FL), mantle cell lymphoma (MCL), chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL), Waldenström macroglobulinemia (WM), R/R diffuse large B-cell lymphoma (DLBCL), or Richter's transformation to DLBCL.
• Participants who have previously received a covalently-binding Bruton´s tyrosine kinase (BTK) inhibitor (BTKi) in any line of therapy must have received treatment with the BTK inhibitor for ≥ 8 weeks (unless reason for discontinuation is intolerance).
• For dose-finding and dose-expansion, participants who had previously received a covalently-binding BTK inhibitor as monotherapy or in combination with other anticancer agents are eligible for the study if they meet any of the following criteria: discontinued the previous BTK inhibitor due to disease progression, experienced disease progression after completing treatment with a BTK inhibitor or discontinued the BTK inhibitor due to toxicity or intolerance.
• Phase 2 Cohorts in R/R CLL/SLL, R/R MCL, and R/R WM only: Participants who previously received a BTKi are eligible if they had disease progression on only one regimen containing a covalent BTKi. Note: Participants may have received treatment with ≥ 2 different covalent BTKis if additional BTKis were discontinued secondary to an event other than disease progression.
• Measurable disease by radiographic assessment or serum IgM level (WM only)
• Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 2
• Participants enrolling in the dose finding phase of the study may be previously treated with a BTKi or may be naïve to BTKi therapy depending on the diagnosis and country of enrollment; participants with MCL enrolling in the expansion cohorts (Phase 2) must have been treated with a BTKi in a prior line of therapy; CLL/SLL participants, in addition to being treated with a BTKi in a prior line of therapy, must also have received a Bcl-2 inhibitor in a prior line of therapy as well (Phase 2).
Exclusion Criteria:
• Prior malignancy (other than the disease under study) within the past 2 years, except in situ malignancies that have been curatively resected, localized breast cancer treated with curative intent with no evidence of breast active disease for more than 3 years and receiving adjuvant hormonal therapy, localized Gleason score ≤ 6 prostate cancer undergoing observation or treatment with androgen depravation, or any other cancer treated with curative intent, not on adjuvant treatment, and in the opinion of the investigator is unlikely to recur.
• Requires ongoing systemic treatment for any other malignancy
• Requires ongoing systemic (defined as ≥ 10 mg/day of prednisone or equivalent) corticosteroid treatment.
• Current or history of central nervous system involvement including the brain, spinal cord, leptomeninges, and cerebrospinal fluid (as documented by imaging, cytology, or biopsy) by B-cell malignancy, regardless of whether participants had received treatment for central nervous system disease
• Known active plasma cell neoplasm, prolymphocytic leukemia, T-cell lymphoma, Burkitt lymphoma, acquired immunodeficiency syndrome (AIDS)-related B-cell lymphoma, Castleman disease, post-transplant lymphoproliferative disorders, hairy cell leukemia, germinal center B-cell (GCB), DLBCL, EBV+ DLBCL NOS, primary DLBCL of the central nervous system (CNS), primary cutaneous DLBCL - leg type, DLBCL associated with chronic inflammation, primary mediastinal (thymic) large B-cell lymphoma, intravascular large B-cell lymphoma, ALK+ large B-cell lymphoma, primary effusion lymphoma, high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, high-grade B-cell lymphoma - NOS, B-cell lymphoma unclassifiable with features intermediate between DLBCL and classical Hodgkin lymphoma, or history of or currently suspected transformation of an indolent lymphoma to an aggressive histology (except for participants with Richter Transformation to DLBCL are eligible for Part 1a, 1c, or Phase 2 and participants with history of follicular lymphoma transforming to non-GCB DLBCL who are eligible for Part 1a, 1c, or Phase 2). Note: Other protocol defined Inclusion/Exclusion criteria may apply.
DRUG: BGB-16673
B-cell Malignancy, Marginal Zone Lymphoma, Follicular Lymphoma, Non-Hodgkin Lymphoma, Waldenstrom Macroglobulinemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Diffuse Large B Cell Lymphoma
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Study Locations
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| Location | Contacts |
|---|---|
| Aichi Cancer Center Hospital Clinical Oncology Nagoya, Aichi-ken | |
| American Oncology Partners of Maryland Pa Bethesda, Maryland | |
| Arensia Exploratory Medicine Llc Tbilisi, | |
| Arthur Je Child Comprehensive Cancer Centre Calgary, Alberta | |
| Asan Medical Center Seoul, | |
| Augusta University Augusta, Georgia | |
| Austin Health Heidelberg, Victoria | |
| British Columbia Cancer Agency the Vancouver Centre Vancouver, British Columbia | |
| CHU Henri Mondor Créteil, | |
| Calvary Mater Newcastle Waratah, New South Wales | |
| Cancer Institute Hospital of Jfcr Kotoku, Tokyo | |
| Centre Henri Becquerel Rouen, | |
| Centre Leon Berard Lyon Cedex08, | |
| Centre de Lutte Contre Le Cancer Institut Bergonie Bordeaux, | |
| Centro Gaucho Integrado de Oncologia Hospital Mae de Deus Porto Alegre, | |
| Centroricerche Cliniche Di Verona Srl Verona, | |
| Chiba Cancer Center Chiba, Chiba | |
| Chu Montpellier Hopital Saint Eloi Montpellier, | |
| Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic) Québec, | |
| Columbia University Medical Center New York, New York | |
| Comprehensive Cancer Centers of Nevada Las Vegas, Nevada | |
| Concord Repatriation General Hospital Concord, New South Wales | |
| Cross Cancer Institute Edmonton, Alberta | |
| Dana Farber Cancer Institute Boston, Massachusetts | |
| Derriford Hospital Plymouth, | |
| Dokuz Eylul University Balçova, | |
| Edinburgh Cancer Centre Edinburgh, | |
| Erciyes University Kayseri, | |
| Fondazione Policlinico Universitario Agostino Gemelli Roma, | |
| Fred Hutchinson Cancer Research Center Seattle, Washington | |
| Freeman Hospital Newcastle upon Tyne, | |
| Fujian Medical University Union Hospital Fuzhou, Fujian | |
| Genesiscare Cambridge Newmarket, | |
| Guangxi Medical University Cancer Hospital Wuxiang Branch Nanning, Guangxi | |
| Henan Cancer Hospital Zhengzhou, Henan | |
| Honor Health Research Institute Scottsdale, Arizona | |
| Hopital Claude Huriez Chu Lille Lille, | |
| Hopital Estaing ClermontFerrand, | |
| Hopital de la Pitie Salpetriere Paris, | |
| Hospital Alemão Oswaldo Cruz São Paulo, | |
| Hospital Clinico Universitario de Valencia Valencia, | |
| Hospital Erasto Gaertner Curitiba, | |
| Hospital Ernesto Dornelles Porto Alegre, | |
| Hospital General Universitario Gregorio Marañon Madrid, | |
| Hospital Nove de Julho Dasa São Paulo, | |
| Hospital Sirio Libanes Brasilia Brasília, | |
| Hospital Universitario Fundacion Jimenez Diaz Madrid, | |
| Hospital Universitario La Paz Madrid, | |
| Hospital Universitario Puerta de Hierro Majadahonda Majadahonda, | |
| Hospital Universitario Vall Dhebron Barcelona, | |
| Inje University Busan Paik Hospital BusanjinGu, Busan Gwang'yeogsi | |
| Institut Paoli Calmettes Marseille, | |
| Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciencestuanbo Branch Tianjin, Tianjin Municipality | |
| Instituto Dor de Pesquisa E Ensino Sao Paulo São Paulo, | |
| Instituto de Pesquisa Em Saude Da Universidade de Caxias Do Sul Caxias do Sul, | |
| Istituto Europeo Di Oncologia Milan, | |
| Jiangsu Province Hospital Nanjing, Jiangsu | |
| Karmanos Cancer Institute Detroit, Michigan | |
| Karolinska Universitetssjukhuset Solna Stockholm, | |
| Klinikum Grosshadern Ludwig Maximilians Universitat Munchen München, | |
| Klinikum Johannes Gutenberg Universitaet Mainz Mainz, | |
| Linear Clinical Research Nedlands, Western Australia | |
| MD Anderson Cancer Center Houston, Texas | |
| Mary Bird Perkins Cancer Center Baton Rouge, Louisiana | |
| Mayo Clinic Jacksonville Jacksonville, Florida | |
| Mayo Clinic Phoenix Phoenix, Arizona | |
| Mayo Clinic Rochester Rochester, Minnesota | |
| Md Anderson Cancer Center Madrid Spain Madrid, | |
| Memorial Sloan Kettering Cancer Center MSKCC New York, New York | |
| Midwestern Regional Medical Center Zion, Illinois | |
| Mount Sinai Medical Center Braman Comprehensive Cancer Center Miami, Florida | |
| Nanfang Hospital, Southern Medical University Guangzhou, Guangdong | |
| National Cancer Center Hospital East Kashiwa, | |
| Niguarda Cancer Center Division of Hematology Milan, | |
| Norton Cancer Institute Pavilion Louisville, Kentucky | |
| Nottingham University Hospitals NHS Trust Nottingham, | |
| Ondokuz Mayis University Samsun, | |
| Ospedale San Raffaele Milan, | |
| Peking Union Medical College Hospital Beijing, Beijing Municipality | |
| Perth Blood Institute West Perth, Western Australia | |
| Peter MacCallum Cancer Centre Melbourne, Victoria | |
| Policlinico Sorsola Malpighi, Aou Di Bologna Bologna, | |
| Princess Alexandra Hospital Woolloongabba, Queensland | |
| Princess Margaret Cancer Centre Toronto, Ontario | |
| Pusan National University Hospital Seogu, Busan Gwang'yeogsi | |
| Real E Benemerita Associacao Portuguesa de Sao Paulo São Paulo, | |
| Roswell Park Comprehensive Cancer Center Buffalo, New York | |
| Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai, Shanghai Municipality | |
| Sahlgrenska University Hospital Hematology Gothenburg, | |
| Sakarya Training and Research Hospital Sakarya, | |
| Samsung Medical Center Seoul, | |
| Seoul National University Hospital Seoul, Seoul Teugbyeolsi | |
| Severance Hospital Yonsei University Health System SeodaemunGu, Seoul Teugbyeolsi | |
| Shengjing Hospital of China Medical Universityshenbei Branch Shenyang, Liaoning | |
| Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein São Paulo, | |
| Southeastern Regional Medical Center Newnan, Georgia | |
| St Jamess University Hospital Leeds, | |
| St Vincents Hospital Melbourne Fitzroy, Victoria | |
| Stanford Medicine Palo Alto, California | |
| Tampa General Hospital Cancer Institute Tampa, Florida | |
| Tennesse Oncology Chattanooga Downtown Chattanooga, Tennessee | |
| Tennessee Oncology, Pllc Nashville Nashville, Tennessee | |
| The Alfred Hospital Melbourne, Victoria | |
| The Catholic University of Korea, Seoul St Marys Hospital SeochoGu, Seoul Teugbyeolsi | |
| The First Affiliated Hospital of Chongqing Medical University Chongqing, Chongqing Municipality | |
| The First Affiliated Hospital of Nanchang University Branch Xianghu Nanchang, Jiangxi | |
| The First Affiliated Hospital of Soochow University Suzhou, Jiangsu | |
| The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang | |
| The First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan | |
| The First Affiliated Hospital, Zhejiang University School of Medicinechengzhan Hangzhou, Zhejiang | |
| The Fourth Hospital of Hebei Medical University East Branch Shijiazhuang, Hebei | |
| The Institute of Oncology, Arensia Exploratory Medicine Chisinau, | |
| Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin Municipality | |
| Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan, Hubei | |
| UCLA Santa Monica Cancer Care Santa Monica, California | |
| Uchealth North Fort Collins, Colorado | |
| Uniklinik Koeln (Aoer) Cologne, | |
| Union Hospital of Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei | |
| Universitaetsklinikum Schleswig Holstein Campus Luebeck Lübeck, | |
| Universitaetsklinikum Ulm Ulm, | |
| Universitares Krebszentrum Leipzig Leipzig, | |
| Universitatsklinikum Carl Gustav Carus An Der Technischen Universitat Dresden Dresden, | |
| University of Alabama at Birmingham Hospital Birmingham, Alabama | |
| University of Arizona Cancer Center Tucson, Arizona | |
| University of California San Diego (Ucsd) Moores Cancer Center La Jolla, California | |
| University of Iowa Hospitals and Clinics Iowa City, Iowa | |
| Virginia Commonwealth University Massey Cancer Center Richmond, Virginia | |
| Weill Cornell Medical College Newyork Presbyterian Hospital New York, New York | |
| Yichang Central Peoples Hospitaljiangnan Branch Yichang, Hubei | |
| Yokohama Municipal Citizens Hospital Yokohama, |
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics (COSMIC)
Karen Craver - NCORP@wfusm.edu
NCT06418204
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Inclusion Criteria:
* Adults aged 18 years or older with one of the following newly diagnosed cancers: breast cancer, colorectal cancer, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer (e.g. adenocarcinoma, squamous cell carcinoma, large cell carcinoma, adenosquamous cell carcinoma, and not otherwise specified).
* Planned treatment with systemic chemotherapy (single or multi-agent, includes targeted therapy) and/or immune checkpoint inhibitor therapy (targeting PD-1, PD-L1 or CTLA-4). If unable to engage participant before treatment starts, enrollment is allowed up to the start of Cycle 2 treatment.
* Participants must be able to comprehend English or Spanish (for survey completion).
* Participants must have a working email address and be must be willing to complete surveys online. This can be completed at home, in the clinic or other location.
* Completion of the confidential Self-Reported Screening Survey and receipt of a screening result - eligible for enrollment.
* Participant must reside in the United States, officially determined per patient report on Self-reported Screening Survey
* In the treating provider's opinion, the participant should have a life expectancy of \>=6 months. Participants in hospice are not eligible.
Optional Sub-study (available at select sites only):
* Must be willing to participate in both the main study and the sub-study at the Wake Forest University Comprehensive Cancer Center (WF CCC) and Virginia Commonwealth University (VCU).
* Must be receiving treatment at the WF CCC and VCU.
* Must be diagnosed with non-small cell lung cancer.
* Must be planning to receive paclitaxel as part of their chemotherapy in conjunction with Immune Checkpoint Inhibitor (ICIs) PD-1, PD-L1 or CTLA-4.
Exclusion Criteria:
* Currently enrolled in an interventional supportive treatment trial to manage cancer symptoms.
* Participants with known pregnancy.
* Participant received systemic therapy treatment for prior cancer(s) including chemotherapy, immunotherapy, targeted therapy, and hormonal therapy.
* Participants enrolled in hospice.
Optional Substudy (available at select sites only):
* Participants with chronic or ongoing steroid or immunomodulatory agents (i.e., prednisone, dexamethasone, etanercept, infliximab, etc.). The use of glucocorticoids as pre-medications for chemotherapy treatment is allowed.
* Participants with a history of HIV, hepatitis B or hepatitis C. OTHER: Non-interventional Study
Breast Carcinoma, Colorectal Carcinoma, Lung Non-Small Cell Carcinoma, Melanoma, Non-Hodgkin Lymphoma
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Show 467 locations
Study Locations
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| Location | Contacts |
|---|---|
| AMG Crystal Lake - Oncology Crystal Lake, Illinois | - (advocateresearch@advocate.com) |
| AMG Libertyville - Oncology Libertyville, Illinois | - (advocateresearch@advocatehealth.com) |
| Abbott-Northwestern Hospital Minneapolis, Minnesota | - (mmcorc@healthpartners.com) |
| Adams Cancer Center Gettysburg, Pennsylvania | |
| Advocate Christ Medical Center Oak Lawn, Illinois | |
| Advocate Good Samaritan Hospital Downers Grove, Illinois | - (Barbara.barhamand@advocatehealth.com) |
| Advocate Good Shepherd Hospital Barrington, Illinois | |
| Advocate High Tech Medical Park Palos Heights, Illinois | - (ncorp@aah.org) |
| Advocate Illinois Masonic Medical Center Chicago, Illinois | |
| Advocate Lutheran General Hospital Park Ridge, Illinois | |
| Advocate Outpatient Center - Aurora Aurora, Illinois | - (ncorp@aah.org) |
| Advocate Outpatient Center - Oak Lawn Oak Lawn, Illinois | - (ncorp@aah.org) |
| Advocate Sherman Hospital Elgin, Illinois | |
| Advocate South Suburban Hospital Hazel Crest, Illinois | |
| AnMed Health Cancer Center Anderson, South Carolina | - (rhonda.ballew@anmedhealth.org) |
| Annie Penn Memorial Hospital Reidsville, North Carolina | - (stacey.phelps@conehealth.com) |
| Armes Family Cancer Center Findlay, Ohio | - (clinical.trials@daytonncorp.org) |
| Ascension All Saints Hospital Racine, Wisconsin | - (AWRI.Inquiry@Ascension.org) |
| Ascension Calumet Hospital Chilton, Wisconsin | - (AWRI.inquiry@ascension.org) |
| Ascension Columbia Saint Mary's Hospital - Milwaukee Milwaukee, Wisconsin | - (AWRI.Inquiry@Ascension.org) |
| Ascension Columbia Saint Mary's Hospital Ozaukee Mequon, Wisconsin | - (AWRI.Inquiry@Ascension.org) |
| Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa, Wisconsin | - (AWRI.Inquiry@Ascension.org) |
| Ascension Mercy Hospital Oshkosh, Wisconsin | - (AWRI.inquiry@ascension.org) |
| Ascension Saint Elizabeth Hospital Appleton, Wisconsin | - (AWRI.inquiry@ascension.org) |
| Ascension Saint Francis - Reiman Cancer Center Franklin, Wisconsin | - (AWRI.Inquiry@Ascension.org) |
| Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield, Wisconsin | - (AWRI.Inquiry@Ascension.org) |
| Aspirus Cancer Care - James Beck Cancer Center Rhinelander, Wisconsin | - (Beth.Knetter@aspirus.org) |
| Aspirus Cancer Care - Stevens Point Stevens Point, Wisconsin | - (Beth.Knetter@aspirus.org) |
| Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids, Wisconsin | |
| Aspirus Langlade Hospital Antigo, Wisconsin | - (Juli.Alford@aspirus.org) |
| Aspirus Medford Hospital Medford, Wisconsin | - (Beth.Knetter@aspirus.org) |
| Aspirus Regional Cancer Center Wausau, Wisconsin | |
| Atrium Health Cabarrus/LCI-Concord Concord, North Carolina | |
| Atrium Health Cleveland/LCI-Cleveland Shelby, North Carolina | |
| Atrium Health Navicent Macon, Georgia | - (andrew.weatherall@atriumhealth.org) |
| Atrium Health Pineville/LCI-Pineville Charlotte, North Carolina | |
| Atrium Health Stanly/LCI-Albemarle Albemarle, North Carolina | |
| Atrium Health Union/LCI-Union Monroe, North Carolina | |
| Atrium Health University City/LCI-University Charlotte, North Carolina | |
| Augusta Health Center for Cancer and Blood Disorders Fishersville, Virginia | |
| Aurora Bay Area Medical Group-Marinette Marinette, Wisconsin | - (ncorp@aurora.org) |
| Aurora BayCare Medical Center Green Bay, Wisconsin | - (ncorp@aurora.org) |
| Aurora Cancer Care-Grafton Grafton, Wisconsin | - (ncorp@aurora.org) |
| Aurora Cancer Care-Kenosha South Kenosha, Wisconsin | - (ncorp@aurora.org) |
| Aurora Cancer Care-Milwaukee Milwaukee, Wisconsin | - (ncorp@aurora.org) |
| Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin | - (ncorp@aurora.org) |
| Aurora Cancer Care-Racine Racine, Wisconsin | - (ncorp@aurora.org) |
| Aurora Cancer Care-Southern Lakes VLCC Burlington, Wisconsin | - (ncorp@aurora.org) |
| Aurora Health Care Germantown Health Center Germantown, Wisconsin | - (ncorp@aurora.org) |
| Aurora Medical Center in Summit Summit, Wisconsin | - (ncorp@aurora.org) |
| Aurora Saint Luke's Medical Center Milwaukee, Wisconsin | - (ncorp@aurora.org) |
| Aurora Saint Luke's South Shore Cudahy, Wisconsin | - (ncorp@aurora.org) |
| Aurora Sinai Medical Center Milwaukee, Wisconsin | - (ncorp@aurora.org) |
| Aurora West Allis Medical Center West Allis, Wisconsin | - (ncorp@aurora.org) |
| BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri | |
| Baptist Cancer Center-Grenada Grenada, Mississippi | - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee | - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Desoto Southhaven, Mississippi | - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus, Mississippi | - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee | - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Oxford Oxford, Mississippi | - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Union County New Albany, Mississippi | - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital for Women Memphis, Tennessee | - (BCCclintrials@bmhcc.org) |
| Beaufort Memorial Hospital Beaufort, South Carolina | - (kwade@bmhsc.org) |
| Beebe Health Campus Rehoboth Beach, Delaware | - (research@beebehealthcare.org) |
| Beebe South Coastal Health Campus Millville, Delaware | - (research@beebehealthcare.org) |
| Benefis Sletten Cancer Institute Great Falls, Montana | - (mccinfo@mtcancer.org) |
| Billings Clinic Cancer Center Billings, Montana | - (research@billingsclinic.org) |
| Blanchard Valley Hospital Findlay, Ohio | - (clinical.trials@daytonncorp.org) |
| Bozeman Health Deaconess Hospital Bozeman, Montana | - (mccinfo@mtcancer.org) |
| Broadlawns Medical Center Des Moines, Iowa | |
| Bronson Battle Creek Battle Creek, Michigan | - (crcwm-regulatory@crcwm.org) |
| CHI Health Good Samaritan Kearney, Nebraska | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Cancer Care Center of O'Fallon O'Fallon, Illinois | - (morganthaler.jodi@mhsil.com) |
| Cancer Care Specialists of Illinois - Decatur Decatur, Illinois | - (morganthaler.jodi@mhsil.com) |
| Cancer Center at Saint Joseph's Phoenix, Arizona | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Cancer Hematology Centers - Flint Flint, Michigan | - (wstrong@ghci.org) |
| Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan | |
| Carilion Roanoke Memorial Hospital Roanoke, Virginia | |
| Carle Cancer Center Urbana, Illinois | - (Research@carle.com) |
| Carle Cancer Institute Normal Normal, Illinois | - (Research@Carle.com) |
| Carle Physician Group-Effingham Effingham, Illinois | - (Research@carle.com) |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | - (Research@carle.com) |
| Carle at The Riverfront Danville, Illinois | - (Research@Carle.com) |
| CaroMont Health - Lincoln Cancer Center Lincolnton, North Carolina | |
| CaroMont Regional Medical Center Gastonia, North Carolina | - (tammy.cozad@caromonthealth.org) |
| Carolinas Medical Center/Levine Cancer Institute Charlotte, North Carolina | |
| Centra Alan B Pearson Regional Cancer Center Lynchburg, Virginia | - (Kevin.Patel@centrahealth.com) |
| CentraState Medical Center Freehold, New Jersey | |
| Central Vermont Medical Center Berlin Corners, Vermont | |
| Centralia Oncology Clinic Centralia, Illinois | - (morganthaler.jodi@mhsil.com) |
| Centro Comprensivo de Cancer de UPR San Juan, | - (dcuadrado@cccupr.org) |
| Chilton Medical Center Pompton, New Jersey | |
| Christiana Care - Union Hospital Elkton, Maryland | - (frank.crum@christianacare.org) |
| Coborn Cancer Center at Saint Cloud Hospital Saint Cloud, Minnesota | - (coborncancercenter@centracare.com) |
| Colorado Blood Cancer Institute Denver, Colorado | - (info@westernstatesncorp.org) |
| Community Hospital of Anaconda Anaconda, Montana | - (mccinfo@mtcancer.org) |
| Community Medical Center Missoula, Montana | - (mccinfo@mtcancer.org) |
| Community Medical Center Missoula, Montana | - (HemonCCTrials@geisinger.edu) |
| Condell Memorial Hospital Libertyville, Illinois | - (advocateresearch@advocatehealth.com) |
| Cone Health Cancer Center Greensboro, North Carolina | - (stacey.phelps@conehealth.com) |
| Cone Health Cancer Center at Alamance Regional Burlington, North Carolina | - (stacey.phelps@conehealth.com) |
| Cone Health Cancer Center at Drawbridge Parkway Greensboro, North Carolina | - (stacey.phelps@conehealth.com) |
| Cone Health MedCenter Asheboro Asheboro, North Carolina | - (stacey.phelps@conehealth.com) |
| Contra Costa Regional Medical Center Martinez, California | |
| Contra Costa Regional Medical Center Martinez, California | |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan | - (crcwm-regulatory@crcwm.org) |
| Corewell Health Reed City Hospital Reed City, Michigan | - (crcwm-regulatory@crcwm.org) |
| Cotton O'Neil Cancer Center / Stormont Vail Health Topeka, Kansas | |
| Cox Health South Hospital Springfield, Missouri | |
| CoxHealth South Hospital Springfield, Missouri | |
| Crossroads Cancer Center Effingham, Illinois | - (morganthaler.jodi@mhsil.com) |
| Dayton Physician LLC - Englewood Dayton, Ohio | - (clinical.trials@daytonncorp.org) |
| Dayton Physicians LLC-Atrium Franklin, Ohio | - (clinical.trials@daytonncorp.org) |
| Decatur Memorial Hospital Decatur, Illinois | - (morganthaler.jodi@mhsil.com) |
| Doctors Cancer Center Manati, | |
| Duluth Clinic Ashland Ashland, Wisconsin | - (CancerTrials@EssentiaHealth.org) |
| Edwards Comprehensive Cancer Center Huntington, West Virginia | - (Christina.Cole@chhi.org) |
| Englewood Hospital and Medical Center Englewood, New Jersey | |
| Ephrata Cancer Center Ephrata, Pennsylvania | |
| Essentia Health - Deer River Clinic Deer River, Minnesota | - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Fosston Fosston, Minnesota | - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Park Rapids Park Rapids, Minnesota | - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center Duluth, Minnesota | - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center-South University Clinic Fargo, North Dakota | - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Hibbing Clinic Hibbing, Minnesota | |
| Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota | - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes, Minnesota | - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Sandstone Sandstone, Minnesota | - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Virginia Clinic Virginia, Minnesota | - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Hayward Clinic Hayward, Wisconsin | - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Spooner Clinic Spooner, Wisconsin | - (CancerTrials@EssentiaHealth.org) |
| Fairbanks Memorial Hospital Fairbanks, Alaska | - (Veronica.Stevenson@foundationhealth.org) |
| Fairview Northland Medical Center Princeton, Minnesota | - (mmcorc@healthpartners.com) |
| Fairview Southdale Hospital Edina, Minnesota | - (mmcorc@healthpartners.com) |
| Flaget Memorial Hospital Bardstown, Kentucky | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Geisinger Cancer Center Dickson City Dickson City, Pennsylvania | - (hemoncctrials@geisinger.edu) |
| Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania | - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center Danville, Pennsylvania | - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania | - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania | - (HemonCCTrials@geisinger.edu) |
| Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania | - (HemonCCTrials@geisinger.edu) |
| Genesee Hematology Oncology PC Flint, Michigan | - (wstrong@ghci.org) |
| Gibbs Cancer Center-Gaffney Gaffney, South Carolina | - (kmertz-rivera@gibbscc.org) |
| Gibbs Cancer Center-Pelham Greer, South Carolina | - (kmertz-rivera@gibbscc.org) |
| Glens Falls Hospital Glens Falls, New York | Misty J DeCaro - (lacrosmj@glensfallshosp.org) |
| Greater Dayton Cancer Center Kettering, Ohio | - (clinical.trials@daytonncorp.org) |
| Gundersen Lutheran Medical Center La Crosse, Wisconsin | - (cancerctr@gundersenhealth.org) |
| HSHS Saint Elizabeth's Hospital O'Fallon, Illinois | - (morganthaler.jodi@mhsil.com) |
| Hackettstown Medical Center Hackettstown, New Jersey | |
| Harold Alfond Center for Cancer Care Augusta, Maine | |
| Hawaii Cancer Care - Westridge ‘Aiea, Hawaii | - (info@hawaiicancercare.com) |
| Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii | - (i.webster@hawaiicancercare.com) |
| HaysMed Hays, Kansas | |
| Hayworth Cancer Center High Point, North Carolina | |
| Heartland Regional Medical Center Saint Joseph, Missouri | - (Trisha.England2@mymlc.com) |
| Helen F Graham Cancer Center Newark, Delaware | - (lbarone@christianacare.org) |
| Hematology Oncology Associates of Fredericksburg Inc Fredericksburg, Virginia | - (cvaughn@hoafredericksburg.com) |
| Hennepin County Medical Center Minneapolis, Minnesota | - (mmcorc@healthpartners.com) |
| Hi-Line Sletten Cancer Center Havre, Montana | - (mccinfo@mtcancer.org) |
| Holy Name Hospital Teaneck, New Jersey | |
| Illinois CancerCare - Washington Washington, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Bloomington Bloomington, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Canton Canton, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Carthage Carthage, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Dixon Dixon, Illinois | |
| Illinois CancerCare-Eureka Eureka, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Galesburg Galesburg, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Kewanee Clinic Kewanee, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Macomb Macomb, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Ottawa Clinic Ottawa, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Pekin Pekin, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peoria Peoria, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peru Peru, Illinois | - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Princeton Princeton, Illinois | - (andersonj@illinoiscancercare.com) |
| Indu and Raj Soin Medical Center Beavercreek, Ohio | - (clinical.trials@daytonncorp.org) |
| Iowa Methodist Medical Center Des Moines, Iowa | |
| Jefferson Healthcare Port Townsend, Washington | |
| John H Stroger Jr Hospital of Cook County Chicago, Illinois | |
| Kadlec Clinic Hematology and Oncology Kennewick, Washington | - (research@kadlecmed.org) |
| Kaiser Permanente Bellevue Medical Center Bellevue, Washington | - (KPWAoncologytrials@kp.org) |
| Kaiser Permanente Downtown Commons Sacramento, California | - (kpoct@kp.org) |
| Kaiser Permanente Dublin Dublin, California | |
| Kaiser Permanente Fresno Orchard Plaza Fresno, California | |
| Kaiser Permanente Medical Center - Santa Clara Santa Clara, California | - (Kpoct@kp.org) |
| Kaiser Permanente Medical Center-Vacaville Vacaville, California | - (Kpoct@kp.org) |
| Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii | - (shelley.a.clark@kp.org) |
| Kaiser Permanente Northwest Portland, Oregon | - (information@kpchr.org) |
| Kaiser Permanente San Leandro San Leandro, California | - (Kpoct@kp.org) |
| Kaiser Permanente Washington Seattle, Washington | - (KPWAoncologytrials@kp.org) |
| Kaiser Permanente- Marshall Medical Offices Redwood City, California | |
| Kaiser Permanente- Modesto MOB II Modesto, California | |
| Kaiser Permanente-Deer Valley Medical Center Antioch, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Franklin Denver, Colorado | - (kristi.m.bronkan@kp.org) |
| Kaiser Permanente-Fremont Fremont, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Fresno Fresno, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Lone Tree Lone Tree, Colorado | - (kristi.m.bronkan@kp.org) |
| Kaiser Permanente-Modesto Modesto, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Oakland Oakland, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Richmond Richmond, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Rock Creek Lafayette, Colorado | - (kristi.m.bronkan@kp.org) |
| Kaiser Permanente-Roseville Roseville, California | - (Kpoct@kp.org) |
| Kaiser Permanente-San Francisco San Francisco, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Santa Rosa Santa Rosa, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Santa Teresa-San Jose San Jose, California | - (Kpoct@kp.org) |
| Kaiser Permanente-South Sacramento Sacramento, California | - (Kpoct@kp.org) |
| Kaiser Permanente-South San Francisco South San Francisco, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Stockton Stockton, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Vallejo Vallejo, California | - (Kpoct@kp.org) |
| Kaiser Permanente-Walnut Creek Walnut Creek, California | - (Kpoct@kp.org) |
| Kaiser San Rafael-Gallinas San Rafael, California | - (Kpoct@kp.org) |
| Kapiolani Medical Center for Women and Children Honolulu, Hawaii | |
| Kettering Medical Center Kettering, Ohio | - (clinical.trials@daytonncorp.org) |
| Kettering Medical Center Kettering, Ohio | - (clinical.trials@daytonncorp.org) |
| Kingman Regional Medical Center Kingman, Arizona | - (research@sncrf.org) |
| Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho | - (mccinfo@mtcancer.org) |
| Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho | - (mccinfo@mtcancer.org) |
| Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho | - (mccinfo@mtcancer.org) |
| LSU Health Sciences Center at Shreveport Shreveport, Louisiana | - (LPost@lsuhsc.edu) |
| Lake Regional Hospital Osage Beach, Missouri | - (clinicaltrials@lakeregional.com) |
| Lakeview Hospital Stillwater, Minnesota | - (mmcorc@healthpartners.com) |
| Lawrence Memorial Hospital Lawrence, Kansas | - (Stephanie.Norris@LMH.ORG) |
| Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania | - (Morgan_M.Horton@lvhn.org) |
| Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania | - (Morgan_M.Horton@lvhn.org) |
| Lehigh Valley Hospital-Hazleton Hazleton, Pennsylvania | - (Morgan_M.Horton@lvhn.org) |
| Levine Cancer Institute - Huntersville Huntersville, North Carolina | |
| Levine Cancer Institute - Rutherford Forest City, North Carolina | |
| Levine Cancer Institute - Union West Matthews, North Carolina | |
| Levine Cancer Institute-Ballantyne Charlotte, North Carolina | |
| Levine Cancer Institute-Gaston Gastonia, North Carolina | |
| Levine Cancer Institute-Rock Hill Rock Hill, South Carolina | |
| Levine Cancer Institute-SouthPark Charlotte, North Carolina | |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah, Georgia | - (underberga@sjchs.org) |
| Liberty County Cancer Care Hinesville, Georgia | - (Oncologyresearch@sjchs.org) |
| Licking Memorial Hospital Newark, Ohio | - (Jeffh@columbusccop.org) |
| Logan Health Medical Center Kalispell, Montana | - (mccinfo@mtcancer.org) |
| Lovelace Medical Center-Saint Joseph Square Albuquerque, New Mexico | - (ZPollock@salud.unm.edu) |
| Lovelace Women's Hospital Albuquerque, New Mexico | - (AYost@nmcca.org) |
| MaineHealth Cancer Care Center of York County Sanford, Maine | |
| MaineHealth Cancer Care and IV Therapy - Brunswick Brunswick, Maine | - (clinicalresearch@mainehealth.org) |
| MaineHealth Cancer Care and IV Therapy - Sanford Sanford, Maine | - (clinicalresearch@mainehealth.org) |
| MaineHealth Cancer Care and IV Therapy - South Portland South Portland, Maine | - (clinicalresearch@mainehealth.org) |
| MaineHealth Maine Medical Center - Biddeford Biddeford, Maine | - (clinicalresearch@mainehealth.org) |
| MaineHealth Maine Medical Center- Scarborough Scarborough, Maine | - (clinicalresearch@mainehealth.org) |
| MaineHealth Penobscot Bay Hospital Rockport, Maine | - (clinicalresearch@mainehealth.org) |
| MaineHealth Waldo Hospital Belfast, Maine | - (clinicalresearch@mainehealth.org) |
| Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Clinic-Chippewa Center Chippewa Falls, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Clinic-Wausau Center Wausau, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center - Ladysmith Ladysmith, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center - Minocqua Minocqua, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center - Neillsville Neillsville, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center - Weston Weston, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center Dickinson Iron Mountain, Michigan | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-Marshfield Marshfield, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin | - (oncology.clinical.trials@marshfieldresearch.org) |
| Mayo Clinic Rochester, Minnesota | |
| Mayo Clinic Health System in Albert Lea Albert Lea, Minnesota | |
| Mayo Clinic Health System-Eau Claire Clinic Eau Claire, Wisconsin | |
| Mayo Clinic Health System-Franciscan Healthcare La Crosse, Wisconsin | |
| Mayo Clinic Health Systems-Mankato Mankato, Minnesota | |
| Medical Oncology Hematology Consultants PA Newark, Delaware | - (lbarone@christianacare.org) |
| Medical University of South Carolina Charleston, South Carolina | - (hcc-clinical-trials@musc.edu) |
| Memorial Hospital Chattanooga, Tennessee | - (Jeffh@columbusccop.org) |
| Memorial Medical Center-Las Cruces Las Cruces, New Mexico | - (Deborah.Brown@LPNT.net) |
| Mercy Cancer Center - Carmichael Carmichael, California | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Elk Grove Elk Grove, California | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Rocklin Rocklin, California | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Sacramento Sacramento, California | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center-West Lakes Clive, Iowa | - (cancerresearch@mercydesmoines.org) |
| Mercy Health - Paducah Cancer Center Paducah, Kentucky | - (BJWarner@mercy.com) |
| Mercy Hospital Coon Rapids, Minnesota | - (mmcorc@healthpartners.com) |
| Mercy Hospital Fort Smith Fort Smith, Arkansas | |
| Mercy Hospital Joplin Joplin, Missouri | - (esmeralda.carrillo@mercy.net) |
| Mercy Hospital Oklahoma City Oklahoma City, Oklahoma | |
| Mercy Hospital Saint Louis St Louis, Missouri | |
| Mercy Hospital South St Louis, Missouri | - (Danielle.Werle@mercy.net) |
| Mercy Hospital Springfield Springfield, Missouri | |
| Mercy Medical Center - Des Moines Des Moines, Iowa | - (cancerresearch@mercydesmoines.org) |
| Mercy Oncology and Hematology - Clayton-Clarkson Ballwin, Missouri | |
| Mercy San Juan Medical Center Carmichael, California | - (OncologyResearch@DignityHealth.org) |
| Mid Coast Hospital Brunswick, Maine | - (elizabeth.mutina@mainehealth.org) |
| Minnesota Oncology - Burnsville Burnsville, Minnesota | - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota | - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota | - (mmcorc@healthpartners.com) |
| Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande, California | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mission Hope Medical Oncology - Santa Maria Santa Maria, California | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Missouri Baptist Medical Center St Louis, Missouri | |
| Missouri Baptist Sullivan Hospital Sullivan, Missouri | |
| Missouri Baptist Sullivan Hospital Sullivan, Missouri | |
| Montana Cancer Consortium NCORP Billings, Montana | - (mccinfo@mtcancer.org) |
| Montefiore Medical Center - Moses Campus The Bronx, New York | - (eskwak@montefiore.org) |
| Montefiore Medical Center-Einstein Campus The Bronx, New York | - (eskwak@montefiore.org) |
| Monticello Cancer Center Monticello, Minnesota | - (mmcorc@healthpartners.com) |
| Monument Health Rapid City Hospital Rapid City, South Dakota | - (research@monument.health) |
| Morristown Medical Center Morristown, New Jersey | |
| Morton Plant Hospital Clearwater, Florida | |
| Munson Medical Center Traverse City, Michigan | - (crcwm-regulatory@crcwm.org) |
| MyMichigan Medical Center Alpena Alpena, Michigan | - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Gladwin Gladwin, Michigan | - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Gratiot Alma, Michigan | - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Midland Midland, Michigan | - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Mount Pleasant Mount Pleasant, Michigan | - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Saginaw Saginaw, Michigan | - (MCRCwebsitecontactform@stjoeshealth.org) |
| MyMichigan Medical Center Tawas Tawas City, Michigan | - (MCRCwebsitecontactform@stjoeshealth.org) |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro, Arkansas | |
| New Ulm Medical Center New Ulm, Minnesota | - (mmcorc@healthpartners.com) |
| Newton Medical Center Newton, New Jersey | |
| North Memorial Medical Health Center Robbinsdale, Minnesota | - (mmcorc@healthpartners.com) |
| Northside Hospital Atlanta, Georgia | - (ClinicalTrials@northside.com) |
| Northside Hospital - Duluth Duluth, Georgia | - (Clinical.trials@northside.com) |
| Northside Hospital - Gwinnett Lawrenceville, Georgia | - (Clinical.trials@northside.com) |
| OSF Saint Anthony Medical Center Rockford, Illinois | |
| OSF Saint Anthony's Health Center Alton, Illinois | |
| OSF Saint Francis Hospital and Medical Group Escanaba, Michigan | - (ewd_research_admin@hshs.org) |
| Ochsner LSU Health Monroe Medical Center Monroe, Louisiana | - (LPost@lsuhsc.edu) |
| Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa | |
| OptumCare Cancer Care at Charleston Las Vegas, Nevada | - (research@sncrf.org) |
| OptumCare Cancer Care at Seven Hills Henderson, Nevada | - (research@sncrf.org) |
| Overlook Medical Center Summit, New Jersey | |
| PCR Oncology Arroyo Grande, California | - (research@sncrf.org) |
| PROncology San Juan, | |
| Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo, California | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Pali Momi Medical Center ‘Aiea, Hawaii | |
| Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota | - (mmcorc@healthpartners.com) |
| Parkland Health Center - Farmington Farmington, Missouri | |
| Penrose-Saint Francis Healthcare Colorado Springs, Colorado | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Physicians' Clinic of Iowa PC Cedar Rapids, Iowa | |
| Pocono Medical Center East Stroudsburg, Pennsylvania | - (Morgan_M.Horton@lvhn.org) |
| Presbyterian Kaseman Hospital Albuquerque, New Mexico | - (WBurman@phs.org) |
| Presbyterian Rust Medical Center/Jorgensen Cancer Center Rio Rancho, New Mexico | |
| Prisma Health Cancer Institute - Butternut Greenville, South Carolina | |
| Prisma Health Cancer Institute - Easley Easley, South Carolina | - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Eastside Greenville, South Carolina | |
| Prisma Health Cancer Institute - Faris Greenville, South Carolina | |
| Prisma Health Cancer Institute - Greer Greer, South Carolina | |
| Prisma Health Cancer Institute - Seneca Seneca, South Carolina | |
| Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina | |
| Providence Medical Foundation - Santa Rosa Santa Rosa, California | |
| Providence Saint Mary Regional Cancer Center Walla Walla, Washington | - (Cheryl.Dodd@providence.org) |
| Queen's Cancer Center - Kuakini Honolulu, Hawaii | |
| Queen's Cancer Center - POB I Honolulu, Hawaii | |
| Queen's Medical Center Honolulu, Hawaii | |
| Queens Hospital Center Jamaica, New York | Linda Bulone - (buloneL@nychhc.org) |
| Regional Cancer Care - Jesup Jesup, Georgia | - (Oncologyresearch@sjchs.org) |
| Regions Hospital Saint Paul, Minnesota | - (mmcorc@healthpartners.com) |
| Reid Health Richmond, Indiana | - (clinical.trials@daytonncorp.org) |
| Rice Memorial Hospital Willmar, Minnesota | - (mmcorc@healthpartners.com) |
| Ridgeview Medical Center Waconia, Minnesota | - (mmcorc@healthpartners.com) |
| Rocky Mountain Cancer Centers - Centennial Centennial, Colorado | - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Aurora Aurora, Colorado | - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Boulder Boulder, Colorado | - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Littleton Littleton, Colorado | - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Midtown Denver, Colorado | - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Rose Denver, Colorado | - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado | - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Thornton Thornton, Colorado | - (info@westernstatesncorp.org) |
| Rush-Copley Healthcare Center Yorkville, Illinois | - (Cancer.Research@rushcopley.com) |
| Rush-Copley Medical Center Aurora, Illinois | - (Cancer.Research@rushcopley.com) |
| SIH Cancer Institute Carterville, Illinois | - (clinical.research@sih.net) |
| SMC Center for Hematology Oncology Union Union, South Carolina | - (kmertz-rivera@gibbscc.org) |
| SSM Health Good Samaritan Mount Vernon, Illinois | - (gayla.hall@ssmhealth.com) |
| Saint Agnes Medical Center Fresno, California | - (medresearch@samc.com) |
| Saint Alphonsus Cancer Care Center-Baker City Baker City, Oregon | - (mccinfo@mtcancer.org) |
| Saint Alphonsus Cancer Care Center-Boise Boise, Idaho | - (stephanie.couch@stjoeshealth.org) |
| Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho | - (stephanie.couch@stjoeshealth.org) |
| Saint Alphonsus Cancer Care Center-Nampa Nampa, Idaho | - (mccinfo@mtcancer.org) |
| Saint Alphonsus Cancer Care Center-Ontario Ontario, Oregon | - (mccinfo@mtcancer.org) |
| Saint Anthony North Hospital Westminster, Colorado | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Anthony's Hospital Cancer Care Center St. Petersburg, Florida | - (Research.CTO@baycare.org) |
| Saint Elizabeth Youngstown Hospital Youngstown, Ohio | - (clinical.trials@daytonncorp.org) |
| Saint Francis Cancer Center Greenville, South Carolina | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Francis Cancer Center Greenville, South Carolina | - (melissa_beckman@bshsi.org) |
| Saint Francis Hospital Greenville, South Carolina | - (melissa_beckman@bshsi.org) |
| Saint Francis Regional Medical Center Shakopee, Minnesota | - (mmcorc@healthpartners.com) |
| Saint Helena Hospital St. Helena, California | - (Kpoct@kp.org) |
| Saint Helena Hospital St. Helena, California | |
| Saint John's Hospital - Healtheast Maplewood, Minnesota | - (mmcorc@healthpartners.com) |
| Saint Joseph Hospital East Lexington, Kentucky | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph London London, Kentucky | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Mount Sterling Mount Sterling, Kentucky | - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph's Hospital/Children's Hospital-Tampa Tampa, Florida | - (jennifer.manns@baycare.org) |
| Saint Joseph's Medical Center Stockton, California | |
| Saint Joseph's/Candler - Bluffton Campus Bluffton, South Carolina | - (underberga@sjchs.org) |
| Saint Louis Cancer and Breast Institute-Ballwin Ballwin, Missouri | |
| Saint Luke's Hospital of Duluth Duluth, Minnesota | - (kdean@slhduluth.com) |
| Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin | - (ewd_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls, Wisconsin | - (ewd_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin | - (ewd_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan, Wisconsin | - (ewd_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin | - (ewd_research_admin@hshs.org) |
| Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri | |
| Salina Regional Health Center Salina, Kansas | - (mleepers@srhc.com) |
| Sechler Family Cancer Center Lebanon, Pennsylvania | - (doxenberg@wellspan.org) |
| Sheboygan Physicians Group Sheboygan, Wisconsin | - (ewd_research_admin@hshs.org) |
| Shenandoah Oncology PC Winchester, Virginia | - (William.Houck@usoncology.com) |
| Sinai Hospital of Baltimore Baltimore, Maryland | - (pridgely@lifebridgehealth.org) |
| South Carolina Cancer Specialists PC Hilton Head Island, South Carolina | - (underberga@sjchs.org) |
| South Florida Baptist Hospital Plant City, Florida | - (Claudia.Quinones@baycare.org) |
| Southern Illinois University School of Medicine Springfield, Illinois | |
| Spartanburg Medical Center Spartanburg, South Carolina | - (kmertz-rivera@gibbscc.org) |
| Springfield Clinic Springfield, Illinois | |
| Springfield Memorial Hospital Springfield, Illinois | - (pallante.beth@mhsil.com) |
| Straub Benioff Medical Center Honolulu, Hawaii | |
| Straub Pearlridge Clinic ‘Aiea, Hawaii | |
| Strecker Cancer Center-Belpre Belpre, Ohio | - (Jeffh@columbusccop.org) |
| Swedish Cancer Institute-Edmonds Edmonds, Washington | - (PCRC-NCORP@Swedish.org) |
| Swedish Cancer Institute-Issaquah Issaquah, Washington | - (PCRC-NCORP@Swedish.org) |
| Swedish Medical Center-First Hill Seattle, Washington | - (PCRC-NCORP@Swedish.org) |
| The Queen's Medical Center - West Oahu ‘Ewa Beach, Hawaii | - (rohta@queens.org) |
| The Radiation Oncology Center-Hilton Head/Bluffton Hilton Head Island, South Carolina | - (underberga@sjchs.org) |
| The University of Kansas Cancer Center - Olathe Olathe, Kansas | - (OlatheCCResearch@kumc.edu) |
| ThedaCare Cancer Care - Berlin Berlin, Wisconsin | - (ResearchDept@thedacare.org) |
| ThedaCare Cancer Care - New London New London, Wisconsin | - (ResearchDept@thedacare.org) |
| ThedaCare Cancer Care - Oshkosh Oshkosh, Wisconsin | - (ResearchDept@thedacare.org) |
| ThedaCare Cancer Care - Shawano Shawano, Wisconsin | - (ResearchDept@thedacare.org) |
| ThedaCare Cancer Care - Waupaca Waupaca, Wisconsin | - (ResearchDept@thedacare.org) |
| ThedaCare Regional Cancer Center Appleton, Wisconsin | - (ResearchDept@thedacare.org) |
| ThedaCare Regional Medical Center - Neenah Neenah, Wisconsin | - (ResearchDept@thedacare.org) |
| Tidelands Georgetown Memorial Hospital Georgetown, South Carolina | - (broe@tidelandshealth.org) |
| Trinity Health Grand Rapids Hospital Grand Rapids, Michigan | - (crcwm-regulatory@crcwm.org) |
| Trinity Health Muskegon Hospital Muskegon, Michigan | - (crcwm-regulatory@crcwm.org) |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan | - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan | - (MCRCwebsitecontactform@stjoeshealth.org) |
| Tripler Army Medical Center Honolulu, Hawaii | |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny, Iowa | |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines, Iowa | |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines, Iowa | |
| UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee, Iowa | |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa | |
| UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie, Maryland | |
| UM Saint Joseph Medical Center Towson, Maryland | - (Jeanmarie.downing@umm.edu) |
| United Hospital Saint Paul, Minnesota | - (mmcorc@healthpartners.com) |
| University Health Truman Medical Center Kansas City, Missouri | |
| University of Iowa Healthcare Cancer Services Quad Cities Bettendorf, Iowa | - (katherine-daprile@uiowa.edu) |
| University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa | |
| University of Kansas Cancer Center - Briarcliff Kansas City, Missouri | |
| University of Kansas Cancer Center - Lee's Summit Lee's Summit, Missouri | - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center - North Kansas City, Missouri | - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center-Overland Park Overland Park, Kansas | - (KUCC_Navigation@kumc.edu) |
| University of Kansas Health System Saint Francis Campus Topeka, Kansas | |
| University of Kansas Hospital-Indian Creek Campus Overland Park, Kansas | - (KUCC_Navigation@kumc.edu) |
| University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas | - (KUCC_Navigation@kumc.edu) |
| University of Maryland/Greenebaum Cancer Center Baltimore, Maryland | |
| University of Michigan Health - West Wyoming, Michigan | - (crcwm-regulatory@crcwm.org) |
| University of New Mexico Cancer Center Albuquerque, New Mexico | - (HSC-ClinicalTrialInfo@salud.unm.edu) |
| University of Wisconsin Carbone Cancer Center - University Hospital Madison, Wisconsin | - (clinicaltrials@cancer.wisc.edu) |
| VCU Community Memorial Health Center South Hill, Virginia | - (nemer.elmouallem@vcuhealth.org) |
| VCU Massey Cancer Center at Stony Point Richmond, Virginia | - (ctoclinops@vcu.edu) |
| Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin | - (ncorp@aurora.org) |
| Vince Lombardi Cancer Clinic-Sheboygan Sheboygan, Wisconsin | - (ncorp@aurora.org) |
| Vince Lombardi Cancer Clinic-Two Rivers Two Rivers, Wisconsin | - (ncorp@aurora.org) |
| Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia | - (CTOclinops@vcu.edu) |
| Wake Forest NCORP Research Base Winston-Salem, North Carolina | Glenn Lesser, MD - (ncorp@wakehealth.edu) Beth Reboussin, PhD - (ncorp@wakehealth.edu) |
| Wake Forest University Health Sciences Winston-Salem, North Carolina | |
| Wake Forest University at Clemmons Clemmons, North Carolina | |
| WellSpan Medical Oncology and Hematology Chambersburg, Pennsylvania | |
| Wellspan Health - York Cancer Center York, Pennsylvania | |
| West Michigan Cancer Center Kalamazoo, Michigan | - (crcwm-regulatory@crcwm.org) |
| Westfields Hospital/Cancer Center of Western Wisconsin New Richmond, Wisconsin | - (mmcorc@healthpartners.com) |
| Wilcox Memorial Hospital and Kauai Medical Clinic Lihue, Hawaii | |
| William E Kahlert Regional Cancer Center/Sinai Hospital Westminster, Maryland | |
| Winter Haven Hospital Winter Haven, Florida | - (Research.CTO@baycare.org) |
| Woodland Cancer Care Center Michigan City, Indiana | - (sally.arnett@franciscanalliance.org) |
| Woodland Memorial Hospital Woodland, California | - (ResearchInstituteInquiries@CommonSpirit.org) |
NS-089/NCNP-02-201 in Boys With Duchenne Muscular Dystrophy (DMD)
Trial info - trialinfo@nspharma.com
NCT05996003
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Inclusion Criteria:
* Male ≥ 4 years and \<15 years of age
* Confirmed DMD mutation(s) in the dystrophin gene that is amenable to skipping of exon 44 to restore the dystrophin mRNA reading frame
* Able to walk independently without assistive devices
* Ability to complete the TTSTAND without assistance in \<20 seconds
* Stable dose of glucocorticoid for at least 3 months and the dose is expected to remain on a stable dose for the duration of the study.
* Other inclusion criteria may apply.
Exclusion Criteria:
* Has a body weight of \<20 kg at the time of informed consent (applies to participants screening for Part 1 only)
* Evidence of symptomatic cardiomyopathy
* Current or previous treatment with anabolic steroids (e.g., oxandrolone) or products containing resveratrol or adenosine triphosphate within 3 months prior to first dose of study drug
* Current or previous treatment with any other investigational drug within 3 months prior to the first dose of study drug or within 5 times the half-life of a medication, whichever is longer
* Surgery within the 3 months prior to the first dose of study drug or planned during the study duration
* Previously treated in an interventional study of NS-089/NCNP-02
* Having received exon skipping oligonucleotide within 1 year prior to the first dose of IP
* Other exclusion criteria may apply. DRUG: NS-089/NCNP-02
Duchenne Muscular Dystrophy, Exon 44, DMD
Exon 44 Skipping, DMD, Brogidirsen
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Show 25 locations
Study Locations
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| Location | Contacts |
|---|---|
| Alberta Children's Hospital Calgary, Alberta | Julie Dao - (julie.dao@ucalgary.ca) |
| Ankara Bilkent City Hospital Ankara, | Gozde Akgun - (gozde.akgun@medex-smo.com) |
| Ann and Robert H. Lurie Children's Hospital of Chicago Chicago, Illinois | Raven Hill - (rhill@luriechildrens.org) Alka Maheshwari - (amaheshwari@luriechildrens.org) |
| British Columbia Children's Hospital Vancouver, British Columbia | Gabe Massarotto - (gabe.massarotto@cw.bc.ca) |
| Children's Hospital Colorado Aurora, Colorado | Hannah Kleiner - (hannah.kleiner@childrenscolorado.org) |
| Cincinnati Children's Hospital Medical Center Cincinnati, Ohio | Angela Edmondson - (Angela.Edmondson@cchmc.org) |
| Fukui Prefectural Hospital Fukui-shi, Fukui | |
| London Health Sciences Centre London, Ontario | Rhiannon Hicks - (rhiannon.hicks@lhsc.on.ca) |
| NHO Osaka Toneyama Medical Center Toyonaka, Osaka | Clinical Trial Office - (410-chiken@mail.hosp.go.jp) |
| National Center of Neurology and Psychiatry Tokyo, | |
| National Hospital Organization Nagara Medical Center Nagara, Gifu-shi, Gifu | Clinical Trial Management Office - (yonekura.kei.wu@mail.hosp.go.jp) |
| Perth Children's Hospital Perth, Western Australia | Jane Jones - (Jane.Jones2@health.wa.gov.au) |
| Pusan National University Yangsan Hospital Yangsan, | JaeYoon Kim - (lusterwuzz@naver.com) |
| Rare Disease Research Atlanta, Georgia | Julia Zhu - (julia.zhu@rarediseaseresearch.com) |
| Rare Disease Research, LLC - FL Kissimmee, Florida | Marcial Almaraz - (marcial.almaraz@rarediseaseresearch.com) |
| S.B.U. Dr. Behcet uz Pediatric Diseases and Surgery Training and Research Hospital Izmir, | Zeynep Erturk - (zeyneperturk@ascotscience.com) |
| Seoul National University Hospital Seoul, Seoul Teugbyeolsi | Hyeon Ju Kwon - (hjkwon@snuh.org; 49041@snuh.org) |
| Shiga General Hospital Moriyama-shi, Shiga | Children's Building - (kenji.s.address@gmail.com) |
| Starship Children's Hospital Auckland, | Margaret Joppa - (mjoppa@adhb.govt.nz) |
| The Children's Hospital of Philadelphia (CHOP) Philadelphia, Pennsylvania | Karen Monono - (mononok@email.chop.edu) |
| UT Southwestern/Children's Health Dallas, Texas | Deniece Winston - (Deniece.Winston@UTSouthwestern.edu) |
| University of Kansas Medical Center (KUMC) Kansas City, Kansas | Rebecca Clay - (rclay@kumc.edu) |
| University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania | Vibha Chauhan - (vibha.chauhan@chp.edu) |
| Virginia Commonwealth University Health System Richmond, Virginia | Andrea Jewell - (andrea.jewell@vcuhealth.org) |
| Yeditepe University Kosuyolu Hospital Istanbul, | Onur Güner - (onurguner@ascotscience.com) |
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer (SUNRAY-02)
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or - LillyTrials@Lilly.com
NCT06890598
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Inclusion Criteria:
* Histological or cytological confirmation of NSCLC.
* Part A
• Clinical Stage II-IIIB (N2) treated with presurgical chemoimmunotherapy, with residual tumor present at time of surgery. Patients with a pathologic complete response are not eligible.
• Pathologic Stage II-IIIB (N2) NSCLC treated with initial upfront resection. * Part B - Clinical Stage III, unresectable NSCLC, without progression on concurrent platinum-based chemoradiotherapy. * Must have disease with evidence of KRAS G12C mutation. * Must have known programmed death-ligand 1 (PD-L1) expression * Must have an ECOG performance status of 0 or 1. * Able to swallow oral medication. * Must have adequate laboratory parameters. * Contraceptive use should be consistent with local regulations for those participating in clinical studies. * Women of childbearing potential must * Have a negative pregnancy test. * Not be breastfeeding during treatment
Exclusion Criteria:
* Have known changes in the EGFR or ALK genes.
* Have another type of cancer that is progressing or required active treatment within the past 2 years before screening.
* Have an active autoimmune disease that required systemic treatment in the past 2 years. Endocrine replacement therapy is allowed.
* Had any immune-related side effect or allergic reaction (Grade 3 or higher) from a previous immunotherapy medicine, or any immune-related side effect greater than Grade 1 that has not resolved. This does not apply for people with hormone-related diseases who are now on stable hormone replacement therapy. DRUG: Olomorasib, DRUG: Pembrolizumab, DRUG: Durvalumab, DRUG: Placebo
Carcinoma, Non-Small-Cell Lung
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Show 361 locations
Study Locations
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| Location | Contacts |
|---|---|
| AHN Allegheny General Hospital Pittsburgh, Pennsylvania | |
| ASST Grande Ospedale Metropolitano Niguarda Milan, | |
| AZ Delta vzw Roeselare, | |
| Adana City Hospital Adana, | |
| Agios Loukas Clinic Thessaloniki, | |
| Agios Savvas Regional Cancer Hospital Athens, | |
| Aichi Cancer Center Hospital Nagoya, | |
| Amphia Ziekenhuis, locatie Breda Molengracht Breda, | |
| Amsterdam UMC, locatie VUmc Amsterdam, | |
| Antalya Egitim ve Arastırma Hastanesi Antalya, | |
| Antwerp University Hospital Edegem, | |
| Anyang Cancer Hospital Anyang, | |
| Asan Medical Center Seoul, | |
| Asklepios Fachkliniken München-Gauting Gauting, | |
| Asklepios Klinik Harburg Hamburg, | |
| Assistance Publique Hopitaux de Marseille - Hopital Nord Marseille, | |
| Aultman Hospital Canton, Ohio | |
| Austin Health Heidelberg, Victoria | |
| Azienda Ospedaliera Dei Colli Naples, | |
| Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento Verona, | |
| Azienda Sanitaria Ospedaliera S Luigi Gonzaga Orbassano, | |
| BASS Cancer Center Walnut Creek, California | |
| Baptist Health Hamburg Lexington, Kentucky | |
| Baptist Health Lexington Lexington, Kentucky | |
| Baskent University Dr. Turgut Noyan Research and Training Center Adana, | |
| Beijing Cancer Hospital Beijing, | |
| Boca Raton Regional Hospital Boca Raton, Florida | |
| Bradfordhill Santiago, | |
| Budapesti Uzsoki Utcai Korhaz Budapest, | |
| Buddhist Dalin Tzu Chi General Hospital Chiayi City, | |
| CHI Saint Joseph Cancer Center - East Lexington, Kentucky | |
| CHIREC - site delta Auderghem, | |
| CHU Bordeaux Haut-Leveque Pessac, | |
| CHU Grenoble Alpes La Tronche, | |
| CHU de Toulouse - Hopital Larrey Toulouse, | |
| CHUS - Hospital Clinico Universitario Santiago de Compostela, | |
| CTO - Centro de Tratamento Oncológico Belém, | |
| Cancer Care Northwest - Vercler Spokane Valley, Washington | |
| Cancer Hospital Chinese Academy of Medical Science Beijing, | |
| Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center Shenzhen, | |
| Cancer Hospital of Shantou University Medical College Shantou, | |
| Captain James A. Lovell Federal Health Care Center North Chicago, Illinois | |
| Centre Antoine-Lacassagne Nice, | |
| Centre Hospitalier Universitaire de Poitiers Poitiers, | |
| Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou Rennes, | |
| Centre Leon Berard Lyon Cedex08, | |
| Centro Hospitalar E Universitário De Coimbra Coimbra, | |
| Centro Paulista de Oncologia Clínica São Paulo, | |
| Centro de Oncología de Precisión Santiago, | |
| Centro de Pesquisa Clínica do Instituto do Câncer do Ceará Fortaleza, | |
| Centro de Pesquisa Sao Lucas Campinas, | |
| Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA Rio de Janeiro, | |
| Chang Gung Medical Foundation-LinKou Branch Taoyuan, | |
| Chang Gung Memorial Hospital at Kaohsiung Kaohsiung Niao Sung Dist, | |
| Changhua Christian Hospital Changhua County, | |
| Charite Campus Virchow-Klinikum Berlin, | |
| Chi Mei Hospital - Liouying Branch Tainan, | |
| Chi Mei Medical Center Tainan, | |
| China-Japan Friendship Hospital Beijing, | |
| Chonnam National University Hwasun Hospital Hwasun, | |
| Chung Shan Medical University Hospital Taichung, | |
| Chungbuk National University Hospital Cheongju-si, | |
| City of Hope National Medical Center, Atlanta Cancer Center Newnan, Georgia | |
| City of Hope, Chicago Chicago, Illinois | |
| City of Hope, Phoenix Phoenix, Arizona | |
| Clearview Cancer Institute Huntsville, Alabama | |
| Cleveland Clinic Cleveland, Ohio | |
| Columbia University Irving Medical Center New York, New York | |
| Complejo Hospitalario de Navarra Pamplona, | |
| Comprehensive Hematology Oncology St. Petersburg, Florida | |
| DRK Kliniken Berlin Mitte Berlin, | |
| Deenanath Mangeshkar Hospital & Research Centre Pune, | |
| Drammen Sykehus, Vestre Viken HF Drammen, | |
| E-DA Hospital Kaohsiung City, | |
| ETZ Elisabeth Tilburg, | |
| Errikos Dunant Hospital Center Athens, | |
| European Interbalkan Medical Center Thessaloniki, | |
| Evangelische Lungenklinik Berlin Berlin, | |
| Evangelisches Krankenhaus Herne - Eickel Herne, | |
| FALP Santiago, | |
| Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica Banská Bystrica, | |
| Fakultni nemocnice Bulovka Prague, | |
| Far Eastern Memorial Hospital New Taipei City, | |
| Farkasgyepui Tudogyogyintezet Farkasgyepű, | |
| Florida Cancer Specialists - South Fort Myers, Florida | |
| Florida Cancer Specialists East West Palm Beach, Florida | |
| Florida Cancer Specialists North St. Petersburg, Florida | |
| Franciscan Health Indianapolis, Indiana | |
| Franziskus-Hospital Harderberg Georgsmarienhütte, | |
| Fudan University Shanghai Cancer Center Shanghai, Shanghai Municipality | |
| Fundação Pio XII - Hospital de Câncer de Barretos Barretos, | |
| Galaxy Superspeciality Hospital Aurangabad, | |
| Gangnam Severance Hospital, Yonsei University Health System Gangnam-gu, | |
| Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi Gaziantep, | |
| Goulburn Valley Health Shepparton, | |
| Groupe hospitalier Paris saint Joseph Paris, | |
| Guangdong Provincial People's Hospital Guangzhou, | |
| Guangxi Medical University Affiliated Tumor Hospital Nanning, | |
| Gustave Roussy Villejuif, | |
| H.R.U Málaga - Hospital General Málaga, | |
| HELIOS Klinikum Erfurt Erfurt, | |
| HFR Fribourg - Hôpital cantonal Fribourg, | |
| Harbin Medical University Cancer Hospital Harbin, | |
| Hartford Hospital (HH) Hartford, Connecticut | |
| Haukeland Universitetssjukehus Bergen, | |
| Heartlands Hospital Birmingham, | |
| Hemato Oncology Clinic Ahmedabad, | |
| Highlands Oncology Group Springdale, Arkansas | |
| Himeji Medical Center Himeji, | |
| Hokkaido University Hospital Sapporo, | |
| Hospices Civils de Lyon - Hopital Louis Pradel Bron, | |
| Hospital Clinic de Barcelona Barcelona, | |
| Hospital Clinico Universitario Lozano Blesa Zaragoza, | |
| Hospital Clinico de Valencia Valencia, | |
| Hospital Cuf porto Porto, | |
| Hospital General Universitario Gregorio Marañon Madrid, | |
| Hospital Infanta Cristina Badajoz, | |
| Hospital Insular de Gran Canaria Las Palmas de Gran Canaria, | |
| Hospital Jerez de la Frontera Jerez de la Frontera, | |
| Hospital Santa Catarina - Paulista São Paulo, | |
| Hospital Sao Lucas da PUCRS Porto Alegre, | |
| Hospital Sirio Libanes São Paulo, | |
| Hospital Tacchini Bento Gonçalves, | |
| Hospital Universitari Son Espases Palma, | |
| Hospital Universitari Vall d'Hebron Barcelona, | |
| Hospital Universitario 12 de Octubre Madrid, | |
| Hospital Universitario Quironsalud Madrid Pozuelo de Alarcón, | |
| Hospital Universitario Ramon y Cajal Madrid, | |
| Hospital Universitario Virgen del Rocio Seville, | |
| Hospital da Luz Lisboa Lisbon, | |
| Hospital de Cancer de Londrina Londrina, | |
| Houston Methodist Hospital Houston, Texas | |
| Hualien Tzu Chi Medical Center Hualien City, | |
| Hubei Cancer Hospital Wuhan, | |
| Huddersfield Royal Infirmary Huddersfield, | |
| Hunan Cancer Hospital Changsha, | |
| Hunan Cancer Hospital Changsha, | |
| Hôpital Européen Georges Pompidou Paris, | |
| Hôpital Robert Schuman Vantoux, | |
| ICON Cancer Centre - Kurralta Park Kurralta Park, | |
| Icesp - Instituto Do Câncer Do Estado de São Paulo São Paulo, | |
| Icon Cancer Centre Wesley Auchenflower, | |
| Infirmary Cancer Care Mobile, Alabama | |
| Institut Curie Paris, | |
| Institut Jean Godinot Reims, | |
| Institut de Cancerologie de l'Ouest Saint-Herblain, | |
| Instituto Catalan de Oncologia - Hospital Duran i Reynals Hospitalet, | |
| Instituto D'Or Pesquisa e Ensino Rio de Janeiro, | |
| Instituto D'Or de Pesquisa e Ensino (IDOR) São Paulo, | |
| Instituto Português de Oncologia do Porto Francisco Gentil, EPE Porto, | |
| Instituto Tumori Giovanni Paolo II Bari, | |
| Institutul Oncologic Cluj-Napoca, | |
| Isala, locatie Zwolle Zwolle, | |
| Istituto Nazionale Tumori Regina Elena Rome, | |
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola, | |
| Izmir Atatürk Training and Research Hospital Izmir, | |
| James M Stockman Cancer Institute Frederick, Maryland | |
| Jefferson Health - Cherry Hill Cherry Hill, New Jersey | |
| Jefferson Hospital Northeast Philadelphia, Pennsylvania | |
| Jilin Cancer Hospital Changchun, Jilin | |
| Jinan Central Hospital Jinan, | |
| Johns Hopkins Bayview Medical Center Baltimore, Maryland | |
| Juntendo University Hospital Bunkyō City, | |
| K2 Oncology Providencia, | |
| Kaiser Permanente Interstate Medical Office Central Portland, Oregon | |
| Kaiser Permanente San Diego Mission Road San Diego, California | |
| Kanagawa Cancer Center Yokohama, | |
| Kanagawa Cardiovascular and Respiratory Center Yokohama, | |
| Kanazawa University Hospital Kanazawa, | |
| Kansai Medical University Hospital Hirakata, | |
| Kantonsspital Baden Baden, | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung City, | |
| Karmanos Cancer Institute Detroit, Michigan | |
| Keimyung University Dongsan Hospital Daegu, | |
| Kindai University Hospital- Osakasayama Campus Sakai, | |
| Klinik Floridsdorf Vienna, | |
| Klinikum Chemnitz Chemnitz, | |
| Klinikum Nürnberg Nord Nuremberg, | |
| Konkuk University Medical Center Seoul, | |
| Korea University Guro Hospital Seoul, | |
| Kouros Moccia Oncologia Locarno, | |
| Krankenhaus Martha-Maria Halle-Dölau Halle, | |
| Kyungpook National University Chilgok Hospital Deagu, | |
| Kyushu University Hospital Fukuoka, | |
| Lahey Hospital & Medical Center Burlington, Massachusetts | |
| Latrobe Regional Health Traralgon, | |
| Lexington Medical Center West Columbia, South Carolina | |
| Liga Norte Riograndense Contra O Cancer Natal, | |
| Liuzhou People's Hospital Liuzhou, | |
| Lotus-Med Bucharest, | |
| LungenClinic Grosshansdorf Großhansdorf, | |
| MV-Zentrum für Onkologie und Hämatologie Cologne, | |
| Maastricht UMC+ Maastricht, | |
| Malabar Cancer Centre - Thalassery Thalassery, | |
| Marmara Universitesi Pendik Egitim Arastirma Hastanesi Pendik, | |
| Mary Bird Perkins Cancer Center Baton Rouge, Louisiana | |
| Medical College of Wisconsin Milwaukee, Wisconsin | |
| Medical University of South Carolina Charleston, South Carolina | |
| Medipoint Hospitals Pvt. Ltd. Pune, | |
| Medizinische Universität Graz Graz, | |
| Meir Medical Center Kfar Saba, | |
| Memorial Sloan Kettering Cancer Center New York, New York | |
| Miami Cancer Institute at Baptist Health, Inc. Miami, Florida | |
| Miami Valley Hospital South Centerville, Ohio | |
| Missouri Baptist Medical Center St Louis, Missouri | |
| Miyagi Cancer Center Natori, | |
| Moffitt Cancer Center Tampa, Florida | |
| NHO Kinki Chuo Chest Medical Center Sakai, | |
| National Cancer Center Goyang-si, | |
| National Cancer Center Hospital East Kashiwa, | |
| National Cheng Kung University Hospital Tainan, | |
| National Taiwan University Cancer Center (NTUCC) Taipei, | |
| National Taiwan University Hospital Taipei, | |
| National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region Douliu, | |
| Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL) Amsterdam, | |
| Nemocnice AGEL Ostrava - Vitkovice a.s. Ostrava, | |
| New England Cancer Specialists Westbrook, Maine | |
| New Taipei Municipal TuCheng Hospital New Taipei City, | |
| Niigata Cancer Center Hospital Niigata, | |
| Northport VA Medical Center Northport, New York | |
| Northwest Cancer Specialists PC Vancouver, Washington | |
| Northwestern Memorial Hospital Chicago, Illinois | |
| OSF Saint Francis Medical Center Peoria, Illinois | |
| Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala Ocala, Florida | |
| Ochsner Clinic Foundation New Orleans, Louisiana | |
| Ochsner Health Ochsner Cancer Center - Baton Rouge Baton Rouge, Louisiana | |
| Oncocentro de Minas Gerais Belo Horizonte, | |
| One Day Med Szczecin, | |
| Onkologiezentrum Donauwörth Donauwörth, | |
| Ordensklinikum Linz GmbH Elisabethinen Linz, | |
| Oregon Health and Science University Portland, Oregon | |
| Orszagos Onkologiai Intezet Budapest, | |
| Oslo universitetssykehus, Radiumhospitalet Oslo, | |
| Ospedale San Gerardo-ASST Monza Monza, | |
| Ospedale San Martino Genova, | |
| Ovidius Clinical Hospital OCH Ovidiu, | |
| Pacific Medical College & Hospital Udaipur, | |
| Parc de Salut Mar - Hospital del Mar Barcelona, | |
| Parkview Research Center at Parkview Regional Medical Center Fort Wayne, Indiana | |
| Peking University People's Hospital Beijing, | |
| Policlinico "G. Rodolico" Catania, | |
| Profound Research LLC Oceanside, California | |
| Providence Portland Medical Center Portland, Oregon | |
| Providence St. Vincent Medical Center Portland, Oregon | |
| Pusan National University Hospital Seogu, Busan Gwang'yeogsi | |
| Pusan National University Yangsan Hospital Yangsan, | |
| Rajiv Gandhi Government General Hospital Chennai, | |
| Rambam Health Care Campus Haifa, | |
| Regional Cancer Centre - Thiruvananthapuram Thiruvananthapuram, | |
| Reliant Medical Group Worcester, Massachusetts | |
| Robert Bosch Krankenhaus GmbH Stuttgart, | |
| Royal Marsden Hospital (Chelsea) London, | |
| Royal Marsden Hospital (Sutton) London, | |
| SC Memorial Healthcare International SRL Bucharest, | |
| SCRI Oncology Partners Nashville, Tennessee | |
| Sahlgrenska Universitetssjukhuset Gothenburg, | |
| Saitama Medical University International Medical Center Hidaka, | |
| Sakarya University School of Medicine Adapazarı, | |
| Samsun Medical Park Hastanesi Samsun, | |
| Samsung Medical Center Seoul, | |
| Sarah Cannon Research Institute Nashville, Tennessee | |
| Savera Cancer & Multi Speciality Hospital Patna, | |
| Seoul National University Bundang Hospital Seongnam-si, Gyeonggi-do | |
| Severance Hospital, Yonsei University Health System Seoul, | |
| Shaare Zedek Medical Center Jerusalem, | |
| Shandong Cancer Hospital Jinan, | |
| Shanghai Chest Hospital Shanghai, | |
| Sheba Medical Center Ramat Gan, | |
| Shenzhen People's Hospital Shenzhen, | |
| Shizuoka Cancer Center Nagaizumi-cho,Sunto-gun, | |
| Sibley Memorial Hospital Washington D.C., District of Columbia | |
| Sichuan Cancer Hospital Chengdu, | |
| Sidney Kimmel Cancer Center - Washington Township Sewell, New Jersey | |
| Sir Charles Gairdner Hospital Perth, | |
| Sir H. N. Reliance Foundation Hospital and Research Centre Mumbai, | |
| Sorlandet Sykehus Arendal Arendal, | |
| Springfield Clinic Main Campus Springfield, Illinois | |
| St. Antonius Ziekenhuis, locatie Utrecht Utrecht, | |
| St. Elisabeth-Krankenhaus Leipzig Leipzig, | |
| Stanford Cancer Center Palo Alto, California | |
| Sunshine Coast University Hospital Birtinya, | |
| Swedish Cancer Institute - Edmonds Edmonds, Washington | |
| Swedish Medical Center Seattle, Washington | |
| Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej Kielce, | |
| Sykehuset Innlandet HF Gjøvik Gjøvik, | |
| Taichung Veterans General Hospital Taichung, | |
| Taipei Veterans General Hospital Taipei, | |
| Taizhou Hospital of Zhejiang Province Linhai, | |
| Tamworth Hospital North Tamworth, | |
| Tata Memorial Centre - Homi Bhabha Cancer Hospital Varanasi, | |
| Tennessee Oncology Nashville, Tennessee | |
| Tennessee Oncology Chattanooga Chattanooga, Tennessee | |
| Thangam Cancer Center - Namakkal Namakkal, | |
| The Cancer Institute Hospital of JFCR Koto-ku, Tokyo | |
| The Catholic Univ. of Korea Seoul St. Mary's Hospital Seoul, | |
| The Catholic University Of Korea St. Vincent's Hospital Suwon, | |
| The Catholic University of Korea, Eunpyeong St. Mary's Hospital Seoul, | |
| The Catholic University of Korea, Incheon St. Mary's Hospital Bupyeong-gu, | |
| The Catholic University of Korea, Yeouido St. Mary's Hospital Seoul, | |
| The Center for Cancer and Blood Disorders Fort Worth, Texas | |
| The Christie NHS Foundation Trust Manchester, | |
| The First Affiliated Hospital of Guangzhou Medical University Guangzhou, | |
| The First Affiliated Hospital of Henan University of Science &Technology Luoyang, | |
| The First Affiliated Hospital of Soochow University Suzhou, Jiangsu | |
| The First Affiliated Hospital of Xi'An Jiaotong University Xi'an, | |
| The First People's Hospital of Foshan Foshan, | |
| The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T Columbus, Ohio | |
| The Second Affiliated Hospital Chongqing Medical University Chongqing, | |
| The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou, | |
| The Second People's Hospital of Neijiang Neijiang, | |
| The Third People's Hospital of Chengdu (CDTPH) Chengdu, | |
| The University of Arizona Cancer Center - North Campus Tucson, Arizona | |
| The University of Vermont Medical Center Inc. Burlington, Vermont | |
| Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office Philadelphia, Pennsylvania | |
| Thoracic General Hospital of Athens "I Sotiria" Athens, | |
| Thoraxklinik-Heidelberg gGmbH Heidelberg, | |
| Tianjin Medical University Cancer Institute & Hospital Tianjin, | |
| Tianjin Medical University Cancer Institute & Hospital Tianjin, | |
| Tokyo Metropolitan Komagome Hospital Bunkyō City, | |
| Tongji Hospital Tongji Medical,Science & Technology Wuhan, | |
| Torbay Hospital Torquay, | |
| Tottori University Hospital Yonago, | |
| Trakya University Edirne, | |
| UCLA Hematology/Oncology - Santa Monica Los Angeles, California | |
| USO - Texas Oncology - San Antonio San Antonio, Texas | |
| USO - Texas Oncology Gulf Coast Sugar Land, Texas | |
| USO - US Oncology Research Network Nashville, Tennessee | |
| UZ Leuven Leuven, | |
| Universitaetsklinikum Tuebingen Tübingen, | |
| University General Hospital of Heraklion Heraklion, | |
| University General Hospital of Larissa Larissa, | |
| University Hospital and UW Health Clinics Madison, Wisconsin | |
| University Hospital of Patras Pátrai, | |
| University Hospital,Kyoto Prefectural University of Medicine Kyoto, | |
| University Hospitals Sussex NHS Foundation Trust East Sussex, | |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center Orange, California | |
| University of Chicago Medical Center Chicago, Illinois | |
| University of Florida - Jacksonville Jacksonville, Florida | |
| University of Health Sciences,Gulhane School of Medicine Ankara, | |
| University of Illinois at Chicago Chicago, Illinois | |
| University of Maryland Baltimore, Maryland | |
| University of Tennessee Medical Center Knoxville, Tennessee | |
| University of Texas MD Anderson Cancer Center Houston, Texas | |
| University of Virginia Health System Charlottesville, Virginia | |
| Univerzitná nemocnica Bratislava - Nemocnica Ružinov Bratislava, | |
| VCU Health Adult Outpatient Pavillion Richmond, Virginia | |
| Vivantes Klinikum im Friedrichshain - Landsberger Allee Berlin, | |
| Vychodoslovensky Onkologicky ustav a.s. Košice, | |
| Wakayama Medical University Hospital Wakayama, | |
| West China Hospital, Sichuan University Chengdu, | |
| Wielkopolskie Centrum Pulmonologii i Torakochirurgii Poznan, | |
| Winship Cancer Institute Atlanta, Georgia | |
| Xiangya Hospital Central South University Changsha, | |
| Yeungnam Univeristy Medical Center Nam-gu, | |
| Zhejiang Cancer Hospital Hangzhou, | |
| Zhejiang Cancer Hospital Hangzhou, | |
| Zhejiang Provincial People's Hospital Hangzhou, | |
| Zhongshan Peoples Hospital Zhongshan, | |
| ZhuZhou Central Hospital Zhuzhou, | |
| Ziekenhuis St. Jansdal Harderwijk, | |
| İ.A.Ü VM Medical Park Florya Hastanesi Istanbul, |
The CONFORM Pivotal Trial
Sarah Gallagher - sgallagher@conformalmedical.com
NCT05147792
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Inclusion Criteria:
• Male or non-pregnant female aged ≥18 years
• Documented non-valvular AF (paroxysmal, persistent, or permanent)
• High risk of stroke or systemic embolism, defined as CHA2DS2-VASc score of ≥ 3
• Has an appropriate rationale to seek a non-pharmacologic alternative to long-term oral anticoagulation
• Deemed by the site investigator to be suitable for short term oral anticoagulation therapy but deemed less favorable for long-term oral anticoagulation therapy.
• Deemed appropriate for LAA closure by the site investigator and a clinician not a part of the procedural team using a shared decision-making process in accordance with standard of care
• Able to comply with the protocol-specified medication regimen and follow-up evaluations
• The subject (or legally authorized representative, where allowed) has been informed of the nature of the study, agrees to its provisions, and has provided written informed consent approved by the appropriate institutional review board (IRB)/Regional Ethics Board (REB)/Ethics Committee (EC).
Exclusion Criteria:
• Pregnant or nursing patients and those who plan pregnancy in the period up to one year following the index procedure. Female patients of childbearing potential must have a negative pregnancy test (per site standard test) within 7 days prior to index procedure.
• Anatomic conditions that would prevent performance of an LAA occlusion procedure (e.g., atrial septal defect (ASD) requiring closure, high-risk patent foramen ovale (PFO) requiring closure, a highly mobile inter-atrial septal aneurysm precluding a safe TSP, presence of a PFO/ASD closure device, history of surgical ASD repair or history of surgical LAAO closure)
• Atrial fibrillation that is defined by a single occurrence or that is transient or reversible (e.g., secondary thyroid disorders, acute alcohol intoxication, trauma, recent major surgical procedures)
• A medical condition (other than atrial fibrillation) that mandates long-term oral anticoagulation (e.g., history of unprovoked deep vein thrombosis or pulmonary embolism, or prosthetic mechanical heart valve)
• History of bleeding diathesis or coagulopathy, or patients in whom antiplatelet and/or anticoagulant therapy is contraindicated
• Documented active systemic infection
• Symptomatic carotid artery disease (defined as \>50% stenosis with symptoms of ipsilateral transient or visual TIA evidenced by amaurosis fugax, ipsilateral hemispheric TIAs or ipsilateral stroke); if subject has a history of carotid stent or endarterectomy the subject is eligible if there is \<50% stenosis noted at the site of prior treatment
• Recent (within 30 days of index procedure) or planned (within 60 days post-procedure) cardiac or major non-cardiac interventional or surgical procedure
• Recent (within 30 days of index procedure) stroke or transient ischemic attack
• Recent (within 30 days of index procedure) myocardial infarction
• Vascular access precluding delivery of implant with catheter-based system
• Severe heart failure (New York Heart Association Class IV)
• Prior cardiac transplant, history of mitral valve replacement or transcatheter mitral valve intervention, or any prosthetic mechanical valve implant
• Renal insufficiency, defined as estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73 m2 (by the Modification of Diet in Renal Disease equation)
• Platelet count \<75,000 cells/mm3 or \>700,000 cells/mm3, or white blood cell count \<3,000 cells/mm3
• Known allergy, hypersensitivity or contraindication to aspirin, heparin, or that would preclude any P2Y12 inhibitor therapy, or to device materials (e.g., nickel, titanium), or the subject has contrast sensitivity that cannot be adequately pre-medicated
• Actively enrolled or plans to enroll in a concurrent clinical study in which the active treatment arm may confound the results of this trial
• Unable to undergo general anesthesia
• Known other medical illness or known history of substance abuse that may cause non-compliance with the protocol or protocol-specified medication regimen, confound the data interpretation, or is associated with a life expectancy of less than 5 years
• A condition which precludes adequate transesophageal echocardiographic assessment Echo exclusion criteria:
• Left atrial appendage anatomy which cannot accommodate a commercially available control device or the CLAAS Implant per manufacturer IFU (e.g., the anatomy and sizing must be appropriate for both the investigational (CLAAS) and a commercially available device in order to be enrolled in the trial)
• Intracardiac thrombus or dense spontaneous echo contrast consistent with thrombus, as visualized by TEE
• Left ventricular ejection fraction (LVEF) \<30%
• Moderate or large pericardial effusion \>10 mm or symptomatic pericardial effusion, signs or symptoms of acute or chronic pericarditis, or evidence of tamponade physiology
• Atrial septal defect that warrants closure
• High risk patent foramen ovale (PFO), defined as an atrial septal aneurysm (excursion \>15 mm or length \> 15 mm) or large shunt (early \[within 3 beats\] and/or substantial passage of bubbles, e.g., \>20)
• Moderate or severe mitral valve stenosis (mitral valve area \<1.5 cm2)
• Complex atheroma with mobile plaque of the descending aorta and/or aortic arch
• Evidence of cardiac tumor
DEVICE: CLAAS, DEVICE: WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder
Atrial Fibrillation, Stroke
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Show 88 locations
Study Locations
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| Location | Contacts |
|---|---|
| AKFA Medline Olmazor, Tashkent | |
| Abrazo Arizona Heart Hospital Phoenix, Arizona | |
| AdventHealth Orlando Orlando, Florida | Chantie Garvey - (chantie.garvey@adventhealth.com) |
| AdventHealth Tampa Tampa, Florida | Daniel Robledo - (daniel.robledo@adventhealth.com) |
| Albany Medical Center / Capital Cardiology Associates Albany, New York | Chris Chapman - (cchapman@capitalcardiology.com) |
| Arizona Heart Arrhythmia Associates Phoenix, Arizona | Helen Foughi - (hfoughi@insightmedr.com) |
| Ascension St. Vincent - Carmel, IN Indianapolis, Indiana | |
| Ascension St. Vincent's Jacksonville Jacksonville, Florida | |
| Banner University Medical Center Phoenix Phoenix, Arizona | Erin Downey - (ErinDowney@Arizona.edu) |
| Baptist Health Care - Pensacola Pensacola, Florida | Bridget Lane - (bridget.lane@bhcpns.org) |
| Baptist Hospital of Miami Miami, Florida | Maria Ardid - (mariaar@baptisthealth.net) |
| Baylor Scott & White Research Institute Plano, Texas | Emmitt Lavergne - (Emmitt.Lavergne@BSWHealth.org) |
| Baystate Medical Center Springfield, Massachusetts | Christine Callahan - (Christine.Callahan@baystatehealth.org) |
| Bellin Health Green Bay, Wisconsin | Katherine Guilliams - (katherine.Guilliams@emplifyhealth.org) |
| CHI Health / CommonSpirit Research Institute Omaha, Nebraska | Barb Lapke - (barb.lapke@commonspirit.org) |
| CHRISTUS Health Tyler, Texas | Jamie-Crystal Wylie - (jamiecrystal.wylie@christushealth.org) |
| CHU La Timone, Marseille Marseille, | Aurélie Blondelon - (aurelie.blondelon@ap-hm.fr) |
| CHU de Bordeaux Bordeaux, | Amandine Ruissel - (amandine.ruissel@chu-bordeaux.fr) |
| CHU de Toulouse Toulouse, | Asmae Hammouda - (hammouda.a@chu-toulouse.fr) |
| Carilion Clinic Roanoke, Virginia | Breanne Dao - (bldao@carilionclinic.org) |
| Catholic Medical Center Manchester, New Hampshire | |
| Centracare Heart and Vascular Center Saint Cloud, Minnesota | Audrey Hillebrand-Raap - (Audrey.Hillenbrand-Raap@centracare.com) |
| Chapidze Heart Disease Center Tbilisi, | |
| Chippenham Hospital Richmond, Virginia | Ariana Dickens - (Ariana.Dickens@hcahealthcare.com) |
| Clinique Pasteur, Toulouse Toulouse, | Fréderique Petit - (fpetit@clinique-pasteur.com) |
| Community Memorial Hospital Ventura Ventura, California | Marisa Grant - (marisa@siteresearchmgmt.com) |
| Cooper University - Heart House Haddon Heights, New Jersey | Kaitlyn Downey - (KDowney@hearthousenj.com) |
| Corewell Health Grand Rapids, Michigan | |
| Emory University Atlanta, Georgia | Katie Shin - (Katie.shin@emory.edu) |
| Erlanger Health System Chattanooga, Tennessee | |
| Grandview Medical Center Birmingham, Alabama | Kristy Raco - (kristy.raco@grandviewhealth.com) |
| HCA Grand Strand Myrtle Beach, South Carolina | Carley Brandli - (Carley.Brandli@hcahealthcare.com) |
| Hackensack University Medical Center Hackensack, New Jersey | |
| Hartford Health Care St. Vincent's Medical Center Bridgeport, Connecticut | Jesse Cardona - (Jesse.cardona@hhchealth.org) |
| Henry Ford Providence Southfield Hospital Southfield, Michigan | Candice Edillo - (cedillo1@hfhs.org) |
| Henry Ford St. John Hospital Grosse Pointe Woods, Michigan | Heather Metcalfe - (hmetcal1@hfhs.org) |
| HonorHealth Scottsdale, Arizona | Ethan Ashley - (eashley@honorhealth.com) |
| Houston Methodist Houston, Texas | Chinwe Ngumezi - (ccngumezi@houstonmethodist.org) |
| Huntington Hospital Huntington, New York | Samia Solh - (Samia.Solh@huntingtonhealth.org) |
| Institut Cardiovasculaire Paris Sud Massy, | Séverine Roger - (s.roger@icps.com.fr) |
| Israeli-Georgian Medical Research Clinic Helsicore Tbilisi, | |
| Johns Hopkins University Baltimore, Maryland | Michele Martucci - (mmill148@jmi.edu) |
| Kansas City Cardiac Arrhythmia Research, LLC Overland, Missouri | Rachael Koeppe - (rachael.koeppe@hcahealthcare.com) |
| Lahey Hospital & Medical Centeer Burlington, Massachusetts | Jean Byrne - (jean.byrne@lahey.org) |
| Lankenau Heart Institute Wynnewood, Pennsylvania | Lucy Delp - (delpl@mlhs.org) |
| Largo Medical Center Upper Marlboro, Maryland | Holly Lynn Grospitch - (HollyLynn.Grospitch@hcahealthcare.com) |
| Lifespan Health System Providence, Rhode Island | |
| Loma Linda University Health Loma Linda, California | Tina Ramirez - (tiramirez@llu.edu) |
| M Health Fairview St. John's Hospital Maplewood, Minnesota | Beth Jorgenson - (beth.jorgenson@fairview.org) |
| MedStar Union Memorial Hospital Baltimore, Maryland | Keith Moyer - (Keith.T.Moyer@medstar.net) |
| Medstar Washington Hospital Center Washington D.C., District of Columbia | Nebu Alexander - (nebu.alexander@medstar.net) |
| Memorial Hermann Memorial City Medical Center Houston, Texas | Maddie Peek - (maddie@whactc.com) |
| Midwest Cardiovascular Institute Naperville, Illinois | Sherri McCoy - (Sherri.McCoy@cardio.com) |
| Mission Hospital Asheville, North Carolina | Christina Riggsbee - (christina.riggsbee@hcahealthcare.com) |
| Mount Sinai Hospital New York, New York | Kyle Reed - (Kyle.Reed@mssm.edu) |
| Nemocnice Na Homolce Prague, | |
| New Mexico Heart Institute Albuquerque, New Mexico | LaTasha Johnson - (latasha.johnson@lovelace.com) |
| North Mississippi Medical Center Tupelo, Mississippi | Kristin Eads - (KEads@nmhs.net) |
| Northside Hospital, Inc Atlanta, Georgia | Troy Crain - (troy.crain@northside.com) |
| Ohio Health Research Institute Columbus, Ohio | |
| Pacific Heart Institute Santa Monica, California | Alette Laughton - (research@pacificheart.com) |
| Piedmont Health Institute Atlanta, Georgia | Megan Kopp - (Megan.Kopp@piedmont.org) |
| Pima Heart & Vascular Tucson, Arizona | Salma Blum - (Salma.Blum@tmcaz.com) |
| Prisma Health Greenville, South Carolina | Amy Wolfe - (Amy.Wolfe@PrismaHealth.org) |
| Promedica Toledo Hospital Toledo, Ohio | Sonya Inderrieden - (Sonya.Inderrieden@ProMedica.org) |
| Republican Specialized Center for Surgery named after V. Vakhidov Chilanzar, Tashkent | |
| Saint Luke's Hospital of Kansas City Kansas City, Missouri | Cheryl Rutherford - (cjrutherford@saint-lukes.org) |
| Sarasota Memorial Health Care System Sarasota, Florida | Kristen Sangmaster - (kristen-sangmaster@smh.com) |
| Sentara Norfolk Norfolk, Virginia | |
| South Denver Cardiology Associates Littleton, Colorado | Sarah Neilsen - (sneilsen@southdenver.com) |
| St. Bernard's Medical Center Jonesboro, Arkansas | Kayla Rubino - (krubino@dnairresearch.com) |
| Tbilisi Heart Center Tbilisi, | |
| Tbilisi Heart and Vascular Clinic Tbilisi, | |
| Tennova Healthcare - Turkey Creek Medical Center Knoxville, Tennessee | Juliana Bailey - (juliana.bailey@tennova.com) |
| Terrebone - Cardiovascular Institute of the South Houma, Louisiana | Vicky Parfait - (vicky.parfait@cardio.com) |
| TriHealth Cincinnati, Ohio | Marta McClellan - (Marta_McClellan@trihealth.com) |
| Trident Medical Center North Charleston, South Carolina | Danielle Pagan - (danielle.pagan@hcahealthcare.com) |
| UPMC Harrisburg Mechanicsburg, Pennsylvania | Matthew Rutt - (ruttmd4@upmc.edu) |
| USF - Tampa General Hospital Tampa, Florida | Jacky He - (jackyhe@usf.edu) |
| University of Buffalo / Kaleida Health Buffalo, New York | Lindsay Moshides - (lmoshide@buffalo.edu) |
| University of Iowa Iowa City, Iowa | Trisha Elliott - (trisha-elliott@uiowa.edu) |
| University of Kansas Medical Center Fairway, Kansas | Grace Millington - (gmillington@kumc.edu) |
| University of Nebraska Medical Center Omaha, Nebraska | Melissa Howard - (mehoward@unmc.edu) |
| Vanderbilt University Medical Center Nashville, Tennessee | Amanda Caroll - (Amanda.carroll@vumc.org) |
| Virginia Commonwealth University Henrico, Virginia | Esoterica Berry - (Esoterica.Berry@vcuhealth.org) |
| Virginia Mason Medical Center Seattle, Washington | Jin Yoon - (jin.yoon@commonspirit.org) |
| Wellstar Kennestone Hospital Marietta, Georgia | Jennifer Cuvo - (Jennifer.Cuvo@wellstar.org) |
| West Virginia University Morgantown, West Virginia | Danielle Walden - (danielle.walden@wvumedicine.org) |
Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)
ctrrecruit@vcu.edu
NCT06577441
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Inclusion Criteria:
* GENERAL MYLEOMATCH REGISTRATION CRITERIA:
* Patients must be registered to the Master Screening and Reassessment Protocol (MSRP) and assigned to this protocol by the MATCHBox Treatment Verification Team.
* Participants must not have received prior anti-cancer therapy for AML or MDS.
* Note: Hydroxyurea to control the white blood cell count (WBC) is allowed.
* Note: Prior erythroid stimulating agent (ESA) is not considered prior therapy for the purposes of eligibility.
* Participants must not be currently receiving any cytarabine-containing therapy other than up to 1 g/m\^2 of cytarabine, which is allowed for urgent cytoreduction. The use of prior hydroxyurea, all-trans retinoic acid (ATRA), BCR-ABL directed tyrosine kinase inhibitor, erythropoiesis-stimulating agent, thrombopoietin receptor agonist and lenalidomide is allowed
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients must have a morphologically-confirmed diagnosis of MDS with a Revised International Prognostic Scoring System (IPSS-R) score ≥ 4.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients must have a detectable pathogenic IDH2 mutation based on the National Cancer Institute (NCI) Myeloid Panel.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): No prior treatment with deoxyribonucleic acid (DNA) methyltransferase inhibitors (ASTX727, azacitidine, or decitabine).
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Prior treatment with growth factors (ESA, granulocyte colony-stimulating factor \[g-CSF\], thrombopoietin \[TPO\] agonist), lenalidomide or luspatercept is allowed with a maximum limit of 1 month of exposure.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients with therapy-related MDS are allowed.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Age ≥ 18 years.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Total bilirubin ≤ 1.5 x upper limit of normal (ULN)
* Unless elevated due to Gilbert's syndrome. In patients with Gilbert's syndrome, if the total bilirubin is ≤ 3.0 x ULN, then they are eligible for enrollment.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamic-pyruvic transaminase \[SGPT\]) ≤ 3.0 x upper limit of normal (ULN).
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Creatinine clearance ≥ 30 mL/min
* To be calculated using Cockroft Gault formula.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Not pregnant and not nursing, because this study involves: an agent that has known genotoxic, mutagenic and teratogenic effects.
* Therefore, for women of childbearing potential only, a negative pregnancy test done as part of screening lab work prior to registration is required.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible for this trial.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load.
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): Patients on the ASTX727 monotherapy arm (Regimen 1) that do not achieve a CR (complete response), CRL (CR with limited count recovery), or CRh (CR with partial count recovery) after completing 6 cycles of study treatment.
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): ECOG performance status ≤ 2.
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): Total bilirubin ≤ 1.5 x upper limit of normal (ULN).
* Unless elevated due to Gilbert's syndrome. In patients with Gilbert's syndrome if the total bilirubin is ≤ 3.0 x ULN, then they are eligible for enrollment.
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): AST (SGOT)/ALT (SGPT) ≤ 3.0 x upper limit of normal (ULN)
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): Creatinine clearance ≥ 30 mL/min
* To be calculated using Cockroft Gault formula.
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): Not pregnant and not nursing, because this study involves: an agent that has known genotoxic, mutagenic and teratogenic effects. PROCEDURE: Biospecimen Collection, PROCEDURE: Bone Marrow Aspiration, PROCEDURE: Bone Marrow Biopsy, DRUG: Decitabine and Cedazuridine, DRUG: Enasidenib
Myelodysplastic Syndrome
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Show 140 locations
Study Locations
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| Location | Contacts |
|---|---|
| Alta Bates Summit Medical Center-Herrick Campus Berkeley, California | |
| BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri | |
| Benefis Sletten Cancer Institute Great Falls, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Billings Clinic Cancer Center Billings, Montana | Site Public Contact - (research@billingsclinic.org) |
| Bozeman Health Deaconess Hospital Bozeman, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Cancer Care Center of O'Fallon O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Care Specialists of Illinois - Decatur Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Hematology Centers - Flint Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Carle Cancer Center Urbana, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Effingham Effingham, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | Site Public Contact - (Research@carle.com) |
| Carle at The Riverfront Danville, Illinois | Site Public Contact - (Research@Carle.com) |
| Centro Comprensivo de Cancer de UPR San Juan, | Site Public Contact - (ctsucontact@westat.com) |
| Community Hospital of Anaconda Anaconda, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Community Medical Center Missoula, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Community Medical Center Missoula, Montana | Site Public Contact - (Lennette.Gonzales@rwjbh.org) |
| Crossroads Cancer Center Effingham, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Decatur Memorial Hospital Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Duke University Medical Center Durham, North Carolina | |
| Duluth Clinic Ashland Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| East Carolina University Greenville, North Carolina | Site Public Contact - (eubankss@ecu.edu) |
| Essentia Health - Deer River Clinic Deer River, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center-South University Clinic Fargo, North Dakota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Hibbing Clinic Hibbing, Minnesota | |
| Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Sandstone Sandstone, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Virginia Clinic Virginia, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Geisinger Medical Center Danville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Genesee Hematology Oncology PC Flint, Michigan | |
| Genesys Hurley Cancer Institute Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Gundersen Lutheran Medical Center La Crosse, Wisconsin | Site Public Contact - (cancerctr@gundersenhealth.org) |
| HSHS Saint Elizabeth's Hospital O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Hennepin County Medical Center Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Huntsman Cancer Institute/University of Utah Salt Lake City, Utah | Site Public Contact - (cancerinfo@hci.utah.edu) |
| Illinois CancerCare - Washington Washington, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Bloomington Bloomington, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Canton Canton, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Carthage Carthage, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Dixon Dixon, Illinois | |
| Illinois CancerCare-Eureka Eureka, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Galesburg Galesburg, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Kewanee Clinic Kewanee, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Macomb Macomb, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Ottawa Clinic Ottawa, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Pekin Pekin, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peoria Peoria, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peru Peru, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Princeton Princeton, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Iowa Methodist Medical Center Des Moines, Iowa | |
| Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| LSU Health Baton Rouge-North Clinic Baton Rouge, Louisiana | Site Public Contact - (research@ololrmc.com) |
| Logan Health Medical Center Kalispell, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Loyola University Medical Center Maywood, Illinois | |
| Marshfield Medical Center - Weston Weston, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Medical College of Wisconsin Milwaukee, Wisconsin | |
| Memorial Hospital West Pembroke Pines, Florida | |
| Mercy Medical Center - Des Moines Des Moines, Iowa | |
| Miami Cancer Institute Miami, Florida | |
| Mills Health Center San Mateo, California | Site Public Contact - (clinicalresearch@sutterhealth.org) |
| Missouri Baptist Medical Center St Louis, Missouri | |
| Missouri Baptist Sullivan Hospital Sullivan, Missouri | |
| Monmouth Medical Center Long Branch, New Jersey | Site Public Contact - (mary.danish@rwjbh.org) |
| NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois | |
| NorthShore University HealthSystem-Glenbrook Hospital Glenview, Illinois | |
| NorthShore University HealthSystem-Highland Park Hospital Highland Park, Illinois | |
| Northwestern Medicine Cancer Center Delnor Geneva, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Cancer Center Kishwaukee DeKalb, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Glenview Outpatient Center Glenview, Illinois | |
| Northwestern Medicine Grayslake Outpatient Center Grayslake, Illinois | |
| Northwestern Medicine Lake Forest Hospital Lake Forest, Illinois | Site Public Contact - (cancertrials@northwestern.edu) |
| Northwestern Medicine Orland Park Orland Park, Illinois | Site Public Contact - (nctnprogram_rhlccc@northwestern.edu) |
| Northwestern University Chicago, Illinois | Site Public Contact - (cancer@northwestern.edu) |
| Ohio State University Comprehensive Cancer Center Columbus, Ohio | Site Public Contact - (Jamesline@osumc.edu) |
| Our Lady of The Lake Baton Rouge, Louisiana | |
| Our Lady of the Lake Physician Group Baton Rouge, Louisiana | Site Public Contact - (research@ololrmc.com) |
| Parkland Health Center - Farmington Farmington, Missouri | |
| Phoebe Putney Memorial Hospital Albany, Georgia | Site Public Contact - (ga_cares@augusta.edu) |
| Prisma Health Cancer Institute - Butternut Greenville, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Easley Easley, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Eastside Greenville, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Faris Greenville, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Greer Greer, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Seneca Seneca, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Roswell Park Cancer Institute Buffalo, New York | Site Public Contact - (askroswell@roswellpark.org) |
| Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey | |
| Saint Alphonsus Cancer Care Center-Nampa Nampa, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Saint Barnabas Medical Center Livingston, New Jersey | Site Public Contact - (joanne.loeb@rwjbh.org) |
| Saint Luke's Cancer Institute - Boise Boise, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Fruitland Fruitland, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Meridian Meridian, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Nampa Nampa, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin | Site Public Contact - (WI_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri | |
| San Juan City Hospital San Juan, | |
| Southern Illinois University School of Medicine Springfield, Illinois | |
| Springfield Clinic Springfield, Illinois | |
| Springfield Memorial Hospital Springfield, Illinois | Site Public Contact - (pallante.beth@mhsil.com) |
| Stony Brook University Medical Center Stony Brook, New York | |
| Swedish Cancer Institute-Edmonds Edmonds, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Swedish Cancer Institute-Issaquah Issaquah, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Swedish Covenant Hospital Chicago, Illinois | |
| Swedish Medical Center-First Hill Seattle, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| The James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky | |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology - Canton Canton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Tufts Medical Center Boston, Massachusetts | Site Public Contact - (ContactUsCancerCenter@TuftsMedicalCenter.org) |
| UC Comprehensive Cancer Center at Silver Cross New Lenox, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California | Site Public Contact - (ucstudy@uci.edu) |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine, California | Site Public Contact - (ucstudy@uci.edu) |
| UChicago Medicine Northwest Indiana Crown Point, Indiana | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| UF Health Cancer Institute - Gainesville Gainesville, Florida | |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny, Iowa | |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines, Iowa | |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines, Iowa | |
| UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee, Iowa | |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa | |
| UI Healthcare Mission Cancer and Blood - Pella Pella, Iowa | Site Public Contact - (trials@missioncancer.com) |
| University of Chicago Comprehensive Cancer Center Chicago, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| University of Chicago Medicine-Orland Park Orland Park, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa | |
| University of New Mexico Cancer Center Albuquerque, New Mexico | Site Public Contact - (HSC-ClinicalTrialInfo@salud.unm.edu) |
| University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma | Site Public Contact - (ou-clinical-trials@ouhsc.edu) |
| University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania | |
| University of Tennessee - Knoxville Knoxville, Tennessee | |
| UofL Health Medical Center Northeast Louisville, Kentucky | Site Public Contact - (ctoinfo@louisville.edu) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| Walter Reed National Military Medical Center Bethesda, Maryland | |
| William S Middleton VA Medical Center Madison, Wisconsin |
Vitamin D for Prostate Endocrine Therapy (ViPER)
Brooke Burgess, MS - URCC_22053@urmc.rochester.edu
NCT05838716
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Inclusion Criteria:
* Be diagnosed with Stage I-IV prostate cancer without metastases to bone (lymph node involvement and prior diagnosis of a primary cancer is allowed)
* Be age 50 years or older
* Be starting ADT or have received their first ADT treatment in the past 6 months, with a total of at least 6 planned months of treatment (both luteinizing hormone-releasing hormone \[LHRH\] antagonists and LHRH agonists are permitted)
* Have a total serum vitamin D between 10 and 32 ng/ml
* Have a total serum calcium of less than or equal to 10.5 mg/dl
* Have a normal GFR (glomerular filtration rate \> 30ml)
* Agree not to take calcium and/or vitamin D supplements for the duration of the intervention other than those provided by the study
* Be able to provide written informed consent
* Be able to swallow pills and capsules
* Be able to speak and read English
Exclusion Criteria:
* Have long term (greater than 3 months) use of any pharmacologic bone-modifying agent including but not limited to oral or intravenous (IV) bisphosphonates, denosumab, or teriparatide prior to enrollment
* Have a diagnosis of stage IV chronic kidney disease
* Have a diagnosis of grade II or greater hypercalcemia (serum calcium greater than 11.5 mg/dl)
* Have a history of hypercalcemia or vitamin D toxicity/sensitivity PROCEDURE: Biospecimen Collection, DIETARY_SUPPLEMENT: D Vitamin, PROCEDURE: Dual X-ray Absorptiometry, DRUG: Placebo Administration, OTHER: Quality-of-Life Assessment, OTHER: Questionnaire Administration
Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
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Show 51 locations
Study Locations
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| Location | Contacts |
|---|---|
| Adena Regional Medical Center Chillicothe, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Ballad Health Cancer Care - Bristol Bristol, Virginia | Site Public Contact - (charles.mays@balladhealth.org) |
| Ballad Health Cancer Care - Kingsport Kingsport, Tennessee | Site Public Contact - (charles.mays@balladhealth.org) |
| Bon Secours Cancer Institute at Reynolds Crossing Richmond, Virginia | Site Public Contact - (Anne_caramella@bshsi.org) |
| Bon Secours Memorial Regional Medical Center Mechanicsville, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Saint Francis Medical Center Midlothian, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Saint Mary's Hospital Richmond, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Cancer Care Center of O'Fallon O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Care Specialists of Illinois - Decatur Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Carilion Roanoke Memorial Hospital Roanoke, Virginia | |
| Carle Cancer Center Urbana, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Effingham Effingham, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | Site Public Contact - (Research@carle.com) |
| Carle at The Riverfront Danville, Illinois | Site Public Contact - (Research@Carle.com) |
| CarolinaEast Medical Center New Bern, North Carolina | Site Public Contact - (lharrison@carolinaeasthealth.com) |
| Community Medical Center Missoula, Montana | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Cancer Center Dickson City Dickson City, Pennsylvania | Site Public Contact - (hemoncctrials@geisinger.edu) |
| Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Gibbs Cancer Center-Gaffney Gaffney, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Gibbs Cancer Center-Pelham Greer, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Gundersen Lutheran Medical Center La Crosse, Wisconsin | Site Public Contact - (cancerctr@gundersenhealth.org) |
| Helen F Graham Cancer Center Newark, Delaware | Site Public Contact - (lbarone@christianacare.org) |
| Louisiana State University Health Science Center New Orleans, Louisiana | Site Public Contact - (emede1@lsuhsc.edu) |
| Medical Oncology Hematology Consultants PA Newark, Delaware | Site Public Contact - (lbarone@christianacare.org) |
| Mercy Hospital Coon Rapids, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mercy Hospital Saint Louis St Louis, Missouri | |
| Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Nash UNC HealthCare Rocky Mount, North Carolina | |
| Ochsner Medical Center Jefferson New Orleans, Louisiana | Site Public Contact - (Elisemarie.curry@ochsner.org) |
| OptumCare Cancer Care at Charleston Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Regional Cancer Center at Johnson City Medical Center Johnson City, Tennessee | Site Public Contact - (charles.mays@balladhealth.org) |
| Regions Hospital Saint Paul, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Ridgeview Medical Center Waconia, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| SMC Center for Hematology Oncology Union Union, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Saint Francis Cancer Center Greenville, South Carolina | Site Public Contact - (Heather_Rich@bshsi.org) |
| Saint Francis Hospital Greenville, South Carolina | Site Public Contact - (Heather_Rich@bshsi.org) |
| Saint John's Hospital - Healtheast Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin | Site Public Contact - (WI_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Spartanburg Medical Center Spartanburg, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| University Medical Center New Orleans New Orleans, Louisiana | Site Public Contact - (emede1@lsuhsc.edu) |
| University of Kansas Cancer Center Kansas City, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center - Lee's Summit Lee's Summit, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center - North Kansas City, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center-Overland Park Overland Park, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Health System Saint Francis Campus Topeka, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| VCU Massey Cancer Center at Stony Point Richmond, Virginia | Site Public Contact - (ctoclinops@vcu.edu) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
A Virtual Reality Brief Violence Intervention: Preventing Gun Violence Among Violently Injured Adults
Nicholas Thomson - Nicholas.thomson@vcuhealth.org
NCT06239285
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Inclusion Criteria:
* violently injured patients from VCU's Level 1 Trauma Center
* 18 years or older
* English-speaking
Exclusion Criteria:
* Under 18 years old
* Not a victim of Violent crime DEVICE: Brief Violence Intervention VR (BVI-VR), OTHER: Treatment as Usual (TAU)
Violence
Firearm Violence Victim
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Study Locations
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| Location | Contacts |
|---|---|
| Virginia Commonwealth University Henrico, Virginia | Nicholas Thomson - (nicholas.thomson@vcuhealth.org) |
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2) (SOHO-02)
Bayer Clinical Trials Contact - clinical-trials-contact@bayer.com
NCT06452277
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Inclusion Criteria:
* Participant must be ≥18 years of age or over the legal age of consent in countries where that is greater than 18 years at the time of signing the informed consent.
* Documented histologically or cytologically confirmed locally advanced non-squamous NSCLC, not suitable for definitive therapy or metastatic non-squamous NSCLC at screening (small cell or mixed histologies are excluded) (Stage III-IV NSCLC).
* Documented activating HER2 mutation in the tyrosine kinase domain (TKD) assessed by tissue molecular test in a CLIA-certified (US sites) or an equally accredited (outside of the US) local laboratory. However, participants may be included at the discretion of the investigator if the laboratory performing the assay is not CLIA or similar certified but the laboratory is locally accredited.
* No prior systemic therapy for locally advanced or metastatic disease. No prior treatment with a HER2 ex20ins-targeted therapy (e.g. poziotinib, trastuzumab deruxtecan). Participants who received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant therapy was completed at least 12 months prior to the start of screening.
* Eligible to receive treatment with the selected platinum-based doublet-chemotherapy (i.e. cisplatin/pemetrexed or carboplatin/pemetrexed) and pembrolizumab in accordance with the SmPC/Product Information.
Exclusion Criteria:
* Known history of prior malignancy except if the participant has undergone potentially curative therapy with no evidence of that disease recurrence for five years since initiation of that therapy. Exception: the following cancer types are acceptable within five years if curatively treated or under surveillance:
* a. in situ cancers of cervix, breast, or skin,
* b. superficial bladder cancer (Ta, Tis and T1),
* c. limited-stage prostate cancer,
* d. basal or squamous cancers of the skin.
* Tumors with targetable alterations with approved available therapy, with the exception of HER2 mutation in the TKD.
* Inability to discontinue treatment with chronic systemic corticosteroids. Participants who require intermittent use of bronchodilators, inhaled steroids, or local steroid injections would not be excluded from the study. Replacement therapy (e.g., physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is acceptable, provided that the dose is stable for \>4 weeks prior to planned start of study intervention.
* Pre-existing peripheral neuropathy that is Grade ≥2 by CTCAE (v5.0).
* History of severe hypersensitivity reaction to treatment with a monoclonal antibody.
* Prior radiotherapy outside of the brain within 21 days before of planned start of study intervention. Participants must have recovered from all radiation-related toxicities and not require corticosteroids. DRUG: Sevabertinib, DRUG: Pembrolizumab, DRUG: Cisplatin, DRUG: Carboplatin, DRUG: Pemetrexed
Advanced Non-small Cell Lung Cancer, HER2 Mutation
NSCLC, ERBB2 mutation, HER2 mutation
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Show 284 locations
Study Locations
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| Location | Contacts |
|---|---|
| ?enry Dunant Hospital Center-4th Oncology Department and Clinical Trials Unit Athens, | |
| A Beneficencia Portuguesa de Sao Paulo - Hospital BP Mirante São Paulo, São Paulo | |
| AORN San Giuseppe Moscati Avellino - U.O.C. Oncologia Medica Avellino, Campania | |
| ASST Sette Laghi_Ospedale Macchi - Oncologia Varese, | |
| AZ Delta | Clinical Trial Center - Pneumology Roeselare, West-Flanders | |
| Aalborg University hospital - oncology department Aalborg, North Denmark | |
| Aarhus Universitetshospital Aarhus, | |
| Adana Sehir Egitim ve Arastirma Hastanesi Yüreğir, Adana | |
| AdventHealth Cancer Institute Orlando Orlando, Florida | |
| Allegheny General Hospital Pittsburgh, Pennsylvania | |
| Ankara Bilkent Sehir Hastanesi Ankara, | |
| Ankara Etlik Sehir Hastanesi Yenimahalle, Ankara | |
| Antwerp University Hospital | Oncology Department Antwerp, | |
| Assuta Ashdod Public Hospital (R.A) Ashdod, | |
| Austin Hospital - Olivia Newton John Cancer Research Institute Heidelberg, Victoria | |
| Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Oncologia Medica Palermo, | |
| Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - UOC Oncologia Medica Bologna, Emilia-Romagna | |
| Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica Orbassano, Piedmont | |
| BC Cancer | Vancouver Vancouver, British Columbia | |
| Beacon Hospital Petaling Jaya, Selangor | |
| Beijing Cancer Hospital - Oncology Department Beijing, Beijing Municipality | |
| Beijing Chest Hospital, Capital Medical University Beijing, | |
| Beijing Hospital Beijing, Beijing Municipality | |
| Belfast City Hospital Belfast, | |
| Brampton Civic Hospital | Oncology Brampton, Ontario | |
| Budapesti Uzsoki Utcai Korhaz - Tüdogyógyászati Osztály Budapest, | |
| CHU Montpellier - Hopital Arnaud de Villeneuve - Service oncologie thoracique Montpellier, Occitanie | |
| CHU de Rouen - Hopital Charles Nicolle - Service de Pneumologie Rouen, Normandy | |
| CHULN - Hospital Pulido Valente Lisbon, | |
| Calvary Mater Hospital Newcastle - Oncology Waratah, New South Wales | |
| Cancer Hospital, Chinese Academy of Medical Sciences Beijing, | |
| CardioMed S.R.L. Cluj-Napoca, | |
| Careggi University Hospital - Oncologia Clinica Florence, | |
| Careggi University Hospital - Oncologia Clinica Florence, | |
| Centre Antoine Lacassagne - Departement Oncologie Nice, Provence-Alpes-Côte d'Azur Region | |
| Centre Hospitalier Intercommunal Creteil - Service de pneumologie Créteil, Île-de-France Region | |
| Centre Hospitalier Michallon Grenoble - Service pneumologie La Tronche, Auvergne-Rhône-Alpes | |
| Centre Hospitalier Universitaire de Limoges - unite oncologie thoracique Limoges, New Aquitaine | |
| Centro Médico Privado CEMAIC Córdoba, | |
| Centro Paulista de Oncologia (CPO) - Sao Paulo - Faria Lima Brasília, Federal District | |
| Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia Verona, | |
| Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC) Buenos Aires, | |
| Centro de Investigaciones Clínicas, Clínica Viedma Viedma, | |
| Centro de Pesquisa da Clínica de Oncologia Reichow Blumenau, Santa Catarina | |
| Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati Aviano, Friuli Venezia Giulia | |
| Centrul de Oncologie Sfantul Nectarie Craiova, | |
| Charité Universitätsmedizin Berlin CBF - Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie Berlin, | |
| Chi-Mei Medical Center, Liouyine Tainan, | |
| Chonnam National University Hwasun Hospital | Pulmonology and Critical Care Medicine Hwasun Gun, Jeollanam-do | |
| Chung Shan Medical University Hospital Taichung, | |
| Chungbuk National University Hospital Cheongju-si, | |
| Clinica Integral Internacional de Oncologia S. de R.L. de C.V. Puebla City, | |
| Columbia Asia Hospital Bukit Rimau Shah Alam, Selangor | |
| Complex Oncology Center - Plovdiv EOOD Plovdiv, Plovdiv Province | |
| Complexo Hospitalario Universitario A Coruna | Oncologia A Coruña, | |
| Concord Repatriation General Hospital - Medical Oncology Clinical Trials Unit Concord, New South Wales | |
| Curie Oncology | Farrer Singapore, | |
| Docrates Mehiläinen Syöpäsairaala Helsinki, Uusimaa | |
| Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii Wroclaw, | |
| Ege Universitesi Tip Fakultesi Hastanesi Izmir, Bornova | |
| Fakultna Nemocnica Trnava Trnava, Trnava Region | |
| Fakultní Nemocnice Olomouc - Klinika plicních nemocí a tuberkulózy Olomouc, | |
| Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1 Milan, Lombardy | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOSD Oncologia Toraco-Polmonare Rome, Lazio | |
| Fujian Cancer Hospital Fuzhou, | |
| Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica Lisbon, | |
| Fundacion Instituto Valenciano De Oncologia | Oncologia Valencia, | |
| Fundación CENIT para la Investigación en Neurociencias CABA, Ciudad Auton. de Buenos Aires | |
| Fundação Pio XII - Hospital de Câncer de Barretos Barretos, | |
| General Hospital of Athens "Alexandra''-Plasma Cell Dyscrasias,Department of Clinical Therapeutics,School of Medicine,NKUA Athens, | |
| General University Hospital Of Larissa-Department of Medical Oncology Larissa, | |
| Genesis Hospital- Department of Pathological Oncology Pylaia Thessaloniki, Thessaloniki | |
| Geniko Nosokomeio Thessalonikis George Papanikolaou-Pulmonary Department Thessaloniki, | |
| Gleneagles Penang Medical Center George Town, Pulau Pinang | |
| Guangxi Medical University (GXMU) - Affiliated Tumor Hospital Nanning, | |
| Gustave Roussy - Departement Oncologie-Radiotherapie Villejuif, Île-de-France Region | |
| Gyeongsang National University Hospital Jinju, Gyeongsangnam-do | |
| HFR Freiburg - Kantonsspital Fribourg, | |
| Harbin Medical University Cancer Hospital Harbin, | |
| Hokkaido University Hospital Sapporo, | |
| Hong Kong United Oncology Centre Kowloon, | |
| Hopital Foch - Oncologie digestive et thoracique Suresnes, Île-de-France Region | |
| Hopital La Cavale Blanche - CHU de Brest - institut de cancerologie et d'imagerie Brest, Brittany Region | |
| Hopital Nord Laennec - Oncologie medicale thoracique et digestive Nantes, Pays de la Loire Region | |
| Hospital Clinic De Barcelona | Oncologia Barcelona, | |
| Hospital General Universitario Gregorio Marañón | Oncología Madrid, | |
| Hospital Germans Trias I Pujol | Oncologia Badalona, Barcelona | |
| Hospital Pedro Hispano | Clinical Research Center Matosinhos Municipality, Porto District | |
| Hospital Sirio Libanes São Paulo, | |
| Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia São Paulo, São Paulo | |
| Hospital Universitari Dexeus Grupo Quironsalud | Oncologia Barcelona, | |
| Hospital Universitari Vall D Hebron | Oncologia Barcelona, | |
| Hospital Universitario De Navarra | Oncologia Pamplona, Navarre | |
| Hospital Universitario Fundacion Jimenez Diaz | Oncologia Madrid, | |
| Hospital Universitario Puerta De Hierro De Majadahonda | Oncologia Majadahonda, Madrid | |
| Hospital Universitario Ramon Y Cajal | Oncologia Madrid, | |
| Hospital Universitario Y Politecnico La Fe | Oncologia Valencia, | |
| Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia Monterrey, | |
| Hospital de Base | Funfarme - Centro Integrado de Pesquisa - Cardiologia São José do Rio Preto, São Paulo | |
| Hubei Cancer Hospital Wuhan, | |
| Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia Rozzano, Lombardy | |
| Hunan Cancer Hospital - Oncology Department Changsha, Hunan | |
| I.A.Ü. VM Medical Park Florya Hastanesi Küçükçekmece, Istanbul | |
| I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena -- Oncologia Medica 2 Rome, Lazio | |
| IPO Porto Porto, | |
| Institut Bergonié - Unicancer Nouvelle Aquitaine Bordeaux, New Aquitaine | |
| Institut Coeur Poumon CHRU Lille - Pole Cardio-vasculaire et pulmonaire Lille, Hauts-de-France | |
| Institut Curie - Paris - Oncologie medicale Paris, Île-de-France Region | |
| Institut de Cancerologie Ouest - Saint-Herblain Saint-Herblain, Pays de la Loire Region | |
| Instituto Argentino de Diagnostico y Tratamiento (IADT) TBC, | |
| Instituto Nacional De Cancerologia Bogotá, | |
| Institutul Oncologic Prof. Dr. Alexandru Trestioreanu (IOB); Oncologie Medicala II Bucharest, | |
| Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca, | |
| Instytut Gruzlicy i Chorob Pluc Warsaw, | |
| Irmandade Santa Casa de Misericordia de Porto Alegre | Oncology São Paulo, São Paulo | |
| Istanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçin Sehir Hastanesi Kadıköy, Istanbul | |
| Istituto Europeo di Oncologia s.r.l - Oncologia Toracica Milan, Lombardy | |
| Istituto Oncologico Veneto_Padova - UOC Oncologia 2 Padova, Veneto | |
| Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. - GDP Toracica Meldola, Emilia-Romagna | |
| Jewish General Hospital | Pulmonary Oncology Montreal, Quebec | |
| Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University Nanjing, | |
| Jilin Cancer Hospital Changchun, Jilin | |
| John B. Amos Cancer Center Columbus, Georgia | |
| Kansai Medical University Hospital Hirakata, | |
| Kantonsspital Baden Baden, | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung City, | |
| Kindai University Hospital Sakai, Osaka | |
| Kitasato University Hospital Sagamihara, Kanagawa | |
| Klinik Floridsdorf, Pneumo-onkologische Ambulanz und Tagesklinik Vienna, | |
| Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik Cologne, North Rhine-Westphalia | |
| Klinikum Nürnberg - Klinik für Innere Medizin 3, Schwerpunkt Pneumologie (Lungenheilkunde) Nuremberg, | |
| Kobe University Hospital Hyogo, Kobe, | |
| Komarom-Esztergom Varmegyei Szent Borbala Korhaz Tatabánya, | |
| Krajská nemocnice T. Bati - Pneumoonkologická a klinická onkologie Zlín, Zlín | |
| Kyiv City Clinical Oncology Center - Department of Chemotherapy #1 Kyiv, | |
| LLC "RDP Ukraine" - Medical Department Dnipro, | |
| Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica Natal, Rio Grande do Norte | |
| Limited Liability Company "MedOffice Group Medical Center" Kyiv, | |
| LinYi Cancer Hospital (Linyi Tumor Hospital) Linyi, | |
| Lungenklinik Hemer, Thorakale Onkologie und onkologische Palliativmedizin Hemer, | |
| M Health Fairview Masonic Cancer Clinic - Clinics and Surgery Center Minneapolis, Minnesota | |
| MHAT "Heart and brain" Pleven Pleven, Pleven Province | |
| MHAT Park Hospital EOOD Plovdiv, Plovdiv Province | |
| MHAT Serdika Sofia, Sofia City Province | |
| MHAT Sveta Marina EAD Varna, Varna Province | |
| MHAT Uni Hospital Panagyurishte, Pazardzhik Province | |
| MNCE "Uzhhorod City Multidisciplinary Clinical Hospital" -Oncology Department Uzhhorod, | |
| Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi Istanbul, | |
| Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP) Brno, | |
| Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy w Otwocku Otwock, | |
| Medical Center LLC "Verum Expert Clinic" Kyiv, | |
| Medizinische Universität Wien Universitätsklinik f. Innere Medizin I Klinische Abteilung für Onkologie Vienna, State of Vienna | |
| Memorial Cancer Institute at Miramar Miramar, Florida | |
| Metropolitan Hospital- 4th Oncology Clinic Piraeus, | |
| Moffitt Cancer Center Tampa, Florida | |
| Moffitt Cancer Center - Magnolia Campus Tampa, Florida | |
| Multiprofile Hospital for Active Treatment "Sveta Sofia" Sofia, Sofia City Province | |
| Municipal Enterprise Rivne Regional Antitumor Center of the Rivne Regional Council, Abdominal department Rivne, | |
| NAIC - Instituto do Cancer Bauru, São Paulo | |
| NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School Nanjing, Jiangsu | |
| NSW Health - Blacktown Hospital Blacktown, New South Wales | |
| Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej Warsaw, Masovian Voivodeship | |
| Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej Warsaw, Masovian Voivodeship | |
| National Cancer Center Hospital East Kashiwa, | |
| National Cancer Center Singapore - Oncology Department Singapore, | |
| National Cheng Kung University Hospital Tainan, | |
| National Hospital Organization Himeji Medical Center Himeji, | |
| National Hospital Organization Kyushu Medical Center Fukuoka, | |
| National Hospital Organization Nagoya Medical Center Nagoya, | |
| National Hospital Organization-Yamaguchi-Ube Medical Center (Sanyo Hospital) Ube, Yamaguchi | |
| National Taiwan University Hospital Taipei, | |
| National Taiwan University Hospital (NTUH) - Cancer Research Center Taipei, | |
| Nederlands Kanker Instituut Amsterdam, North Holland | |
| Nemocnice AGEL Nový Jicín a.s. - Oddelení radioterapie a onkologie Nový Jicín, | |
| Nemocnice AGEL Ostrava-Vítkovice a. s. - Plicní oddelení Ostrava - Vítkovice, | |
| Niigata Cancer Center Hospital Niigata, | |
| Nippon Medical School - Nippon Medical School Hospital - Cancer Center Bunkyo-ku, Tokyo | |
| Norrlands Universitetssjukhus Umeå - Cancercentrum Umeå, Västerbotten County | |
| ONCARE Treatment Center San Pedro Garza García, | |
| Odense University Hospital - Oncology Department Odense, Region Syddanmark | |
| Oncare Viaducto Nápoles Mexico City, | |
| OncoCare Cancer Centre | Gleneagles Medical Centre Singapore, | |
| Oncocenter Timișoara, | |
| Oncologia Integral Satelite Naucalpan, | |
| Osaka International Cancer Institute Osaka, | |
| Ospedale San Raffaele s.r.l. - Oncologia Medica Milan, | |
| Ospedale Vito Fazzi Lecce - Oncologia Lecce, | |
| POKO Poprad s.r.o. Poprad, | |
| Patty & George Hoag Cancer Center Newport Beach, California | |
| Piedmont Healthcare - Atlanta Atlanta, Georgia | |
| Prince of Wales Hospital Shatin, New Territories | |
| Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology Toronto, Ontario | |
| Private Enterprise Private Production Company "Acinus", Treatment and Diagnostic Center Kropyvnytskyi, | |
| Profound Research - OMG - Royal Oak Cancer Center Royal Oak, Michigan | |
| Profound Research -OMG - TriAtria Cancer Center Farmington Hills, Michigan | |
| Pronutrir Fortaleza - CE Fortaleza, Ceará | |
| Providence Cancer Institute - Franz Clinic Portland, Oregon | |
| Providence Oncology and Hematology Care Clinic Westside Portland, Oregon | |
| Pusan National University Yangsan Hospital Yangsan, | |
| Queen Elizabeth Hospital Hong Kong Hong Kong, Hong Kong SAR | |
| Queen Mary Hospital Hong Kong, | |
| R.J. Zuckerberg Cancer Center New Hyde Park, New York | |
| Radboud University Medical Center | Afdeling Interne Geneeskunde Nijmegen, Gelderland | |
| Radiotherapy Center Cluj SRL Flore?ti, Comuna Floresti | |
| Raffles Cancer Centre Singapore, | |
| Rede DoR Recife - PE Recife, Pernambuco | |
| Regional Medical Oncology Centre_Oncology Chemotherapy Department Lutsk, | |
| Regionshospitalet Gødstrup - Medicinsk afdeling Herning, Central Jutland | |
| Rigshospitalet - Kræftbehandling Copenhagen, Capital Region | |
| Robert Bosch Krankenhaus - Haematologie, Onkologie und Palliativmedizin Stuttgart, | |
| Royal Surrey County Hospital Guildford, Surrey | |
| S.C Ovidius Clinical Hospital SRL - Oncology Department Ovidiu, | |
| Saitama Cancer Center Kitaadachi-gun, | |
| Sakarya Universitesi Egitim ve Arastirma Hastanesi Sakarya, | |
| Samsung Medical Center - Oncology Department Seoul, | |
| Sc Oncolab Srl Craiova, Dolj | |
| Sendai Kousei Hospital Miyagi, | |
| Seoul National University Hospital Seoul, Seoul Teugbyeolsi | |
| Severance Hospital, Yonsei University Health System - Oncology Department Seoul, Seoul Teugbyeolsi | |
| Shaare Zedek Medical Center (SZMC) Jerusalem, | |
| Shandong University - Shandong Cancer Hospital Jinan, | |
| Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai, Shanghai Municipality | |
| Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department Hangzhou, Zhejiang | |
| Skånes Universitetssjukhus - Lund - STROKE UNIT? Lund, Skåne County | |
| Soroka Medical Center- Legacy Heritage Cancer Center Beersheba, | |
| Specialized Hospital for Active Treatment of Oncology Sofia, Sofia City Province | |
| Spitalul Clinic Coltea Bucharest, | |
| St.Vincent's Hospital - Oncology Department Suwon, | |
| Sunway Medical Centre Subang Jaya, | |
| Sunway Medical Centre Penang Perai, Pulau Pinang | |
| Swietokrzyskie Centrum Onkologii Kielce, | |
| Taichung Veterans General Hospital Taichung, | |
| Taipei Veterans General Hospital Taipei, | |
| Tan Tock Seng Hospital Singapore, | |
| Taylor Cancer Research Center Maumee, Ohio | |
| Tel-Aviv Sourasky Medical Center Tel Aviv, | |
| The Canberra Hospital (TCH) - Canberra Region Cancer Centre (CRCC) Garran, | |
| The First Affiliated Hospital of Guangzhou Medical University Guangzhou, | |
| The Oncology Institute of Hope and Innovation - Fort Lauderdale 17th Street Fort Lauderdale, Florida | |
| The People's Liberation Army General Hospital (Beijing 301 Hospital) Beijing, | |
| The University of Chicago Medical Center - Hyde Park - Hematology & Oncology Chicago, Illinois | |
| The University of Texas MD Anderson Cancer Center - Texas Medical Center Houston, Texas | |
| Thoracic General Hospital Of Athens I Sotiria-3rd University Department of Internal Medicine Athens, | |
| Toowoomba Hospital Oncology Clinical Trials Toowoomba, Queensland | |
| Torbay Hospital Torquay, | |
| Tottori University Hospital Yonago, | |
| Turku University Hospital, Turun yliopistollinen sairaala (TYKS) - Keuhkosairauksien poliklinikka Turku, Southwest Finland | |
| UC Medical Center - Oncology Cincinnati, Ohio | |
| UC San Diego Health - Moores Cancer Center San Diego, California | |
| UCLA Health Santa Monica Cancer Care Santa Monica, California | |
| UCSF Bakar Precision Cancer Medicine Building - Thoracic Surgery and Oncology San Francisco, California | |
| UM Greenebaum Comprehensive Cancer Center Baltimore, Maryland | |
| UMass Memorial Medical Center - University Campus - Hematology/Oncology Worcester, Massachusetts | |
| UZ Leuven Gasthuisberg - Pneumology Department Leuven, Vlaams-Brabant | |
| Unidade Local de Saúde de Coimbra, E.P.E. - Hospitais da Universidade de Coimbra - Serviço de Urologia Coimbra, | |
| Uniklinikum Salzburg, Universitätsklinik für Innere Medizin III Vienna, State of Salzburg | |
| Uniklinikum Salzburg, Universitätsklinik für Pneumologie/ Lungenheilkunde Vienna, State of Salzburg | |
| Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech Wuhan, Hubei | |
| Universitaetsklinikum Essen - Innere Klinik (Tumorforschung) Essen, North Rhine-Westphalia | |
| Universitaetsklinikum Giessen und Marburg - Medizinische Klinik IV Organonkologie Giessen, Hesse | |
| Universiti Malaya Medical Centre Kuala Lumpur, Kuala Lumpur | |
| University General Hospital Attikon, 2nd Department of Propaedeutic and Internal Medicine Athens, | |
| University General Hospital Attikon-4th Department of Internal Medicine Chaïdári, Attica | |
| University Hospital Kebangsaan Malaysia Cheras, Kuala Lumpur and Selangor | |
| University Hospital Simmons Cancer Center Lung/Head Neck Clinic Dallas, Texas | |
| University Multiprofile Hospital For Active Treatment Sofiamed OOD, Sofia Sofia, Sofia City Province | |
| University of Electronic Science & Technology of China - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital) Chengdu, | |
| University of Illinois Hospital - Outpatient Cancer Care Center Chicago, Illinois | |
| University of the Sunshine Coast Buderim, Queensland | |
| Universitätsklinikum Frankfurt - Medizinische Klinik II, Hämatologie und Onkologie Frankfurt, | |
| Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi Lodz, | |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Bialystok, | |
| VCU Health Ambulatory Care Center - Cardiology Richmond, Virginia | |
| Velindre University NHS Trust | Velindre Cancer Centre - Clinical Trials Unit Cardiff, Wales | |
| West China Hospital Sichuan University Chengdu, | |
| Wielkopolskie Centrum Pulmonologii i Torakochirurgii Poznan, | |
| Xiamen University - The First Affiliated Hospital Xiamen, | |
| Zhejiang Cancer Hospital Hangzhou, | |
| Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province Taizhou, Zhejiang | |
| Zhongshan Hospital, Fudan University Shanghai, | |
| hopital Emile Muller - Service Pneumologie Mulhouse, Grand Est | |
| hopital Lyon sud HCL - Pneumologie aigue specialisee et cancerologie thoracique Pierre-Bénite, Auvergne-Rhône-Alpes | |
| hopital cochin APHP - service de pneumologie Paris, Île-de-France Region | |
| hospital Italiano de Buenos Aires Ciudad Autonoma Buenos Aires, |
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
Toll Free Number - Trialsites@msd.com
NCT06136559
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Inclusion Criteria:
The main inclusion criteria include but are not limited to the following:
* Confirmed diagnosis of CLL/SLL and active disease clearly documented to have a need to initiate therapy.
* Has at least 1 marker of disease burden.
* Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 within 7 days before randomization.
* Has the ability to swallow and retain oral medication.
* Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks and have undetectable HBV deoxyribonucleic acid (DNA) viral load before randomization.
* Participants with history of hepatitis C virus (HCV) infection are eligible if HCV ribonucleic acid (RNA) viral load is undetectable at screening.
* Participants with human immunodeficiency virus (HIV) who meet ALL eligibility criteria.
Exclusion Criteria:
The main exclusion criteria include but are not limited to the following:
* Has an active hepatitis B virus/ hepatitis C virus (HBV/HCV) infection.
* Has gastrointestinal (GI) dysfunction that may affect drug absorption.
* Has diagnosis of Richter Transformation or active central nervous system (CNS) involvement by CLL/SLL.
* Has had acquired immune deficiency syndrome (AIDS)-defining opportunistic infection in the past 12 months before screening.
* Has clinically significant cardiovascular disease.
* Has hypersensitivity to nemtabrutinib or contraindication to ibrutinib or acalabrutinib, or any of the excipients.
* Has history of severe bleeding disorder.
* Has known additional malignancy that is progressing or has required active treatment within the past 2 years.
* Has received any systemic anticancer therapy for CLL/SLL.
* Is currently being treated with p-glycoprotein (P-gp) substrates with a narrow therapeutic index, cytochrome P450 3A (CYP3A) strong or moderate inducers or CYP3A strong inhibitors.
* Received prior radiotherapy within 2 weeks of start of study intervention, or radiation-related toxicities, requiring corticosteroids.
* Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines are allowed.
* Has received an investigational agent or has used an investigational device within 4 weeks before study intervention administration.
* Has active infection requiring systemic therapy, including intravenous (IV) antibiotics during screening.
* Participants who have not adequately recovered from major surgery or have ongoing surgical complications. DRUG: Nemtabrutinib, DRUG: Ibrutinib, DRUG: Acalabrutinib
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
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Show 198 locations
Study Locations
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| Location | Contacts |
|---|---|
| AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0205) Mechelen, Antwerpen | |
| Aalborg Universitetshospital, Syd ( Site 0403) Aalborg, North Denmark | |
| Akershus Universitetssykehus ( Site 0902) Lørenskog, Akershus | |
| Alta Bates Summit Medical Center ( Site 0004) Berkeley, California | |
| Anhui Provincial Cancer Hospital Clinical Trial Ethics Committee ( Site 2001) Hefei, Anhui | |
| Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1407) Ankara, | |
| Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 1401) Ankara, | |
| Antalya Egitim ve Arastırma Hastanesi ( Site 1409) Antalya, | |
| Aotearoa Clinical Trials ( Site 3201) Auckland, | |
| Arizona Oncology Associates - NAHOA ( Site 8007) Prescott, Arizona | |
| BC Cancer Kelowna ( Site 0112) Kelowna, British Columbia | |
| BC Cancer Victoria ( Site 0109) Victoria, British Columbia | |
| Banner MD Anderson Cancer Center ( Site 0059) Gilbert, Arizona | |
| Banner MD Anderson Cancer Center - University Medical Center Phoenix ( Site 0051) Phoenix, Arizona | |
| Barnet Hospital ( Site 3005) Barnet, | |
| Bnai Zion Medical Center ( Site 1505) Haifa, | |
| Bradfordhill-Clinical Area ( Site 2310) Santiago, Region M. de Santiago | |
| Cancer Care Associates Of York ( Site 0005) York, Pennsylvania | |
| Cancer Institute Hospital of JFCR ( Site 1906) Koto, Tokyo | |
| Care Access - South Pasadena ( Site 0070) Pasadena, California | |
| Carolina Oncology Specialists, PA ( Site 0054) Charlotte, North Carolina | |
| Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski ( Site 0100) Rimouski, Quebec | |
| Centro Medico Monte Carmelo-Oncology ( Site 2706) Arequipa, Ariqipa | |
| Centro de Infusion Superare ( Site 2602) Mexico City, Mexico City | |
| Champalimaud Foundation ( Site 3102) Lisbon, Lisbon District | |
| Chang Gung Medical Foundation-Linkou Branch ( Site 1703) Taoyuan, | |
| Chang Gung Memorial Hospital at Kaohsiung-Division of Hematology and Oncology ( Site 1702) Kaohsiung City, | |
| Chiba Cancer Center ( Site 1905) Chiba, | |
| Chongqing University Cancer Hospital ( Site 2041) Chongqing, Chongqing Municipality | |
| Chulalongkorn University ( Site 1802) Pathumwan, Bangkok | |
| City Hospital, Nottingham University Hospitals NHS Trust ( Site 3003) Nottingham, | |
| Clermont Oncology Center ( Site 0046) Clermont, Florida | |
| Clínica Alemana de Santiago-Unidad de Investigaciones ( Site 2306) Santiago, Region M. de Santiago | |
| Clínica Anglo Americana ( Site 2701) Lima, | |
| Constantiaberg Haematology ( Site 1106) Plumstead, Western Cape | |
| Consultants in Medical Oncology and Hematology (CMOH) ( Site 8002) Broomall, Pennsylvania | |
| Corewell Health-Lemmon Holton Cancer Pavilion ( Site 0011) Grand Rapids, Michigan | |
| Eastern CT Hematology & Oncology Associates ( Site 0033) Norwich, Connecticut | |
| Ege Universitesi Hastanesi ( Site 1404) Izmir, | |
| Ethics Committee of Union Hospital Tongji Medical College Huazhong University of Science and Technol ( Site 2015) Wuhan, Hubei | |
| Evangelismos General Hospital of Athens ( Site 0700) Athens, Attica | |
| FALP-UIDO ( Site 2300) Santiago, Region M. de Santiago | |
| Faculty of Medicine Siriraj Hospital-Division of Hematology, Department of Medicine ( Site 1801) Bangkok, Bangkok | |
| Fakultni nemocnice Hradec Kralove-IV. interni hematologicka klinika ( Site 0301) Hradec Králové, | |
| Fakultni nemocnice Olomouc ( Site 0303) Olomouc, | |
| Florida Cancer Specialists - East ( Site 7002) West Palm Beach, Florida | |
| Florida Cancer Specialists - South ( Site 7001) Fort Myers, Florida | |
| Fundacion Valle del Lili- CIC-Oncology CIC ( Site 2402) Cali, Valle del Cauca Department | |
| Galilee Medical Center ( Site 1507) Nahariya, | |
| General Hospital of Athens "Laiko" ( Site 0704) Athens, Attica | |
| GenesisCare - Bristol ( Site 3011) Bristol, South Gloucestershire | |
| GenesisCare - Cambridge ( Site 3001) Newmarket, Suffolk | |
| GenesisCare - Windsor ( Site 3002) Windsor, Windsor And Maidenhead | |
| Groote Schuur Hospital-Clinical Haematology ( Site 1100) Cape Town, Western Cape | |
| Grupo Médico ASSET ( Site 2611) Mexico City, | |
| Guangxi Medical University Affiliated Tumor Hospital ( Site 2004) Nanning, Guangxi | |
| Gunma University Hospital ( Site 1903) Maebashi, Gunma | |
| HOSPITAL CLÍNIC DE BARCELONA ( Site 1202) Barcelona, Catalonia | |
| HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 1208) Majadahonda, Madrid, Comunidad de | |
| HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1209) Pozuelo de Alarcón, Madrid | |
| Hadassah Medical Center-Hemato-Oncology ( Site 1500) Jerusalem, | |
| Haemalife ( Site 1105) Kuilsriver, Western Cape | |
| Hainan General Hospital ( Site 2018) Haikou, Hainan | |
| Health Pharma Professional Research S.A. de C.V: ( Site 2608) Mexico City, Mexico City | |
| Henan Cancer Hospital-hematology department ( Site 2025) Zhengzhou, Henan | |
| Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 1913) Hiroshima, | |
| Hokkaido University Hospital ( Site 1900) Sapporo, Hokkaido | |
| Hospital 9 De Julho ( Site 2206) São Paulo, São Paulo | |
| Hospital Paulistano-Americas Oncologia ( Site 2202) São Paulo, | |
| Hospital Pulau Pinang ( Site 1602) George Town, Pulau Pinang | |
| Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1206) Barcelona, | |
| Hospital Universitario de Salamanca - Complejo Asistencial U-Servicio de Hematologia ( Site 1201) Salamanca, | |
| Hunan Cancer Hospital ( Site 2020) Changsha, Hunan | |
| IMAT S.A.S ( Site 2401) Montería, Departamento de Córdoba | |
| InVO Institut für Versorgungsforschung in der Onkologie ( Site 0606) Koblenz, Rhineland-Palatinate | |
| Inova Schar Cancer Institute ( Site 0015) Fairfax, Virginia | |
| Institut Català d'Oncologia - L'Hospitalet-Haematology Department ( Site 1207) L'Hospitalet Del Llobregat, Barcelona | |
| Institute of hematology&blood disease hospital-Lymphoma ( Site 2005) Tianjin, Tianjin Municipality | |
| Instituto Nacional de Câncer - INCA ( Site 2201) Rio de Janeiro, | |
| Instituto Português de Oncologia de Lisboa Francisco Gentil ( Site 3103) Lisbon, Lisbon District | |
| Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 3100) Porto, | |
| Intermountain Health St. Mary's Regional Hospital ( Site 0025) Grand Junction, Colorado | |
| Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana ( Site 0052) Billings, Montana | |
| Japanese Red Cross Osaka Hospital ( Site 1908) Osaka, | |
| Jiangsu Province Hospital ( Site 2000) Nanjing, Jiangsu | |
| Jiangxi Provincial Cancer Hospital ( Site 2009) Nanchang, Jiangxi | |
| John Theurer Cancer Center at Hackensack University Medical Center ( Site 0016) Hackensack, New Jersey | |
| Karolinska Universitetssjukhuset Solna ( Site 1302) Stockholm, Stockholm County | |
| Kindai University Hospital ( Site 1909) Sakai, Osaka | |
| Kliniken Maria Hilf ( Site 0603) Mönchengladbach, North Rhine-Westphalia | |
| Kobe City Medical Center General Hospital ( Site 1910) Kobe, Hyōgo | |
| Kyushu University Hospital ( Site 1914) Fukuoka, | |
| Liuzhou People's Hospital ( Site 2029) Liuzhou, Guangxi | |
| Lutheran Medical Center ( Site 0027) Golden, Colorado | |
| Maharaj Nakorn Chiang Mai Hospital ( Site 1800) Muang, Chiang Mai | |
| Marmara Universitesi Pendik Egitim Arastirma Hastanesi ( Site 1408) Istanbul, | |
| McGill University Health Centre ( Site 0106) Montreal, Quebec | |
| Medical Oncology Associates, PS (dba Summit Cancer Centers) ( Site 0010) Spokane, Washington | |
| Mega Medipol ( Site 1412) Istanbul, | |
| MidAmerica Cancer Care, LLC ( Site 0043) Kansas City, Missouri | |
| Moores Cancer Center ( Site 0003) La Jolla, California | |
| Nagoya University Hospital ( Site 1907) Nagoya, Aichi-ken | |
| Naresuan University Hospital ( Site 1804) Muang, Changwat Phitsanulok | |
| Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1000) Gliwice, Silesian Voivodeship | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site 1004) Warsaw, Masovian Voivodeship | |
| National Cheng Kung University Hospital ( Site 1700) Tainan, | |
| National Taiwan University Hospital ( Site 1701) Taipei, | |
| Netcare Pretoria East Hospital-Alberts Cellular Therapy ( Site 1101) Pretoria, Gauteng | |
| New York Oncology Hematology, P.C. ( Site 0069) Albany, New York | |
| North Shore Hospital-Department of Haematology ( Site 3200) Auckland, | |
| Odense Universitetshospital-Department of Hematology ( Site 0401) Odense C, Region Syddanmark | |
| Okayama University Hospital ( Site 1912) Okayama, | |
| Ondokuz Mays Üniversitesi ( Site 1410) Samsun, | |
| Onkologische Schwerpunktpraxis Kurfuerstendamm ( Site 0600) Berlin, | |
| Oslo Universitetssykehus Rikshospitalet-Avdeling for blodsykdommer ( Site 0901) Oslo, | |
| Parkview Research Center at Parkview Regional Medical Center ( Site 0002) Fort Wayne, Indiana | |
| Peking University First Hospital ( Site 2022) Beijing, Beijing Municipality | |
| Peking University Third Hospital-Hematology ( Site 2011) Beijing, Beijing Municipality | |
| Pratia MCM Krakow ( Site 1007) Krakow, Lesser Poland Voivodeship | |
| Pratia Onkologia Katowice ( Site 1009) Katowice, Silesian Voivodeship | |
| Queen Elizabeth Hospital ( Site 1603) Kota Kinabalu, Sabah | |
| Queen Mary Hospital ( Site 3300) Hong Kong, | |
| RPCI Oncology, PC- Northtowns ( Site 0061) Williamsville, New York | |
| Rabin Medical Center ( Site 1504) Petah Tikva, | |
| Rambam Health Care Campus-Hematology and Bone Marrow Transplantation ( Site 1503) Haifa, | |
| Regions Hospital ( Site 0042) Saint Louis Park, Minnesota | |
| Roskilde Sygehus-Department of Hematology ( Site 0402) Roskilde, Region Sjælland | |
| Roswell Park Cancer Institute ( Site 0023) Buffalo, New York | |
| Royal Lancaster Infirmary ( Site 3012) Lancaster, Lancashire | |
| Royal North Shore Hospital ( Site 2806) St Leonards, New South Wales | |
| SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical ( Site 0048) Madison, Wisconsin | |
| Saint Elizabeth Healthcare ( Site 0041) Edgewood, Kentucky | |
| Saint Joseph Hospital ( Site 0026) Denver, Colorado | |
| Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Olsztynie-Oddzial Kliniczny Hematologii ( Site 1005) Olsztyn, Warmian-Masurian Voivodeship | |
| Shaanxi provincial people's hospital ( Site 2012) Xi'an, Shaanxi | |
| Shandong Cancer Hospital ( Site 2003) Jinan, Shandong | |
| Shanxi Cancer Hospital ( Site 2033) Taiyuan, Shanxi | |
| Sheba Medical Center-Hemato Oncology ( Site 1501) Ramat Gan, | |
| Shimane University Hospital ( Site 1911) Izumo, Shimane | |
| Sisli Florence Nightingale Hastanesi ( Site 1411) Istanbul, | |
| Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 2405) Valledupar, Cesar Department | |
| Songklanagarind hospital ( Site 1803) Hat Yai, Changwat Songkhla | |
| Southeastern Medical Oncology Center ( Site 0049) Goldsboro, North Carolina | |
| Southern Medical University Nanfang Hospital-Department of Hematopathology ( Site 2006) Guangzhou, Guangdong | |
| Southmead Hospital ( Site 3010) Bristol, Bristol, City of | |
| St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 3006) London, London, City of | |
| St James's University Hospital ( Site 3004) Leeds, | |
| Summit Medical Group Cancer Center ( Site 0007) Florham Park, New Jersey | |
| Sun Yat-sen University Cancer Center ( Site 2028) Guangzhou, Guangdong | |
| Sykehuset i Vestfold ( Site 0903) Tønsberg, Vestfold | |
| Tennessee Oncology, PLLC - Elliston Place Plaza Medical Oncology & Hematology ( Site 0031) Nashville, Tennessee | |
| Tennessee Oncology-Chattanooga ( Site 0045) Chattanooga, Tennessee | |
| Texas Oncology - Central/South Texas ( Site 8008) Austin, Texas | |
| Texas Oncology - Northeast Texas ( Site 8012) Tyler, Texas | |
| Texas Oncology - San Antonio ( Site 8006) San Antonio, Texas | |
| The Affiliated Hospital of Guizhou Medical University ( Site 2024) Guiyang, Guizhou | |
| The Affiliated Hospital of Xuzhou Medical College ( Site 2013) Xuzhou, Jiangsu | |
| The Center for Cancer and Blood Disorders ( Site 0032) Fort Worth, Texas | |
| The Churchill Hospital ( Site 3007) Oxford, Oxfordshire | |
| The First Affiliated Hospital of Nanchang University ( Site 2023) Nanchang, Jiangxi | |
| The First Affliated Hospital of Suzhou University ( Site 2027) Suzhou, Jiangsu | |
| The First Hospital of Jilin University-Hematology ( Site 2030) Changchun, Jilin | |
| The Ottawa Hospital - General Campus ( Site 0102) Ottawa, Ontario | |
| The Second Xiangya Hospital of Central South University ( Site 2010) Changsha, Hunan | |
| The first Affiliated Hospital, Zhejiang University School of Medicine-Hematology ( Site 2002) Hangzhou, Zhejiang | |
| Tianjin Medical University Cancer Institute & Hospital-lymphoma ( Site 2019) Tianjin, Tianjin Municipality | |
| Tohoku University Hospital ( Site 1901) Sendai, Miyagi | |
| Tongji Hospital Affiliated to Tongji Medical College of HUST ( Site 2016) Wuhan, Hubei | |
| Trakya University Medical Faculty Hospital-Hematology ( Site 1403) Edirne, | |
| USA Mitchell Cancer Institute ( Site 0014) Mobile, Alabama | |
| UZ Leuven-Hematology ( Site 0200) Leuven, Vlaams-Brabant | |
| Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 3107) Vila Nova de Gaia, Porto District | |
| Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 3104) Lisbon, | |
| Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 3106) Lisbon, | |
| Universitaetsklinikum Ulm. ( Site 0601) Ulm, Baden-Wurttemberg | |
| University Hospital and UW Health Clinics ( Site 0006) Madison, Wisconsin | |
| University Hospital of Alexandroupolis ( Site 0701) Alexandroupoli, East Macedonia and Thrace | |
| University Hospital of Ioannina ( Site 0702) Ioannina, | |
| University Malaya Medical Centre ( Site 1604) Lembah Pantai, Kuala Lumpur | |
| University of Iowa Health Care. ( Site 0017) Waukee, Iowa | |
| University of Iowa Health Care. ( Site 0057) Waukee, Iowa | |
| University of Virginia Cancer Center ( Site 0040) Charlottesville, Virginia | |
| Universitätsklinikum Halle ( Site 0604) Halle, Saxony-Anhalt | |
| Uniwersytecki Szpital Kliniczny nr 1 w Lublinie-Oddział Hematoonkologii-Transplantacji Szpiku i Chem ( Site 1006) Lublin, Lublin Voivodeship | |
| Uniwersyteckie Centrum Kliniczne-Klinika Hematologii i Transplantologii ( Site 1011) Gdansk, Pomeranian Voivodeship | |
| VK&K Studien GbR ( Site 0607) Landshut, Bavaria | |
| Virginia Commonwealth University (VCU) Medical Center ( Site 0030) Richmond, Virginia | |
| Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0302) Prague, | |
| Waikato Hospital-Haematology ( Site 3202) Hamilton, Waikato Region | |
| West China Hospital, Sichuan University-Head and Neck Oncology ( Site 2026) Chengdu, Sichuan | |
| William Osler Health System ( Site 0103) Brampton, Ontario | |
| Wits Clinical Research ( Site 1102) Johannesburg, Gauteng | |
| Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku-Oddział Hematologii i Transplantacji ( Site 1013) Słupsk, Pomeranian Voivodeship | |
| Xinjiang Medical University Cancer Hospital - Urumqi ( Site 2014) Ürümqi, Xinjiang | |
| Yamagata University Hospital ( Site 1902) Yamagata, | |
| Yitzhak Shamir Medical Center. ( Site 1506) Ẕerifin, | |
| Zhejiang Cancer Hospital ( Site 2017) Hangzhou, Zhejiang | |
| hospital universitario de canarias ( Site 1205) San Cristóbal de La Laguna, Santa Cruz De Tenerife |
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma (SUPRAME)
Immatics US, Inc. - ctgovinquiries@immatics.com
NCT06743126
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Inclusion Criteria:
* Pathologically confirmed and documented cutaneous melanoma- CM patients (including acral melanoma and melanoma of unknown primary) with unresectable or metastatic disease
* HLA-A\*02:01 positive
* Adequate selected organ function per protocol
* Eastern Cooperative Oncology Group (ECOG) performance status 0-1
* Disease progression (resistance, toxicity) on or after at least one PD-1 inhibitor, applied either as monotherapy or in combination with other therapies as treatment for unresectable or metastatic cutaneous melanoma
* Patients with BRAF mutation should have been treated with one prior line of BRAF-directed therapy (with or without a MEK inhibitor) prior to initial eligibility assessment, unless deemed not clinically indicated at Investigator's discretion due to concurrent medical condition, prior toxicity, or if declined by the patient
* Life expectancy more than 6 months
* Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1)
* Female patient of childbearing potential must use adequate contraception from randomization until 12 months after the infusion of IMA203 or in line with the instructions provided for investigator's choice treatment (in the control arm)
* Male patient must agree to use effective contraception or be abstinent while on study and for 6 months after the infusion of IMA203 or in line with the instructions provided for investigator's choice treatment (in the control arm)
* The patient must have recovered from any side effects of prior therapy to Grade 1 or lower prior to randomization and prior to trial treatment start.
Exclusion Criteria:
* Primary mucosal or uveal melanoma
* History of other malignancies (except for adequately treated basal or squamous cell carcinoma or carcinoma in situ) within the last 3 years
* Serious autoimmune disease Note: At the discretion of the investigator, these patients may be included if their disease is well controlled without the use of immunosuppressive agents.
* History of cardiac conditions as per protocol
* Prior allogenic stem cell transplantation or solid organ transplantation
* Concurrent severe and/or uncontrolled medical disease that could compromise participation in the study
* History of or current immunodeficiency disease or prior treatment compromising immune function at the discretion of the treating physician
* History of hypersensitivity to CY, FLU, or IL-2 or presence of any contraindications and other limitations for planned treatment with investigator's choice as laid down in the current versions of the respective PIs / SmPCs
* Known hypersensitivity to any of the rescue medications
* History of or current immunodeficiency disease or prior treatment compromising immune function at the discretion of the investigator
* Positive for HIV infection or with active hepatitis B virus (HBV) or active hepatitis C virus (HCV) infection.
* Any condition contraindicating leukapheresis
* Pregnant or breastfeeding
* Any other condition that would, in the investigator's or sponsor's judgment, contraindicate the patient's participation in the clinical trial because of safety concerns or compliance with clinical trial procedures (e.g., psychiatric disorders or substance dependence, neurological impairment)
* Patient has received systemic corticosteroids within 2 weeks prior to leukapheresis,
* Patient has received surgery or other anti-cancer therapies, any agent that is likely to suppress bone marrow function, or investigational medicinal products within 7 days prior to leukapheresis.
* Patients with any active infection or ongoing reactivation of infection
* Patients who underwent non-myeloablative lymphodepletion prior to cell therapy within the last 6 months
* Prior treatment with IMA203
* Patients with ascites, pleural or pericardial effusion which requires repeated (2 within 4 weeks) or continuous paracentesis, thoracentesis or pericardiocentesis within last 2 months
* Patients with LDH greater than 2.0-fold ULN
* Concurrent treatment in another clinical trial or a device study that could interfere with the IMA203 treatment or planned investigator's choice treatment
* Patients with active brain metastases or leptomeningeal metastases
* Patient has received any investigational therapies, inactivated vaccines, chronic use of systemic corticosteroids or IV antibiotics within 1 week prior to randomization, or live vaccines within 4 weeks prior to randomization
* Patient has received any anti-cancer therapy (prior anti-cancer treatment or bridging therapy) or radiotherapy within 1 week prior to start of trial treatment
* Other protocol defined inclusion/exclusion criteria could apply BIOLOGICAL: IMA203, BIOLOGICAL: nivolumab plus relatlimab, BIOLOGICAL: lifileucel, BIOLOGICAL: nivolumab, BIOLOGICAL: pembrolizumab, BIOLOGICAL: ipilimumab, DRUG: Dacarbazine, DRUG: temozolomide, DRUG: paclitaxel, DRUG: paclitaxel plus carboplatin, DRUG: Albumin-Bound Paclitaxel
Melanoma, Cutaneous Malignant
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Show 66 locations
Study Locations
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| Location | Contacts |
|---|---|
| Assistance Publique Hopitaux De Paris, Hôpital Saint Louis Paris, | |
| Atlantic Health System/Morristown Medical Center Morristown, New Jersey | |
| Avera Cancer Institute Sioux Falls, South Dakota | Benjamin Solomon, MD - (Benjamin.Solomon@avera.org) |
| BC Cancer - Vancouver Vancouver, British Columbia | |
| Baylor University Dallas, Texas | |
| Beth Israel Deaconess Medical Center Boston, Massachusetts | David McDermott, MD - (dmcdermo@bidmc.harvard.edu) |
| Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital Cambridge, | |
| Centre Hospitalier Universitaire de Lille Lille, | |
| Charite Universitaetsmedizin Berlin KöR Berlin, | |
| City of Hope National Medical Center Duarte, California | Yan Xing, MD - (yxing@coh.org) |
| Cleveland Clinic, Taussig Cancer Institute Cleveland, Ohio | James Isaac - (isaacsj3@ccf.org) |
| Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) Rotterdam, | |
| Fox Chase Cancer Center Philadelphia, Pennsylvania | Anthony J Olszanski, MD, RPh - (Anthony.Olszanski@FCCC.edu) |
| Fred Hutchinson Cancer Center Seattle, Washington | Sylvia Lee, MD - (leesm@uw.edu) |
| Goethe University Frankfurt Frankfurt am Main, | |
| Greater Glasgow and Clyde NHS, Beatson West of Scotland Cancer Center Glasgow, | |
| Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital London, | |
| Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting Amsterdam, | |
| Honor Health Research Institute Scottsdale, Arizona | Justin Moser, MD - (jmoser@honorhealth.com) |
| Huntsman Cancer Institute, University of Utah Salt Lake City, Utah | Siwen Hu-Lieskovan, MD, PhD - (Siwen.Hu-Leiskovan@hci.utah.edu) |
| Institut Gustave Roussy Villejuif, | |
| Laura and Isaac Perlmutter Cancer Center At Nyu Langone Health New York, New York | Maya Dimitrova, MD - (maya.dimitrova@nyulangone.org) |
| Lehigh Valley Topper Cancer Institute Allentown, Pennsylvania | |
| Massachusetts General Hospital Boston, Massachusetts | |
| Mayo Clinic Rochester, Minnesota | Seetharam Mahesh, MD - (Seetharam.Mahesh@mayo.edu) |
| Mayo Clinic Rochester, Minnesota | |
| Mayo Clinic Florida Jacksonville, Florida | |
| Memorial Sloan Kettering Cancer Center New York, New York | James Smithy, MD - (smithyj@mskcc.org) |
| Moffitt Cancer Center Tampa, Florida | |
| Ohio State University Columbus, Ohio | |
| Oxford University Hospitals NHS Foundation Trust, Churchill Hospital Oxford, | |
| Providence Cancer Institute Franz Clinic Portland, Oregon | Matthew Taylor, MD - (Matthew.Taylor@providence.org) |
| SCRI Oncology Partners Nashville, Tennessee | |
| Stanford Cancer Center Palo Alto, California | Alison Betof Warner, MD, PhD - (allison.betof@stanford.edu) |
| Technische Universitaet Dresden Dresden, | |
| The Christie NHS Foundation Trust Manchester, | |
| The Royal Marsden NHS Foundation Trust London, | |
| The University of Texas MD Anderson Cancer Center Houston, Texas | Rodabe N Amaria, MD - (RNAmaria@mdanderson.org) |
| Thomas Jeffersion University, Sidney Kimmel Cancer Center Philadelphia, Pennsylvania | Rino Seedor, MD - (Rino.Seedor@jefferson.edu) |
| UC San Diego Moores Cancer Center La Jolla, California | Gregory Daniels, MD - (gdaniels@health.ucsd.edu) |
| UCLA Hematology/Oncology Los Angeles, California | Bartosz Chmielowski, MD, PhD - (bchmielowski@mednet.ucla.edu) |
| UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California | Adil Daud, MD - (adil.daud@ucsf.edu) |
| UNC Hospitals, The University of North Carolina at Chapel Hill Chapel Hill, North Carolina | Stergios Moschos, MD - (stergios_moschos@med.unc.edu) |
| UPMC Hillman Cancer Center Pittsburgh, Pennsylvania | Jason J Luke, M.D. - (lukejj@upmc.edu) |
| Universitaet Leipzig Leipzig, | |
| Universitaetsklinikum Bonn AöR Bonn, | |
| Universitaetsklinikum Erlangen AöR Erlangen, | |
| Universitaetsklinikum Essen AöR Essen, | |
| Universitaetsklinikum Heidelberg AöR Heidelberg, | |
| Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR Mainz, | |
| Universitair Medisch Centrum Groningen Groningen, | |
| Universitatsklinikum Koeln Cologne, Northrhine-W Estphalia | |
| University Health Network, Princess Margaret Cancer Centre Toronto, Ontario | Marcus Butler, MD - (Marcus.Butler@uhn.ca) |
| University Medical Center Hamburg-Eppendorf Hamburg, | |
| University of Chicago Medical Center Chicago, Illinois | Daniel Olson, MD - (dolson2@medicine.bsd.uchicago.edu) |
| University of Colorado, Anschutz Medical Campus Aurora, Colorado | |
| University of MD Greenebaum Comprehensive Cancer Center Baltimore, Maryland | Petra Hausner, MD, PhD - (phausner@umm.edu) |
| University of Miami - Sylvester Comprehensive Cancer Cente Miami, Florida | Leonel Hernandez-Aya, MD - (l.hernandezaya@med.miami.edu) |
| University of Michigan Ann Arbor, Michigan | Leslie Fecher, MD - (lfecher@med.umich.edu) |
| University of Nebraska Medical Center Omaha, Nebraska | Bhavina Sharma, MD - (bhsharma@unmc.edu) |
| University of Pennsylvania, Abramson Cancer Center Philadelphia, Pennsylvania | |
| University of Rochester Rochester, New York | Sahasrabudhe Deepak, MD - (deepak_sahasrabudhe@urmc.rochester.edu) |
| University of Southampton NHS Foundation Trust, Southampton General Hospital Southampton, | |
| University of Texas Southwestern Medical Center Dallas, Texas | Sanjay Chandrasekaran, MD - (Sanjay.Chandrasekaran@utsouthwestern.edu) |
| Virginia Commonwealth University Henrico, Virginia | Andrew Poklepovic, MD - (andrew.poklepovic@vcuhealth.org) |
| Yale Cancer Center New Haven, Connecticut |
Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors
Director Regulatory Affairs - langerj@nrgoncology.org
NCT05896189
Show full eligibility criteria
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Inclusion Criteria:
* The participant must provide study-specific informed consent prior to any study specific procedures and authorization permitting release of personal health information.
* The participant must have a first time diagnosis of non-metastatic breast cancer which is Stage I-III.
* The participant must have a score of less than 12 on the PROMIS Adult v2.0 - Cognitive Function 4a.
* Participants must be at least 6 months and no more than 5 years (after completion of initial surgery +/- adjuvant chemotherapy/radiation therapy) and targeted therapies (e.g., PARP inhibitors, CDK4/6, or immunotherapy). Participants may still be taking endocrine therapy and/or trastuzumab.
* The participant must be able to understand, speak, read, and write in English or Spanish.
Exclusion Criteria:
* Scoring less than or equal to 3 on the 6-item cognitive screen.
* Patient Health Questionnaire-2 item (PHQ-2) score of greater than or equal to 3.
* Definitive clinical or radiologic evidence of metastatic disease.
* Current or past history of another cancer. Patients with history of only non-melanoma skin cancer or in situ cervical cancer without chemotherapy treatment would be eligible.
* Previous exposure to chemotherapy treatment for another cancer or due to other medical condition (e.g. methotrexate exposure for treatment of rheumatoid arthritis).
* Previous central nervous system (CNS) radiation, intrathecal therapy or CNS-involved surgery.
* Participants with history of stroke, traumatic brain injury, brain surgery, Alzheimer's disease or other dementia.
* Participants with active substance abuse and/or in treatment for substance abuse, or history of bipolar disorder, psychosis, schizophrenia, ADHD, or learning disability.
* Participants who are enrolled in an active behavioral intervention (e.g., occupational therapy, physical therapy, etc.) or pharmaceutical intervention or who are in the follow-up phase of a cancer control trial or therapeutic trial that has extensive PRO follow-up after treatment ends. Participants who are enrolled in a therapeutic trial in which they have completed active treatment and require only minimal follow-up monitoring of toxicity and/or survival analysis (cancer-related mortality or all-cause mortality) would be eligible.
* Hearing impairment unless adequately corrected with hearing aids to be able to hear over the phone for the neuropsychological testing. BEHAVIORAL: Arm 1: Computerized Cognitive Training-Global Stimulation Games, BEHAVIORAL: Arm 2: Computerized Cognitive Training-Neuroplasticity Games
Breast Cancer, Cognitive Impairments
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Show 680 locations
Study Locations
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| Location | Contacts |
|---|---|
| AIS Cancer Center at San Joaquin Community Hospital Bakersfield, California | |
| Abbott-Northwestern Hospital Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Addison Gilbert Hospital Gloucester, Massachusetts | |
| Adena Regional Medical Center Chillicothe, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Advanced Breast Care Center PLLC Warren, Michigan | |
| Alaska Breast Care and Surgery LLC Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Alaska Oncology and Hematology LLC Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Alaska Women's Cancer Care Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Alegent Health Bergan Mercy Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Immanuel Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Lakeside Hospital Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Mercy Hospital Council Bluffs, Iowa | |
| Allegiance Health Jackson, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| AnMed Health Cancer Center Anderson, South Carolina | Site Public Contact - (rhonda.ballew@anmedhealth.org) |
| Anchorage Associates in Radiation Medicine Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Anchorage Radiation Therapy Center Anchorage, Alaska | |
| Annie Penn Memorial Hospital Reidsville, North Carolina | Site Public Contact - (stacey.phelps@conehealth.com) |
| Arizona Center for Cancer Care Tempe, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care - Biltmore Phoenix, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care - Gilbert Gilbert, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care - Osborn Scottsdale, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care - Phoenix Phoenix, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care - Scottsdale Scottsdale, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care-Peoria Peoria, Arizona | |
| Arizona Center for Cancer Care-Surprise Surprise, Arizona | Site Public Contact - (Roster@nrgoncology.org) |
| Armes Family Cancer Center Findlay, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Ascension Via Christi Hospitals Wichita Wichita, Kansas | Site Public Contact - (research@viachristi.org) |
| BASS Medical Group - Lennon Walnut Creek, California | Site Public Contact - (brenna.lindsey@bassmedicalgroup.com) |
| BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri | |
| Baptist Cancer Center-Grenada Grenada, Mississippi | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Desoto Southhaven, Mississippi | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus, Mississippi | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Oxford Oxford, Mississippi | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Union County New Albany, Mississippi | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital for Women Memphis, Tennessee | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Bay Area Hospital Coos Bay, Oregon | Site Public Contact - (cherie.cox@bayareahospital.org) |
| Beacon Kalamazoo Kalamazoo, Michigan | |
| Beacon Kalamazoo Cancer Center Kalamazoo, Michigan | |
| Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care Winchester, Massachusetts | |
| Bethesda North Hospital Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Beverly Hospital Beverly, Massachusetts | |
| Bhadresh Nayak MD PC-Sterling Heights Sterling Heights, Michigan | |
| Blanchard Valley Hospital Findlay, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Bon Secours Cancer Institute at Reynolds Crossing Richmond, Virginia | Site Public Contact - (Anne_caramella@bshsi.org) |
| Bon Secours Memorial Regional Medical Center Mechanicsville, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Richmond Community Hospital Richmond, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Saint Francis Medical Center Midlothian, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Saint Mary's Hospital Richmond, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Westchester Emergency Center Midlothian, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Boulder Community Foothills Hospital Boulder, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Broadlawns Medical Center Des Moines, Iowa | |
| Bronson Battle Creek Battle Creek, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Bronson Methodist Hospital Kalamazoo, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Broward Health Medical Center Fort Lauderdale, Florida | Site Public Contact - (Allison.bruce@nemours.org) |
| Broward Health North Deerfield Beach, Florida | |
| CARTI Cancer center Little Rock, Arkansas | Site Public Contact - (Research@CARTI.com) |
| CHI Health Good Samaritan Kearney, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| CHI Health Saint Francis Grand Island, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| CTCA at Southeastern Regional Medical Center Newnan, Georgia | |
| CTCA at Western Regional Medical Center Goodyear, Arizona | |
| Cancer Care Associates PC Royal Oak, Michigan | |
| Cancer Care Center of O'Fallon O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Care Northwest - Spokane South Spokane, Washington | Site Public Contact - (research@ccnw.net) |
| Cancer Care Northwest-North Spokane Spokane, Washington | Site Public Contact - (research@ccnw.net) |
| Cancer Care Northwest-Valley Spokane, Washington | Site Public Contact - (research@ccnw.net) |
| Cancer Care Specialists of Illinois - Decatur Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Center at Saint Joseph's Phoenix, Arizona | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Cancer Center of Kansas - Chanute Chanute, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Dodge City Dodge City, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - El Dorado El Dorado, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - McPherson McPherson, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Newton Newton, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Parsons Parsons, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Pratt Pratt, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Salina Salina, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Wellington Wellington, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Wichita Wichita, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Winfield Winfield, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas-Independence Independence, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas-Kingman Kingman, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas-Liberal Liberal, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Western Wisconsin New Richmond, Wisconsin | Site Public Contact - (mmcorc@healthpartners.com) |
| Cancer Center-Metro Medical Center Bayamon Bayamón, | |
| Cancer Hematology Centers - Flint Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan | Site Public Contact - (connie.szczepanek@crcwm.org) |
| Carilion Roanoke Memorial Hospital Roanoke, Virginia | |
| Carle BroMenn Medical Center Normal, Illinois | Site Public Contact - (Research@Carle.com) |
| Carle Cancer Center Urbana, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Cancer Institute Normal Normal, Illinois | Site Public Contact - (Research@Carle.com) |
| Carle Physician Group-Effingham Effingham, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | Site Public Contact - (Research@carle.com) |
| Carle at The Riverfront Danville, Illinois | Site Public Contact - (Research@Carle.com) |
| Caro Cancer Center Caro, Michigan | |
| Castle Medical Center Kailua, Hawaii | |
| Cedars Sinai Medical Center Los Angeles, California | |
| Central Care Cancer Center - Bolivar Bolivar, Missouri | Site Public Contact - (aroland@kccop.org) |
| Central Care Cancer Center - Garden City Garden City, Kansas | Site Public Contact - (aroland@kccop.org) |
| Central Care Cancer Center - Great Bend Great Bend, Kansas | Site Public Contact - (aroland@kccop.org) |
| Central Ohio Breast and Endocrine Surgery Gahanna, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Centralia Oncology Clinic Centralia, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Centro Comprensivo de Cancer de UPR San Juan, | Site Public Contact - (Roster@nrgoncology.org) |
| Chelsea Hospital Chelsea, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Chester County Hospital West Chester, Pennsylvania | |
| Clackamas Radiation Oncology Center Clackamas, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Cleveland Clinic Akron General Akron, Ohio | Site Public Contact - (CancerAnswer@ccf.org) |
| Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center Wilmington, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Colorado Blood Cancer Institute Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| CommonSpirit Cancer Center Mercy Durango, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Commonwealth Cancer Center-Corbin Corbin, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Community Medical Center Missoula, Montana | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Comprehensive Medical Center PLLC Royal Oak, Michigan | |
| Cone Health Cancer Center Greensboro, North Carolina | Site Public Contact - (stacey.phelps@conehealth.com) |
| Cone Health Cancer Center at Alamance Regional Burlington, North Carolina | Site Public Contact - (stacey.phelps@conehealth.com) |
| Cone Health Cancer Center at Asheboro Asheboro, North Carolina | |
| Cone Health Cancer Center at Drawbridge Parkway Greensboro, North Carolina | Site Public Contact - (stacey.phelps@conehealth.com) |
| Cone Health MedCenter Asheboro Asheboro, North Carolina | Site Public Contact - (stacey.phelps@conehealth.com) |
| Contra Costa Regional Medical Center Martinez, California | |
| Cooper Hospital University Medical Center Camden, New Jersey | |
| Corewell Health Beaumont Troy Hospital Troy, Michigan | |
| Corewell Health Dearborn Hospital Dearborn, Michigan | |
| Corewell Health Farmington Hills Hospital Farmington Hills, Michigan | |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Lakeland Hospitals - Niles Hospital Niles, Michigan | |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Reed City Hospital Reed City, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health William Beaumont University Hospital Royal Oak, Michigan | |
| Cotton O'Neil Cancer Center / Stormont Vail Health Topeka, Kansas | |
| Cox Cancer Center Branson Branson, Missouri | |
| CoxHealth South Hospital Springfield, Missouri | |
| Creighton University Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Crossroads Cancer Center Effingham, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Dayton Physician LLC - Englewood Dayton, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Dayton Physicians LLC - Troy Troy, Ohio | |
| Dayton Physicians LLC-Atrium Franklin, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Dayton Physicians LLC-Miami Valley South Centerville, Ohio | |
| Dayton Physicians LLC-Wayne Greenville, Ohio | |
| Decatur Memorial Hospital Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Doctors Cancer Center Manati, | |
| Duluth Clinic Ashland Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Edward Hospital/Cancer Center Naperville, Illinois | |
| Edward Hospital/Cancer Center?Plainfield Plainfield, Illinois | Site Public Contact - (Cancerresearch@edward.org) |
| Edwards Comprehensive Cancer Center Huntington, West Virginia | Site Public Contact - (Christina.Cole@chhi.org) |
| Elmhurst Memorial Hospital Elmhurst, Illinois | Site Public Contact - (Jrohde@emhc.org) |
| Englewood Hospital and Medical Center Englewood, New Jersey | |
| Enloe Medical Center Chico, California | |
| Essentia Health - Baxter Clinic Baxter, Minnesota | |
| Essentia Health - Deer River Clinic Deer River, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Ely Clinic Ely, Minnesota | |
| Essentia Health - Fosston Fosston, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - International Falls Clinic International Falls, Minnesota | |
| Essentia Health - Jamestown Clinic Jamestown, North Dakota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Moose Lake Clinic Moose Lake, Minnesota | |
| Essentia Health - Park Rapids Park Rapids, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Saint Joseph's Crosslake Clinic Crosslake, Minnesota | |
| Essentia Health - Saint Joseph's Pequot Lakes Clinic Pequot Lakes, Minnesota | |
| Essentia Health - Saint Joseph's Pine River Clinic Pine River, Minnesota | |
| Essentia Health - Saint Joseph's Staples Clinic Staples, Minnesota | |
| Essentia Health Cancer Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center-South University Clinic Fargo, North Dakota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Hibbing Clinic Hibbing, Minnesota | |
| Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Saint Mary's Hospital - Superior Superior, Wisconsin | |
| Essentia Health Saint Mary's Medical Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Sandstone Sandstone, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Virginia Clinic Virginia, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Hayward Clinic Hayward, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Spooner Clinic Spooner, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| FMH James M Stockman Cancer Institute Frederick, Maryland | |
| Fairbanks Memorial Hospital Fairbanks, Alaska | Site Public Contact - (Veronica.Stevenson@foundationhealth.org) |
| Fairfield Medical Center Lancaster, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Lakes Medical Center Wyoming, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Northland Medical Center Princeton, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Southdale Hospital Edina, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Flaget Memorial Hospital Bardstown, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Frederick Memorial Hospital Frederick, Maryland | |
| Frederick Memorial Hospital Crestwood Frederick, Maryland | Site Public Contact - (ctsucontact@westat.com) |
| Freeman Health System Joplin, Missouri | Site Public Contact - (LJCrockett@freemanhealth.com) |
| Freeman Physician Group of Pittsburg Pittsburg, Kansas | Site Public Contact - (BNMathew@freemanhealth.com) |
| Fremont - Rideout Cancer Center Marysville, California | |
| Fresno Cancer Center Fresno, California | Site Public Contact - (Kpoct@kp.org) |
| Garnet Health Medical Center Middletown, New York | Site Public Contact - (jgerlach@garnethealth.org) |
| Geisinger Cancer Center Dickson City Dickson City, Pennsylvania | Site Public Contact - (hemoncctrials@geisinger.edu) |
| Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center Danville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Oncology-Selinsgrove Selinsgrove, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Gene Upshaw Memorial Tahoe Forest Cancer Center Truckee, California | |
| Genesee Hematology Oncology PC Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Genesis Healthcare System Cancer Care Center Zanesville, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Genesys Hurley Cancer Institute Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| George Washington University Medical Center Washington D.C., District of Columbia | |
| Gibbs Cancer Center-Gaffney Gaffney, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Gibbs Cancer Center-Pelham Greer, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Glens Falls Hospital Glens Falls, New York | |
| Good Samaritan Hospital - Cincinnati Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Goshen Center for Cancer Care Goshen, Indiana | Site Public Contact - (cccois@goshenhealth.com) |
| Greater Dayton Cancer Center Kettering, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Greater Regional Medical Center Creston, Iowa | |
| HSHS Saint Elizabeth's Hospital O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Halifax Health Center for Oncology - Ormond Beach Ormond Beach, Florida | Site Public Contact - (debbie.reynolds@halifax.org) |
| Halifax Health Center for Oncology - Port Orange Port Orange, Florida | Site Public Contact - (debbie.reynolds@halifax.org) |
| Halifax Health Medical Center-Centers for Oncology Daytona Beach, Florida | |
| Hawaii Cancer Care - Westridge ‘Aiea, Hawaii | Site Public Contact - (info@hawaiicancercare.com) |
| Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii | Site Public Contact - (i.webster@hawaiicancercare.com) |
| Hawaii Diagnostic Radiology Services LLC Honolulu, Hawaii | Site Public Contact - (mmiyoshi@hawaiidrs.com) |
| HaysMed Hays, Kansas | |
| Heartland Regional Medical Center Saint Joseph, Missouri | Site Public Contact - (Trisha.England2@mymlc.com) |
| Hematology Oncology Associates of CNY at Camillus Camillus, New York | |
| Hematology Oncology Associates of Central New York-Auburn Auburn, New York | |
| Hematology Oncology Associates of Central New York-East Syracuse East Syracuse, New York | |
| Hematology Oncology Consultants PC-Royal Oak Royal Oak, Michigan | |
| Hematology Oncology Consultants PC-Troy Troy, Michigan | |
| Hematology Oncology Consultants-Clarkston Clarkston, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Hennepin County Medical Center Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Henry Ford Cancer Institute-Downriver Brownstown, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Health Providence Novi Hospital Novi, Michigan | Site Public Contact - (kfife3@hfhs.org) |
| Henry Ford Health Providence Southfield Hospital Southfield, Michigan | Site Public Contact - (kfife3@hfhs.org) |
| Henry Ford Health Saint John Hospital Detroit, Michigan | Site Public Contact - (Kkeenan1@hfhs.org) |
| Henry Ford Health Warren Hospital Warren, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Hospital Detroit, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Madison Heights Hospital - Breast Warren, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Medical Center-Columbus Novi, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Medical Center-Fairlane Dearborn, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford River District Hospital East China Township, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Saint John Hospital - Academic Grosse Pointe Woods, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Saint John Hospital - Breast Grosse Pointe Woods, Michigan | Site Public Contact - (karen.forman@ascension.org) |
| Henry Ford Saint John Hospital - Macomb Medical Macomb, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Saint John Hospital - Van Elslander Grosse Pointe Woods, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Warren Hospital - Breast Macomb Macomb, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Warren Hospital - GLCMS Warren, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford West Bloomfield Hospital West Bloomfield, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Wyandotte Hospital Wyandotte, Michigan | Site Public Contact - (nhay@hfhs.org) |
| Holy Cross Hospital Silver Spring, Maryland | Site Public Contact - (eileen.georgi@holy-cross.com) |
| Hope Cancer Center Pontiac, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Hurley Medical Center Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Huron Gastroenterology PC Ypsilanti, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| IU Health North Hospital Carmel, Indiana | |
| Idaho Urologic Institute-Meridian Meridian, Idaho | Site Public Contact - (stephanie.couch@stjoeshealth.org) |
| Illinois CancerCare - Washington Washington, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Bloomington Bloomington, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Canton Canton, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Carthage Carthage, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Dixon Dixon, Illinois | |
| Illinois CancerCare-Eureka Eureka, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Galesburg Galesburg, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Kewanee Clinic Kewanee, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Macomb Macomb, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Ottawa Clinic Ottawa, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Pekin Pekin, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peoria Peoria, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peru Peru, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Princeton Princeton, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana | Site Public Contact - (iutrials@iu.edu) |
| Indu and Raj Soin Medical Center Beavercreek, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Inova Alexandria Hospital Alexandria, Virginia | Site Public Contact - (Stephanie.VanBebber@inova.org) |
| Inova Fair Oaks Hospital Fairfax, Virginia | Site Public Contact - (Stephanie.VanBebber@inova.org) |
| Inova Fairfax Hospital Falls Church, Virginia | Site Public Contact - (Stephanie.VanBebber@inova.org) |
| Inova Loudoun Hospital Leesburg, Virginia | Site Public Contact - (Keary.janet@inova.org) |
| Inova Schar Cancer Institute Fairfax, Virginia | Site Public Contact - (Stephanie.VanBebber@inova.org) |
| Iowa Methodist Medical Center Des Moines, Iowa | |
| Jackson Oncology Associates PLLC Jackson, Mississippi | |
| Jefferson Healthcare Port Townsend, Washington | |
| Jersey Shore Medical Center Neptune City, New Jersey | |
| John Fitzgerald Kennedy Medical Center Atlantis, Florida | |
| John H Stroger Jr Hospital of Cook County Chicago, Illinois | |
| John Muir Medical Center-Walnut Creek Walnut Creek, California | Site Public Contact - (clinicalresearch@johnmuirhealth.com) |
| Kadlec Clinic Hematology and Oncology Kennewick, Washington | Site Public Contact - (research@kadlecmed.org) |
| Kaiser Permanente - Kensington Medical Center Kensington, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente - Largo Medical Center Largo, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente Cancer Treatment Center South San Francisco, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente Downtown Commons Sacramento, California | Site Public Contact - (kpoct@kp.org) |
| Kaiser Permanente Dublin Dublin, California | |
| Kaiser Permanente Fresno Orchard Plaza Fresno, California | |
| Kaiser Permanente Lutherville - Timonium Medical Center Lutherville, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente Medical Center - Santa Clara Santa Clara, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii | Site Public Contact - (shelley.a.clark@kp.org) |
| Kaiser Permanente San Leandro San Leandro, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente Tysons Corner Medical Center McLean, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente- Marshall Medical Offices Redwood City, California | |
| Kaiser Permanente- Modesto MOB II Modesto, California | |
| Kaiser Permanente-Burke Medical Center Burke, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Capitol Hill Medical Center Washington D.C., District of Columbia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Caton Hill Medical Center Woodbridge, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Fremont Fremont, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Fresno Fresno, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Gaithersburg Medical Center Gaithersburg, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Modesto Modesto, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Oakland Oakland, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Richmond Richmond, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Roseville Roseville, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-San Francisco San Francisco, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Santa Rosa Santa Rosa, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Santa Teresa-San Jose San Jose, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-South Sacramento Sacramento, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-South San Francisco South San Francisco, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Stockton Stockton, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Vallejo Vallejo, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Walnut Creek Walnut Creek, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Woodlawn Medical Center Baltimore, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser San Rafael-Gallinas San Rafael, California | Site Public Contact - (Kpoct@kp.org) |
| Kapiolani Medical Center for Women and Children Honolulu, Hawaii | |
| Katmai Oncology Group Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Kettering Medical Center Kettering, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Knox Community Hospital Mount Vernon, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Kuakini Medical Center Honolulu, Hawaii | |
| Lahey Hospital and Medical Center Burlington, Massachusetts | Site Public Contact - (lhmc-cancer-clinical-trials@lahey.org) |
| Lahey Medical Center-Peabody Peabody, Massachusetts | Site Public Contact - (lhmc-cancer-clinical-trials@lahey.org) |
| Lake Regional Hospital Osage Beach, Missouri | Site Public Contact - (clinicaltrials@lakeregional.com) |
| Lakeview Hospital Stillwater, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Lawrence Memorial Hospital Lawrence, Kansas | Site Public Contact - (Stephanie.Norris@LMH.ORG) |
| Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania | Site Public Contact - (Morgan_M.Horton@lvhn.org) |
| Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania | Site Public Contact - (Morgan_M.Horton@lvhn.org) |
| Lehigh Valley Hospital-Hazleton Hazleton, Pennsylvania | Site Public Contact - (Morgan_M.Horton@lvhn.org) |
| Lexington Medical Center West Columbia, South Carolina | |
| Licking Memorial Hospital Newark, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Longmont United Hospital Longmont, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Lyndon Baines Johnson General Hospital Houston, Texas | |
| MU Health Care Goldschmidt Cancer Center Jefferson City, Missouri | |
| Macomb Hematology Oncology PC Warren, Michigan | |
| Marietta Memorial Hospital Marietta, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Marshall Cancer Center Cameron Park, California | Site Public Contact - (cancerservices@marshallmedical.org) |
| Marshfield Medical Center - Minocqua Minocqua, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center - Weston Weston, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-Marshfield Marshfield, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Mary Greeley Medical Center Ames, Iowa | |
| Mayo Clinic Health System-Eau Claire Clinic Eau Claire, Wisconsin | |
| Mayo Clinic Health System-Franciscan Healthcare La Crosse, Wisconsin | |
| Mayo Clinic Health Systems-Mankato Mankato, Minnesota | |
| Mayo Clinic Hospital in Arizona Phoenix, Arizona | |
| Mayo Clinic in Florida Jacksonville, Florida | |
| Mayo Clinic in Rochester Rochester, Minnesota | |
| McFarland Clinic - Ames Ames, Iowa | Site Public Contact - (ksoder@mcfarlandclinic.com) |
| McFarland Clinic - Boone Boone, Iowa | |
| McFarland Clinic - Jefferson Jefferson, Iowa | |
| McFarland Clinic - Marshalltown Marshalltown, Iowa | |
| McFarland Clinic - Trinity Cancer Center Fort Dodge, Iowa | |
| Mease Countryside Hospital Safety Harbor, Florida | Site Public Contact - (research.cto@baycare.org) |
| Medical University of South Carolina Charleston, South Carolina | Site Public Contact - (hcc-clinical-trials@musc.edu) |
| Memorial Hospital Chattanooga, Tennessee | Site Public Contact - (Jeffh@columbusccop.org) |
| Memorial Hospital of Carbondale Carbondale, Illinois | Site Public Contact - (clinical.research@sih.net) |
| Mercy Cancer Center Merced, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Cape Girardeau Cape Girardeau, Missouri | |
| Mercy Cancer Center - Carmichael Carmichael, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Elk Grove Elk Grove, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Rocklin Rocklin, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Sacramento Sacramento, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center-West Lakes Clive, Iowa | |
| Mercy Clinic-Rolla-Cancer and Hematology Rolla, Missouri | |
| Mercy Health - Paducah Cancer Center Paducah, Kentucky | Site Public Contact - (BJWarner@mercy.com) |
| Mercy Health - Perrysburg Hospital Perrysburg, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mercy Health - Saint Anne Hospital Toledo, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mercy Health - Saint Vincent Hospital Toledo, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mercy Health Sylvania Radiation Oncology Center Toledo, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mercy Hospital Coon Rapids, Minnesota | |
| Mercy Hospital Coon Rapids, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mercy Hospital Fort Smith Fort Smith, Arkansas | |
| Mercy Hospital Joplin Joplin, Missouri | Site Public Contact - (esmeralda.carrillo@mercy.net) |
| Mercy Hospital Oklahoma City Oklahoma City, Oklahoma | |
| Mercy Hospital Pittsburg Pittsburg, Kansas | |
| Mercy Hospital Saint Louis St Louis, Missouri | |
| Mercy Hospital South St Louis, Missouri | Site Public Contact - (Danielle.Werle@mercy.net) |
| Mercy Hospital Springfield Springfield, Missouri | |
| Mercy Hospital Washington Washington, Missouri | |
| Mercy Infusion Center - Chippewa St Louis, Missouri | |
| Mercy Medical Center Springfield, Massachusetts | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Medical Center - Des Moines Des Moines, Iowa | |
| Mercy Medical Center-West Lakes West Des Moines, Iowa | |
| Mercy Oncology and Hematology - Clayton-Clarkson Ballwin, Missouri | |
| Mercy San Juan Medical Center Carmichael, California | Site Public Contact - (OncologyResearch@DignityHealth.org) |
| Methodist Medical Center of Illinois Peoria, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Michigan Healthcare Professionals Pontiac Pontiac, Michigan | Site Public Contact - (Emily.Crofts@trinity-health.org) |
| Michigan Institute of Urology-Town Center Troy, Michigan | |
| Midlands Community Hospital Papillion, Nebraska | |
| Midwestern Regional Medical Center Zion, Illinois | |
| Miller-Dwan Hospital Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Minnesota Oncology - Burnsville Burnsville, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mission Hope Medical Oncology - Santa Maria Santa Maria, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Missouri Baptist Medical Center St Louis, Missouri | |
| Missouri Baptist Sullivan Hospital Sullivan, Missouri | |
| Monticello Cancer Center Monticello, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Morton Plant Hospital Clearwater, Florida | |
| Mount Carmel East Hospital Columbus, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mount Carmel Grove City Hospital Grove City, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mount Carmel Health Center West Columbus, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mount Carmel New Albany Surgical Hospital New Albany, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mountain Blue Cancer Care Center - Swedish Englewood, Colorado | |
| Munson Medical Center Traverse City, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| MyMichigan Medical Center Alpena Alpena, Michigan | Site Public Contact - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Gladwin Gladwin, Michigan | Site Public Contact - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Gratiot Alma, Michigan | Site Public Contact - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Midland Midland, Michigan | Site Public Contact - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Mount Pleasant Mount Pleasant, Michigan | Site Public Contact - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Saginaw Saginaw, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| MyMichigan Medical Center Tawas Tawas City, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro, Arkansas | Site Public Contact - (Emily.Carvell@bmhcc.org) |
| New Ulm Medical Center New Ulm, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Newark Radiation Oncology Newark, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Newland Medical Associates-Clarkston Clarkston, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Newland Medical Associates-Pontiac Pontiac, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| North Grove Medical Park Spartanburg, South Carolina | |
| North Memorial Medical Health Center Robbinsdale, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| North Shore Medical Center Skokie, Illinois | Site Public Contact - (Roster@nrgoncology.org) |
| NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois | |
| NorthShore University HealthSystem-Glenbrook Hospital Glenview, Illinois | |
| NorthShore University HealthSystem-Highland Park Hospital Highland Park, Illinois | |
| Northwest Medical Specialties PLLC Tacoma, Washington | Site Public Contact - (research@southsoundcare.org) |
| Northwest Wisconsin Cancer Center Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Northwestern Medicine Cancer Center Delnor Geneva, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Cancer Center Kishwaukee DeKalb, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Glenview Outpatient Center Glenview, Illinois | |
| Northwestern Medicine Grayslake Outpatient Center Grayslake, Illinois | |
| Northwestern Medicine Lake Forest Hospital Lake Forest, Illinois | Site Public Contact - (cancertrials@northwestern.edu) |
| Northwestern Medicine Orland Park Orland Park, Illinois | Site Public Contact - (nctnprogram_rhlccc@northwestern.edu) |
| Northwestern University Chicago, Illinois | Site Public Contact - (cancer@northwestern.edu) |
| OSF Saint Anthony's Health Center Alton, Illinois | |
| Oakland Colon Rectal Associates Royal Oak, Michigan | |
| Oakland Medical Group Royal Oak, Michigan | |
| Ocean University Medical Center Brick, New Jersey | |
| Ohio State University Comprehensive Cancer Center Columbus, Ohio | Site Public Contact - (Jamesline@osumc.edu) |
| Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa | |
| Oncology Hematology Associates of Saginaw Valley PC Saginaw, Michigan | |
| Oncology Hematology Care Inc-Kenwood Cincinnati, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Orion Cancer Care Findlay, Ohio | |
| PROncology San Juan, | Site Public Contact - (info@PRoncology.com) |
| Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Pali Momi Medical Center ‘Aiea, Hawaii | |
| Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Parkland Health Center - Farmington Farmington, Missouri | |
| PeaceHealth Saint John Medical Center Longview, Washington | Site Public Contact - (kmakin-bond@peacehealth.org) |
| PeaceHealth Saint Joseph Medical Center Bellingham, Washington | Site Public Contact - (achapman1@peacehealth.org) |
| PeaceHealth United General Medical Center Sedro-Woolley, Washington | Site Public Contact - (achapman1@peacehealth.org) |
| Penn State Milton S Hershey Medical Center Hershey, Pennsylvania | Site Public Contact - (CTO@hmc.psu.edu) |
| Penrose-Saint Francis Healthcare Colorado Springs, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Phelps Health Delbert Day Cancer Institute Rolla, Missouri | Site Public Contact - (research@phelpshealth.org) |
| Physicians' Clinic of Iowa PC Cedar Rapids, Iowa | |
| Pocono Medical Center East Stroudsburg, Pennsylvania | Site Public Contact - (Morgan_M.Horton@lvhn.org) |
| Premier Hematology Oncology Care Sterling Heights, Michigan | |
| Presbyterian - Saint Lukes Medical Center - Health One Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Providence Alaska Medical Center Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Providence Cancer Institute Clackamas Clinic Clackamas, Oregon | |
| Providence Hood River Memorial Hospital Hood River, Oregon | Site Public Contact - (canrsrchstudies@provdience.org) |
| Providence Medical Foundation - Santa Rosa Santa Rosa, California | |
| Providence Newberg Medical Center Newberg, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Providence Portland Medical Center Portland, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Providence Queen of The Valley Napa, California | |
| Providence Regional Cancer Partnership Everett, Washington | Site Public Contact - (marilyn.birchman@providence.org) |
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| Providence Regional Cancer System-Lacey Lacey, Washington | Site Public Contact - (deidre.dillon@providence.org) |
| Providence Regional Cancer System-Shelton Shelton, Washington | |
| Providence Regional Cancer System-Yelm Yelm, Washington | |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank, California | Site Public Contact - (Najee.Boucher@providence.org) |
| Providence Saint Mary Regional Cancer Center Walla Walla, Washington | Site Public Contact - (Cheryl.Dodd@providence.org) |
| Providence Saint Vincent Medical Center Portland, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Providence Santa Rosa Memorial Hospital Santa Rosa, California | |
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| Puerto Rico Hematology Oncology Group Bayamón, | |
| Queen's Cancer Cenrer - POB I Honolulu, Hawaii | |
| Queen's Cancer Center - Kuakini Honolulu, Hawaii | |
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| SIH Cancer Institute Carterville, Illinois | Site Public Contact - (clinical.research@sih.net) |
| SMC Center for Hematology Oncology Union Union, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
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| Saint Claire Regional Medical Center Morehead, Kentucky | |
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| Saint Elizabeth Regional Medical Center Lincoln, Nebraska | |
| Saint Elizabeth Youngstown Hospital Youngstown, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
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| Saint Joseph Hospital Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Hospital Lexington, Kentucky | Site Public Contact - (carcieri@sjh-nh.org) |
| Saint Joseph Hospital East Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph London London, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Mount Sterling Mount Sterling, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Radiation Oncology Resource Center Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Warren Hospital Warren, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Saint Joseph's Hospital/Children's Hospital-Tampa Tampa, Florida | Site Public Contact - (jennifer.manns@baycare.org) |
| Saint Joseph's Medical Center Stockton, California | |
| Saint Luke's Cancer Institute - Boise Boise, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Fruitland Fruitland, Idaho | Site Public Contact - (eslinget@slhs.org) |
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| Saint Luke's Cancer Institute - Nampa Nampa, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Twin Falls Twin Falls, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Mary Corwin Medical Center Pueblo, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Mary's Hospital Centralia, Illinois | |
| Saint Mary's Oncology/Hematology Associates of Marlette Marlette, Michigan | |
| Saint Mary's Oncology/Hematology Associates of West Branch West Branch, Michigan | |
| Saint Michael Cancer Center Silverdale, Washington | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Patrick Hospital - Community Hospital Missoula, Montana | Site Public Contact - (amy.hanneman@providence.org) |
| Saint Peter's University Hospital New Brunswick, New Jersey | |
| Saint Rita's Medical Center Lima, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri | |
| Salem Hospital Salem, Massachusetts | |
| Salina Regional Health Center Salina, Kansas | Site Public Contact - (mleepers@srhc.com) |
| San Juan City Hospital San Juan, | |
| San Juan Community Oncology Group San Juan, | |
| Schulze Family Foundation Cancer Clinic - Bonita Health Center Bonita Springs, Florida | Site Public Contact - (RCCR@leehealth.org) |
| Shenandoah Oncology PC Winchester, Virginia | Site Public Contact - (William.Houck@usoncology.com) |
| Skagit Regional Health Cancer Care Center Mount Vernon, Washington | Site Public Contact - (rcccclinicalresearch@skagitvalleyhospital.org) |
| South Florida Baptist Hospital Plant City, Florida | Site Public Contact - (Claudia.Quinones@baycare.org) |
| South Sacramento Cancer Center Sacramento, California | Site Public Contact - (Kpoct@kp.org) |
| Southern Illinois University School of Medicine Springfield, Illinois | |
| Southern Ocean County Medical Center Manahawkin, New Jersey | |
| Southern Ohio Medical Center Portsmouth, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Spartanburg Medical Center Spartanburg, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
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| Springfield Regional Cancer Center Springfield, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
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| Stony Brook University Medical Center Stony Brook, New York | |
| Straub Clinic and Hospital Honolulu, Hawaii | |
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| Strecker Cancer Center-Belpre Belpre, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Summit Health - Florham Park Campus Florham Park, New Jersey | Site Public Contact - (mmackenzie@summithealth.com) |
| Summit Medical Group Berkeley Heights, New Jersey | Site Public Contact - (Roster@nrgoncology.org) |
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| Swedish Covenant Hospital Chicago, Illinois | |
| Swedish Medical Center-Ballard Campus Seattle, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Swedish Medical Center-Cherry Hill Seattle, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Swedish Medical Center-First Hill Seattle, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Tallahassee Memorial HealthCare Tallahassee, Florida | |
| Tamarack Health Hayward Medical Center Hayward, Wisconsin | |
| The Cancer Center of Hawaii-Liliha Honolulu, Hawaii | |
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| The Don and Sybil Harrington Cancer Center Amarillo, Texas | Site Public Contact - (Gina.Cravey@bsahs.org) |
| The Mark H Zangmeister Center Columbus, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| The Melanoma and Skin Cancer Institute Englewood, Colorado | Site Public Contact - (ryan.weight@theskincancerinstitute.com) |
| The Permanente Medical Group-Roseville Radiation Oncology Roseville, California | Site Public Contact - (Kpoct@kp.org) |
| The Philips Family Cancer Center Southampton, New York | |
| The Queen's Medical Center - West Oahu ‘Ewa Beach, Hawaii | Site Public Contact - (rohta@queens.org) |
| The University of Kansas Cancer Center - Olathe Olathe, Kansas | Site Public Contact - (OlatheCCResearch@kumc.edu) |
| The Women's Imaging Center Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| ThedaCare Cancer Care - Oshkosh Oshkosh, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| ThedaCare Cancer Care - Shawano Shawano, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| ThedaCare Cancer Care - Waupaca Waupaca, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| ThedaCare Regional Cancer Center Appleton, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| ThedaCare Regional Medical Center - Neenah Neenah, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| Tidelands Georgetown Memorial Hospital Georgetown, South Carolina | Site Public Contact - (broe@tidelandshealth.org) |
| Torrance Memorial Medical Center Torrance, California | |
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| TriHealth Cancer Institute-Anderson Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
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| Trinity Health Grand Rapids Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Trinity Health IHA - Obstetrics and Gynecology West Arbor Ann Arbor, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology - Canton Canton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Medical Center - Brighton Brighton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Medical Center - Canton Canton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Muskegon Hospital Muskegon, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Medical Center Moline, Illinois | |
| Tufts Medical Center Boston, Massachusetts | Site Public Contact - (ContactUsCancerCenter@TuftsMedicalCenter.org) |
| Tufts Medical Center Cancer Center Stoneham Stoneham, Massachusetts | Site Public Contact - (NCCCR@Tuftsmedicalcenter.org) |
| UCLA / Jonsson Comprehensive Cancer Center Los Angeles, California | |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny, Iowa | |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines, Iowa | |
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| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa | |
| UI Healthcare Mission Cancer and Blood - Fort Dodge Fort Dodge, Iowa | Site Public Contact - (trials@missioncancer.com) |
| UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie, Maryland | |
| UP Health System Hematology Oncology Marquette Marquette, Michigan | Site Public Contact - (Dianna.Larson@mghs.org) |
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| UPMC Cancer Center at UPMC Horizon Farrell, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
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| University Health Truman Medical Center Kansas City, Missouri | |
| University of Cincinnati Cancer Center-UC Medical Center Cincinnati, Ohio | Site Public Contact - (cancer@uchealth.com) |
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| University of Hawaii Cancer Center Honolulu, Hawaii | |
| University of Iowa Healthcare Cancer Services Quad Cities Bettendorf, Iowa | Site Public Contact - (katherine-daprile@uiowa.edu) |
| University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa | |
| University of Kansas Cancer Center Kansas City, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
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| University of Kansas Cancer Center - Lee's Summit Lee's Summit, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center - North Kansas City, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center at North Kansas City Hospital North Kansas City, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center-Overland Park Overland Park, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
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| University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Maryland Shore Medical Center at Easton Easton, Maryland | Site Public Contact - (Christina.weisenborn@umm.edu) |
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| University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma | Site Public Contact - (ou-clinical-trials@ouhsc.edu) |
| University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania | |
| University of Texas Medical Branch Galveston, Texas | Site Public Contact - (clinical.research@utmb.edu) |
| VCU Community Memorial Health Center South Hill, Virginia | Site Public Contact - (nemer.elmouallem@vcuhealth.org) |
| VCU Massey Cancer Center at Stony Point Richmond, Virginia | Site Public Contact - (ctoclinops@vcu.edu) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| Valley Radiation Oncology Peru, Illinois | |
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| Wayne Hospital Greenville, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| West Michigan Cancer Center Kalamazoo, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
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| Woodland Memorial Hospital Woodland, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Wright-Patterson Medical Center Wright-Patterson Air Force Base, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Zangmeister Center Grove City Grove City, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
Advancing Water Security: A Community Participatory School-Based Hydration Intervention
Sarah Farthing, MS - sarah.malone@vcuhealth.org
Melanie Bean
NCT06714929
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Lunchroom observations: All students (K-5th \[Pre-Kindergarten if applicable\]) who eat lunch in the cafeteria on assessment days are eligible
* BMI and dental caries assessments: 1) student enrolls in study while in 3rd grade (followed through 5th g)
* Student surveys: Students in 4th-5th grade are eligible to complete surveys assessing beverage intake and perceptions of hydration practices within their school district.
* Staff surveys: All staff in the target schools will be eligible to complete the Personnel Survey.
Exclusion Criteria:
* Lunchroom observations: None.
* BMI and dental caries assessments: Students are ineligible if they are unable to complete assessments due to developmental or physical reasons, 2) planning to move in the study duration
* Student surveys: None.
* Staff surveys: None. BEHAVIORAL: Hydration
Dental Caries, Obesity Prevention
hydration, water, sugar-sweetened beverages, dental caries, overweight and obesity
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Study Locations
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| Location | Contacts |
|---|---|
| Children's Hospital of Richmond at VCU Healthy Lifestyles Center Henrico, Virginia | Sarah M Farthing, MS - (sarah.malone@vcuhealth.org) Melanie K Bean, PhD - (melanie.bean@vcuhealth.org) |
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy (REBIRTH)
Dennis McNamara, MD - mcnamaradm@upmc.edu
NCT05180773
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Inclusion Criteria:
• Presentation with a new diagnosis of peripartum cardiomyopathy
• Post-delivery and within the first 5 months post-partum.
• Clinical assessment of an LVEF \< or =0.40 within 4 weeks of consent for randomized control trial
• Clinical assessment of an LVEF \< or =0.40 within 8 weeks of consent for breastfeeding cohort
• Age \> or = 18.
Exclusion Criteria:
• Previous diagnosis of cardiomyopathy, valvular disease or congenital heart disease (with the exception of women with a history of peripartum cardiomyopathy with complete recovery and a documented LVEF \> 0.55 prior to or in early pregnancy)
• Refractory hypertension (Systolic \>160 or Diastolic \> 95) either at the time of enrollment or at the time of the qualifying LVEF.
• Postpartum women currently breastfeeding and planning to continue.
• Evidence of coronary artery disease (\>50% stenosis of major epicardial vessel or positive non-invasive stress test)
• Previous cardiac transplant
• Current durable LVAD support
• Currently requiring support with extracorporeal membrane oxygenation (ECMO)
• Current history of alcohol or drug abuse
• Chemotherapy or chest radiation within 5 years of enrollment
• Evidence of ongoing bacterial septicemia
• Medical, social or psychiatric condition which limit the ability to comply with follow-up.
DRUG: Bromocriptine, DRUG: Placebo, DRUG: Guideline Directed Medical Therapy for Heart Failure (GDMT), DRUG: Rivaroxaban, DRUG: Second Placebo
Peripartum Cardiomyopathy, Postpartum
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Show 64 locations
Study Locations
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| Location | Contacts |
|---|---|
| Albert Einstein College of Medicine/ Montefiore Medical Center The Bronx, New York | Vanya Prasad - (vprasad@montefiore.org) |
| Ascension St. Vincent Heart Center Indianapolis, Indiana | Anne Renick - (anne.renick@ascension.org) Regina Margiotti - (RAMARGIO@ascension.org) |
| Atrium Health Sanger Heart and Vascular Institute Charlotte, North Carolina | Zaida Roman - (Zaida.roman@atriumhealth.org) |
| Baylor College of Medicine Houston, Texas | Sandra Pena - (sandra.pena@bcm.edu) |
| Brigham and Women's Hospital Boston, Massachusetts | Audrey Yun - (ayun1@bwh.harvard.edu) Mariam Markabani - (mmarkabani@bwh.harvard.edu) |
| Cedars-Sinai Medical Center Los Angeles, California | Odette Chida Ibarra - (odette.chidaibarra@cshs.org) |
| Cleveland Clinic Cleveland, Ohio | Barbara Gus - (gusb@ccf.org) |
| Columbia University Irving Medical Center New York, New York | Barbara Alvarez - (bsa2133@cumc.columbia.edu) |
| Emory University Atlanta, Georgia | Eisha Udeshi - (eudeshi@emory.edu) Nino Kavtaradze - (nkavtar@emory.edu) |
| Hartford Hospital Hartford, Connecticut | Khadija El Aoudi - (Khadija.ElAoudi@hhchealth.org) |
| Henry Ford Health System Detroit, Michigan | Jodi Carter - (jcarte23@hfhs.org) |
| Indiana University/Indiana University Health Indianapolis, Indiana | Srdjan Kurbalija - (skurbalija@iuhealth.org) |
| Inova Healthcare Services Fairfax, Virginia | Joanne Wotring - (joanne.wotring@inova.org) |
| Intermountain Medical Center Murray, Utah | Morgan McClure - (morgan.mcclure@imail.org) |
| Johns Hopkins University Baltimore, Maryland | Yavette Goldsborough - (ygoldsb1@jhmi.edu) |
| Karen L Florio, MD Columbia, Missouri | Akira Clemons - (amcg5z@umsystem.edu) |
| Keck School of Medicine of USC Los Angeles, California | Jorge Caro - (jorge.caro@med.usc.edu) |
| Lehigh Valley Health Network Allentown, Pennsylvania | |
| Louisiana State University Shreveport, Louisiana | Monicah Jepkemboi - (monicah.jepkemboi@lsuhs.edu) |
| Massachusetts General Hospital Boston, Massachusetts | Monica Duan - (mduan2@mgb.org) |
| Mayo Clinic, Florida Jacksonville, Florida | Jena Hayes - (hayes.jena@mayo.edu) |
| Mayo Clinic, Rochester Rochester, Minnesota | Molly Dolan - (Dolan.Molly@mayo.edu) Brittni Ferdinand - (Ferdinand.brittni@mayo.edu) |
| Medical College of Wisconsin Milwaukee, Wisconsin | Amy Blair - (ablair@mcw.edu) |
| Medical University of South Carolina Charleston, South Carolina | Virginia Theodorof - (theodoro@musc.edu) Olivia Washington - (washoliv@musc.edu) |
| Minneapolis Heart Institute Foundation Minneapolis, Minnesota | Sarah Schwager - (Sarah.Schwager@allina.com) Gretchen Benson - (GBenson@mhif.org) |
| Mount Sinai Hospital New York, New York | Lovelyne Julien - (lovelyn.julien@mountsinai.org) Tiffany Soto - (tiffany.soto@mssm.edu) |
| NYU Langone Health New York, New York | Lucia Muzzarelli - (Lucia.Muzzarelli@nyulangone.org) |
| Northwestern University Chicago, Illinois | Jessica Patalino - (jessica.patalino@nm.org) |
| Oklahoma University Health Science Center Oklahoma City, Oklahoma | Natalie Feland - (natalie-feland@ouhsc.edu) |
| Old Dominion University Norfolk, Virginia | Kristin Ayers - (ayerskl@evms.edu) |
| Penn State Hershey Medical Center Hershey, Pennsylvania | Katie Loffredo - (kloffredo@pennstatehealth.psu.edu) Veronica Bausher - (vbausher@pennstatehealth.psu.edu) |
| Rhode Island Hospital Providence, Rhode Island | Kelly Franchetti, RN - (kfranchetti@lifespan.org) |
| Saint Luke's Hospital of Kansas City Kansas City, Missouri | Rosann Gans, RN - (rgans@saint-lukes.org) |
| Stanford University Palo Alto, California | Tamara Bazouzi - (bazouzit@stanford.edu) |
| Stern Cardiovascular Foundation, Inc Germantown, Tennessee | Denise Peeler - (denise.peeler@sterncardio.com) Kari Fondren - (kari.fondren@sterncardio.com) |
| Stony Brook Medicine Stony Brook, New York | Uzma Usmani - (Uzma.Usmani@stonybrookmedicine.edu) |
| Temple Heart and Vascular Institute Philadelphia, Pennsylvania | Jennie Wong - (jennie.wong@tuhs.temple.edu) |
| UT Southern Medical Center Dallas, Texas | |
| University Hospitals, Cleveland Medical Center Cleveland, Ohio | Emily Mullenax - (Emily.Mullenax@UHhospitals.org) |
| University of Alabama Birmingham Birmingham, Alabama | LaTangellia Walker - (latangelliadwalker@uabmc.edu) Nancy Saxon - (nbsaxon@uabmc.edu) |
| University of Arizona Sarver Heart Center Tucson, Arizona | Lizzette Cruz - (marquez@shc.arizona.edu) |
| University of California Irvine Health Orange, California | Linh Huỳnh, MPH - (plhuynh@hs.uci.edu) |
| University of California San Diego La Jolla, California | Rachel Han - (rah015@health.ucsd.edu) |
| University of Colorado Anschutz Medical Campus Aurora, Colorado | Jamie Demmitt, BA - (jamie.demmitt@cuanschutz.edu) |
| University of Florida Gainesville, Florida | David Solares - (David.Solares@medicine.ufl.edu) Vanessa Holway Scheuble - (Vanessa.Scheuble@medicine.ufl.edu) |
| University of Illinois Health Heart Center Chicago, Illinois | Muriel Chen - (yining@uic.edu) |
| University of Iowa Hospitals and Clinic Iowa City, Iowa | Cynthia Larew - (cynthia-larew@uiowa.edu) Page Scovel - (page-scovel@uiowa.edu) |
| University of Kentucky, Gill Heart & Vascular Institute Lexington, Kentucky | Jennifer Isaacs - (Jennifer.isaacs@uky.edu) Travis Sexton - (trsext2@uky.edu) |
| University of Maryland Medical Center, Baltimore Baltimore, Maryland | Caitlin Hearn - (chearn@som.umaryland.edu) |
| University of Michigan Ann Arbor, Michigan | Kavita Shah - (skavita@med.umich.edu) |
| University of Minnesota Minneapolis, Minnesota | Melanie Farinella - (crawl027@umn.edu) |
| University of Pennsylvania Philadelphia, Pennsylvania | Alavi Hossain - (Alavi.Hossain@Pennmedicine.upenn.edu) |
| University of Pittsburgh Medical Center Pittsburgh, Pennsylvania | Dennis McNamara, MD - (mcnamaradm@upmc.edu) Donna Simpson, CRNP, MPH - (simpsondm@upmc.edu) |
| University of Rochester Rochester, New York | Lori Caufield, RN BSN CCRC - (lori_caufield@urmc.rochester.edu) |
| University of South Florida Tampa, Florida | Amanda McNamara - (alett1@usf.edu) Jacky He - (jackyhe@usf.edu) |
| University of Texas Health San Antonio San Antonio, Texas | |
| University of Vermont Medical Center Burlington, Vermont | Meghan Sesera, RN - (meghan.sesera@uvmhealth.org) Michaelanne Rowen - (Michaelanne.Rowen@uvmhealth.org) |
| University of Virginia Charlottesville, Virginia | Melanie Dean - (DMD4PD@uvahealth.org) Caroline Flournoy - (clf4w@uvahealth.org) |
| University of Washington Medical Center Seattle, Washington | Adele Stefanowicz - (amstef99@cardiology.washington.edu) |
| University of Wisconsin Madison Madison, Wisconsin | Holly Hage - (hhage@wisc.edu) Karen Olson - (kjolson@medicine.wisc.edu) |
| Vanderbilt Nashville, Tennessee | Olivia Patridge - (olivia.h.patridge@vumc.org) |
| Virginia Commonwealth University Henrico, Virginia | Melissa Sears - (melissa.sears@vcuhealth.org) |
| Washington University School of Medicine St Louis, Missouri | Annie Dirks - (aplatts@wustl.edu) Lesley Alexander - (alesley@wustl.edu) |
| Yale University New Haven, Connecticut | Cinthia S De Freitas - (cinthia.defreitas@yale.edu) |
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps (FORTE)
Director, Department of Regulatory Affairs - langerj@nrgoncology.org
NCT05080673
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Inclusion Criteria:
* The participant must have signed and dated an IRB-approved consent form that conforms to federal and institutional guidelines.
* Participants greater than or equal to 45 and less than 70 years of age at the time of colonoscopy.
* Participants with a first-time diagnosis of 1-2 non-advanced tubular adenomas (less than 10 mm without tubulovillous or villous changes or high grade or severe dysplasia) from the qualifying colonoscopy within 4 years prior to randomization.
* Sessile serrated polyps/adenomas, as long as they do not meet the criteria for advanced adenomas, will be considered as non-advanced adenomas.
* Qualifying colonoscopy must be a complete colonoscopy with visualization of the cecum and with adequate cleansing within 4 years prior to randomization.
* Complete excision of all observed polyps in qualifying colonoscopy
* Participants must be able to read or understand English or Spanish.
Exclusion Criteria:
* • Prior history of colorectal cancer or colorectal adenomas including sessile serrated polyps/adenomas excluding those found on the qualifying colonoscopy.
* Prior history of a hyperplastic polyp measuring greater than or equal to 1 cm in size.
* Traditional serrated adenomas found on the qualifying colonoscopy.
* Hyperplastic polyp measuring greater than or equal to 1 cm in size found on the qualifying colonoscopy.
* Previous malignancies unless the patient has been disease-free for 5 or more years prior to randomization and is deemed by the physician to be at low risk for recurrence. Patients with the following cancers are eligible if diagnosed and treated within the past 5 years: all in situ cancers and basal cell and squamous cell carcinoma of the skin.
* Colonoscopy performed after the qualifying colonoscopy but prior to randomization.
* Incomplete qualifying colonoscopy (e.g., cecum not visualized).
* Incomplete endoscopic excision of adenomatous polyps based on colonoscopist impression at qualifying colonoscopy. (Excision of all hyperplastic rectosigmoid polyps is not required.)
* Sub-total colectomy or total proctocolectomy. (Segmental resections are allowed.)
* Family history of CRC diagnosed at less than or equal to 60 years of age in a first degree relative (mother, father, child, sibling) or in two first degree relatives with CRC at any age.
* Participants with a clinical diagnosis of a significant heritable risk for colorectal cancer (Familial Adenomatous Polyposis, Hereditary Nonpolyposis Colorectal Cancer \[Lynch Syndrome\]).
* Participants tested positive for a Familial Adenomatous Polyposis, Hereditary Nonpolyposis Colorectal Cancer \[Lynch Syndrome\] genetic mutation that increases risk of colorectal cancer.
* Inflammatory bowel disease (e.g., Crohn's Disease, ulcerative colitis).
* Life expectancy less than 10 years due to comorbid conditions in the opinion of the investigator.
* Other comorbid conditions that would prevent the participant from having colonoscopies or would prevent required follow-up. PROCEDURE: 5-year and 10 Year Surveillance Colonoscopy after Qualifying Colonoscopy
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
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Show 486 locations
Study Locations
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| Location | Contacts |
|---|---|
| Abbott-Northwestern Hospital Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| AdventHealth Littleton Littleton, Colorado | |
| AdventHealth Parker Parker, Colorado | |
| AdventHealth Porter Denver, Colorado | |
| Alegent Health Bergan Mercy Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Immanuel Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Lakeside Hospital Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Mercy Hospital Council Bluffs, Iowa | |
| Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Alta Bates Summit Medical Center - Summit Campus Oakland, California | |
| Altru Cancer Center Grand Forks, North Dakota | |
| Ann M Wierman MD LTD Las Vegas, Nevada | |
| Armes Family Cancer Center Findlay, Ohio | |
| Ascension All Saints Hospital Racine, Wisconsin | |
| Ascension Calumet Hospital Chilton, Wisconsin | |
| Ascension Columbia Saint Mary's Hospital - Milwaukee Milwaukee, Wisconsin | |
| Ascension Columbia Saint Mary's Hospital Ozaukee Mequon, Wisconsin | |
| Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa, Wisconsin | |
| Ascension Mercy Hospital Oshkosh, Wisconsin | |
| Ascension Saint Elizabeth Hospital Appleton, Wisconsin | |
| Ascension Saint Francis - Reiman Cancer Center Franklin, Wisconsin | |
| Ascension Saint Francis Hospital Milwaukee, Wisconsin | |
| Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield, Wisconsin | |
| Ascension Southeast Wisconsin Hospital - Franklin Franklin, Wisconsin | |
| Ascension Southeast Wisconsin Hospital - Saint Joseph Campus Milwaukee, Wisconsin | |
| Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Audie L Murphy VA Hospital San Antonio, Texas | |
| Augusta University Medical Center Augusta, Georgia | Site Public Contact - (ga_cares@augusta.edu) |
| BASS Medical Group - Lennon Walnut Creek, California | Site Public Contact - (brenna.lindsey@bassmedicalgroup.com) |
| Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Bay Area Breast Surgeons Inc Emeryville, California | |
| Bay Area Tumor Institute Oakland, California | |
| Bay Pines VA Healthcare System Bay Pines, Florida | Site Public Contact - (vhabayresearch@va.gov) |
| Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston, Texas | |
| Beacon Kalamazoo Kalamazoo, Michigan | |
| Beacon Kalamazoo Cancer Center Kalamazoo, Michigan | |
| Beaufort Memorial Hospital Beaufort, South Carolina | Site Public Contact - (kwade@bmhsc.org) |
| Benefis Helena Specialty Center Helena, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Benefis Sletten Cancer Institute Great Falls, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Bethesda North Hospital Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Billings Clinic Cancer Center Billings, Montana | Site Public Contact - (research@billingsclinic.org) |
| Billings Clinic-Cody Cody, Wyoming | Site Public Contact - (research@billingsclinic.org) |
| Blanchard Valley Hospital Findlay, Ohio | |
| Boston Veteran's Affairs Medical Center Jamaica Plain, Massachusetts | Site Public Contact - (ctsucontact@westat.com) |
| Boulder Community Foothills Hospital Boulder, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Bozeman Health Deaconess Hospital Bozeman, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Bronson Battle Creek Battle Creek, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Bronson Methodist Hospital Kalamazoo, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| CARTI Cancer center Little Rock, Arkansas | Site Public Contact - (Research@CARTI.com) |
| CHI Health Good Samaritan Kearney, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| CHI Health Saint Francis Grand Island, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| CHI Saint Vincent Cancer Center Hot Springs Hot Springs, Arkansas | |
| CTCA at Western Regional Medical Center Goodyear, Arizona | |
| Cambridge Medical Center Cambridge, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Camden Clark Medical Center Parkersburg, West Virginia | Site Public Contact - (cancertrialsinfo@hsc.wvu.edu) |
| Cancer Center at Saint Joseph's Phoenix, Arizona | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Cancer Center of Western Wisconsin New Richmond, Wisconsin | Site Public Contact - (mmcorc@healthpartners.com) |
| Cancer Center-Metro Medical Center Bayamon Bayamón, | |
| Cancer and Blood Specialists-Henderson Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan | Site Public Contact - (connie.szczepanek@crcwm.org) |
| Carilion Roanoke Memorial Hospital Roanoke, Virginia | |
| Carle Cancer Center Urbana, Illinois | |
| Carle Physician Group-Effingham Effingham, Illinois | |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | |
| Carle at The Riverfront Danville, Illinois | |
| Carson Tahoe Regional Medical Center Carson City, Nevada | Site Public Contact - (research@sncrf.org) |
| Case Western Reserve University Cleveland, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| Central Care Cancer Center - Bolivar Bolivar, Missouri | Site Public Contact - (aroland@kccop.org) |
| Central Care Cancer Center - Garden City Garden City, Kansas | Site Public Contact - (aroland@kccop.org) |
| Central Care Cancer Center - Great Bend Great Bend, Kansas | Site Public Contact - (aroland@kccop.org) |
| Centro Comprensivo de Cancer de UPR San Juan, | Site Public Contact - (Roster@nrgoncology.org) |
| Colorado Blood Cancer Institute Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| CommonSpirit Cancer Center Mercy Durango, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| CommonSpirit Saint Anthony Hospital Cancer Center Lakewood, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Commonwealth Cancer Center-Corbin Corbin, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Community Hospital of Anaconda Anaconda, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Community Medical Center Missoula, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Community Medical Center Missoula, Montana | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Comprehensive Cancer Centers of Nevada Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada - Henderson Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada - Northwest Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada - Town Center Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Contra Costa Regional Medical Center Martinez, California | |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Lakeland Hospitals - Niles Hospital Niles, Michigan | |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Reed City Hospital Reed City, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Cotton O'Neil Cancer Center / Stormont Vail Health Topeka, Kansas | |
| Cox Cancer Center Branson Branson, Missouri | |
| CoxHealth South Hospital Springfield, Missouri | |
| Creighton University Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Dayton Physician LLC - Englewood Dayton, Ohio | |
| Dayton Physicians LLC - Troy Troy, Ohio | |
| Dayton Physicians LLC-Atrium Franklin, Ohio | |
| Dayton Physicians LLC-Miami Valley South Centerville, Ohio | |
| Dayton Physicians LLC-Wayne Greenville, Ohio | |
| Doctors Cancer Center Manati, | |
| Duluth Clinic Ashland Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Epic Care Cyberknife Center Walnut Creek, California | |
| Epic Care Partners in Cancer Care Emeryville, California | |
| Epic Care-Dublin Dublin, California | |
| Essentia Health - Baxter Clinic Baxter, Minnesota | |
| Essentia Health - Deer River Clinic Deer River, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Ely Clinic Ely, Minnesota | |
| Essentia Health - Fosston Fosston, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - International Falls Clinic International Falls, Minnesota | |
| Essentia Health - Jamestown Clinic Jamestown, North Dakota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Moose Lake Clinic Moose Lake, Minnesota | |
| Essentia Health - Park Rapids Park Rapids, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Saint Joseph's Crosslake Clinic Crosslake, Minnesota | |
| Essentia Health - Saint Joseph's Pequot Lakes Clinic Pequot Lakes, Minnesota | |
| Essentia Health - Saint Joseph's Pine River Clinic Pine River, Minnesota | |
| Essentia Health - Saint Joseph's Staples Clinic Staples, Minnesota | |
| Essentia Health Cancer Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center-South University Clinic Fargo, North Dakota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Hibbing Clinic Hibbing, Minnesota | |
| Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Saint Mary's Hospital - Superior Superior, Wisconsin | |
| Essentia Health Saint Mary's Medical Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Sandstone Sandstone, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Virginia Clinic Virginia, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Hayward Clinic Hayward, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Spooner Clinic Spooner, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Fairbanks Memorial Hospital Fairbanks, Alaska | |
| Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Lakes Medical Center Wyoming, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Northland Medical Center Princeton, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Ridges Hospital Burnsville, Minnesota | |
| Fairview Southdale Hospital Edina, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Flaget Memorial Hospital Bardstown, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Franciscan Research Center-Northwest Medical Plaza Tacoma, Washington | |
| Freeman Health System Joplin, Missouri | Site Public Contact - (LJCrockett@freemanhealth.com) |
| Gastro Health - Galloway Miami, Florida | Site Public Contact - (jleavitt@gastrohealth.com) |
| Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center Danville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| George E Wahlen Department of Veterans Affairs Medical Center Salt Lake City, Utah | |
| George Washington University Medical Center Washington D.C., District of Columbia | |
| Gibbs Cancer Center-Gaffney Gaffney, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Gibbs Cancer Center-Pelham Greer, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Good Samaritan Hospital - Cincinnati Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Great Falls Clinic Great Falls, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Greater Dayton Cancer Center Kettering, Ohio | |
| Greater Regional Medical Center Creston, Iowa | |
| HIMA San Pablo Oncologic Hospital Caguas, | |
| Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii | |
| Health Partners Inc Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Heartland Regional Medical Center Saint Joseph, Missouri | Site Public Contact - (Trisha.England2@mymlc.com) |
| Hennepin County Medical Center Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Hi-Line Sletten Cancer Center Havre, Montana | Site Public Contact - (Roster@nrgoncology.org) |
| Highline Medical Center-Main Campus Burien, Washington | |
| Hope Cancer Care of Nevada Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Hope Cancer Care of Nevada-Pahrump Pahrump, Nevada | Site Public Contact - (research@sncrf.org) |
| Idaho Urologic Institute-Meridian Meridian, Idaho | |
| Indu and Raj Soin Medical Center Beavercreek, Ohio | |
| Instituto Oncologia Moderna Ponce Ponce, | |
| Jefferson Healthcare Port Townsend, Washington | |
| Jewish Hospital Louisville, Kentucky | |
| Jewish Hospital Medical Center South Shepherdsville, Kentucky | |
| John H Stroger Jr Hospital of Cook County Chicago, Illinois | |
| Kaiser Permanente - Kensington Medical Center Kensington, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente - Largo Medical Center Largo, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente - Panorama City Panorama City, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente Los Angeles Medical Center Los Angeles, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente Lutherville - Timonium Medical Center Lutherville, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente South Bay Harbor City, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente Tysons Corner Medical Center McLean, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente West Los Angeles Los Angeles, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Anaheim Anaheim, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Baldwin Park Baldwin Park, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Bellflower Bellflower, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Burke Medical Center Burke, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Capitol Hill Medical Center Washington D.C., District of Columbia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Caton Hill Medical Center Woodbridge, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Fontana Fontana, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Franklin Denver, Colorado | Site Public Contact - (KPCOIHRClinicalResearch@kp.org) |
| Kaiser Permanente-Gaithersburg Medical Center Gaithersburg, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Irvine Irvine, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Lone Tree Lone Tree, Colorado | Site Public Contact - (KPCOIHRClinicalResearch@kp.org) |
| Kaiser Permanente-Ontario Ontario, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Riverside Riverside, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Rock Creek Lafayette, Colorado | Site Public Contact - (KPCOIHRClinicalResearch@kp.org) |
| Kaiser Permanente-San Diego Mission San Diego, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-San Diego Zion San Diego, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-San Marcos San Marcos, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Vallejo Vallejo, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Woodland Hills Woodland Hills, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Woodlawn Medical Center Baltimore, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kansas City Veterans Affairs Medical Center Kansas City, Missouri | |
| Kapiolani Medical Center for Women and Children Honolulu, Hawaii | |
| Kettering Medical Center Kettering, Ohio | |
| Kingman Regional Medical Center Kingman, Arizona | Site Public Contact - (research@sncrf.org) |
| Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Kuakini Medical Center Honolulu, Hawaii | |
| LSU Health Sciences Center at Shreveport Shreveport, Louisiana | Site Public Contact - (LPost@lsuhsc.edu) |
| Labette Health Parsons, Kansas | |
| Lake Region Healthcare Corporation-Cancer Care Fergus Falls, Minnesota | |
| Lake Regional Hospital Osage Beach, Missouri | Site Public Contact - (clinicaltrials@lakeregional.com) |
| Lakeview Hospital Stillwater, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Las Vegas Prostate Cancer Center Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Las Vegas Urology - Cathedral Rock Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Las Vegas Urology - Green Valley Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Las Vegas Urology - Pebble Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Las Vegas Urology - Pecos Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Las Vegas Urology - Smoke Ranch Las Vegas, Nevada | Site Public Contact - (research@smcrf.org) |
| Las Vegas Urology - Sunset Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York | Site Public Contact - (CancerTrials@nyulangone.org) |
| Logan Health Medical Center Kalispell, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Longmont United Hospital Longmont, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Louis Stokes Cleveland VA Medical Center Cleveland, Ohio | Site Public Contact - (holly.henry@va.gov) |
| Louisiana State University Health Science Center New Orleans, Louisiana | Site Public Contact - (emede1@lsuhsc.edu) |
| Lovelace Medical Center-Saint Joseph Square Albuquerque, New Mexico | |
| Low Country Cancer Care Savannah, Georgia | Site Public Contact - (Lorraine.OHara@hcahealthcare.com) |
| Loyola University Medical Center Maywood, Illinois | |
| MaineHealth Maine Medical Center- Scarborough Scarborough, Maine | Site Public Contact - (clinicalresearch@mainehealth.org) |
| Malcom Randall Veterans Administration Medical Center Gainesville, Florida | Site Public Contact - (trials@cancer.ufl.edu) |
| Marshfield Clinic-Wausau Center Wausau, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center - Minocqua Minocqua, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center - Weston Weston, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-Marshfield Marshfield, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Massachusetts General Hospital Cancer Center Boston, Massachusetts | |
| Mayo Clinic in Rochester Rochester, Minnesota | |
| MedStar Georgetown University Hospital Washington D.C., District of Columbia | |
| Medical University of South Carolina Charleston, South Carolina | Site Public Contact - (hcc-clinical-trials@musc.edu) |
| Memorial Health University Medical Center Savannah, Georgia | Site Public Contact - (Lorraine.OHara@hcahealthcare.com) |
| Memorial Hospital of Laramie County Cheyenne, Wyoming | Site Public Contact - (Roster@nrgoncology.org) |
| Mercy Cancer Center Merced, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Cape Girardeau Cape Girardeau, Missouri | |
| Mercy Cancer Center - Carmichael Carmichael, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Elk Grove Elk Grove, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Rocklin Rocklin, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Sacramento Sacramento, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center-West Lakes Clive, Iowa | |
| Mercy Clinic-Rolla-Cancer and Hematology Rolla, Missouri | |
| Mercy Health - Paducah Cancer Center Paducah, Kentucky | Site Public Contact - (BJWarner@mercy.com) |
| Mercy Hospital Coon Rapids, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mercy Hospital Fort Smith Fort Smith, Arkansas | |
| Mercy Hospital Joplin Joplin, Missouri | Site Public Contact - (esmeralda.carrillo@mercy.net) |
| Mercy Hospital Oklahoma City Oklahoma City, Oklahoma | |
| Mercy Hospital Pittsburg Pittsburg, Kansas | |
| Mercy Hospital Saint Louis St Louis, Missouri | |
| Mercy Hospital South St Louis, Missouri | Site Public Contact - (Danielle.Werle@mercy.net) |
| Mercy Hospital Springfield Springfield, Missouri | |
| Mercy Hospital Washington Washington, Missouri | |
| Mercy Infusion Center - Chippewa St Louis, Missouri | |
| Mercy Medical Center Springfield, Massachusetts | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Medical Center - Des Moines Des Moines, Iowa | |
| Mercy Medical Center-West Lakes West Des Moines, Iowa | |
| Mercy Oncology and Hematology - Clayton-Clarkson Ballwin, Missouri | |
| Mercy San Juan Medical Center Carmichael, California | Site Public Contact - (ResearchInstituteInquiries@commonspirit.org) |
| Mercyhealth Cancer Institute - Rockford Rockford, Illinois | Site Public Contact - (oncologyclinicaltrials@mhemail.org) |
| Mercyhealth Hospital and Cancer Center - Janesville Janesville, Wisconsin | Site Public Contact - (oncologyclinicaltrials@mhemail.org) |
| Miami Valley Cancer Care and Infusion Greenville, Ohio | |
| Miami Valley Hospital Dayton, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Miami Valley Hospital North Dayton, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Miami Valley Hospital South Centerville, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Midlands Community Hospital Papillion, Nebraska | |
| Midwestern Regional Medical Center Zion, Illinois | |
| Miller-Dwan Hospital Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Minneapolis VA Medical Center Minneapolis, Minnesota | |
| Minnesota Oncology - Burnsville Burnsville, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology - Coon Rapids Coon Rapids, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology - Edina Edina, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology - Maple Grove Maple Grove, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Chaska Chaska, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mission Hope Medical Oncology - Santa Maria Santa Maria, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Monticello Cancer Center Monticello, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Morristown Medical Center Morristown, New Jersey | |
| Mount Sinai Comprehensive Cancer Center at Aventura Aventura, Florida | Site Public Contact - (yenrique@msmc.com) |
| Mount Sinai Medical Center Miami Beach, Florida | Site Public Contact - (Yvonne.Enriquez@msmc.com) |
| Mountain Blue Cancer Care Center - Swedish Englewood, Colorado | |
| Munson Medical Center Traverse City, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York, New York | Site Public Contact - (cancerclinicaltrials@cumc.columbia.edu) |
| Nebraska Cancer Specialists/Oncology Hematology West PC Grand Island, Nebraska | |
| New Ulm Medical Center New Ulm, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| North Grove Medical Park Spartanburg, South Carolina | |
| North Memorial Medical Health Center Robbinsdale, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima, Washington | Site Public Contact - (Memorial-ClinicalTrials@yvmh.org) |
| Northwest Cancer Center - Crown Point Crown Point, Indiana | Site Public Contact - (CancerResearch@powershealth.org) |
| Northwest Cancer Center - Hobart Hobart, Indiana | |
| Northwest Cancer Center - Valparaiso Valparaiso, Indiana | Site Public Contact - (CancerResearch@COMHS.org) |
| Northwest Oncology LLC Dyer, Indiana | |
| Northwest Wisconsin Cancer Center Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Northwestern University Chicago, Illinois | |
| OSF Saint Anthony's Health Center Alton, Illinois | |
| Ohio State University Comprehensive Cancer Center Columbus, Ohio | Site Public Contact - (Jamesline@osumc.edu) |
| Oncology Hematology Care Inc-Kenwood Cincinnati, Ohio | |
| Oncology Las Vegas - Henderson Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Oncology Las Vegas - Tenaya Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| OptumCare Cancer Care at Charleston Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| OptumCare Cancer Care at Fort Apache Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| OptumCare Cancer Care at MountainView Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Oregon Health and Science University Portland, Oregon | Site Public Contact - (trials@ohsu.edu) |
| Orion Cancer Care Findlay, Ohio | |
| PCR Oncology Arroyo Grande, California | Site Public Contact - (research@sncrf.org) |
| PROncology San Juan, | Site Public Contact - (info@PRoncology.com) |
| Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Pali Momi Medical Center ‘Aiea, Hawaii | |
| Pan American Center for Oncology Trials LLC San Juan, | Site Public Contact - (marcia.cruzcorrea@panoncologytrials.com) |
| Pan American Center for Oncology Trials LLC - Ciudadela San Juan, | Site Public Contact - (info@panoncologytrials.com) |
| Pan American Center for Oncology Trials LLC - Dorado Dorado, | Site Public Contact - (info@panoncologytrials.com) |
| Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Penrose-Saint Francis Healthcare Colorado Springs, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Phelps Health Delbert Day Cancer Institute Rolla, Missouri | Site Public Contact - (research@phelpshealth.org) |
| Piedmont Hospital Atlanta, Georgia | |
| Portland VA Medical Center Portland, Oregon | |
| Premier Blood and Cancer Center Dayton, Ohio | |
| Presbyterian - Saint Lukes Medical Center - Health One Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Primary Care Physician Group San Juan, | |
| Princeton Community Hospital Princeton, West Virginia | |
| Prisma Health Greenville Memorial Hospital Greenville, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Providence Veterans Administration Hospital Providence, Rhode Island | |
| Puerto Rico Hematology Oncology Group Bayamón, | |
| Queen's Cancer Center - Kuakini Honolulu, Hawaii | |
| Queen's Cancer Center - Pearlridge ‘Aiea, Hawaii | |
| Queen's Medical Center Honolulu, Hawaii | |
| Radiation Oncology Associates Reno, Nevada | Site Public Contact - (research@sncrf.org) |
| Radiation Oncology Centers of Nevada Central Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Radiation Oncology Centers of Nevada Southeast Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Ralph H Johnson VA Medical Center Charleston, South Carolina | Site Public Contact - (ashley.salvo@va.gov) |
| Regions Hospital Saint Paul, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Reid Health Richmond, Indiana | |
| Renown Regional Medical Center Reno, Nevada | Site Public Contact - (research@sncrf.org) |
| Rice Memorial Hospital Willmar, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Ridgeview Medical Center Waconia, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Riverwood Healthcare Center Aitkin, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Robert J Dole VA Medical Center Wichita, Kansas | |
| Rocky Mountain Cancer Centers - Centennial Centennial, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers - Swedish Englewood, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Aurora Aurora, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Boulder Boulder, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Lakewood Lakewood, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Littleton Littleton, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Longmont Longmont, Colorado | Site Public Contact - (ResearchTracking@Centura.Org) |
| Rocky Mountain Cancer Centers-Midtown Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Penrose Colorado Springs, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Rocky Mountain Cancer Centers-Rose Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Thornton Thornton, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Regional VA Medical Center Aurora, Colorado | |
| Rush MD Anderson Cancer Center Chicago, Illinois | |
| Rush-Copley Healthcare Center Yorkville, Illinois | |
| Rush-Copley Medical Center Aurora, Illinois | |
| SMC Center for Hematology Oncology Union Union, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| SSM Health Good Samaritan Mount Vernon, Illinois | Site Public Contact - (gayla.hall@ssmhealth.com) |
| Saint Alphonsus Cancer Care Center-Baker City Baker City, Oregon | |
| Saint Alphonsus Cancer Care Center-Boise Boise, Idaho | |
| Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho | |
| Saint Alphonsus Cancer Care Center-Nampa Nampa, Idaho | |
| Saint Alphonsus Cancer Care Center-Ontario Ontario, Oregon | |
| Saint Anthony North Hospital Westminster, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Catherine Hospital Indianapolis, Indiana | Site Public Contact - (Roster@nrgoncology.org) |
| Saint Clare Hospital Lakewood, Washington | |
| Saint Elizabeth Boardman Hospital Boardman, Ohio | |
| Saint Elizabeth Healthcare Edgewood Edgewood, Kentucky | Site Public Contact - (Kristi.Curtsinger@stelizabeth.com) |
| Saint Elizabeth Healthcare Fort Thomas Fort Thomas, Kentucky | |
| Saint Elizabeth Hospital Enumclaw, Washington | |
| Saint Elizabeth Regional Medical Center Lincoln, Nebraska | |
| Saint Elizabeth Youngstown Hospital Youngstown, Ohio | |
| Saint Francis Cancer Center Greenville, South Carolina | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Francis Hospital Greenville, South Carolina | |
| Saint Francis Regional Medical Center Shakopee, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Saint John's Hospital - Healtheast Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Saint Joseph Hospital Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Hospital East Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph London London, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Medical Center Hematology and Oncology - Silverdale Silverdale, Washington | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Mount Sterling Mount Sterling, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Radiation Oncology Resource Center Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Regional Cancer Center Bryan, Texas | |
| Saint Joseph Warren Hospital Warren, Ohio | |
| Saint Joseph's Medical Center Stockton, California | |
| Saint Luke's Cancer Center - Allentown Allentown, Pennsylvania | |
| Saint Luke's Hospital - Monroe Campus Stroudsburg, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| Saint Luke's Hospital - Upper Bucks Campus Quakertown, Pennsylvania | |
| Saint Luke's Hospital-Anderson Campus Easton, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| Saint Luke's University Hospital-Bethlehem Campus Bethlehem, Pennsylvania | |
| Saint Mary Corwin Medical Center Pueblo, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Mary Medical Center Hobart, Indiana | Site Public Contact - (CancerResearch@COMHS.org) |
| Saint Mary's Hospital Centralia, Illinois | |
| Saint Mary's Regional Medical Center Reno, Nevada | Site Public Contact - (research@sncrf.org) |
| Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin | Site Public Contact - (WI_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Saints Mary and Elizabeth Hospital Louisville, Kentucky | |
| San Juan City Hospital San Juan, | |
| San Juan Community Oncology Group San Juan, | |
| San Juan Veterans Affairs Medical Center San Juan, | Site Public Contact - (sajresearchcontactus@va.gov) |
| Sanford Bismarck Medical Center Bismarck, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford Broadway Medical Center Fargo, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota | Site Public Contact - (OncologyClinicTrialsSF@sanfordhealth.org) |
| Sanford Cancer Center Worthington Worthington, Minnesota | |
| Sanford Joe Lueken Cancer Center Bemidji, Minnesota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford Medical Center Fargo Fargo, North Dakota | |
| Sanford Roger Maris Cancer Center Fargo, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford South University Medical Center Fargo, North Dakota | |
| Sanford Thief River Falls Medical Center Thief River Falls, Minnesota | |
| Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota | Site Public Contact - (OncologyClinicalTrialsSF@SanfordHealth.org) |
| Southeastern Medical Oncology Center-Clinton Clinton, North Carolina | Site Public Contact - (jfields@cancersmoc.com) |
| Southeastern Medical Oncology Center-Goldsboro Goldsboro, North Carolina | Site Public Contact - (jfields@cancersmoc.com) |
| Southeastern Medical Oncology Center-Jacksonville Jacksonville, North Carolina | Site Public Contact - (jfields@cancersmoc.com) |
| Southpointe-Sanford Medical Center Fargo Fargo, North Dakota | |
| Sovah Health Martinsville Martinsville, Virginia | |
| Spartanburg Medical Center Spartanburg, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Spartanburg Medical Center - Mary Black Campus Spartanburg, South Carolina | |
| Stanford Cancer Institute Palo Alto Palo Alto, California | Site Public Contact - (ccto-office@stanford.edu) |
| Straub Clinic and Hospital Honolulu, Hawaii | |
| Summerlin Hospital Medical Center Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Sunrise Hospital and Medical Center Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Tamarack Health Hayward Medical Center Hayward, Wisconsin | |
| The Carle Foundation Hospital Urbana, Illinois | |
| The Community Hospital Munster, Indiana | |
| The Melanoma and Skin Cancer Institute Englewood, Colorado | Site Public Contact - (ryan.weight@theskincancerinstitute.com) |
| The Women's Imaging Center Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| TriHealth Cancer Institute-Anderson Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| TriHealth Cancer Institute-Westside Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Trinity Health Grand Rapids Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Trinity Health Muskegon Hospital Muskegon, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| UCHealth University of Colorado Hospital Aurora, Colorado | |
| UCLA / Jonsson Comprehensive Cancer Center Los Angeles, California | |
| UHHS-Chagrin Highlands Medical Center Beachwood, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| UHHS-Westlake Medical Center Westlake, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines, Iowa | |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa | |
| UPMC-Presbyterian Hospital Pittsburgh, Pennsylvania | |
| UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas | |
| United Hospital Saint Paul, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| United Hospital Center Bridgeport, West Virginia | Site Public Contact - (cancertrialsinfo@hsc.wvu.edu) |
| Unity Hospital Fridley, Minnesota | |
| University Cancer Center Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| University Medical Center of Southern Nevada Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| University of Arizona Cancer Center - Prevention Research Clinic Tucson, Arizona | Site Public Contact - (pcarino@arizona.edu) |
| University of Cincinnati Cancer Center-UC Medical Center Cincinnati, Ohio | |
| University of Cincinnati Cancer Center-West Chester West Chester, Ohio | |
| University of Hawaii Cancer Center Honolulu, Hawaii | |
| University of Kansas Cancer Center Kansas City, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Clinical Research Center Fairway, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Hospital-Indian Creek Campus Overland Park, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida | |
| University of Michigan Health - West Wyoming, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| University of Michigan Rogel Cancer Center Ann Arbor, Michigan | |
| University of New Mexico Cancer Center Albuquerque, New Mexico | Site Public Contact - (HSC-ClinicalTrialInfo@salud.unm.edu) |
| UofL Health Medical Center Northeast Louisville, Kentucky | |
| Upper Valley Medical Center Troy, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Urology Specialists of Nevada - Central Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Urology Specialists of Nevada - Green Valley Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Urology Specialists of Nevada - Northwest Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Urology Specialists of Nevada - Southwest Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| VCU Massey Cancer Center at Stony Point Richmond, Virginia | Site Public Contact - (ctoclinops@vcu.edu) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| Valley Medical Center Renton, Washington | Site Public Contact - (research@valleymed.org) |
| Veterans Administration Medical Center - Oklahoma City Oklahoma City, Oklahoma | Site Public Contact - (Roster@nrgoncology.org) |
| Veterans Affairs Connecticut Healthcare System-West Haven Campus West Haven, Connecticut | |
| WVUH-Berkely Medical Center Martinsburg, West Virginia | Site Public Contact - (cancertrialsinfo@hsc.wvu.edu) |
| Walter Knox Memorial Hospital Emmett, Idaho | |
| Wayne Hospital Greenville, Ohio | |
| Welch Cancer Center Sheridan, Wyoming | |
| West Michigan Cancer Center Kalamazoo, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| West Virginia University Healthcare Morgantown, West Virginia | Site Public Contact - (cancertrialsinfo@hsc.wvu.edu) |
| Wheeling Hospital/Schiffler Cancer Center Wheeling, West Virginia | |
| Wilcox Memorial Hospital and Kauai Medical Clinic Lihue, Hawaii | |
| William S Middleton VA Medical Center Madison, Wisconsin | |
| Women's Cancer Center of Nevada Las Vegas, Nevada | |
| Women's Diagnostic Center - Munster Munster, Indiana | Site Public Contact - (mnicholson@comhs.org) |
| Woodland Memorial Hospital Woodland, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Yale University New Haven, Connecticut | Site Public Contact - (canceranswers@yale.edu) |
| Yale-New Haven Hospital North Haven Medical Center North Haven, Connecticut | Site Public Contact - (canceranswers@yale.edu) |
| Yale-New Haven Hospital Saint Raphael Campus New Haven, Connecticut | Site Public Contact - (canceranswers@yale.edu) |
| Zablocki Veterans Administration Medical Center Milwaukee, Wisconsin |
Safety and Effectiveness of Cochlear Implantation in an Expanded Adult Population (ACE)
Lavin Entwisle - lentwisle@cochlear.com
NCT06293482
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Inclusion Criteria:
* Individuals 18 or older at the time of consent
* Meets the following audiometric criteria for the ear to be implanted: clinically established sensorineural hearing loss (SNHL) defined by a four frequency pure tone average (PTA) at 500, 1000, 2000, \& 4000 Hz of: ≥60 dB HL and compromised functional hearing in the aided condition defined as \<50% correct on a word recognition test
* Meets the following audiometric criteria for the non-implanted contralateral ear: clinically established SNHL defined by a four frequency PTA at 500, 1000, 2000, \& 4000 Hz of \>30 dB HL
* Candidate is a fluent speaker in the language used to assess speech perception performance as determined by the investigator.
* Willing and able to provide written informed consent.
Exclusion Criteria:
* Meets current indications on audiometric thresholds for traditional adult CI candidates (i.e., bilateral moderate to profound hearing loss in the low frequencies and profound \[≥ 90 dB HL\] hearing loss in the mid to high speech frequencies)
* Absence of cochlea development or a cochlear nerve
* Presence of active middle ear infection in the ear to be implanted
* Tympanic membrane perforation in the presence of active middle ear disease in the ear to be implanted
* Medical or psychological conditions that contraindicate general anaesthesia, surgery, or participation in the clinical investigation.
* Existing contralateral cochlear implant or medical plan to implant a contralateral cochlear implant during the clinical investigation.
* Pregnant or breastfeeding women. Women who plan to become pregnant during the course of the clinical investigation.
* Unrealistic expectations on the part of the participant, regarding the possible benefits, risks, and limitations that are inherent to the surgical procedure(s) and prosthetic devices as determined by the investigator.
* Additional disabilities that may affect the participant's participation of safety during the clinical investigation.
* Unable or unwilling to comply with all of the requirements of the clinical investigation as determined by the investigator.
* Investigator site personnel directly affiliated with this study and/or their immediate families; immediate family is defined as a spouse, parent, child, or sibling.
* Employees of Cochlear.
* Current participation, or participation in another interventional clinical study/trial in the past 30 days, involving an investigational drug or device (unless the other investigation was/is a Cochlear sponsored investigation and determined by the investigator or Sponsor to not impact this investigation. DEVICE: Cochlear™ Nucleus® System
Hearing Loss, Sensorineural, Hearing Loss, Bilateral
Cochlear implant, Sensorineural hearing loss, Safety, Efficacy
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Study Locations
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| Location | Contacts |
|---|---|
| Barrow Neurological Institute Phoenix, Arizona | Shawn Stevens - (shawn.stevens@commonspirit.org) |
| Centre for Neurosciences Tucson, Arizona | Gwendolyn Grabiec - (GGrabiec@neurotucson.com) |
| Cleveland Clinic Cleveland, Ohio | Sarah Sydlowski - (sydlows@ccf.org) |
| Indiana University Indianapolis, Indiana | Rick Nelson, MD - (ricnelso@iupui.edu) |
| Midwest Ear Institute Kansas City, Missouri | Sarah Zlomke - (sking@saint-lukes.org) |
| New York University New York, New York | William Shapiro - (william.shapiro@nyulangone.org) |
| Pacific Neuroscience Institute Santa Monica, California | Courtney Voelker, MD - (Courtney.Voelker@providence.org) |
| University of Miami Miami, Florida | Meredith Holcomb - (meredith.holcomb@med.miami.edu) |
| University of Pennsylvania Hospitals Philadelphia, Pennsylvania | Tiffany Hwa - (tiffany.hwa@pennmedicine.upenn.edu) |
| Virginia Commonwealth University Henrico, Virginia | |
| Virginia Mason Seattle, Washington |
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
Clinical Trials Administrator - clinicaltrials@regeneron.com
NCT03564340
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Key
• Ovarian Cancer Cohorts Only: Patients with histologically or cytologically confirmed diagnosis of advanced, epithelial ovarian cancer (except carcinosarcoma), primary peritoneal, or fallopian tube cancer who have all of the following:
• serum CA-125 level ≥2 x upper limit of normal (ULN) (in screening, not required for low-grade serous carcinoma)
• has received at least 1 line of platinum-containing therapy or must be platinum-intolerant (applicable for dose escalation and non-randomized dose expansion cohorts)
• documented relapse or progression on or after the most recent line of therapy
• no standard therapy options likely to convey clinical benefit
• Adequate organ and bone marrow function as defined in the protocol
• Life expectancy of at least 3 months
• Randomized phase 2 expansion cohort (Ovarian Cancer only): Platinum-resistant ovarian cancer patients who have had 2 to 4 lines of platinum-based therapy as defined in the protocol.
• Endometrial Cancer Cohorts Only: histologically confirmed endometrial cancer that has progressed or recurrent after prior anti-Programmed Cell Death Ligand 1 (PD-1) therapy and platinum-based chemotherapy:
• MUC16 positivity of tumor cells ≥25% by immunohistochemistry (IHC), as defined in the protocol
• 1-4 prior lines of systemic therapy, as described in the protocol Key
• Prior treatment with anti-Programmed Cell Death (PD-1)/PD-L1 therapy, as described in the protocol
• Ovarian Cancer Expansion cohorts only: More than 4 prior lines of cytotoxic chemotherapy (does not apply to low-grade serous ovarian cancer cohort)
• Prior treatment with a MUC16 - targeted therapy
• Untreated or active primary brain tumor, central nervous system (CNS) metastases, or spinal cord compression, as described in the protocol
• History and/or current cardiovascular disease, as defined in the protocol
• Severe and/or uncontrolled hypertension at screening. Patients taking anti-hypertensive medication must be on a stable anti-hypertensive regimen Note: Other protocol-defined Inclusion/Exclusion Criteria apply
Inclusion Criteria:
• Ovarian Cancer Cohorts Only: Patients with histologically or cytologically confirmed diagnosis of advanced, epithelial ovarian cancer (except carcinosarcoma), primary peritoneal, or fallopian tube cancer who have all of the following:
• serum CA-125 level ≥2 x upper limit of normal (ULN) (in screening, not required for low-grade serous carcinoma)
• has received at least 1 line of platinum-containing therapy or must be platinum-intolerant (applicable for dose escalation and non-randomized dose expansion cohorts)
• documented relapse or progression on or after the most recent line of therapy
• no standard therapy options likely to convey clinical benefit
• Adequate organ and bone marrow function as defined in the protocol
• Life expectancy of at least 3 months
• Randomized phase 2 expansion cohort (Ovarian Cancer only): Platinum-resistant ovarian cancer patients who have had 2 to 4 lines of platinum-based therapy as defined in the protocol.
• Endometrial Cancer Cohorts Only: histologically confirmed endometrial cancer that has progressed or recurrent after prior anti-Programmed Cell Death Ligand 1 (PD-1) therapy and platinum-based chemotherapy:
• MUC16 positivity of tumor cells ≥25% by immunohistochemistry (IHC), as defined in the protocol
• 1-4 prior lines of systemic therapy, as described in the protocol Key
Exclusion Criteria:
• Prior treatment with anti-Programmed Cell Death (PD-1)/PD-L1 therapy, as described in the protocol
• Ovarian Cancer Expansion cohorts only: More than 4 prior lines of cytotoxic chemotherapy (does not apply to low-grade serous ovarian cancer cohort)
• Prior treatment with a MUC16 - targeted therapy
• Untreated or active primary brain tumor, central nervous system (CNS) metastases, or spinal cord compression, as described in the protocol
• History and/or current cardiovascular disease, as defined in the protocol
• Severe and/or uncontrolled hypertension at screening. Patients taking anti-hypertensive medication must be on a stable anti-hypertensive regimen Note: Other protocol-defined Inclusion/Exclusion Criteria apply
DRUG: Ubamatamab, DRUG: Cemiplimab, DRUG: Sarilumab, DRUG: Tocilizumab
Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Primary Peritoneal Cancer, Recurrent Endometrial Cancer, Endometrial Cancer, Low-grade Serous Ovarian Cancer
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Show 52 locations
Study Locations
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| Location | Contacts |
|---|---|
| Asan Medical Center, Univ. of Ulsan Seoul, | |
| Centre Antoine Lacassagne Nice, | |
| Centre Francois Baclesse (CFB) Caen, Normandy | |
| Centre Georges Francois Leclerc Dijon, | |
| Clinica Universidad Navarra (CUN) Madrid Madrid, | |
| Clinica Universidad de Navarra Pamplona, Navarre | |
| Columbia University Medical Center New York, New York | |
| Dana Farber / Harvard Cancer Center Boston, Massachusetts | |
| Erasmus MC Rotterdam, South Holland | |
| Fondazione Policlinico Universitario Agostino Gemelli Irccs Roma, | |
| Fundacion Jimenez Diaz Madrid, | |
| Grand Hopital de Charleroi Charleroi, Hainaut | |
| Guys Hospital London, | |
| Hopital Lyon Sud Pierre-Bénite, Auvergne-Rhône | |
| Hospital Clinico Universitatio Santiago de Compostela Santiago de Compostela, | |
| Hospital Universitari Vall d'Hebron Barcelona, | |
| Hospital Universitario San Carlos Madrid, | |
| Humanitas S. Pio X Milan, | |
| Imperial College Healthcare NHS Trust London, England | |
| Institut Bergonie Bordeaux, | |
| Institut Catala d'Oncologia Barcelona, | |
| Institut Catala dOncologia Badalona Badalona, | |
| Institut Gustave Roussy Villejuif, | |
| Instituto Nazionale Tumori- Fondazione Pascale Naples, | |
| Istituto Europeo Di Oncologia Milan, | |
| Korea University Guro Hospital Seoul, | |
| Massachusetts General Hospital Boston, Massachusetts | |
| Mayo Clinic - Rochester Rochester, Minnesota | |
| Memorial Sloan Kettering Cancer Center New York, New York | |
| Peter MacCallum Cancer Center Melbourne, | |
| Prince of Wales Hospital Shatin, New Territories | |
| Radboudumc Nijmegen, | |
| Rambam Health Care Campus Haifa, | |
| Roswell Park Cancer Institute Buffalo, New York | |
| Royal Marsden Hospital - Sutton Sutton, Surrey | |
| Samsung Medical Center Seoul, | |
| Sarah Cannon Research Institute Nashville, Tennessee | |
| Seoul National University Hospital Seoul, Seoul Teugbyeolsi | |
| Sharet Institute of Oncology Jerusalem, | |
| Sheba Medical Center Ramat Gan, | |
| Stephenson Cancer Center Oklahoma City, Oklahoma | |
| The Christie NHS Foundation Trust Manchester, | |
| The Ohio State University Wexner Medical Center James Comprehensive Cancer Center Hilliard, Ohio | |
| The Royal Marsden NHS Foundation Trust London, | |
| UZLeuven Leuven, Vlaams-Brabant | |
| Universitair Ziekenhuis Antwerpen Edegem, Antwerpen | |
| University College London Hospitals London, | |
| University Medical Center Groningen Groningen, | |
| University of Alabama_6th Ave Birmingham, Alabama | |
| University of Oxford Oxford, Oxfordshire | |
| Virginia Commonwealth University Henrico, Virginia | |
| Yonsei University Health System Seoul, |
Psychobiological Responses Following Exercise and Brain Stimulation
Edmund Acevedo - eoacevedo@vcu.edu
NCT06874595
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Inclusion Criteria:
* Healthy adults
* aged 18 to 50
* consent and complete a Physical Activity Readiness Questionnaire (PAR-Q)
* be free from any neurological or psychiatric disorder
* not be taking any medication that could affect the central nervous system
* not have any contraindication for HD-tDCS (i.e. not having metal implanted in the head, pacemaker, medical bumps, seizures, lesions on the scalp or head ) or for bioelectrical impedance (i.e., electronic medical implant, such as a pacemaker or implantable cardioverter defibrillator, and limb amputation)
* not be regular users of tobacco products (cigarettes, cigars, chewing tobacco)
* not consume an average of more than ten alcoholic beverages per week
Exclusion Criteria:
* Individuals who do not meet the PAR-Q screening criteria for participation in moderate physical activity will be excluded from participating in this study
* women who are pregnant will be exclude from this study OTHER: Cycling exercise at 65% of HRR for 20 minutes followed by HD-tDCS (exercise + HD-tDCS), OTHER: Cycling exercise at 65% of HRR exercise followed by sham HD-tDCS (exercise + sham tDCS), OTHER: No exercise followed by HD-tDCS (no exercise + HD-tDCS)., OTHER: State Anxiety Inventory, OTHER: Visual Analog Scale for Anxiety
Psychological
Exercise and Brain Stimulation
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| Location | Contacts |
|---|---|
| Virginia Commonwealth University Henrico, Virginia | Edmund Acevedo, PhD - (eoacevedo@vcu.edu) |
Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Children With ADHD
Joseph T Hull, PhD - jhull@supernus.com
NCT04781140
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Inclusion Criteria:
• Is male or female 4 years 0 months of age to less than or equal to 5 years 9 months of age at Visit 1 (Screening) and considered medically healthy.
• Subject's parent(s) or legal guardian(s)/representative(s) is (are) willing and able to provide written informed consent before completing any study related procedures.
• Has a primary diagnosis of ADHD according to DSM-IV-TR criteria and confirmed with the Kiddie Schedule for Affective Disorders and Schizophrenia - Present and Lifetime Version (K-SADS-PL).
• Has an ADHD-RS-IV-P Total Score of ≥ 28 (males) or ≥ 24 (females) at Visit 1 (Screening) and at Visit 2 (Baseline).
• Has a CGI-S score of ≥ 4 (moderate or worse) at Visit 1 (Screening) and at Visit 2 (Baseline).
• Has undergone an adequate course of non-pharmacologic treatment or is having symptoms severe enough to warrant pharmacologic treatment without prior non-pharmacologic treatment.
• Is participating in a structured group activity (e.g., preschool, kindergarten, sports, Sunday school, summer camp or childcare program) at least 2 days a week during study so as to assess symptoms and impairment in a setting outside the home.
• Has not initiated any behavioral intervention/therapy within 30 days of Visit 1 (Screening) and does not plan to initiate any new or discontinue any ongoing behavioral intervention/therapy during the study (e.g., subject is eligible if behavioral intervention/therapy is initiated 30 or more days prior to Visit 1 \[Screening\] and continues with a similar duration/frequency throughout their study).
• Subjects who are on ADHD medication at Visit 1 (Screening), but whose ADHD symptoms are not well controlled on current ADHD medication (e.g., meets Inclusion Criterion #4), meet all other inclusion/exclusion criteria, and discontinues ADHD medication at least 7 days prior to the day of Visit 2 (Baseline) are eligible to participate.
• Has no current condition in the opinion of the Investigator that could confound efficacy assessments, safety assessments or increase participant risk.
• Has lived with the same parent(s) or legal guardian(s) or has lived under a shared living arrangement (e.g., joint legal custody) for greater than or equal to 6 months prior to Visit 1 (Screening).
• Has a body weight ≥5th percentile for age and sex at Visit 1 (Screening) and Visit 2 (Baseline).
Exclusion Criteria:
• Has a diagnosis at Screening (per K-SADS-PL) of another psychiatric disorder that is considered to be the primary diagnosis rather than ADHD or has a comorbid psychiatric disorder secondary to ADHD that, in the opinion of the investigator (after consulting medical monitor), will likely interfere with study treatment adherence and/or impact study results.
• Has a current diagnosis of a major neurological disorder. The eligibility of those who have seizures, a history of seizure-like events (e.g., syncope, myoclonus, severe muscle spasms), a family history of seizure disorder (immediate family, i.e., sibling, parent), and/or febrile seizures will be assessed on a case-by-case basis after consulting the medical monitor.
• History of Bipolar Disorder diagnosed in a first degree relative.
• Has global development delay or intellectual disability by medical history.
• Has a current diagnosis of a significant (per Investigator's evaluation and/or judgement) systemic disease.
• Has body mass index \> 95th percentile for the subject's age and sex at Visit 1 (Screening) or Visit 2 (Baseline).
• Has a mean resting systolic and diastolic blood pressure\* that are both \>95th percentile for age sex, and height and has a mean resting pulse rate\* that is \>95th percentile for age and sex (males: \>117 bpm; females: \>122 bpm) at Visit 1 (Screening) or Visit 2 (Baseline). \* Note: The mean of three measurements while seated.
• Has a clinically significant electrocardiogram finding(s) at Visit 1 (Screening).
• Is currently taking SPN-812 for ADHD, has previously taken SPN-812 for ADHD, but discontinued due to a lack of efficacy or adverse reactions, or has history of allergic reaction, hypersensitivity or intolerance to viloxazine.
• Has an allergy to or cannot swallow pudding and applesauce and cannot swallow intact capsule whole.
• Has any food allergy, intolerance, restriction or special diet that, in the opinion of the Investigator, could contraindicate the subject's participation in the study.
• Has received any investigational drug within the longer of 30 days or 5 half-lives prior to Visit 2 (e.g., first dose of study medication).
• Has a positive urine drug test at Visit 1 (Screening). A positive test for amphetamines is allowed for subjects receiving a stimulant ADHD medication at Screening. The subject will be required to discontinue the stimulant for the duration of the study, beginning at least 7 days prior to Visit 2 (Baseline).
• Is using of prohibited concomitant medications including known CYP1A2 substrates (e.g., theophylline, melatonin) during the Screening Period or (anticipated) for the duration of the study.
• Any reason that, in the opinion of the Investigator, would prevent the subject from participating in the study.
• Has suicidal ideation ("Yes" indicated on C-SSRS question 4 or 5) or suicidal behavior ("Yes" indicated on C-SSRS for any suicidal behavior) within 6 months prior to or the day of Visit 1 (Screening) or has attempted suicide ("Yes" indicated on C-SSRS for lifetime).
DRUG: 100mg SPN-812, DRUG: Placebo
Attention-Deficit/Hyperactivity Disorder
ADHD
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| Location | Contacts |
|---|---|
| AIM Trials, LLC Plano, Texas | - (info@aimtrials.com) |
| APG Research LLC Orlando, Florida | - (kkenworthyapg@gmail.com) |
| Advanced Discovery Research LLC Atlanta, Georgia | - (contact@advdiscovery.com) |
| Advanced Research Center (ARC), Inc. Anaheim, California | - (contact@arctrials.com) |
| Alliance Research Long Beach, California | - (Research@asclepes.com) |
| Avantis Clinical Research LLC Miami, Florida | - (info@avantisclinicalresearch.com) |
| Boston Children's Hospital Boston, Massachusetts | - (benamin.mills@childrens.harvard.edu) |
| CenExcel iResearch, LLC Decatur, Georgia | |
| CenExel iResearch, LLC. Savannah, Georgia | |
| Cincinnati Children's Hospital and Medical Center Cincinnati, Ohio | - (ADHDResearch@cchmc.org) |
| CincyScience West Chester, Ohio | - (research@cincyscience.com) |
| Clinical Integrative Research Center of Atlanta Atlanta, Georgia | |
| Clinical NeuroScience Solutions, Inc. Memphis, Tennessee | |
| Clinical NeuroScience Solutions, Inc. Memphis, Tennessee | - (orlinfo@cnshealthcare.com) |
| Clinical NeuroScience Solutions, Inc. Memphis, Tennessee | |
| Clinical Research Partners, LLC Petersburg, Virginia | - (Recruitment@ClinicalResearchRVA.com) |
| Clinical Research of Southern Nevada, LLC. Las Vegas, Nevada | - (kluna.cpbm@gmail.com) |
| Coastal Carolina Research Center North Charleston, South Carolina | - (CCRC@CoastalCarolinaResearch.com) |
| Coastal Pediatric Research Summerville, South Carolina | - (info.research@cpakids.com) |
| Cyn3rgy Research Gresham, Oregon | - (support@cyn3rgy.com) |
| D&H Tamarac Research Center Tamarac, Florida | - (info@dhnrc.com) |
| DelRicht Research Prairieville, Louisiana | - (info@delricht.com) |
| DelRicht Research (Touro Medical Center) New Orleans, Louisiana | - (info@delricht.com) |
| Duke University Durham, North Carolina | |
| Family Psych of The Woodlands The Woodlands, Texas | - (info@woodlandspsych.com) |
| Hope Research Network, LLC. Miami, Florida | - (info@hoperesearchnetwork.com) |
| Houston Clinical Trials, LLC. Bellaire, Texas | |
| IMMUNOe Research Centers Centennial, Colorado | - (verosinfo@veroshealth.com) |
| Icahn School of Medicine at Mount Sinai New York, New York | - (adhd.research@mssm.edu) |
| Javara Dallas, Texas | |
| Jersey Shore University Medical Center Neptune City, New Jersey | - (andrew.layman@hmhn.org) |
| Kennedy Krieger Institute Baltimore, Maryland | |
| Kentucky Pediatric/Adult Research Bardstown, Kentucky | - (kpar@kpar.us) |
| Luna Research Center Coral Gables, Florida | |
| Med Clinical Research Irvington, New Jersey | - (info@medclinicalresearch.com) |
| Medical Research Group of Central Florida Orange City, Florida | |
| Neurobehavioral Medicine Group Bloomfield Hills, Michigan | - (info@neurobmg.com) |
| Pediatric Neurology and Epilepsy Specialists Winter Park, Florida | - (ARiveraDelValle@pediatricneurologyandepilepsy.com) - (DHubert@pediatricneurologyandepilepsy.com) |
| Penn State Health Medical Group - Psychiatry and Behavioral Health Hershey, Pennsylvania | - (rmyers12@pennstatehealth.psu.edu) |
| Precise Research Centers Flowood, Mississippi | |
| Preferred Research Partners, Inc. Little Rock, Arkansas | - (info@preferredresearchpartners.com) |
| Qualmedica Research, LLC. Owensboro, Kentucky | |
| Qualmedica Research, LLC. Owensboro, Kentucky | |
| Sarkis Clinical Trials Gainesville, Florida | |
| Sun Valley Research Center Imperial, California | - (svrcinfo@sunvalleyb.com) |
| The Center for Clinical Trials, Inc. Saraland, Alabama | - (info@thecenterforclinicaltrials.com) |
| Virginia Commonwealth University, Virginia Treatment Center for Children Richmond, Virginia |
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
Novartis Pharmaceuticals - novartis.email@novartis.com
NCT05268289
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Inclusion Criteria:
Unequivocally positive ANA test result and/or a positive anti dsDNA at screening Active biopsy-proven lupus nephritis within 3 months of screening demonstrating Class III or IV lupus nephritis with or without co-existing features of Class V lupus nephritis.
Documentation of active renal disease at the time of screening necessitating the commencement of therapy with corticosteroids in combination with MMF/MPS.
eGFR ≥ 30 ml/min/1.73 m2 Vaccination against Neisseria meningitidis and Streptococcus pneumoniae infections Vaccination against Haemophilus influenzae infection Supportive care including stable dose regimen of anti-malarials (e.g. hydroxychloroquine) unless contraindicated, ACEi or ARB at either locally approved maximal daily dose or the maximally tolerated dose (per investigators' judgement) at screening, as per the local clinical practice. Doses should remain stable throughout the study.
First presentation or flare of lupus nephritis.
Exclusion Criteria:
Induction treatment with cyclophosphamide within 3 months of planned treatment for this study; treatment with calcineurin inhibitors within the previous 3 months prior to randomization.
Presence of rapidly progressive glomerulonephritis (RPGN) as defined by 50% decline in eGFR within 3 months prior to screening.
Renal biopsy presenting with interstitial fibrosis/tubular atrophy (IF/TA) or glomerulosclerosis of more than 50%, or which in the opinion of the investigator is such that it precludes likely response to immunosuppressive therapy.
Participants being treated with systemic corticosteroids (\>5 mg/day prednisone or equivalent) for indications other than SLE or LN e.g. acute asthma, inflammatory bowel disease.
Participants being treated with systemic corticosteroids for SLE or LN will be excluded if they have taken more than an average of 15 mg/day prednisone (or equivalent) in the previous 4 weeks and more than an average of 30 mg/day in the previous 1 week Receipt of more than a total dose of 1000 mg equivalent i.v. pulse methylprednisolone (cumulative dose) within 2 weeks prior to enrollment (and at enrollment)
Other protocol-defined inclusion/exclusion criteria may apply DRUG: Iptacopan (part 1), DRUG: Iptacopan (part 2), DRUG: Placebo + standard of care, DRUG: Iptacopan + placebo
Lupus Nephritis
LNP023, Iptacopan, Lupus Nephritis, proteinuria, Urine Protein-to-Creatinine Ratio, complete renal response, estimated glomerular filtration rate, renal flares, Systemic Lupus Erythematosus
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Show 103 locations
Study Locations
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| Location | Contacts |
|---|---|
| AKDHC Medical Research ServicesLLC Phoenix, Arizona | |
| Allegheny Health Network Pittsburgh, Pennsylvania | |
| Brigham and Womens Hosp Harvard Med School Boston, Massachusetts | Valentina Castro - (vcastro3@bwh.harvard.edu) |
| Cleveland Clinic Foundation Cleveland, Ohio | Vivian Jeffreys - (jefferv@ccf.org) |
| Dallas Nephrology Associates Dallas, Texas | |
| FDI Clinical Research San Juan, | Digmarie Rivera Franceschini - (drivera@fdipr.com) |
| Florida Kidney Physicians Riverview, Florida | Myra Rodriguez - (mrodriguez@panoramichealth.com) |
| Florida Kidney Physicians Riverview, Florida | Yvette Martinez - (ymartinez@panoramichealth.com) |
| Johns Hopkins Hospital Baltimore, Maryland | |
| Kaiser Permanente Fontana Fontana, California | |
| Loma Linda University San Bernardino, California | |
| Mayo Clinic Jacksonville Jacksonville, Florida | Tia Wilkes - (Wilkes.Quantia@mayo.edu) |
| Mayo Clinic Rochester Rochester, Minnesota | |
| Nep Assoc of Northern Illinois Hinsdale, Illinois | |
| Nephrology Associates Of Central FL Orlando, Florida | |
| Novartis Investigative Site Leicester, | |
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| Novartis Investigative Site Leicester, | |
| Ochsner Health System New Orleans, Louisiana | Gavin Skipper - (gavin.skipper@ochsner.org) |
| Olive View UCLA Medical Center Sylmar, California | |
| Prolato Clinical Research Center Houston, Texas | Dilshad Begum - (dbegum@prolato.org) |
| Ronald Reagan UCLA Medical Center Los Angeles, California | Rana Nikbakht Malvajerdi - (RNikbakht@mednet.ucla.edu) |
| Royal Research Corp Hollywood, Florida | Yaili Perez - (yailip@royalresearchcorp.com) |
| Stony Brook Internists PC East Setauket, New York | Asad Syed - (asad.syed@stonybrookmedicine.edu) |
| Temple University Philadelphia, Pennsylvania | Julia Aruta - (julia.aruta@temple.edu) |
| Univ Calif Irvine Irvine, California | |
| University of Colorado Denver Aurora, Colorado | Elizabeth Wagner - (Elizabeth.C.Wagner@cuanschutz.edu) |
| University of Nebraska Medical Center Omaha, Nebraska | |
| Virginia Commonwealth University Henrico, Virginia | Keila Najera - (Keila.Najera@vcuhealth.org) |
| Wichita Community Clcl Onco Program Wichita, Kansas | Barb Johnson - (Bjohnson@wngpa.com) |
The Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART) (AID-HEART)
Benjamin VanTassell - bvantassell@vcu.edu
NCT06062966
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Inclusion Criteria:
* Primary diagnosis for the clinic visit is stage D heart failure being on chronic stable dose of inotrope therapy (dobutamine or milrinone for the previous 28 days)
* Prior documentation of impaired left ventricular systolic function (ejection fraction \<50%) at most recent assessment by any imaging modality (within 12 months)
* Stable dose of inotrope treatment without a recent hospitalization within the previous month
* Age ≥21 years and willing/able to provide written informed consent
* The patient is willing and able to comply with the protocol (i.e. self administration of the treatment, and exercise protocol).
* Screening plasma C-reactive protein levels \>2 mg/L
Exclusion Criteria:
* Concomitant clinically significant comorbidities including (but not limited to) acute coronary syndromes, uncontrolled hypertension or orthostatic hypotension, tachy- or brady-arrhythmias, acute or chronic pulmonary disease or neuromuscular disorders affecting respiration that would interfere with the execution, interpretation, or completion of the study
* Recent (previous 3 months) or planned resynchronization therapy (CRT), or valve surgeries
* Previous or planned implantation of left ventricular assist devices or heart transplant within the next 3 months
* Recent (\<14 days) use of immunosuppressive or anti-inflammatory drugs (including oral corticosteroids at a dose of prednisone equivalent of 0.5 mg/kg/day but not including inhaled or low dose oral corticosteroids or non-steroidal anti-inflammatory drugs)
* Chronic inflammatory disorder (including but not limited to rheumatoid arthritis, systemic lupus erythematosus)
* Active infection (of any type), including chronic/recurrent infectious disease (including HBV, HCV, and HIV/AIDS) - but excluding HCV+ with undetectable plasma RNA
* Prior (within the past 5 years) or current malignancy on targeted treatment - excluding carcinoma in situ \[any location\] or localized non-melanoma skin cancer
* Stage V kidney disease or on renal-replacement therapy
* Neutropenia (\<1,500/mm3 or \<1,000/mm3 in African-American patients)
* Pregnancy or breastfeeding
* Angina, hypertension, arrhythmias, electrocardiograph (ECG) changes, or other non-cardiac limitations that limit 6MWD obtained during the baseline testing
* Hypersensitivity to anakinra or to E. coli derived products DRUG: Anakinra
Heart Failure
Inotrope sensitivity, IL-1 Blockade, Subcutaneous (SC), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV, 6 Minute Walk Test (6MWT)
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Study Locations
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| Location | Contacts |
|---|---|
| Virginia Commonwealth University Henrico, Virginia | Azita Talasazah - (talasazah@vcu.edu) Benjamin Van Tassell - (bvantassell@vcu.edu) |
ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack (ARTEMIS)
Novo Nordisk - clinicaltrials@novonordisk.com
NCT06118281
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Key inclusion:
* Age 18 years or above at the time of signing the informed consent.
* Hospitalisation for acute myocardial infarction with evidence of type 1 myocardial infarction (MI) by invasive angiography performed at site with percutaneous coronary intervention (PCI) capabilities.
* ST-segment elevation myocardial infarction (STEMI) with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 12 hours before hospitalisation, at the investigator's discretion.
b) Electrocardiogram (ECG)-changes (in the absence of left ventricular hypertrophy or left bundle branch block): ST-segment elevation at the J point in at least two contiguous leads greater than or equal 0.25 (millivolt) mV in men less than 40 years, greater than or equal 0.2 mV in men greater than or equal 40 years, or greater than or equal 0.15 mV in women in leads V2-V3; and/or greater than or equal 0.1 mV in all other leads.
OR
* Non-ST-segment myocardial infarction with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 24 hours before hospitalisation, at the investigator's discretion. b) Rise and/or fall in car-diac troponin I or T with at least one value above the 99th percentile upper reference limit.
* Possibility for both randomisation and administration of the loading dose of study intervention as early as possible after invasive procedure, and latest within 36 hours of hospitalisation (time 0) for STEMI, and latest within 72 hours of hospitalisation (time 0) for NSTEMI.
* Presence of at least one of the following criteria confirmed based on the participant's medical records and/or medical history interview: a) Any prior MI. b) Prior coronary revascularisation. c) Diabetes mellitus treated with ongoing glucose-lowering agent(s). d)Known chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) greater than or equal to 15 and less than 60 milliliter per minute per 1.73 square meter (mL/min/1.73 m\^2). e) Prior ischaemic stroke. f) Known carotid disease or peripheral artery disease in the lower extremities. g) Multivessel coronary artery disease (current/prior). h) For STEMI patients only: anterior MI at index acute myocardial infarction (AMI)
Key exclusion:
* Use of fibrinolytic therapy for treatment of the current AMI.
* Chronic heart failure classified as being in New York Heart Association (NYHA) Class IV.
* Ongoing haemodynamic instability defined as any of the following: a) Killip Class III or IV. b) Sustained and/or symptomatic hypotension (systolic blood pressure less than 90 millimeters of mercury (mmHg)).
* Severe kidney impairment defined as any of the following: a) eGFR less than 15 mililitre per minute per 1.73 m\^2. b) Chronic haemodialysis or peritoneal dialysis.
* Known alanine aminotransferase (ALT) greater than 8 x upper limit of normal (reference range) (ULN).
* Severe hepatic disease defined as at least one of the following: a) Previously known or current hepatic encephalopathy (clinical evaluation). b) Previously known or current ascites (clinical eval-uation). c) Jaundice (clinical evaluation). d) Previous oesophageal/gastric variceal bleeding. c) Known hepatic cirrhosis.
* Major cardiac surgical (including but not restricted to coronary artery bypass graft surgery (CABG)), non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days or any major surgical procedure planned at the time of randomisation or as treatment for the current AMI (CABG). Deferred (staged)percutaneous coronary intervention for a non-culprit vessel identified during the current AMI is allowed.
* Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
* Known (acute or chronic) hepatitis B or hepatitis C.
* History or evidence of untreated latent tuberculosis (TB) such as (but not limited to): a) History of a positive TB test or chest X-ray compatible with latent TB; and TB treatment initiated less than 28 days prior to randomisation. b) Participants with TB risk factors but unwilling to undergo TB treatment if confirmed positive for latent TB based on central laboratory test at baseline (visit 2).
DRUG: Ziltivekimab, DRUG: Placebo
Cardiovascular Risk, Acute Myocardial Infarction (AMI)
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Show 970 locations
Study Locations
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| Location | Contacts |
|---|---|
| "AHEPA" University General Hospital of Thessaloniki Thessaloniki, | |
| "AHEPA" University General Hospital of Thessaloniki Thessaloniki, | |
| "Hygeia" General Hospital of Athens Athens, | |
| "Sotiria" Thoracic Diseases Hospital of Athens Athens, | |
| "UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology Sofia, | |
| 'G. Gennimatas' General Hospital of Athens Athens, | |
| 'G. Gennimatas' General Hospital of Athens - Cardiology Department Athens, | |
| 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ Lublin, | |
| 10 Wojskowy Szpital Kliniczny z Poliklinika - Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Bydgoszczy Bydgoszcz, | |
| 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu Wroclaw, | |
| A.O.U Città della Salute e della Scienza di Torino Torino, | |
| A.O.U Città della Salute e della Scienza di Torino Torino, | |
| A.O.U. Ferrara, Sant'Anna Cona (Ferrara), Fe | |
| AORN "Sant'Anna e San Sebastiano" Caserta, Ce | |
| AOU Maggiore della Carità di Novara - Dipartimento Toraco-Cardio-Vascolare - SCDU Cardiologia Novara, | |
| AOUI Verona Verona, | |
| AOUI Verona Verona, | |
| ASSOCIAÇÃO LAR SÃO FRANCISCO DE ASSIS NA PROVIDÊNCIA DE DEUS - Hospital Regional de Presidente Prudente Presidente Prudente, São Paulo | |
| AUSL Romagna - Distretto Rimini - Ospedale Infermi Rimini, | |
| AUSL Toscana Sud Est - Ospedale Misericordia Grosseto Grosseto, | |
| Aakash Healthcare Super Speciality Hospital New Delhi, | |
| Aalborg Universitetshospital Hjertemedicinsk Afdeling Gistrup, | |
| Aalborg Universitetshospital Kardiologisk Afdeling Aalborg, | |
| Aarhus Universitetshospital, Hjertesygdomme Aarhus N, | |
| Abbott Northwestern Hospital Minneapolis, Minnesota | |
| Acibadem City Clinic UMHAT EOOD, Cardiology Sofia, | |
| Acibadem City Clinic UMHAT Tokuda EAD, Cardiology Sofia, | |
| Adana Şehir Eğitim ve Araştırma Hastanesi Adana, | |
| Adrian Costa Clinical Trials Centre Geelong, Victoria | |
| Advanced Cardiovascular, LLC Alexander City, Alabama | |
| Advanced Heart & Vein Center Thornton, Colorado | |
| Advanced Heart Care LLC Bridgewater, New Jersey | |
| Adventist Healthcare Shady Grove Medical Center Rockville, Maryland | |
| Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji Afyonkarahisar, | |
| Ajou University Hospital Suwon, Gyeonggi-do | |
| Akdeniz Üniversitesi Hastanesi-Kardiyoloji Antalya, | |
| Alexandra General Hospital, Therapeutic Clinic Athens, | |
| All India Institute of Medical Sciences (AIIMS) New Delhi, | |
| All India Institute of Medical Sciences (AIIMS) New Delhi, | |
| All India Institute of Medical Sciences (AIIMS), Bhubaneswar Bhubaneswar, Odisha | |
| All India Institute of Medical Sciences (AIIMS), Nagpur Nagpur, Maharashtra | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| Amper Kliniken AG - Helios Amper-Klinikum Dachau - Kardiologie Dachau, | |
| Amphia Ziekenhuis Breda, | |
| AnMed Health Clinical Research Anderson, South Carolina | |
| Ankara Bilkent Şehir Hastanesi-Kardiyoloji Ankara, | |
| Ankara Sehir Hastanesi Cardiology Ankara, | |
| Ankara Üniversitesi Tıp Fakültesi İbni Sina Hastanesi- Kardiyoloji Ankara, Altindag | |
| Antalya Eğitim ve Araştırma Hastanesi- Kardiyoloji Muratpasa/ Antalya, | |
| Ap-Hp-Hopital Bichat-Claude Bernard Paris, | |
| Ap-Hp-Hopital Europeen Georges Pompidou Paris, | |
| Aphp-Hopital La Pitie Salpetriere Paris, | |
| Apollo Multispeciality Hospital, Kolkata Kolkata, West Bengal | |
| Apollo Multispeciality Hospital, Kolkata Kolkata, West Bengal | |
| Arcispedale S Maria Nuova Azienda ULSS-IRCCS Reggio Emilia, | |
| Arkansas Cardiology Clinic Little Rock, Arkansas | |
| Arneja Heart & Multispeciality Hospital Nagpur, Maharashtra | |
| Asahi General Hospital＿Cardiology Chiba, | |
| Asan Medical Center Seoul, | |
| Ascension Sacred Heart Pensacola, Florida | |
| Ascension St. Mary's Research Institute - Michigan Southfield, Michigan | |
| Asklepieion General Hospital - Cardiology Clinic Athens/Voula, | |
| Asklepios Klinik Langen - Medizinische Klinik I Langen, | |
| Assistance Publique Hopitaux de Marseille-Hopital de La Timone Marseille, | |
| Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista Bragança Paulista, São Paulo | |
| Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital New Delhi, National Capital Territory of Delhi | |
| Atlanta VAMC Decatur, Georgia | |
| AtlantiCare Regional Medical Center Pomona, New Jersey | |
| Augusta University Augusta, Georgia | |
| Augusta University Augusta, Georgia | |
| Aultman Hospital Canton, Ohio | |
| Aurora St. Luke's Medi Ctr Milwaukee, Wisconsin | |
| Austin Heart San Marcos, Texas | |
| Austin Hospital Heidelberg, Victoria | |
| Azienda Ospedaliera Santa Maria Degli Angeli Pordenone, PN | |
| Azienda Ospedaliera Universitaria Careggi Florence, Tuscany | |
| Azienda Ospedaliera Universitaria Federico II di Napoli Naples, | |
| Azienda Ospedaliera di Parma Parma, | |
| Azienda Ospedaliera di Parma Parma, | |
| Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli Naples, | |
| Azienda Ospedaliero - Universitaria Sant'Andrea Rome, | |
| Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara Novara, | |
| Azienda Ospedaliero-Universitaria Renato Dulbecco Catanzaro, Cz | |
| Azienda Ospedaliero-Universitaria SS Antonio e Biagio e Cesare Arrigo Alessandria, | |
| Azienda Sanitaria Friuli Occidentale - Azienda Ospedaliera Santa Maria Degli Angeli - SC Cardiologia Pordenone Pordenone, PN | |
| Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia Torino, To | |
| Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia Torino, To | |
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Bergamo, Lombardy | |
| Azienda Unità Sanitaria Locale Di Piacenza - Cardiologia Piacenza, | |
| B M Birla Heart Research Centre Kolkata, West Bengal | |
| B M Birla Heart Research Centre Kolkata, West Bengal | |
| BG Klinikum Unfallkrankenhaus Berlin GmbH - Klinik für Kardiologie Berlin, | |
| Baptist Clin Res Institute Memphis, Tennessee | |
| Baptist Heart Specialists Jacksonville, Florida | |
| Baptist Hospital Cardiology Pensacola, Florida | |
| Barts Heart Centre London, | |
| Batra Hospital and Medical Research Center New Delhi, National Capital Territory of Delhi | |
| Batra Hospital and Medical Research Center New Delhi, National Capital Territory of Delhi | |
| Baylor Scott & White Res Inst Plano, Texas | |
| Beijing Anzhen Hospital, Capital Medical University Beijing, Beijing Municipality | |
| Beijing Anzhen Hospital, Capital Medical University Beijing, Beijing Municipality | |
| Bellvitge Universitary Hospital Badalona, | |
| Birmingham VA Medical Center Birmingham, Alabama | |
| Blackpool Victoria Hospital Blackpool, | |
| Bon Secours St. Mary's Hospital of Richmond, LLC Richmond, Virginia | |
| Bravis Zkh Roosendaal Roosendaal, | |
| Bremer Institut für Herz- und Kreislaufforschung (BIHKF) Bremen, | |
| Bridgeport Hospital Bridgeport, Connecticut | |
| Brigham & Women's Hospital Boston, Massachusetts | |
| Bursa Yüksek İhtisas Eğitim ve Araştırma Merkezi-Kardiyoloji Bursa, | |
| Bursa Şehir Hastanesi- Kardiyoloji Bursa, | |
| CHU de Quebec-Universite-Laval,HDQ Québec, | |
| CHUM Centre de Recherch Hotel-Dieu Montreal, Quebec | |
| CHUM Centre de Recherch Hotel-Dieu Montreal, Quebec | |
| CIP Centro Integrado de Pesquisas do Hospital de Base São José do Rio Preto, São Paulo | |
| CIP Centro Integrado de Pesquisas do Hospital de Base São José do Rio Preto, São Paulo | |
| CISSS de Lanaudiere - Centre hospitalier De Lanaudiere Saint-Charles-Borromée, Quebec | |
| CISSSL Hôsp Pierre-Le Gardeur Terrebonne, Quebec | |
| CIUSS Hopit de Chicoutimi Chicoutimi, Quebec | |
| CV Research of Knoxville Powell, Tennessee | |
| Cairns Base Hospital Cairns, Queensland | |
| Cangzhou Central Hospital Cangzhou Shi, Hebei | |
| Cangzhou Central Hospital Cangzhou Shi, Hebei | |
| Canisius-Wilhelmina ziekenhuis Nijmegen, | |
| Cardio. Consult. of S. GA Thomasville, Georgia | |
| Cardiolg Assoc Rsch LLC_Tupelo Tupelo, Mississippi | |
| Cardiolg Assoc Rsch LLC_Tupelo Tupelo, Mississippi | |
| Cardiology Associates of Fairfield County Stamford, Connecticut | |
| Cardiology Associates_Asheville Asheville, North Carolina | |
| Cardiología Hospital J. M. Ramos Mejia Buenos Aires, | |
| Cardiovascular Associates of the Delaware Valley Sewell, New Jersey | |
| Catharina Zkh Eindhoven - Cardiologie Eindhoven, | |
| Cellitinnen-Krankenhaus St. Vinzenz Köln - Kardiologie Cologne, | |
| Central Arkansas Veteran's Healthcare System Little Rock, Arkansas | |
| Central India Cardiology Hospital and Research Institute Nagpur, Maharashtra | |
| Centre Hospitalier Regional Universitaire de Tours-Hopital Trousseau Chambray-lès-Tours, | |
| Centre Hospitalier Saint Joseph Saint Luc Lyon, | |
| Centre Hospitalier Sud Francilien Corbeil-Essonnes, | |
| Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon Grenoble, | |
| Centre Hospitalier Universitaire de Besancon-Hopital Jean Minjoz Besançon, | |
| Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque Pessac, | |
| Centre Hospitalier Universitaire de Caen Normandie- Cote de Nacre Caen, | |
| Centre Hospitalier Universitaire de Lille-Institut Coeur Poumon Lille, | |
| Centre Hospitalier Universitaire de Nice-Hopital Pasteur Nice, | |
| Centre Hospitalier Universitaire de Poitiers Poitiers, | |
| Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil Toulouse, | |
| Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1 Toulouse, | |
| Centre hosp affilié univ rég Trois-Rivières, Quebec | |
| Centro Médico Nacional Siglo XXI Mexico City, | |
| Centro Privado de Cardiología San Miguel de Tucuimán, Tucumán Province | |
| Centro de Atención e Investigación Cardiovascular del Potosi (CICAP) San Luis Potosí City, | |
| Centro de Estudios Clinicos de Querétaro S.C. Querétaro, | |
| Centro de Estudios Clinicos de Querétaro S.C. Querétaro, | |
| Centro de Imagen y Tecnologia en Intervención Cardiovascular México, La Magdalena Contreras | |
| Centro de Investigación C.I.C.E 9 de Julio - Sanatorio 9 de Julio San Miguel de Tucumán, Tucumán Province | |
| Centro de Pesquisa Clínica do Hospital de Clínicas da Universidade Federal de Uberlândia Uberlândia, Minas Gerais | |
| Centro de atención e investigación cardiovascular del Potosí San Luis Potosí City, | |
| Cerrahpaşa Kardiyoloji Enstitüsü Istanbul, | |
| Chambersburg Hospital Chambersburg, Pennsylvania | |
| Chambersburg Hospital Chambersburg, Pennsylvania | |
| Charité - Campus Benjamin Franklin - Klinik für Kardiologie Berlin, | |
| Chattanooga Heart Institute Chattanooga, Tennessee | |
| Chattanooga Heart Institute Chattanooga, Tennessee | |
| China-Japan Friendship Hospital Beijing, | |
| China-Japan Friendship Hospital Beijing, | |
| China-Japan Union Hospital of Jilin University Changchun, Jilin | |
| China-Japan Union Hospital of Jilin University-Cardiology Changchun, Jilin | |
| Chinese Academy of Medical Sciences Fuwai Hospital Beijing, Beijing Municipality | |
| Chippenham Medical Center Richmond, Virginia | |
| Chonnam National University Hospital Gwangju, | |
| Chopda Medicare and Research Centre Pvt. Ltd. Nashik, Maharashtra | |
| Christiana Care Health Services, Inc. Newark, Delaware | |
| Christus Heart and Vascular Institute Tyler, Texas | |
| Chru de Nancy - Hopital Brabois Vandœuvre-lès-Nancy, | |
| Chungbuk National University Hospital Cheongju-si, | |
| Chungnam National University Hospital Daejeon, | |
| Chungnam National University Hospital Daejeon, | |
| Chungnam National University Sejong Hospital Sejong-si, | |
| Cleveland Clinic_Cleveland Cleveland, Ohio | |
| Clínica Privada Velez Sarsfield Córdoba, | |
| Clínica Privada Velez Sarsfield Córdoba, | |
| Colorado Heart and Vascular PC Golden, Colorado | |
| Complejo Hospitalario Universitario A Coruna A Coruña, | |
| Complejo Hospitalario Universitario A Coruna A Coruña, | |
| Concord Repatriation General Hospital - Cardiology Department Concord, New South Wales | |
| Copernicus Podmiot Leczniczy Sp. z o.o. Gdansk, | |
| Corewell Health Grand Rapids, Michigan | |
| Dallas VA Medical Center Dallas, Texas | |
| Danbury Hospital - Cardiology Department Danbury, Connecticut | |
| Dartmouth-Hitchcock Med Ctr Lebanon, New Hampshire | |
| Dayanand Medical College & Hospital Ludhiana, Punjab | |
| Dayanand Medical College & Hospital Ludhiana, Punjab | |
| Deenanath Mangeshkar Hospital & Research Centre Pune, | |
| Deenanath Mangeshkar Hospital & Research Centre Pune, | |
| Denver Health Medical Center Denver, Colorado | |
| Derriford Hospital - Plymouth Plymouth, | |
| Deutsches Herzzentrum TU München - Klinik für Herz- und Kreislauferkrankungen München, | |
| Dolnoslaski Szpital Specjalistyczny Im. T.Marciniaka-Centrum Medycyny Ratunkowej Wroclaw, | |
| Dr. Ram Manohar Lohia Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Dr. Ram Manohar Lohia Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji Istanbul, | |
| Duke University Medical Center Durham, North Carolina | |
| ESIC Medical College and Hospital, Hyderabad Hyderabad, Telangana | |
| Eastern Shore Rsrch Inst, LLC Fairhope, Alabama | |
| Ehime Prefectural Central Hosp Ehime, | |
| Elisabeth-TweeSteden Ziekenhuis Tilburg, North Brabant | |
| Emory University Hospital Atlanta, Georgia | |
| Endeavor Health Glenbook Hosp Evanston, Illinois | |
| Ente Ecclesiastico Ospedale Generale Regionale Miulli - Cardiologia e UTIC Acquaviva delle Fonti, | |
| Erciyes University Cardiology Kayseri, | |
| Erciyes Üniversitesi Hastanesi- Kardiyoloji Kayseri, | |
| Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji Eskişehir, | |
| Eskişehir Şehir Hastanesi- Kardiyoloji Eskişehir, | |
| Essentia Health Duluth, Minnesota | |
| Evangelismos Hospital Athens, | |
| Ewha Womans University Seoul Hospital Seoul, | |
| FN u Sv. Anny Brno, | |
| FN u Sv. Anny Brno, | |
| Fairview Health Services Maplewood, Minnesota | |
| Fairview Health Services Maplewood, Minnesota | |
| Fakultni nemocnice Brno Brno, | |
| Fakultni nemocnice Kralovske Vinohrady Prague, | |
| Fakultni nemocnice Olomouc Olomouc, | |
| Fakultni nemocnice Plzen - Lochotin Plzen - Lochotín, | |
| Flinders Medical Centre Bedford PK, South Australia | |
| Fondazione IRCCS Policlinico San Matteo Pavia, | |
| Fondazione IRCCS San Gerardo dei Tintori Monza, | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCS Roma, | |
| Fondazione Policlinico Universitario Agostino Gemelli Irccs Roma, | |
| Fortis Escorts Heart Institute, New Delhi New Delhi, National Capital Territory of Delhi | |
| Fortis Hospital, Mohali Mohali, Punjab | |
| Fortis Hospital, Mohali Mohali, Punjab | |
| Freeman Hospital, Newcastle Newcastle upon Tyne, | |
| Fujita Health University Hospital_Cardiology Aichi, | |
| Fujita Health University Hospital_Cardiology Aichi, | |
| Fukuoka University Hospital_Cardiology Fukuoka-shi, Fukuoka, | |
| Fukuoka University Hospital_Cardiology Fukuoka-shi, Fukuoka, | |
| Fundacion Favaloro CABA, Buenos Aires, Argentina | |
| Fundación Nuestra Señora del Rosario - Estudios Clínicos los Arroyos San Nicolás de los Arroyos, Buenos Aires | |
| G B Pant Institute of Postgraduate Medical Education and Research New Delhi, National Capital Territory of Delhi | |
| G. Kuppuswamy Naidu Memorial Hospital Coimbatore, Tamil Nadu | |
| G. Kuppuswamy Naidu Memorial Hospital Coimbatore, Tamil Nadu | |
| G.H. of Athens "Evaggelismos" Athens, | |
| Gachon University Gil Medical Center Incheon, Namdong-gu | |
| Ganesh Shankar Vidyarthe Memorial (GSVM) Medical College Kanpur, Uttar Pradesh | |
| Geisinger Medical Center Danville, Pennsylvania | |
| Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt Thessaloniki, | |
| General Hospital Of Eleusina Thriasio - Cardiology Clinic Eleusina, | |
| General Hospital Of Patras Agios Andreas - Cardiology Department Pátrai, | |
| General Hospital of Athens "Elpis" - Cardiology Department Ampelokipoi/Athens, | |
| General Hospital of Athens "Laiko" Athens, Attikí | |
| General Hospital of Chios "Skilitsio" - Cardiology Clinic Chios, | |
| General Hospital of Imathia Monada Veria Véroia, | |
| General Hospital of Imathia Monada Veria - Cardiology Department Véroia, | |
| General Hospital of Thessaloniki PAPAGEORGIOU Nea Efkarpia, Thessaloniki | |
| General Hospital of Tianjin Medical University-Endocrinology Tianjin, Tianjin Municipality | |
| Genesis Health Care System Zanesville, Ohio | |
| Geniko Nosokomeio Peiraia Tzaneio - Cardiology department Piraeus, | |
| Glenfield Hospital Leicester, | |
| Gold Coast University Hospital - Cardiology Department Southport, Queensland | |
| Gold Coast University Hosptial Southport, Queensland | |
| Golden Jubilee University National Hospital Glasgow, | |
| Grande Ospedale Metropolitano Niguarda Milan, | |
| Grandview Medical Center Birmingham, Alabama | |
| Grey Nuns Community Hospital Edmonton, Alberta | |
| Groene Hart Zkh Gouda - Cardiologie Gouda, | |
| Group Euroclinic - Athens Euroclinic - Cardiology Department Athens, | |
| Guangdong Provincial People's Hospital Guangzhou, | |
| Guangdong Provincial People's Hospital Guangzhou, | |
| H. Clinico Univ. Virgen de la Victoria, Malaga Málaga, | |
| HCA Research Institute McAllen, Texas | |
| HMC, locatie Westeinde - Cardiologie The Hague, | |
| Hackensack Meridian Health Hackensack, New Jersey | |
| Hadassah Ein Karam MC - Cardio Department Jerusalem, | |
| Hadassah Mount Scorpus MC - Cardiology department Jerusalem, | |
| Hamilton Health Sciences Corp, Ontario Hamilton, Ontario | |
| Hanaoka Seishu Memorial Hosp._Cardiovascular Medicine Hokkaido, | |
| Hanaoka Seishu Memorial Hospital Hokkaido, | |
| Hanyang University Seoul Hospital Seoul, | |
| Harefield Hospital Harefield, Middlesex | |
| Health Sciences North Rsrch Inst Greater Sudbury, Ontario | |
| Heart & Vascular Inst._Titus Mount Pleasant, Texas | |
| Heart Center Rsrch_Hunstville Huntsville, Alabama | |
| Hebei General Hospital Shijiazhuang, Hebei | |
| Helios Klinikum Erfurt GmbH - 3. Med. Klinik - Kardiologie Erfurt, | |
| Henry Dunant Hospital Center Athens, | |
| Heritage Medical Research Clinic Calgary, Alberta | |
| Herlev og Gentofte Hospital Hellerup, Capital Region | |
| Hermosillo Heart Team Hermosillo, Sonora | |
| Hillel Yaffe MC - Cardiology Department Hadera, | |
| Hippokration Hospital Athens, | |
| Holy Cross Hospital Silver Spring, Maryland | |
| Holy Name Medical Center Teaneck, New Jersey | |
| Honor Health Scottsdale, Arizona | |
| Hopital Sacre-Coeur de Montreal Montreal, Quebec | |
| Hospices Civils de Lyon- Hopital Louis Pradel Bron, | |
| Hospital Agamenon Magalhães Recife, Pernambuco | |
| Hospital Agamenon Magalhães Recife, Pernambuco | |
| Hospital Alvaro Cunqueiro de Vigo Vigo, | |
| Hospital Angeles de Culiacan Culiacán, Sinaloa | |
| Hospital Angeles de Xalapa Xalapa, Veracruz | |
| Hospital Angeles de las Lomas México, State of Mexico | |
| Hospital Canselor Tuanku Muhriz UKM Cheras, | |
| Hospital Cardiologica Aguascalientes Aguascalientes, Aguascalientes | |
| Hospital Civil De Guadalajara Fray Antonio Alcalde Guadalajara, Jalisco | |
| Hospital Clinic i Provincial Barcelona, | |
| Hospital Clinico San Carlos Madrid, | |
| Hospital Clinico Universitario de Valencia Valencia, | |
| Hospital Clinico Universitario de Valladolid Valladolid, | |
| Hospital Clinico de Santiago Santiago de Compostela, | |
| Hospital Clinico de Santiago Santiago de Compostela, | |
| Hospital De La Santa Creu I Sant Pau Barcelona, | |
| Hospital De La Santa Creu I Sant Pau Barcelona, | |
| Hospital Del Mar Barcelona, | |
| Hospital Del Mar Barcelona, | |
| Hospital Dr. Jose Maria Cullen Santa Fe, | |
| Hospital Espanol De Mendoza Mendoza, | |
| Hospital Espanol De Mendoza Mendoza, | |
| Hospital General Universitario Dr. Balmis Alicante, | |
| Hospital General de Mexico (HGM) Cuauhtémoc, Mexico City | |
| Hospital Germans Trias I Pujol Badalona, | |
| Hospital Germans Trias I Pujol Badalona, | |
| Hospital Gral Alicante Dr. Balmis Alicante, | |
| Hospital Gregorio Maranon Madrid, | |
| Hospital Gregorio Maranon Madrid, | |
| Hospital Israelita Albert Einstein Morumbi, São Paulo | |
| Hospital Italiano Buenos Aires, | |
| Hospital Italiano de la Plata La Plata, Buenos Aires | |
| Hospital Juárez de Mexico Ciudad de México, D.F., | |
| Hospital Juárez de Mexico Ciudad de México, D.F., | |
| Hospital Maternidade e Pronto Socorro Santa Lucia Poços de Caldas, Minas Gerais | |
| Hospital Mãe de Deus - Porto Alegre Porto Alegre/RS, | |
| Hospital Pulau Pinang George Town, Pulau Pinang | |
| Hospital Queen Elizabeth II Kota Kinabalu, | |
| Hospital Raja Perempuan Zainab II Kelantan, | |
| Hospital Raja Permaisuri Bainun Ipoh Ipoh, Perak | |
| Hospital Ramon Y Cajal Madrid, | |
| Hospital Ruy Azeredo Ltda Goiânia, Goiás | |
| Hospital Serdang Kajang, Selangor | |
| Hospital Serdang Kajang, Selangor | |
| Hospital Sultanah Aminah Johor Bahru, | |
| Hospital Sultanah Bahiyah Alor Setar, Kedah, | |
| Hospital São Lucas - PUC/RS Porto Alegre, Rio Grande do Sul | |
| Hospital Tengku Ampuan Afzan Kuantan, Pahang | |
| Hospital Univ. Virgen de la Arrixaca El Palmar, | |
| Hospital Universitari Joan XXIII Tarragona, | |
| Hospital Universitari Joan XXIII Tarragona, | |
| Hospital Universitario Austral Pilar, | |
| Hospital Universitario Austral - Instituto de Cardiologia Pilar, Buenos Aires | |
| Hospital Universitario Dr. Jose Eleuterio Gonzalez Monterrey, Nuevo León | |
| Hospital Universitario La Paz Madrid, | |
| Hospital Universitario Marqués de Valdecilla Santander, | |
| Hospital Universitario Virgen del Rocio Seville, | |
| Hospital Universitario de La Princesa Madrid, | |
| Hospital Universiti Kebangsaan Malaysia Kuala Lumpur, | |
| Hospital Universiti Sains Malaysia_Kota Bharu, Kelantan Kota Bharu, Kelantan, | |
| Hospital Virgen de la Arrixaca El Palmar, Murcia | |
| Hospital das Clínicas da Universidade Federal do Triangulo Mineiro Uberaba, Minas Gerais | |
| Hospital de Lleida "Arnau de Vilanova" Lleida, | |
| Hospital del Centenario Rosario, Santa Fe, Santa Fe Province | |
| Hospital do Coração do Brasil Brasília, Federal District | |
| Houston Medical Center Houston, Texas | |
| Houston Medical Center Houston, Texas | |
| Houston Methodist Hospital Houston, Texas | |
| Huashan Hospital Fudan University Shanghai, | |
| Huashan Hospital Fudan University Shanghai, | |
| Hyogo Medical University Hospital_Cardiovascular Medicine Hyōgo, | |
| Hyogo Medical University Hospital_Cardiovascular Medicine Hyōgo, | |
| Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology Himeji-shi, Hyogo, | |
| Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology Himeji-shi, Hyogo, | |
| ICOT Istituto Marco Pasquali - UOC Cardiologia Latina, Lazio | |
| ICOT Istituto Marco Pasquali - UOC Cardiologia Latina, Lazio | |
| II. interni klinika VFN - Kardiologie a angiologie Prague, | |
| IKEM Prague, | |
| IRCCS Policlinico San Donato San Donato Milanese, MI | |
| Ikazia Ziekenhuis Rotterdam, | |
| Illawarra Heart Health Centre Wollongong, New South Wales | |
| Indiana University Health Methodist Hospital Indianapolis, Indiana | |
| Indraprastha Apollo Hospital, New Delhi New Delhi, National Capital Territory of Delhi | |
| Indraprastha Apollo Hospital, New Delhi New Delhi, National Capital Territory of Delhi | |
| Inha University Hospital Incheon, | |
| Inje University Haeundae Paik Hospital Busan, | |
| Inova Fairfax Medical Campus, Falls Church Fairfax, Virginia | |
| Ins Uni de Cardi et de PNA de Québec, | |
| Inspira Health - Cardiology Mullica Hill, New Jersey | |
| Instituto Cardiovascular Buenos Aires CABA, Buenos Aires | |
| Instituto Dante Pazzanese de Cardiologia São Paulo, São Paulo | |
| Instituto Nacional de Cardiologia Ignacio Chavez Mexico City, | |
| Instituto Nacional de Ciencias Medicas y Nutricion Tlalpan, Mexico City | |
| Instituto Nacional de Ciencias Medicas y Nutricion Tlalpan, Mexico City | |
| Instituto de Cardiología de Corrientes Corrientes, | |
| Instituto de Pesquisa Clinica de Campinas Campinas, São Paulo | |
| Integral Pesquisa e Ensino Votuporanga, São Paulo | |
| Integral Pesquisa e Ensino Votuporanga, São Paulo | |
| Interbalkan Medical Center of Thessaloniki Thessaloniki, | |
| Intercard Spolka z ograniczona odpowiedzialnoscia Krosno, | |
| Intercard Spolka z ograniczona odpowiedzialnoscia Krosno, | |
| Intercoastal Medical Group Sarasota, Florida | |
| Intercoastal Medical Group Sarasota, Florida | |
| Intermountain Medical Center Murray, Utah | |
| Interventional Cardiology Medical Group West Hills, California | |
| Irmandade Santa Casa de Misericórdia de Passos Passos, Minas Gerais | |
| Irmandade da Santa Casa de Misericordia de Porto Alegre Porto Alegre, | |
| Irmandade da Santa Casa de Misericórdia de Marília Marília, São Paulo | |
| Ishikawa Prefectural Central Hospital_Cardiology Ishikawa, | |
| Ishikawa Prefectural Central Hospital_Cardiology Ishikawa, | |
| Ishikiriseiki Hospital_Circulatory Medicine Osaka, | |
| Istanbul University Cerrahpasa Medical Faculty Istanbul, Bakirkoy | |
| Jackson Heart Clinic Jackson, Mississippi | |
| Jacobi Medical Center The Bronx, New York | |
| Jacobi Medical Center The Bronx, New York | |
| Jadestone Clinical Research, LLC Silver Spring, Maryland | |
| Japanese Red Cross Fukuoka Hospital_Cardiology Fukuoka, | |
| Japanese Red Cross Fukuoka Hospital_Cardiology Fukuoka, | |
| Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry, Tamil Nadu | |
| Jawaharlal Nehru Medical College and Hospital Aligarh, Uttar Pradesh | |
| Jawaharlal Nehru Medical College and Hospital Aligarh, Uttar Pradesh | |
| Jeroen Bosch Zkh 's-Hertogenbosch, | |
| Jersey City Med Center Jersey City, New Jersey | |
| Jinan Central Hospital Jinan, | |
| Jmf Clínica Do Coração Ltda Aracaju, | |
| Juntendo University Shizuoka Hospital Izunokuni-shi, Shizuoka, | |
| Juntendo University Shizuoka Hospital_Gastroenterology & Hepatology Izunokuni-shi, Shizuoka, | |
| Justice K S Hegde Charitable Hospital Mangaluru, Karnataka | |
| Kagawa Prefectural Central Hospital_Cardiovascular Medicine Takamatsu-shi, Kagawa, | |
| Kaiser Permanente Viewridge Medical Offices San Diego, California | |
| Kanto Rosai Hospital_Cardiology Kanagawa, | |
| Kanto Rosai Hospital_Cardiology Kanagawa, | |
| Kaplan MC - Cardiac Intensive Care Rehovot, | |
| Kartal Kosuyolu Yuksek Ihtisas EAH Istanbul, | |
| Kasturba Medical College and Hospital, Manipal Udupi, Karnataka | |
| Kat Attica General Hospital - Cardiology Department Kifissia, | |
| Kath. St. Paulus GmbH - St Johannes Hospital Dortmund - Kardiologie Dortmund, | |
| Kayseri City Hospital Kayseri, | |
| Kayseri Şehir Hastanesi-Kardiyoloji Kayseri, | |
| Keimyung University Dongsan Hospital Daegu, | |
| Kelowna Cardiology Res. Ltd. Kelowna, British Columbia | |
| Kettering General Hospital Kettering, | |
| Kettering Medical Center Kettering, Ohio | |
| King George Hospital Visakhapatnam, Andhra Pradesh | |
| King George's Medical University (KGMU) Lucknow, Uttar Pradesh | |
| King George's Medical University (KGMU) Lucknow, Uttar Pradesh | |
| King's College Hospital - Cardiology London, | |
| Kings College Hospital London, | |
| Kingston General Hospital Kingston, Ontario | |
| Kingston General Hospital Kingston, Ontario | |
| Kliniczny Szpital Wojewodzki nr 2 im. Sw. Jadwigi Krolowej w Rzeszowie Rzeszów, | |
| Klinikum Friedrichshafen GmbH - Klinik für Kardiologie, Angiologie, Pneumologie und internistische Intensivmedizin Friedrichshafen, | |
| Klinikum Fulda gAG - Med. Klinik I Fulda, | |
| Klinikum Leverkusen gGmbH - Med. Klinik 1 Leverkusen, | |
| Knoxville Heart Group Knoxville, Tennessee | |
| Kocaeli Üniversitesi Hastanesi- Kardiyoloji Kocaeli, | |
| Konstantopouleio G.H. of Athens, "Agia Olga" Athens, | |
| Korea University Anam Hospital Seoul, | |
| Korea University Guro Hospital Seoul, | |
| Koşuyolu Yüksek İhtisas EAH- Kardiyoloji Istanbul, | |
| Krajska zdravotni, a.s. - Masarykova nemocnice v Usti nad Labem, o.z. Ústní Nad Labem, Czechia | |
| Krajská nemocice Liberec, a.s Liberec, | |
| Krajská nemocnice T.Bati a.s. Zlín, | |
| Kyung Hee University Hospital at Gangdong Seoul, | |
| Kyunghee University Medical Center Seoul, | |
| Kyungpook National University Hospital Daegu, | |
| Kütahya Sağlık Bilimleri Üniversitesi Evliya Çelebi EAH- Kardiyoloji Merkez/Kütahya, | |
| Kütahya Şehir Hastanesi-Kardiyoloji Kütahya, | |
| LA BioMed Harbor UCLA Med Cenr Torrance, California | |
| Lakshmi Hospital Palakkad, Kerala | |
| Lalitha PVS Institute of Medical Sciences Guntur, Andhra Pradesh | |
| Les Hopitaux de Chartres-Hopital Louis Pasteur Le Coudray, | |
| Lincoln County Hospital Lincoln, | |
| Lincoln County Hospital Lincoln, | |
| Lindner Center,Christ Hospital Cincinnati, Ohio | |
| Lisie Hospital Kochi, Kerala | |
| Lister Hospital Stevenage, | |
| Lister Hospital Stevenage, | |
| Liver Ins@ Mthdist DTX Med Cen Dallas, Texas | |
| Liverpool Heart & Chest Hospital Liverpool, | |
| Liverpool Hospital Liverpool, New South Wales | |
| Liverpool Hospital Liverpool, New South Wales | |
| Loma Linda University Faculty Medical Clinics Loma Linda, California | |
| London Health Sciences Center Ontario London, Ontario | |
| Louis Stokes Clvlnd VA Med Ctr Cleveland, Ohio | |
| Lyell McEwin Hospital Elizabeth Vale, South Australia | |
| Lyell McEwin Hospital Elizabeth Vale, South Australia | |
| MHAT "Dr. Bratan Shukerov" Smolyan, | |
| MHAT - Cardiolife OOD - Lovech Lovech, | |
| MHAT - City Clinic - Sveti Georgi EOOD Montana, | |
| MHAT - Dr. Atanas Dafovski AD, Cardiology department Kardzhali, | |
| MHAT - Ivan Skenderov EOOD Gotse Delchev, | |
| MHAT - Pazardzhik AD Pazardzhik, | |
| MHAT Dr. Bratan Shukerov Smolyan, | |
| MHAT Dr. Tota Venkova AD Gabrovo, | |
| MHAT Hadzhi Dimitar OOD Sliven, | |
| MHAT Haskovo AD Haskovo, | |
| MHAT Heart and Brain EAD - Burgas, Cardiology Burgas, | |
| MHAT Heart and Brain EAD - Pleven, Cardiology Pleven, | |
| MHAT MC-Sv Ivan Rilski EOOD Plovdiv, | |
| MHAT National Cardiology Hospital EAD Sofia, | |
| MHAT Puls AD, Cardiology Department Blagoevgrad, | |
| MHAT Southwest Hospital OOD, Cardiology Department Sandanski, | |
| MHAT Sveta Karidad EAD Plovdiv, | |
| MVZ CCB Frankfurt Und Main-Taunus GbR Frankfurt, | |
| Maasstad Ziekenhuis - Cardiologie Rotterdam, | |
| Maine Medical Center Bramhall Scarborough, Maine | |
| Malla Reddy Narayana Multispeciality Hospital Hyderabad, Telangana | |
| Malla Reddy Narayana Multispeciality Hospital Hyderabad, Telangana | |
| Marengo CIMS Hospital Ahmedabad, Gujarat | |
| Marmara University Medical Faculty Istanbul, | |
| Marmara Üniversitesi Pendik EAH- Kardiyoloji Istanbul, | |
| Matsuyama Red Cross Hospital_Department of Cardiovascular Medicine Ehime, | |
| Max Super Speciality Hospital, Saket New Delhi, National Capital Territory of Delhi | |
| Mayo Clinic Arizona Phoenix, Arizona | |
| Mayo Clinic Jacksonville Jacksonville, Florida | |
| McGuire VA Medical Center Richmond, Virginia | |
| McLaren Bay Region Bay City, Michigan | |
| McLaren Greater Lansing Lansing, Michigan | |
| McLaren Macomb Health Care Mount Clemens, Michigan | |
| McLaren Northern MI Hosp Petoskey, Michigan | |
| Meander MC Amersfoort, | |
| MedStar Hlth Res Institute Clinton, Maryland | |
| MedStar Hlth Res Institute Clinton, Maryland | |
| Medical College & Hospital, Kolkata Kolkata, West Bengal | |
| Medical College & Hospital, Kolkata Kolkata, West Bengal | |
| Medicover Hospitals, Visakhapatnam MVP Visakhapatnam, Andhra Pradesh | |
| Medisch Spectrum Twente - Cardiologie Enschede, | |
| Medizinische Hochschule Hannover - Kardiologie und Angiologie Hanover, | |
| Meir MC - Cardiology department Kfar Saba, | |
| Memorial Healthcare Owosso, Michigan | |
| Mercy Gilbert Medical Center Gilbert, Arizona | |
| Mercy Health - St. Vincent Medical Center Toledo, Ohio | |
| Mercy Research Springfield, Missouri | |
| MercyOne NE Iowa Fam Med & Res Waterloo, Iowa | |
| Mersin Üniversitesi Hastanesi- Kardiyoloji Mersin, | |
| Mersin Şehir Eğitim Araştırma Hastanesi- Kardiyoloji Mersin, | |
| Methodist Healthcare System of San Antonio San Antonio, Texas | |
| Methodist Healthcare System of San Antonio San Antonio, Texas | |
| Methodist Physicians Clinic Omaha, Nebraska | |
| MetroHealth Medical Center Cleveland, Ohio | |
| Metropolitan General Hospital Healthcare Facilities Operation And Management Single Member S.A. - Cardiology Clinic Athens, | |
| MidMic Medical Cntr - Midland Midland, Michigan | |
| Midwest Cardiovascu Rsrch Foundation Davenport, Iowa | |
| Midwest Heart and Vascular Specialists Overland Park, Kansas | |
| Midwest Heart and Vascular Specialists Overland Park, Kansas | |
| Miedziowe Centrum Zdrowia s.a. Lubin, | |
| Missouri Cardiovascular Specialist Columbia, Missouri | |
| Mito Saiseikai General Hospital_Cardiology Ibaraki, | |
| Mito Saiseikai General Hospital_Cardiology Ibaraki, | |
| Miyazaki Medical Association Hospital Miyazaki, Miyazaki | |
| Miyazaki Medical Association Hospital_Cardiology Miyazaki, Miyazaki | |
| Mobile Heart USA Health Cardiology Clinic Mobile, Alabama | |
| Monument Health Clinical Rsrch Rapid City, South Dakota | |
| Morriston Hospital Swansea, | |
| Moses H. Cone Mem Hosp Greensboro, North Carolina | |
| Mount Sinai Morningside New York, New York | |
| Multicare Health System Tacoma, Washington | |
| Multiprofile Hospital For Active Treatment Dr. Tota Venkova AD Gabrovo, | |
| Musgrove Park Hospital Taunton, Somerset | |
| Myongji Hospital Goyang-si, Gyeonggi-do | |
| NC Heart and Vascular Research Raleigh, North Carolina | |
| NHO Kure Medical Center and Chugoku Cancer Center Kure-shi, Hiroshima, | |
| NHO Kure Medical Center and Chugoku Cancer Center_Cardiology Kure-shi, Hiroshima, | |
| NIMTS Army Share Fund Hospital Athens, | |
| NUPEC Cardio Belo Horizonte, | |
| NYU Grossman School of Med New York, New York | |
| Nanfang Hospital, Southern Medical University Guangzhou, Guangdong | |
| Nanfang Hospital, Southern Medical University Guangzhou, Guangdong | |
| Nanjing Drum Tower Hospital Nanjing, | |
| Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy Warsaw, | |
| National Heart Institute Beverly Hills, California | |
| National Heart Institute Beverly Hills, California | |
| National Hospital Organization Kumamoto Medical Center_Cardiology Kumamoto, | |
| National Hospital Organization Kumamoto Medical Center_Cardiology Kumamoto, | |
| Necmettin Erbakan University Hospital Konya, | |
| Necmettin Erbakan Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji Konya, | |
| Nemocnice AGEL Třinec-Podlesí a.s. Třinec, | |
| Nemocnice Na Homolce Prague, | |
| Nemocnice Pardubickeho kraje a.s. Pardubice, | |
| Nemocnice České Budějovice a.s. České Budějovice, | |
| Nepean Hospital Kingswood, New South Wales | |
| New Brunswick Heart Centre Saint John, New Brunswick | |
| New Brunswick Heart Centre Saint John, New Brunswick | |
| New Cross Hospital Wolverhampton, | |
| Niagara Health System St. Catharines, Ontario | |
| Nil Ratan Sircar Medical College and Hospital Kolkata, West | |
| Nil Ratan Sircar Medical College and Hospital Kolkata, West | |
| Nishinomiya Watanabe Cardiovascular Cerebral Center_Cardiovascular Medicine Hyōgo, | |
| Noordwest Ziekenhuisgroep Alkmaar, | |
| Nordsjællands hospital - Kardiologisk Forskning Hillerød, | |
| North Kansas City Hospital Kansas City, Missouri | |
| North Mississippi Medical Center Tupelo, Mississippi | |
| Northeast Georgia Medical Ctr Gainesville, Georgia | |
| Northern General Hospital Sheffield, | |
| Northern General Hospital Sheffield, | |
| Northern Health Epping, Victoria | |
| Northern Light Eastern Maine Medical Center Bangor, Maine | |
| Novant Hlth Cardio - Kimel Park Winston-Salem, North Carolina | |
| Novant Hlth Vasc Ins Charlotte Charlotte, North Carolina | |
| Nuevo Hospital Civil "Dr. Juan I. Menchaca" Guadalajara, Jalisco | |
| Nuevo Hospital Civil "Dr. Juan I. Menchaca" Guadalajara, Jalisco | |
| OLVG Oost Amsterdam, | |
| OSF HealthCare_Cardiovasc Inst Rockford, Illinois | |
| Odense Universitetshospital, Kardiologisk afd. Odense C, | |
| Odense Universitetshospital, Kardiologisk afd. Odense C, | |
| Ondokuz Mayıs Üniversitesi Hastanesi- Kardiyoloji Samsun, | |
| Osaka General Medical Center_Cardiology Osaka, | |
| Osmania General Hospital Hyderabad, Telangana | |
| Osmania General Hospital Hyderabad, Telangana | |
| Ospedale Civile dell'Annunziata Cosenza, | |
| Ospedale Isola Tiberina Gemelli Isola Rome, | |
| Ospedale Maggiore Carlo Alberto Pizzardi Bologna, | |
| Ospedale Policlinico San Martino Genoa, Liguria | |
| Ospedale Sandro Pertini - UOC Cardiologia Rome, | |
| Ospedale Sant'Andrea - UOC Cardiologia La Spezia, | |
| Overton Brooks V.A. Medical Center Shreveport, Louisiana | |
| Overton Brooks V.A. Medical Center Shreveport, Louisiana | |
| PUCCAMP - Hospital e Maternidade Celso Pierro Campinas, São Paulo | |
| PUCCAMP - Hospital e Maternidade Celso Pierro Campinas, São Paulo | |
| Pan-Arcadian General Hospital of Tripoli Evangelistria - Cardiology Department Tripoli, | |
| Parkway Cardiology Associates, PC Oak Ridge, Tennessee | |
| Peking University First Hospital-Cardiology Beijing, Beijing Municipality | |
| Peking University First Hospital-Cardiology Beijing, Beijing Municipality | |
| Peking University Third Hospital Beijing, Beijing Municipality | |
| Peking University Third Hospital Beijing, Beijing Municipality | |
| Peninsula University Hospital - Cardiology Department Frankston, Victoria | |
| Penn State Hershey Medical Center Hershey, Pennsylvania | |
| Penn State Hlth Holy Spirit Med Ctr Camp Hill, Pennsylvania | |
| PharmaTex Research, LLC Amarillo, Texas | |
| Podhalanski Szpital Specjalistyczny Nowy Targ, | |
| Policlinico Casilino - Cardiologia e UTIC Rome, | |
| Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh Chandigarh, | |
| Prairie Cardiovascular Consultants, Ltd. Springfield, Illinois | |
| Presidio Ospedaliero di Rivoli Rivoli, To | |
| Prince of Wales Hospital - Sydney Randwick, New South Wales | |
| Princess Alexandra Hospital Woolloongabba, Queensland | |
| Princess Alexandra Hospital Woolloongabba, Queensland | |
| Prism Hlth Carolina Card Cons Greenville, South Carolina | |
| ProMedica Toledo, Ohio | |
| Prolato Clinical Research Cntr Houston, Texas | |
| Pusan National University Yangsan Hospital Yangsan, | |
| Pusan National University Yangsan Hospital Yangsan, | |
| QE II Health Sciences Centre Halifax, Nova Scotia | |
| QE II Health Sciences Centre Halifax, Nova Scotia | |
| Queen Alexandra Hospital Portsmouth, | |
| Queen Alexandra Hospital - Cardiology Portsmouth, | |
| Rabin MC -Beilinson - Cardiac intensive unit Petah Tikva, | |
| Radboudumc Nijmegen, | |
| Ramaiah Memorial Hospital Bengaluru, Karnataka | |
| Rambam MC - Cardiac Intensive Care Unit Haifa, | |
| Reading Hospital West Reading, Pennsylvania | |
| Regina General Hospital Regina, Saskatchewan | |
| Regions Hospital Saint Paul, Minnesota | |
| Reid Physician Associates Richmond, Indiana | |
| Renmin Hospital of Wuhan University-Cardiology Wuhan, Hubei | |
| Rhode Island Hospital Providence, Rhode Island | |
| Rhythm Heart Institute Vadodara, Gujarat | |
| Rhön-Klinikum AG - Zentralklinik Bad Berka - Kardiologie Bad Berka, | |
| Rigshospitalet - Kardiologisk Forskningsenhed København Ø, | |
| Rijnstate Ziekenhuis Arnhem, | |
| Robert Packer Hospital Sayre, Pennsylvania | |
| Robert-Bosch-Krankenhaus GmbH Stuttgart Stuttgart, | |
| Royal Adelaide Hospital - Cardiology Department Adelaide, South Australia | |
| Royal Adelaide Hospital Cardiovascular Clinical Trials Adelaide, South Australia | |
| Royal Alexandra Hospital Edmonton, Alberta | |
| Royal Bournemouth Hospital - Cardiology Bournemouth, Dorset | |
| Royal Brisbane and Women's Hospital Herston, Queensland | |
| Royal Brompton and Harefield Hospitals Harefield, Middlesex | |
| Royal Cornwall Hospital (Treliske) Truro, Cornwall | |
| Royal Infirmary of Edinburgh - Cardiology Edinburgh, | |
| Royal Perth Hospital Perth, Western Australia | |
| Royal University Hospital Saskatoon, Saskatchewan | |
| Royal Victoria Regional Health Centre Barrie, Ontario | |
| Royal Victoria Regional Health Centre Barrie, Ontario | |
| S Denver Cardiology Associates Littleton, Colorado | |
| S.P. Medical College & Associated Group of Hospitals Bikaner, | |
| S.P. Medical College & Associated Group of Hospitals Bikaner, | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCB Medical College and Hospital Cuttack, Odisha | |
| SHATC - Cardiolife OOD - Varna Varna, | |
| SHATC - Medica Kor EAD Rousse, | |
| SHATC - Yambol EAD Yambol, | |
| SMC Heart Institute and IVF Research Centre Raipur, Chhattisgarh | |
| SMS Medical College & Attached Hospitals Jaipur, Rajasthan | |
| SMS Medical College & Attached Hospitals Jaipur, Rajasthan | |
| Sahyadri Super Speciality Hospital Pune, | |
| Saint Elizabeth Medical Center Edgewood, Kentucky | |
| Saint Joseph's Hospital Health Center Liverpool, New York | |
| Saint Paul's Hospital Vancouver, British Columbia | |
| Saint Thomas Hospital Nashville, Tennessee | |
| Saiseikai Yokohamashi Nanbu Hospital_Cardiology Yokohama-shi, Kanagawa, | |
| Saiseikai Yokohamashi Nanbu Hospital_Cardiology Yokohama-shi, Kanagawa, | |
| Saiseikai Yokohamashi Tobu Hospital_Cardiology Kanagawa, | |
| Saiseikai Yokohamashi Tobu Hospital_Cardiology Kanagawa, | |
| Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II Grodzisk Mazowiecki, | |
| Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II Grodzisk Mazowiecki, | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie Rzeszów, | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie Krakow, | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Pulawach Puławy, Lublin Voivodeship | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Pulawach Puławy, Lublin Voivodeship | |
| Samodzielny Publiczny Zespol Opieki Zdrowotnej w Swidnicy Swidnica, | |
| Samodzielny Publiczny Zespol Opieki Zdrowotnej w Swidnicy Swidnica, | |
| Samodzielny Publiczny Zespół Zakładów Opieki Zdrowotnej w Ostrowi Mazowieckiej Ostrów Mazowiecka, | |
| San Diego Cardiac Center San Diego, California | |
| San Francisco V.A. Medical Center San Francisco, California | |
| San Francisco V.A. Medical Center San Francisco, California | |
| Sanatorio Finochietto Buenos Aires, | |
| Sanatorio Finochietto Buenos Aires, | |
| Sanatorio Güemes Ciudad de Buenos Aires, Buenos Aires | |
| Sanatorio Modelo Quilmes Quilmes, Buenos Aires | |
| Sanatorio Parque Rosario, Santa Fe Province | |
| Sanford Health - Fargo Fargo, North Dakota | |
| Sanford Health - Fargo Fargo, North Dakota | |
| Sanford Research Sioux Falls, South Dakota | |
| Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Sarawak Heart Centre Kota Samarahan, Sarawak | |
| Sardar Vallabhbhai Patel Institute of Medical Sciences and Research Ahmedabad, Gujarat | |
| Sentara Bayside Hospital Norfolk, Virginia | |
| Seoul National University Bundang Hospital Seongnam-si, Gyeonggi-do | |
| Seoul National University Hospital Seoul, Seoul Teugbyeolsi | |
| Servicios Integrales Nova de Monterrey San Nicolás de los Garza, | |
| Servicios Integrales Nova de Monterrey San Nicolás de los Garza, | |
| Seth GS Medical College & KEM Hospital Mumbai, Maharashtra | |
| Seth GS Medical College & KEM Hospital Mumbai, Maharashtra | |
| Severance Hospital, Yonsei University Health System Seoul, | |
| Shamir MC - Cardiology Department Beer Yaakov, | |
| Sheba MC - Cardiology Clinical Research Unit Tel Litwinsky, | |
| Shengjing Hospital of China Medical University Shenyang, | |
| Shengjing Hospital of China Medical University-Cardiology Shenyang, Liaoning | |
| Shiga University of Medical Science Hospital_Cardiology Shiga, | |
| Shri B. D. Mehta Mahavir Heart Institute Surat, Gujarat | |
| Shri Krishna Hrudayalaya & Critical Care Centre Nagpur, Maharashtra | |
| Shri Krishna Hrudayalaya & Critical Care Centre Nagpur, Maharashtra | |
| Shri Mahant Indiresh Hospital Dehradun, | |
| Sichuan Provincial People's Hospital-Cardiology Chengdu, Sichuan | |
| Sir Ganga Ram Hospital New Delhi, | |
| Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou, | |
| Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou, | |
| Sismanogleio General Hospital - Cardiology Department Marousi, | |
| Sourasky MC - Cardio Vascular Research Center Tel Aviv, | |
| South Oklahoma Heart Research, LLC Oklahoma City, Oklahoma | |
| South Oklahoma Heart Research, LLC Oklahoma City, Oklahoma | |
| Southlake Regional Hlth Centre Newmarket, Ontario | |
| Southlake Regional Hlth Centre Newmarket, Ontario | |
| Specialized Hospital For Active Cardiology Treatement Cardiolife OOD Varna, | |
| Specjalistyczny Szpital Im. E. Szczeklika W Tarnowie Tarnów, Lesser Poland Voivodeship | |
| Specjalistyczny Szpital Im. E. Szczeklika W Tarnowie Tarnów, Lesser Poland Voivodeship | |
| Specjalistyczny Szpital Miejski im. M.Kopernika w Toruniu Torun, | |
| Sri Jayadeva Institute of Cardiovascular Sciences & Research Bengaluru, Karnataka | |
| Sri Ramachandra Medical Centre Chennai, Tamil Nadu | |
| Sri Ramachandra Medical Centre Chennai, Tamil Nadu | |
| Ss. Annunziata Chieti, Abruzzo | |
| St Bartholomew's Hospital - Barts Heart Centre London, | |
| St Francis Hospital Lindner Research Center Roslyn, New York | |
| St Francis Hospital Lindner Research Center Roslyn, New York | |
| St. Boniface Hospital Winnipeg, Manitoba | |
| St. Boniface Hospital Winnipeg, Manitoba | |
| St. Luke's Idaho Cardiology Associates Meridian, Idaho | |
| St. Michael's Hospital Toronto, Ontario | |
| St. Michael's Hospital Toronto, Ontario | |
| St.Mary's Hospital_Cardiology Fukuoka, | |
| Sterling Hospitals, Race Course Road Vadodara, Gujarat | |
| Stony Brook University Hospital Stony Brook, New York | |
| Städt. Klinikum Dresden - 2. Medizinische Klinik Dresden, | |
| Sultan Ahmad Shah Medical Centre @IIUM Kuantan, Pahang | |
| Sunnybrook Health Sciences Centre Toronto, Ontario | |
| Sunnybrook Health Sciences Centre Toronto, Ontario | |
| Sunshine Coast University Hospital - Clinical Research Unit Birtinya, Queensland | |
| Sunshine Hospital - Western Centre for Health Research and Education St Albans, Victoria | |
| Svendborg Sygehus - Kardiologisk Svendborg, | |
| Swedish Medical Center_Seattle Seattle, Washington | |
| Szpital Grochowski im. dr med. Rafala Masztaka Sp. z o.o. Warsaw, | |
| Szpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o. Warsaw, | |
| Szpital Miejski Nr 4 w Gliwicach Sp. z o.o., Oddzial Kardiologii Gliwice, Silesian Voivodeship | |
| Szpital Uniwersytecki Nr 2 im. Dr. Jana Biziela Bydgoszcz, | |
| Szpital Wolski im. dr Anny Gostyńskiej Sp. z o.o. Warsaw, | |
| Szpitale Pomorskie Sp. z o.o. Gdynia, Pomeranian Voivodeship | |
| TEDA International Cardiovascular Hospital-Cardiovascular Tianjin, Tianjin Municipality | |
| Teda International Cardiovascular Hospital Tianjin, Tianjin Municipality | |
| Teikyo University Hospital_Cardiology Tokyo, | |
| Tennova HC Turkey Creek MC Knoxville, Tennessee | |
| Tergooi, Hilversum Hilversum, | |
| Texas Heart Inst Medical Ctr Houston, Texas | |
| The 1st Affiliated Hospital of WMU-Cardiology Wenzhou, Zhejiang | |
| The Alfred - Endocrinology & Diabetes Department South Yarra, Victoria | |
| The Catholic University of Korea, Bucheon St. Mary's Hospital Bucheon-si, Gyeonggi-do | |
| The Catholic University of Korea, Seoul St. Mary's Hospital Seoul, | |
| The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang | |
| The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang | |
| The First Affiliated Hospital of WMU-Cardiology Wenzhou, Zhejiang | |
| The First Affiliated Hospital of Xi'an Jiaotong University-Cardiovascular Xi'an, Shaanxi | |
| The First Affiliated hospital of Fujian Medical University Fuzhou, Fujian | |
| The First Affiliated hospital of Fujian Medical University Fuzhou, Fujian | |
| The Heart House Haddon Heights Haddon Heights, New Jersey | |
| The James Cook University Hospital - Cardiology Middlesbrough, | |
| The Madras Medical Mission Chennai, Tamil Nadu | |
| The New York Hospital Brooklyn, New York | |
| The People's Hospital of Guangxi Zhuang Autonomous Region Nanning, Guangxi | |
| The People's Hospital of Liaoning Province Shenyang, Liaoning | |
| The People's Hospital of Liaoning Province-Cardiology Shenyang, Liaoning | |
| The Prince Charles Hospital Chermside, Queensland | |
| The Prince Charles Hospital Chermside, Queensland | |
| The Sakakibara Heart Institute of Okayama_Department of Cardiovascular Medicine Okayama, | |
| The Sakakibara Heart Institute of Okayama_Department of Cardiovascular Medicine Okayama, | |
| The Second Affiliated Hospital Of Chongqing Medical University Chongqing, | |
| The Second Affiliated Hospital Of Chongqing Medical University Chongqing, | |
| The Second Affiliated Hospital of Nanjing Medical university Nanjing, | |
| The Second Affiliated Hospital of Nanjing Medical university Nanjing, | |
| The Second Xiangya Hospital of Central South University Changsha, | |
| The Second Xiangya Hospital of Central South University Changsha, | |
| Thoracic General Hospital Of Athens I Sotiria - Cardiology Department Athens, | |
| Tianjin People's Hospital Tianjin, Tianjin Municipality | |
| Tianjin People's Hospital Tianjin, Tianjin Municipality | |
| Toho University Sakura Medical Center_Cardiology Chiba, | |
| Tohoku University Hospital, Cardiovascular Sendai-shi, Miyagi, | |
| Tokai University Hospital_Cardiology Kanagawa, | |
| Tokai University Hospital_Cardiology Kanagawa, | |
| Tokat Gaziosmanpaşa Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji Tokat Province, | |
| Tokushima Prefectural Central Hospital_Cardiology Tokushima, | |
| Tokushima Prefectural Central Hospital_Cardiology Tokushima, | |
| Torbay Hospital - Cardiology Torquay, Devon | |
| Torrance Memorial Medical Center Torrance, California | |
| Townsville University Hospital Douglas, | |
| Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji Edirne, | |
| Trinity Health Michigan Heart Ypsilanti, Michigan | |
| Trinity Health Oakland Hospital Pontiac, Michigan | |
| Trinity Medical Group Minot, North Dakota | |
| Trinity Medical Group Minot, North Dakota | |
| Trinity Medical WNY, PC Buffalo, New York | |
| Tsuchiura Kyodo General Hospital_Internal Medicine Ibaraki, | |
| Tsuchiura Kyodo General Hospital_Internal Medicine Ibaraki, | |
| Tsukuba Medical Center Hospital_Department of Cardiology Tsukuba-shi, Ibaraki, | |
| U.G.H of Athens "Attikon" Chaidari, Athens, | |
| UCSD Medical Center San Diego, California | |
| UF Hlth Jacksonville Jacksonville, Florida | |
| UHN-Toronto General Hospital Toronto, Ontario | |
| UHN-Toronto General Hospital Toronto, Ontario | |
| UMAE Hospital IMSS Monterrey, Nuevo León | |
| UMC Groningen - Cardiologie Groningen, | |
| UMC of Southern Nevada Las Vegas, Nevada | |
| UMHAT "Sveta Marina" EAD Varna, | |
| UMHAT - Burgas AD Burgas, | |
| UMHAT Aleksandrovska EAD, Clinic of Cardiology Sofia, | |
| UMHAT Deva Maria EOOD Burgas, | |
| UMHAT Pulmed OOD - Plovdiv, Department of Cardiology Plovdiv, | |
| UMHAT Sofiamed EAD Sofia, | |
| UMHAT Sveta Anna Sofia AD, Clinic of Cardiology Sofia, | |
| UMHAT Sveta Ekaterina EAD Sofia, | |
| UMHAT Sveta Marina EAD, Second Clinic of Cardiology Varna, | |
| UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology Plovdiv, | |
| UMHATEM N.I. Pirogov EAD Sofia, | |
| UNC Hospital HVC_Meadowmont Chapel Hill, North Carolina | |
| UT Health University of Texas Houston, Texas | |
| Unidad Medica de Alta Especialidad No. 71 IMSS Torreón, Coahuila | |
| Unidad Medica de Alta Especialidad No. 71 IMSS Torreón, Coahuila | |
| Uniklinik Klinikum Bielefeld - Kardiologie und Internist. Intensivmedizin Bielefeld, | |
| Uniklinik Regensburg - Innere Medizin II Regensburg, | |
| Uniklinik TU Dresden - Herzzentrum Dresden GmbH Dresden, | |
| Uniklinik Tübingen - Innere Med. III Kardiologie und Angiologie Tübingen, | |
| UniklinikHeidelberg - Innere Med. III - Kardiologie, Angiologie, Pneumologie Heidelberg, | |
| Union Hospital Tongji Medical College Huazhong University of Science and Technology-Cardiology Wuhan, Hubei | |
| Univ Gen Hospital Larisa, Cardiology Medicine Clinic Larissa/Thessaly, | |
| Univ of Alberta Hosp Edmonton Edmonton, Alberta | |
| Univ of Mississippi Med Center Jackson, Mississippi | |
| Universiti Teknologi MARA, Sungai Buloh Campus Sungai Buloh, Selangor | |
| University General Hospital of Ioannina,Internal Medicine Ioannina, | |
| University General Hospital of Ioannina,Internal Medicine Ioannina, | |
| University Hospitals of Cleveland Medical Center Elyria, Ohio | |
| University Malaya Medical Centre Lembah Pantai, | |
| University Medical Center New Orleans New Orleans, Louisiana | |
| University Of Washington_Seattle Seattle, Washington | |
| University of CO - Division of Cardiology Aurora, Colorado | |
| University of Californ LA-UCLA Los Angeles, California | |
| University of California Irvine Orange, California | |
| University of Cincinnati/UC Health Cincinnati, Ohio | |
| University of Florida Gainesville, Florida | |
| University of Kansas Hospital Kansas City, Kansas | |
| University of Louisville Louisville, Kentucky | |
| University of Ottawa Heart Ins Ottawa, Ontario | |
| University of Rochester Rochester, New York | |
| University of Texas Medical Branch Galveston, Texas | |
| University of Texas Southwestern Medical Center Dallas, Texas | |
| University of Toledo Toledo, Ohio | |
| University of Virginia Charlottesville, Virginia | |
| Universitätsklinikum Düsseldorf - Klinik für Kardiologie, Pneumologie und Angiologie Düsseldorf, | |
| Universitätsklinikum Frankfurt aM - Kardiologie Frankfurt am Main, | |
| Universitätsklinikum Freiburg - Medical Center Freiburg im Breisgau, | |
| Universitätsklinikum Hamburg-Eppendorf - University Medical Center Hamburg-Eppendorf Hamburg, | |
| Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie Leipzig, | |
| Universitätsklinikum Mannheim - 1. Medizinische Klinik Mannheim, | |
| Uniwersytecki Szpital Kliniczny Nr 2 PUM W Szczecinie Szczecin, | |
| Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi Lodz, | |
| Uniwersytecki Szpital Kliniczny W Poznaniu Poznan, | |
| Uniwersytecki Szpital Kliniczny W Poznaniu Poznan, | |
| Uniwersytecki Szpital Kliniczny nr 2 Uniwersytetu Medycznego w Łodzi Lodz, | |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Bialystok, | |
| Uniwersytecki Szpital Kliniczny w Opolu Opole, | |
| Uniwersytecki Szpital Kliniczny w Opolu Opole, | |
| Uniwersyteckie Centrum Kliniczne (UCK) Gdansk, | |
| Uniwersyteckie Centrum Kliniczne (UCK) Gdansk, | |
| Uniwersyteckie Centrum Kliniczne WUM Warsaw, | |
| Uniwersyteckie Centrum Kliniczne WUM Warsaw, | |
| VA Medical Center_Minneapolis Minneapolis, Minnesota | |
| VA Medical Center_Salem Salem, Virginia | |
| VAGrtrLosAngelesHlthcareSystem Los Angeles, California | |
| Valley Clinical Trials Northridge, California | |
| Valley Clinical Trials Northridge, California | |
| Valley Health Link Winchester, Virginia | |
| Vancouver General Hospital Vancouver, | |
| Vanderbilt University Medical Center Nashville, Tennessee | |
| Vanderbilt University Medical Center Nashville, Tennessee | |
| Vardhaman Mahavir Medical College & Safdarjung Hospital New Delhi, National Capital Territory of Delhi | |
| Vijan Hospital & Research Centre Nashik, Maharashtra | |
| Virginia Commonwealth University Health System Richmond, Virginia | |
| Virtua Health Camden, New Jersey | |
| WMU Homer Stryker MD School of Medicine Kalamazoo, Michigan | |
| Wake Forest Uni Hlth Sciences High Point, North Carolina | |
| Washington University School of Medicine_St. Louis St Louis, Missouri | |
| Wayne State University/University Health Center Detroit, Michigan | |
| West China Hospital Sichuan University-Cardiology Chengdu, Sichuan | |
| West China Hospital Sichuan University-Cardiology Chengdu, Sichuan | |
| Westchester Medical Center Valhalla, New York | |
| Westchester Medical Center Valhalla, New York | |
| William Harvey Hospital Ashford, Kent | |
| William Harvey Hospital Ashford, Kent | |
| William Osler Hel Bra Civic Hs Brampton, Ontario | |
| William Osler Hel Bra Civic Hs Brampton, Ontario | |
| Winter Haven Hospital Winter Haven, Florida | |
| Winter Haven Hospital Winter Haven, Florida | |
| Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu Przemyśl, | |
| Wojewodzki Szpital Specjalistyczny W Bialej Podlaskiej Biała Podlaska, | |
| Wojewodzki Szpital Specjalistyczny We Wroclawiu Wroclaw, | |
| Wojewodzki Szpital Specjalistyczny We Wroclawiu Wroclaw, | |
| Wojewodzki Szpital Zespolony W Elblagu samodzielny publiczny zakład opieki zdrowotnej Elblag, | |
| Wojewodzki Szpital Zespolony W Elblagu samodzielny publiczny zakład opieki zdrowotnej Elblag, | |
| Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego, Lodz, | |
| Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego, Lodz, | |
| Wojewódzki Szpital Specjalistyczny im. NMP w Częstochowie Częstochowa, | |
| Wojewódzki Szpital Zespolony im. dr. Romana Ostrzyckiego w Koninie Konin, | |
| Wolfson MC - The Heart Institute Holon, | |
| Wonju Severance Christian Hospital Wŏnju, Kang-won-do | |
| Wright State University Fairborn, Ohio | |
| Xiangya Hospital Central-South University Changsha, Hunan | |
| Xiangya Hospital Central-South University Changsha, Hunan | |
| Yale Ctr for Clin Invest New Haven, Connecticut | |
| Yokohama City University Hospital Kanagawa, Yokohama, | |
| Yokohama City University Hospital Kanagawa, Yokohama, | |
| Yokohama City University Medical Center_Cardiovascular Center Kanagawa, | |
| Yokohama City University Medical Center_Cardiovascular Center Kanagawa, | |
| Yokohama Municipal Citizen's Hospital_Cardiology Kanagawa, | |
| Zespol Zakladow Opieki Zdrowotnej w Ostrowie Wielkopolskim Ostrów Wielkopolski, Greater Poland Voivodeship | |
| Zespół Zakładów Opieki Zdrowotnej w Ostrowie Wielkopolskim Ostrów Wielkopolski, Greater Poland Voivodeship | |
| Zhejiang Hospital, Zhejiang University School of Medicine Hangzhou, | |
| Zhejiang Hospital-Cardiology Hangzhou, Zhejiang | |
| Zhongda Hospital Southeast University Nanjing, | |
| Zhongda Hospital, Southeast University Nanjing, | |
| Zhongshan Hospital, Fudan University-Cardiology Shanghai, Shanghai Municipality | |
| İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Hastanesi- Prof. Dr. Murat Dilmener Yerleşkesi Istanbul, Bakirkoy | |
| İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü Istanbul, | |
| Śródmiejskie Centrum Kliniczne,II Oddział Kardiologii MSB, Klinika Chorób Serca CMKP Warsaw, |
HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants (ESTHI)
Nichol Nunn - nichol.nunn@hsc.utah.edu
NCT04177914
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Inclusion Criteria:
• Corrected age \<104 weeks and 0 days, AND
• Child is ≥ 37 weeks post menstrual age, AND
• Child must have symptomatic hydrocephalus, defined as: Ventriculomegaly on MRI (frontal-occipital horn ratio (FOR) \>0.45, which approximates "moderate ventriculomegaly"), and at least one of the following: * Head circumference \>98th percentile for corrected age with either bulging fontanelle or splayed sutures * Upgaze paresis/palsy (sundowning) * CSF leak * Papilledema * Tense pseudomeningocele or tense fluid along a track * Vomiting or irritability, with no other attributable cause * Bradycardias or apneas, with no other attributable cause * Intracranial pressure (ICP) monitoring showing persistent elevation of pressure with or without plateau waves AND
• No prior history of shunt insertion or endoscopic third ventriculostomy (ETV) procedure (previous temporization devices and/or external ventricular drains permissible)
Exclusion Criteria:
• Hydrocephalus due to intraventricular hemorrhage in a child born before 37 weeks gestational age; OR
• Anatomy not suitable for ETV+CPC or anteriorly placed ventriculoperitoneal shunt defined as: * Moderate to severe prepontine adhesions on steady state free precession (SSFP) or T2 weighted fast (turbo) spin echo (FSE/TSE) MRI, which includes the following sequences: FIESTA, FIESTA-C, TrueFISP, CISS, Balanced FFE (bFFE), CUBE, SPACE, VISTA, IsoFSE, and 3D MVOX * Closure of one or both foramina of Monro * Thick floor of third ventricle (≥ 3mm) * Narrow third ventricle (\<5mm) * Presence of scalp, bone, or ventricular lesions that make placement of an anterior shunt impracticable; OR
• Underlying condition with a high chance of mortality within 12 months; OR
• Hydrocephalus with loculated CSF compartments; OR
• Peritoneal cavity not suitable for distal shunt placement; OR
• Active CSF infection; OR
• Hydranencephaly; OR
• Child requires an intraventricular procedure (e.g. endoscopic biopsy) in addition to the initial first-time permanent procedure for the treatment of hydrocephalus.
PROCEDURE: Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization (ETV+CPC), DEVICE: Ventriculoperitoneal Shunt
Hydrocephalus
Hydrocephalus, Infants, Ventriculoperitoneal Shunt, ETV+CPC, endoscopic third ventriculostomy, choroid plexus cauterization
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Show 21 locations
Study Locations
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| Location | Contacts |
|---|---|
| Alberta Children's Hospital Calgary, Alberta | Ruksana Rashid, MBBS MPH MSc - (rsrashid@ucalgary.ca) |
| Arnold Palmer Hospital for Children Orlando, Florida | Richard Guerrero - (richard.guerrero@orlandohealth.com) |
| British Columbia Children's Hospital Vancouver, British Columbia | Annika Weirs - (annika.weir@cw.bc.ca) |
| Children's Hospital Colorado Aurora, Colorado | Susan Staulcup, 80045 - (SUSAN.STAULCUP@UCDENVER.EDU) |
| Children's Hospital of Los Angeles Glendale, California | Helen Berroya - (hberroya@chla.usc.edu) |
| Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania | Kimberly Diamond, BS, BA - (diamondkl@upmc.edu) |
| Children's Of Alabama Birmingham, Alabama | Anastasia Smith, MPH - (Anastasia.Smith@childrensal.org) |
| Johns Hopkins Children's Center Baltimore, Maryland | Sydney White - (swhit128@jh.edu) |
| Monroe Carell Jr. Children's Hospital at Vanderbilt Nashville, Tennessee | Julia Loes - (julia.loes@vumc.org) Stephen Gannon - (stephen.r.gannon@vumc.org) |
| Nationwide Children's Hospital Columbus, Ohio | Jared Haught - (Jared.Haught@nationwidechildrens.org) |
| Phoenix Children's Hospital Phoenix, Arizona | Bethany Norton - (bnorton1@phoenixchildrens.com) |
| Primary Children's Hospital Salt Lake City, Utah | Alli Ludwick - (allison.ludwick@hsc.utah.edu) |
| Seattle Children's Hospital Seattle, Washington | Jessica Becerra - (Jessica.Becerra@seattlechildrens.org) |
| St. Louis Children's Hospital St Louis, Missouri | Diego Morales, MS - (moralesd@wudosis.wustl.edu) Mary Goldschmidt - (goldschmidt@wustl.edu) |
| Texas Children's Hospital Houston, Texas | Edgardo Santisbon - (exsantis@texaschildrens.org) |
| The Hospital for Sick Children Toronto, Ontario | Homa Ashrafpour - (homa.ashrafpour@sickkids.ca) |
| The Pennsylvania State University University Park, Pennsylvania | |
| Trustees of Indiana University Indianapolis, Indiana | Mariah Shirrell - (mkillin@iu.edu) |
| Virginia Commonwealth University Henrico, Virginia | |
| Wolfson Children's Hospital Jacksonville, Florida | Asmaa Hatem - (Asmaa.Hatem@jax.ufl.edu) |
| Yale University New Haven, Connecticut |
ASSESS ALL ALS Study
ALL ALS Patient Navigator - info@all-als.org
NCT06578195
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Inclusion Criteria for ALS participants:
• Age 18 years or older
• Capable of providing informed consent
• Willing to follow study procedures
• Diagnosis of ALS by a physician
• Access to a smartphone, computer or tablet, and internet (need not be in the home - access to a public library or other available computer with internet connection is sufficient) Inclusion Criteria for control participants:
• Age 18 years or older
• Capable of providing informed consent
• Willing to follow study procedures
• No diagnosis of ALS , Progressive Muscular Atrophy (PMA) or Primary Lateral Sclerosis (PLS)
• No history of familial ALS/Frontotemporal Dementia (FTD) in a close family member\*\* unless the participant has previously tested negative for the known causative ALS genes. Participants with a family history of singleton ALS are permitted to enroll. * \*\* Defined by the presence of a known ALS causative gene such as C9orf72 in a family member or a family history suggestive of an inherited ALS/FTD syndrome defined by two family members with a history of ALS and/or FTD.
• Access to a smartphone, computer or tablet, and internet (need not be in the home - access to a public library or other available computer with internet connection is sufficient) Exclusion Criteria for all participants:
• Significant cognitive impairment, clinical dementia, or unstable psychiatric illness, including psychosis, active suicidal ideation, suicide attempt, or untreated major depression \<= 90 days of screening, that would interfere with the study procedure, according to Investigator's judgement.
• Clinically significant unstable medical condition (other than ALS) (e.g., cardiovascular instability, systemic infection, untreated thyroid dysfunction, malignant and potentially progressive cancer) that would render the participant unlikely to be able to complete 12 months of follow-up, according to Investigator's judgment. Exclusion Criteria for participants undergoing optional Lumbar Puncture
• Medically unable to undergo lumbar puncture (LP) as determined by the site investigator (i.e., bleeding disorder, a skin infection at or near the LP site, known or suspected intracranial or intraspinal tumor or other cause of increased intracranial pressure).
• Allergy to Lidocaine or other local anesthetic agents.
• Use of anticoagulant medication or antiplatelet medications (aside from aspirin 81 mg) that cannot be safely withheld prior to lumbar puncture.
• Blood dyscrasia, abnormal bleeding diathesis, or the use of dialysis for renal failure.
• Current pregnancy based on participant self-report
• Clinical judgement of the site investigator that the participant would be unable to undergo multiple lumbar punctures.
• Age 18 years or older
• Capable of providing informed consent
• Willing to follow study procedures
• Diagnosis of ALS by a physician
• Access to a smartphone, computer or tablet, and internet (need not be in the home - access to a public library or other available computer with internet connection is sufficient) Inclusion Criteria for control participants:
• Age 18 years or older
• Capable of providing informed consent
• Willing to follow study procedures
• No diagnosis of ALS , Progressive Muscular Atrophy (PMA) or Primary Lateral Sclerosis (PLS)
• No history of familial ALS/Frontotemporal Dementia (FTD) in a close family member\*\* unless the participant has previously tested negative for the known causative ALS genes. Participants with a family history of singleton ALS are permitted to enroll. * \*\* Defined by the presence of a known ALS causative gene such as C9orf72 in a family member or a family history suggestive of an inherited ALS/FTD syndrome defined by two family members with a history of ALS and/or FTD.
• Access to a smartphone, computer or tablet, and internet (need not be in the home - access to a public library or other available computer with internet connection is sufficient) Exclusion Criteria for all participants:
• Significant cognitive impairment, clinical dementia, or unstable psychiatric illness, including psychosis, active suicidal ideation, suicide attempt, or untreated major depression \<= 90 days of screening, that would interfere with the study procedure, according to Investigator's judgement.
• Clinically significant unstable medical condition (other than ALS) (e.g., cardiovascular instability, systemic infection, untreated thyroid dysfunction, malignant and potentially progressive cancer) that would render the participant unlikely to be able to complete 12 months of follow-up, according to Investigator's judgment. Exclusion Criteria for participants undergoing optional Lumbar Puncture
• Medically unable to undergo lumbar puncture (LP) as determined by the site investigator (i.e., bleeding disorder, a skin infection at or near the LP site, known or suspected intracranial or intraspinal tumor or other cause of increased intracranial pressure).
• Allergy to Lidocaine or other local anesthetic agents.
• Use of anticoagulant medication or antiplatelet medications (aside from aspirin 81 mg) that cannot be safely withheld prior to lumbar puncture.
• Blood dyscrasia, abnormal bleeding diathesis, or the use of dialysis for renal failure.
• Current pregnancy based on participant self-report
• Clinical judgement of the site investigator that the participant would be unable to undergo multiple lumbar punctures.
Amyotrophic Lateral Sclerosis
ALS, Amyotrophic Lateral Sclerosis, biomarker, observational
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Study Locations
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| Location | Contacts |
|---|---|
| Barrow Neurological Institute Phoenix, Arizona | Christopher Shiver - (fulton.research@dignityhealth.org) |
| CHALS-CCT, University of Puerto Rico, Medical Sciences Campus San Juan, Puerto Rico | Frances M Aponte - (frances.aponte2@upr.edu) |
| Columbia University New York, New York | Ben Hoover - (alsresearch@cumc.columbia.edu) |
| Dartmouth Hitchcock Medical Center Lebanon, New Hampshire | Gina Kersey - (neuroresearch@hitchcock.org) |
| Duke University Durham, North Carolina | Duke Research Team - (alsresearch@dm.duke.edu) |
| Georgetown University Washington D.C., District of Columbia | Cassandra Holmes - (cassie.holmes@georgetown.edu) |
| Henry Ford Health West Bloomfield, Michigan | Maria Stotland - (mstotla1@hfhs.org) |
| Hospital for Special Care New Britain, Connecticut | Sabine Lebel-Hardenac - (shardenack@hfsc.org) |
| Indiana University Indianapolis, Indiana | Lisa Grinstead - (lgrinste@iu.edu) Patti Hogan - (hoganpr@iu.edu) |
| John Hopkins University Baltimore, Maryland | Delayne Willie - (dwillie2@jh.edu) |
| Massachusetts General Brigham Boston, Massachusetts | Miranda Duncan - (mghassessallals@mgb.org) |
| Mayo Clinic Rochester, Minnesota | Jany Dagher - (dagher.jany@mayo.edu) Jeffery Gainer - (gainer.jeffery@mayo.edu) |
| Nih/Ninds Bethesda, Maryland | Katelyn Porter - (katelyn.porter@nih.gov) |
| Northwestern University Chicago, Illinois | Aeryn Hopwood - (aeryn.hopwood@northwestern.edu) |
| Ohio State University Columbus, Ohio | Alexander Michael - (alsresearch@osumc.edu) |
| Penn State Health Hershey, Pennsylvania | Michele Hare - (nervemuscle@pennstatehealth.psu.edu) |
| Providence ALS Center Portland, Oregon | Kimberly Perry - (kimberly.perry2@providence.org) |
| Saint Alphonsus Regional Medical Center Boise, Idaho | Helena Snider - (neuro.research@saintalphonsus.org) |
| Temple University Philadelphia, Pennsylvania | John Furey - (tuf40109@temple.edu) |
| Texas Neurology Dallas, Texas | Haley Rucker - (hrucker@texasneurology.com) Reham Azab - (razab@texasneurology.com) |
| University of Alabama Birmingham Birmingham, Alabama | Melanie Benge - (melaniebenge@uabmc.edu) |
| University of California San Diego La Jolla, California | Gil Gutierrez - (grg005@health.ucsd.edu) |
| University of California, Irvine Orange, California | Rosa Gonzalez - (rosaig1@hs.uci.edu) |
| University of California, San Francisco San Francisco, California | Hannah George - (hannah.george@ucsf.edu) |
| University of Colorado Anschutz Medical Campus Aurora, Colorado | Alexis Shepardson - (neuroresearch@cuanschutz.edu) |
| University of Michigan Ann Arbor, Michigan | Caroline Piecuch - (carolinp@med.umich.edu) |
| University of Minnesota Minneapolis, Minnesota | Julia Munoz - (munoz156@umn.edu) |
| University of Nebraska Medical Center Omaha, Nebraska | Nathan McKain - (nmckain@unmc.edu) |
| University of Utah Salt Lake City, Utah | Scott Redlin - (scott.redlin@utah.edu) |
| University of Washington Seattle, Washington | Lila Brisk - (lbrisk@uw.edu) |
| Virginia Commonwealth University Henrico, Virginia | Demetrius Carter - (demetrius.r.carter@vcuhealth.org) |
| Washington University St Louis, Missouri | Jesse Markway - (als@wustl.edu) |
A Phase 2 Study of ACR-368 in Endometrial Adenocarcinoma
Mansoor Raza Mirza, MD - ACR-368-201ClinicalTrial@acrivon.com
NCT05548296
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Inclusion Criteria:
General
• Participant must be able to give signed, written informed consent.
• Participant must have histologically documented, high-grade endometrial cancer. Arms 1 and 2
• All high-grade epithelial endometrial histological subtypes are eligible including: endometrioid (all Grade 3), serous, carcinosarcomas, clear-cell carcinoma, and mixed histologies. Note: Subjects with p53 mutant Grade 2 endometrioid cancer are eligible Arms 3 and 4
• Serous carcinoma or mixed tumors with a majority component of serous carcinoma or carcinosarcoma where the carcinomatous component is serous carcinoma.
• Treatment History Requirements: Arms 1 and 2
• Subject must have received prior platinum-based chemotherapy
• Subject must have received prior anti-PD-(L)1 therapy
• Subject must not have received more than three lines of prior systemic therapy Arms 3 and 4
• Subject must have received prior platinum-based chemotherapy
• Subject must have received prior anti-PD-(L)1 therapy
• Subject must not have received more than two lines of prior systemic therapy
• Participant must have histologically confirmed metastatic cancer that has progressed during or after at least 1 prior therapeutic regimen.
• Participant must have at least 1 measurable lesion per RECIST v1.1 criteria (by local Investigator) in a baseline tumor imaging that has been obtained within 28 days of the treatment start. Participant must have radiographic evidence of disease progression based on RECIST v1.1 criteria following the most recent line of treatment.
• Arm 1 and 2 only: Participant must be willing to provide tissue from a newly obtained tumor biopsy from an accessible tumor lesion not previously irradiated after written informed consent. Newly obtained is defined as a specimen taken after written informed consent is obtained, during the 28-day Screening period. Note: Subjects at EU sites are not eligible for Arm 1 and Arm 2
• For all subjects participating in Arm 3 and 4, archival tumor tissue must be provided either during or after screening either as a tissue block or at least 20 unstained slides.
• Participant must have stabilized or recovered (Grade 1 or baseline) from all prior therapy related toxicities, except as follows:
• Alopecia is accepted.
• Endocrine events from prior immunotherapy stabilized at ≤ Grade 2 due to need for replacement therapy are accepted (including hypothyroidism, diabetes mellitus, or adrenal insufficiency).
• Neuropathy events from prior cytotoxic therapies stabilized at ≤ Grade 2 are accepted.
• Participant must have an Eastern Cooperative Oncology Group Performance Status 0 or 1.
• Participant must have an estimated life expectancy of longer than 3 months in the clinical judgment of the investigator.
• Participant must have adequate organ function at Screening, defined as:
• Absolute neutrophil count \> 1500 cells/µL without growth factor support within 1 week prior to obtaining the hematology values at Screening.
• Hemoglobin ≥ 9.0 g/dL.
• Platelets ≥ 150,000 cells/µL without transfusion within 1 week prior to obtaining the hematology values at Screening.
• Renal function is defined as Glomerular filtration rate (GFR) ≥ 50 mL/min/1.73m2. Note: GFR may be estimated using site standard methods (e.g., CKD-EPI, MDRD, or Cockcroft-Gault) or measured using 24-hour urine collection or Chrome-EDTA clearance, as per site standard practice.
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 × upper limit of normal (ULN); ≤ 5 × ULN if liver metastases are present.
• Total bilirubin ≤ 1.5 × ULN not associated with Gilbert's syndrome. If associated with Gilbert's syndrome ≤ 3 x ULN is acceptable.
• Serum albumin ≥ 3 g/dL.
• Participant must have adequate coagulation profile as defined below if not on anticoagulation. If subject is receiving anticoagulation therapy, then subject must be on a stable dose of anticoagulation for ≥ 1 month:
• Prothrombin time within 1.5 x ULN.
• Activated partial thromboplastin time within 1.5 x ULN.
Exclusion Criteria:
General
• Participant with known symptomatic brain metastases requiring \> 10 mg/day of prednisolone (or its equivalent). Participants with previously diagnosed brain metastases are eligible if they have completed their treatment, have recovered from the acute effects of radiation therapy or surgery prior to the start of ACR-368 treatment, fulfill the steroid requirement for these metastases, and are neurologically stable based on central nervous system imaging ≥ 4 weeks after treatment.
• Participant has mesenchymal tumors of the uterus.
• Participant has a history of clinically meaningful ascites, defined as history of paracentesis or thoracentesis with therapeutic intent, within 4 weeks of Screening. Subjects with planned therapeutic paracentesis or thoracentesis between Screening and Cycle 1 Day 1 dosing are excluded.
• Participant had systemic therapy or radiation therapy within 3 weeks prior to the first dose of study drug.
• Participants has known human immunodeficiency virus (HIV), hepatitis B, or hepatitis C infection that is considered uncontrolled based on the criteria included in Appendix 2.
• Participant has a history of clinically meaningful coagulopathy, bleeding diathesis.
• Participant has cardiovascular disease, defined as:
• Uncontrolled hypertension defined as blood pressure \> 160/90 mmHg at Screening confirmed by repeat (medication permitted).
• History of torsades de pointes, significant Screening electrocardiogram (ECG) abnormalities, including ventricular rhythm disturbances, unstable cardiac arrhythmia requiring medication, pathologic symptomatic bradycardia, left bundle branch block, second degree atrioventricular (AV) block type II, third degree AV block, Grade ≥ 2 bradycardia, uncorrected hypokalemia not amenable to correction, congenital long QT syndrome, prolonged QT interval due to medications, corrected QT based on Fridericia's formula (QTcF) \> 450 msec (for men) or \> 470 msec (for women).
• Symptomatic heart failure (per New York Heart Association guidelines; (Caraballo, 2019), unstable angina, myocardial infarction, severe cardiovascular disease (ejection fraction \< 20%, transient ischemic attack, or cerebrovascular accident within 6 months of Day 1).
• Participant has a history of major surgery within 4 weeks of Screening.
• Participant has experienced bowel obstruction related to the current cancer within the last 4 weeks or signs or symptoms of intestinal obstruction, which include nausea, vomiting, or objective radiologic finding of bowel obstruction in the last 4 weeks before the start of the treatment.
• Participant has taken a prior cell cycle CHK1 inhibitor, including ACR-368
DRUG: ACR-368, DRUG: Gemcitabine, DIAGNOSTIC_TEST: OncoSignature
Endometrial Adenocarcinoma
Endometrial Cancer, Endometrial Neoplasm, Ultralow dose gemcitabine, ACR-368
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Show 90 locations
Study Locations
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| Location | Contacts |
|---|---|
| Alaska Women's Cancer Center Anchorage, Alaska | |
| American Oncology Partners of Maryland Pa Bethesda, Maryland | |
| Arizona Oncology Associate, PC- HOPE Tucson, Arizona | |
| Ascension St. Vicent Hospital, Inc. Indianapolis, Indiana | |
| CRO Aviano Aviano, | |
| Carle Cancer Center Urbana, Illinois | |
| Cedars Sinai Medical Center Los Angeles, California | |
| Centre Francois Baclesse Caen, | |
| Centre Leon Berard Lyon Cedex08, | |
| City of Hope National Medical Center Duarte, California | |
| Cleveland Clinic Foundation Cleveland, Ohio | |
| Dana Farber Cancer Institute Boston, Massachusetts | |
| Emory University Atlanta, Georgia | |
| Firsthealth of The Carolinas Pinehurst, North Carolina | |
| Florida Gynecologic Oncology/Regional Cancer Center Fort Myers, Florida | |
| Fondazione Pascale Istituto Tumori Naples, | |
| Fox Chase Cancer Center Philadelphia, Pennsylvania | |
| Fred Hutchinson Cancer Center Seattle, Washington | |
| Froedtert and Medical College of Wisconsin Milwaukee, Wisconsin | |
| Fundación Instituto Valenciano de Oncologia (IVO) Valencia, | |
| Gabrail Cancer Center Canton, Ohio | |
| HCA Midwest Kansas City, Missouri | |
| Hoag Cancer Center Newport Beach, California | |
| Holy Cross Hospital Silver Spring, Maryland | |
| HonorHealth Scottsdale, Arizona | |
| Hospital Clinic de Barcelona Barcelona, | |
| Hospital Universitario 12 de Octubre Madrid, | |
| Hospital Universitario La Paz Madrid, | |
| Hospital Universitario Ramon y Cajal Madrid, | |
| Humanitas University Pieve Emanuele, | |
| Huntsman Cancer Institute, University of Utah Salt Lake City, Utah | |
| Insitute de Cancérologie de l'Ouest Saint-Herblain, | |
| Institut Català of Oncology (ICO) Barcelona, | |
| Institute Gustave Roussy Villejuif, | |
| Istituto Clinico Cannizzaro Catania Catania, | |
| Istituto Europeo Di Oncologia Milan, | |
| John Theurer Cancer Center at Hackensack University Medical Center Hackensack, New Jersey | |
| KEM | Evang. Kliniken Essen-Mitte Essen, | |
| Karmanos Cancer Institute Detroit, Michigan | |
| LSU Health Sciences New Orleans, Louisiana | |
| Laura & Isaac Perlmutter Cancer Center New York, New York | |
| Memorial Sloan-Kettering Cancer Center New York, New York | |
| Miami Valley Hospital South Centerville, Ohio | |
| Mount Sinai Comprehensive Cancer Center Miami Beach, Florida | |
| Mount Sinai Health System New York, New York | |
| National Institutes of Health, Clinical Center Bethesda, Maryland | |
| New York Presbyterian Hospital-Columbia University Medical Center New York, New York | |
| Northeast Georgia Medical Center Gainesville, Georgia | |
| Northwest Cancer Specialists, P.C. Vancouver, Washington | |
| Northwestern Medicine Chicago, Illinois | |
| Ohio State University Columbus, Ohio | |
| Oncology Associates of Oregon Eugene, Oregon | |
| Oregon Health & Sciences University Portland, Oregon | |
| Ospedale Mauriziano Torino Turin, | |
| Policlinico Gemelli Roma, | |
| Providence Sacred Heart Medical Center and Children's Hospital Spokane, Washington | |
| Rutgers Cancer Institute of Nj New Brunswick, New Jersey | |
| Sanford Health Sioux Falls, South Dakota | |
| Stanford Cancer Center Palo Alto, California | |
| Stephenson Cancer Center at OU Health Oklahoma City, Oklahoma | Ashley Willy - (phase1-referrals@ouhsc.edu) |
| Summit Cancer Center Spokane, Washington | |
| Swedish Cancer Center Seattle, Washington | |
| Texas Oncology Fort Worth, Texas | |
| Texas Oncology-Dallas Presbyterian Hospital Dallas, Texas | |
| Trials365, LLC Shreveport, Louisiana | |
| UC Irvine Health Orange, California | |
| UC San Diego Moores Cancer Center La Jolla, California | |
| USC/Norris Comprehensive Cancer Center Los Angeles, California | |
| University of Arkansas for Medical Sciences Little Rock, Arkansas | |
| University of California Los Angeles (UCLA) Santa Monica, California | |
| University of California, Davis Comprehensive Cancer Center Sacramento, California | |
| University of Chicago Medicine Chicago, Illinois | |
| University of Cincinnati Cancer Center Cincinnati, Ohio | |
| University of Colorado Aurora, Colorado | |
| University of Illinois Cancer Center Chicago, Illinois | |
| University of Iowa Iowa City, Iowa | |
| University of Massachusetts Chan Medical School Worcester, Massachusetts | |
| University of North Carolina at Chapel Hill Chapel Hill, North Carolina | |
| University of Rochester Medical Center Rochester, New York | |
| University of South Alabama Mitchell Cancer Institute Mobile, Alabama | |
| University of Texas Southwestern Medical Center Dallas, Texas | |
| University of Texas, MD Anderson Cancer Center Houston, Texas | |
| University of Virginia Health System Charlottesville, Virginia | |
| Universitätsklinikum Münster, Klinik für Frauenheilkunde und Geburtshilfe Münster, | |
| Universitätsklinikum Ulm, Frauenheilunde und Geburtshilfe Ulm, | |
| Vall d'Hebron Institute of Oncology (VHIO) Barcelona, | |
| Virginia Commonwealth University Henrico, Virginia | |
| West Penn Hospital Pittsburgh, Pennsylvania | |
| Women & Infants Hospital Providence, Rhode Island | - (oncologyresearch@wihri.org) |
| Yale Cancer Center New Haven, Connecticut |
DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers
Boehringer Ingelheim - clintriage.rdg@boehringer-ingelheim.com
NCT05882058
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Inclusion criteria:
• Male or female participants ≥18 years old and at least at the legal age of consent in countries where it is greater than 18 years at the time of signature of the informed consent form (ICF).
• Signed and dated written informed consent in accordance with International Council for Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial.
• Part 1: Histologically or cytologically confirmed, cancer of the following histologies: * Small cell lung cancer (SCLC) * Extra-pulmonary neuroendocrine carcinoma (epNEC) (except Merkel cell carcinoma (MCC), Medullary thyroid cancer (MTC) and Neuroendocrine prostate cancer (NEPC)) * Large cell neuroendocrine carcinoma (LCNEC) of the lung Patients with tumours with mixed histologies for any above type are eligible only if the neuroendocrine carcinoma/small tumour cells component is predominant and represents at least 50% of the overall tumour tissue. Patients must have progressed or recurred after standard of care therapy * SCLC: after at least two prior lines of therapy, including at least one platinum-based regimen; in countries where standard of care in first line therapy includes PD-L1 inhibitor treatment patients should have received the combination of platinum-based regimen plus PD-L1 inhibitor unless they have been unable to receive checkpoint inhibitor treatment. * Therapy includes PD-L1 inhibitor treatment; patients should have received the combination of platinum-based regimen plus PD-L1 inhibitor unless they have been unable to receive checkpoint inhibitor treatment. * epNEC/LCNEC: after at least one platinum-based regimen. Part 2 and part 3: Histologically or cytologically confirmed epNEC (except MCC, MTC and NEPC) with centrally assessed DLL3 high expression status. Patients must have progressed or recurred after at least one platinum-based regimen.
• Eastern Cooperative Oncology Group (ECOG) score of 0 or 1.,
• Measurable lesions as defined per Response Evaluation Criteria In Solid Tumours (RECIST) v 1.1 within 21 days prior to the first dose of BI 764532.
• Part 1: Availability of archival tumour tissue sample Part 2 and part 3: Availability of archival formalin-fixed paraffin-embedded (FFPE) tumour tissue sample. Following specimens are not allowed: Fine Needle Aspiration (FNA), Cytology samples, decalcified bone samples.
• Adequate organ function as defined in the protocol.
• All toxicities related to previous anti-cancer therapies have resolved = Common Terminology Criteria for Adverse Events (CTCAE) Grade 1 prior to trial treatment administration (except for alopecia, peripheral neuropathy, fatigue and endocrinopathies controlled by replacement therapy which must be = CTCAE Grade 2 and amenorrhea/menstrual disorders which can be any grade).
• Women of childbearing potential (WOCBP) and men able to father a child must be ready and able to use acceptable methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria and instructions on the duration of their use is provided in the participant information
• Only for Part 3, at the timepoint of Screening 02: * For Cycle 1, patients should be willing to stay within 1 hour driving distance for 48 hours after IMP administration and confirm availability of a caregiver for the same timeframe. * Patients should be considered suitable by the investigator to follow instructions applicable to the reduced monitoring cohort, such as taking their temperature and administration of oral medication at home if needed. Exclusion criteria:
• Untreated or symptomatic brain metastases. (Part 2 and part 3: identified during the mandatory assessment by brain MRI within 21 days before first trial drug administration.) Participants with treated, stable brain metastases are eligible provided they meet the following criteria: * Radiotherapy or surgery for brain metastases was completed at least 2 weeks prior to the first administration of BI 764532. * Patient is off steroids for at least 7 days (physiologic doses of steroids are permitted), and the patient is off anti-epileptic drugs for at least 7 days or on stable doses of anti-epileptic drugs for malignant central nervous system (CNS) disease.
• Presence of leptomeningeal disease or, part 2 and part 3: epidural disease including spinal cord compression.
• Part 1: Active/previous history of interstitial lung disease or non-infectious pneumonitis (any grade). Part 2 and part 3: Active/previous history of interstitial lung disease, pulmonary fibrosis, organizing pneumonia or non-infectious pneumonitis (any grade). Patients with a history of therapy-related pneumonitis that is considered clinically resolved are eligible.
• Participants who experienced severe, life-threatening immune-mediated adverse events or infusion-related reactions including those that lead to permanent discontinuation while on treatment with immuno-oncology agents.
• Prior anti-cancer therapy: * Patients who have been treated with any other anti-cancer drug within 4 weeks or within 5 half-life periods (whichever is shorter) prior to first administration of BI 764532. * Patients who have been treated with extensive field radiotherapy including whole brain irradiation within 2 weeks prior to first administration of BI 764532.
• Previous treatment with Delta-like ligand 3 (DLL3)-targeting T cell engagers or cell therapies.
• Diagnosis of immunodeficiency or systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of BI 764532. Physiological replacement of steroids is allowed.
• Unresolved toxicity from prior anti-tumour therapy, defined in the inclusion criteria. Further exclusion criteria apply.
• Male or female participants ≥18 years old and at least at the legal age of consent in countries where it is greater than 18 years at the time of signature of the informed consent form (ICF).
• Signed and dated written informed consent in accordance with International Council for Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial.
• Part 1: Histologically or cytologically confirmed, cancer of the following histologies: * Small cell lung cancer (SCLC) * Extra-pulmonary neuroendocrine carcinoma (epNEC) (except Merkel cell carcinoma (MCC), Medullary thyroid cancer (MTC) and Neuroendocrine prostate cancer (NEPC)) * Large cell neuroendocrine carcinoma (LCNEC) of the lung Patients with tumours with mixed histologies for any above type are eligible only if the neuroendocrine carcinoma/small tumour cells component is predominant and represents at least 50% of the overall tumour tissue. Patients must have progressed or recurred after standard of care therapy * SCLC: after at least two prior lines of therapy, including at least one platinum-based regimen; in countries where standard of care in first line therapy includes PD-L1 inhibitor treatment patients should have received the combination of platinum-based regimen plus PD-L1 inhibitor unless they have been unable to receive checkpoint inhibitor treatment. * Therapy includes PD-L1 inhibitor treatment; patients should have received the combination of platinum-based regimen plus PD-L1 inhibitor unless they have been unable to receive checkpoint inhibitor treatment. * epNEC/LCNEC: after at least one platinum-based regimen. Part 2 and part 3: Histologically or cytologically confirmed epNEC (except MCC, MTC and NEPC) with centrally assessed DLL3 high expression status. Patients must have progressed or recurred after at least one platinum-based regimen.
• Eastern Cooperative Oncology Group (ECOG) score of 0 or 1.,
• Measurable lesions as defined per Response Evaluation Criteria In Solid Tumours (RECIST) v 1.1 within 21 days prior to the first dose of BI 764532.
• Part 1: Availability of archival tumour tissue sample Part 2 and part 3: Availability of archival formalin-fixed paraffin-embedded (FFPE) tumour tissue sample. Following specimens are not allowed: Fine Needle Aspiration (FNA), Cytology samples, decalcified bone samples.
• Adequate organ function as defined in the protocol.
• All toxicities related to previous anti-cancer therapies have resolved = Common Terminology Criteria for Adverse Events (CTCAE) Grade 1 prior to trial treatment administration (except for alopecia, peripheral neuropathy, fatigue and endocrinopathies controlled by replacement therapy which must be = CTCAE Grade 2 and amenorrhea/menstrual disorders which can be any grade).
• Women of childbearing potential (WOCBP) and men able to father a child must be ready and able to use acceptable methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria and instructions on the duration of their use is provided in the participant information
• Only for Part 3, at the timepoint of Screening 02: * For Cycle 1, patients should be willing to stay within 1 hour driving distance for 48 hours after IMP administration and confirm availability of a caregiver for the same timeframe. * Patients should be considered suitable by the investigator to follow instructions applicable to the reduced monitoring cohort, such as taking their temperature and administration of oral medication at home if needed. Exclusion criteria:
• Untreated or symptomatic brain metastases. (Part 2 and part 3: identified during the mandatory assessment by brain MRI within 21 days before first trial drug administration.) Participants with treated, stable brain metastases are eligible provided they meet the following criteria: * Radiotherapy or surgery for brain metastases was completed at least 2 weeks prior to the first administration of BI 764532. * Patient is off steroids for at least 7 days (physiologic doses of steroids are permitted), and the patient is off anti-epileptic drugs for at least 7 days or on stable doses of anti-epileptic drugs for malignant central nervous system (CNS) disease.
• Presence of leptomeningeal disease or, part 2 and part 3: epidural disease including spinal cord compression.
• Part 1: Active/previous history of interstitial lung disease or non-infectious pneumonitis (any grade). Part 2 and part 3: Active/previous history of interstitial lung disease, pulmonary fibrosis, organizing pneumonia or non-infectious pneumonitis (any grade). Patients with a history of therapy-related pneumonitis that is considered clinically resolved are eligible.
• Participants who experienced severe, life-threatening immune-mediated adverse events or infusion-related reactions including those that lead to permanent discontinuation while on treatment with immuno-oncology agents.
• Prior anti-cancer therapy: * Patients who have been treated with any other anti-cancer drug within 4 weeks or within 5 half-life periods (whichever is shorter) prior to first administration of BI 764532. * Patients who have been treated with extensive field radiotherapy including whole brain irradiation within 2 weeks prior to first administration of BI 764532.
• Previous treatment with Delta-like ligand 3 (DLL3)-targeting T cell engagers or cell therapies.
• Diagnosis of immunodeficiency or systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of BI 764532. Physiological replacement of steroids is allowed.
• Unresolved toxicity from prior anti-tumour therapy, defined in the inclusion criteria. Further exclusion criteria apply.
DRUG: BI 764532, dose 1, DRUG: BI 764532, dose 2
Small Cell Lung Carcinoma, Neuroendocrine Neoplasms, Extra-pulmonary Neuroendocrine Carcinoma
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Show 59 locations
Study Locations
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| Location | Contacts |
|---|---|
| 960 Hospital of the Chinese People's Liberation Army Jinan, | Boehringer Ingelheim - (china@bitrialsupport.com) |
| Aichi Cancer Center Hospital Nagoya, | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| Asan Medical Center Seoul, | |
| Asklepios Fachkliniken München-Gauting Gauting, | |
| Chang Gung Memorial Hospital, Linkou Taoyuan City, | |
| Dana-Farber Cancer Institute Boston, Massachusetts | |
| Evangelische Lungenklinik Berlin Berlin, | |
| Freeman Hospital Newcastle upon Tyne, | Boehringer Ingelheim - (unitedkingdom@bitrialsupport.com) |
| H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| HOP Civil Strasbourg, | |
| HOP Intercommunal Créteil, | |
| Hopital Cochin Paris, | |
| Hospital CUF Descobertas-Lisboa-69316 Lisbon, | Boehringer Ingelheim - (portugal@bitrialsupport.com) |
| Hospital Clinico Universitario de Valencia Valencia, | |
| Hospital Cuf porto Porto, | |
| Hospital Del Mar Barcelona, | |
| Hospital Universitari Vall d'Hebron Barcelona, | Boehringer Ingelheim - (espana@bitrialsupport.com) |
| Hospital Universitario 12 de Octubre Madrid, | Boehringer Ingelheim - (espana@bitrialsupport.com) |
| Hospital Universitario Virgen de la Victoria Málaga, | Boehringer Ingelheim - (espana@bitrialsupport.com) |
| Indiana University Indianapolis, Indiana | |
| Infirmary Cancer Care Mobile, Alabama | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Japanese Foundation for Cancer Research Kōtō City, | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| Kindai University Hospital Sakai, Osaka | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| Laura & Isaac Perlmutter Cancer Center at NYU Langone Health New York, New York | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Leicester Royal Infirmary Leicester, | Boehringer Ingelheim - (unitedkingdom@bitrialsupport.com) |
| LungenClinic Grosshansdorf GmbH Großhansdorf, | |
| MHAT Heart and Brain Pleven, | |
| Mayo Clinic Cancer Center Rochester, Minnesota | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Mayo Clinic, Rochester Rochester, Minnesota | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Mayo Clinic-Arizona Phoenix, Arizona | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Montefiore Medical Center The Bronx, New York | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Multiprofile Hospital For Active Treatment-Uni Hospital Ltd. Panagyurishte, | |
| NCKUH Tainan, | |
| National Cancer Center Hospital Tokyo, | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| National Cancer Center Hospital East Kashiwa, | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| Osaka International Cancer Institute Osaka, | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| Qilu Hospital, Shangdong University Jinan, | Boehringer Ingelheim - (china@bitrialsupport.com) |
| Samsung Medical Center Seoul, | |
| Sendai Kousei Hospital Miyagi, | |
| Severance Hospital Seoul, | Boehringer Ingelheim - (namhan@bitrialsupport.com) |
| Shanghai Chest Hospital Shanghai, | Boehringer Ingelheim - (china@bitrialsupport.com) |
| Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine Hangzhou, | Boehringer Ingelheim - (china@bitrialsupport.com) |
| Taipei Veterans General Hospital Taipei, | |
| The Christie Hospital Manchester, Lancashire | Boehringer Ingelheim - (unitedkingdom@bitrialsupport.com) |
| The Second Affiliated Hospital to Nanchang University Nanchang, | Boehringer Ingelheim - (china@bitrialsupport.com) |
| UZ Leuven Leuven, | Boehringer Ingelheim - (belgique@bitrialsupport.com) |
| Universitair Ziekenhuis Gent Ghent, Oost-Vlaanderen | Boehringer Ingelheim - (belgique@bitrialsupport.com) |
| University College Hospital London, | Boehringer Ingelheim - (unitedkingdom@bitrialsupport.com) |
| University of California San Francisco San Francisco, California | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| University of Kansas Cancer Center Kansas City, Kansas | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| University of Kentucky Medical Center Lexington, Kentucky | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| University of Maryland School of Medicine Baltimore, Maryland | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| University of Miami Miami, Florida | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Universitätsklinikum Carl Gustav Carus Dresden Dresden, Saxony | Boehringer Ingelheim - (deutschland@bitrialsupport.com) |
| Universitätsklinikum Erlangen Erlangen, | Boehringer Ingelheim - (deutschland@bitrialsupport.com) |
| Universitätsmedizin der Johannes Gutenberg-Universität Mainz Mainz, | Boehringer Ingelheim - (deutschland@bitrialsupport.com) |
| Valkyrie Clinical Trials Los Angeles, California | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Virginia Commonwealth University Health- Adult Outpatient Pavilion Richmond, Virginia | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| West China Hospital, Sichuan University Chengdu, | Boehringer Ingelheim - (china@bitrialsupport.com) |
ALS/MND Natural History Study Data Repository
Natalia Tarasenko - ntarasenko@mgh.harvard.edu
NCT05966038
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Inclusion Criteria:
* A clinical diagnosis of El Escorial of suspected, possible, probable, or definite ALS or
* Other motor neuron disorders, including but not limited to Spinal-Bulbar Muscular Atrophy (SBMA, Kennedy's disease), Spinal Muscular Atrophy (SMA), Primary Lateral Sclerosis (PLS), Progressive Muscular Atrophy (PMA), and Progressive Bulbar Palsy (PBP)
Exclusion Criteria:
* Disease does not meet criteria for any motor neuron disorder ALS, PLS, MND (Motor Neurone DIsease), Kennedy Disease, PMA - Progressive Muscular Atrophy, PBP - Progressive Bulbar Palsy
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Show 18 locations
Study Locations
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| Location | Contacts |
|---|---|
| Centro Clinico NEMO Milano Milan, | Monica Montuori - (monica.montuori@centrocliniconemo.it) |
| Hadassah Medical Organization Jerusalem, | Michal Zabari - (michalza@hadassah.org.il) |
| Henry Ford Health System Detroit, Michigan | Anne Vallis - (avallis1@hfhs.org) |
| Istituti Clinici Scientifici Maugeri SpA Milan, | Camilla Garrè - (camilla.garre@icsmaugeri.it) |
| Kaiser Permanente Fresno, California | Chris Greer - (chris.x.lindgren@kp.org) |
| Lahey Clinic Burlington, Massachusetts | Sorieba Fofanah - (Sorieba.Fofanah@lahey.org) Melo Catia - (catia.s.melo@lahey.org) |
| Loma Linda University Health Loma Linda, California | |
| Northwestern University Chicago, Illinois | Emma Schmidt - (emma.schmidt@northwestern.edu) |
| Providence ALS Clinic Portland, Oregon | Tyler Regan - (tyler.regan@providence.org) |
| Saint Louis University St Louis, Missouri | Katie Forsman - (katie.forsman@health.slu.edu) |
| Tel Aviv Medical Center Tel Aviv, | Beatrice Abramovich - (beatricen@tlvmc.gov.il) |
| Temple University Lewis Katz School of Medicine Philadelphia, Pennsylvania | John Furey - (john.furey0001@temple.edu) |
| Thomas Jefferson University Philadelphia, Pennsylvania | Gemma Krautzel - (Gemma.Krautzel@jefferson.edu) |
| Trinity Health Michigan Grand Rapids, Michigan | Nicolina Evola - (nicolina.evola@trinity-health.org) Katherine Schwass - (Katherine.Schwass@trinity-health.org) |
| University of Florida Gainesville, Florida | Jennifer Steshyn - (Jennifer.Steshyn@neurology.ufl.edu) |
| University of Minnesota Minneapolis, Minnesota | Valerie Ferment - (ferm0016@umn.edu) |
| University of Pittsburgh Pittsburgh, Pennsylvania | Helen Ismail - (ismailhh@upmc.edu) |
| Virginia Commonwealth University Henrico, Virginia | Demetrius Carter - (Demetrius.R.Carter@vcuhealth.org) |
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
ctrrecruit@vcu.edu
NCT06500455
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Inclusion Criteria:
* Pathologically (histologically or cytologically) proven diagnosis of one of the following solid tumor malignancies within 5 years prior to registration:
* Non-small cell lung cancer
* Melanoma
* Breast cancer
* Renal cell carcinoma
* Gastrointestinal cancer
* If the original histologic proof of malignancy is greater than 5 years, then more recent pathologic confirmation (e.g., from a systemic site or brain metastasis) or unequivocal imaging confirmation of extracranial metastatic disease (e.g. CT of the chest/abdomen/pelvis, positron emission tomography \[PET\]/CT, etc.) is required
* Patients must have at least 1 and up to 8 total intact brain metastases detected on a contrast-enhanced MRI performed ≤ 21 days prior to registration
* At least 1 of the up to 8 lesions must be a study eligible lesion, defined as lesion with a maximum diameter as measured on any orthogonal plane (axial, sagittal, coronal) of ≥ 1.0 cm and ≤ 3.0 cm
* All brain metastases must be located outside of the brainstem and ≥ 5 mm from the optic nerves or optic chiasm and ≤ 3.0 cm in maximum dimension
* Note: brainstem metastases per the MRI within 21 days of registration are an exclusion criterion; however, if the MRI used for treatment planning performed within 7 days of SRS/FSRS reveals a brainstem metastasis, the patient remains eligible if the patient is considered an appropriate radiosurgery candidate per the local investigator
* Patients must have a diagnosis-specific graded prognostic assessment ≥ 1.5
* No more than 2 lesions planned for resection if clinically indicated
* No known leptomeningeal disease (LMD)
* Note: For the purposes of exclusion, LMD is a clinical diagnosis, defined as positive cerebrospinal fluid (CSF) cytology and/or unequivocal radiologic or clinical evidence of leptomeningeal involvement. Patients with leptomeningeal symptoms in the setting of leptomeningeal enhancement by imaging (MRI) would be considered to have LMD even in the absence of positive CSF cytology. In contrast, an asymptomatic or minimally symptomatic patient with mild or nonspecific leptomeningeal enhancement (MRI) would not be considered to have LMD. In that patient, CSF sampling is not required to formally exclude LMD, but can be performed at the investigator's discretion based on level of clinical suspicion
* Age ≥ 18 years
* Karnofsky performance status (KPS) ≥ 60
* Negative urine or serum pregnancy test (in persons of childbearing potential) within 14 days prior to registration. Childbearing potential is defined as any person who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal
* No prior radiotherapy to the brain (partial or whole brain irradiation, SRS, FSRS, or prophylactic cranial irradiation \[PCI\])
* New York Heart Association Functional Classification II or better (NYHA Functional Classification III/IV are not eligible) (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification)
* No active infection currently requiring intravenous (IV) antibiotic management
* No hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
* No chronic obstructive pulmonary disease exacerbation or other acute respiratory illness precluding study therapy PROCEDURE: Computed Tomography, RADIATION: Fractionated Stereotactic Radiation Therapy, PROCEDURE: Magnetic Resonance Imaging, RADIATION: Stereotactic Radiosurgery
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Digestive System Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Metastatic Renal Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
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Show 263 locations
Study Locations
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| Location | Contacts |
|---|---|
| Aspirus Cancer Care - James Beck Cancer Center Rhinelander, Wisconsin | Site Public Contact - (Beth.Knetter@aspirus.org) |
| Aspirus Cancer Care - Stevens Point Stevens Point, Wisconsin | Site Public Contact - (Beth.Knetter@aspirus.org) |
| Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids, Wisconsin | |
| Aspirus Regional Cancer Center Wausau, Wisconsin | |
| Banner University Medical Center - Tucson Tucson, Arizona | |
| Baptist Health Hardin Elizabethtown, Kentucky | |
| Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston, Texas | Site Public Contact - (burton@bcm.edu) |
| Beacon Hospital Petaling Jaya, Selangor | |
| Boca Raton Regional Hospital Boca Raton, Florida | |
| Cancer Care Center of O'Fallon O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Care Specialists of Illinois - Decatur Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Care and Hematology-Fort Collins Fort Collins, Colorado | Site Public Contact - (Roster@nrgoncology.org) |
| Carle Cancer Center Urbana, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Effingham Effingham, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | Site Public Contact - (Research@carle.com) |
| Carle at The Riverfront Danville, Illinois | Site Public Contact - (Research@Carle.com) |
| Case Western Reserve University Cleveland, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| Castle Medical Center Kailua, Hawaii | |
| Cedars Sinai Medical Center Los Angeles, California | |
| Central Maryland Radiation Oncology in Howard County Columbia, Maryland | |
| Centralia Oncology Clinic Centralia, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Chambersburg Hospital Chambersburg, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| City of Hope Antelope Valley Lancaster, California | Site Public Contact - (becomingapatient@coh.org) |
| City of Hope Comprehensive Cancer Center Duarte, California | Site Public Contact - (becomingapatient@coh.org) |
| City of Hope Corona Corona, California | Site Public Contact - (becomingapatient@coh.org) |
| City of Hope South Bay Torrance, California | |
| City of Hope South Pasadena South Pasadena, California | Site Public Contact - (becomingapatient@coh.org) |
| City of Hope Upland Upland, California | Site Public Contact - (becomingapatient@coh.org) |
| City of Hope at Irvine Lennar Irvine, California | |
| Clackamas Radiation Oncology Center Clackamas, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Coborn Cancer Center at Saint Cloud Hospital Saint Cloud, Minnesota | Site Public Contact - (coborncancercenter@centracare.com) |
| Community Medical Center Missoula, Montana | Site Public Contact - (Lennette.Gonzales@rwjbh.org) |
| Cork Radiation Oncology Associates Limited Cork, | |
| Cork University Hospital Cork, | |
| Crossroads Cancer Center Effingham, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Decatur Memorial Hospital Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Delaware Health Center-Grady Cancer Center Delaware, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Edward Hospital/Cancer Center Naperville, Illinois | |
| Elmhurst Memorial Hospital Elmhurst, Illinois | Site Public Contact - (Jrohde@emhc.org) |
| Emory Saint Joseph's Hospital Atlanta, Georgia | |
| Emory University Hospital Midtown Atlanta, Georgia | |
| Emory University Hospital/Winship Cancer Institute Atlanta, Georgia | |
| Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Goshen Center for Cancer Care Goshen, Indiana | Site Public Contact - (cccois@goshenhealth.com) |
| Grady Memorial Hospital Delaware, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Grant Medical Center Columbus, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Gundersen Lutheran Medical Center La Crosse, Wisconsin | Site Public Contact - (cancerctr@gundersenhealth.org) |
| HSHS Saint Elizabeth's Hospital O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Hartford Hospital Hartford, Connecticut | |
| Hawaii Cancer Care - Westridge ‘Aiea, Hawaii | Site Public Contact - (info@hawaiicancercare.com) |
| Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii | Site Public Contact - (i.webster@hawaiicancercare.com) |
| Hennepin County Medical Center Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Henry Ford Cancer Institute-Downriver Brownstown, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Hospital Detroit, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford West Bloomfield Hospital West Bloomfield, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Huntsman Cancer Institute/University of Utah Salt Lake City, Utah | Site Public Contact - (cancerinfo@hci.utah.edu) |
| Indu and Raj Soin Medical Center Beavercreek, Ohio | |
| Jefferson Cherry Hill Hospital Cherry Hill, New Jersey | Site Public Contact - (ONCTrialNow@jefferson.edu) |
| Jefferson Torresdale Hospital Philadelphia, Pennsylvania | Site Public Contact - (ONCTrialNow@jefferson.edu) |
| Jersey Shore Medical Center Neptune City, New Jersey | |
| John Muir Medical Center-Walnut Creek Walnut Creek, California | Site Public Contact - (clinicalresearch@johnmuirhealth.com) |
| Kaiser Permanente Los Angeles Medical Center Los Angeles, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Anaheim Anaheim, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Bellflower Bellflower, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Ontario Ontario, California | Site Public Contact - (clinical.trials@kp.org) |
| Kapiolani Medical Center for Women and Children Honolulu, Hawaii | |
| Kettering Medical Center Kettering, Ohio | |
| Langlade Hospital and Cancer Center Antigo, Wisconsin | Site Public Contact - (Juli.Alford@aspirus.org) |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York | Site Public Contact - (CancerTrials@nyulangone.org) |
| Legacy Cancer Institute Medical Oncology and Day Treatment Vancouver, Washington | Site Public Contact - (oncologyresearch@lhs.org) |
| Legacy Good Samaritan Hospital and Medical Center Portland, Oregon | Site Public Contact - (cancer@lhs.org) |
| Legacy Meridian Park Hospital Tualatin, Oregon | |
| Legacy Mount Hood Medical Center Gresham, Oregon | |
| Legacy Salmon Creek Hospital Vancouver, Washington | |
| Lenox Hill Hospital New York, New York | |
| Loyola University Medical Center Maywood, Illinois | |
| M D Anderson Cancer Center Houston, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson League City League City, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson West Houston Houston, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson in Sugar Land Sugar Land, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson in The Woodlands Conroe, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MU Health - University Hospital/Ellis Fischel Cancer Center Columbia, Missouri | |
| MaineHealth Cancer Care Center of York County Sanford, Maine | |
| MaineHealth Maine Medical Center - Portland Portland, Maine | Site Public Contact - (clinicalresearch@mainehealth.org) |
| MaineHealth Maine Medical Center- Scarborough Scarborough, Maine | Site Public Contact - (clinicalresearch@mainehealth.org) |
| Manhattan Eye Ear and Throat Hospital New York, New York | |
| Mary Greeley Medical Center Ames, Iowa | |
| Maryland Proton Treatment Center Baltimore, Maryland | Site Public Contact - (info@mdproton.com) |
| McFarland Clinic - Ames Ames, Iowa | Site Public Contact - (ksoder@mcfarlandclinic.com) |
| Medical Center of the Rockies Loveland, Colorado | |
| Medical College of Wisconsin Milwaukee, Wisconsin | |
| Memorial Hermann Texas Medical Center Houston, Texas | |
| Memorial Hospital East Shiloh, Illinois | Site Public Contact - (dschwab@wustl.edu) |
| Memorial Hospital North Colorado Springs, Colorado | |
| Memorial Sloan Kettering Basking Ridge Basking Ridge, New Jersey | |
| Memorial Sloan Kettering Bergen Montvale, New Jersey | |
| Memorial Sloan Kettering Cancer Center New York, New York | |
| Memorial Sloan Kettering Commack Commack, New York | |
| Memorial Sloan Kettering Monmouth Middletown, New Jersey | |
| Memorial Sloan Kettering Nassau Uniondale, New York | |
| Memorial Sloan Kettering Westchester Harrison, New York | |
| Mercy Hospital Springfield Springfield, Missouri | |
| Miami Cancer Institute Miami, Florida | |
| Moffitt Cancer Center Tampa, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Moffitt Cancer Center - McKinley Campus Tampa, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Moffitt Cancer Center at Wesley Chapel Wesley Chapel, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Moffitt Cancer Center-International Plaza Tampa, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Montefiore Medical Center - Moses Campus The Bronx, New York | Site Public Contact - (eskwak@montefiore.org) |
| Montefiore Medical Center-Einstein Campus The Bronx, New York | Site Public Contact - (eskwak@montefiore.org) |
| Montefiore Medical Center-Weiler Hospital The Bronx, New York | Site Public Contact - (eskwak@montefiore.org) |
| Monticello Cancer Center Monticello, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mount Sinai Chelsea New York, New York | Site Public Contact - (CCTO@mssm.edu) |
| Mount Sinai Hospital New York, New York | Site Public Contact - (CCTO@mssm.edu) |
| Mount Sinai West New York, New York | Site Public Contact - (CCTO@mssm.edu) |
| MyMichigan Medical Center Saginaw Saginaw, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| MyMichigan Medical Center Tawas Tawas City, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| NRG Oncology Philadelphia, Pennsylvania | Rupesh R. Kotecha - (rupeshk@baptisthealth.net) |
| NYP/Weill Cornell Medical Center New York, New York | |
| NYU Langone Hospital - Brooklyn Brooklyn, New York | Site Public Contact - (david.wallach@nyulangone.org) |
| NYU Langone Hospital - Long Island Mineola, New York | Site Public Contact - (cancertrials@nyulangone.org) |
| Nebraska Medicine-Bellevue Bellevue, Nebraska | Site Public Contact - (unmcrsa@unmc.edu) |
| Nebraska Medicine-Village Pointe Omaha, Nebraska | |
| New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn, New York | Site Public Contact - (Adg9003@nyp.org) |
| Newark Beth Israel Medical Center Newark, New Jersey | Site Public Contact - (Christine.Kosmides@rwjbh.org) |
| Northeast Radiation Oncology Center Dunmore, Pennsylvania | |
| Northwell Health/Center for Advanced Medicine Lake Success, New York | |
| Northwest Cancer Center - Hobart Hobart, Indiana | |
| Northwest Cancer Center - Main Campus Crown Point, Indiana | |
| Northwest Cancer Center - Valparaiso Valparaiso, Indiana | Site Public Contact - (CancerResearch@COMHS.org) |
| Northwest Oncology LLC Dyer, Indiana | |
| Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Orland Park Orland Park, Illinois | Site Public Contact - (nctnprogram_rhlccc@northwestern.edu) |
| Northwestern University Chicago, Illinois | Site Public Contact - (cancer@northwestern.edu) |
| Norton Brownsboro Hospital and Medical Campus Louisville, Kentucky | Site Public Contact - (Roster@nrgoncology.org) |
| Ohio State University Comprehensive Cancer Center Columbus, Ohio | Site Public Contact - (Jamesline@osumc.edu) |
| Owensboro Health Mitchell Memorial Cancer Center Owensboro, Kentucky | Site Public Contact - (vanissa.sorrels@owensborohealth.org) |
| Pamela Youde Nethersole Eastern Hospital Chai Wan, | |
| Parkland Health Center - Farmington Farmington, Missouri | |
| Penn State Milton S Hershey Medical Center Hershey, Pennsylvania | Site Public Contact - (CTO@hmc.psu.edu) |
| Piedmont Hospital Atlanta, Georgia | Site Public Contact - (ORS@piedmont.org) |
| Poudre Valley Hospital Fort Collins, Colorado | |
| Providence Medical Foundation - Santa Rosa Santa Rosa, California | |
| Providence Portland Medical Center Portland, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Providence Queen of The Valley Napa, California | |
| Providence Saint Vincent Medical Center Portland, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Queen's Cancer Cenrer - POB I Honolulu, Hawaii | |
| Queen's Cancer Center - Kuakini Honolulu, Hawaii | |
| Queen's Medical Center Honolulu, Hawaii | |
| Reading Hospital West Reading, Pennsylvania | |
| Renown Regional Medical Center Reno, Nevada | Site Public Contact - (research@sncrf.org) |
| Ridgeview Medical Center Waconia, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Riverside Methodist Hospital Columbus, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Robert Wood Johnson University Hospital Somerset Somerville, New Jersey | Site Public Contact - (Siby.Varughese@rwjbh.org) |
| Rush MD Anderson Cancer Center Chicago, Illinois | Site Public Contact - (Cancer_Studies@rush.edu) |
| Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey | |
| Rutgers New Jersey Medical School Newark, New Jersey | |
| SUNY Upstate Medical Center-Community Campus Syracuse, New York | |
| Saint Barnabas Medical Center Livingston, New Jersey | Site Public Contact - (joanne.loeb@rwjbh.org) |
| Saint Elizabeth Youngstown Hospital Youngstown, Ohio | |
| Saint Francis Cancer Center Greenville, South Carolina | Site Public Contact - (Heather_Rich@bshsi.org) |
| Saint Francis Hospital Greenville, South Carolina | Site Public Contact - (Heather_Rich@bshsi.org) |
| Saint Luke's Cancer Center - Allentown Allentown, Pennsylvania | |
| Saint Luke's Hospital - Monroe Campus Stroudsburg, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| Saint Luke's Hospital - Upper Bucks Campus Quakertown, Pennsylvania | |
| Saint Luke's Hospital-Anderson Campus Easton, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| Saint Luke's University Hospital-Bethlehem Campus Bethlehem, Pennsylvania | |
| Saint Lukes Hospital Dublin, Co Dublin | |
| Saint Mary Medical Center Hobart, Indiana | Site Public Contact - (CancerResearch@COMHS.org) |
| Sanford Broadway Medical Center Fargo, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota | Site Public Contact - (OncologyClinicTrialsSF@sanfordhealth.org) |
| Sanford Roger Maris Cancer Center Fargo, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota | Site Public Contact - (OncologyClinicalTrialsSF@SanfordHealth.org) |
| Sidney Kimmel Cancer Center Washington Township Sewell, New Jersey | Site Public Contact - (ONCTrialNow@jefferson.edu) |
| Sinai Hospital of Baltimore Baltimore, Maryland | |
| Siteman Cancer Center at Christian Hospital St Louis, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Siteman Cancer Center at Saint Peters Hospital City of Saint Peters, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Siteman Cancer Center at West County Hospital Creve Coeur, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Siteman Cancer Center-South County St Louis, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Southern Illinois University School of Medicine Springfield, Illinois | |
| Springfield Clinic Springfield, Illinois | |
| Springfield Memorial Hospital Springfield, Illinois | Site Public Contact - (pallante.beth@mhsil.com) |
| Stanford Cancer Institute Palo Alto Palo Alto, California | Site Public Contact - (ccto-office@stanford.edu) |
| State University of New York Upstate Medical University Syracuse, New York | |
| Stony Brook University Medical Center Stony Brook, New York | |
| The Community Hospital Munster, Indiana | |
| The Hospital of Central Connecticut New Britain, Connecticut | |
| The James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky | |
| The New York Hospital Medical Center of Queens Flushing, New York | Site Public Contact - (Roster@nrgoncology.org) |
| The Queen's Medical Center - West Oahu ‘Ewa Beach, Hawaii | Site Public Contact - (rohta@queens.org) |
| The Research Institute of the McGill University Health Centre (MUHC) Montreal, Quebec | Site Public Contact - (evelyn.ortega@muhc.mcgill.ca) |
| The University of Kansas Cancer Center - Olathe Olathe, Kansas | Site Public Contact - (OlatheCCResearch@kumc.edu) |
| The Valley Hospital - Luckow Pavilion Paramus, New Jersey | Site Public Contact - (clinicaltrialsresearch@valleyhealth.com) |
| ThedaCare Regional Cancer Center Appleton, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| Thomas Jefferson University Hospital Philadelphia, Pennsylvania | Site Public Contact - (ONCTrialNow@jefferson.edu) |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| UC Comprehensive Cancer Center at Silver Cross New Lenox, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California | Site Public Contact - (ucstudy@uci.edu) |
| UC San Diego Health System - Encinitas Encinitas, California | |
| UC San Diego Medical Center - Hillcrest San Diego, California | Site Public Contact - (rhabbaba@health.ucsd.edu) |
| UC San Diego Moores Cancer Center La Jolla, California | Site Public Contact - (cancercto@ucsd.edu) |
| UCHealth Greeley Hospital Greeley, Colorado | Site Public Contact - (Roster@nrgoncology.org) |
| UCHealth Memorial Hospital Central Colorado Springs, Colorado | |
| UCHealth University of Colorado Hospital Aurora, Colorado | |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine, California | Site Public Contact - (ucstudy@uci.edu) |
| UChicago Medicine Northwest Indiana Crown Point, Indiana | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| UH Seidman Cancer Center at Lake Health Mentor Campus Mentor, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| UH Seidman Cancer Center at UH Avon Health Center Avon, Ohio | |
| UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie, Maryland | |
| UM Capital Region Medical Center Largo, Maryland | Site Public Contact - (Sarah.Larson@umm.edu) |
| UM Sylvester Comprehensive Cancer Center at Aventura Aventura, Florida | |
| UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables, Florida | |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach, Florida | |
| UM Sylvester Comprehensive Cancer Center at Doral Doral, Florida | Site Public Contact - (kginnity@med.miami.edu) |
| UM Sylvester Comprehensive Cancer Center at Kendall Miami, Florida | |
| UM Sylvester Comprehensive Cancer Center at Plantation Plantation, Florida | |
| UM Upper Chesapeake Medical Center Bel Air, Maryland | |
| UPMC-Presbyterian Hospital Pittsburgh, Pennsylvania | |
| UPMC-Shadyside Hospital Pittsburgh, Pennsylvania | |
| University College Hospital Galway Galway, Co Galway | Site Public Contact - (info@cancercontrol.ie) |
| University of Arizona Cancer Center-North Campus Tucson, Arizona | |
| University of Arkansas for Medical Sciences Little Rock, Arkansas | |
| University of Chicago Comprehensive Cancer Center Chicago, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| University of Chicago Medicine-Orland Park Orland Park, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| University of Cincinnati Cancer Center-UC Medical Center Cincinnati, Ohio | Site Public Contact - (cancer@uchealth.com) |
| University of Cincinnati Cancer Center-West Chester West Chester, Ohio | Site Public Contact - (cancer@uchealth.com) |
| University of Hawaii Cancer Center Honolulu, Hawaii | |
| University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa | |
| University of Kansas Cancer Center Kansas City, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center-Overland Park Overland Park, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kentucky/Markey Cancer Center Lexington, Kentucky | |
| University of Maryland Shore Medical Center at Easton Easton, Maryland | Site Public Contact - (Christina.weisenborn@umm.edu) |
| University of Maryland/Greenebaum Cancer Center Baltimore, Maryland | |
| University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida | |
| University of Michigan Rogel Cancer Center Ann Arbor, Michigan | Site Public Contact - (CancerAnswerLine@med.umich.edu) |
| University of Minnesota/Masonic Cancer Center Minneapolis, Minnesota | |
| University of Nebraska Medical Center Omaha, Nebraska | Site Public Contact - (unmcrsa@unmc.edu) |
| University of New Mexico Cancer Center Albuquerque, New Mexico | Site Public Contact - (HSC-ClinicalTrialInfo@salud.unm.edu) |
| University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma | Site Public Contact - (ou-clinical-trials@ouhsc.edu) |
| University of Pennsylvania/Abramson Cancer Center Philadelphia, Pennsylvania | Site Public Contact - (PMCancerResearch@pennmedicine.upenn.edu) |
| University of Rochester Rochester, New York | |
| University of Texas Health Science Center at San Antonio San Antonio, Texas | Site Public Contact - (phoresearchoffice@uthscsa.edu) |
| University of Vermont Medical Center Burlington, Vermont | Site Public Contact - (rpo@uvm.edu) |
| University of Vermont and State Agricultural College Burlington, Vermont | Site Public Contact - (rpo@uvm.edu) |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison, Wisconsin | Site Public Contact - (clinicaltrials@cancer.wisc.edu) |
| University of Wisconsin Carbone Cancer Center - University Hospital Madison, Wisconsin | Site Public Contact - (clinicaltrials@cancer.wisc.edu) |
| UofL Health Medical Center Northeast Louisville, Kentucky | Site Public Contact - (ctoinfo@louisville.edu) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| Valley Health System Ridgewood Campus Ridgewood, New Jersey | Site Public Contact - (clinicaltrialsresearch@valleyhealth.com) |
| Valley Medical Center Renton, Washington | Site Public Contact - (research@valleymed.org) |
| Vanderbilt Breast Center at One Hundred Oaks Nashville, Tennessee | |
| Vanderbilt University/Ingram Cancer Center Nashville, Tennessee | |
| Washington University School of Medicine St Louis, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| WellSpan Health-York Cancer Center York, Pennsylvania | |
| WellSpan Health-York Hospital York, Pennsylvania | |
| WellStar Cobb Hospital Austell, Georgia | Site Public Contact - (research@wellstar.org) |
| Wellstar Kennestone Hospital Marietta, Georgia | Site Public Contact - (research@wellstar.org) |
| Wilcox Memorial Hospital and Kauai Medical Clinic Lihue, Hawaii | |
| William E Kahlert Regional Cancer Center/Sinai Hospital Westminster, Maryland | |
| Women's Diagnostic Center - Munster Munster, Indiana | Site Public Contact - (mnicholson@comhs.org) |
Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas (RELIEF)
Samira Shojaee, MD, MPH - samira.shojaee@vumc.org
NCT06427538
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Inclusion Criteria:
* Patients with complicated parapneumonic pleural effusion and empyema requiring chest tube placement as standard of care for inpatient management of their pleural space infection with or without intrapleural tissue plasminogen activator and deoxyribonuclease therapy
* Age \> 18 years old.
Exclusion Criteria:
* Patients who have surgical tubes that can't accommodate a three-way stopcock.
* Study subject has any disease or condition that interferes with the safe completion of the study.
* Inability to provide informed consent.
* Inability to undergo a chest X-ray.
* If the managing clinician believes the chest tube will be placed for less than 24 hours.
* Patients with an indwelling pleural catheter (IPC) OTHER: Saline Flush
Empyema, Pleural, Pleural Infection
empyema, pleural infection, chest tube, saline flush
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Study Locations
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| Location | Contacts |
|---|---|
| Creighton University Omaha, Nebraska | Zachary S DePew, MD - (zachary.depew@commonspirit.org) |
| Henry Ford Detroit, Michigan | Labib Debiane, MD - (ldebian1@hfhs.org) |
| Mount Sinai New York, New York | Udit S Chaddha - (udit.chaddha@mssm.edu) |
| Vanderbilt University Medical Center Nashville, Tennessee | |
| Virginia Commonwealth University Henrico, Virginia | Danai Khemasuwan - (Danai.Khemasuwan@vcuhealth.org) |
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
ctrrecruit@vcu.edu
NCT05946213
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Inclusion Criteria:
* Pathologically (histologically or cytologically) proven diagnosis of adenocarcinoma of prostate cancer
* High-risk disease defined as having at least one or more of the following:
* cT3a-T3b by digital exam or imaging (American Joint Committee on Cancer \[AJCC\] 8th edition \[Ed.\]) Note: cT4 by imaging or on digital rectal exam is not allowed
* The patient's prostate specific antigen (PSA) value \> 20 ng/mL prior to starting androgen deprivation therapy (ADT) Note: Patients taking a 5-alpha reductase inhibitor (ex finasteride or dutasteride) are eligible The baseline PSA value should be doubled for PSAs taken while on 5-alpha reductase inhibitors
* Gleason Score of 8-10
* Pelvic node positive by conventional imaging with a short axis of at least 1.0 cm
* Prostate gland volume less than 100 cc prior to initiation of ADT as reported at time of biopsy or by separate measure with ultrasound or other imaging modalities including MRI or CT scan
* No definitive clinical or radiologic evidence of metastatic disease outside of the pelvic nodes (M1a, M1b or M1c) on conventional imaging (i.e. bone scan, CT scan, MRI); Negative prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is an acceptable substitute
* Age \>= 18
* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-2
* No prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
* No prior radical prostatectomy
* No prior ablative or focal therapy to the prostate (including, but not limited to, transrectal or transurethral high-intensity focused ultrasound \[HIFU\], laser ablation, cryotherapy, irreversible electroporation \[IRE\], and vascular-targeted photodynamic therapy)
* Prior pharmacologic androgen ablation for prostate cancer is allowed only if the onset of androgen ablation (both luteinizing hormone releasing hormone \[LHRH\] agonist and oral anti-androgen) is =\< 185 days prior to registration; Please note: PSA prior to the start of any ADT will be used to define disease
* No contraindication to prostate MRI (required for planning of radiotherapy in both arms)
* Patients enrolled in NRG-GU009 must be enrolled in NRG-GU013 prior to radiation therapy treatment planning and start of radiation therapy PROCEDURE: Biospecimen Collection, PROCEDURE: Bone Scan, PROCEDURE: Computed Tomography, RADIATION: External Beam Radiation Therapy, PROCEDURE: Magnetic Resonance Imaging, PROCEDURE: Positron Emission Tomography, OTHER: Quality-of-Life Assessment, OTHER: Questionnaire Administration, RADIATION: Stereotactic Body Radiation Therapy
Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
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| Location | Contacts |
|---|---|
| AMG Crystal Lake - Oncology Crystal Lake, Illinois | Site Public Contact - (advocateresearch@advocate.com) |
| AMG Libertyville - Oncology Libertyville, Illinois | Site Public Contact - (advocateresearch@advocatehealth.com) |
| Adams Cancer Center Gettysburg, Pennsylvania | |
| Advocate Christ Medical Center Oak Lawn, Illinois | |
| Advocate Good Samaritan Hospital Downers Grove, Illinois | Site Public Contact - (Barbara.barhamand@advocatehealth.com) |
| Advocate Good Shepherd Hospital Barrington, Illinois | |
| Advocate High Tech Medical Park Palos Heights, Illinois | Site Public Contact - (ncorp@aah.org) |
| Advocate Illinois Masonic Medical Center Chicago, Illinois | |
| Advocate Lutheran General Hospital Park Ridge, Illinois | |
| Advocate Outpatient Center - Aurora Aurora, Illinois | Site Public Contact - (ncorp@aah.org) |
| Advocate Sherman Hospital Elgin, Illinois | |
| Advocate South Suburban Hospital Hazel Crest, Illinois | |
| Alton Memorial Hospital Alton, Illinois | |
| Altru Cancer Center Grand Forks, North Dakota | |
| American Fork Hospital / Huntsman Intermountain Cancer Center American Fork, Utah | Site Public Contact - (officeofresearch@imail.org) |
| Ascension Via Christi Hospitals Wichita Wichita, Kansas | Site Public Contact - (research@viachristi.org) |
| Aspirus Cancer Care - James Beck Cancer Center Rhinelander, Wisconsin | Site Public Contact - (Beth.Knetter@aspirus.org) |
| Aspirus Cancer Care - Stevens Point Stevens Point, Wisconsin | Site Public Contact - (Beth.Knetter@aspirus.org) |
| Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids, Wisconsin | |
| Aspirus Regional Cancer Center Wausau, Wisconsin | |
| Atlantic Health Sciences Corporation-Saint John Regional Hospital Saint John, New Brunswick | |
| Augusta Health Center for Cancer and Blood Disorders Fishersville, Virginia | |
| Aultman Health Foundation Canton, Ohio | Site Public Contact - (ClinicalReserachDept@aultman.com) |
| Aurora Bay Area Medical Group-Marinette Marinette, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora BayCare Medical Center Green Bay, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora Cancer Care-Grafton Grafton, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora Cancer Care-Kenosha South Kenosha, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora Cancer Care-Milwaukee Milwaukee, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora Cancer Care-Racine Racine, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora Cancer Care-Southern Lakes VLCC Burlington, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora Health Care Germantown Health Center Germantown, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora Medical Center in Summit Summit, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora Saint Luke's Medical Center Milwaukee, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora Sinai Medical Center Milwaukee, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Aurora West Allis Medical Center West Allis, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Baptist Health Hardin Elizabethtown, Kentucky | |
| Bay Pines VA Healthcare System Bay Pines, Florida | Site Public Contact - (vhabayresearch@va.gov) |
| Benefis Sletten Cancer Institute Great Falls, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Billings Clinic Cancer Center Billings, Montana | Site Public Contact - (research@billingsclinic.org) |
| Bon Secours Cancer Institute at Reynolds Crossing Richmond, Virginia | Site Public Contact - (Anne_caramella@bshsi.org) |
| Bon Secours Memorial Regional Medical Center Mechanicsville, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Saint Francis Medical Center Midlothian, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Saint Mary's Hospital Richmond, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Brigham and Women's Hospital Boston, Massachusetts | |
| Brooke Army Medical Center Houston, Texas | |
| CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Québec, Quebec | |
| CHUM - Centre Hospitalier de l'Universite de Montreal Montreal, Quebec | |
| CIUSSSEMTL-Hopital Maisonneuve-Rosemont Montreal, Quebec | |
| Camden Clark Medical Center Parkersburg, West Virginia | Site Public Contact - (cancertrialsinfo@hsc.wvu.edu) |
| Cancer Care Center of O'Fallon O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Center of Western Wisconsin New Richmond, Wisconsin | Site Public Contact - (mmcorc@healthpartners.com) |
| Capital Health Medical Center-Hopewell Pennington, New Jersey | Site Public Contact - (clinicaltrials@capitalhealth.org) |
| Carle Cancer Center Urbana, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Effingham Effingham, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | Site Public Contact - (Research@carle.com) |
| Carle at The Riverfront Danville, Illinois | Site Public Contact - (Research@Carle.com) |
| Carlisle Regional Cancer Center Carlisle, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| CarolinaEast Medical Center New Bern, North Carolina | Site Public Contact - (lharrison@carolinaeasthealth.com) |
| Case Western Reserve University Cleveland, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| Castle Medical Center Kailua, Hawaii | |
| Cedars Sinai Medical Center Los Angeles, California | |
| Central Maryland Radiation Oncology in Howard County Columbia, Maryland | |
| Central Vermont Medical Center/National Life Cancer Treatment Berlin Corners, Vermont | |
| Chambersburg Hospital Chambersburg, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| Chelsea Hospital Chelsea, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Christiana Care Health System-Concord Health Center Chadds Ford, Pennsylvania | Site Public Contact - (lbarone@christianacare.org) |
| Christiana Care Health System-Wilmington Hospital Wilmington, Delaware | Site Public Contact - (lbarone@christianacare.org) |
| Clackamas Radiation Oncology Center Clackamas, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Cleveland Clinic Akron General Akron, Ohio | Site Public Contact - (CancerAnswer@ccf.org) |
| Cleveland Clinic Cancer Center Independence Independence, Ohio | Site Public Contact - (TaussigResearch@ccf.org) |
| Cleveland Clinic Cancer Center Mansfield Mansfield, Ohio | Site Public Contact - (TaussigResearch@ccf.org) |
| Cleveland Clinic Cancer Center Strongsville Strongsville, Ohio | Site Public Contact - (TaussigResearch@ccf.org) |
| Cleveland Clinic Cancer Center/Fairview Hospital Cleveland, Ohio | Site Public Contact - (TaussigResearch@ccf.org) |
| Cleveland Clinic Foundation Cleveland, Ohio | Site Public Contact - (TaussigResearch@ccf.org) |
| Cleveland Clinic Mercy Hospital Canton, Ohio | |
| Cleveland Clinic Wooster Family Health and Surgery Center Wooster, Ohio | Site Public Contact - (TaussigResearch@ccf.org) |
| Community Medical Center Missoula, Montana | Site Public Contact - (Lennette.Gonzales@rwjbh.org) |
| Condell Memorial Hospital Libertyville, Illinois | Site Public Contact - (advocateresearch@advocatehealth.com) |
| Corewell Health Beaumont Troy Hospital Troy, Michigan | |
| Corewell Health Dearborn Hospital Dearborn, Michigan | |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Lakeland Hospitals - Niles Hospital Niles, Michigan | |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health William Beaumont University Hospital Royal Oak, Michigan | |
| Crossroads Cancer Center Effingham, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Dana-Farber Cancer Institute Boston, Massachusetts | |
| Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Milford, Massachusetts | |
| Dana-Farber/Brigham and Women's Cancer Center at South Shore South Weymouth, Massachusetts | |
| Dartmouth Cancer Center - North Saint Johnsbury, Vermont | Site Public Contact - (cancer.research.nurse@hitchcock.org) |
| Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon, New Hampshire | Site Public Contact - (cancer.research.nurse@dartmouth.edu) |
| Decatur Memorial Hospital Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Delaware Health Center-Grady Cancer Center Delaware, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Doctors Hospital Columbus, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Drexel Town Square Health Center Oak Creek, Wisconsin | |
| Dublin Methodist Hospital Dublin, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Duluth Clinic Ashland Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Durham VA Medical Center Durham, North Carolina | Site Public Contact - (VHADURcancertrials@va.gov) |
| Edward Hospital/Cancer Center Naperville, Illinois | |
| Edwards Comprehensive Cancer Center Huntington, West Virginia | Site Public Contact - (Christina.Cole@chhi.org) |
| Elmhurst Memorial Hospital Elmhurst, Illinois | Site Public Contact - (Jrohde@emhc.org) |
| Emory Decatur Hospital Decatur, Georgia | Site Public Contact - (clinicaltrialsoncology@dekalbmedical.org) |
| Emory Proton Therapy Center Atlanta, Georgia | Site Public Contact - (allyson.anderson@emory.edu) |
| Emory Saint Joseph's Hospital Atlanta, Georgia | |
| Emory University Hospital Midtown Atlanta, Georgia | |
| Emory University Hospital/Winship Cancer Institute Atlanta, Georgia | |
| Ephrata Cancer Center Ephrata, Pennsylvania | |
| Essentia Health - Deer River Clinic Deer River, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Hibbing Clinic Hibbing, Minnesota | |
| Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Saint Mary's Hospital - Superior Superior, Wisconsin | |
| Essentia Health Saint Mary's Medical Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Sandstone Sandstone, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Virginia Clinic Virginia, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Hayward Clinic Hayward, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Spooner Clinic Spooner, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| FHCC at Northwest Hospital Seattle, Washington | |
| Fairview Southdale Hospital Edina, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Farmington Health Center Farmington, Utah | Site Public Contact - (cancerinfo@hci.utah.edu) |
| Fred Hutchinson Cancer Center Seattle, Washington | |
| Fresno Cancer Center Fresno, California | Site Public Contact - (Kpoct@kp.org) |
| Froedtert Menomonee Falls Hospital Menomonee Falls, Wisconsin | |
| Froedtert West Bend Hospital/Kraemer Cancer Center West Bend, Wisconsin | |
| Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center Danville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Genesys Hurley Cancer Institute Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| George Washington University Medical Center Washington D.C., District of Columbia | |
| Gibbs Cancer Center-Gaffney Gaffney, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Gibbs Cancer Center-Pelham Greer, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Goshen Center for Cancer Care Goshen, Indiana | Site Public Contact - (cccois@goshenhealth.com) |
| Grady Health System Atlanta, Georgia | |
| Grady Memorial Hospital Delaware, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Grant Medical Center Columbus, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| HSHS Saint Elizabeth's Hospital O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Hawaii Cancer Care - Westridge ‘Aiea, Hawaii | Site Public Contact - (info@hawaiicancercare.com) |
| Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii | Site Public Contact - (i.webster@hawaiicancercare.com) |
| Helen F Graham Cancer Center Newark, Delaware | Site Public Contact - (lbarone@christianacare.org) |
| Hi-Line Sletten Cancer Center Havre, Montana | Site Public Contact - (Roster@nrgoncology.org) |
| Highland Hospital Rochester, New York | |
| Hillcrest Hospital Cancer Center Mayfield Heights, Ohio | Site Public Contact - (TaussigResearch@ccf.org) |
| Huntsman Cancer Institute/University of Utah Salt Lake City, Utah | Site Public Contact - (cancerinfo@hci.utah.edu) |
| Hurley Medical Center Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Illinois CancerCare-Bloomington Bloomington, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Carthage Carthage, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Galesburg Galesburg, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Kewanee Clinic Kewanee, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Macomb Macomb, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Ottawa Clinic Ottawa, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Pekin Pekin, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peru Peru, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Princeton Princeton, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Intermountain Medical Center Murray, Utah | Site Public Contact - (officeofresearch@imail.org) |
| Jersey City Medical Center Jersey City, New Jersey | Site Public Contact - (Roster@nrgoncology.org) |
| Jupiter Medical Center Jupiter, Florida | Site Public Contact - (clinicaltrials@jupitermed.com) |
| Kaiser Permanente Cancer Treatment Center South San Francisco, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente Downtown Commons Sacramento, California | Site Public Contact - (kpoct@kp.org) |
| Kaiser Permanente Dublin Dublin, California | |
| Kaiser Permanente Fresno Orchard Plaza Fresno, California | |
| Kaiser Permanente Medical Center - Santa Clara Santa Clara, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente Medical Center-Vacaville Vacaville, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente Northwest Portland, Oregon | Site Public Contact - (information@kpchr.org) |
| Kaiser Permanente Oakland-Broadway Oakland, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente San Leandro San Leandro, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente- Marshall Medical Offices Redwood City, California | |
| Kaiser Permanente- Modesto MOB II Modesto, California | |
| Kaiser Permanente-Deer Valley Medical Center Antioch, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Fremont Fremont, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Fresno Fresno, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Modesto Modesto, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Oakland Oakland, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Richmond Richmond, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Roseville Roseville, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-San Francisco San Francisco, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Santa Rosa Santa Rosa, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Santa Teresa-San Jose San Jose, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-South Sacramento Sacramento, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-South San Francisco South San Francisco, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Stockton Stockton, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Vallejo Vallejo, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Walnut Creek Walnut Creek, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser San Rafael-Gallinas San Rafael, California | Site Public Contact - (Kpoct@kp.org) |
| Kantonsspital Aarau Aarau, | |
| Kapiolani Medical Center for Women and Children Honolulu, Hawaii | |
| LDS Hospital Salt Lake City, Utah | Site Public Contact - (officeofresearch@imail.org) |
| Lakeview Hospital Stillwater, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Langlade Hospital and Cancer Center Antigo, Wisconsin | Site Public Contact - (Juli.Alford@aspirus.org) |
| Lenox Hill Hospital New York, New York | |
| Lewis and Faye Manderson Cancer Center Tuscaloosa, Alabama | |
| Logan Regional Hospital Logan, Utah | Site Public Contact - (officeofresearch@imail.org) |
| Louis Stokes Cleveland VA Medical Center Cleveland, Ohio | Site Public Contact - (holly.henry@va.gov) |
| M D Anderson Cancer Center Houston, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson League City League City, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson West Houston Houston, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson in Sugar Land Sugar Land, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson in The Woodlands Conroe, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MaineHealth Cancer Care Center of York County Sanford, Maine | |
| MaineHealth Coastal Cancer Treatment Center Bath, Maine | Site Public Contact - (Roster@nrgoncology.org) |
| MaineHealth Maine Medical Center - Portland Portland, Maine | Site Public Contact - (clinicalresearch@mainehealth.org) |
| MaineHealth Maine Medical Center- Scarborough Scarborough, Maine | Site Public Contact - (clinicalresearch@mainehealth.org) |
| Manhattan Eye Ear and Throat Hospital New York, New York | |
| Mary Bird Perkins Cancer Center Baton Rouge, Louisiana | Site Public Contact - (clinicalresearch@marybird.com) |
| Mary Bird Perkins Cancer Center - Gonzales Gonzales, Louisiana | Site Public Contact - (clinicalresearch@marybird.com) |
| Maryland Proton Treatment Center Baltimore, Maryland | Site Public Contact - (info@mdproton.com) |
| McFarland Clinic - Ames Ames, Iowa | Site Public Contact - (ksoder@mcfarlandclinic.com) |
| McKay-Dee Hospital Center Ogden, Utah | Site Public Contact - (officeofresearch@imail.org) |
| McLeod Regional Medical Center Florence, South Carolina | Site Public Contact - (dorie.sturgill@mcleodhealth.org) |
| Medical College of Wisconsin Milwaukee, Wisconsin | |
| Medical Oncology Hematology Consultants PA Newark, Delaware | Site Public Contact - (lbarone@christianacare.org) |
| Memorial Hospital East Shiloh, Illinois | Site Public Contact - (dschwab@wustl.edu) |
| Memorial Hospital North Colorado Springs, Colorado | |
| Mercy Clinic-Rolla-Cancer and Hematology Rolla, Missouri | |
| Mercy Hospital Coon Rapids, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mercy Hospital Saint Louis St Louis, Missouri | |
| Mercy Hospital Springfield Springfield, Missouri | |
| MetroHealth Medical Center Cleveland, Ohio | Site Public Contact - (ababal@metrohealth.org) |
| Miller-Dwan Hospital Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Missouri Baptist Medical Center St Louis, Missouri | |
| Moffitt Cancer Center Tampa, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Moffitt Cancer Center - McKinley Campus Tampa, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Moffitt Cancer Center at SouthShore Ruskin, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Moffitt Cancer Center at Wesley Chapel Wesley Chapel, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Moffitt Cancer Center-International Plaza Tampa, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Monmouth Medical Center Long Branch, New Jersey | Site Public Contact - (mary.danish@rwjbh.org) |
| Munson Medical Center Traverse City, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| MyMichigan Medical Center Saginaw Saginaw, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Nebraska Medicine-Bellevue Bellevue, Nebraska | Site Public Contact - (unmcrsa@unmc.edu) |
| Nebraska Medicine-Village Pointe Omaha, Nebraska | |
| New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn, New York | Site Public Contact - (Adg9003@nyp.org) |
| Newark Beth Israel Medical Center Newark, New Jersey | Site Public Contact - (Christine.Kosmides@rwjbh.org) |
| North Coast Cancer Care Sandusky, Ohio | Site Public Contact - (TaussigResearch@ccf.org) |
| Northern Westchester Hospital Mount Kisco, New York | Site Public Contact - (AMellor@northwell.edu) |
| Northwell Health Cancer Institute at Huntington Greenlawn, New York | |
| Northwell Health Imbert Cancer Center Bay Shore, New York | |
| Northwell Health Physicians Partners Radiation Medicine at Queens Forest Hills, New York | |
| Northwell Health/Center for Advanced Medicine Lake Success, New York | |
| Northwest Wisconsin Cancer Center Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Northwestern Medicine Cancer Center Delnor Geneva, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Cancer Center Kishwaukee DeKalb, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Oak Brook Oak Brook, Illinois | Site Public Contact - (nctnprogram_rhlccc@northwestern.edu) |
| Northwestern University Chicago, Illinois | Site Public Contact - (cancer@northwestern.edu) |
| Noyes Memorial Hospital/Myers Cancer Center Dansville, New York | Site Public Contact - (WCICTOresearch@urmc.rochester.edu) |
| OSF Saint Francis Medical Center Peoria, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Odette Cancer Centre- Sunnybrook Health Sciences Centre Toronto, Ontario | |
| Ohio State University Comprehensive Cancer Center Columbus, Ohio | Site Public Contact - (Jamesline@osumc.edu) |
| OhioHealth Mansfield Hospital Mansfield, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| OhioHealth Marion General Hospital Marion, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Ottawa Hospital and Cancer Center-General Campus Ottawa, Ontario | |
| Pali Momi Medical Center ‘Aiea, Hawaii | |
| Pamela Youde Nethersole Eastern Hospital Chai Wan, | |
| Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| PeaceHealth Saint Joseph Medical Center Bellingham, Washington | Site Public Contact - (achapman1@peacehealth.org) |
| Penn State Milton S Hershey Medical Center Hershey, Pennsylvania | Site Public Contact - (CTO@hmc.psu.edu) |
| Phelps Health Delbert Day Cancer Institute Rolla, Missouri | Site Public Contact - (research@phelpshealth.org) |
| Phelps Memorial Hospital Center Sleepy Hollow, New York | |
| ProMedica Flower Hospital Sylvania, Ohio | Site Public Contact - (PCIOncResearch@promedica.org) |
| ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital Toledo, Ohio | Site Public Contact - (PCIOncResearch@promedica.org) |
| Providence Portland Medical Center Portland, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Providence Saint Vincent Medical Center Portland, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Queen's Cancer Cenrer - POB I Honolulu, Hawaii | |
| Queen's Cancer Center - Kuakini Honolulu, Hawaii | |
| Queen's Medical Center Honolulu, Hawaii | |
| Reading Hospital West Reading, Pennsylvania | |
| Regions Hospital Saint Paul, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Riverside Methodist Hospital Columbus, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Riverton Hospital Riverton, Utah | Site Public Contact - (officeofresearch@imail.org) |
| Rocky Mountain Cancer Centers-Penrose Colorado Springs, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Rohnert Park Cancer Center Rohnert Park, California | Site Public Contact - (Kpoct@kp.org) |
| Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey | |
| Rutgers New Jersey Medical School Newark, New Jersey | |
| SMC Center for Hematology Oncology Union Union, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Saint Barnabas Medical Center Livingston, New Jersey | Site Public Contact - (joanne.loeb@rwjbh.org) |
| Saint Charles Health System Bend, Oregon | Site Public Contact - (nosall@stcharleshealthcare.org) |
| Saint Francis Medical Center Cape Girardeau, Missouri | Site Public Contact - (sfmc@sfmc.net) |
| Saint George Regional Medical Center St. George, Utah | Site Public Contact - (officeofresearch@imail.org) |
| Saint Joseph Hospital Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Hospital East Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Radiation Oncology Resource Center Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Luke's Hospital of Duluth Duluth, Minnesota | Site Public Contact - (kdean@slhduluth.com) |
| Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin | Site Public Contact - (WI_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Sandra L Maxwell Cancer Center Cedar City, Utah | Site Public Contact - (officeofresearch@imail.org) |
| Sands Cancer Center Canandaigua, New York | |
| Sanford Joe Lueken Cancer Center Bemidji, Minnesota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford Roger Maris Cancer Center Fargo, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota | Site Public Contact - (OncologyClinicalTrialsSF@SanfordHealth.org) |
| Sechler Family Cancer Center Lebanon, Pennsylvania | Site Public Contact - (doxenberg@wellspan.org) |
| Self Regional Healthcare Greenwood, South Carolina | Site Public Contact - (nmcgaha@selfregional.org) |
| Sheboygan Physicians Group Sheboygan, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Siteman Cancer Center at Christian Hospital St Louis, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Siteman Cancer Center at Saint Peters Hospital City of Saint Peters, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Siteman Cancer Center at West County Hospital Creve Coeur, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Siteman Cancer Center-South County St Louis, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| South Sacramento Cancer Center Sacramento, California | Site Public Contact - (Kpoct@kp.org) |
| Southern Illinois University School of Medicine Springfield, Illinois | |
| Spartanburg Medical Center Spartanburg, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Springfield Memorial Hospital Springfield, Illinois | Site Public Contact - (pallante.beth@mhsil.com) |
| State University of New York Upstate Medical University Syracuse, New York | |
| Stony Brook University Medical Center Stony Brook, New York | |
| Straub Clinic and Hospital Honolulu, Hawaii | |
| The Cancer Center of Hawaii-Liliha Honolulu, Hawaii | |
| The James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky | |
| The Kirklin Clinic at Acton Road Birmingham, Alabama | Site Public Contact - (tmyrick@uab.edu) |
| The New York Hospital Medical Center of Queens Flushing, New York | Site Public Contact - (Roster@nrgoncology.org) |
| The Permanente Medical Group-Roseville Radiation Oncology Roseville, California | Site Public Contact - (Kpoct@kp.org) |
| The Queen's Medical Center - West Oahu ‘Ewa Beach, Hawaii | Site Public Contact - (rohta@queens.org) |
| The Research Institute of the McGill University Health Centre (MUHC) Montreal, Quebec | |
| The University of Kansas Cancer Center - Olathe Olathe, Kansas | Site Public Contact - (OlatheCCResearch@kumc.edu) |
| The Valley Hospital - Luckow Pavilion Paramus, New Jersey | Site Public Contact - (clinicaltrialsresearch@valleyhealth.com) |
| Torrance Memorial Physician Network - Cancer Care Torrance, California | Site Public Contact - (courtney.steeneken@tmphysicians.com) |
| Tower Cancer Research Foundation Beverly Hills, California | Site Public Contact - (towercancerresearch@toweroncology.com) |
| Trinity Health Medical Center - Brighton Brighton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Medical Center - Canton Canton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California | Site Public Contact - (ucstudy@uci.edu) |
| UCHealth Highlands Ranch Hospital Highlands Ranch, Colorado | |
| UCHealth Memorial Hospital Central Colorado Springs, Colorado | |
| UCHealth University of Colorado Hospital Aurora, Colorado | |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine, California | Site Public Contact - (ucstudy@uci.edu) |
| UH Seidman Cancer Center at Lake Health Mentor Campus Mentor, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| UH Seidman Cancer Center at UH Avon Health Center Avon, Ohio | |
| UHHS-Chagrin Highlands Medical Center Beachwood, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie, Maryland | |
| UM Capital Region Medical Center Largo, Maryland | Site Public Contact - (Sarah.Larson@umm.edu) |
| UM Upper Chesapeake Medical Center Bel Air, Maryland | |
| UPMC Cancer Center - Monroeville Monroeville, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| UPMC Cancer Center at UPMC Horizon Farrell, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg, Pennsylvania | |
| UPMC Hillman Cancer Center Erie Erie, Pennsylvania | Site Public Contact - (ClinicalResearchServices@upmc.edu) |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg, Pennsylvania | Site Public Contact - (haneydl@upmc.edu) |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg, Pennsylvania | Site Public Contact - (klitchfield@PINNACLEHEALTH.org) |
| UPMC-Heritage Valley Health System Beaver Beaver, Pennsylvania | Site Public Contact - (haneydl@upmc.edu) |
| UPMC-Magee Womens Hospital Pittsburgh, Pennsylvania | |
| UPMC-Passavant Hospital Pittsburgh, Pennsylvania | |
| UPMC-Saint Clair Hospital Cancer Center Pittsburgh, Pennsylvania | |
| UPMC-Saint Margaret Pittsburgh, Pennsylvania | |
| UPMC-Shadyside Hospital Pittsburgh, Pennsylvania | |
| University Health Network-Princess Margaret Hospital Toronto, Ontario | Site Public Contact - (clinical.trials@uhn.on.ca) |
| University Hospitals Parma Medical Center Parma, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| University Hospitals Portage Medical Center Ravenna, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| University of Alabama at Birmingham Cancer Center Birmingham, Alabama | Site Public Contact - (gingerreeves@uabmc.edu) |
| University of Arkansas for Medical Sciences Little Rock, Arkansas | |
| University of Hawaii Cancer Center Honolulu, Hawaii | |
| University of Illinois Chicago, Illinois | |
| University of Kansas Cancer Center Kansas City, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center - Lee's Summit Lee's Summit, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center - North Kansas City, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center-Overland Park Overland Park, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Health System Saint Francis Campus Topeka, Kansas | |
| University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Maryland Shore Medical Center at Easton Easton, Maryland | Site Public Contact - (Christina.weisenborn@umm.edu) |
| University of Maryland/Greenebaum Cancer Center Baltimore, Maryland | |
| University of Michigan - Brighton Center for Specialty Care Brighton, Michigan | |
| University of Michigan Health - Sparrow Lansing Lansing, Michigan | Site Public Contact - (harsha.trivedi@umhsparrow.org) |
| University of Michigan Health - West Wyoming, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| University of Michigan Rogel Cancer Center Ann Arbor, Michigan | Site Public Contact - (CancerAnswerLine@med.umich.edu) |
| University of Nebraska Medical Center Omaha, Nebraska | Site Public Contact - (unmcrsa@unmc.edu) |
| University of New Mexico Cancer Center Albuquerque, New Mexico | Site Public Contact - (HSC-ClinicalTrialInfo@salud.unm.edu) |
| University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma | Site Public Contact - (ou-clinical-trials@ouhsc.edu) |
| University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania | |
| University of Rochester Rochester, New York | |
| University of Utah Sugarhouse Health Center Salt Lake City, Utah | Site Public Contact - (cancerinfo@hci.utah.edu) |
| University of Vermont Medical Center Burlington, Vermont | Site Public Contact - (rpo@uvm.edu) |
| University of Vermont and State Agricultural College Burlington, Vermont | Site Public Contact - (rpo@uvm.edu) |
| University of Washington Medical Center - Montlake Seattle, Washington | |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison, Wisconsin | Site Public Contact - (clinicaltrials@cancer.wisc.edu) |
| University of Wisconsin Carbone Cancer Center - Johnson Creek Johnson Creek, Wisconsin | Site Public Contact - (clinicaltrials@cancer.wisc.edu) |
| University of Wisconsin Carbone Cancer Center - University Hospital Madison, Wisconsin | Site Public Contact - (clinicaltrials@cancer.wisc.edu) |
| UofL Health Medical Center Northeast Louisville, Kentucky | Site Public Contact - (ctoinfo@louisville.edu) |
| Upstate Cancer Center Radiation Oncology at Oswego Oswego, New York | Site Public Contact - (BinghamE@upstate.edu) |
| Upstate Cancer Center at Hill Radiation Oncology Syracuse, New York | Site Public Contact - (BinghamE@upstate.edu) |
| Upstate Cancer Center at Oswego Oswego, New York | Site Public Contact - (McDowelE@upstate.edu) |
| Upstate Cancer Center at Verona Verona, New York | Site Public Contact - (McDowelE@upstate.edu) |
| Utah Valley Regional Medical Center Provo, Utah | Site Public Contact - (officeofresearch@imail.org) |
| VCU Massey Cancer Center at Hanover Medical Park Mechanicsville, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| VCU Massey Cancer Center at Stony Point Richmond, Virginia | Site Public Contact - (ctoclinops@vcu.edu) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| Veterans Administration Medical Center-Baltimore Baltimore, Maryland | |
| Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Vince Lombardi Cancer Clinic-Sheboygan Sheboygan, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Vince Lombardi Cancer Clinic-Two Rivers Two Rivers, Wisconsin | Site Public Contact - (ncorp@aurora.org) |
| Washington Hospital Fremont, California | |
| Washington University School of Medicine St Louis, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| WellSpan Health-York Cancer Center York, Pennsylvania | |
| WellSpan Health-York Hospital York, Pennsylvania | |
| West Virginia University Healthcare Morgantown, West Virginia | Site Public Contact - (cancertrialsinfo@hsc.wvu.edu) |
| Westchester Medical Center Valhalla, New York | Site Public Contact - (Roster@nrgoncology.org) |
| Wheeling Hospital/Schiffler Cancer Center Wheeling, West Virginia | |
| Wilcox Memorial Hospital and Kauai Medical Clinic Lihue, Hawaii | |
| Wilmot Cancer Institute at Webster Webster, New York | Site Public Contact - (WCICTOresearch@urmc.rochester.edu) |
| Zablocki Veterans Administration Medical Center Milwaukee, Wisconsin |