StudyFinder
Search Results
Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.
Search all categories
630 Study Matches
NS-089/NCNP-02-201 in Boys With Duchenne Muscular Dystrophy (DMD)
Trial info - trialinfo@nspharma.com
NCT05996003
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Male ≥ 4 years and \<15 years of age
* Confirmed DMD mutation(s) in the dystrophin gene that is amenable to skipping of exon 44 to restore the dystrophin mRNA reading frame
* Able to walk independently without assistive devices
* Ability to complete the TTSTAND without assistance in \<20 seconds
* Stable dose of glucocorticoid for at least 3 months and the dose is expected to remain on a stable dose for the duration of the study.
* Other inclusion criteria may apply.
Exclusion Criteria:
* Has a body weight of \<20 kg at the time of informed consent (applies to participants screening for Part 1 only)
* Evidence of symptomatic cardiomyopathy
* Current or previous treatment with anabolic steroids (e.g., oxandrolone) or products containing resveratrol or adenosine triphosphate within 3 months prior to first dose of study drug
* Current or previous treatment with any other investigational drug within 3 months prior to the first dose of study drug or within 5 times the half-life of a medication, whichever is longer
* Surgery within the 3 months prior to the first dose of study drug or planned during the study duration
* Previously treated in an interventional study of NS-089/NCNP-02
* Having taken any gene therapy.
* Having received exon skipping oligonucleotide within 1 year prior to the first dose of IP or is expected to receive exon skipping oligonucleotide prior to completion of study.
* Other exclusion criteria may apply. DRUG: NS-089/NCNP-02
Duchenne Muscular Dystrophy, Exon 44, DMD
Exon 44 Skipping, DMD
I'm interested
Share via email
Show 17 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Alberta Children's Hospital Calgary, Alberta | Julie Dao - (julie.dao@ucalgary.ca) |
| Ann and Robert H. Lurie Children's Hospital of Chicago Chicago, Illinois | Raven Hill - (rhill@luriechildrens.org) Alka Maheshwari - (amaheshwari@luriechildrens.org) |
| Children's Hospital Colorado Aurora, Colorado | Hannah Kleiner - (hannah.kleiner@childrenscolorado.org) |
| Cincinnati Children's Hospital Medical Center Cincinnati, Ohio | Angela Edmondson - (Angela.Edmondson@cchmc.org) |
| London Health Sciences Centre London, | Teresa Longfield - (teresa.longfield@lhsc.on.ca) |
| NHO Osaka Toneyama Medical Center Toyonaka, Osaka | Clinical Trial Office - (410-chiken@mail.hosp.go.jp) |
| National Center of Neurology and Psychiatry Kodaira, Tokyo | |
| National Hospital Organization Nagara Medical Center Nagara, Gifu-shi, Gifu | Clinical Trial Management Office - (yonekura.kei.wu@mail.hosp.go.jp) |
| Pusan National University Yangsan Hospital Yangsan, Gyeongsangnam-do | JaeYoon Kim - (lusterwuzz@naver.com) |
| Rare Disease Research Atlanta, Georgia | Julia Zhu - (julia.zhu@rarediseaseresearch.com) |
| Rare Disease Research, LLC - FL Kissimmee, Florida | Marcial Almaraz - (marcial.almaraz@rarediseaseresearch.com) |
| Seoul National University Hospital Seoul, | Hyeon Ju Kwon - (hjkwon@snuh.org; 49041@snuh.org) |
| Shiga General Hospital Moriyama-shi, Shiga | Children's Building - (kenji.s.address@gmail.com) |
| UT Southwestern/Children's Health Dallas, Texas | Deniece Winston - (Deniece.Winston@UTSouthwestern.edu) |
| University of Kansas Medical Center (KUMC) Kansas City, Kansas | Rebecca Clay - (rclay@kumc.edu) |
| University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania | Vibha Chauhan - (vibha.chauhan@chp.edu) |
| Virginia Commonwealth University Health System Richmond, Virginia | Andrea Jewell - (andrea.jewell@vcuhealth.org) |
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer (SUNRAY-02)
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or - LillyTrials@Lilly.com
NCT06890598
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Histological or cytological confirmation of NSCLC.
* Part A
• Clinical Stage II-IIIB (N2) treated with presurgical chemoimmunotherapy, with residual tumor present at time of surgery. Patients with a pathologic complete response are not eligible.
• Pathologic Stage II-IIIB (N2) NSCLC treated with initial upfront resection. * Part B - Clinical Stage III, unresectable NSCLC, without progression on concurrent platinum-based chemoradiotherapy. * Must have disease with evidence of KRAS G12C mutation. * Must have known programmed death-ligand 1 (PD-L1) expression * Must have an ECOG performance status of 0 or 1. * Able to swallow oral medication. * Must have adequate laboratory parameters. * Contraceptive use should be consistent with local regulations for those participating in clinical studies. * Women of childbearing potential must * Have a negative pregnancy test. * Not be breastfeeding during treatment
Exclusion Criteria:
* Have known changes in the EGFR or ALK genes.
* Have another type of cancer that is progressing or required active treatment within the past 3 years before screening.
* Have an active autoimmune disease that required systemic treatment in the past 2 years. Endocrine replacement therapy is allowed.
* Had any immune-related side effect or allergic reaction (Grade 3 or higher) from a previous immunotherapy medicine, or any immune-related side effect greater than Grade 1 that has not resolved. This does not apply for people with hormone-related diseases who are now on stable hormone replacement therapy. DRUG: Olomorasib, DRUG: Pembrolizumab, DRUG: Durvalumab, DRUG: Placebo
Carcinoma, Non-Small-Cell Lung
I'm interested
Share via email
Show 348 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| AHN Allegheny General Hospital Pittsburgh, Pennsylvania | |
| ASST Grande Ospedale Metropolitano Niguarda Milan, | |
| AZ Delta vzw Roeselare, | |
| Adana City Hospital Adana, | |
| Agios Loukas Clinic Thessaloniki, | |
| Agios Savvas Regional Cancer Hospital Athens, | |
| Aichi Cancer Center Hospital Aichi, Nagoya, | |
| Amphia Ziekenhuis, locatie Breda Molengracht Breda, | |
| Amsterdam UMC, locatie VUmc Amsterdam, | |
| Antalya Egitim ve Arastırma Hastanesi Antalya, | |
| Antwerp University Hospital Edegem, Antwerp | |
| Anyang Cancer Hospital Anyang, | |
| Asan Medical Center Seoul, | |
| Asklepios Fachkliniken München-Gauting Gauting, | |
| Asklepios Klinik Harburg Hamburg, | |
| Assistance Publique Hopitaux de Marseille - Hopital Nord Marseille, | |
| Austin Health Heidelberg, Victoria | |
| Azienda Ospedaliera Dei Colli Naples, | |
| Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento Verona, | |
| Azienda Sanitaria Ospedaliera S Luigi Gonzaga Orbassano, | |
| BASS Cancer Center Walnut Creek, California | |
| Baptist Health Hamburg Lexington, Kentucky | |
| Baptist Health Lexington Lexington, Kentucky | |
| Baskent University Dr. Turgut Noyan Research and Training Center Adana, | |
| Beijing Cancer Hospital Beijing, | |
| Boca Raton Regional Hospital Boca Raton, Florida | |
| Bradfordhill Santiago, | |
| Budapesti Uzsoki Utcai Korhaz Budapest, | |
| Buddhist Dalin Tzu Chi General Hospital Chiayi City, | |
| CHI Saint Joseph Cancer Center - East Lexington, Kentucky | |
| CHIREC - site delta Auderghem, | |
| CHU Bordeaux Haut-Leveque Pessac, | |
| CHU Grenoble Alpes La Tronche, | |
| CHU de Toulouse - Hopital Larrey Toulouse, | |
| CHUS - Hospital Clinico Universitario Santiago de Compostela, | |
| CTO - Centro de Tratamento Oncológico Belém, | |
| Cancer Care Northwest - Vercler Spokane Valley, Washington | |
| Cancer Hospital Chinese Academy of Medical Science Beijing, | |
| Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center Shenzhen, | |
| Cancer Hospital of Shantou University Medical College Shantou, | |
| Captain James A. Lovell Federal Health Care Center North Chicago, Illinois | |
| Centre Antoine-Lacassagne Nice, | |
| Centre Hospitalier Universitaire de Poitiers Poitiers, | |
| Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou Rennes, | |
| Centre Leon Berard Lyon, | |
| Centro Hospitalar E Universitário De Coimbra Coimbra, | |
| Centro Paulista de Oncologia Clínica São Paulo, | |
| Centro de Oncología de Precisión Santiago, | |
| Centro de Pesquisa Clínica do Instituto do Câncer do Ceará Fortaleza, | |
| Centro de Pesquisa Sao Lucas Campinas, | |
| Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA Rio de Janeiro, | |
| Chang Gung Medical Foundation-LinKou Branch Taoyuan District, | |
| Chang Gung Memorial Hospital at Kaohsiung Kaohsiung City, | |
| Changhua Christian Hospital Changhua County, | |
| Chi Mei Hospital - Liouying Branch Tainan City, | |
| Chi Mei Medical Center Tainan, Tainan | |
| China-Japan Friendship Hospital Beijing, | |
| Chonnam National University Hwasun Hospital Hwasun-gun, | |
| Chung Shan Medical University Hospital Taichung, | |
| Chungbuk National University Hospital Chungju, | |
| Clearview Cancer Institute Huntsville, Alabama | |
| Cleveland Clinic Cleveland, Ohio | |
| Columbia University Irving Medical Center New York, New York | |
| Complejo Hospitalario de Navarra Pamplona, | |
| Comprehensive Hematology Oncology St. Petersburg, Florida | |
| DRK Kliniken Berlin Mitte Berlin, | |
| Deenanath Mangeshkar Hospital & Research Centre Pune, | |
| Drammen Sykehus, Vestre Viken HF Drammen, | |
| E-DA Hospital Kaohsiung City, | |
| ETZ Elisabeth Tilburg, | |
| Errikos Dunant Hospital Center Athens, | |
| European Interbalkan Medical Center Thessaloniki, | |
| Evangelische Lungenklinik Berlin Berlin, | |
| Evangelisches Krankenhaus Herne - Eickel Herne, | |
| FALP Santiago, | |
| Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica Banská Bystrica, | |
| Fakultni nemocnice Bulovka Prague, | |
| Far Eastern Memorial Hospital New Taipei City, | |
| Farkasgyepui Tudogyogyintezet Farkasgyepű, | |
| Florida Cancer Specialists - South Fort Myers, Florida | |
| Florida Cancer Specialists East West Palm Beach, Florida | |
| Florida Cancer Specialists North St. Petersburg, Florida | |
| Franciscan Health Indianapolis, Indiana | |
| Franziskus-Hospital Harderberg Georgsmarienhütte, | |
| Fudan University Shanghai Cancer Center Shanghai, Shanghai Municipality | |
| Fundação Pio XII - Hospital de Câncer de Barretos Barretos, São Paulo | |
| Galaxy Superspeciality Hospital Aurangabad, | |
| Gangnam Severance Hospital, Yonsei University Health System Seoul, | |
| Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi Gaziantep, | |
| Goulburn Valley Health Shepparton, | |
| Groupe hospitalier Paris saint Joseph Paris, | |
| Guangdong Provincial People's Hospital Guangzhou, | |
| Guangxi Medical University Affiliated Tumor Hospital Nanning, Guangxi | |
| Gustave Roussy Villejuif, | |
| H.R.U Málaga - Hospital General Málaga, | |
| HELIOS Klinikum Erfurt Erfurt, | |
| HFR Fribourg - Hôpital cantonal Fribourg, | |
| Harbin Medical University Cancer Hospital Harbin, Heilongjiang | |
| Hartford Hospital (HH) Hartford, Connecticut | |
| Haukeland Universitetssjukehus Bergen, | |
| Heartlands Hospital Birmingham, | |
| Hemato Oncology Clinic Ahmedabad, | |
| Highlands Oncology Group Springdale, Arkansas | |
| Himeji Medical Center Himeji, | |
| Hokkaido University Hospital Hokkaido, Sapporo, | |
| Hospices Civils de Lyon - Hopital Louis Pradel Bron, | |
| Hospital Clinic de Barcelona Barcelona, | |
| Hospital Clinico Universitario Lozano Blesa Zaragoza, | |
| Hospital Clinico de Valencia Valencia, | |
| Hospital Cuf porto Porto, | |
| Hospital General Universitario Gregorio Marañon Madrid, | |
| Hospital Infanta Cristina Badajoz, | |
| Hospital Insular de Gran Canaria Las Palmas de Gran Canaria, | |
| Hospital Jerez de la Frontera Jerez de la Frontera, | |
| Hospital Santa Catarina - Paulista São Paulo, | |
| Hospital Sao Lucas da PUCRS Porto Alegre, | |
| Hospital Sirio Libanes São Paulo, | |
| Hospital Tacchini Bento Gonçalves, | |
| Hospital Universitari Son Espases Palma de Mallorca, | |
| Hospital Universitari Vall d'Hebron Barcelona, | |
| Hospital Universitario 12 de Octubre Madrid, | |
| Hospital Universitario Quironsalud Madrid Pozuelo de Alarcón, | |
| Hospital Universitario Ramon y Cajal Madrid, | |
| Hospital Universitario Virgen del Rocio Seville, | |
| Hospital da Luz Lisboa Lisbon, | |
| Hospital de Cancer de Londrina Londrina, | |
| Houston Methodist Hospital Houston, Texas | |
| Hualien Tzu Chi Medical Center Hualien City, | |
| Hubei Cancer Hospital Wuhan, | |
| Huddersfield Royal Infirmary Huddersfield, | |
| Hunan Cancer Hospital Changsha, Hunan | |
| Hunan Cancer Hospital Changsha, Hunan | |
| Hôpital Européen Georges Pompidou Paris, | |
| Hôpital Robert Schuman Vantoux, | |
| ICON Cancer Centre - Kurralta Park Kurralta Park, | |
| Icesp - Instituto Do Câncer Do Estado de São Paulo São Paulo, | |
| Icon Cancer Centre Wesley Auchenflower, | |
| Institut Curie Paris, | |
| Institut Jean Godinot Reims, | |
| Institut de Cancerologie de l'Ouest Saint-Herblain, | |
| Instituto Catalan de Oncologia - Hospital Duran i Reynals Hospitalet, | |
| Instituto D'Or Pesquisa e Ensino Rio de Janeiro, | |
| Instituto D'Or de Pesquisa e Ensino (IDOR) São Paulo, | |
| Instituto Português de Oncologia do Porto Francisco Gentil, EPE Porto, | |
| Instituto Tumori Giovanni Paolo II Bari, | |
| Institutul Oncologic Cluj-Napoca, | |
| Isala, locatie Zwolle Zwolle, | |
| Istituto Nazionale Tumori Regina Elena Rome, | |
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola, | |
| Izmir Atatürk Training and Research Hospital Izmir, | |
| Jefferson Health - Cherry Hill Cherry Hill, New Jersey | |
| Jefferson Hospital Northeast Philadelphia, Pennsylvania | |
| Jilin Cancer Hospital Changchun, | |
| Jinan Central Hospital Jinan, | |
| John Theurer Cancer Center at Hackensack University Medical Center Hackensack, New Jersey | |
| Johns Hopkins Bayview Medical Center Baltimore, Maryland | |
| Juntendo University Hospital Bunkyo-ku, Tokyo | |
| K2 Oncology Providencia, | |
| Kaiser Permanente Interstate Medical Office Central Portland, Oregon | |
| Kaiser Permanente San Diego Mission Road San Diego, California | |
| Kanagawa Cancer Center Yokohama, Kanagawa | |
| Kanagawa Cardiovascular and Respiratory Center Kanagawa, Yokohama, | |
| Kanazawa University Hospital Kanazawa, | |
| Kansai Medical University Hospital Hirakata, Osaka | |
| Kantonsspital Baden Baden, | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung City, | |
| Karmanos Cancer Institute Detroit, Michigan | |
| Keimyung University Dongsan Hospital Daegu, | |
| Klinik Floridsdorf Vienna, | |
| Klinikum Chemnitz Chemnitz, | |
| Klinikum Koln-Merheim Cologne, | |
| Klinikum Nürnberg Nord Nuremberg, | |
| Konkuk University Medical Center Seoul, | |
| Korea University Guro Hospital Seoul, | |
| Kouros Moccia Oncologia Locarno, | |
| Krankenhaus Martha-Maria Halle-Dölau Halle, | |
| Kyungpook National University Chilgok Hospital Daegu, | |
| Kyushu University Hospital Fukuoka, Fukuoka, | |
| Latrobe Regional Health Traralgon, | |
| Lexington Medical Center West Columbia, South Carolina | |
| Liga Norte Riograndense Contra O Cancer Natal, Rio Grande do Norte | |
| Liuzhou People's Hospital Liuzhou, | |
| Lotus-Med Bucharest, | |
| LungenClinic Grosshansdorf Großhansdorf, | |
| MV-Zentrum für Onkologie und Hämatologie Cologne, | |
| Malabar Cancer Centre - Thalassery Thalassery, | |
| Marmara Universitesi Pendik Egitim Arastirma Hastanesi Pendik, | |
| Mary Bird Perkins Cancer Center Baton Rouge, Louisiana | |
| Medical College of Wisconsin Milwaukee, Wisconsin | |
| Medical University of South Carolina Charleston, South Carolina | |
| Medipoint Hospitals Pvt. Ltd. Pune, | |
| Medizinische Universität Graz Graz, | |
| Meir Medical Center Kfar Saba, | |
| Memorial Sloan Kettering Cancer Center New York, New York | |
| Miami Cancer Institute at Baptist Health, Inc. Miami, Florida | |
| Missouri Baptist Medical Center St Louis, Missouri | |
| Miyagi Cancer Center Natori, | |
| Moffitt Cancer Center Tampa, Florida | |
| NHO Kinki Chuo Chest Medical Center Sakai, | |
| National Cancer Center Gyeonggi-do, | |
| National Cancer Center Hospital East Chiba, Kashiwa, | |
| National Cheng Kung University Hospital Tainan, | |
| National Taiwan University Cancer Center (NTUCC) Taipei, | |
| National Taiwan University Hospital Taipei, | |
| National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region Douliu, | |
| Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL) Amsterdam, | |
| Nemocnice AGEL Ostrava - Vitkovice a.s. Ostrava, | |
| New England Cancer Specialists Westbrook, Maine | |
| New Taipei Municipal TuCheng Hospital New Taipei City, | |
| Niigata Cancer Center Hospital Niigata, | |
| Northport VA Medical Center Northport, New York | |
| Northwest Cancer Specialists PC Vancouver, Washington | |
| Ochsner Clinic Foundation Jefferson, Louisiana | |
| Ochsner Health Ochsner Cancer Center - Baton Rouge Baton Rouge, Louisiana | |
| Oncocentro de Minas Gerais Belo Horizonte, | |
| One Day Med Szczecin, | |
| Onkologiezentrum Donauwörth Donauwörth, | |
| Ordensklinikum Linz GmbH Elisabethinen Linz, | |
| Oregon Health and Science University Portland, Oregon | |
| Orszagos Onkologiai Intezet Budapest, | |
| Oslo universitetssykehus, Radiumhospitalet Oslo, | |
| Ospedale San Gerardo-ASST Monza Monza, | |
| Ospedale San Martino Genova, | |
| Ovidius Clinical Hospital OCH Ovidiu, | |
| Pacific Medical College & Hospital Udaipur, | |
| Parc de Salut Mar - Hospital del Mar Barcelona, | |
| Parkview Research Center at Parkview Regional Medical Center Fort Wayne, Indiana | |
| Peking University People's Hospital Beijing, | |
| Policlinico "G. Rodolico" Catania, | |
| Profound Research LLC Oceanside, California | |
| Providence Portland Medical Center Portland, Oregon | |
| Providence St. Vincent Medical Center Portland, Oregon | |
| Pusan National University Hospital Seogu, Busan Gwang'yeogsi | |
| Pusan National University Yangsan Hospital Yangsan, Gyeongsangnam-do | |
| Rajiv Gandhi Government General Hospital Chennai, | |
| Rambam Health Care Campus Haifa, | |
| Regional Cancer Centre - Thiruvananthapuram Thiruvananthapuram, | |
| Reliant Medical Group Worcester, Massachusetts | |
| Robert Bosch Krankenhaus GmbH Stuttgart, | |
| Royal Marsden Hospital (Chelsea) London, | |
| Royal Marsden Hospital (Sutton) Sutton, | |
| SC Memorial Healthcare International SRL Bucharest, | |
| SCRI Oncology Partners Nashville, Tennessee | |
| Sahlgrenska Universitetssjukhuset Gasteborg, | |
| Saitama Medical University International Medical Center Saitama, | |
| Sakarya University School of Medicine Adapazarı, | |
| Samsun Medical Park Hastanesi Samsun, | |
| Samsung Medical Center Seoul, | |
| Sarah Cannon Research Institute London, England | |
| Savera Cancer & Multi Speciality Hospital Patna, | |
| Seoul National University Bundang Hospital Seongnam-si, | |
| Severance Hospital, Yonsei University Health System Seoul, | |
| Shaare Zedek Medical Center Jerusalem, | |
| Shandong Cancer Hospital Jinan, Shandong | |
| Shanghai Chest Hospital Shanghai, | |
| Sheba Medical Center Ramat Gan, | |
| Shenzhen People's Hospital Shenzhen, | |
| Shizuoka Cancer Center Shizuoka, | |
| Sibley Memorial Hospital Washington D.C., District of Columbia | |
| Sichuan Cancer Hospital Chengdu, | |
| Sidney Kimmel Cancer Center - Washington Township Sewell, New Jersey | |
| Sir Charles Gairdner Hospital Nedlands, Western Australia | |
| Sir H. N. Reliance Foundation Hospital and Research Centre Mumbai, Maharashtra | |
| Sorlandet Sykehus Arendal Arendal, | |
| Springfield Clinic Main Campus Springfield, Illinois | |
| St. Antonius Ziekenhuis, locatie Utrecht Utrecht, | |
| St. Elisabeth-Krankenhaus Leipzig Leipzig, | |
| Stanford Cancer Center Palo Alto, California | |
| Sunshine Coast University Hospital Birtinya, Queensland | |
| Swedish Cancer Institute - Edmonds Edmonds, Washington | |
| Swedish Medical Center Englewood, Colorado | |
| Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej Kielce, | |
| Sykehuset Innlandet HF Gjøvik Gjøvik, | |
| Taichung Veterans General Hospital Taichung, China | |
| Taipei Veterans General Hospital Taipei, Beitou District / R.o.c. | |
| Taizhou Hospital of Zhejiang Province Taizhou, | |
| Tamworth Hospital North Tamworth, | |
| Tata Memorial Centre - Homi Bhabha Cancer Hospital Varanasi, | |
| Tennessee Oncology Nashville, Tennessee | |
| Tennessee Oncology Chattanooga Chattanooga, Tennessee | |
| Thangam Cancer Center - Namakkal Namakkal, | |
| The Cancer Institute Hospital of JFCR Tokyo, | |
| The Catholic Univ. of Korea Seoul St. Mary's Hospital Seoul, | |
| The Catholic University Of Korea St. Vincent's Hospital Suwon, | |
| The Catholic University of Korea, Eunpyeong St. Mary's Hospital Seoul, Eunpyeong-gu | |
| The Catholic University of Korea, Incheon St. Mary's Hospital Incheon, | |
| The Catholic University of Korea, Yeouido St. Mary's Hospital Seoul, | |
| The Center for Cancer and Blood Disorders Fort Worth, Texas | |
| The Christie NHS Foundation Trust Manchester, | |
| The First Affiliated Hospital of Guangzhou Medical University Guangzhou, | |
| The First Affiliated Hospital of Henan University of Science &Technology Luoyang, | |
| The First Affiliated Hospital of Soochow University Suzhou, Jiangsu | |
| The First Affiliated Hospital of Xi'An Jiaotong University Xi’an, Shanxi | |
| The First People's Hospital of Foshan Foshan, | |
| The Second Affiliated Hospital Chongqing Medical University Chongqing, | |
| The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou, Zhejiang | |
| The Second People's Hospital of Neijiang Neijiang, | |
| The Third People's Hospital of Chengdu (CDTPH) Chengdu, | |
| The University of Arizona Cancer Center - North Campus Tucson, Arizona | |
| The University of Vermont Medical Center Inc. Burlington, Vermont | |
| Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office Philadelphia, Pennsylvania | |
| Thoracic General Hospital of Athens "I Sotiria" Athens, | |
| Thoraxklinik-Heidelberg gGmbH Heidelberg, | |
| Tianjin Medical University Cancer Institute & Hospital Tianjin, Tianjin Municipality | |
| Tianjin Medical University Cancer Institute & Hospital Tianjin, Tianjin Municipality | |
| Tokyo Metropolitan Komagome Hospital Bunkyō City, | |
| Tongji Hospital Tongji Medical,Science & Technology Wuhan, Hubei | |
| Torbay Hospital Torquay, | |
| Tottori University Hospital Yonago, Tottori | |
| Trakya University Edirne, | |
| UCLA Hematology/Oncology - Santa Monica Los Angeles, California | |
| USO - Texas Oncology - San Antonio San Antonio, Texas | |
| USO - Texas Oncology Gulf Coast Sugar Land, Texas | |
| USO - US Oncology Research Network The Woodlands, Texas | |
| UZ Leuven Leuven, | |
| Universitaetsklinikum Tuebingen Tübingen, | |
| University General Hospital of Heraklion Heraklion, Crete, | |
| University General Hospital of Larissa Larissa, | |
| University Hospital and UW Health Clinics Madison, Wisconsin | |
| University Hospital of Patras Pátrai, | |
| University Hospital,Kyoto Prefectural University of Medicine Kyoto, | |
| University Hospitals Sussex NHS Foundation Trust East Sussex, | |
| University of Alabama at Birmingham Birmingham, Alabama | |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center Orange, California | |
| University of Chicago Medical Center Chicago, Illinois | |
| University of Florida - Jacksonville Jacksonville, Florida | |
| University of Illinois at Chicago Chicago, Illinois | |
| University of Maryland Baltimore, Maryland | |
| University of Tennessee Medical Center Knoxville, Tennessee | |
| University of Texas MD Anderson Cancer Center Houston, Texas | |
| University of Virginia Health System Charlottesville, Virginia | |
| Univerzitná nemocnica Bratislava - Nemocnica Ružinov Bratislava, | |
| VCU Health Adult Outpatient Pavillion Richmond, Virginia | |
| Vivantes Klinikum im Friedrichshain - Landsberger Allee Berlin, | |
| Vychodoslovensky Onkologicky ustav a.s. Košice, | |
| Wakayama Medical University Hospital Wakayama, | |
| West China Hospital, Sichuan University Chengdu, Sichuan | |
| Wielkopolskie Centrum Pulmonologii i Torakochirurgii Poznan, | |
| Xiangya Hospital Central South University Changsha, | |
| Xiangya Hospital Central South University Changsha, | |
| Yeungnam Univeristy Medical Center Nam-gu, | |
| Zhejiang Cancer Hospital Zhejiang, | |
| Zhejiang Cancer Hospital Zhejiang, | |
| Zhejiang Provincial People's Hospital Hangzhou, | |
| Zhongshan Peoples Hospital Zhongshan, | |
| ZhuZhou Central Hospital Zhuzhou, | |
| Ziekenhuis St. Jansdal Harderwijk, | |
| İ.A.Ü VM Medical Park Florya Hastanesi Istanbul, |
The CONFORM Pivotal Trial
Aly Dechert, MS - adechert@conformalmedical.com
NCT05147792
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
• Male or non-pregnant female aged ≥18 years
• Documented non-valvular AF (paroxysmal, persistent, or permanent)
• High risk of stroke or systemic embolism, defined as CHA2DS2-VASc score of ≥ 3
• Has an appropriate rationale to seek a non-pharmacologic alternative to long-term oral anticoagulation
• Deemed by the site investigator to be suitable for short term oral anticoagulation therapy but deemed less favorable for long-term oral anticoagulation therapy.
• Deemed appropriate for LAA closure by the site investigator and a clinician not a part of the procedural team using a shared decision-making process in accordance with standard of care
• Able to comply with the protocol-specified medication regimen and follow-up evaluations
• The subject (or legally authorized representative, where allowed) has been informed of the nature of the study, agrees to its provisions, and has provided written informed consent approved by the appropriate institutional review board (IRB)/Regional Ethics Board (REB)/Ethics Committee (EC).
Exclusion Criteria:
• Pregnant or nursing patients and those who plan pregnancy in the period up to one year following the index procedure. Female patients of childbearing potential must have a negative pregnancy test (per site standard test) within 7 days prior to index procedure.
• Anatomic conditions that would prevent performance of an LAA occlusion procedure (e.g., atrial septal defect (ASD) requiring closure, high-risk patent foramen ovale (PFO) requiring closure, a highly mobile inter-atrial septal aneurysm precluding a safe TSP, presence of a PFO/ASD closure device, history of surgical ASD repair or history of surgical LAAO closure)
• Atrial fibrillation that is defined by a single occurrence or that is transient or reversible (e.g., secondary thyroid disorders, acute alcohol intoxication, trauma, recent major surgical procedures)
• A medical condition (other than atrial fibrillation) that mandates long-term oral anticoagulation (e.g., history of unprovoked deep vein thrombosis or pulmonary embolism, or prosthetic mechanical heart valve)
• History of bleeding diathesis or coagulopathy, or patients in whom antiplatelet and/or anticoagulant therapy is contraindicated
• Documented active systemic infection
• Symptomatic carotid artery disease (defined as \>50% stenosis with symptoms of ipsilateral transient or visual TIA evidenced by amaurosis fugax, ipsilateral hemispheric TIAs or ipsilateral stroke); if subject has a history of carotid stent or endarterectomy the subject is eligible if there is \<50% stenosis noted at the site of prior treatment
• Recent (within 30 days of index procedure) or planned (within 60 days post-procedure) cardiac or major non-cardiac interventional or surgical procedure
• Recent (within 30 days of index procedure) stroke or transient ischemic attack
• Recent (within 30 days of index procedure) myocardial infarction
• Vascular access precluding delivery of implant with catheter-based system
• Severe heart failure (New York Heart Association Class IV)
• Prior cardiac transplant, history of mitral valve replacement or transcatheter mitral valve intervention, or any prosthetic mechanical valve implant
• Renal insufficiency, defined as estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73 m2 (by the Modification of Diet in Renal Disease equation)
• Platelet count \<75,000 cells/mm3 or \>700,000 cells/mm3, or white blood cell count \<3,000 cells/mm3
• Known allergy, hypersensitivity or contraindication to aspirin, heparin, or device materials (e.g., nickel, titanium) that would preclude any P2Y12 inhibitor therapy, or the patient has contrast sensitivity that cannot be adequately pre-medicated
• Actively enrolled or plans to enroll in a concurrent clinical study in which the active treatment arm may confound the results of this trial
• Unable to undergo general anesthesia
• Known other medical illness or known history of substance abuse that may cause non-compliance with the protocol or protocol-specified medication regimen, confound the data interpretation, or is associated with a life expectancy of less than 5 years
• A condition which precludes adequate transesophageal echocardiographic assessment Echo exclusion criteria:
• Left atrial appendage anatomy which cannot accommodate a commercially available control device or the CLAAS Implant per manufacturer IFU (e.g., the anatomy and sizing must be appropriate for both the investigational (CLAAS) and a commercially available device in order to be enrolled in the trial)
• Intracardiac thrombus or dense spontaneous echo contrast consistent with thrombus, as visualized by TEE prior to implant
• Left ventricular ejection fraction (LVEF) \<30%
• Moderate or large pericardial effusion \>10 mm or symptomatic pericardial effusion, signs or symptoms of acute or chronic pericarditis, or evidence of tamponade physiology
• Atrial septal defect that warrants closure
• High risk patent foramen ovale (PFO), defined as an atrial septal aneurysm (excursion \>15 mm or length \> 15 mm) or large shunt (early \[within 3 beats\] and/or substantial passage of bubbles, e.g., \>20)
• Moderate or severe mitral valve stenosis (mitral valve area \<1.5 cm2)
• Complex atheroma with mobile plaque of the descending aorta and/or aortic arch
• Evidence of cardiac tumor
DEVICE: CLAAS, DEVICE: WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder
Atrial Fibrillation, Stroke
I'm interested
Share via email
Show 70 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| AKFA Medline Olmazor, Tashkent | |
| Abrazo Arizona Heart Hospital Phoenix, Arizona | |
| AdventHealth Orlando Orlando, Florida | Chantie Garvey - (chantie.garvey@adventhealth.com) |
| AdventHealth Tampa Tampa, Florida | Daniel Robledo - (daniel.robledo@adventhealth.com) |
| Albany Medical Center / Capital Cardiology Associates Albany, New York | Mara Zink - (mzink@capitalcardiology.com) |
| Ascension St. Vincent - Carmel, IN Indianapolis, Indiana | |
| Ascension St. Vincent's Jacksonville Jacksonville, Florida | |
| Baptist Hospital of Miami Miami, Florida | Maria Ardid - (mariaar@baptisthealth.net) |
| Baystate Medical Center Springfield, Massachusetts | Christine Callahan - (Christine.Callahan@baystatehealth.org) |
| CHI Health / CommonSpirit Research Institute Omaha, Nebraska | Maddie Esch - (maddie.esch@commonspirit.org) |
| CHRISTUS Health Tyler, Texas | Jamie-Crystal Wylie - (jamiecrystal.wylie@christushealth.org) |
| Carilion Clinic Roanoke, Virginia | Brittny O'Toole - (bmotoole@carilionclinic.org) |
| Catholic Medical Center Manchester, New Hampshire | |
| Centracare Heart and Vascular Center Saint Cloud, Minnesota | Audrey Hillebrand-Raap - (Audrey.Hillenbrand-Raap@centracare.com) |
| Chapidze Heart Disease Center Tbilisi, | Teona Gamezardashvili - (t.gamezardashvili@clinicalaccelerator.com) Beka Khakhutashvili - (b.khakhutashvili@clinicalaccelerator.com) |
| Chippenham Hospital Richmond, Virginia | Ariana Dickens - (Ariana.Dickens@hcahealthcare.com) |
| Community Memorial Hospital Ventura Ventura, California | Melissa Grant - (melissa@siteresearchmgmt.com) |
| Cooper University - Heart House Haddon Heights, New Jersey | Kaitlyn Downey - (KDowney@hearthousenj.com) |
| Corewell Health Grand Rapids, Michigan | |
| Emory University Atlanta, Georgia | Teressa Burns - (teressa.burns@emory.edu) |
| Erlanger Health System Chattanooga, Tennessee | Kumari Kasa - (Parvathikumari.Kasa@erlanger.org) |
| Grandview Medical Center Birmingham, Alabama | Kristy Raco - (kristy.raco@grandviewhealth.com) |
| Hackensack University Medical Center Hackensack, New Jersey | Tarah Martelly - (tarah.martelly@hmhn.org) |
| Henry Ford Providence Southfield Hospital Southfield, Michigan | |
| Henry Ford St. John Hospital Detroit, Michigan | Renee Bess - (rbess1@hfhs.org) |
| HonorHealth Scottsdale, Arizona | Kiersten Rundio - (krundio@honorhealth.com) |
| Houston Methodist Houston, Texas | Chinwe Ngumezi - (ccngumezi@houstonmethodist.org) |
| Huntington Hospital Huntington, New York | Samia Solh - (Samia.Solh@huntingtonhealth.org) |
| Hôpital Privé Jacques Cartier Massy, | Séverine Roger - (s.roger@icps.com.fr) |
| Israeli-Georgian Medical Research Clinic Helsicore Tbilisi, | Natalia Cornea - (n.cornea@clinicalaccelerator.com) Teona Gamazerdashvili - (t.gamezardashvili@clinicalaccelerator.com) |
| Kansas City Cardiac Arrhythmia Research, LLC Overland Park, Missouri | Rachael Koeppe - (rachael.koeppe@hcahealthcare.com) |
| Lahey Hospital & Medical Centeer Burlington, Massachusetts | Jean Byrne - (jean.byrne@lahey.org) |
| Lankenau Heart Institute Wynnewood, Pennsylvania | Rachael Cohen - (cohenrac@mlhs.org) |
| Largo Medical Center Upper Marlboro, Maryland | Holly Lynn Grospitch - (HollyLynn.Grospitch@hcahealthcare.com) |
| Legacy Emanuel Hospital and Health Portland, Oregon | Karla Kummer - (kkummer@lhs.org) |
| Lifespan Health System Providence, Rhode Island | |
| M Health Fairview St. John's Hospital Maplewood, Minnesota | Beth Jorgenson - (beth.jorgenson@fairview.org) |
| MedStar Union Memorial Hospital Baltimore, Maryland | Keith Moyer - (Keith.T.Moyer@medstar.net) |
| Medstar Washington Hospital Center Washington D.C., District of Columbia | |
| Memorial Hermann Memorial City Medical Center Houston, Texas | Maddie Peek - (maddie@whactc.com) |
| Midwest Cardiovascular Institute Naperville, Illinois | Sherri McCoy - (Sherri.McCoy@cardio.com) |
| Mission Hospital Asheville, North Carolina | Christina Riggsbee - (christina.riggsbee@hcahealthcare.com) |
| Mount Sinai Hospital New York, New York | Joshua Wiener - (joshua.wiener@mountsinai.org) |
| North Mississippi Medical Center Tupelo, Mississippi | Kristin Eads - (KEads@nmhs.net) |
| Northside Hospital, Inc Atlanta, Georgia | Katie Moore - (katie.moore@northside.com) |
| Ohio Health Research Institute Columbus, Ohio | |
| Pacific Heart Institute Santa Monica, California | Stacy Chang - (research@pacificheart.com) |
| Piedmont Health Institute Atlanta, Georgia | Caryn Bernstein - (caryn.bernstein@piedmont.org) |
| Pima Heart & Vascular Tucson, Arizona | |
| Promedica Toledo Hospital Toledo, Ohio | Sonya Inderrieden - (Sonya.Inderrieden@ProMedica.org) |
| Republican Specialized Center for Surgery named after V. Vakhidov Chilanzar, Tashkent | |
| Saint Luke's Hospital of Kansas City Kansas City, Missouri | Cheryl Rutherford - (cjrutherford@saint-lukes.org) |
| Sarasota Memorial Health Care System Sarasota, Florida | Kristen Sangmaster - (kristen-sangmaster@smh.com) |
| Senatra Norfolk Norfolk, Virginia | Linette Klevan - (LRKLEVAN@sentara.com) |
| St. Bernard's Medical Center Jonesboro, Arkansas | Kayla Rubino - (krubino@dnairresearch.com) |
| Tbilisi Heart Center Tbilisi, | Ketevan Gabunia, MD - (kgabunia@tbhc.ge) |
| Tbilisi Heart and Vascular Clinic Tbilisi, | Natalia Cornea - (n.cornea@clinicalaccelerator.com) Teona Gamezardashvili - (t.gamezardashvili@clinicalaccelerator.com) |
| Tennova Healthcare - Turkey Creek Medical Center Knoxville, Tennessee | Juliana Bailey - (juliana.bailey@tennova.com) |
| Terrebone - Cardiovascular Institute of the South Houma, Louisiana | Jennifer Aucoin - (jennifer.aucoin@cardio.com) |
| TriHealth Cincinnati, Ohio | Marta McClellan - (Marta_McClellan@trihealth.com) |
| Trident Medical Center Charleston, South Carolina | Molly Harper - (Molly.Harper@hcahealthcare.com) |
| UPMC Harrisburg Mechanicsburg, Pennsylvania | Matthew Rutt - (ruttmd4@upmc.edu) |
| USF - Tampa General Hospital Tampa, Florida | Jacky He - (jackyhe@usf.edu) |
| University of Buffalo / Kaleida Health Buffalo, New York | Cassandra Davern - (cadavern@buffalo.edu) |
| University of Iowa Iowa City, Iowa | Trisha Elliott - (trisha-elliott@uiowa.edu) |
| University of Kansas Medical Center Kansas City, Kansas | Grace Millington - (gmillington@kumc.edu) |
| Vanderbilt University Medical Center Nashville, Tennessee | Amanda Caroll - (Amanda.carroll@vumc.org) |
| Virginia Commonwealth University Richmond, Virginia | Esoterica Berry - (Esoterica.Berry@vcuhealth.org) |
| Wellstar Kennestone Hospital Marietta, Georgia | Jennifer Cuvo - (Jennifer.Cuvo@wellstar.org) |
| West Virginia University Morgantown, West Virginia | Marvin Hudson - (marvin.hudson1@wvumedicine.org) |
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pociredir
Call Center - clinicaltrials@fulcrumtx.com
NCT05169580
Show full eligibility criteria
Hide eligibility criteria
Key
• ≥4 to 10 episodes of SCD pain crisis over 12 months, or ≥2 to 5 over 6 months prior to screening
• ≥2 episodes of SCD pain crisis plus at least one of the following over previous 12 months: i) Acute chest syndrome (ACS) ii. Hepatic or splenic sequestration iii. Priapism
• ≥2 of the following events over the previous 12 months:i. ACS ii. Hepatic or splenic sequestration iii. Priapism
• Tricuspid regurgitant jet velocity (TRV) ≥ 3.0 meter/second(m/s) OR TRV ≥ 2.5 m/s + N-terminal pro b-type natriuretic peptide (NT-proBNP) plasma level ≥ 160 picogram per milliliter; OR documented ongoing pulmonary hypertension diagnosed from previous echocardiogram or right-sided heart catheterization with mean pulmonary artery pressure \> 25 millimeter of mercury;
• SCD-related chronic kidney disease (CKD)
• Meet medical criteria to receive (e.g., post-cerebrovascular accident) but are contraindicated for chronic transfusions (e.g., alloimmunization, transfusion reactions) * Previous experience with Hydroxyurea (HU) but have shown to be unresponsive and/or intolerant or ineligible AND * Previous experience with a stable dose of voxelotor, crizanlizumab, and/ or L-glutamine but have shown to be unresponsive and/or intolerant or ineligible * Per Investigator's recommendation, participants may continue crizanlizumab and/or L-glutamine but must be on a stable dose for at least 6 months * HbF ≤ 20% of total Hb * Total Hb ≥ 5.5 g/dL and ≤ 12 g/dl (males) or ≤ 10.6 g/dl (females) at screening. * Participant must meet both of the following laboratory values at screening:
• Absolute neutrophil count ≥ 1.5 × 10\^9 per liter (/l)
• Platelets ≥ 80 × 10\^9/l
• Absolute reticulocyte count at screening ≥ 100 x 10\^9/l. Key
Inclusion Criteria:
* Participant is 18 to 65 years of age, inclusive at the time informed consent is obtained.
* Documented SCD at the time of screening (S/S, S/β0, S/β+, and S/C only) as confirmed through review of medical records or HPLC.
* Participants who meet at least one the following criteria:
• ≥4 to 10 episodes of SCD pain crisis over 12 months, or ≥2 to 5 over 6 months prior to screening
• ≥2 episodes of SCD pain crisis plus at least one of the following over previous 12 months: i) Acute chest syndrome (ACS) ii. Hepatic or splenic sequestration iii. Priapism
• ≥2 of the following events over the previous 12 months:i. ACS ii. Hepatic or splenic sequestration iii. Priapism
• Tricuspid regurgitant jet velocity (TRV) ≥ 3.0 meter/second(m/s) OR TRV ≥ 2.5 m/s + N-terminal pro b-type natriuretic peptide (NT-proBNP) plasma level ≥ 160 picogram per milliliter; OR documented ongoing pulmonary hypertension diagnosed from previous echocardiogram or right-sided heart catheterization with mean pulmonary artery pressure \> 25 millimeter of mercury;
• SCD-related chronic kidney disease (CKD)
• Meet medical criteria to receive (e.g., post-cerebrovascular accident) but are contraindicated for chronic transfusions (e.g., alloimmunization, transfusion reactions) * Previous experience with Hydroxyurea (HU) but have shown to be unresponsive and/or intolerant or ineligible AND * Previous experience with a stable dose of voxelotor, crizanlizumab, and/ or L-glutamine but have shown to be unresponsive and/or intolerant or ineligible * Per Investigator's recommendation, participants may continue crizanlizumab and/or L-glutamine but must be on a stable dose for at least 6 months * HbF ≤ 20% of total Hb * Total Hb ≥ 5.5 g/dL and ≤ 12 g/dl (males) or ≤ 10.6 g/dl (females) at screening. * Participant must meet both of the following laboratory values at screening:
• Absolute neutrophil count ≥ 1.5 × 10\^9 per liter (/l)
• Platelets ≥ 80 × 10\^9/l
• Absolute reticulocyte count at screening ≥ 100 x 10\^9/l. Key
Exclusion Criteria:
* Sickle cell complication requiring care from a medical provider in hospital or emergency care setting in the 14 days prior to starting study drug.
* History of bone marrow transplant or human stem cell transplant or gene therapies.
* • Participants with a history of severe renal disease defined as estimated glomerular filtration rate \< 30 mL/min/1.73m\^2. Participants on dialysis of any kind are excluded.
* Participants receiving regularly scheduled transfusions or therapeutic phlebotomies, or any participant who has been transfused within 60 days prior to initiating study drug.
* Participant with active malignancy, or history of cancer (except for squamous cell skin cancer, basal cell skin cancer, and stage 0 cervical carcinoma in situ, with no recurrence for the last 5 years), or has an immediate family member with known or suspected familial cancer syndrome. Known presence of a chromosomal abnormality or genetic mutation that may put the participant at an increased risk of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).
* Participant currently on HU, or have received HU, within 60 days prior to initiating study drug. DRUG: Pociredir oral capsule(s)
Sickle Cell Disease, Sickle Cell Anemia
Sickle Cell Disease, Sickle Cell Anemia, Pharmacokinetics, Pharmacodynamics, Pociredir, Open label
I'm interested
Share via email
Show 25 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Atlanta Center for Medical Research Atlanta, Georgia | |
| Augusta University Augusta, Georgia | |
| Axon Clinical Research Institute Baltimore, Maryland | |
| Barau Dikko Teaching Hospital Kaduna, | |
| Boston Medical Center Boston, Massachusetts | |
| Charlotte Maxeke Johannesburg Academic Hospital Johannesburg, | |
| Eastern Carolina University Greenville, North Carolina | |
| Foundation for Sickle Cell Disease Research, LLC Hollywood, Florida | |
| Inova Schar Cancer Institute Fairfax, Virginia | |
| Jacobi Medical Center The Bronx, New York | |
| Lynn Health Science Institute Oklahoma City, Oklahoma | |
| Mississippi Center for Advanced Medicine Madison, Mississippi | |
| National Hospital, Abuja Abuja, | |
| Our Lady of the Lake Hospital Baton Rouge, Louisiana | |
| Queens Hospital Cancer Center Jamaica, New York | |
| Sonar Research Center Atlanta, Georgia | |
| University of Arkansas for Medical Sciences (UAMS) Little Rock, Arkansas | |
| University of California, Los Angeles Los Angeles, California | |
| University of Ibadan Ibadan, | |
| University of Illinois Chicago Chicago, Illinois | |
| University of Miami Health System Miami, Florida | |
| University of North Carolina at Chapel Hill Chapel Hill, North Carolina | |
| University of Texas Houston Houston, Texas | |
| Virginia Commonwealth University Richmond, Virginia | |
| Visionaries Clinical Research Atlanta, Georgia |
Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)
ctrrecruit@vcu.edu
NCT06577441
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* GENERAL MYLEOMATCH REGISTRATION CRITERIA:
* Patients must be registered to the Master Screening and Reassessment Protocol (MSRP) and assigned to this protocol by the MATCHBox Treatment Verification Team.
* Participants must not have received prior anti-cancer therapy for AML or MDS.
* Note: Hydroxyurea to control the white blood cell count (WBC) is allowed.
* Note: Prior erythroid stimulating agent (ESA) is not considered prior therapy for the purposes of eligibility.
* Participants must not be currently receiving any cytarabine-containing therapy other than up to 1 g/m\^2 of cytarabine, which is allowed for urgent cytoreduction. The use of prior hydroxyurea, all-trans retinoic acid (ATRA), BCR-ABL directed tyrosine kinase inhibitor, erythropoiesis-stimulating agent, thrombopoietin receptor agonist and lenalidomide is allowed
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients must have a morphologically-confirmed diagnosis of MDS with a Revised International Prognostic Scoring System (IPSS-R) score ≥ 4.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients must have a detectable pathogenic IDH2 mutation based on the National Cancer Institute (NCI) Myeloid Panel.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): No prior treatment with deoxyribonucleic acid (DNA) methyltransferase inhibitors (ASTX727, azacitidine, or decitabine).
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Prior treatment with growth factors (ESA, granulocyte colony-stimulating factor \[g-CSF\], thrombopoietin \[TPO\] agonist), lenalidomide or luspatercept is allowed with a maximum limit of 1 month of exposure.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients with therapy-related MDS are allowed.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Age ≥ 18 years.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Total bilirubin ≤ 1.5 x upper limit of normal (ULN)
* Unless elevated due to Gilbert's syndrome. In patients with Gilbert's syndrome, if the total bilirubin is ≤ 3.0 x ULN, then they are eligible for enrollment.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamic-pyruvic transaminase \[SGPT\]) ≤ 3.0 x upper limit of normal (ULN).
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Creatinine clearance ≥ 30 mL/min
* To be calculated using Cockroft Gault formula.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Not pregnant and not nursing, because this study involves: an agent that has known genotoxic, mutagenic and teratogenic effects.
* Therefore, for women of childbearing potential only, a negative pregnancy test done as part of screening lab work prior to registration is required.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible for this trial.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated.
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load.
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): Patients on the ASTX727 monotherapy arm (Regimen 1) that do not achieve a CR (complete response), CRL (CR with limited count recovery), or CRh (CR with partial count recovery) after completing 6 cycles of study treatment.
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): ECOG performance status ≤ 2.
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): Total bilirubin ≤ 1.5 x upper limit of normal (ULN).
* Unless elevated due to Gilbert's syndrome. In patients with Gilbert's syndrome if the total bilirubin is ≤ 3.0 x ULN, then they are eligible for enrollment.
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): AST (SGOT)/ALT (SGPT) ≤ 3.0 x upper limit of normal (ULN)
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): Creatinine clearance ≥ 30 mL/min
* To be calculated using Cockroft Gault formula.
* RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): Not pregnant and not nursing, because this study involves: an agent that has known genotoxic, mutagenic and teratogenic effects. PROCEDURE: Biospecimen Collection, PROCEDURE: Bone Marrow Aspiration, PROCEDURE: Bone Marrow Biopsy, DRUG: Decitabine and Cedazuridine, DRUG: Enasidenib
Myelodysplastic Syndrome
I'm interested
Share via email
Show 109 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Alta Bates Summit Medical Center-Herrick Campus Berkeley, California | Site Public Contact - (clinicalresearch@sutterhealth.org) |
| BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri | |
| Benefis Sletten Cancer Institute Great Falls, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Billings Clinic Cancer Center Billings, Montana | Site Public Contact - (research@billingsclinic.org) |
| Cancer Care Center of O'Fallon O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Care Specialists of Illinois - Decatur Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Hematology Centers - Flint Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Carle Cancer Center Urbana, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | Site Public Contact - (Research@carle.com) |
| Carle at The Riverfront Danville, Illinois | Site Public Contact - (Research@Carle.com) |
| Centro Comprensivo de Cancer de UPR San Juan, | Site Public Contact - (ctsucontact@westat.com) |
| Community Hospital of Anaconda Anaconda, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Community Medical Center Missoula, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Crossroads Cancer Center Effingham, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Decatur Memorial Hospital Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Duke University Medical Center Durham, North Carolina | |
| Duluth Clinic Ashland Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Deer River Clinic Deer River, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center-South University Clinic Fargo, North Dakota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Hibbing Clinic Hibbing, Minnesota | |
| Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Sandstone Sandstone, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Virginia Clinic Virginia, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Geisinger Medical Center Danville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Genesee Hematology Oncology PC Flint, Michigan | |
| Genesys Hurley Cancer Institute Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Gundersen Lutheran Medical Center La Crosse, Wisconsin | Site Public Contact - (cancerctr@gundersenhealth.org) |
| HSHS Saint Elizabeth's Hospital O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Hennepin County Medical Center Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Huntsman Cancer Institute/University of Utah Salt Lake City, Utah | Site Public Contact - (cancerinfo@hci.utah.edu) |
| Illinois CancerCare - Washington Washington, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Bloomington Bloomington, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Canton Canton, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Carthage Carthage, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Dixon Dixon, Illinois | |
| Illinois CancerCare-Eureka Eureka, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Galesburg Galesburg, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Kewanee Clinic Kewanee, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Macomb Macomb, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Ottawa Clinic Ottawa, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Pekin Pekin, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peoria Peoria, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peru Peru, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Princeton Princeton, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| LSU Health Baton Rouge-North Clinic Baton Rouge, Louisiana | Site Public Contact - (research@ololrmc.com) |
| Logan Health Medical Center Kalispell, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Loyola University Medical Center Maywood, Illinois | |
| Medical College of Wisconsin Milwaukee, Wisconsin | |
| Mercy Medical Center - Des Moines Des Moines, Iowa | Site Public Contact - (cancerresearch@mercydesmoines.org) |
| Mills Health Center San Mateo, California | Site Public Contact - (clinicalresearch@sutterhealth.org) |
| Missouri Baptist Medical Center St Louis, Missouri | |
| Missouri Baptist Sullivan Hospital Sullivan, Missouri | |
| Northwestern Medicine Cancer Center Delnor Geneva, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Cancer Center Kishwaukee DeKalb, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Glenview Outpatient Center Glenview, Illinois | |
| Northwestern Medicine Grayslake Outpatient Center Grayslake, Illinois | |
| Northwestern Medicine Lake Forest Hospital Lake Forest, Illinois | Site Public Contact - (cancertrials@northwestern.edu) |
| Northwestern Medicine Orland Park Orland Park, Illinois | Site Public Contact - (nctnprogram_rhlccc@northwestern.edu) |
| Northwestern University Chicago, Illinois | Site Public Contact - (cancer@northwestern.edu) |
| Ohio State University Comprehensive Cancer Center Columbus, Ohio | Site Public Contact - (Jamesline@osumc.edu) |
| Our Lady of The Lake Baton Rouge, Louisiana | |
| Our Lady of the Lake Physician Group Baton Rouge, Louisiana | Site Public Contact - (research@ololrmc.com) |
| Parkland Health Center - Farmington Farmington, Missouri | |
| Phoebe Putney Memorial Hospital Albany, Georgia | Site Public Contact - (ga_cares@augusta.edu) |
| Prisma Health Cancer Institute - Butternut Greenville, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Easley Easley, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Eastside Greenville, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Faris Greenville, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Greer Greer, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Seneca Seneca, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Roswell Park Cancer Institute Buffalo, New York | Site Public Contact - (askroswell@roswellpark.org) |
| Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey | |
| Saint Luke's Cancer Institute - Boise Boise, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Fruitland Fruitland, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Meridian Meridian, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Nampa Nampa, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin | Site Public Contact - (WI_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri | |
| San Juan City Hospital San Juan, | |
| Southern Illinois University School of Medicine Springfield, Illinois | |
| Springfield Clinic Springfield, Illinois | |
| Springfield Memorial Hospital Springfield, Illinois | Site Public Contact - (pallante.beth@mhsil.com) |
| Swedish Cancer Institute-Edmonds Edmonds, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Swedish Cancer Institute-Issaquah Issaquah, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Swedish Medical Center-First Hill Seattle, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| The James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky | |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology - Canton Canton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Tufts Medical Center Boston, Massachusetts | Site Public Contact - (ContactUsCancerCenter@TuftsMedicalCenter.org) |
| UC Comprehensive Cancer Center at Silver Cross New Lenox, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| UChicago Medicine Northwest Indiana Crown Point, Indiana | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| University of Chicago Comprehensive Cancer Center Chicago, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| University of Chicago Medicine-Orland Park Orland Park, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| University of New Mexico Cancer Center Albuquerque, New Mexico | Site Public Contact - (HSC-ClinicalTrialInfo@salud.unm.edu) |
| University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma | Site Public Contact - (ou-clinical-trials@ouhsc.edu) |
| University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania | |
| UofL Health Medical Center Northeast Louisville, Kentucky | Site Public Contact - (ctoinfo@louisville.edu) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| William S Middleton VA Medical Center Madison, Wisconsin |
High-Dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients
Brooke Burgess, MS - URCC_22053@urmc.rochester.edu
NCT05838716
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Be diagnosed with Stage I-IV prostate cancer without metastases to bone (lymph node involvement and prior diagnosis of a primary cancer is allowed)
* Be age 60 years or older
* Be starting ADT or have received their first ADT treatment in the past 3 months, with a total of at least 6 planned months of treatment (both luteinizing hormone-releasing hormone \[LHRH\] antagonists and LHRH agonists are permitted)
* Have a total serum vitamin D between 10 and 27 ng/ml
* Have a total serum calcium of less than or equal to 10.5 mg/dl
* Have a normal GFR (glomerular filtration rate \> 30ml)
* Agree not to take calcium and/or vitamin D supplements for the duration of the intervention other than those provided by the study
* Be able to provide written informed consent
* Be able to swallow pills and capsules
* Be able to speak and read English
Exclusion Criteria:
* Have long term (greater than 3 months) use of any pharmacologic bone-modifying agent including but not limited to oral or intravenous (IV) bisphosphonates, denosumab, or teriparatide prior to enrollment
* Have a diagnosis of stage IV chronic kidney disease
* Have a diagnosis of grade II or greater hypercalcemia (serum calcium greater than 11.5 mg/dl)
* Have a history of hypercalcemia or vitamin D toxicity/sensitivity PROCEDURE: Biospecimen Collection, DIETARY_SUPPLEMENT: D Vitamin, PROCEDURE: Dual X-ray Absorptiometry, DRUG: Placebo Administration, OTHER: Quality-of-Life Assessment, OTHER: Questionnaire Administration
Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
I'm interested
Share via email
Show 46 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Ballad Health Cancer Care - Bristol Bristol, Virginia | Site Public Contact - (charles.mays@balladhealth.org) |
| Ballad Health Cancer Care - Kingsport Kingsport, Tennessee | Site Public Contact - (charles.mays@balladhealth.org) |
| Bon Secours Cancer Institute at Reynolds Crossing Richmond, Virginia | Site Public Contact - (Anne_caramella@bshsi.org) |
| Bon Secours Memorial Regional Medical Center Mechanicsville, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Saint Francis Medical Center Midlothian, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Saint Mary's Hospital Richmond, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Cancer Care Center of O'Fallon O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Care Specialists of Illinois - Decatur Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Carilion Roanoke Memorial Hospital Roanoke, Virginia | |
| Carle Cancer Center Urbana, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Effingham Effingham, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | Site Public Contact - (Research@carle.com) |
| Carle at The Riverfront Danville, Illinois | Site Public Contact - (Research@Carle.com) |
| CarolinaEast Medical Center New Bern, North Carolina | Site Public Contact - (lharrison@carolinaeasthealth.com) |
| Community Medical Center Missoula, Montana | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Gibbs Cancer Center-Gaffney Gaffney, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Gibbs Cancer Center-Pelham Greer, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Helen F Graham Cancer Center Newark, Delaware | Site Public Contact - (lbarone@christianacare.org) |
| Louisiana State University Health Science Center New Orleans, Louisiana | Site Public Contact - (emede1@lsuhsc.edu) |
| Medical Oncology Hematology Consultants PA Newark, Delaware | Site Public Contact - (lbarone@christianacare.org) |
| Mercy Hospital Coon Rapids, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mercy Hospital Saint Louis St Louis, Missouri | |
| Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Nash UNC HealthCare Rocky Mount, North Carolina | |
| Ochsner Medical Center Jefferson New Orleans, Louisiana | Site Public Contact - (Elisemarie.curry@ochsner.org) |
| OptumCare Cancer Care at Charleston Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Regional Cancer Center at Johnson City Medical Center Johnson City, Tennessee | Site Public Contact - (charles.mays@balladhealth.org) |
| Regions Hospital Saint Paul, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| SMC Center for Hematology Oncology Union Union, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Saint Francis Cancer Center Greenville, South Carolina | Site Public Contact - (melissa_beckman@bshsi.org) |
| Saint Francis Hospital Federal Way, Washington | Site Public Contact - (melissa_beckman@bshsi.org) |
| Saint John's Hospital - Healtheast Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin | Site Public Contact - (WI_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Spartanburg Medical Center Spartanburg, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| University Medical Center New Orleans New Orleans, Louisiana | Site Public Contact - (emede1@lsuhsc.edu) |
| University of Kansas Cancer Center Kansas City, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center - Lee's Summit Lee's Summit, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center - North Kansas City, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center-Overland Park Overland Park, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| VCU Massey Cancer Center at Stony Point Richmond, Virginia | Site Public Contact - (ctoclinops@vcu.edu) |
| Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
A Virtual Reality Brief Violence Intervention: Preventing Gun Violence Among Violently Injured Adults
Nicholas Thomson - Nicholas.thomson@vcuhealth.org
NCT06239285
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* violently injured patients from VCU's Level 1 Trauma Center
* 18 years or older
* English-speaking
Exclusion Criteria:
* Under 18 years old
* Not a victim of Violent crime DEVICE: Brief Violence Intervention VR (BVI-VR), OTHER: Treatment as Usual (TAU)
Violence
Firearm Violence Victim
I'm interested
Share via email
Show 1 location
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Virginia Commonwealth University Richmond, Virginia | Nicholas Thomson - (nicholas.thomson@vcuhealth.org) |
A Study to Learn More About How Well Sevabertinib (BAY 2927088) Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2) (SOHO-02)
Bayer Clinical Trials Contact - clinical-trials-contact@bayer.com
NCT06452277
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Participant must be ≥18 years of age or over the legal age of consent in countries where that is greater than 18 years at the time of signing the informed consent.
* Documented histologically or cytologically confirmed locally advanced non-squamous NSCLC, not suitable for definitive therapy or metastatic non-squamous NSCLC at screening (small cell or mixed histologies are excluded) (Stage III-IV NSCLC).
* Documented activating HER2 mutation in the tyrosine kinase domain (TKD) assessed by tissue molecular test in a CLIA-certified (US sites) or an equally accredited (outside of the US) local laboratory. However, participants may be included at the discretion of the investigator if the laboratory performing the assay is not CLIA or similar certified but the laboratory is locally accredited.
* No prior systemic therapy for locally advanced or metastatic disease. No prior treatment with a HER2 ex20ins-targeted therapy (e.g. poziotinib, trastuzumab deruxtecan). Participants who received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant therapy was completed at least 12 months prior to the start of screening.
* Eligible to receive treatment with the selected platinum-based doublet-chemotherapy (i.e. cisplatin/pemetrexed or carboplatin/pemetrexed) and pembrolizumab in accordance with the SmPC/Product Information.
Exclusion Criteria:
* Known history of prior malignancy except if the participant has undergone potentially curative therapy with no evidence of that disease recurrence for five years since initiation of that therapy. Exception: the following cancer types are acceptable within five years if curatively treated or under surveillance:
* a. in situ cancers of cervix, breast, or skin,
* b. superficial bladder cancer (Ta, Tis and T1),
* c. limited-stage prostate cancer,
* d. basal or squamous cancers of the skin.
* Tumors with targetable alterations with approved available therapy, with the exception of HER2 mutation in the TKD.
* Inability to discontinue treatment with chronic systemic corticosteroids. Participants who require intermittent use of bronchodilators, inhaled steroids, or local steroid injections would not be excluded from the study. Replacement therapy (e.g., physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is acceptable, provided that the dose is stable for \>4 weeks prior to planned start of study intervention.
* Pre-existing peripheral neuropathy that is Grade ≥2 by CTCAE (v5.0).
* History of severe hypersensitivity reaction to treatment with a monoclonal antibody.
* Prior radiotherapy outside of the brain within 21 days before of planned start of study intervention. Participants must have recovered from all radiation-related toxicities and not require corticosteroids. DRUG: BAY2927088, DRUG: Pembrolizumab, DRUG: Cisplatin, DRUG: Carboplatin, DRUG: Pemetrexed
Advanced Non-small Cell Lung Cancer, HER2 Mutation
NSCLC, ERBB2 mutation
I'm interested
Share via email
Show 279 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| ?enry Durant Hospital Center-4th Oncology Department and Clinical Trials Unit Athens, | |
| A Beneficencia Portuguesa de Sao Paulo - Hospital BP Mirante São Paulo, | |
| AORN San Giuseppe Moscati Avellino - U.O.C. Oncologia Medica Avellino, Campania | |
| ASST Sette Laghi_Ospedale Macchi - Oncologia Varese, | |
| AZ Delta | Clinical Trial Center - Pneumology Roeselare, West-Flanders | |
| Aalborg University hospital - oncology department Aalborg, | |
| Aarhus Universitetshospital Aarhus, | |
| Adana Sehir Egitim ve Arastirma Hastanesi Yüreğir, | |
| AdventHealth Cancer Institute Orlando, Florida | |
| Allegheny General Hospital Pittsburgh, Pennsylvania | |
| Ankara Bilkent Sehir Hastanesi Ankara, | |
| Ankara Etlik Sehir Hastanesi Yenimahalle, Ankara | |
| Antwerp University Hospital | Oncology Department Antwerp, | |
| Assuta Ashdod Public Hospital (R.A) Ashdod, | |
| Austin Hospital - Olivia Newton John Cancer Research Institute Heidelberg, Victoria | |
| Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Oncologia Medica Palermo, | |
| Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - UOC Oncologia Medica Bologna, Emilia-Romagna | |
| Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica Orbassano, Piedmont | |
| BC Cancer - Vancouver Site Vancouver, British Columbia | |
| Beacon Hospital Petaling Jaya, | |
| Beijing Cancer Hospital - Oncology Department Beijing, Beijing Municipality | |
| Beijing Chest Hospital, Capital Medical University Beijing, | |
| Beijing Hospital Beijing, Beijing Municipality | |
| Belfast City Hospital Belfast, | |
| Bioclinic Thessaloniki Thessaloniki, | |
| Blacktown Cancer & Haematology Centre Blacktown, New South Wales | |
| Brampton Civic Hospital - Oncology Brampton, Ontario | |
| Budapesti Uzsoki Utcai Korhaz - Tüdogyógyászati Osztály Budapest, | |
| CHU Montpellier - Hopital Arnaud de Villeneuve - Service oncologie thoracique Montpellier, | |
| CHU de Rouen - Hopital Charles Nicolle - Service de Pneumologie Rouen, | |
| CHULN - Hospital Pulido Valente Lisbon, | |
| Calvary Mater Hospital Newcastle Waratah, New South Wales | |
| Cancer Hospital, Chinese Academy of Medical Sciences Beijing, | |
| CardioMed S.R.L. Cluj-Napoca, | |
| Careggi University Hospital - Oncologia Clinica Florence, | |
| Careggi University Hospital - Oncologia Clinica Florence, | |
| Centre Antoine Lacassagne - Departement Oncologie Nice, | |
| Centre Hospitalier Intercommunal Creteil - Service de pneumologie Créteil, | |
| Centre Hospitalier Michallon Grenoble - Service pneumologie La Tronche, | |
| Centre Hospitalier Universitaire de Limoges - unite oncologie thoracique Limoges, | |
| Centro Médico Privado CEMAIC Córdoba, | |
| Centro Paulista de Oncologia (CPO) - Sao Paulo - Faria Lima São Paulo, | |
| Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia Verona, | |
| Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC) Buenos Aires, | |
| Centro de Investigaciones Clínicas, Clínica Viedma Viedma, | |
| Centro de Pesquisa da Clínica de Oncologia Reichow Blumenau, Santa Catarina | |
| Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati Aviano, Friuli Venezia Giulia | |
| Centrul de Oncologie Sfantul Nectarie Craiova, | |
| Charité Universitätsmedizin Berlin CBF - Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie Berlin, | |
| Chi-Mei Medical Center, Liouyine Tainan City, | |
| Chonnam National University Hwasun Hospital Hwasun-gun, | |
| Chung Shan Medical University Hospital Taichung, | |
| Chungbuk National University Hospital Chungju, | |
| Ciutat Sanitària i Universitaria de la Vall d'Hebron Barcelona, | |
| Clinica Integral Internacional de Oncologia S. de R.L. de C.V. Puebla City, | |
| Columbia Asia Hospital Bukit Rimau Shah Alam, Selangor | |
| Complejo Hospitalario Universitario A Coruña (CHUAC) A Coruña, | |
| Complex Oncology Center - Plovdiv EOOD Plovdiv, | |
| Concord Repatriation General Hospital - Medical Oncology Clinical Trials Unit Concord, New South Wales | |
| Curie Oncology | Farrer Singapore, | |
| Docrates Mehiläinen Syöpäsairaala Helsinki, Uusimaa | |
| Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii Wroclaw, | |
| Ege Universitesi Tip Fakultesi Izmir, | |
| Fakultna Nemocnica Trnava Trnava, | |
| Fakultní Nemocnice Olomouc - Klinika plicních nemocí a tuberkulózy Olomouc, | |
| Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1 Milan, Lombardy | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOSD Oncologia Toraco-Polmonare Rome, Lazio | |
| Fujian Cancer Hospital Fuzhou, Fujian | |
| Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica Lisbon, | |
| Fundacion Instituto Valenciano de Oncologia (IVO Valencia, | |
| Fundación CENIT para la Investigación en Neurociencias Ciudad Autonoma Buenos Aires, | |
| Fundação Pio XII - Hospital de Câncer de Barretos Barretos, São Paulo | |
| General Hospital of Athens "Alexandra''-Plasma Cell Dyscrasias,Department of Clinical Therapeutics,School of Medicine,NKUA Athens, | |
| Gleneagles Penang Medical Center George Town, | |
| Guangxi Medical University (GXMU) - Affiliated Tumor Hospital Nanning, | |
| Guangzhou Medical University - The First Affiliated Hospital Guangzhou, | |
| Gustave Roussy - Departement Oncologie-Radiotherapie Villejuif, | |
| Gyeongsang National University Hospital Jinju, Gyeongsangnam-do | |
| HFR Freiburg - Kantonsspital Fribourg, | |
| Harbin Medical University Cancer Hospital Harbin, Heilongjiang | |
| Hokkaido University Hospital Hokkaido, Sapporo, | |
| Hong Kong United Oncology Centre Kowloon, | |
| Hopital Foch - Oncologie digestive et thoracique Suresnes, | |
| Hopital La Cavale Blanche - CHU de Brest - institut de cancerologie et d'imagerie Brest, | |
| Hopital Nord Laennec - Oncologie medicale thoracique et digestive Nantes, | |
| Hospital Clinic de Barcelona (Hospital Clinic i Provincial) Barcelona, | |
| Hospital General Universitario Gregorio Marañón | Oncología Madrid, | |
| Hospital Pedro Hispano | Clinical Research Center Matosinhos Municipality, Porto District | |
| Hospital Quiron Dexeus - Oncologia Barcelona, | |
| Hospital Sirio Libanes São Paulo, | |
| Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia Brasília, | |
| Hospital Universitario De Navarra - Oncologia Pamplona, | |
| Hospital Universitario Fundacion Jimenez Diaz- Oncology Service Madrid, | |
| Hospital Universitario Puerta De Hierro De Majadahonda - Oncologia Majadahonda, Madrid | |
| Hospital Universitario Ramon Y Cajal - Oncologia Madrid, | |
| Hospital Universitario Y Politecnico La Fe - Oncologia Valencia, | |
| Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia Nuevo León, | |
| Hospital de Base | Funfarme - Centro Integrado de Pesquisa - Cardiologia São José do Rio Preto, São Paulo | |
| Hubei Cancer Hospital Wuhan, | |
| Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia Rozzano, Lombardy | |
| Hunan Cancer Hospital - Oncology Department Changsha, Hunan | |
| I.A.Ü. VM Medical Park Florya Hastanesi Küçükçekmece, | |
| I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena -- Oncologia Medica 2 Rome, Lazio | |
| IPO Porto Porto, | |
| Institut Bergonié - Unicancer Nouvelle Aquitaine Bordeaux, | |
| Institut Catala d'Oncologia (ICO) - Hospital Universitari Germans Trias i Pujol (HUGTP) Location Badalona, | |
| Institut Coeur Poumon CHRU Lille - Pole Cardio-vasculaire et pulmonaire Lille, | |
| Institut Curie - Paris - Oncologie medicale Paris, | |
| Institut de Cancerologie Ouest - Saint-Herblain Saint-Herblain, | |
| Instituto Argentino de Diagnostico y Tratamiento (IADT) TBC, | |
| Instituto Nacional De Cancerologia Bogota, Cundinamarca | |
| Institutul Oncologic Prof. Dr. Alexandru Trestioreanu (IOB); Oncologie Medicala II Bucharest, | |
| Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca, | |
| Irmandade Santa Casa de Misericordia de Porto Alegre | Oncology Porto Alegre, Rio Grande do Sul | |
| Istanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçin Sehir Hastanesi Kadıköy, | |
| Istituto Europeo di Oncologia s.r.l - Oncologia Toracica Milan, Lombardy | |
| Istituto Oncologico Veneto_Padova - UOC Oncologia 2 Padua, Veneto | |
| Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. - GDP Toracica Meldola, Emilia-Romagna | |
| Jewish General Hospital - Department of Pulmonary Oncology Montreal, Quebec | |
| Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University Nanjing, | |
| Jilin Cancer Hospital Changchun, | |
| John B. Amos Cancer Center Columbus, Georgia | |
| Kansai Medical University Hospital Hirakata, Osaka | |
| Kantonsspital Baden Baden, | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung City, | |
| Kindai University Hospital Sayama, Osaka | |
| Kitasato University Hospital Sagamihara, Kanagawa | |
| Klinik Floridsdorf, Pneumo-onkologische Ambulanz und Tagesklinik Vienna, | |
| Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik Cologne, North Rhine-Westphalia | |
| Klinikum Nürnberg - Klinik für Innere Medizin 3, Schwerpunkt Pneumologie (Lungenheilkunde) Nuremberg, | |
| Kobe University Hospital Kobe, Hyōgo | |
| Komarom-Esztergom Varmegyei Szent Borbala Korhaz Tatabánya, | |
| Krajská nemocnice T. Bati - Pneumoonkologická a klinická onkologie Zlín, Zlín | |
| Kyiv City Clinical Oncology Center - Department of Chemotherapy #1 Kyiv, | |
| LLC "RDP Ukraine" - Medical Department Dnipro, | |
| Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica Natal, Rio Grande do Norte | |
| Limited Liability Company "MedOffice Group Medical Center" Kyiv, | |
| LinYi Cancer Hospital (Linyi Tumor Hospital) Linyi, | |
| Lungenklinik Hemer, Thorakale Onkologie und onkologische Palliativmedizin Hemer, | |
| M Health Fairview Masonic Cancer Clinic - Clinics and Surgery Center Minneapolis, Minnesota | |
| MHAT "Heart and brain" Pleven Pleven, | |
| MHAT Park Hospital EOOD Plovdiv, | |
| MHAT Serdika Sofia, | |
| MHAT Sveta Marina EAD Varna, | |
| MHAT Uni Hospital Panagyurishte, Pazardzhik | |
| MNCE "Uzhhorod City Multidisciplinary Clinical Hospital" -Oncology Department Uzhhorod, | |
| Marmara University Hospital Istanbul, | |
| Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP) Brno, | |
| Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy w Otwocku Otwock, | |
| Medical Center LLC "Verum Expert Clinic" Kyiv, | |
| Medizinische Universität Wien Universitätsklinik f. Innere Medizin I Klinische Abteilung für Onkologie Vienna, | |
| Memorial Cancer Institute at Miramar Miramar, Florida | |
| Metropolitan Hospital- 4th Oncology Clinic Piraeus, | |
| Moffitt Cancer Center Tampa, Florida | |
| Moffitt Cancer Center - Magnolia Campus Tampa, Florida | |
| Multiprofile Hospital for Active Treatment "Sveta Sofia" Sofia, | |
| Municipal Enterprise Rivne Regional Antitumor Center of the Rivne Regional Council, Abdominal department Rivne, | |
| NAIC - Instituto do Cancer Bauru, | |
| NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School Nanjing, Jiangsu | |
| Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej Warsaw, Masovian Voivodeship | |
| Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej Warsaw, Masovian Voivodeship | |
| National Cancer Center Hospital East Chiba, Kashiwa, | |
| National Cheng Kung University Hospital Tainan, | |
| National Hospital Organization Himeji Medical Center Himeji-Shi, Hyōgo | |
| National Hospital Organization Kyushu Medical Center Fukuoka, Fukuoka | |
| National Hospital Organization Nagoya Medical Center Nagoya, Aichi-ken | |
| National Hospital Organization-Yamaguchi-Ube Medical Center (Sanyo Hospital) Ube, Yamaguchi | |
| National Taiwan University Hospital Taipei, | |
| National Taiwan University Hospital (NTUH) - Cancer Research Center Taipei, | |
| Nederlands Kanker Instituut Amsterdam, | |
| Nemocnice AGEL Nový Jicín a.s. - Oddelení radioterapie a onkologie Nový Jicín, | |
| Nemocnice AGEL Ostrava-Vítkovice a. s. - Plicní oddelení Ostrava - Vítkovice, | |
| Niigata Cancer Center Hospital Niigata, | |
| Nippon Medical School - Nippon Medical School Hospital - Cancer Center Bunkyo-ku, Tokyo | |
| Norrland University Hospital - Cancercentrum Umeå, | |
| ONCARE Treatment Center San Pedro Garza García, | |
| Odense University Hospital - Oncology Department Odense C, | |
| Oncare Viaducto Nápoles Mexico City, | |
| OncoCare Cancer Centre | Gleneagles Medical Centre Singapore, | |
| Oncocenter Puebla City, | |
| Oncologia Integral Satelite Naucalpan, | |
| Osaka International Cancer Institute Osaka, Osaka, | |
| Ospedale San Raffaele s.r.l. - Oncologia Medica Milan, | |
| Ospedale Vito Fazzi Lecce - Oncologia Lecce, | |
| PAPANIKOLAOU General Hospital of Thessaloniki Thessaloniki, | |
| POKO Poprad s.r.o. Poprad, | |
| Patty & George Hoag Cancer Center Newport Beach, California | |
| Piedmont Cancer Institute - Atlanta Atlanta, Georgia | |
| Prince of Wales Hospital Grimsby, | |
| Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology Toronto, Ontario | |
| Private Enterprise Private Production Company "Acinus", Treatment and Diagnostic Center Kropyvnytskyi, | |
| Profound Research - OMG - Royal Oak Cancer Center Royal Oak, Michigan | |
| Profound Research -OMG - TriAtria Cancer Center Farmington Hills, Michigan | |
| Pronutrir Fortaleza - CE Fortaleza, | |
| Providence Cancer Institute - Franz Clinic Portland, Oregon | |
| Providence Oncology and Hematology Care Clinic Westside Portland, Oregon | |
| Pusan National University Yangsan Hospital Yangsan, Gyeongsangnam-do | |
| Queen Elizabeth Hospital Hong Kong Hong Kong, | |
| Queen Mary Hospital Hong Kong, | |
| R.J. Zuckerberg Cancer Center New Hyde Park, New York | |
| Radboud University Medical Center | Afdeling Interne Geneeskunde Nijmegen, | |
| Radiotherapy Center Cluj SRL Flore?ti, Comuna Floresti | |
| Raffles Cancer Centre Singapore, | |
| Rede DoR Recife - PE Recife, Pernambuco | |
| Regionshospitalet Gødstrup - Medicinsk afdeling Herning, | |
| Rigshospitalet - Kræftbehandling Copenhagen OE, | |
| Robert Bosch Krankenhaus - Haematologie, Onkologie und Palliativmedizin Stuttgart, | |
| Royal Surrey County Hospital Guildford, Surrey | |
| S.C Ovidius Clinical Hospital SRL - Oncology Department Ovidiu, | |
| Saitama Cancer Center Kitaadachi-gun, Saitama | |
| Sakarya Universitesi Egitim ve Arastirma Hastanesi Sakarya, | |
| Samsung Medical Center - Oncology Department Seoul, | |
| Sc Oncolab Srl Craiova, Dolj | |
| Sendai Kousei Hospital Miyagi, | |
| Seoul National University Hospital Seoul, | |
| Severance Hospital, Yonsei University Health System - Oncology Department Seoul, Seoul Teugbyeolsi | |
| Shaare Zedek Medical Center (SZMC) Jerusalem, | |
| Shandong University - Shandong Cancer Hospital Jinan, | |
| Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai, Shanghai Municipality | |
| Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department Hangzhou, Zhejiang | |
| Skane University Hospital Lund, Skåne County | |
| Soroka Medical Center- Legacy Heritage Cancer Center Beersheba, | |
| Specialized Hospital for Active Treatment of Oncology Sofia, | |
| Spitalul Clinic Coltea Bucharest, | |
| Sunway Medical Centre Subang Jaya, Selangor | |
| Sunway Medical Centre Penang Perai, | |
| Swietokrzyskie Centrum Onkologii Kielce, | |
| Taichung Veterans General Hospital Taichung, China | |
| Taipei Veterans General Hospital Taipei, Beitou District / R.o.c. | |
| Tan Tock Seng Hospital Singapore, | |
| Tel-Aviv Sourasky Medical Center Tel Aviv, | |
| The Canberra Hospital (TCH) - Canberra Region Cancer Centre (CRCC) Garran, | |
| The Oncology Institute of Hope and Innovation - Fort Lauderdale 17th Street Fort Lauderdale, Florida | |
| The People's Liberation Army General Hospital (Beijing 301 Hospital) Beijing, | |
| The University of Chicago Medical Center - Hyde Park - Hematology & Oncology Chicago, Illinois | |
| The University of Texas MD Anderson Cancer Center - Texas Medical Center Houston, Texas | |
| Torbay Hospital Torquay, | |
| Tottori University Hospital Yonago, Tottori | |
| Turun Yliopistollinen keskussairaala Turku, | |
| UC Medical Center - Oncology Cincinnati, Ohio | |
| UC San Diego Health - Moores Cancer Center San Diego, California | |
| UCLA Health Santa Monica Cancer Care Santa Monica, California | |
| UCSF Bakar Precision Cancer Medicine Building - Thoracic Surgery and Oncology San Francisco, California | |
| UM Greenebaum Comprehensive Cancer Center Baltimore, Maryland | |
| UMass Memorial Medical Center - University Campus - Hematology/Oncology Worcester, Massachusetts | |
| UZ Leuven Gasthuisberg - Pneumology Department Leuven, Vlaams-Brabant | |
| Unidade Local Saúde Coimbra, E.P.E Coimbra, | |
| Uniklinikum Salzburg, Universitätsklinik für Innere Medizin III Salzburg, | |
| Uniklinikum Salzburg, Universitätsklinik für Pneumologie/ Lungenheilkunde Salzburg, | |
| Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech Wuhan, Hubei | |
| Universitaetsklinikum Essen - Innere Klinik (Tumorforschung) Essen, North Rhine-Westphalia | |
| Universitaetsklinikum Giessen und Marburg - Medizinische Klinik IV Organonkologie Giessen, Hesse | |
| University General Hospital ATTIKON, Department of Internal Medicine IV Chaïdári, | |
| University General Hospital of Athens "ATTIKON" Chaïdári, | |
| University General Hospital of Larissa Larissa, | |
| University Hospital Kebangsaan Malaysia Cheras, | |
| University Hospital Simmons Cancer Center Lung/Head Neck Clinic Dallas, Texas | |
| University Malaya Medical Centre Kuala Lumpur, | |
| University Multiprofile Hospital For Active Treatment Sofiamed OOD, Sofia Sofia, | |
| University of Athens Medical School-Sotiria General Hospital - 3rd Dept of Medicine & Medical Oncology Athens, | |
| University of Electronic Science & Technology of China - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital) Chengdu, Sichuan | |
| University of Illinois Hospital - Outpatient Cancer Care Center Chicago, Illinois | |
| University of the Sunshine Coast Sippy Downs, Queensland | |
| Universitätsklinikum Frankfurt - Medizinische Klinik II, Hämatologie und Onkologie Frankfurt, | |
| Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi Lodz, | |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Bialystok, | |
| Velindre University NHS Trust | Velindre Cancer Centre - Clinical Trials Unit Cardiff, | |
| Virginia Commonwealth University Richmond, Virginia | |
| Volyn Regional Oncology Center Lutsk, | |
| West China Hospital Sichuan University Chengdu, Sichuan | |
| Wielkopolskie Centrum Pulmonologii i Torakochirurgii Poznan, | |
| Xiamen University - The First Affiliated Hospital Xiamen, | |
| Zhejiang Cancer Hospital Zhejiang, | |
| Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province Taizhou, Zhejiang | |
| Zhongshan Hospital, Fudan University - Oncology Department Shanghai, | |
| hopital Emile Muller - Service Pneumologie Mulhouse, | |
| hopital Lyon sud HCL - Pneumologie aigue specialisee et cancerologie thoracique Pierre-Bénite, | |
| hopital cochin APHP - service de pneumologie Paris, | |
| hospital Italiano de Buenos Aires Ciudad Autonoma Buenos Aires, |
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
Toll Free Number - Trialsites@msd.com
NCT06136559
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
The main inclusion criteria include but are not limited to the following:
* Confirmed diagnosis of CLL/SLL and active disease clearly documented to have a need to initiate therapy.
* Has at least 1 marker of disease burden.
* Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 within 7 days before randomization.
* Has the ability to swallow and retain oral medication.
* Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks and have undetectable HBV deoxyribonucleic acid (DNA) viral load before randomization.
* Participants with history of hepatitis C virus (HCV) infection are eligible if HCV ribonucleic acid (RNA) viral load is undetectable at screening.
* Participants with human immunodeficiency virus (HIV) who meet ALL eligibility criteria.
Exclusion Criteria:
The main exclusion criteria include but are not limited to the following:
* Has an active hepatitis B virus/ hepatitis C virus (HBV/HCV) infection.
* Has gastrointestinal (GI) dysfunction that may affect drug absorption.
* Has diagnosis of Richter Transformation or active central nervous system (CNS) involvement by CLL/SLL.
* Has had acquired immune deficiency syndrome (AIDS)-defining opportunistic infection in the past 12 months before screening.
* Has clinically significant cardiovascular disease.
* Has hypersensitivity to nemtabrutinib or contraindication to ibrutinib or acalabrutinib, or any of the excipients.
* Has history of severe bleeding disorder.
* Has known additional malignancy that is progressing or has required active treatment within the past 2 years.
* Has received any systemic anticancer therapy for CLL/SLL.
* Is currently being treated with p-glycoprotein (P-gp) substrates with a narrow therapeutic index, cytochrome P450 3A (CYP3A) strong or moderate inducers or CYP3A strong inhibitors.
* Received prior radiotherapy within 2 weeks of start of study intervention, or radiation-related toxicities, requiring corticosteroids.
* Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines are allowed.
* Has received an investigational agent or has used an investigational device within 4 weeks before study intervention administration.
* Has active infection requiring systemic therapy, including intravenous (IV) antibiotics during screening.
* Participants who have not adequately recovered from major surgery or have ongoing surgical complications. DRUG: Nemtabrutinib, DRUG: Ibrutinib, DRUG: Acalabrutinib
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
I'm interested
Share via email
Show 190 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0205) Mechelen, Antwerpen | |
| Aalborg Universitetshospital, Syd ( Site 0403) Aalborg, North Denmark | |
| Akershus Universitetssykehus ( Site 0902) Lørenskog, Akershus | |
| Alta Bates Summit Medical Center ( Site 0004) Berkeley, California | |
| Anhui Provincial Cancer Hospital ( Site 2001) Hefei, Anhui | |
| Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1407) Ankara, | |
| Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 1401) Ankara, | |
| Antalya Egitim ve Arastırma Hastanesi ( Site 1409) Antalya, | |
| Aotearoa Clinical Trials ( Site 3201) Auckland, | |
| Arizona Oncology Associates - NAHOA ( Site 8007) Prescott, Arizona | |
| BC Cancer Kelowna ( Site 0112) Kelowna, British Columbia | |
| BC Cancer Victoria ( Site 0109) Victoria, British Columbia | |
| Barnet Hospital ( Site 3005) Barnet, | |
| Bnai Zion Medical Center ( Site 1505) Haifa, | |
| Bradfordhill-Clinical Area ( Site 2310) Santiago, Region M. de Santiago | |
| Cancer Care Associates Of York ( Site 0005) York, Pennsylvania | |
| Cancer Institute Hospital of JFCR ( Site 1906) Koto, Tokyo | |
| Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski ( Site 0100) Rimouski, Quebec | |
| Centro Medico Monte Carmelo-Oncology ( Site 2706) Arequipa, Ariqipa | |
| Centro de Infusion Superare ( Site 2602) Mexico City, Mexico City | |
| Champalimaud Foundation ( Site 3102) Lisbon, Lisbon District | |
| Chang Gung Medical Foundation-Linkou Branch ( Site 1703) Taoyuan District, | |
| Chang Gung Memorial Hospital at Kaohsiung-Division of Hematology and Oncology ( Site 1702) Kaohsiung City, | |
| Chiba Cancer Center ( Site 1905) Chiba, | |
| Chongqing University Cancer Hospital ( Site 2041) Chongqing, Chongqing Municipality | |
| Chulalongkorn University ( Site 1802) Bangkok, Bangkok | |
| City Hospital, Nottingham University Hospitals NHS Trust ( Site 3003) Nottingham, | |
| Clermont Oncology Center ( Site 0046) Clermont, Florida | |
| Clínica Alemana de Santiago-Unidad de Investigaciones ( Site 2306) Santiago, Region M. de Santiago | |
| Clínica Anglo Americana ( Site 2701) Lima, | |
| Constantiaberg Haematology ( Site 1106) Plumstead, Western Cape | |
| Consultants in Medical Oncology and Hematology (CMOH) ( Site 8002) Broomall, Pennsylvania | |
| Corewell Health-Lemmon Holton Cancer Pavilion ( Site 0011) Grand Rapids, Michigan | |
| Eastern CT Hematology & Oncology Associates ( Site 0033) Norwich, Connecticut | |
| Ege Universitesi Hastanesi ( Site 1404) Izmir, | |
| Evangelismos General Hospital of Athens ( Site 0700) Athens, Attica | |
| FALP-UIDO ( Site 2300) Santiago, Region M. de Santiago | |
| Faculty of Medicine Siriraj Hospital-Division of Hematology, Department of Medicine ( Site 1801) Bangkok, Bangkok | |
| Fakultni nemocnice Hradec Kralove-IV. interni hematologicka klinika ( Site 0301) Hradec Králové, | |
| Fakultni nemocnice Olomouc ( Site 0303) Olomouc, | |
| Florida Cancer Specialists - East ( Site 7002) West Palm Beach, Florida | |
| Florida Cancer Specialists - South ( Site 7001) Fort Myers, Florida | |
| Fundacion Valle del Lili- CIC-Oncology CIC ( Site 2402) Cali, Valle del Cauca Department | |
| Galilee Medical Center ( Site 1507) Nahariya, | |
| General Hospital of Athens "Laiko" ( Site 0704) Athens, Attica | |
| GenesisCare - Bristol ( Site 3011) Bristol, South Gloucestershire | |
| GenesisCare - Cambridge ( Site 3001) Newmarket, Suffolk | |
| GenesisCare - Windsor ( Site 3002) Windsor, Windsor And Maidenhead | |
| Groote Schuur Hospital-Clinical Haematology ( Site 1100) Cape Town, Western Cape | |
| Guangxi Medical University Affiliated Tumor Hospital ( Site 2004) Nanning, Guangxi | |
| Gunma University Hospital ( Site 1903) Maebashi, Gunma | |
| HOSPITAL CLÍNIC DE BARCELONA ( Site 1202) Barcelona, Catalonia | |
| HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 1208) Majadahonda, Madrid, Comunidad de | |
| HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1209) Pozuelo de Alarcón, Madrid | |
| Hadassah Medical Center-Hemato-Oncology ( Site 1500) Jerusalem, | |
| Haemalife ( Site 1105) Kuilsriver, Western Cape | |
| Hainan General Hospital ( Site 2018) Haikou, Hainan | |
| Health Pharma Professional Research S.A. de C.V: ( Site 2608) Mexico City, Mexico City | |
| Henan Cancer Hospital-hematology department ( Site 2025) Zhengzhou, Henan | |
| Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 1913) Hiroshima, | |
| Hokkaido University Hospital ( Site 1900) Sapporo, Hokkaido | |
| Hospital 9 De Julho ( Site 2206) São Paulo, São Paulo | |
| Hospital Paulistano-Americas Oncologia ( Site 2202) São Paulo, | |
| Hospital Pulau Pinang ( Site 1602) George Town, Pulau Pinang | |
| Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1206) Barcelona, | |
| Hospital Universitario de Salamanca - Complejo Asistencial U-Servicio de Hematologia ( Site 1201) Salamanca, | |
| Hunan Cancer Hospital ( Site 2020) Changsha, Hunan | |
| IMAT S.A.S ( Site 2401) Montería, Departamento de Córdoba | |
| InVO Institut für Versorgungsforschung in der Onkologie ( Site 0606) Koblenz, Rhineland-Palatinate | |
| Inova Schar Cancer Institute ( Site 0015) Fairfax, Virginia | |
| Institut Català d'Oncologia - L'Hospitalet-Haematology Department ( Site 1207) L'Hospitalet Del Llobregat, Barcelona | |
| Institute of hematology&blood disease hospital-Lymphoma ( Site 2005) Tianjin, Tianjin Municipality | |
| Instituto Nacional de Câncer - INCA ( Site 2201) Rio de Janeiro, | |
| Instituto Português de Oncologia de Lisboa Francisco Gentil ( Site 3103) Lisbon, Lisbon District | |
| Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 3100) Porto, | |
| Intermountain Health St. Mary's Regional Hospital ( Site 0025) Grand Junction, Colorado | |
| Japanese Red Cross Osaka Hospital ( Site 1908) Osaka, | |
| Jiangsu Province Hospital ( Site 2000) Nanjing, Jiangsu | |
| Jiangxi Provincial Cancer Hospital ( Site 2009) Nanchang, Jiangxi | |
| John Theurer Cancer Center at Hackensack University Medical Center ( Site 0016) Hackensack, New Jersey | |
| Karolinska Universitetssjukhuset Solna ( Site 1302) Stockholm, Stockholm County | |
| Kindai University Hospital ( Site 1909) Sakai, Osaka | |
| Kliniken Maria Hilf ( Site 0603) Mönchengladbach, North Rhine-Westphalia | |
| Kobe City Medical Center General Hospital ( Site 1910) Kobe, Hyōgo | |
| Kyushu University Hospital ( Site 1914) Fukuoka, | |
| Liuzhou People's Hospital ( Site 2029) Liuzhou, Guangxi | |
| Lutheran Medical Center ( Site 0027) Golden, Colorado | |
| Maharaj Nakorn Chiang Mai Hospital ( Site 1800) Muang, Chiang Mai | |
| Marmara Universitesi Pendik Egitim Arastirma Hastanesi ( Site 1408) Istanbul, | |
| McGill University Health Centre ( Site 0106) Montreal, Quebec | |
| Medical Oncology Associates, PS (dba Summit Cancer Centers) ( Site 0010) Spokane, Washington | |
| Mega Medipol ( Site 1412) Istanbul, | |
| MidAmerica Cancer Care, LLC ( Site 0043) Kansas City, Missouri | |
| Moores Cancer Center ( Site 0003) La Jolla, California | |
| Nagoya University Hospital ( Site 1907) Nagoya, Aichi-ken | |
| Naresuan University Hospital ( Site 1804) Muang, Changwat Phitsanulok | |
| Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1000) Gliwice, Silesian Voivodeship | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site 1004) Warsaw, Masovian Voivodeship | |
| National Cheng Kung University Hospital ( Site 1700) Tainan, | |
| National Taiwan University Hospital ( Site 1701) Taipei, | |
| Netcare Pretoria East Hospital-Alberts Cellular Therapy ( Site 1101) Pretoria, Gauteng | |
| North Shore Hospital-Department of Haematology ( Site 3200) Auckland, | |
| Odense Universitetshospital-Department of Hematology ( Site 0401) Odense C, Region Syddanmark | |
| Okayama University Hospital ( Site 1912) Okayama, | |
| Oncology Specialists of Charlotte ( Site 0054) Charlotte, North Carolina | |
| Ondokuz Mays Üniversitesi ( Site 1410) Samsun, | |
| Onkologische Schwerpunktpraxis Kurfuerstendamm ( Site 0600) Berlin, | |
| Oslo Universitetssykehus Rikshospitalet-Avdeling for blodsykdommer ( Site 0901) Oslo, | |
| Parkview Research Center at Parkview Regional Medical Center ( Site 0002) Fort Wayne, Indiana | |
| Peking University First Hospital ( Site 2022) Beijing, Beijing Municipality | |
| Peking University Third Hospital-Hematology ( Site 2011) Beijing, Beijing Municipality | |
| Pratia MCM Krakow ( Site 1007) Krakow, Lesser Poland Voivodeship | |
| Pratia Onkologia Katowice ( Site 1009) Katowice, Silesian Voivodeship | |
| Queen Elizabeth Hospital ( Site 1603) Kota Kinabalu, Sabah | |
| Queen Mary Hospital ( Site 3300) Hong Kong, | |
| Rabin Medical Center ( Site 1504) Petah Tikva, | |
| Rambam Health Care Campus-Hematology and Bone Marrow Transplantation ( Site 1503) Haifa, | |
| Regions Hospital ( Site 0042) Saint Louis Park, Minnesota | |
| Roskilde Sygehus-Department of Hematology ( Site 0402) Roskilde, Region Sjælland | |
| Roswell Park Cancer Institute ( Site 0023) Buffalo, New York | |
| Royal Lancaster Infirmary ( Site 3012) Lancaster, Lancashire | |
| Royal North Shore Hospital ( Site 2806) St Leonards, New South Wales | |
| SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical ( Site 0048) Madison, Wisconsin | |
| Saint Elizabeth Healthcare ( Site 0041) Edgewood, Kentucky | |
| Saint Joseph Hospital ( Site 0026) Denver, Colorado | |
| Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Olsztynie-Oddzial Kliniczny Hematologii ( Site 1005) Olsztyn, Warmian-Masurian Voivodeship | |
| Shaanxi provincial people's hospital ( Site 2012) Xi'an, Shaanxi | |
| Shandong Cancer Hospital ( Site 2003) Jinan, Shandong | |
| Shanxi Cancer Hospital ( Site 2033) Taiyuan, Shanxi | |
| Sheba Medical Center-Hemato Oncology ( Site 1501) Ramat Gan, | |
| Shimane University Hospital ( Site 1911) Izumo, Shimane | |
| Sisli Florence Nightingale Hastanesi ( Site 1411) Istanbul, | |
| Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 2405) Valledupar, Cesar Department | |
| Songklanagarind hospital ( Site 1803) Hat Yai, Changwat Songkhla | |
| Southeastern Medical Oncology Center ( Site 0049) Goldsboro, North Carolina | |
| Southern Medical University Nanfang Hospital-Department of Hematopathology ( Site 2006) Guangzhou, Guangdong | |
| Southmead Hospital ( Site 3010) Bristol, Bristol, City of | |
| St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 3006) London, London, City of | |
| St James's University Hospital ( Site 3004) Leeds, | |
| Summit Medical Group Cancer Center ( Site 0007) Florham Park, New Jersey | |
| Sun Yat-sen University Cancer Center ( Site 2028) Guangzhou, Guangdong | |
| Sykehuset i Vestfold ( Site 0903) Tønsberg, Vestfold | |
| TENNESSEE ONCOLOGY ( Site 0031) Nashville, Tennessee | |
| Tennessee Oncology-Chattanooga ( Site 0045) Chattanooga, Tennessee | |
| Texas Oncology - Central/South Texas ( Site 8008) Austin, Texas | |
| Texas Oncology - Northeast Texas ( Site 8012) Tyler, Texas | |
| Texas Oncology - San Antonio ( Site 8006) San Antonio, Texas | |
| The Affiliated Hospital of Guizhou Medical University ( Site 2024) Guiyang, Guizhou | |
| The Affiliated Hospital of Xuzhou Medical College ( Site 2013) Xuzhou, Jiangsu | |
| The Center for Cancer and Blood Disorders ( Site 0032) Fort Worth, Texas | |
| The Churchill Hospital ( Site 3007) Oxford, Oxfordshire | |
| The First Affiliated Hospital of Nanchang University ( Site 2023) Nanchang, Jiangxi | |
| The First Affliated Hospital of Suzhou University ( Site 2027) Suzhou, Jiangsu | |
| The First Hospital of Jilin University-Hematology ( Site 2030) Changchun, Jilin | |
| The Ottawa Hospital - General Campus ( Site 0102) Ottawa, Ontario | |
| The Second Xiangya Hospital of Central South University ( Site 2010) Changsha, Hunan | |
| The first Affiliated Hospital, Zhejiang University School of Medicine-Hematology ( Site 2002) Hangzhou, Zhejiang | |
| Tianjin Medical University Cancer Institute & Hospital-lymphoma ( Site 2019) Tianjin, Tianjin Municipality | |
| Tohoku University Hospital ( Site 1901) Sendai, Miyagi | |
| Tongji Hospital Affiliated to Tongji Medical College of HUST ( Site 2016) Wuhan, Hubei | |
| Trakya University-Balkan Onkoloji Hastanesi ( Site 1403) Edirne, | |
| USA Mitchell Cancer Institute ( Site 0014) Mobile, Alabama | |
| UZ Leuven-Hematology ( Site 0200) Leuven, Vlaams-Brabant | |
| Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 3107) Vila Nova de Gaia, Porto District | |
| Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 3104) Lisbon, | |
| Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 3106) Lisbon, | |
| Universitaetsklinikum Ulm. ( Site 0601) Ulm, Baden-Wurttemberg | |
| University Hospital and UW Health Clinics ( Site 0006) Madison, Wisconsin | |
| University Hospital of Alexandroupolis ( Site 0701) Alexandroupoli, East Macedonia and Thrace | |
| University Hospital of Ioannina ( Site 0702) Ioannina, | |
| University Malaya Medical Centre ( Site 1604) Lembah Pantai, Kuala Lumpur | |
| University of Iowa-Holden Comprehensive Cancer Center ( Site 0017) Iowa City, Iowa | |
| University of Virginia Cancer Center ( Site 0040) Charlottesville, Virginia | |
| Universitätsklinikum Halle ( Site 0604) Halle, Saxony-Anhalt | |
| Uniwersytecki Szpital Kliniczny nr 1 w Lublinie-Oddział Hematoonkologii-Transplantacji Szpiku i Chem ( Site 1006) Lublin, Lublin Voivodeship | |
| Uniwersyteckie Centrum Kliniczne-Klinika Hematologii i Transplantologii ( Site 1011) Gdansk, Pomeranian Voivodeship | |
| VK&K Studien GbR ( Site 0607) Landshut, Bavaria | |
| Virginia Commonwealth University (VCU) Medical Center ( Site 0030) Richmond, Virginia | |
| Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0302) Prague, | |
| Waikato Hospital-Haematology ( Site 3202) Hamilton, Waikato Region | |
| West China Hospital, Sichuan University-Head and Neck Oncology ( Site 2026) Chengdu, Sichuan | |
| William Osler Health System ( Site 0103) Brampton, Ontario | |
| Wits Clinical Research ( Site 1102) Johannesburg, Gauteng | |
| Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku-Oddział Hematologii i Transplantacji ( Site 1013) Słupsk, Pomeranian Voivodeship | |
| Wuhan Union Hospital ( Site 2015) Wuhan, Hebei | |
| Xinjiang Medical University Cancer Hospital - Urumqi ( Site 2014) Ürümqi, Xinjiang | |
| Yamagata University Hospital ( Site 1902) Yamagata, | |
| Yitzhak Shamir Medical Center. ( Site 1506) Ẕerifin, | |
| Zhejiang Cancer Hospital ( Site 2017) Hangzhou, Zhejiang | |
| hospital universitario de canarias ( Site 1205) San Cristóbal de La Laguna, Santa Cruz De Tenerife |
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma (SUPRAME)
Immatics US, Inc. - ctgovinquiries@immatics.com
NCT06743126
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Pathologically confirmed and documented cutaneous melanoma- CM patients (including acral melanoma) with unresectable or metastatic disease
* HLA-A\*02:01 positive
* Adequate selected organ function per protocol
* Eastern Cooperative Oncology Group (ECOG) performance status 0-1
* Disease progression (resistance, toxicity) on or after at least one PD-1 inhibitor, applied either as monotherapy or in combination with other therapies as treatment for unresectable or metastatic cutaneous melanoma
* Patients with BRAF mutation should have been treated with one prior line of BRAF-directed therapy (with or without a MEK inhibitor) prior to initial eligibility assessment, unless deemed not clinically indicated at Investigator's discretion due to concurrent medical condition, prior toxicity, or if declined by the patient
* Life expectancy more than 6 months
* Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1)
* Female patient of childbearing potential must use adequate contraception from randomization until 12 months after the infusion of IMA203 or in line with the instructions provided for investigator's choice treatment (in the control arm)
* Male patient must agree to use effective contraception or be abstinent while on study and for 6 months after the infusion of IMA203 or in line with the instructions provided for investigator's choice treatment (in the control arm)
* The patient must have recovered from any side effects of prior therapy to Grade 1 or lower prior to randomization.
Exclusion Criteria:
* Primary mucosal or uveal melanoma and melanoma of unknown primary
* History of other malignancies (except for adequately treated basal or squamous cell carcinoma or carcinoma in situ) within the last 3 years
* Serious autoimmune disease Note: At the discretion of the investigator, these patients may be included if their disease is well controlled without the use of immunosuppressive agents.
* History of cardiac conditions as per protocol
* Prior allogenic stem cell transplantation or solid organ transplantation
* Concurrent severe and/or uncontrolled medical disease that could compromise participation in the study
* History of or current immunodeficiency disease or prior treatment compromising immune function at the discretion of the treating physician
* History of hypersensitivity to CY, FLU, or IL-2 or presence of any contraindications and other limitations for planned treatment with investigator's choice as laid down in the current versions of the respective PIs / SmPCs
* Known hypersensitivity to any of the rescue medications
* History of or current immunodeficiency disease or prior treatment compromising immune function at the discretion of the investigator
* Positive for HIV infection or with active hepatitis B virus (HBV) or active hepatitis C virus (HCV) infection.
* Any condition contraindicating leukapheresis
* Pregnant or breastfeeding
* Any other condition that would, in the investigator's or sponsor's judgment, contraindicate the patient's participation in the clinical trial because of safety concerns or compliance with clinical trial procedures (e.g., psychiatric disorders or substance dependence, neurological impairment)
* Patient has received systemic corticosteroids within 2 weeks prior to leukapheresis,
* Patient has received surgery or other anti-cancer therapies, any agent that is likely to suppress bone marrow function, or investigational medicinal products within 7 days prior to leukapheresis.
* Patients with any active infection or ongoing reactivation of infection
* Patients who underwent non-myeloablative lymphodepletion prior to cell therapy within the last 6 months
* Prior treatment with IMA203
* Patients with ascites, pleural or pericardial effusion which requires repeated (2 within 4 weeks) or continuous paracentesis, thoracentesis or pericardiocentesis within last 2 months
* Patients with LDH greater than 2.0-fold ULN
* Concurrent treatment in another clinical trial or a device study that could interfere with the IMA203 treatment or planned investigator's choice treatment
* Patients with active brain metastases or leptomeningeal metastases
* Patient has received any investigational therapies, inactivated vaccines, chronic use of systemic corticosteroids or IV antibiotics within 1 week prior to randomization, or live vaccines within 4 weeks prior to randomization
* Patient has received any anti-cancer therapy (prior anti-cancer treatment or bridging therapy) or radiotherapy within 1 week prior to start of trial treatment
* Other protocol defined inclusion/exclusion criteria could apply BIOLOGICAL: IMA203, BIOLOGICAL: nivolumab plus relatlimab, BIOLOGICAL: lifileucel, BIOLOGICAL: nivolumab, BIOLOGICAL: pembrolizumab, BIOLOGICAL: ipilimumab, DRUG: Dacarbazine, DRUG: temozolomide, DRUG: paclitaxel, DRUG: paclitaxel plus carboplatin, DRUG: Albumin-Bound Paclitaxel
Melanoma, Cutaneous Malignant
I'm interested
Share via email
Show 41 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Atlantic Health System/Morristown Medical Center Morristown, New Jersey | |
| Avera Cancer Institute Sioux Falls, South Dakota | Benjamin Solomon, MD - (Benjamin.Solomon@avera.org) |
| Baylor University Dallas, Texas | |
| Charite Universitaetsmedizin Berlin KöR Berlin, | |
| City of Hope National Medical Center Duarte, California | Yan Xing, MD - (yxing@coh.org) |
| Cleveland Clinic, Taussig Cancer Institute Cleveland, Ohio | James Isaac - (isaacsj3@ccf.org) |
| Fox Chase Cancer Center Philadelphia, Pennsylvania | Anthony J Olszanski, MD, RPh - (Anthony.Olszanski@FCCC.edu) |
| Fred Hutchinson Cancer Center Seattle, Washington | Sylvia Lee, MD - (leesm@uw.edu) |
| Goethe University Frankfurt Frankfurt am Main, | |
| Honor Health Research Institute Scottsdale, Arizona | Justin Moser, MD - (jmoser@honorhealth.com) |
| Huntsman Cancer Institute, University of Utah Salt Lake City, Utah | Siwen Hu-Lieskovan, MD, PhD - (Siwen.Hu-Leiskovan@hci.utah.edu) |
| Laura and Isaac Perlmutter Cancer Center At Nyu Langone Health New York, New York | Maya Dimitrova, MD - (maya.dimitrova@nyulangone.org) |
| Massachusetts General Hospital Boston, Massachusetts | |
| Memorial Sloan Kettering Cancer Center New York, New York | James Smithy, MD - (smithyj@mskcc.org) |
| Moffitt Cancer Center Tampa, Florida | |
| Ohio State University Columbus, Ohio | |
| Providence Cancer Institute Franz Clinic Portland, Oregon | Matthew Taylor, MD - (Matthew.Taylor@providence.org) |
| SCRI Oncology Partners Nashville, Tennessee | |
| Stanford Cancer Center Palo Alto, California | Alison Betof Warner, MD, PhD - (allison.betof@stanford.edu) |
| Technische Universitaet Dresden Dresden, | |
| The University of Texas MD Anderson Cancer Center Houston, Texas | Rodabe N Amaria, MD - (RNAmaria@mdanderson.org) |
| Thomas Jeffersion University, Sidney Kimmel Cancer Center Philadelphia, Pennsylvania | |
| UCLA Hematology/Oncology Los Angeles, California | Bartosz Chmielowski, MD, PhD - (bchmielowski@mednet.ucla.edu) |
| UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California | |
| UNC Hospitals, The University of North Carolina at Chapel Hill Chapel Hill, North Carolina | Stergios Moschos, MD - (stergios_moschos@med.unc.edu) |
| UPMC Hillman Cancer Center Pittsburgh, Pennsylvania | Jason J Luke, M.D. - (lukejj@upmc.edu) |
| Universitaet Leipzig Leipzig, | |
| Universitaetsklinikum Bonn AöR Bonn, | |
| Universitaetsklinikum Erlangen AöR Erlangen, | |
| Universitaetsklinikum Essen AöR Essen, | |
| Universitaetsklinikum Heidelberg AöR Heidelberg, | |
| Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR Mainz, | |
| University Hospital Cologne AöR Cologne, | |
| University Medical Center Hamburg-Eppendorf Hamburg, City state of Hamburg | |
| University of MD Greenebaum Comprehensive Cancer Center Baltimore, Maryland | Petra Hausner, MD, PhD - (phausner@umm.edu) |
| University of Miami - Sylvester Comprehensive Cancer Cente Miami, Florida | Leonel Hernandez-Aya, MD - (l.hernandezaya@med.miami.edu) |
| University of Nebraska Medical Center Omaha, Nebraska | Bhavina Sharma, MD - (bhsharma@unmc.edu) |
| University of Pennsylvania, Abramson Cancer Center Philadelphia, Pennsylvania | |
| University of Texas Southwestern Medical Center Dallas, Texas | Sanjay Chandrasekaran, MD - (Sanjay.Chandrasekaran@utsouthwestern.edu) |
| Virginia Commonwealth University Richmond, Virginia | Andrew Poklepovic, MD - (andrew.poklepovic@vcuhealth.org) |
| Yale Cancer Center New Haven, Connecticut |
Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors
Director Regulatory Affairs - langerj@nrgoncology.org
NCT05896189
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* The participant must provide study-specific informed consent prior to any study specific procedures and authorization permitting release of personal health information.
* The participant must have a first time diagnosis of non-metastatic breast cancer which is Stage I-III.
* The participant must have a score of less than 12 on the PROMIS Adult v2.0 - Cognitive Function 4a.
* Participants must be at least 6 months and no more than 5 years (after completion of initial surgery +/- adjuvant chemotherapy/radiation therapy) and targeted therapies (e.g., PARP inhibitors, CDK4/6, or immunotherapy). Participants may still be taking endocrine therapy and/or trastuzumab.
* The participant must be able to understand, speak, read, and write in English or Spanish.
Exclusion Criteria:
* Scoring less than or equal to 3 on the 6-item cognitive screen.
* Patient Health Questionnaire-2 item (PHQ-2) score of greater than or equal to 3.
* Definitive clinical or radiologic evidence of metastatic disease.
* Current or past history of another cancer. Patients with history of only non-melanoma skin cancer or in situ cervical cancer without chemotherapy treatment would be eligible.
* Previous exposure to chemotherapy treatment for another cancer or due to other medical condition (e.g. methotrexate exposure for treatment of rheumatoid arthritis).
* Previous central nervous system (CNS) radiation, intrathecal therapy or CNS-involved surgery.
* Participants with history of stroke, traumatic brain injury, brain surgery, Alzheimer's disease or other dementia.
* Participants with active substance abuse and/or in treatment for substance abuse, or history of bipolar disorder, psychosis, schizophrenia, ADHD, or learning disability.
* Participants who are enrolled in an active behavioral intervention (e.g., occupational therapy, physical therapy, etc.) or pharmaceutical intervention or who are in the follow-up phase of a cancer control trial or therapeutic trial that has extensive PRO follow-up after treatment ends. Participants who are enrolled in a therapeutic trial in which they have completed active treatment and require only minimal follow-up monitoring of toxicity and/or survival analysis (cancer-related mortality or all-cause mortality) would be eligible.
* Hearing impairment unless adequately corrected with hearing aids to be able to hear over the phone for the neuropsychological testing. BEHAVIORAL: Arm 1: Computerized Cognitive Training-Global Stimulation Games, BEHAVIORAL: Arm 2: Computerized Cognitive Training-Neuroplasticity Games
Breast Cancer, Cognitive Impairments
I'm interested
Share via email
Show 639 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| AIS Cancer Center at San Joaquin Community Hospital Bakersfield, California | |
| Abbott-Northwestern Hospital Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Addison Gilbert Hospital Gloucester, Massachusetts | |
| Adena Regional Medical Center Chillicothe, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Advanced Breast Care Center PLLC Warren, Michigan | |
| Alaska Breast Care and Surgery LLC Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Alaska Oncology and Hematology LLC Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Alaska Women's Cancer Care Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Alegent Health Bergan Mercy Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Immanuel Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Lakeside Hospital Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Mercy Hospital Council Bluffs, Iowa | |
| Allegiance Health Jackson, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| AnMed Health Cancer Center Anderson, South Carolina | Site Public Contact - (rhonda.ballew@anmedhealth.org) |
| Anchorage Associates in Radiation Medicine Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Anchorage Radiation Therapy Center Anchorage, Alaska | |
| Annie Penn Memorial Hospital Reidsville, North Carolina | Site Public Contact - (stacey.phelps@conehealth.com) |
| Arizona Center for Cancer Care Tempe, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care - Biltmore Phoenix, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care - Gilbert Gilbert, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care - Osborn Scottsdale, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care - Phoenix Phoenix, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care - Scottsdale Scottsdale, Arizona | Site Public Contact - (penny.labriola@arizonaccc.com) |
| Arizona Center for Cancer Care-Peoria Peoria, Arizona | |
| Arizona Center for Cancer Care-Surprise Surprise, Arizona | Site Public Contact - (Roster@nrgoncology.org) |
| Armes Family Cancer Center Findlay, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Ascension Borgess Cancer Center Kalamazoo, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Ascension Borgess Hospital Kalamazoo, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Ascension Via Christi Hospitals Wichita Wichita, Kansas | Site Public Contact - (research@viachristi.org) |
| BASS Medical Group - Lennon Walnut Creek, California | Site Public Contact - (brenna.lindsey@bassmedicalgroup.com) |
| BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri | |
| Baptist Cancer Center-Grenada Grenada, Mississippi | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Desoto Southhaven, Mississippi | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus, Mississippi | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Oxford Oxford, Mississippi | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital and Cancer Center-Union County New Albany, Mississippi | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Baptist Memorial Hospital for Women Memphis, Tennessee | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Bay Area Hospital Coos Bay, Oregon | Site Public Contact - (cherie.cox@bayareahospital.org) |
| Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care Winchester, Massachusetts | |
| Bethesda North Hospital Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Beverly Hospital Beverly, Massachusetts | |
| Bhadresh Nayak MD PC-Sterling Heights Sterling Heights, Michigan | |
| Blanchard Valley Hospital Findlay, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Bon Secours Cancer Institute at Reynolds Crossing Richmond, Virginia | Site Public Contact - (Anne_caramella@bshsi.org) |
| Bon Secours Memorial Regional Medical Center Mechanicsville, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Richmond Community Hospital Richmond, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Saint Francis Medical Center Midlothian, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Saint Mary's Hospital Richmond, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Bon Secours Westchester Emergency Center Midlothian, Virginia | Site Public Contact - (anne_carmellat@bshsi.org) |
| Boulder Community Foothills Hospital Boulder, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Broadlawns Medical Center Des Moines, Iowa | |
| Bronson Battle Creek Battle Creek, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Bronson Methodist Hospital Kalamazoo, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Broward Health Medical Center Fort Lauderdale, Florida | Site Public Contact - (Allison.bruce@nemours.org) |
| Broward Health North Deerfield Beach, Florida | |
| CARTI Cancer center Little Rock, Arkansas | Site Public Contact - (Research@CARTI.com) |
| CHI Health Good Samaritan Kearney, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| CHI Health Saint Francis Grand Island, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| CTCA at Southeastern Regional Medical Center Newnan, Georgia | |
| CTCA at Western Regional Medical Center Goodyear, Arizona | |
| Cancer Care Associates PC Royal Oak, Michigan | |
| Cancer Care Center of O'Fallon O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Care Specialists of Illinois - Decatur Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Center at Saint Joseph's Phoenix, Arizona | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Cancer Center of Kansas - Chanute Chanute, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Dodge City Dodge City, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - El Dorado El Dorado, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - McPherson McPherson, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Newton Newton, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Parsons Parsons, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Pratt Pratt, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Salina Salina, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Wellington Wellington, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Wichita Wichita, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas - Winfield Winfield, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas-Independence Independence, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas-Kingman Kingman, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas-Liberal Liberal, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas | Site Public Contact - (research@viachristi.org) |
| Cancer Center of Western Wisconsin New Richmond, Wisconsin | Site Public Contact - (mmcorc@healthpartners.com) |
| Cancer Center-Metro Medical Center Bayamon Bayamón, | |
| Cancer Hematology Centers - Flint Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan | Site Public Contact - (connie.szczepanek@crcwm.org) |
| Carilion Roanoke Memorial Hospital Roanoke, Virginia | |
| Carle BroMenn Medical Center Normal, Illinois | Site Public Contact - (Research@Carle.com) |
| Carle Cancer Center Urbana, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Cancer Institute Normal Normal, Illinois | Site Public Contact - (Research@Carle.com) |
| Carle Physician Group-Effingham Effingham, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | Site Public Contact - (Research@carle.com) |
| Carle at The Riverfront Danville, Illinois | Site Public Contact - (Research@Carle.com) |
| Caro Cancer Center Caro, Michigan | |
| Castle Medical Center Kailua, Hawaii | Site Public Contact - (Roster@nrgoncology.org) |
| Cedars Sinai Medical Center Los Angeles, California | |
| Central Care Cancer Center - Bolivar Bolivar, Missouri | Site Public Contact - (aroland@kccop.org) |
| Central Care Cancer Center - Garden City Garden City, Kansas | Site Public Contact - (aroland@kccop.org) |
| Central Care Cancer Center - Great Bend Great Bend, Kansas | Site Public Contact - (aroland@kccop.org) |
| Central Ohio Breast and Endocrine Surgery Gahanna, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Centralia Oncology Clinic Centralia, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Centro Comprensivo de Cancer de UPR San Juan, | Site Public Contact - (Roster@nrgoncology.org) |
| Chelsea Hospital Chelsea, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Chester County Hospital West Chester, Pennsylvania | Site Public Contact - (carolann.hoppes@pennmedicine.upenn.edu) |
| Clackamas Radiation Oncology Center Clackamas, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Cleveland Clinic Akron General Akron, Ohio | Site Public Contact - (CancerAnswer@ccf.org) |
| Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center Wilmington, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Colorado Blood Cancer Institute Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Commonwealth Cancer Center-Corbin Corbin, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Community Medical Center Missoula, Montana | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Comprehensive Medical Center PLLC Royal Oak, Michigan | |
| Cone Health Cancer Center Greensboro, North Carolina | Site Public Contact - (stacey.phelps@conehealth.com) |
| Cone Health Cancer Center at Alamance Regional Burlington, North Carolina | Site Public Contact - (stacey.phelps@conehealth.com) |
| Cone Health Cancer Center at Asheboro Asheboro, North Carolina | |
| Cone Health Cancer Center at Drawbridge Parkway Greensboro, North Carolina | Site Public Contact - (stacey.phelps@conehealth.com) |
| Cone Health MedCenter Asheboro Asheboro, North Carolina | Site Public Contact - (stacey.phelps@conehealth.com) |
| Contra Costa Regional Medical Center Martinez, California | |
| Cooper Hospital University Medical Center Camden, New Jersey | |
| Corewell Health Beaumont Troy Hospital Troy, Michigan | |
| Corewell Health Dearborn Hospital Dearborn, Michigan | |
| Corewell Health Farmington Hills Hospital Farmington Hills, Michigan | |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Lakeland Hospitals - Niles Hospital Niles, Michigan | |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Reed City Hospital Reed City, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health William Beaumont University Hospital Royal Oak, Michigan | |
| Cotton O'Neil Cancer Center / Stormont Vail Health Topeka, Kansas | |
| Cox Cancer Center Branson Branson, Missouri | |
| CoxHealth South Hospital Springfield, Missouri | |
| Creighton University Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Crossroads Cancer Center Effingham, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Dayton Physician LLC - Englewood Dayton, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Dayton Physicians LLC - Troy Troy, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Dayton Physicians LLC-Atrium Franklin, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Dayton Physicians LLC-Miami Valley South Centerville, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Dayton Physicians LLC-Wayne Greenville, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Decatur Memorial Hospital Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Doctors Cancer Center Manatí, | |
| Duluth Clinic Ashland Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Edward Hospital/Cancer Center Naperville, Illinois | |
| Edward Hospital/Cancer Center?Plainfield Plainfield, Illinois | Site Public Contact - (Cancerresearch@edward.org) |
| Edwards Comprehensive Cancer Center Huntington, West Virginia | Site Public Contact - (Christina.Cole@chhi.org) |
| Elmhurst Memorial Hospital Elmhurst, Illinois | Site Public Contact - (Jrohde@emhc.org) |
| Englewood Hospital and Medical Center Englewood, New Jersey | |
| Enloe Medical Center Chico, California | |
| Essentia Health - Baxter Clinic Baxter, Minnesota | |
| Essentia Health - Deer River Clinic Deer River, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Ely Clinic Ely, Minnesota | |
| Essentia Health - Fosston Fosston, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - International Falls Clinic International Falls, Minnesota | |
| Essentia Health - Jamestown Clinic Jamestown, North Dakota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Moose Lake Clinic Moose Lake, Minnesota | |
| Essentia Health - Park Rapids Park Rapids, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center-South University Clinic Fargo, North Dakota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Hibbing Clinic Hibbing, Minnesota | |
| Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Saint Mary's Hospital - Superior Superior, Wisconsin | |
| Essentia Health Saint Mary's Medical Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Sandstone Sandstone, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Virginia Clinic Virginia, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Hayward Clinic Hayward, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Spooner Clinic Spooner, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| FMH James M Stockman Cancer Institute Frederick, Maryland | |
| Fairbanks Memorial Hospital Fairbanks, Alaska | Site Public Contact - (Veronica.Stevenson@foundationhealth.org) |
| Fairfield Medical Center Lancaster, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Lakes Medical Center Wyoming, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Northland Medical Center Princeton, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Southdale Hospital Edina, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Flaget Memorial Hospital Bardstown, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Frederick Memorial Hospital Frederick, Maryland | |
| Frederick Memorial Hospital Crestwood Frederick, Maryland | Site Public Contact - (ctsucontact@westat.com) |
| Freeman Health System Joplin, Missouri | Site Public Contact - (LJCrockett@freemanhealth.com) |
| Freeman Physician Group of Pittsburg Pittsburg, Kansas | Site Public Contact - (BNMathew@freemanhealth.com) |
| Fremont - Rideout Cancer Center Marysville, California | |
| Fresno Cancer Center Fresno, California | Site Public Contact - (Kpoct@kp.org) |
| Garnet Health Medical Center Middletown, New York | Site Public Contact - (jgerlach@garnethealth.org) |
| Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center Danville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Oncology-Selinsgrove Selinsgrove, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Gene Upshaw Memorial Tahoe Forest Cancer Center Truckee, California | |
| Genesee Hematology Oncology PC Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Genesis Healthcare System Cancer Care Center Zanesville, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Genesys Hurley Cancer Institute Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| George Washington University Medical Center Washington D.C., District of Columbia | |
| Gibbs Cancer Center-Gaffney Gaffney, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Gibbs Cancer Center-Pelham Greer, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Glens Falls Hospital Glens Falls, New York | |
| Good Samaritan Hospital - Cincinnati Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Goshen Center for Cancer Care Goshen, Indiana | Site Public Contact - (cccois@goshenhealth.com) |
| Greater Dayton Cancer Center Kettering, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Greater Regional Medical Center Creston, Iowa | Site Public Contact - (cancerresearch@mercydesmoines.org) |
| HSHS Saint Elizabeth's Hospital O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Halifax Health Medical Center-Centers for Oncology Daytona Beach, Florida | |
| Hawaii Cancer Care - Westridge ‘Aiea, Hawaii | Site Public Contact - (info@hawaiicancercare.com) |
| Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii | Site Public Contact - (i.webster@hawaiicancercare.com) |
| Hawaii Diagnostic Radiology Services LLC Honolulu, Hawaii | Site Public Contact - (mmiyoshi@hawaiidrs.com) |
| HaysMed Hays, Kansas | |
| Heartland Regional Medical Center Saint Joseph, Missouri | Site Public Contact - (Trisha.England2@mymlc.com) |
| Hematology Oncology Associates of CNY at Camillus Camillus, New York | |
| Hematology Oncology Associates of Central New York-Auburn Auburn, New York | |
| Hematology Oncology Associates of Central New York-East Syracuse East Syracuse, New York | |
| Hematology Oncology Consultants PC-Royal Oak Royal Oak, Michigan | |
| Hematology Oncology Consultants PC-Troy Troy, Michigan | |
| Hematology Oncology Consultants-Clarkston Clarkston, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Hennepin County Medical Center Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Henry Ford Cancer Institute-Downriver Brownstown, Michigan | |
| Henry Ford Health Saint John Hospital Detroit, Michigan | Site Public Contact - (Kkeenan1@hfhs.org) |
| Henry Ford Health Warren Hospital Warren, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Hospital Detroit, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Madison Heights Hospital - Breast Warren, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Medical Center-Columbus Novi, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford River District Hospital East China Township, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Saint John Hospital - Academic Grosse Pointe Woods, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Saint John Hospital - Breast Grosse Pointe Woods, Michigan | Site Public Contact - (karen.forman@ascension.org) |
| Henry Ford Saint John Hospital - Macomb Medical Macomb, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Saint John Hospital - Van Elslander Grosse Pointe Woods, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Warren Hospital - Breast Macomb Macomb, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford Warren Hospital - GLCMS Warren, Michigan | Site Public Contact - (kforman1@hfhs.org) |
| Henry Ford West Bloomfield Hospital West Bloomfield, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Holy Cross Hospital Fort Lauderdale, Florida | Site Public Contact - (eileen.georgi@holy-cross.com) |
| Hope Cancer Center Pontiac, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Hurley Medical Center Flint, Michigan | Site Public Contact - (wstrong@ghci.org) |
| Huron Gastroenterology PC Ypsilanti, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| IU Health North Hospital Carmel, Indiana | Site Public Contact - (iutrials@iu.edu) |
| Illinois CancerCare - Washington Washington, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Bloomington Bloomington, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Canton Canton, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Carthage Carthage, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Dixon Dixon, Illinois | |
| Illinois CancerCare-Eureka Eureka, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Galesburg Galesburg, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Kewanee Clinic Kewanee, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Macomb Macomb, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Ottawa Clinic Ottawa, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Pekin Pekin, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peoria Peoria, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Peru Peru, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Illinois CancerCare-Princeton Princeton, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana | Site Public Contact - (iutrials@iu.edu) |
| Indu and Raj Soin Medical Center Beavercreek, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Iowa Methodist Medical Center Des Moines, Iowa | |
| Jackson Oncology Associates PLLC Jackson, Mississippi | |
| Jefferson Healthcare Port Townsend, Washington | |
| Jersey Shore Medical Center Neptune City, New Jersey | |
| John Fitzgerald Kennedy Medical Center Atlantis, Florida | |
| John H Stroger Jr Hospital of Cook County Chicago, Illinois | |
| John Muir Medical Center-Walnut Creek Walnut Creek, California | Site Public Contact - (clinicalresearch@johnmuirhealth.com) |
| Kadlec Clinic Hematology and Oncology Kennewick, Washington | Site Public Contact - (research@kadlecmed.org) |
| Kaiser Permanente - Kensington Medical Center Kensington, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente - Largo Medical Center Largo, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente Cancer Treatment Center South San Francisco, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente Downtown Commons Sacramento, California | Site Public Contact - (kpoct@kp.org) |
| Kaiser Permanente Dublin Dublin, California | |
| Kaiser Permanente Lutherville - Timonium Medical Center Lutherville, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente Medical Center - Santa Clara Santa Clara, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii | Site Public Contact - (shelley.a.clark@kp.org) |
| Kaiser Permanente San Leandro San Leandro, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente Tysons Corner Medical Center McLean, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente- Marshall Medical Offices Redwood City, California | |
| Kaiser Permanente-Burke Medical Center Burke, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Capitol Hill Medical Center Washington D.C., District of Columbia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Caton Hill Medical Center Woodbridge, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Fremont Fremont, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Fresno Fresno, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Gaithersburg Medical Center Gaithersburg, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Modesto Modesto, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Oakland Oakland, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Richmond Richmond, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Roseville Roseville, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-San Francisco San Francisco, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Santa Rosa Santa Rosa, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Santa Teresa-San Jose San Jose, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-South Sacramento Sacramento, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-South San Francisco South San Francisco, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Stockton Stockton, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Vallejo Vallejo, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Walnut Creek Walnut Creek, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Woodlawn Medical Center Baltimore, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser San Rafael-Gallinas San Rafael, California | Site Public Contact - (Kpoct@kp.org) |
| Kapiolani Medical Center for Women and Children Honolulu, Hawaii | |
| Katmai Oncology Group Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Kettering Medical Center Kettering, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Knox Community Hospital Mount Vernon, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Kuakini Medical Center Honolulu, Hawaii | |
| Lahey Hospital and Medical Center Burlington, Massachusetts | Site Public Contact - (lhmc-cancer-clinical-trials@lahey.org) |
| Lahey Medical Center-Peabody Peabody, Massachusetts | Site Public Contact - (lhmc-cancer-clinical-trials@lahey.org) |
| Lake Regional Hospital Osage Beach, Missouri | Site Public Contact - (clinicaltrials@lakeregional.com) |
| Lakeview Hospital Stillwater, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Lawrence Memorial Hospital Lawrence, Kansas | Site Public Contact - (Stephanie.Norris@LMH.ORG) |
| Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania | Site Public Contact - (Morgan_M.Horton@lvhn.org) |
| Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania | Site Public Contact - (Morgan_M.Horton@lvhn.org) |
| Lehigh Valley Hospital-Hazleton Hazleton, Pennsylvania | Site Public Contact - (Morgan_M.Horton@lvhn.org) |
| Lexington Medical Center West Columbia, South Carolina | Site Public Contact - (research@lexhhealth.org) |
| Licking Memorial Hospital Newark, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Longmont United Hospital Longmont, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Lyndon Baines Johnson General Hospital Houston, Texas | |
| MU Health Care Goldschmidt Cancer Center Jefferson City, Missouri | |
| Macomb Hematology Oncology PC Warren, Michigan | |
| Marietta Memorial Hospital Marietta, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Marshall Cancer Center Cameron Park, California | Site Public Contact - (cancerservices@marshallmedical.org) |
| Marshfield Medical Center - Minocqua Minocqua, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center - Weston Weston, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-Marshfield Marshfield, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Mary Greeley Medical Center Ames, Iowa | |
| Mayo Clinic Health System-Eau Claire Clinic Eau Claire, Wisconsin | |
| Mayo Clinic Health System-Franciscan Healthcare La Crosse, Wisconsin | |
| Mayo Clinic Health Systems-Mankato Mankato, Minnesota | |
| Mayo Clinic Hospital in Arizona Phoenix, Arizona | |
| Mayo Clinic in Florida Jacksonville, Florida | |
| Mayo Clinic in Rochester Rochester, Minnesota | |
| McFarland Clinic - Ames Ames, Iowa | Site Public Contact - (ksoder@mcfarlandclinic.com) |
| McFarland Clinic - Boone Boone, Iowa | |
| McFarland Clinic - Jefferson Jefferson, Iowa | |
| McFarland Clinic - Marshalltown Marshalltown, Iowa | |
| McFarland Clinic - Trinity Cancer Center Fort Dodge, Iowa | |
| Mease Countryside Hospital Safety Harbor, Florida | Site Public Contact - (research.cto@baycare.org) |
| Medical University of South Carolina Charleston, South Carolina | Site Public Contact - (hcc-clinical-trials@musc.edu) |
| Memorial Hospital Chattanooga, Tennessee | Site Public Contact - (Jeffh@columbusccop.org) |
| Memorial Hospital of Carbondale Carbondale, Illinois | Site Public Contact - (clinical.research@sih.net) |
| Mercy Cancer Center Merced, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Cape Girardeau Cape Girardeau, Missouri | |
| Mercy Cancer Center - Carmichael Carmichael, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Elk Grove Elk Grove, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Rocklin Rocklin, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Sacramento Sacramento, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center-West Lakes Clive, Iowa | Site Public Contact - (cancerresearch@mercydesmoines.org) |
| Mercy Clinic-Rolla-Cancer and Hematology Rolla, Missouri | |
| Mercy Health - Paducah Cancer Center Paducah, Kentucky | Site Public Contact - (BJWarner@mercy.com) |
| Mercy Health - Perrysburg Hospital Perrysburg, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mercy Health - Saint Anne Hospital Toledo, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mercy Health - Saint Vincent Hospital Toledo, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mercy Health Sylvania Radiation Oncology Center Toledo, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mercy Hospital Coon Rapids, Minnesota | |
| Mercy Hospital Coon Rapids, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mercy Hospital Fort Smith Fort Smith, Arkansas | |
| Mercy Hospital Joplin Joplin, Missouri | Site Public Contact - (esmeralda.carrillo@mercy.net) |
| Mercy Hospital Oklahoma City Oklahoma City, Oklahoma | |
| Mercy Hospital Saint Louis St Louis, Missouri | |
| Mercy Hospital South St Louis, Missouri | Site Public Contact - (Danielle.Werle@mercy.net) |
| Mercy Hospital Springfield Springfield, Missouri | |
| Mercy Hospital Washington Washington, Missouri | |
| Mercy Medical Center Springfield, Massachusetts | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Medical Center - Des Moines Des Moines, Iowa | Site Public Contact - (cancerresearch@mercydesmoines.org) |
| Mercy Medical Center-West Lakes West Des Moines, Iowa | Site Public Contact - (cancerresearch@mercydesmoines.org) |
| Mercy San Juan Medical Center Carmichael, California | Site Public Contact - (OncologyResearch@DignityHealth.org) |
| Methodist Medical Center of Illinois Peoria, Illinois | Site Public Contact - (andersonj@illinoiscancercare.com) |
| Michigan Healthcare Professionals Pontiac Pontiac, Michigan | Site Public Contact - (Emily.Crofts@trinity-health.org) |
| Michigan Institute of Urology-Town Center Troy, Michigan | |
| Midlands Community Hospital Papillion, Nebraska | |
| Midwestern Regional Medical Center Zion, Illinois | |
| Miller-Dwan Hospital Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Minnesota Oncology - Burnsville Burnsville, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mission Hope Medical Oncology - Santa Maria Santa Maria, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Missouri Baptist Medical Center St Louis, Missouri | |
| Missouri Baptist Sullivan Hospital Sullivan, Missouri | |
| Monticello Cancer Center Monticello, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Morton Plant Hospital Clearwater, Florida | |
| Mount Carmel East Hospital Columbus, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mount Carmel Grove City Hospital Grove City, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mount Carmel Health Center West Columbus, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mount Carmel New Albany Surgical Hospital New Albany, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Mountain Blue Cancer Care Center - Swedish Englewood, Colorado | |
| Munson Medical Center Traverse City, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| MyMichigan Medical Center Alpena Alpena, Michigan | Site Public Contact - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Gladwin Gladwin, Michigan | Site Public Contact - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Gratiot Alma, Michigan | Site Public Contact - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Midland Midland, Michigan | Site Public Contact - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Mount Pleasant Mount Pleasant, Michigan | Site Public Contact - (CVResearch@mymichigan.org) |
| MyMichigan Medical Center Saginaw Saginaw, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| MyMichigan Medical Center Tawas Tawas City, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| New Ulm Medical Center New Ulm, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Newark Radiation Oncology Newark, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Newland Medical Associates-Clarkston Clarkston, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Newland Medical Associates-Pontiac Pontiac, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| North Grove Medical Park Spartanburg, South Carolina | |
| North Memorial Medical Health Center Robbinsdale, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| North Shore Medical Center Skokie, Illinois | Site Public Contact - (Roster@nrgoncology.org) |
| NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois | |
| NorthShore University HealthSystem-Glenbrook Hospital Glenview, Illinois | |
| NorthShore University HealthSystem-Highland Park Hospital Highland Park, Illinois | |
| Northwest Medical Specialties PLLC Tacoma, Washington | Site Public Contact - (research@southsoundcare.org) |
| Northwest Wisconsin Cancer Center Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Northwestern Medicine Cancer Center Delnor Geneva, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Cancer Center Kishwaukee DeKalb, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern Medicine Glenview Outpatient Center Glenview, Illinois | |
| Northwestern Medicine Grayslake Outpatient Center Grayslake, Illinois | |
| Northwestern Medicine Lake Forest Hospital Lake Forest, Illinois | Site Public Contact - (cancertrials@northwestern.edu) |
| Northwestern Medicine Orland Park Orland Park, Illinois | Site Public Contact - (nctnprogram_rhlccc@northwestern.edu) |
| Northwestern University Chicago, Illinois | Site Public Contact - (cancer@northwestern.edu) |
| OSF Saint Anthony's Health Center Alton, Illinois | |
| Oakland Colon Rectal Associates Royal Oak, Michigan | |
| Oakland Medical Group Royal Oak, Michigan | |
| Ohio State University Comprehensive Cancer Center Columbus, Ohio | Site Public Contact - (Jamesline@osumc.edu) |
| Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa | |
| Oncology Hematology Associates of Saginaw Valley PC Saginaw, Michigan | |
| Oncology Hematology Care Inc-Kenwood Cincinnati, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Orion Cancer Care Findlay, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| PROncology San Juan, | Site Public Contact - (info@PRoncology.com) |
| Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Pali Momi Medical Center ‘Aiea, Hawaii | |
| Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Parkland Health Center - Farmington Farmington, Missouri | |
| PeaceHealth Saint John Medical Center Longview, Washington | Site Public Contact - (kmakin-bond@peacehealth.org) |
| PeaceHealth Saint Joseph Medical Center Bellingham, Washington | |
| PeaceHealth United General Medical Center Sedro-Woolley, Washington | Site Public Contact - (rcrompton@peacehealth.org) |
| Penn State Milton S Hershey Medical Center Hershey, Pennsylvania | Site Public Contact - (CTO@hmc.psu.edu) |
| Penrose-Saint Francis Healthcare Colorado Springs, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Phelps Health Delbert Day Cancer Institute Rolla, Missouri | Site Public Contact - (research@phelpshealth.org) |
| Phoenixville Hospital Phoenixville, Pennsylvania | |
| Physicians' Clinic of Iowa PC Cedar Rapids, Iowa | |
| Pocono Medical Center East Stroudsburg, Pennsylvania | Site Public Contact - (Morgan_M.Horton@lvhn.org) |
| Premier Hematology Oncology Care Sterling Heights, Michigan | |
| Presbyterian - Saint Lukes Medical Center - Health One Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Providence Alaska Medical Center Anchorage, Alaska | Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org) |
| Providence Cancer Institute Clackamas Clinic Clackamas, Oregon | |
| Providence Medical Foundation - Santa Rosa Santa Rosa, California | |
| Providence Newberg Medical Center Newberg, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Providence Portland Medical Center Portland, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Providence Queen of The Valley Napa, California | |
| Providence Regional Cancer Partnership Everett, Washington | Site Public Contact - (marilyn.birchman@providence.org) |
| Providence Regional Cancer System-Aberdeen Aberdeen, Washington | Site Public Contact - (deidre.dillon@providence.org) |
| Providence Regional Cancer System-Centralia Centralia, Washington | Site Public Contact - (deidre.dillon@providence.org) |
| Providence Regional Cancer System-Lacey Lacey, Washington | Site Public Contact - (deidre.dillon@providence.org) |
| Providence Regional Cancer System-Shelton Shelton, Washington | |
| Providence Regional Cancer System-Yelm Yelm, Washington | |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank, California | Site Public Contact - (Najee.Boucher@providence.org) |
| Providence Saint Mary Regional Cancer Center Walla Walla, Washington | Site Public Contact - (Cheryl.Dodd@providence.org) |
| Providence Saint Vincent Medical Center Portland, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Providence Santa Rosa Memorial Hospital Santa Rosa, California | |
| Providence Willamette Falls Medical Center Oregon City, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Puerto Rico Hematology Oncology Group Bayamón, | |
| Queen's Cancer Cenrer - POB I Honolulu, Hawaii | |
| Queen's Cancer Center - Kuakini Honolulu, Hawaii | |
| Queen's Cancer Center - Pearlridge ‘Aiea, Hawaii | |
| Queen's Medical Center Honolulu, Hawaii | |
| Rapid City Regional Hospital Rapid City, South Dakota | Site Public Contact - (research@monument.health) |
| Reading Hospital West Reading, Pennsylvania | |
| Redeemer Health Meadowbrook, Pennsylvania | |
| Regional Cancer Center-Lee Memorial Health System Fort Myers, Florida | Site Public Contact - (Roster@nrgoncology.org) |
| Regions Hospital Saint Paul, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Reid Health Richmond, Indiana | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Rice Memorial Hospital Willmar, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Ridgeview Medical Center Waconia, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Riverwood Healthcare Center Aitkin, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Rocky Mountain Cancer Centers - Centennial Centennial, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers - Swedish Englewood, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Aurora Aurora, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Boulder Boulder, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Lakewood Lakewood, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Littleton Littleton, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Longmont Longmont, Colorado | Site Public Contact - (ResearchTracking@Centura.Org) |
| Rocky Mountain Cancer Centers-Midtown Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Penrose Colorado Springs, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Rocky Mountain Cancer Centers-Rose Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Thornton Thornton, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rohnert Park Cancer Center Rohnert Park, California | Site Public Contact - (Kpoct@kp.org) |
| Rush - Copley Medical Center Aurora, Illinois | Site Public Contact - (Cancer.Research@rushcopley.com) |
| Rush-Copley Healthcare Center Yorkville, Illinois | Site Public Contact - (Cancer.Research@rushcopley.com) |
| SIH Cancer Institute Carterville, Illinois | Site Public Contact - (clinical.research@sih.net) |
| SMC Center for Hematology Oncology Union Union, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| SSM Health Good Samaritan Mount Vernon, Illinois | Site Public Contact - (gayla.hall@ssmhealth.com) |
| Saint Ann's Hospital Westerville, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Saint Anthony Hospital Lakewood, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Anthony North Hospital Westminster, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Anthony Regional Hospital Carroll, Iowa | Site Public Contact - (sbenson@iora.org) |
| Saint Anthony's Hospital Cancer Care Center St. Petersburg, Florida | Site Public Contact - (Research.CTO@baycare.org) |
| Saint Charles Health System Bend, Oregon | Site Public Contact - (nosall@stcharleshealthcare.org) |
| Saint Charles Health System-Redmond Redmond, Oregon | |
| Saint Claire Regional Medical Center Morehead, Kentucky | |
| Saint Elizabeth Boardman Hospital Boardman, Ohio | |
| Saint Elizabeth Regional Medical Center Lincoln, Nebraska | |
| Saint Elizabeth Youngstown Hospital Youngstown, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Saint Francis Cancer Center Greenville, South Carolina | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Francis Medical Center Cape Girardeau, Missouri | Site Public Contact - (sfmc@sfmc.net) |
| Saint Francis Regional Medical Center Shakopee, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Saint John's Cancer Institute Santa Monica, California | |
| Saint John's Hospital - Healtheast Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Saint Joseph Hospital Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Hospital Lexington, Kentucky | Site Public Contact - (carcieri@sjh-nh.org) |
| Saint Joseph Hospital East Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph London London, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Mount Sterling Mount Sterling, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Radiation Oncology Resource Center Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Warren Hospital Warren, Ohio | |
| Saint Joseph's Hospital/Children's Hospital-Tampa Tampa, Florida | Site Public Contact - (jennifer.manns@baycare.org) |
| Saint Joseph's Medical Center Stockton, California | |
| Saint Louis Cancer and Breast Institute-Ballwin Ballwin, Missouri | |
| Saint Louis Cancer and Breast Institute-South City St Louis, Missouri | |
| Saint Luke's Cancer Institute - Boise Boise, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Fruitland Fruitland, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Meridian Meridian, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Nampa Nampa, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Luke's Cancer Institute - Twin Falls Twin Falls, Idaho | Site Public Contact - (eslinget@slhs.org) |
| Saint Mary Corwin Medical Center Pueblo, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Mary's Hospital Centralia, Illinois | Site Public Contact - (Roster@nrgoncology.org) |
| Saint Mary's Oncology/Hematology Associates of Marlette Marlette, Michigan | |
| Saint Mary's Oncology/Hematology Associates of West Branch West Branch, Michigan | |
| Saint Michael Cancer Center Silverdale, Washington | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Patrick Hospital - Community Hospital Missoula, Montana | Site Public Contact - (amy.hanneman@providence.org) |
| Saint Rita's Medical Center Lima, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri | |
| Salem Hospital Salem, Oregon | |
| Salina Regional Health Center Salina, Kansas | Site Public Contact - (mleepers@srhc.com) |
| San Juan City Hospital San Juan, | |
| San Juan Community Oncology Group San Juan, | |
| Shenandoah Oncology PC Winchester, Virginia | Site Public Contact - (William.Houck@usoncology.com) |
| Skagit Regional Health Cancer Care Center Mount Vernon, Washington | Site Public Contact - (rcccclinicalresearch@skagitvalleyhospital.org) |
| South Florida Baptist Hospital Plant City, Florida | Site Public Contact - (Claudia.Quinones@baycare.org) |
| South Sacramento Cancer Center Sacramento, California | Site Public Contact - (Kpoct@kp.org) |
| Southern Illinois University School of Medicine Springfield, Illinois | |
| Southern Ocean County Medical Center Manahawkin, New Jersey | |
| Southern Ohio Medical Center Portsmouth, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Southwest Oncology PC Durango, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Spartanburg Medical Center Spartanburg, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Spartanburg Medical Center - Mary Black Campus Spartanburg, South Carolina | |
| Springfield Clinic Springfield, Illinois | |
| Springfield Memorial Hospital Springfield, Illinois | Site Public Contact - (pallante.beth@mhsil.com) |
| Springfield Regional Cancer Center Springfield, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Springfield Regional Medical Center Springfield, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Stony Brook University Medical Center Stony Brook, New York | |
| Straub Clinic and Hospital Honolulu, Hawaii | |
| Straub Pearlridge Clinic ‘Aiea, Hawaii | |
| Strecker Cancer Center-Belpre Belpre, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| Summit Health - Florham Park Campus Florham Park, New Jersey | Site Public Contact - (mmackenzie@summithealth.com) |
| Summit Medical Group Berkeley Heights, New Jersey | Site Public Contact - (Roster@nrgoncology.org) |
| Swedish Cancer Institute-Edmonds Edmonds, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Swedish Cancer Institute-Issaquah Issaquah, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Swedish Covenant Hospital Chicago, Illinois | |
| Swedish Medical Center-Ballard Campus Seattle, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Swedish Medical Center-Cherry Hill Seattle, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Swedish Medical Center-First Hill Seattle, Washington | Site Public Contact - (PCRC-NCORP@Swedish.org) |
| Tallahassee Memorial HealthCare Tallahassee, Florida | |
| The Cancer Center of Hawaii-Liliha Honolulu, Hawaii | |
| The Cancer Center of Hawaii-Pali Momi ‘Aiea, Hawaii | |
| The Don and Sybil Harrington Cancer Center Amarillo, Texas | Site Public Contact - (Gina.Cravey@bsahs.org) |
| The Mark H Zangmeister Center Columbus, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
| The Melanoma and Skin Cancer Institute Englewood, Colorado | Site Public Contact - (ryan.weight@theskincancerinstitute.com) |
| The Permanente Medical Group-Roseville Radiation Oncology Roseville, California | Site Public Contact - (Kpoct@kp.org) |
| The Queen's Medical Center - West Oahu ‘Ewa Beach, Hawaii | Site Public Contact - (rohta@queens.org) |
| The University of Kansas Cancer Center - Olathe Olathe, Kansas | Site Public Contact - (atheCCResearch@kumc.edu) |
| The Women's Imaging Center Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| ThedaCare Cancer Care - Oshkosh Oshkosh, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| ThedaCare Cancer Care - Shawano Shawano, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| ThedaCare Cancer Care - Waupaca Waupaca, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| ThedaCare Regional Cancer Center Appleton, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| ThedaCare Regional Medical Center - Neenah Neenah, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| Tidelands Georgetown Memorial Hospital Georgetown, South Carolina | Site Public Contact - (broe@tidelandshealth.org) |
| Torrance Memorial Medical Center Torrance, California | |
| Torrance Memorial Physician Network - Cancer Care Torrance, California | Site Public Contact - (courtney.steeneken@tmphysicians.com) |
| TriHealth Cancer Institute-Anderson Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| TriHealth Cancer Institute-Westside Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Trinity Health Grand Rapids Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology - Canton Canton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Medical Center - Brighton Brighton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Medical Center - Canton Canton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Muskegon Hospital Muskegon, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Medical Center Moline, Illinois | |
| Trinity Regional Medical Center Fort Dodge, Iowa | |
| Tufts Medical Center Boston, Massachusetts | Site Public Contact - (ContactUsCancerCenter@TuftsMedicalCenter.org) |
| Tufts Medical Center Cancer Center Stoneham Stoneham, Massachusetts | Site Public Contact - (NCCCR@Tuftsmedicalcenter.org) |
| UCLA / Jonsson Comprehensive Cancer Center Los Angeles, California | |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny, Iowa | |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines, Iowa | |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines, Iowa | |
| UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee, Iowa | |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa | |
| UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie, Maryland | |
| UP Health System Hematology Oncology Marquette Marquette, Michigan | Site Public Contact - (Dianna.Larson@mghs.org) |
| UP Health System Marquette Marquette, Michigan | Site Public Contact - (Dianna.Larson@mghs.org) |
| UPMC Cancer Center at UPMC Horizon Farrell, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg, Pennsylvania | |
| UPMC Hillman Cancer Center - Monroeville Monroeville, Pennsylvania | Site Public Contact - (haneydl@upmc.edu) |
| UPMC Hillman Cancer Center - Passavant - Cranberry Cranberry Township, Pennsylvania | Site Public Contact - (haneydl@upmc.edu) |
| UPMC Hillman Cancer Center Erie Erie, Pennsylvania | Site Public Contact - (haneydl@upmc.edu) |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg, Pennsylvania | Site Public Contact - (haneydl@upmc.edu) |
| UPMC Memorial York, Pennsylvania | |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg, Pennsylvania | Site Public Contact - (klitchfield@PINNACLEHEALTH.org) |
| UPMC Western Maryland Cumberland, Maryland | |
| UPMC-Magee Womens Hospital Pittsburgh, Pennsylvania | |
| UPMC-Passavant Hospital Pittsburgh, Pennsylvania | |
| UPMC-Saint Clair Hospital Cancer Center Pittsburgh, Pennsylvania | |
| UTMB Cancer Center at Victory Lakes League City, Texas | |
| UTMB Health Angleton Danbury Campus Angleton, Texas | Site Public Contact - (vsklimbe@utmb.edu) |
| United Hospital Saint Paul, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| University Health Truman Medical Center Kansas City, Missouri | |
| University of Cincinnati Cancer Center-UC Medical Center Cincinnati, Ohio | Site Public Contact - (cancer@uchealth.com) |
| University of Cincinnati Cancer Center-West Chester West Chester, Ohio | Site Public Contact - (cancer@uchealth.com) |
| University of Hawaii Cancer Center Honolulu, Hawaii | |
| University of Iowa Healthcare Cancer Services Quad Cities Bettendorf, Iowa | Site Public Contact - (katherine-daprile@uiowa.edu) |
| University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa | |
| University of Kansas Cancer Center Kansas City, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center - Lee's Summit Lee's Summit, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center - North Kansas City, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center at North Kansas City Hospital North Kansas City, Missouri | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center-Overland Park Overland Park, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Health System Saint Francis Campus Topeka, Kansas | |
| University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Michigan Health - Sparrow Lansing Lansing, Michigan | Site Public Contact - (harsha.trivedi@umhsparrow.org) |
| University of Michigan Health - West Wyoming, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma | Site Public Contact - (ou-clinical-trials@ouhsc.edu) |
| University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania | |
| University of Texas Medical Branch Galveston, Texas | Site Public Contact - (clinical.research@utmb.edu) |
| VCU Community Memorial Health Center South Hill, Virginia | Site Public Contact - (nemer.elmouallem@vcuhealth.org) |
| VCU Massey Cancer Center at Stony Point Richmond, Virginia | Site Public Contact - (ctoclinops@vcu.edu) |
| Valley Radiation Oncology Peru, Illinois | |
| Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| Washington Hospital Fremont, California | |
| Wayne Hospital Greenville, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| West Michigan Cancer Center Kalamazoo, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| West Suburban Medical Center River Forest, Illinois | |
| Western Illinois Cancer Treatment Center Galesburg, Illinois | |
| Wilcox Memorial Hospital and Kauai Medical Clinic Lihue, Hawaii | |
| Winter Haven Hospital Winter Haven, Florida | Site Public Contact - (Research.CTO@baycare.org) |
| Woodland Memorial Hospital Woodland, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Wright-Patterson Medical Center Wright-Patterson Air Force Base, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Zangmeister Center Grove City Grove City, Ohio | Site Public Contact - (Jeffh@columbusccop.org) |
Cryospray Therapy Versus Standard of Care for Benign Airway Stenosis (CryoStasis)
Ankush Ratwani, MD - ankush.ratwani@vumc.org
NCT04996173
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
• Referral to interventional pulmonology or ENT for endoscopic management of suspected benign tracheal stenosis.
• Significant tracheal stenosis defined by stenosis ≥ 50% of tracheal lumen assessed on chest CT or symptomatology warranting evaluation.
• Able to provide informed consent
• Age \> 18
Exclusion Criteria:
• Inability to provide informed consent.
• Pregnancy
• Known or suspected malignant central airway stenosis
• Patient has already been enrolled in this study.
• Study subject has any disease or condition that interferes with safe completion of the study including:
• Hypoxemia with need for supplemental oxygen ≥ 2L/min by nasal canula
• Recent pneumothorax in the previous 12 months
• Severe COPD (defined as a FEV1/FVC \< 70% and FEV1 \< 30% predicted) and/or severe persistent asthma.
• Hemodynamic instability with systolic blood pressure \<90 mmHg or heart rate \> 120 beats/min, unless deemed to be stable with these values by the attending physicians.
• Prior complications with SCT
• Contraindication to rigid bronchoscopy
• Significant tracheomalacia or alterations in cartilage integrity that would require stent placement or surgical referral as assessed by CT imaging.
• Greater then 1 BCAS intervention within 6 months before enrollment
DEVICE: Spray cryotherapy, DEVICE: Ballon Dilation, DEVICE: Radial Incision
Pulmonary Disease
I'm interested
Share via email
Show 3 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| University of Mississippi Medical Center Jackson, Mississippi | Stacy Porter - (sporter6@umc.edu) |
| Vanderbilt University Medical Center Nashville, Tennessee | Brianna Swanner - (briana.swanner@vumc.org) |
| Virginia Commonwealth University Richmond, Virginia | Ramsha Hamid - (ramsha.hamid@vcuhealth.org) |
Advancing Water Security: A Community Participatory School-Based Hydration Intervention
Sarah Farthing, MS - sarah.malone@vcuhealth.org
Melanie Bean
NCT06714929
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Lunchroom observations: All students (K-5th \[Pre-Kindergarten if applicable\]) who eat lunch in the cafeteria on assessment days are eligible
* BMI and dental caries assessments: 1) student enrolls in study while in 3rd grade (followed through 5th g)
* Student surveys: Students in 4th-5th grade are eligible to complete surveys assessing beverage intake and perceptions of hydration practices within their school district.
* Staff surveys: All staff in the target schools will be eligible to complete the Personnel Survey.
Exclusion Criteria:
* Lunchroom observations: None.
* BMI and dental caries assessments: Students are ineligible if they are unable to complete assessments due to developmental or physical reasons, 2) planning to move in the study duration
* Student surveys: None.
* Staff surveys: None. BEHAVIORAL: Hydration
Dental Caries, Obesity Prevention
hydration, water, sugar-sweetened beverages, dental caries, overweight and obesity
I'm interested
Share via email
Show 1 location
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Children's Hospital of Richmond at VCU Healthy Lifestyles Center Henrico, Virginia | Sarah M Farthing, MS - (sarah.malone@vcuhealth.org) Melanie K Bean, PhD - (melanie.bean@vcuhealth.org) |
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy (REBIRTH)
Dennis McNamara, MD - mcnamaradm@upmc.edu
NCT05180773
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
• Presentation with a new diagnosis of peripartum cardiomyopathy
• Post-delivery and within the first 5 months post-partum.
• Clinical assessment of an LVEF \< or =0.40 within 4 weeks of consent for randomized control trial
• Clinical assessment of an LVEF \< or =0.40 within 8 weeks of consent for breastfeeding cohort
• Age \> or = 18.
Exclusion Criteria:
• Previous diagnosis of cardiomyopathy, valvular disease or congenital heart disease (with the exception of women with a history of peripartum cardiomyopathy with complete recovery and a documented LVEF \> 0.55 prior to or in early pregnancy)
• Refractory hypertension (Systolic \>160 or Diastolic \> 95) either at the time of enrollment or at the time of the qualifying LVEF.
• Postpartum women currently breastfeeding and planning to continue.
• Evidence of coronary artery disease (\>50% stenosis of major epicardial vessel or positive non-invasive stress test)
• Previous cardiac transplant
• Current durable LVAD support
• Currently requiring support with extracorporeal membrane oxygenation (ECMO)
• Current history of alcohol or drug abuse
• Chemotherapy or chest radiation within 5 years of enrollment
• Evidence of ongoing bacterial septicemia
• Medical, social or psychiatric condition which limit the ability to comply with follow-up.
DRUG: Bromocriptine, DRUG: Placebo, DRUG: Guideline Directed Medical Therapy for Heart Failure (GDMT), DRUG: Rivaroxaban, DRUG: Second Placebo
Peripartum Cardiomyopathy, Postpartum
I'm interested
Share via email
Show 64 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Albert Einstein College of Medicine/ Montefiore Medical Center The Bronx, New York | Vanya Prasad - (vprasad@montefiore.org) |
| Ascension St. Vincent Heart Center Indianapolis, Indiana | Anne Renick - (anne.renick@ascension.org) Regina Margiotti - (RAMARGIO@ascension.org) |
| Atrium Health Sanger Heart and Vascular Institute Charlotte, North Carolina | Zaida Roman - (Zaida.roman@atriumhealth.org) |
| Baylor College of Medicine Houston, Texas | Sandra Pena - (sandra.pena@bcm.edu) |
| Brigham and Women's Hospital Boston, Massachusetts | Audrey Yun - (ayun1@bwh.harvard.edu) Mariam Markabani - (mmarkabani@bwh.harvard.edu) |
| Cedars-Sinai Medical Center Los Angeles, California | Odette Chida Ibarra - (odette.chidaibarra@cshs.org) |
| Cleveland Clinic Cleveland, Ohio | Barbara Gus - (gusb@ccf.org) |
| Columbia University Irving Medical Center New York, New York | Barbara Alvarez - (bsa2133@cumc.columbia.edu) |
| Emory University Atlanta, Georgia | Eisha Udeshi - (eudeshi@emory.edu) Nino Kavtaradze - (nkavtar@emory.edu) |
| Hartford Hospital Hartford, Connecticut | Khadija El Aoudi - (Khadija.ElAoudi@hhchealth.org) |
| Henry Ford Health System Detroit, Michigan | Jodi Carter - (jcarte23@hfhs.org) |
| Indiana University/Indiana University Health Indianapolis, Indiana | Srdjan Kurbalija - (skurbalija@iuhealth.org) |
| Inova Healthcare Services Fairfax, Virginia | Joanne Wotring - (joanne.wotring@inova.org) |
| Intermountain Medical Center Murray, Utah | Morgan McClure - (morgan.mcclure@imail.org) |
| Johns Hopkins University Baltimore, Maryland | Yavette Goldsborough - (ygoldsb1@jhmi.edu) |
| Karen L Florio, MD Columbia, Missouri | Akira Clemons - (amcg5z@umsystem.edu) |
| Keck School of Medicine of USC Los Angeles, California | Jorge Caro - (jorge.caro@med.usc.edu) |
| Lehigh Valley Health Network Allentown, Pennsylvania | |
| Louisiana State University Shreveport, Louisiana | Monicah Jepkemboi - (monicah.jepkemboi@lsuhs.edu) |
| Massachusetts General Hospital Boston, Massachusetts | Monica Duan - (mduan2@mgb.org) |
| Mayo Clinic, Florida Jacksonville, Florida | Jena Hayes - (hayes.jena@mayo.edu) |
| Mayo Clinic, Rochester Rochester, Minnesota | Molly Dolan - (Dolan.Molly@mayo.edu) Brittni Ferdinand - (Ferdinand.brittni@mayo.edu) |
| Medical College of Wisconsin Milwaukee, Wisconsin | Amy Blair - (ablair@mcw.edu) |
| Medical University of South Carolina Charleston, South Carolina | Virginia Theodorof - (theodoro@musc.edu) Olivia Washington - (washoliv@musc.edu) |
| Minneapolis Heart Institute Foundation Minneapolis, Minnesota | Sarah Schwager - (Sarah.Schwager@allina.com) Gretchen Benson - (GBenson@mhif.org) |
| Mount Sinai Hospital New York, New York | Lovelyne Julien - (lovelyn.julien@mountsinai.org) Tiffany Soto - (tiffany.soto@mssm.edu) |
| NYU Langone Health New York, New York | Lucia Muzzarelli - (Lucia.Muzzarelli@nyulangone.org) |
| Northwestern University Chicago, Illinois | Jessica Patalino - (jessica.patalino@nm.org) |
| Oklahoma University Health Science Center Oklahoma City, Oklahoma | Natalie Feland - (natalie-feland@ouhsc.edu) |
| Old Dominion University Norfolk, Virginia | Kristin Ayers - (ayerskl@evms.edu) |
| Penn State Hershey Medical Center Hershey, Pennsylvania | Katie Loffredo - (kloffredo@pennstatehealth.psu.edu) Veronica Bausher - (vbausher@pennstatehealth.psu.edu) |
| Rhode Island Hospital Providence, Rhode Island | Kelly Franchetti, RN - (kfranchetti@lifespan.org) |
| Saint Luke's Hospital of Kansas City Kansas City, Missouri | Rosann Gans, RN - (rgans@saint-lukes.org) |
| Stanford University Stanford, California | Tamara Bazouzi - (bazouzit@stanford.edu) |
| Stern Cardiovascular Foundation, Inc Germantown, Tennessee | Denise Peeler - (denise.peeler@sterncardio.com) Kari Fondren - (kari.fondren@sterncardio.com) |
| Stony Brook Medicine Stony Brook, New York | Uzma Usmani - (Uzma.Usmani@stonybrookmedicine.edu) |
| Temple Heart and Vascular Institute Philadelphia, Pennsylvania | Jennie Wong - (jennie.wong@tuhs.temple.edu) |
| UT Southern Medical Center Dallas, Texas | |
| University Hospitals, Cleveland Medical Center Cleveland, Ohio | Emily Mullenax - (Emily.Mullenax@UHhospitals.org) |
| University of Alabama Birmingham Birmingham, Alabama | LaTangellia Walker - (latangelliadwalker@uabmc.edu) Nancy Saxon - (nbsaxon@uabmc.edu) |
| University of Arizona Sarver Heart Center Tucson, Arizona | Lizzette Cruz - (marquez@shc.arizona.edu) |
| University of California Irvine Health Orange, California | Linh Huỳnh, MPH - (plhuynh@hs.uci.edu) |
| University of California San Diego La Jolla, California | Rachel Han - (rah015@health.ucsd.edu) |
| University of Colorado Anschutz Medical Campus Aurora, Colorado | Jamie Demmitt, BA - (jamie.demmitt@cuanschutz.edu) |
| University of Florida Gainesville, Florida | David Solares - (David.Solares@medicine.ufl.edu) Vanessa Holway Scheuble - (Vanessa.Scheuble@medicine.ufl.edu) |
| University of Illinois Health Heart Center Chicago, Illinois | Muriel Chen - (yining@uic.edu) |
| University of Iowa Hospitals and Clinic Iowa City, Iowa | Cynthia Larew - (cynthia-larew@uiowa.edu) Page Scovel - (page-scovel@uiowa.edu) |
| University of Kentucky, Gill Heart & Vascular Institute Lexington, Kentucky | Jennifer Isaacs - (Jennifer.isaacs@uky.edu) Travis Sexton - (trsext2@uky.edu) |
| University of Maryland Medical Center, Baltimore Baltimore, Maryland | Caitlin Hearn - (chearn@som.umaryland.edu) |
| University of Michigan Ann Arbor, Michigan | Kavita Shah - (skavita@med.umich.edu) |
| University of Minnesota Minneapolis, Minnesota | Melanie Farinella - (crawl027@umn.edu) |
| University of Pennsylvania Philadelphia, Pennsylvania | Alavi Hossain - (Alavi.Hossain@Pennmedicine.upenn.edu) |
| University of Pittsburgh Medical Center Pittsburgh, Pennsylvania | Dennis McNamara, MD - (mcnamaradm@upmc.edu) Donna Simpson, CRNP, MPH - (simpsondm@upmc.edu) |
| University of Rochester Rochester, New York | Lori Caufield, RN BSN CCRC - (lori_caufield@urmc.rochester.edu) |
| University of South Florida Tampa, Florida | Amanda McNamara - (alett1@usf.edu) Jacky He - (jackyhe@usf.edu) |
| University of Texas Health San Antonio San Antonio, Texas | |
| University of Vermont Medical Center Burlington, Vermont | Meghan Sesera, RN - (meghan.sesera@uvmhealth.org) Michaelanne Rowen - (Michaelanne.Rowen@uvmhealth.org) |
| University of Virginia Charlottesville, Virginia | Melanie Dean - (DMD4PD@uvahealth.org) Caroline Flournoy - (clf4w@uvahealth.org) |
| University of Washington Medical Center Seattle, Washington | Adele Stefanowicz - (amstef99@cardiology.washington.edu) |
| University of Wisconsin Madison Madison, Wisconsin | Holly Hage - (hhage@wisc.edu) Karen Olson - (kjolson@medicine.wisc.edu) |
| Vanderbilt Nashville, Tennessee | Olivia Patridge - (olivia.h.patridge@vumc.org) |
| Virginia Commonwealth University Richmond, Virginia | Melissa Sears - (melissa.sears@vcuhealth.org) |
| Washington University School of Medicine St Louis, Missouri | Annie Dirks - (aplatts@wustl.edu) Lesley Alexander - (alesley@wustl.edu) |
| Yale University New Haven, Connecticut | Cinthia S De Freitas - (cinthia.defreitas@yale.edu) |
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps (FORTE)
Director, Department of Regulatory Affairs - langerj@nrgoncology.org
NCT05080673
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* The participant must have signed and dated an IRB-approved consent form that conforms to federal and institutional guidelines.
* Participants greater than or equal to 45 and less than 70 years of age at the time of colonoscopy.
* Participants with a first-time diagnosis of 1-2 non-advanced tubular adenomas (less than 10 mm without tubulovillous or villous changes or high grade or severe dysplasia) from the qualifying colonoscopy within 4 years prior to randomization.
* Sessile serrated polyps/adenomas, as long as they do not meet the criteria for advanced adenomas, will be considered as non-advanced adenomas.
* Qualifying colonoscopy must be a complete colonoscopy with visualization of the cecum and with adequate cleansing within 4 years prior to randomization.
* Complete excision of all observed polyps in qualifying colonoscopy
* Participants must be able to read or understand English or Spanish.
Exclusion Criteria:
* • Prior history of colorectal cancer or colorectal adenomas including sessile serrated polyps/adenomas excluding those found on the qualifying colonoscopy.
* Prior history of a hyperplastic polyp measuring greater than or equal to 1 cm in size.
* Traditional serrated adenomas found on the qualifying colonoscopy.
* Hyperplastic polyp measuring greater than or equal to 1 cm in size found on the qualifying colonoscopy.
* Previous malignancies unless the patient has been disease-free for 5 or more years prior to randomization and is deemed by the physician to be at low risk for recurrence. Patients with the following cancers are eligible if diagnosed and treated within the past 5 years: all in situ cancers and basal cell and squamous cell carcinoma of the skin.
* Colonoscopy performed after the qualifying colonoscopy but prior to randomization.
* Incomplete qualifying colonoscopy (e.g., cecum not visualized).
* Incomplete endoscopic excision of adenomatous polyps based on colonoscopist impression at qualifying colonoscopy. (Excision of all hyperplastic rectosigmoid polyps is not required.)
* Sub-total colectomy or total proctocolectomy. (Segmental resections are allowed.)
* Family history of CRC diagnosed at less than or equal to 60 years of age in a first degree relative (mother, father, child, sibling) or in two first degree relatives with CRC at any age.
* Participants with a clinical diagnosis of a significant heritable risk for colorectal cancer (Familial Adenomatous Polyposis, Hereditary Nonpolyposis Colorectal Cancer \[Lynch Syndrome\]).
* Participants tested positive for a Familial Adenomatous Polyposis, Hereditary Nonpolyposis Colorectal Cancer \[Lynch Syndrome\] genetic mutation that increases risk of colorectal cancer.
* Inflammatory bowel disease (e.g., Crohn's Disease, ulcerative colitis).
* Life expectancy less than 10 years due to comorbid conditions in the opinion of the investigator.
* Other comorbid conditions that would prevent the participant from having colonoscopies or would prevent required follow-up. PROCEDURE: 5-year and 10 Year Surveillance Colonoscopy after Qualifying Colonoscopy
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
I'm interested
Share via email
Show 466 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Abbott-Northwestern Hospital Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| AdventHealth Littleton Littleton, Colorado | |
| AdventHealth Parker Parker, Colorado | |
| AdventHealth Porter Denver, Colorado | |
| Alegent Health Bergan Mercy Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Immanuel Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Lakeside Hospital Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Alegent Health Mercy Hospital Council Bluffs, Iowa | |
| Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Alta Bates Summit Medical Center - Summit Campus Oakland, California | |
| Altru Cancer Center Grand Forks, North Dakota | |
| Ann M Wierman MD LTD Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Armes Family Cancer Center Findlay, Ohio | |
| Ascension All Saints Hospital Racine, Wisconsin | Site Public Contact - (AWRI.Inquiry@Ascension.org) |
| Ascension Calumet Hospital Chilton, Wisconsin | Site Public Contact - (AWRI.inquiry@ascension.org) |
| Ascension Columbia Saint Mary's Hospital - Milwaukee Milwaukee, Wisconsin | Site Public Contact - (AWRI.Inquiry@Ascension.org) |
| Ascension Columbia Saint Mary's Hospital Ozaukee Mequon, Wisconsin | Site Public Contact - (AWRI.Inquiry@Ascension.org) |
| Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa, Wisconsin | Site Public Contact - (AWRI.Inquiry@Ascension.org) |
| Ascension Mercy Hospital Oshkosh, Wisconsin | Site Public Contact - (AWRI.inquiry@ascension.org) |
| Ascension Saint Elizabeth Hospital Appleton, Wisconsin | Site Public Contact - (AWRI.inquiry@ascension.org) |
| Ascension Saint Francis - Reiman Cancer Center Franklin, Wisconsin | Site Public Contact - (AWRI.Inquiry@Ascension.org) |
| Ascension Saint Francis Hospital Milwaukee, Wisconsin | Site Public Contact - (AWRI.Inquiry@Ascension.org) |
| Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield, Wisconsin | Site Public Contact - (AWRI.Inquiry@Ascension.org) |
| Ascension Southeast Wisconsin Hospital - Franklin Franklin, Wisconsin | Site Public Contact - (AWRI.Inquiry@Ascension.org) |
| Ascension Southeast Wisconsin Hospital - Saint Joseph Campus Milwaukee, Wisconsin | Site Public Contact - (AWRI.Inquiry@Ascension.org) |
| Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Augusta University Medical Center Augusta, Georgia | Site Public Contact - (ga_cares@augusta.edu) |
| BASS Medical Group - Lennon Walnut Creek, California | Site Public Contact - (brenna.lindsey@bassmedicalgroup.com) |
| Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee | Site Public Contact - (BCCclintrials@bmhcc.org) |
| Bay Area Breast Surgeons Inc Emeryville, California | |
| Bay Area Tumor Institute Oakland, California | |
| Bay Pines VA Healthcare System Bay Pines, Florida | Site Public Contact - (vhabayresearch@va.gov) |
| Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston, Texas | Site Public Contact - (burton@bcm.edu) |
| Beacon Kalamazoo Kalamazoo, Michigan | |
| Beacon Kalamazoo Cancer Center Kalamazoo, Michigan | |
| Benefis Sletten Cancer Institute Great Falls, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Bethesda North Hospital Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Billings Clinic Cancer Center Billings, Montana | Site Public Contact - (research@billingsclinic.org) |
| Billings Clinic-Cody Cody, Wyoming | Site Public Contact - (research@billingsclinic.org) |
| Blanchard Valley Hospital Findlay, Ohio | |
| Boston Veteran's Affairs Medical Center Jamaica Plain, Massachusetts | Site Public Contact - (ctsucontact@westat.com) |
| Boulder Community Foothills Hospital Boulder, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Bozeman Health Deaconess Hospital Bozeman, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Bronson Battle Creek Battle Creek, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Bronson Methodist Hospital Kalamazoo, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| CARTI Cancer center Little Rock, Arkansas | Site Public Contact - (Research@CARTI.com) |
| CHI Health Good Samaritan Kearney, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| CHI Health Saint Francis Grand Island, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| CHI Saint Vincent Cancer Center Hot Springs Hot Springs, Arkansas | |
| CTCA at Western Regional Medical Center Goodyear, Arizona | |
| Cambridge Medical Center Cambridge, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Camden Clark Medical Center Parkersburg, West Virginia | Site Public Contact - (cancertrialsinfo@hsc.wvu.edu) |
| Cancer Center at Saint Joseph's Phoenix, Arizona | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Cancer Center of Western Wisconsin New Richmond, Wisconsin | Site Public Contact - (mmcorc@healthpartners.com) |
| Cancer Center-Metro Medical Center Bayamon Bayamón, | |
| Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan | Site Public Contact - (connie.szczepanek@crcwm.org) |
| Carilion Roanoke Memorial Hospital Roanoke, Virginia | |
| Carle Cancer Center Urbana, Illinois | |
| Carle Physician Group-Effingham Effingham, Illinois | |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | |
| Carle at The Riverfront Danville, Illinois | |
| Carson Tahoe Regional Medical Center Carson City, Nevada | Site Public Contact - (research@sncrf.org) |
| Case Western Reserve University Cleveland, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| Central Care Cancer Center - Bolivar Bolivar, Missouri | Site Public Contact - (aroland@kccop.org) |
| Central Care Cancer Center - Garden City Garden City, Kansas | Site Public Contact - (aroland@kccop.org) |
| Central Care Cancer Center - Great Bend Great Bend, Kansas | Site Public Contact - (aroland@kccop.org) |
| Centro Comprensivo de Cancer de UPR San Juan, | Site Public Contact - (Roster@nrgoncology.org) |
| Colorado Blood Cancer Institute Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| CommonSpirit Cancer Center Mercy Durango, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Commonwealth Cancer Center-Corbin Corbin, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Community Hospital of Anaconda Anaconda, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Community Medical Center Missoula, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Community Medical Center Missoula, Montana | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Comprehensive Cancer Centers of Nevada Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada - Henderson Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada - Northwest Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada - Town Center Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Contra Costa Regional Medical Center Martinez, California | |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Lakeland Hospitals - Niles Hospital Niles, Michigan | |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Corewell Health Reed City Hospital Reed City, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Cotton O'Neil Cancer Center / Stormont Vail Health Topeka, Kansas | |
| Cox Cancer Center Branson Branson, Missouri | |
| CoxHealth South Hospital Springfield, Missouri | |
| Creighton University Medical Center Omaha, Nebraska | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Dayton Physician LLC - Englewood Dayton, Ohio | |
| Dayton Physicians LLC - Troy Troy, Ohio | |
| Dayton Physicians LLC-Atrium Franklin, Ohio | |
| Dayton Physicians LLC-Miami Valley South Centerville, Ohio | |
| Dayton Physicians LLC-Wayne Greenville, Ohio | |
| Doctors Cancer Center Manatí, | |
| Duluth Clinic Ashland Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Epic Care Cyberknife Center Walnut Creek, California | |
| Epic Care Partners in Cancer Care Emeryville, California | |
| Epic Care-Dublin Dublin, California | |
| Essentia Health - Baxter Clinic Baxter, Minnesota | |
| Essentia Health - Deer River Clinic Deer River, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Ely Clinic Ely, Minnesota | |
| Essentia Health - Fosston Fosston, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - International Falls Clinic International Falls, Minnesota | |
| Essentia Health - Jamestown Clinic Jamestown, North Dakota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Moose Lake Clinic Moose Lake, Minnesota | |
| Essentia Health - Park Rapids Park Rapids, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health - Saint Joseph's Crosslake Clinic Crosslake, Minnesota | |
| Essentia Health - Saint Joseph's Pequot Lakes Clinic Pequot Lakes, Minnesota | |
| Essentia Health - Saint Joseph's Pine River Clinic Pine River, Minnesota | |
| Essentia Health - Saint Joseph's Staples Clinic Staples, Minnesota | |
| Essentia Health Cancer Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Cancer Center-South University Clinic Fargo, North Dakota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Hibbing Clinic Hibbing, Minnesota | |
| Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Saint Mary's Hospital - Superior Superior, Wisconsin | |
| Essentia Health Saint Mary's Medical Center Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Sandstone Sandstone, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health Virginia Clinic Virginia, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Hayward Clinic Hayward, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Essentia Health-Spooner Clinic Spooner, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Fairbanks Memorial Hospital Fairbanks, Alaska | Site Public Contact - (Veronica.Stevenson@foundationhealth.org) |
| Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Lakes Medical Center Wyoming, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Northland Medical Center Princeton, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Fairview Ridges Hospital Burnsville, Minnesota | |
| Fairview Southdale Hospital Edina, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Flaget Memorial Hospital Bardstown, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Franciscan Research Center-Northwest Medical Plaza Tacoma, Washington | |
| Freeman Health System Joplin, Missouri | Site Public Contact - (LJCrockett@freemanhealth.com) |
| Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center Danville, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania | Site Public Contact - (HemonCCTrials@geisinger.edu) |
| George Washington University Medical Center Washington D.C., District of Columbia | |
| Gibbs Cancer Center-Gaffney Gaffney, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Gibbs Cancer Center-Pelham Greer, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Good Samaritan Hospital - Cincinnati Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Great Falls Clinic Great Falls, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Greater Dayton Cancer Center Kettering, Ohio | |
| Greater Regional Medical Center Creston, Iowa | |
| HIMA San Pablo Oncologic Hospital Caguas, | |
| Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii | Site Public Contact - (i.webster@hawaiicancercare.com) |
| Health Partners Inc Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Heartland Regional Medical Center Saint Joseph, Missouri | Site Public Contact - (Trisha.England2@mymlc.com) |
| Hennepin County Medical Center Minneapolis, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Hi-Line Sletten Cancer Center Havre, Montana | Site Public Contact - (Roster@nrgoncology.org) |
| Highline Medical Center-Main Campus Burien, Washington | |
| Hope Cancer Care of Nevada Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Hope Cancer Care of Nevada-Pahrump Pahrump, Nevada | Site Public Contact - (research@sncrf.org) |
| Idaho Urologic Institute-Meridian Meridian, Idaho | |
| Indu and Raj Soin Medical Center Beavercreek, Ohio | |
| Instituto Oncologia Moderna Ponce Ponce, | |
| Jefferson Healthcare Port Townsend, Washington | |
| Jewish Hospital Louisville, Kentucky | |
| Jewish Hospital Medical Center South Shepherdsville, Kentucky | |
| John H Stroger Jr Hospital of Cook County Chicago, Illinois | |
| Kaiser Permanente - Kensington Medical Center Kensington, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente - Largo Medical Center Largo, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente - Panorama City Panorama City, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente Los Angeles Medical Center Los Angeles, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente Lutherville - Timonium Medical Center Lutherville, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente South Bay Harbor City, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente Tysons Corner Medical Center McLean, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente West Los Angeles Los Angeles, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Anaheim Anaheim, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Baldwin Park Baldwin Park, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Bellflower Bellflower, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Burke Medical Center Burke, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Capitol Hill Medical Center Washington D.C., District of Columbia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Caton Hill Medical Center Woodbridge, Virginia | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Fontana Fontana, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Franklin Denver, Colorado | Site Public Contact - (kristi.m.bronkan@kp.org) |
| Kaiser Permanente-Gaithersburg Medical Center Gaithersburg, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kaiser Permanente-Irvine Irvine, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Lone Tree Lone Tree, Colorado | Site Public Contact - (kristi.m.bronkan@kp.org) |
| Kaiser Permanente-Ontario Ontario, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Riverside Riverside, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Rock Creek Lafayette, Colorado | Site Public Contact - (kristi.m.bronkan@kp.org) |
| Kaiser Permanente-San Diego Mission San Diego, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-San Diego Zion San Diego, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-San Marcos San Marcos, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Vallejo Vallejo, California | Site Public Contact - (Kpoct@kp.org) |
| Kaiser Permanente-Woodland Hills Woodland Hills, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Woodlawn Medical Center Baltimore, Maryland | Site Public Contact - (Charmaine.A.Mckie@kp.org) |
| Kansas City Veterans Affairs Medical Center Kansas City, Missouri | |
| Kapiolani Medical Center for Women and Children Honolulu, Hawaii | |
| Kettering Medical Center Kettering, Ohio | |
| Kingman Regional Medical Center Kingman, Arizona | Site Public Contact - (research@sncrf.org) |
| Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho | Site Public Contact - (mccinfo@mtcancer.org) |
| Kuakini Medical Center Honolulu, Hawaii | |
| Lake Region Healthcare Corporation-Cancer Care Fergus Falls, Minnesota | |
| Lake Regional Hospital Osage Beach, Missouri | Site Public Contact - (clinicaltrials@lakeregional.com) |
| Lakeview Hospital Stillwater, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Las Vegas Urology - Cathedral Rock Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Las Vegas Urology - Green Valley Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Las Vegas Urology - Pebble Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Las Vegas Urology - Pecos Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Las Vegas Urology - Smoke Ranch Las Vegas, Nevada | Site Public Contact - (research@smcrf.org) |
| Las Vegas Urology - Sunset Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York | Site Public Contact - (CancerTrials@nyulangone.org) |
| Logan Health Medical Center Kalispell, Montana | Site Public Contact - (mccinfo@mtcancer.org) |
| Longmont United Hospital Longmont, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Louis Stokes Cleveland VA Medical Center Cleveland, Ohio | Site Public Contact - (holly.henry@va.gov) |
| Lovelace Medical Center-Saint Joseph Square Albuquerque, New Mexico | Site Public Contact - (ZPollock@salud.unm.edu) |
| Low Country Cancer Care Savannah, Georgia | Site Public Contact - (Lorraine.OHara@hcahealthcare.com) |
| Loyola University Medical Center Maywood, Illinois | |
| MaineHealth Maine Medical Center- Scarborough Scarborough, Maine | Site Public Contact - (clinicalresearch@mainehealth.org) |
| Malcom Randall Veterans Administration Medical Center Gainesville, Florida | Site Public Contact - (trials@cancer.ufl.edu) |
| Marshfield Clinic-Wausau Center Wausau, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center - Minocqua Minocqua, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center - Weston Weston, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-Marshfield Marshfield, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin | Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org) |
| Massachusetts General Hospital Cancer Center Boston, Massachusetts | |
| Mayo Clinic in Rochester Rochester, Minnesota | |
| MedStar Georgetown University Hospital Washington D.C., District of Columbia | |
| Memorial Health University Medical Center Savannah, Georgia | Site Public Contact - (Lorraine.OHara@hcahealthcare.com) |
| Mercy Cancer Center Merced, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Cape Girardeau Cape Girardeau, Missouri | |
| Mercy Cancer Center - Carmichael Carmichael, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Elk Grove Elk Grove, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Rocklin Rocklin, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center - Sacramento Sacramento, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Cancer Center-West Lakes Clive, Iowa | |
| Mercy Clinic-Rolla-Cancer and Hematology Rolla, Missouri | |
| Mercy Health - Paducah Cancer Center Paducah, Kentucky | Site Public Contact - (BJWarner@mercy.com) |
| Mercy Hospital Coon Rapids, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mercy Hospital Fort Smith Fort Smith, Arkansas | |
| Mercy Hospital Joplin Joplin, Missouri | Site Public Contact - (esmeralda.carrillo@mercy.net) |
| Mercy Hospital Oklahoma City Oklahoma City, Oklahoma | |
| Mercy Hospital Pittsburg Pittsburg, Kansas | |
| Mercy Hospital Saint Louis St Louis, Missouri | |
| Mercy Hospital South St Louis, Missouri | Site Public Contact - (Danielle.Werle@mercy.net) |
| Mercy Hospital Springfield Springfield, Missouri | |
| Mercy Hospital Washington Washington, Missouri | |
| Mercy Infusion Center - Chippewa St Louis, Missouri | |
| Mercy Medical Center Springfield, Massachusetts | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mercy Medical Center - Des Moines Des Moines, Iowa | |
| Mercy Medical Center-West Lakes West Des Moines, Iowa | |
| Mercy Oncology and Hematology - Clayton-Clarkson Ballwin, Missouri | |
| Mercy San Juan Medical Center Carmichael, California | Site Public Contact - (OncologyResearch@DignityHealth.org) |
| Miami Valley Cancer Care and Infusion Greenville, Ohio | |
| Miami Valley Hospital Dayton, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Miami Valley Hospital North Dayton, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Miami Valley Hospital South Centerville, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Midlands Community Hospital Papillion, Nebraska | |
| Midwestern Regional Medical Center Zion, Illinois | |
| Miller-Dwan Hospital Duluth, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Minneapolis VA Medical Center Minneapolis, Minnesota | |
| Minnesota Oncology - Burnsville Burnsville, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Mission Hope Medical Oncology - Santa Maria Santa Maria, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Monticello Cancer Center Monticello, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Morristown Medical Center Morristown, New Jersey | |
| Mount Sinai Comprehensive Cancer Center at Aventura Aventura, Florida | Site Public Contact - (yenrique@msmc.com) |
| Mount Sinai Medical Center Miami Beach, Florida | Site Public Contact - (yenrique@msmc.com) |
| Mountain Blue Cancer Care Center - Swedish Englewood, Colorado | |
| Munson Medical Center Traverse City, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York, New York | Site Public Contact - (cancerclinicaltrials@cumc.columbia.edu) |
| Nebraska Cancer Specialists/Oncology Hematology West PC Grand Island, Nebraska | |
| New Ulm Medical Center New Ulm, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| North Grove Medical Park Spartanburg, South Carolina | |
| North Memorial Medical Health Center Robbinsdale, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima, Washington | Site Public Contact - (Memorial-ClinicalTrials@yvmh.org) |
| Northwest Cancer Center - Hobart Hobart, Indiana | |
| Northwest Cancer Center - Main Campus Crown Point, Indiana | |
| Northwest Cancer Center - Valparaiso Valparaiso, Indiana | Site Public Contact - (CancerResearch@COMHS.org) |
| Northwest Oncology LLC Dyer, Indiana | |
| Northwest Wisconsin Cancer Center Ashland, Wisconsin | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Northwestern University Chicago, Illinois | Site Public Contact - (cancer@northwestern.edu) |
| OSF Saint Anthony's Health Center Alton, Illinois | |
| Ohio State University Comprehensive Cancer Center Columbus, Ohio | Site Public Contact - (Jamesline@osumc.edu) |
| Oncology Hematology Care Inc-Kenwood Cincinnati, Ohio | |
| Oncology Las Vegas - Henderson Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Oncology Las Vegas - Tenaya Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| OptumCare Cancer Care at Charleston Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| OptumCare Cancer Care at Fort Apache Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| OptumCare Cancer Care at MountainView Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| OptumCare Cancer Care at Seven Hills Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Oregon Health and Science University Portland, Oregon | Site Public Contact - (trials@ohsu.edu) |
| Orion Cancer Care Findlay, Ohio | |
| PCR Oncology Arroyo Grande, California | Site Public Contact - (research@sncrf.org) |
| PROncology San Juan, | Site Public Contact - (info@PRoncology.com) |
| Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Pali Momi Medical Center ‘Aiea, Hawaii | |
| Pan American Center for Oncology Trials LLC San Juan, | Site Public Contact - (marcia.cruzcorrea@panoncologytrials.com) |
| Pan American Center for Oncology Trials LLC - Ciudadela San Juan, | Site Public Contact - (info@panoncologytrials.com) |
| Pan American Center for Oncology Trials LLC - Dorado Dorado, | Site Public Contact - (info@panoncologytrials.com) |
| Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Penrose-Saint Francis Healthcare Colorado Springs, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Phelps Health Delbert Day Cancer Institute Rolla, Missouri | Site Public Contact - (research@phelpshealth.org) |
| Piedmont Hospital Atlanta, Georgia | Site Public Contact - (ORS@piedmont.org) |
| Premier Blood and Cancer Center Dayton, Ohio | |
| Presbyterian - Saint Lukes Medical Center - Health One Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Primary Care Physician Group San Juan, | |
| Princeton Community Hospital Princeton, West Virginia | |
| Prisma Health Greenville Memorial Hospital Greenville, South Carolina | Site Public Contact - (Kim.Williams3@prismahealth.org) |
| Providence Veterans Administration Hospital Providence, Rhode Island | |
| Puerto Rico Hematology Oncology Group Bayamón, | |
| Queen's Cancer Center - Kuakini Honolulu, Hawaii | |
| Queen's Cancer Center - Pearlridge ‘Aiea, Hawaii | |
| Queen's Medical Center Honolulu, Hawaii | |
| Radiation Oncology Associates Reno, Nevada | Site Public Contact - (research@sncrf.org) |
| Radiation Oncology Centers of Nevada Central Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Radiation Oncology Centers of Nevada Southeast Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Ralph H Johnson VA Medical Center Charleston, South Carolina | Site Public Contact - (ashley.salvo@va.gov) |
| Regions Hospital Saint Paul, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Reid Health Richmond, Indiana | |
| Renown Regional Medical Center Reno, Nevada | Site Public Contact - (research@sncrf.org) |
| Rice Memorial Hospital Willmar, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Ridgeview Medical Center Waconia, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Riverwood Healthcare Center Aitkin, Minnesota | Site Public Contact - (CancerTrials@EssentiaHealth.org) |
| Robert J Dole VA Medical Center Wichita, Kansas | |
| Rocky Mountain Cancer Centers - Centennial Centennial, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers - Swedish Englewood, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Aurora Aurora, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Boulder Boulder, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Lakewood Lakewood, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Littleton Littleton, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Longmont Longmont, Colorado | Site Public Contact - (ResearchTracking@Centura.Org) |
| Rocky Mountain Cancer Centers-Midtown Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Penrose Colorado Springs, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Rocky Mountain Cancer Centers-Rose Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Cancer Centers-Thornton Thornton, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| Rocky Mountain Regional VA Medical Center Aurora, Colorado | |
| Rush MD Anderson Cancer Center Chicago, Illinois | |
| Rush-Copley Healthcare Center Yorkville, Illinois | |
| Rush-Copley Medical Center Aurora, Illinois | |
| SMC Center for Hematology Oncology Union Union, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| SSM Health Good Samaritan Mount Vernon, Illinois | Site Public Contact - (gayla.hall@ssmhealth.com) |
| Saint Alphonsus Cancer Care Center-Baker City Baker City, Oregon | |
| Saint Alphonsus Cancer Care Center-Boise Boise, Idaho | |
| Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho | |
| Saint Alphonsus Cancer Care Center-Nampa Nampa, Idaho | |
| Saint Alphonsus Cancer Care Center-Ontario Ontario, Oregon | |
| Saint Anthony Hospital Lakewood, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Anthony North Hospital Westminster, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Catherine Hospital Garden City, Kansas | Site Public Contact - (Roster@nrgoncology.org) |
| Saint Clare Hospital Lakewood, Washington | |
| Saint Elizabeth Boardman Hospital Boardman, Ohio | |
| Saint Elizabeth Healthcare Edgewood Edgewood, Kentucky | Site Public Contact - (Kristi.Curtsinger@stelizabeth.com) |
| Saint Elizabeth Healthcare Fort Thomas Fort Thomas, Kentucky | Site Public Contact - (Kristi.Curtsinger@stelizabeth.com) |
| Saint Elizabeth Hospital Enumclaw, Washington | |
| Saint Elizabeth Regional Medical Center Lincoln, Nebraska | |
| Saint Elizabeth Youngstown Hospital Youngstown, Ohio | |
| Saint Francis Cancer Center Greenville, South Carolina | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Francis Hospital Federal Way, Washington | |
| Saint Francis Regional Medical Center Shakopee, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Saint John's Hospital - Healtheast Maplewood, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Saint Joseph Hospital Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Hospital East Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph London London, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Mount Sterling Mount Sterling, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Radiation Oncology Resource Center Lexington, Kentucky | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Joseph Regional Cancer Center Bryan, Texas | |
| Saint Joseph Warren Hospital Warren, Ohio | |
| Saint Joseph's Medical Center Stockton, California | |
| Saint Luke's Cancer Center - Allentown Allentown, Pennsylvania | |
| Saint Luke's Hospital - Monroe Campus Stroudsburg, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| Saint Luke's Hospital - Upper Bucks Campus Quakertown, Pennsylvania | |
| Saint Luke's Hospital-Anderson Campus Easton, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| Saint Luke's University Hospital-Bethlehem Campus Bethlehem, Pennsylvania | |
| Saint Mary Corwin Medical Center Pueblo, Colorado | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Mary Medical Center Hobart, Indiana | Site Public Contact - (CancerResearch@COMHS.org) |
| Saint Mary's Hospital Centralia, Illinois | Site Public Contact - (Roster@nrgoncology.org) |
| Saint Mary's Regional Medical Center Reno, Nevada | Site Public Contact - (research@sncrf.org) |
| Saint Michael Cancer Center Silverdale, Washington | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin | Site Public Contact - (WI_research_admin@hshs.org) |
| Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin | Site Public Contact - (wi_research_admin@hshs.org) |
| Saints Mary and Elizabeth Hospital Louisville, Kentucky | |
| San Juan City Hospital San Juan, | |
| San Juan Community Oncology Group San Juan, | |
| San Juan Veterans Affairs Medical Center San Juan, | Site Public Contact - (sajresearchcontactus@va.gov) |
| Sanford Bismarck Medical Center Bismarck, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford Broadway Medical Center Fargo, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota | Site Public Contact - (OncologyClinicTrialsSF@sanfordhealth.org) |
| Sanford Cancer Center Worthington Worthington, Minnesota | |
| Sanford Joe Lueken Cancer Center Bemidji, Minnesota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford Medical Center Fargo Fargo, North Dakota | |
| Sanford Roger Maris Cancer Center Fargo, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford South University Medical Center Fargo, North Dakota | |
| Sanford Thief River Falls Medical Center Thief River Falls, Minnesota | |
| Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota | Site Public Contact - (OncologyClinicalTrialsSF@SanfordHealth.org) |
| Southeastern Medical Oncology Center-Clinton Clinton, North Carolina | Site Public Contact - (jfields@cancersmoc.com) |
| Southeastern Medical Oncology Center-Goldsboro Goldsboro, North Carolina | Site Public Contact - (jfields@cancersmoc.com) |
| Southeastern Medical Oncology Center-Jacksonville Jacksonville, North Carolina | Site Public Contact - (jfields@cancersmoc.com) |
| Southpointe-Sanford Medical Center Fargo Fargo, North Dakota | |
| Sovah Health Martinsville Martinsville, Virginia | |
| Spartanburg Medical Center Spartanburg, South Carolina | Site Public Contact - (kmertz-rivera@gibbscc.org) |
| Spartanburg Medical Center - Mary Black Campus Spartanburg, South Carolina | |
| Stanford Cancer Institute Palo Alto Palo Alto, California | Site Public Contact - (ccto-office@stanford.edu) |
| Straub Clinic and Hospital Honolulu, Hawaii | |
| Summerlin Hospital Medical Center Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Sunrise Hospital and Medical Center Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Tamarack Health Hayward Medical Center Hayward, Wisconsin | |
| The Carle Foundation Hospital Urbana, Illinois | |
| The Community Hospital Munster, Indiana | |
| The Melanoma and Skin Cancer Institute Englewood, Colorado | Site Public Contact - (ryan.weight@theskincancerinstitute.com) |
| The Women's Imaging Center Denver, Colorado | Site Public Contact - (info@westernstatesncorp.org) |
| TriHealth Cancer Institute-Anderson Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| TriHealth Cancer Institute-Westside Cincinnati, Ohio | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Trinity Health Grand Rapids Hospital Grand Rapids, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| Trinity Health Muskegon Hospital Muskegon, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| UCHealth University of Colorado Hospital Aurora, Colorado | |
| UCLA / Jonsson Comprehensive Cancer Center Los Angeles, California | |
| UHHS-Chagrin Highlands Medical Center Beachwood, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| UHHS-Westlake Medical Center Westlake, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines, Iowa | |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa | |
| UPMC-Presbyterian Hospital Pittsburgh, Pennsylvania | |
| UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas | |
| United Hospital Saint Paul, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| United Hospital Center Bridgeport, West Virginia | |
| Unity Hospital Fridley, Minnesota | |
| University Medical Center of Southern Nevada Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| University of Arizona Cancer Center - Prevention Research Clinic Tucson, Arizona | Site Public Contact - (schow@azcc.arizona.edu) |
| University of Cincinnati Cancer Center-UC Medical Center Cincinnati, Ohio | |
| University of Cincinnati Cancer Center-West Chester West Chester, Ohio | |
| University of Hawaii Cancer Center Honolulu, Hawaii | |
| University of Kansas Cancer Center Kansas City, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Clinical Research Center Fairway, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Hospital-Indian Creek Campus Overland Park, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida | |
| University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan | |
| University of Michigan Health - West Wyoming, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| University of New Mexico Cancer Center Albuquerque, New Mexico | Site Public Contact - (HSC-ClinicalTrialInfo@salud.unm.edu) |
| UofL Health Medical Center Northeast Louisville, Kentucky | |
| Upper Valley Medical Center Troy, Ohio | Site Public Contact - (clinical.trials@daytonncorp.org) |
| Urology Specialists of Nevada - Central Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Urology Specialists of Nevada - Green Valley Henderson, Nevada | Site Public Contact - (research@sncrf.org) |
| Urology Specialists of Nevada - Northwest Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| Urology Specialists of Nevada - Southwest Las Vegas, Nevada | Site Public Contact - (research@sncrf.org) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| Valley Medical Center Renton, Washington | Site Public Contact - (research@valleymed.org) |
| Veterans Administration Medical Center - Oklahoma City Oklahoma City, Oklahoma | Site Public Contact - (Roster@nrgoncology.org) |
| Veterans Affairs Connecticut Healthcare System-West Haven Campus West Haven, Connecticut | |
| WVUH-Berkely Medical Center Martinsburg, West Virginia | |
| Walter Knox Memorial Hospital Emmett, Idaho | |
| Wayne Hospital Greenville, Ohio | |
| Welch Cancer Center Sheridan, Wyoming | |
| West Michigan Cancer Center Kalamazoo, Michigan | Site Public Contact - (crcwm-regulatory@crcwm.org) |
| West Virginia University Healthcare Morgantown, West Virginia | Site Public Contact - (cancertrialsinfo@hsc.wvu.edu) |
| Wheeling Hospital/Schiffler Cancer Center Wheeling, West Virginia | |
| Wilcox Memorial Hospital and Kauai Medical Clinic Lihue, Hawaii | |
| William S Middleton VA Medical Center Madison, Wisconsin | |
| Women's Cancer Center of Nevada Las Vegas, Nevada | |
| Women's Diagnostic Center - Munster Munster, Indiana | Site Public Contact - (mnicholson@comhs.org) |
| Woodland Memorial Hospital Woodland, California | Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org) |
| Yale University New Haven, Connecticut | Site Public Contact - (canceranswers@yale.edu) |
| Yale-New Haven Hospital North Haven Medical Center North Haven, Connecticut | Site Public Contact - (canceranswers@yale.edu) |
| Yale-New Haven Hospital Saint Raphael Campus New Haven, Connecticut | Site Public Contact - (canceranswers@yale.edu) |
| Zablocki Veterans Administration Medical Center Milwaukee, Wisconsin |
Safety and Effectiveness of Cochlear Implantation in an Expanded Adult Population (ACE)
Lavin Entwisle - lentwisle@cochlear.com
NCT06293482
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Individuals 18 or older at the time of consent
* Meets the following audiometric criteria for the ear to be implanted: clinically established sensorineural hearing loss (SNHL) defined by a four frequency pure tone average (PTA) at 500, 1000, 2000, \& 4000 Hz of: ≥60 dB HL and compromised functional hearing in the aided condition defined as \<50% correct on a word recognition test
* Meets the following audiometric criteria for the non-implanted contralateral ear: clinically established SNHL defined by a four frequency PTA at 500, 1000, 2000, \& 4000 Hz of \>30 dB HL
* Candidate is a fluent speaker in the language used to assess speech perception performance as determined by the investigator.
* Willing and able to provide written informed consent.
Exclusion Criteria:
* Meets current indications on audiometric thresholds for traditional adult CI candidates (i.e., bilateral moderate to profound hearing loss in the low frequencies and profound \[≥ 90 dB HL\] hearing loss in the mid to high speech frequencies)
* Absence of cochlea development or a cochlear nerve
* Presence of active middle ear infection in the ear to be implanted
* Tympanic membrane perforation in the presence of active middle ear disease in the ear to be implanted
* Medical or psychological conditions that contraindicate general anaesthesia, surgery, or participation in the clinical investigation.
* Existing contralateral cochlear implant or medical plan to implant a contralateral cochlear implant during the clinical investigation.
* Pregnant or breastfeeding women. Women who plan to become pregnant during the course of the clinical investigation.
* Unrealistic expectations on the part of the participant, regarding the possible benefits, risks, and limitations that are inherent to the surgical procedure(s) and prosthetic devices as determined by the investigator.
* Additional disabilities that may affect the participant's participation of safety during the clinical investigation.
* Unable or unwilling to comply with all of the requirements of the clinical investigation as determined by the investigator.
* Investigator site personnel directly affiliated with this study and/or their immediate families; immediate family is defined as a spouse, parent, child, or sibling.
* Employees of Cochlear.
* Current participation, or participation in another interventional clinical study/trial in the past 30 days, involving an investigational drug or device (unless the other investigation was/is a Cochlear sponsored investigation and determined by the investigator or Sponsor to not impact this investigation. DEVICE: Cochlear™ Nucleus® System
Hearing Loss, Sensorineural, Hearing Loss, Bilateral
Cochlear implant, Sensorineural hearing loss, Safety, Efficacy
I'm interested
Share via email
Show 11 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Barrow Neurological Institute Phoenix, Arizona | Shawn Stevens - (shawn.stevens@commonspirit.org) |
| Centre for Neurosciences Tucson, Arizona | Gwendolyn Grabiec - (GGrabiec@neurotucson.com) |
| Cleveland Clinic Cleveland, Ohio | Sarah Sydlowski - (sydlows@ccf.org) |
| Indiana University Indianapolis, Indiana | Rick Nelson, MD - (ricnelso@iupui.edu) |
| Midwest Ear Institute Kansas City, Missouri | Sarah Zlomke - (sking@saint-lukes.org) |
| New York University New York, New York | William Shapiro - (william.shapiro@nyulangone.org) |
| Pacific Neuroscience Institute Santa Monica, California | Courtney Voelker, MD - (Courtney.Voelker@providence.org) |
| University of Miami Miami, Florida | Meredith Holcomb - (meredith.holcomb@med.miami.edu) |
| University of Pennsylvania Hospitals Philadelphia, Pennsylvania | Tiffany Hwa - (tiffany.hwa@pennmedicine.upenn.edu) |
| Virginia Commonwealth University Richmond, Virginia | |
| Virginia Mason Seattle, Washington |
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
Clinical Trials Administrator - clinicaltrials@regeneron.com
NCT03564340
Show full eligibility criteria
Hide eligibility criteria
Key
• Ovarian Cancer Cohorts Only: Patients with histologically or cytologically confirmed diagnosis of advanced, epithelial ovarian cancer (except carcinosarcoma), primary peritoneal, or fallopian tube cancer who have all of the following:
• serum CA-125 level ≥2 x upper limit of normal (ULN) (in screening, not required for low-grade serous carcinoma)
• has received at least 1 line of platinum-containing therapy or must be platinum-intolerant (applicable for dose escalation and non-randomized dose expansion cohorts)
• documented relapse or progression on or after the most recent line of therapy
• no standard therapy options likely to convey clinical benefit
• Adequate organ and bone marrow function as defined in the protocol
• Life expectancy of at least 3 months
• Randomized phase 2 expansion cohort (Ovarian Cancer only): Platinum-resistant ovarian cancer patients who have had 2 to 4 lines of platinum-based therapy as defined in the protocol.
• Endometrial Cancer Cohorts Only: histologically confirmed endometrial cancer that has progressed or recurrent after prior anti-Programmed Cell Death Ligand 1 (PD-1) therapy and platinum-based chemotherapy:
• MUC16 positivity of tumor cells ≥25% by immunohistochemistry (IHC), as defined in the protocol
• 1-4 prior lines of systemic therapy, as described in the protocol Key
• Prior treatment with anti-Programmed Cell Death (PD-1)/PD-L1 therapy, as described in the protocol
• Ovarian Cancer Expansion cohorts only: More than 4 prior lines of cytotoxic chemotherapy (does not apply to low-grade serous ovarian cancer cohort)
• Prior treatment with a MUC16 - targeted therapy
• Untreated or active primary brain tumor, central nervous system (CNS) metastases, or spinal cord compression, as described in the protocol
• History and/or current cardiovascular disease, as defined in the protocol
• Severe and/or uncontrolled hypertension at screening. Patients taking anti-hypertensive medication must be on a stable anti-hypertensive regimen Note: Other protocol-defined Inclusion/Exclusion Criteria apply
Inclusion Criteria:
• Ovarian Cancer Cohorts Only: Patients with histologically or cytologically confirmed diagnosis of advanced, epithelial ovarian cancer (except carcinosarcoma), primary peritoneal, or fallopian tube cancer who have all of the following:
• serum CA-125 level ≥2 x upper limit of normal (ULN) (in screening, not required for low-grade serous carcinoma)
• has received at least 1 line of platinum-containing therapy or must be platinum-intolerant (applicable for dose escalation and non-randomized dose expansion cohorts)
• documented relapse or progression on or after the most recent line of therapy
• no standard therapy options likely to convey clinical benefit
• Adequate organ and bone marrow function as defined in the protocol
• Life expectancy of at least 3 months
• Randomized phase 2 expansion cohort (Ovarian Cancer only): Platinum-resistant ovarian cancer patients who have had 2 to 4 lines of platinum-based therapy as defined in the protocol.
• Endometrial Cancer Cohorts Only: histologically confirmed endometrial cancer that has progressed or recurrent after prior anti-Programmed Cell Death Ligand 1 (PD-1) therapy and platinum-based chemotherapy:
• MUC16 positivity of tumor cells ≥25% by immunohistochemistry (IHC), as defined in the protocol
• 1-4 prior lines of systemic therapy, as described in the protocol Key
Exclusion Criteria:
• Prior treatment with anti-Programmed Cell Death (PD-1)/PD-L1 therapy, as described in the protocol
• Ovarian Cancer Expansion cohorts only: More than 4 prior lines of cytotoxic chemotherapy (does not apply to low-grade serous ovarian cancer cohort)
• Prior treatment with a MUC16 - targeted therapy
• Untreated or active primary brain tumor, central nervous system (CNS) metastases, or spinal cord compression, as described in the protocol
• History and/or current cardiovascular disease, as defined in the protocol
• Severe and/or uncontrolled hypertension at screening. Patients taking anti-hypertensive medication must be on a stable anti-hypertensive regimen Note: Other protocol-defined Inclusion/Exclusion Criteria apply
DRUG: Ubamatamab, DRUG: Cemiplimab, DRUG: Sarilumab, DRUG: Tocilizumab
Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Primary Peritoneal Cancer, Recurrent Endometrial Cancer, Endometrial Cancer, Low-grade Serous Ovarian Cancer
I'm interested
Share via email
Show 52 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Asan Medical Center, Univ. of Ulsan Seoul, | |
| Centre Antoine Lacassagne Nice, | |
| Centre Francois Baclesse (CFB) Caen, Normandy | |
| Centre Georges Francois Leclerc Dijon, | |
| Clinica Universidad Navarra (CUN) Madrid Madrid, | |
| Clinica Universidad de Navarra Madrid, | |
| Columbia University Medical Center New York, New York | |
| Dana Farber / Harvard Cancer Center Boston, Massachusetts | |
| Erasmus MC Rotterdam, | |
| Fondazione Policlinico Universitario Agostino Gemelli Irccs Roma, | |
| Fundacion Jimenez Diaz Madrid, | |
| Grand Hopital de Charleroi Charleroi, Hainaut | |
| Guys Hospital London, | |
| Hopital Lyon Sud Lyon, Pierre-Benite | |
| Hospital Clinico Universitatio Santiago de Compostela Santiago de Compostela, | |
| Hospital Universitari Vall d'Hebron Barcelona, | |
| Hospital Universitario San Carlos Madrid, | |
| Imperial College Healthcare NHS Trust London, Greater London | |
| Institut Bergonie Bordeaux, | |
| Institut Catala d'Oncologia Barcelona, | |
| Institut Catala d'Oncologia Barcelona, | |
| Institut Catala dOncologia Badalona Badalona, | |
| Institut Gustave Roussy Villejuif, | |
| Instituto Nazionale Tumori- Fondazione Pascale Naples, | |
| Istituto Europeo Di Oncologia Milan, | |
| Korea University Guro Hospital Seoul, | |
| Massachusetts General Hospital Boston, Massachusetts | |
| Mayo Clinic - Rochester Rochester, Minnesota | |
| Memorial Sloan Kettering Cancer Center New York, New York | |
| Peter MacCallum Cancer Center Melbourne, Victoria | |
| Prince of Wales Hospital Grimsby, | |
| Radboudumc Nijmegen, Gelderland | |
| Rambam Health Care Campus Haifa, | |
| Roswell Park Cancer Institute Buffalo, New York | |
| Royal Marsden Hospital - Sutton Sutton, Surrey | |
| Samsung Medical Center Seoul, | |
| Sarah Cannon Research Institute London, England | |
| Seoul National University Hospital Seoul, | |
| Sharet Institute of Oncology Jerusalem, | |
| Sheba Medical Center Ramat Gan, | |
| Stephenson Cancer Center Oklahoma City, Oklahoma | |
| The Christie NHS Foundation Trust Manchester, | |
| The Ohio State University Wexner Medical Center James Comprehensive Cancer Center Hilliard, Ohio | |
| The Royal Marsden NHS Foundation Trust London, | |
| UZLeuven Leuven, Vlaams Brabant | |
| Universitair Ziekenhuis Antwerpen Edegem, | |
| University College London Hospitals London, | |
| University Medical Center Groningen Groningen, | |
| University of Alabama_6th Ave Birmingham, Alabama | |
| University of Oxford Oxford, Oxfordshire | |
| Virginia Commonwealth University Richmond, Virginia | |
| Yonsei University Health System Seoul, |
FXR Effect on Severe Alcohol-Associated Hepatitis (FRESH) Study (FRESH)
Steven Lauder - steven.lauder@interceptpharma.com
NCT05639543
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
• Males or females aged 18 to 65 years (inclusive)
• Clinical diagnosis of sAH based on all the following:
• History of ongoing excess alcohol (\>60 g/day \[male\] or \>40 g/day \[female\]) use for ≥6 months, with \<60 days of abstinence prior to the onset of jaundice
• Serum total bilirubin \>3.0 mg/dL
• Aspartate aminotransferase (AST) ≥50 U/L
• AST/Aspartate aminotransferase (ALT) ratio ≥1.5
• Onset of jaundice within prior 8 weeks
• Cohort 1 through Cohort 4: Maddrey's Discriminant Factor (mDF) ≥32 and ≤70
• Cohort 5 and Cohort 6: mDF ≥32
• Cohort 1 through Cohort 4: MELD score ≥18 to ≤25 (inclusive) and Cohort 5 and Cohort 6: MELD score ≥21 to ≤30
• Female participants must be postmenopausal, surgically sterile, or, if premenopausal (and not surgically sterile), be prepared to use ≥1 highly effective method of contraception from the initiation of Screening and for 90 days after the last dose of investigational product as follows: * Surgical sterilization (bilateral tubal occlusion, etc.) * Placement of an intrauterine device (IUD) or intrauterine system (e.g., intrauterine hormone-releasing system \[IUS\]) * Combined (estrogen and progesterone containing) hormonal contraceptive associated with inhibition of ovulation: * Oral * Intravaginal * Transdermal * Progesterone-only hormonal contraception associated with inhibition of ovulation: * Oral * Injectable * Implantable * Sexual abstinence: When in line with the preferred and usual lifestyle of the participant, is defined as avoiding all types of activity that could result in conception (pregnancy) from the initiation of Screening and until at least 90 days after the last dose of investigational product
• Male participants who are sexually active with female partners of childbearing potential must agree to use a condom with spermicide and to use 1 other approved method of highly effective contraception from the initiation of Screening and until at least 90 days after the dose of investigational product as listed in Inclusion Criteria #3.
• Male participants must refrain from sperm donation from the initiation of Screening and until at least 90 days after the last dose of investigational product
• Must provide written informed consent and agree to comply with the study protocol. In participants with hepatic encephalopathy which may impair decision-making, consent will be obtained per hospital procedures (e.g., by Legally Authorized Representative).
• Participants must agree to participate in an alcohol use disorder program during the study period, as recommended by the local institution's addiction medicine specialists, including post-hospitalization
Exclusion Criteria:
• Participants taking products containing obeticholic acid in the 30 days prior to randomization
• Participants taking \>2 doses of systemic corticosteroids within 30 days prior to randomization.
• Participants who have been inpatient at a referral hospital for \>7 days prior to transfer.
• Pregnancy, planned pregnancy, potential for pregnancy (e.g., unwillingness to use effective birth control during the study), or current or planned breast feeding.
• Abstinence from alcohol consumption for \>2 months before Day 1.
• AST or ALT \>400 U/L.
• Cohort 1 through Cohort 4: mDF \<32 or \>70.
• Cohort 5 and Cohort 6: mDF \<32
• Cohort 1 through Cohort 4: MELD score \<18 or \>25.
• Cohort 5 and Cohort 6: MELD \<21 or \>30
• Other causes of liver disease including chronic hepatitis B (hepatitis B surface antigen \[HBsAg\] positive), chronic hepatitis C virus (HCV) RNA positive, drug-induced liver injury (DILI), biliary obstruction, and autoimmune liver disease.
• Current or previous history of hepatocellular carcinoma (HCC)
• History of liver transplantation or currently listed for liver transplant
• Untreated infection (e.g., has not initiated appropriate medical treatment for infection)
• Known positivity for human immunodeficiency virus infection
• Uncontrolled gastrointestinal (GI) bleeding or controlled GI bleeding that was associated with shock or required transfusion of more than 3 units of blood within 7 days of Screening.
• Kidney injury defined as a serum creatinine \>133 μmol/L (\>1.5 mg/dL) or the requirement for renal replacement therapy whether prior to or after study screening.
• Portal vein thrombosis
• Acute pancreatitis or acute gallbladder disease (e.g., cholecystitis)
• Severe, on-going associated disease (e.g., cardiac failure, acute myocardial infarction, severe cardiac arrhythmias, severe pulmonary disease, neurologic disease)
• Malignancy within the 2 years prior to Screening, with the exception of specific cancers that have been cured by surgical resection (e.g., basal cell skin cancer). Participants under evaluation for possible malignancy are not eligible.
• Positive urine drug screen (amphetamines, barbiturates, benzodiazepines, cocaine, and opiates) except tetrahydrocannabinol or in the setting of documented prescription medications (e.g., opiates, benzodiazepines, amphetamines, barbiturates), which also include medications prescribed as part of in-patient management. Participants being treated for alcohol withdrawal may be exempt for this reason, verify with Medical Monitor.
• Participated in a clinical research study and received any active investigational product being evaluated for the treatment of sAH within 3 months before Day 1
• Participation in a study of another investigational medicine or device within 30 days before Screening
• Any other condition or clinical laboratory result that, in the opinion of the Investigator, might confound the results, or would impede compliance or hinder completion of the study
• Participants treated in the Dose Escalation Phase (Cohort 1 through Cohort 4) are not eligible for enrollment into an Extension Cohort (Cohort 5 and Cohort 6), and participants treated in Cohort 5 are not eligible for enrollment into Cohort 6.
DRUG: INT-787, DRUG: Placebo
Alcohol Associated Hepatitis
Severe Alcohol associated Hepatitis (sAH), Alcoholic Hepatitis (AH), Hepatitis, Alcoholic
I'm interested
Share via email
Show 31 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Baylor College of Medicine Houston, Texas | Megha Bhongade - (megha.bhongade@bcm.edu) |
| Beth Israel Deaconess Medical Center Boston, Massachusetts | |
| CHU Angers Angers, | |
| Cambridge University NHS Foundation Trust Cambridge, | |
| Clinical Translational Research Site Miami, Florida | |
| Columbia University Medical Center/New York Presbyterian Hospital New York, New York | |
| Henry Ford Health System Detroit, Michigan | |
| Hopital Beaujon Clichy, | |
| Hopital Claude Huriez Lille, | |
| Hopital Rangueil Toulouse, | |
| Hospital of the University of Pennsylvania Philadelphia, Pennsylvania | |
| Hôpital Pitié Salpêtrière Paris, | |
| Imperial College Healthcare NHS Trust London, Greater London | |
| King's College Hospital London, | Andrew Ayers - (Andrew.ayers@nhs.net) |
| Mayo Clinic Jacksonville, Florida | |
| Medical University of South Carolina Charleston, South Carolina | |
| Mercy Medical Center Springfield, Massachusetts | |
| Northwell Health Center for Liver Disease and Transplantation Manhasset, New York | |
| Parkland Health and Hospital System Dallas, Texas | |
| Royal Free Hospital London, | |
| Rush University Medical Center Chicago, Illinois | |
| Rutgers-New Jersey Medical School Newark, New Jersey | |
| Stanford Healthcare Stanford, California | |
| Tampa General Medical Group Tampa, Florida | |
| The Liver Institute at Methodist Dallas Medical Center Dallas, Texas | |
| UMass Memorial Medical Center Worcester, Massachusetts | Anne Foley - (anne.foley@umassmemorial.org) |
| University Hospitals Plymouth NHS Trust Plymouth, | |
| University of Texas Southwestern Medical Center Dallas, Texas | |
| University of Utah Hospital Salt Lake City, Utah | |
| VCU Health Clinical Research Services Unit Richmond, Virginia | |
| Vanderbilt Digestive Disease Center Nashville, Tennessee |
Psychobiological Responses Following Exercise and Brain Stimulation
Edmund Acevedo - eoacevedo@vcu.edu
NCT06874595
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Healthy adults
* aged 18 to 50
* consent and complete a Physical Activity Readiness Questionnaire (PAR-Q)
* be free from any neurological or psychiatric disorder
* not be taking any medication that could affect the central nervous system
* not have any contraindication for HD-tDCS (i.e. not having metal implanted in the head, pacemaker, medical bumps, seizures, lesions on the scalp or head ) or for bioelectrical impedance (i.e., electronic medical implant, such as a pacemaker or implantable cardioverter defibrillator, and limb amputation)
* not be regular users of tobacco products (cigarettes, cigars, chewing tobacco)
* not consume an average of more than ten alcoholic beverages per week
Exclusion Criteria:
* Individuals who do not meet the PAR-Q screening criteria for participation in moderate physical activity will be excluded from participating in this study
* women who are pregnant will be exclude from this study OTHER: Cycling exercise at 65% of HRR for 20 minutes followed by HD-tDCS (exercise + HD-tDCS), OTHER: Cycling exercise at 65% of HRR exercise followed by sham HD-tDCS (exercise + sham tDCS), OTHER: No exercise followed by HD-tDCS (no exercise + HD-tDCS)., OTHER: State Anxiety Inventory, OTHER: Visual Analog Scale for Anxiety
Psychological
Exercise and Brain Stimulation
I'm interested
Share via email
Show 1 location
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Virginia Commonwealth University Richmond, Virginia | Edmund Acevedo, PhD - (eoacevedo@vcu.edu) |
Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Children With ADHD
Joseph T Hull, PhD - jhull@supernus.com
NCT04781140
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
• Is male or female 4 years 0 months of age to less than or equal to 5 years 9 months of age at Visit 1 (Screening) and considered medically healthy.
• Subject's parent(s) or legal guardian(s)/representative(s) is (are) willing and able to provide written informed consent before completing any study related procedures.
• Has a primary diagnosis of ADHD according to DSM-IV-TR criteria and confirmed with the Kiddie Schedule for Affective Disorders and Schizophrenia - Present and Lifetime Version (K-SADS-PL).
• Has an ADHD-RS-IV-P Total Score of ≥ 28 (males) or ≥ 24 (females) at Visit 1 (Screening) and at Visit 2 (Baseline).
• Has a CGI-S score of ≥ 4 (moderate or worse) at Visit 1 (Screening) and at Visit 2 (Baseline).
• Has undergone an adequate course of non-pharmacologic treatment or is having symptoms severe enough to warrant pharmacologic treatment without prior non-pharmacologic treatment.
• Is participating in a structured group activity (e.g., preschool, kindergarten, sports, Sunday school, summer camp or childcare program) at least 2 days a week during study so as to assess symptoms and impairment in a setting outside the home.
• Has not initiated any behavioral intervention/therapy within 30 days of Visit 1 (Screening) and does not plan to initiate any new or discontinue any ongoing behavioral intervention/therapy during the study (e.g., subject is eligible if behavioral intervention/therapy is initiated 30 or more days prior to Visit 1 \[Screening\] and continues with a similar duration/frequency throughout their study).
• Subjects who are on ADHD medication at Visit 1 (Screening), but whose ADHD symptoms are not well controlled on current ADHD medication (e.g., meets Inclusion Criterion #4), meet all other inclusion/exclusion criteria, and discontinues ADHD medication at least 7 days prior to the day of Visit 2 (Baseline) are eligible to participate.
• Has no current condition in the opinion of the Investigator that could confound efficacy assessments, safety assessments or increase participant risk.
• Has lived with the same parent(s) or legal guardian(s) or has lived under a shared living arrangement (e.g., joint legal custody) for greater than or equal to 6 months prior to Visit 1 (Screening).
• Has a body weight ≥5th percentile for age and sex at Visit 1 (Screening) and Visit 2 (Baseline).
Exclusion Criteria:
• Has a diagnosis at Screening (per K-SADS-PL) of another psychiatric disorder that is considered to be the primary diagnosis rather than ADHD or has a comorbid psychiatric disorder secondary to ADHD that, in the opinion of the investigator (after consulting medical monitor), will likely interfere with study treatment adherence and/or impact study results.
• Has a current diagnosis of a major neurological disorder. The eligibility of those who have seizures, a history of seizure-like events (e.g., syncope, myoclonus, severe muscle spasms), a family history of seizure disorder (immediate family, i.e., sibling, parent), and/or febrile seizures will be assessed on a case-by-case basis after consulting the medical monitor.
• History of Bipolar Disorder diagnosed in a first degree relative.
• Has global development delay or intellectual disability by medical history.
• Has a current diagnosis of a significant (per Investigator's evaluation and/or judgement) systemic disease.
• Has body mass index \> 95th percentile for the subject's age and sex at Visit 1 (Screening) or Visit 2 (Baseline).
• Has a mean resting systolic and diastolic blood pressure\* that are both \>95th percentile for age sex, and height and has a mean resting pulse rate\* that is \>95th percentile for age and sex (males: \>117 bpm; females: \>122 bpm) at Visit 1 (Screening) or Visit 2 (Baseline). \* Note: The mean of three measurements while seated.
• Has a clinically significant electrocardiogram finding(s) at Visit 1 (Screening).
• Is currently taking SPN-812 for ADHD, has previously taken SPN-812 for ADHD, but discontinued due to a lack of efficacy or adverse reactions, or has history of allergic reaction, hypersensitivity or intolerance to viloxazine.
• Has an allergy to or cannot swallow pudding and applesauce and cannot swallow intact capsule whole.
• Has any food allergy, intolerance, restriction or special diet that, in the opinion of the Investigator, could contraindicate the subject's participation in the study.
• Has received any investigational drug within the longer of 30 days or 5 half-lives prior to Visit 2 (e.g., first dose of study medication).
• Has a positive urine drug test at Visit 1 (Screening). A positive test for amphetamines is allowed for subjects receiving a stimulant ADHD medication at Screening. The subject will be required to discontinue the stimulant for the duration of the study, beginning at least 7 days prior to Visit 2 (Baseline).
• Is using of prohibited concomitant medications including known CYP1A2 substrates (e.g., theophylline, melatonin) during the Screening Period or (anticipated) for the duration of the study.
• Any reason that, in the opinion of the Investigator, would prevent the subject from participating in the study.
• Has suicidal ideation ("Yes" indicated on C-SSRS question 4 or 5) or suicidal behavior ("Yes" indicated on C-SSRS for any suicidal behavior) within 6 months prior to or the day of Visit 1 (Screening) or has attempted suicide ("Yes" indicated on C-SSRS for lifetime).
DRUG: 100mg SPN-812, DRUG: Placebo
Attention-Deficit/Hyperactivity Disorder
ADHD
I'm interested
Share via email
Show 49 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| AIM Trials Plano, Texas | - (info@aimtrials.com) |
| APG Research LLC Orlando, Florida | - (Mollie@apghealth.com) |
| Accel Research Sites-LKD CRU Lakeland, Florida | - (recruiting@accelclinical.com) |
| Advanced Discovery Research LLC Atlanta, Georgia | - (contact@advdiscovery.com) |
| Advanced Research Center (ARC), Inc. Anaheim, California | - (contact@arctrials.com) |
| Alliance Research Long Beach, California | - (Research@asclepes.com) |
| Avantis Clinical Research LLC Miami, Florida | - (info@avantisclinicalresearch.com) |
| Boston Children's Hospital Boston, Massachusetts | - (leslie.smitley@childrens.harvard.edu) - (ResAdmin@childrens.harvard.edu) |
| CenExcel iResearch, LLC Decatur, Georgia | |
| CenExel iResearch, LLC. Savannah, Georgia | |
| Cincinnati Children's Hospital and Medical Center Cincinnati, Ohio | - (ADHDResearch@cchmc.org) |
| CincyScience West Chester, Ohio | - (research@cincyscience.com) |
| Clinical Integrative Research Center of Atlanta Atlanta, Georgia | |
| Clinical NeuroScience Solutions, Inc. Memphis, Tennessee | |
| Clinical NeuroScience Solutions, Inc. Memphis, Tennessee | |
| Clinical NeuroScience Solutions, Inc. Memphis, Tennessee | |
| Clinical Research Partners, LLC Petersburg, Virginia | |
| Clinical Research of Southern Nevada, LLC. Las Vegas, Nevada | - (kluna.cpbm@gmail.com) |
| Coastal Carolina Research Center North Charleston, South Carolina | - (CCRC@CoastalCarolinaResearch.com) |
| Coastal Pediatric Research Summerville, South Carolina | - (info.research@cpakids.com) |
| Cyn3rgy Research Gresham, Oregon | - (support@cyn3rgy.com) |
| D&H Tamarac Research Center Tamarac, Florida | - (info@dhnrc.com) |
| DelRicht Research Baton Rouge, Louisiana | - (info@delricht.com) |
| DelRicht Research (Touro Medical Center) New Orleans, Louisiana | - (info@delricht.com) |
| Duke University Durham, North Carolina | |
| Family Psych of The Woodlands The Woodlands, Texas | - (info@woodlandspsych.com) |
| Hope Research Network, LLC. Miami, Florida | - (info@hoperesearchnetwork.com) |
| Houston Clinical Trials, LLC. Bellaire, Texas | |
| IMMUNOe Research Centers Centennial, Colorado | - (verosinfo@veroshealth.com) |
| Icahn School of Medicine at Mount Sinai New York, New York | |
| Javara Dallas, Texas | |
| Jersey Shore University Medical Center Neptune City, New Jersey | - (andrew.layman@hmhn.org) |
| Kennedy Krieger Institute Baltimore, Maryland | |
| Kentucky Pediatric/Adult Research Bardstown, Kentucky | - (kpar@kpar.us) |
| Luna Research Center Coral Gables, Florida | |
| Med Clinical Research Irvington, New Jersey | - (info@medclinicalresearch.com) |
| Medical Research Group of Central Florida Orange City, Florida | |
| National Institute of Clinical Research (NICR) Garden Grove, California | |
| Neurobehavioral Medicine Group Bloomfield Hills, Michigan | - (info@neurobmg.com) |
| Penn State Health Milton S. Hershey Medical Center-Investigational Drug Service Pharmacy Hershey, Pennsylvania | - (rmyers12@pennstatehealth.psu.edu) |
| Precise Research Centers Flowood, Mississippi | |
| Preferred Research Partners - NWA, LLC Fayetteville, Arkansas | |
| Preferred Research Partners, Inc. Little Rock, Arkansas | - (info@preferredresearchpartners.com) |
| Qualmedica Research, LLC. Owensboro, Kentucky | |
| Qualmedica Research, LLC. Owensboro, Kentucky | |
| Sarkis Clinical Trials Gainesville, Florida | |
| Sun Valley Research Center Imperial, California | - (svrcinfo@sunvalleyb.com) |
| The Center for Clinical Trials, Inc. Saraland, Alabama | - (info@thecenterforclinicaltrials.com) |
| Virginia Commonwealth University, Virginia Treatment Center for Children Richmond, Virginia |
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
Novartis Pharmaceuticals - novartis.email@novartis.com
NCT05268289
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Unequivocally positive ANA test result and/or a positive anti dsDNA at screening Active biopsy-proven lupus nephritis within 3 months of screening demonstrating Class III or IV lupus nephritis with or without co-existing features of Class V lupus nephritis.
Documentation of active renal disease at the time of screening necessitating the commencement of therapy with corticosteroids in combination with MMF/MPS.
eGFR ≥ 30 ml/min/1.73 m2 Vaccination against Neisseria meningitidis and Streptococcus pneumoniae infections Vaccination against Haemophilus influenzae infection Supportive care including stable dose regimen of anti-malarials (e.g. hydroxychloroquine) unless contraindicated, ACEi or ARB at either locally approved maximal daily dose or the maximally tolerated dose (per investigators' judgement) at screening, as per the local clinical practice. Doses should remain stable throughout the study.
First presentation or flare of lupus nephritis.
Exclusion Criteria:
Induction treatment with cyclophosphamide within 3 months of planned treatment for this study; treatment with calcineurin inhibitors within the previous 3 months prior to randomization.
Presence of rapidly progressive glomerulonephritis (RPGN) as defined by 50% decline in eGFR within 3 months prior to screening.
Renal biopsy presenting with interstitial fibrosis/tubular atrophy (IF/TA) or glomerulosclerosis of more than 50%, or which in the opinion of the investigator is such that it precludes likely response to immunosuppressive therapy.
Participants being treated with systemic corticosteroids (\>5 mg/day prednisone or equivalent) for indications other than SLE or LN e.g. acute asthma, inflammatory bowel disease.
Participants being treated with systemic corticosteroids for SLE or LN will be excluded if they have taken more than an average of 15 mg/day prednisone (or equivalent) in the previous 4 weeks and more than an average of 30 mg/day in the previous 1 week Receipt of more than a total dose of 1000 mg equivalent i.v. pulse methylprednisolone (cumulative dose) within 2 weeks prior to enrollment (and at enrollment)
Other protocol-defined inclusion/exclusion criteria may apply DRUG: Iptacopan (part 1), DRUG: Iptacopan (part 2), DRUG: Placebo + standard of care, DRUG: Iptacopan + placebo
Lupus Nephritis
LNP023, Iptacopan, Lupus Nephritis, proteinuria, Urine Protein-to-Creatinine Ratio, complete renal response, estimated glomerular filtration rate, renal flares, Systemic Lupus Erythematosus
I'm interested
Share via email
Show 104 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| AKDHC Medical Research ServicesLLC Phoenix, Arizona | |
| Allegheny Health Network Pittsburgh, Pennsylvania | |
| Brigham and Womens Hosp Harvard Med School Boston, Massachusetts | Katherine Curtis - (kcurtis2@bwh.harvard.edu) |
| Cleveland Clinic Foundation Cleveland, Ohio | |
| Dallas Nephrology Associates Dallas, Texas | Esmeralda Martinez - (Martinezes@dneph.com) |
| FDI Clinical Research San Juan, | |
| Florida Kidney Physicians Riverview, Florida | |
| Florida Kidney Physicians Riverview, Florida | |
| Johns Hopkins Hospital Baltimore, Maryland | |
| Kaiser Permanente Fontana Fontana, California | Kimberly Cortez - (kimberly.x.cortez@kp.org) |
| Loma Linda University Loma Linda, California | Brenda Delgado - (bdelgado@llu.edu) |
| Mayo Clinic Jacksonville Jacksonville, Florida | Trinity Hooks - (Hooks.Trinity@mayo.edu) |
| Mayo Clinic Rochester Rochester, Minnesota | |
| Nep Assoc of Northern Illinois Hinsdale, Illinois | |
| Nephrology Associates Of Central FL Orlando, Florida | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Novartis Investigative Site London, | |
| Ochsner Health System New Orleans, Louisiana | |
| Olive View UCLA Medical Center Sylmar, California | |
| Prolato Clinical Research Center Houston, Texas | Debbie Era - (dera@prolato.org) |
| Ronald Reagan UCLA Medical Center Los Angeles, California | |
| Royal Research Corp Hollywood, Florida | |
| Stony Brook Internists PC East Setauket, New York | |
| Temple University Philadelphia, Pennsylvania | Zoe Pfeffer - (Zoe.pfeffer@tuhs.temple.edu) |
| Univ Calif Irvine Irvine, California | |
| University of Colorado Denver Aurora, Colorado | |
| University of Nebraska Medical Center Omaha, Nebraska | |
| Virginia Commonwealth University Richmond, Virginia | Olufunso Fasoyiro - (Olufunso.Fasoyiro1@vcuhealth.org) |
| Wichita Community Clcl Onco Program Wichita, Kansas | Joanna Haddad - (jhaddad@wngpa.com) |
The Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART) (AID-HEART)
Benjamin VanTassell - bvantassell@vcu.edu
NCT06062966
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Primary diagnosis for the clinic visit is stage D heart failure being on chronic stable dose of inotrope therapy (dobutamine or milrinone for the previous 28 days)
* Prior documentation of impaired left ventricular systolic function (ejection fraction \<50%) at most recent assessment by any imaging modality (within 12 months)
* Stable dose of inotrope treatment without a recent hospitalization within the previous month
* Age ≥21 years and willing/able to provide written informed consent
* The patient is willing and able to comply with the protocol (i.e. self administration of the treatment, and exercise protocol).
* Screening plasma C-reactive protein levels \>2 mg/L
Exclusion Criteria:
* Concomitant clinically significant comorbidities including (but not limited to) acute coronary syndromes, uncontrolled hypertension or orthostatic hypotension, tachy- or brady-arrhythmias, acute or chronic pulmonary disease or neuromuscular disorders affecting respiration that would interfere with the execution, interpretation, or completion of the study
* Recent (previous 3 months) or planned resynchronization therapy (CRT), or valve surgeries
* Previous or planned implantation of left ventricular assist devices or heart transplant within the next 3 months
* Recent (\<14 days) use of immunosuppressive or anti-inflammatory drugs (including oral corticosteroids at a dose of prednisone equivalent of 0.5 mg/kg/day but not including inhaled or low dose oral corticosteroids or non-steroidal anti-inflammatory drugs)
* Chronic inflammatory disorder (including but not limited to rheumatoid arthritis, systemic lupus erythematosus)
* Active infection (of any type), including chronic/recurrent infectious disease (including HBV, HCV, and HIV/AIDS) - but excluding HCV+ with undetectable plasma RNA
* Prior (within the past 5 years) or current malignancy on targeted treatment - excluding carcinoma in situ \[any location\] or localized non-melanoma skin cancer
* Stage V kidney disease or on renal-replacement therapy
* Neutropenia (\<1,500/mm3 or \<1,000/mm3 in African-American patients)
* Pregnancy or breastfeeding
* Angina, hypertension, arrhythmias, electrocardiograph (ECG) changes, or other non-cardiac limitations that limit 6MWD obtained during the baseline testing
* Hypersensitivity to anakinra or to E. coli derived products DRUG: Anakinra
Heart Failure
Inotrope sensitivity, IL-1 Blockade, Subcutaneous (SC), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV, 6 Minute Walk Test (6MWT)
I'm interested
Share via email
Show 1 location
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Virginia Commonwealth University Richmond, Virginia | Azita Talasazah - (talasazah@vcu.edu) Benjamin Van Tassell - (bvantassell@vcu.edu) |
ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack (ARTEMIS)
Novo Nordisk - clinicaltrials@novonordisk.com
NCT06118281
Show full eligibility criteria
Hide eligibility criteria
Key inclusion:
* Age 18 years or above at the time of signing the informed consent.
* Hospitalisation for acute myocardial infarction with evidence of type 1 myocardial infarction (MI) by invasive angiography performed at site with percutaneous coronary intervention (PCI) capabilities.
* ST-segment elevation myocardial infarction (STEMI) with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 12 hours before hospitalisation, at the investigator's discretion.
b) Electrocardiogram (ECG)-changes (in the absence of left ventricular hypertrophy or left bundle branch block): ST-segment elevation at the J point in at least two contiguous leads greater than or equal 0.25 (millivolt) mV in men less than 40 years, greater than or equal 0.2 mV in men greater than or equal 40 years, or greater than or equal 0.15 mV in women in leads V2-V3; and/or greater than or equal 0.1 mV in all other leads.
OR
* Non-ST-segment myocardial infarction with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 24 hours before hospitalisation, at the investigator's discretion. b) Rise and/or fall in car-diac troponin I or T with at least one value above the 99th percentile upper reference limit.
* Possibility for both randomisation and administration of the loading dose of study intervention as early as possible after invasive procedure, and latest within 36 hours of hospitalisation (time 0) for STEMI, and latest within 72 hours of hospitalisation (time 0) for NSTEMI.
* Presence of at least one of the following criteria confirmed based on the participant's medical records and/or medical history interview: a) Any prior MI. b) Prior coronary revascularisation. c) Diabetes mellitus treated with ongoing glucose-lowering agent(s). d)Known chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) greater than or equal to 15 and less than 60 milliliter per minute per 1.73 square meter (mL/min/1.73 m\^2). e) Prior ischaemic stroke. f) Known carotid disease or peripheral artery disease in the lower extremities. g) Multivessel coronary artery disease (current/prior). h) For STEMI patients only: anterior MI at index acute myocardial infarction (AMI)
Key exclusion:
* Use of fibrinolytic therapy for treatment of the current AMI.
* Chronic heart failure classified as being in New York Heart Association (NYHA) Class IV.
* Ongoing haemodynamic instability defined as any of the following: a) Killip Class III or IV. b) Sustained and/or symptomatic hypotension (systolic blood pressure less than 90 millimeters of mercury (mmHg)).
* Severe kidney impairment defined as any of the following: a) eGFR less than 15 mililitre per minute per 1.73 m\^2. b) Chronic haemodialysis or peritoneal dialysis.
* Known alanine aminotransferase (ALT) greater than 8 x upper limit of normal (reference range) (ULN).
* Severe hepatic disease defined as at least one of the following: a) Previously known or current hepatic encephalopathy (clinical evaluation). b) Previously known or current ascites (clinical eval-uation). c) Jaundice (clinical evaluation). d) Previous oesophageal/gastric variceal bleeding. c) Known hepatic cirrhosis.
* Major cardiac surgical (including but not restricted to coronary artery bypass graft surgery (CABG)), non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days or any major surgical procedure planned at the time of randomisation or as treatment for the current AMI (CABG). Deferred (staged)percutaneous coronary intervention for a non-culprit vessel identified during the current AMI is allowed.
* Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
* Known (acute or chronic) hepatitis B or hepatitis C.
* History or evidence of untreated latent tuberculosis (TB) such as (but not limited to): a) History of a positive TB test or chest X-ray compatible with latent TB; and TB treatment initiated less than 28 days prior to randomisation. b) Participants with TB risk factors but unwilling to undergo TB treatment if confirmed positive for latent TB based on central laboratory test at baseline (visit 2).
DRUG: Ziltivekimab, DRUG: Placebo
Cardiovascular Risk, Acute Myocardial Infarction (AMI)
I'm interested
Share via email
Show 873 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| "AHEPA" University General Hospital of Thessaloniki Thessaloniki, | |
| "AHEPA" University General Hospital of Thessaloniki Thessaloniki, | |
| "Hygeia" General Hospital of Athens Athens, | |
| "MHAT - Pazardzhik" Pazardzhik, | |
| "Sotiria" Thoracic Diseases Hospital of Athens Athens, | |
| "UMHAT "Aleksandrovska" EAD, Cardiology clinic Sofia, | |
| "UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology Sofia, | |
| "UMHAT-Burgas" Burgas, | |
| "UMHATEM N.I. Pirogov" EAD Sofia, | |
| 'G. Gennimatas' General Hospital of Athens Athens, | |
| 'G. Gennimatas' General Hospital of Athens Athens, | |
| 'MHAT Hadzhi Dimitar' OOD Sliven, | |
| 'MHAT Sveta Karidad' EAD Plovdiv, | |
| 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ Lublin, | |
| 10 Wojskowy Szpital Kliniczny z Polikliniką - Samodzielny Publiczny Zakład Opieki Zdrowotnej w Bydgoszczy Bydgoszcz, | |
| 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu Wroclaw, Lower Silesian Voivodeship | |
| A.O.U Città della Salute e della Scienza di Torino Torino, | |
| A.O.U Città della Salute e della Scienza di Torino Torino, | |
| A.O.U. Ferrara, Sant'Anna Cona (Ferrara), Fe | |
| AORN "Sant'Anna e San Sebastiano" Caserta, Ce | |
| AOU Maggiore della Carità di Novara - Dipartimento Toraco-Cardio-Vascolare - SCDU Cardiologia Novara, | |
| AOUI Verona Verona, | |
| ASSOCIAÇÃO LAR SÃO FRANCISCO DE ASSIS NA PROVIDÊNCIA DE DEUS - Hospital Regional de Presidente Prudente Presidente Prudente, São Paulo | |
| AUSL Romagna - Distretto Rimini - Ospedale Infermi Rimini, | |
| Aakash Healthcare Super Speciality Hospital New Delhi, | |
| Aalborg Universitetshospital Kardiologisk Afdeling Aalborg, | |
| Aalborg Universitetshospital Kardiologisk Afdeling Aalborg, | |
| Aarhus Universitetshospital, Hjertesygdomme Aarhus N, | |
| Abbott Northwestern Hospital Minneapolis, Minnesota | |
| Acibadem City Clinic UMHAT EOOD Sofia, | |
| Acibadem City Clinic UMHAT Tokuda EAD Sofia, | |
| Advanced Cardiovascular, LLC Alexander City, Alabama | |
| Advanced Heart & Vein Center Thornton, Colorado | |
| Advanced Heart Care LLC Bridgewater, New Jersey | |
| Adventist Healthcare Shady Grove Medical Center Rockville, Maryland | |
| Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji Afyonkarahisar, | |
| Ajou University Hospital Suwon, Gyeonggi-do | |
| Akdeniz University Medical Faculty Antalya, | |
| Alexandra General Hospital, Therapeutic Clinic Athens, | |
| All India Institute of Medical Sciences (AIIMS) New Delhi, National Capital Territory of Delhi | |
| All India Institute of Medical Sciences (AIIMS) New Delhi, National Capital Territory of Delhi | |
| All India Institute of Medical Sciences (AIIMS), Bhubaneswar Bhubaneswar, Odisha | |
| All India Institute of Medical Sciences (AIIMS), Nagpur Nagpur, Maharashtra | |
| American Heart of Poland S.A. Zgierz, | |
| American Heart of Poland S.A. Zgierz, | |
| American Heart of Poland S.A. Zgierz, | |
| American Heart of Poland S.A. Zgierz, | |
| American Heart of Poland S.A. Zgierz, | |
| American Heart of Poland S.A. Zgierz, | |
| American Heart of Poland S.A. Zgierz, | |
| American Heart of Poland S.A. Zgierz, | |
| Amper Kliniken AG - Helios Amper-Klinikum Dachau - Kardiologie Dachau, | |
| Amphia Ziekenhuis Breda, | |
| AnMed Health Clinical Research Anderson, South Carolina | |
| Ankara Sehir Hastanesi Cardiology Ankara, | |
| Ankara University Medical Faculty Ankara, | |
| Antalya İl Sağlık Müdürlüğü Antalya EAH Muratpasa/ Antalya, | |
| Ap-Hp-Hopital Bichat-Claude Bernard-1 Paris, | |
| Ap-Hp-Hopital Europeen Georges Pompidou Paris, | |
| Aphp-Hopital La Pitie Salpetriere-1 Paris, | |
| Apollo Multispeciality Hospital, Kolkata Kolkata, West Bengal | |
| Arcispedale S Maria Nuova Azienda ULSS-IRCCS Reggio Emilia, | |
| Arkansas Cardiology Clinic Little Rock, Arkansas | |
| Arneja Heart & Multispeciality Hospital Nagpur, Maharashtra | |
| Asahi General Hospital＿Cardiology Chiba, | |
| Asan Medical Center Seoul, | |
| Ascension Sacred Heart Pensacola, Florida | |
| Ascension St. Mary's Research Institute - Michigan Southfield, Michigan | |
| Asklepieion General Hospital Athens/Voula, | |
| Asklepios Klinik Langen - Medizinische Klinik I Langen, | |
| Assistance Publique Hopitaux de Marseille-Hopital de La Timone-1 Marseille, | |
| Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista Bragança Paulista, São Paulo | |
| Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital New Delhi, National Capital Territory of Delhi | |
| Atlanta VAMC Decatur, Georgia | |
| AtlantiCare Regional Medi Cnt Pomona, New Jersey | |
| Augusta University Augusta, Georgia | |
| Augusta University Augusta, Georgia | |
| Aultman Hospital Canton, Ohio | |
| Aurora St. Luke's Medi Ctr Milwaukee, Wisconsin | |
| Austin Health Heidelberg, Victoria | |
| Austin Heart Austin, Texas | |
| Azienda Ospedaliera Santa Maria Degli Angeli Pordenone, PN | |
| Azienda Ospedaliera Universitaria Careggi Florence, Tuscany | |
| Azienda Ospedaliera Universitaria Federico II di Napoli Napoli, | |
| Azienda Ospedaliera di Parma Parma, | |
| Azienda Ospedaliera di Parma Parma, | |
| Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli Napoli, | |
| Azienda Ospedaliero - Universitaria Sant'Andrea Rome, | |
| Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara Novara, | |
| Azienda Ospedaliero-Universitaria Renato Dulbecco Catanzaro, Cz | |
| Azienda Ospedaliero-Universitaria SS Antonio e Biagio e Cesare Arrigo Alessandria, | |
| Azienda Sanitaria Friuli Occidentale - Azienda Ospedaliera Santa Maria Degli Angeli - SC Cardiologia Pordenone Pordenone, PN | |
| Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia Torino, To | |
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Bergamo, Lombardy | |
| Azienda Unità Sanitaria Locale Di Piacenza - Cardiologia Piacenza, | |
| B M Birla Heart Research Centre Kolkata, West Bengal | |
| B M Birla Heart Research Centre Kolkata, West Bengal | |
| BG Klinikum Unfallkrankenhaus Berlin GmbH - Klinik für Kardiologie Berlin, | |
| Baptist Clin Res Institute Memphis, Tennessee | |
| Baptist Heart Specialists Jacksonville, Florida | |
| Baptist Hospital Cardiology Pensacola, Florida | |
| Barts Heart Centre London, | |
| Barts Heart Centre London, | |
| Barwon Health (The Geelong Hospital) Geelong, Victoria | |
| Batra Hospital and Medical Research Center New Delhi, National Capital Territory of Delhi | |
| Baylor Scott & White Res Inst Plano, Texas | |
| Beijing Anzhen Hospital, Capital Medical University Beijing, Beijing Municipality | |
| Bellvitge Universitary Hospital Badalona, | |
| Birmingham VA Medical Center Birmingham, Alabama | |
| Blackpool Victoria Hospital Blackpool, | |
| Bon Secours St. Mary's Hospital of Richmond, LLC Richmond, Virginia | |
| Bravis Ziekenhuis Roosendaal, | |
| Bremer Institut für Herz- und Kreislaufforschung (BIHKF) Bremen, | |
| Bridgeport Hospital Bridgeport, Connecticut | |
| Brigham & Women's Hospital Boston, Massachusetts | |
| Bursa Yüksek İhtisas Eğitim ve Araştırma Merkezi-Kardiyoloji Bursa, | |
| Bursa Şehir Hastanesi- Kardiyoloji Bursa, | |
| CHU de Quebec-Universite-Laval,HDQ Québec, | |
| CHUM Centre de Recherch Hotel-Dieu Montreal, Quebec | |
| CHUM Centre de Recherch Hotel-Dieu Montreal, Quebec | |
| CIP Centro Integrado de Pesquisas do Hospital de Base São José do Rio Preto, São Paulo | |
| CIP Centro Integrado de Pesquisas do Hospital de Base São José do Rio Preto, São Paulo | |
| CISSS de Lanaudiere - Centre hospitalier De Lanaudiere Saint-Charles-Borromée, Quebec | |
| CISSSL Hôsp Pierre-Le Gardeur Terrebonne, Quebec | |
| CIUSS Hopit de Chicoutimi Chicoutimi, Quebec | |
| CV Research of Knoxville Powell, Tennessee | |
| Cairns Base Hospital Cairns, Queensland | |
| Cangzhou Central Hospital Cangzhou Shi, Hebei | |
| Canisius-Wilhelmina ziekenhuis Nijmegen, | |
| Cardio. Consult. of S. GA Thomasville, Georgia | |
| Cardiolg Assoc Rsch LLC_Tupelo Tupelo, Mississippi | |
| Cardiology Associates of Fairfield County Stamford, Connecticut | |
| Cardiology Associates_Asheville Asheville, North Carolina | |
| Cardiología Hospital J. M. Ramos Mejia Buenos Aires, | |
| Cardiovascular Associates of the Delaware Valley Vineland, New Jersey | |
| Catharina Ziekenhuis Eindhoven Eindhoven, | |
| Cellitinnen-Krankenhaus St. Vinzenz Köln - Kardiologie Cologne, | |
| Central Arkansas Veteran's Healthcare System Little Rock, Arkansas | |
| Central India Cardiology Hospital and Research Institute Nagpur, Maharashtra | |
| Centre Hospitalier Regional Universitaire de Tours-Hopital Trousseau Chambray-lès-Tours, | |
| Centre Hospitalier Saint Joseph Saint Luc Lyon, | |
| Centre Hospitalier Sud Francilien Corbeil-Essonnes, | |
| Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-1 Grenoble, | |
| Centre Hospitalier Universitaire de Besancon-Hopital Jean Minjoz Besançon, | |
| Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque-1 Pessac, | |
| Centre Hospitalier Universitaire de Caen Normandie- Cote de Nacre-1 Caen, | |
| Centre Hospitalier Universitaire de Lille-Institut Coeur Poumon Lille, | |
| Centre Hospitalier Universitaire de Nice-Hopital Pasteur Nice, | |
| Centre Hospitalier Universitaire de Poitiers Poitiers, | |
| Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1 Toulouse, | |
| Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1 Toulouse, | |
| Centre hosp affilié univ rég Trois-Rivières, Quebec | |
| Centro Médico Nacional Siglo XXI Mexico City, | |
| Centro Privado de Cardiología San Miguel de Tucuimán, Tucumán Province | |
| Centro de Estudios Clinicos de Querétaro S.C. Querétaro, | |
| Centro de Estudios Clinicos de Querétaro S.C. Querétaro, | |
| Centro de Imagen y Tecnologia en Intervención Cardiovascular México, La Magdalena Contreras | |
| Centro de Investigación C.I.C.E 9 de Julio - Sanatorio 9 de Julio San Miguel de Tucumán, Tucumán Province | |
| Centro de Pesquisa Clínica do Hospital de Clínicas da Universidade Federal de Uberlândia Uberlândia, Minas Gerais | |
| Centro de atención e investigación cardiovascular del Potosí San Luis Potosí City, | |
| Cerrahpaşa Kardiyoloji Enstitüsü Istanbul, | |
| Chambersburg Hospital Chambersburg, Pennsylvania | |
| Charité - Campus Benjamin Franklin - Klinik für Kardiologie Berlin, | |
| Chattanooga Heart Institute Chattanooga, Tennessee | |
| Chattanooga Heart Institute Chattanooga, Tennessee | |
| China-Japan Friendship Hospital Beijing, | |
| China-Japan Friendship Hospital Beijing, | |
| China-Japan Union Hospital of Jilin University Changchun, Jilin | |
| China-Japan Union Hospital of Jilin University-Cardiology Changchun, Jilin | |
| Chinese Academy of Medical Sciences Fuwai Hospital Beijing, Beijing Municipality | |
| Chippenham Medical Center Richmond, Virginia | |
| Chonnam National University Hospital Gwangju, | |
| Chopda Medicare and Research Centre Pvt. Ltd. Nashik, Maharashtra | |
| Christiana Care Health Services, Inc. Newark, Delaware | |
| Christus Heart and Vascular Institute Tyler, Texas | |
| Chru de Nancy - Hopital Brabois Vandœuvre-lès-Nancy, | |
| Chungbuk National University Hospital Chungju, | |
| Chungnam National University Hospital Daejeon, | |
| Chungnam National University Sejong Hospital Sejong-si, | |
| Cleveland Clinic_Cleveland Cleveland, Ohio | |
| Clínica Privada Velez Sarsfield Córdoba, | |
| Clínica Privada Velez Sarsfield Córdoba, | |
| Complejo Hospitalario Universitario A Coruna A Coruña, | |
| Concord Repatriation General Hospital - Cardiology Department Concord, New South Wales | |
| Copernicus Podmiot Leczniczy Sp. z o.o. Gdansk, | |
| Corewell Health Grand Rapids, Michigan | |
| Dallas VA Medical Center Dallas, Texas | |
| Danbury Hospital - Cardiology Department Danbury, Connecticut | |
| Dartmouth-Hitchcock Med Ctr Lebanon, New Hampshire | |
| Dayanand Medical College & Hospital Ludhiana, Punjab | |
| Deenanath Mangeshkar Hospital & Research Centre Pune, | |
| Deenanath Mangeshkar Hospital & Research Centre Pune, | |
| Denver Health Medical Center Denver, Colorado | |
| Derriford Hospital Plymouth, | |
| Deutsches Herzzentrum TU München - Klinik für Herz- und Kreislauferkrankungen München, | |
| Dolnoslaski Szpital Specjalistyczny Im. T.Marciniaka-Centrum Medycyny Ratunkowej Wroclaw, | |
| Dr. Ram Manohar Lohia Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Dr. Ram Manohar Lohia Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Dr. Siyami Ersek Gogus Kalp ve Damar Cerrahisi EAH Istanbul, | |
| Duke University Medical Center Durham, North Carolina | |
| ESIC Medical College and Hospital, Hyderabad Hyderabad, Telangana | |
| Eastern Shore Rsrch Inst, LLC Fairhope, Alabama | |
| Ehime Prefectural Central Hosp Ehime, | |
| Elisabeth-TweeSteden Ziekenhuis Tilburg, | |
| Emory University Hospital Atlanta, Georgia | |
| Endeavor Health Glenbook Hosp Evanston, Illinois | |
| Ente Ecclesiastico Ospedale Generale Regionale Miulli - Cardiologia e UTIC Acquaviva delle Fonti, | |
| Erciyes University Cardiology Kayseri, | |
| Eskisehir Osmangazi University Sağlık Uygulama ve Arastirma Eskişehir, Odunpazari | |
| Eskisehir Sehir Hospital Odunpazarı /Eskişehir, | |
| Essentia Health Duluth, Minnesota | |
| Evangelismos Hospital Athens, | |
| Ewha Womans University Seoul Hospital Seoul, | |
| FN u Sv. Anny Brno, | |
| Fairview Health Services Maplewood, Minnesota | |
| Fairview Health Services Maplewood, Minnesota | |
| Fakultni nemocnice Brno Brno, | |
| Fakultni nemocnice Kralovske Vinohrady Prague, Praha 10 | |
| Fakultni nemocnice Olomouc Olomouc, Olomoucký kraj | |
| Fakultni nemocnice Plzen - Lochotin Plzen - Lochotín, | |
| Flinders Medical Centre Bedford PK, South Australia | |
| Fondazione IRCCS Policlinico San Matteo Pavia, | |
| Fondazione IRCCS San Gerardo dei Tintori Monza, | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCS Roma, | |
| Fondazione Policlinico Universitario Agostino Gemelli Irccs Roma, | |
| Fortis Escorts Heart Institute, New Delhi New Delhi, National Capital Territory of Delhi | |
| Fortis Hospital, Mohali Mohali, Punjab | |
| Frankston Hospital Frankston, Victoria | |
| Freeman Hospital, Newcastle Newcastle upon Tyne, | |
| Fujita Health University Hospital_Cardiology Aichi, | |
| Fukuoka University Hospital_Cardiology Fukuoka-shi, Fukuoka, | |
| Fundacion Favaloro CABA, Buenos Aires, Argentina | |
| Fundación Nuestra Señora del Rosario - Estudios Clínicos los Arroyos San Nicolás de los Arroyos, Buenos Aires | |
| G B Pant Institute of Postgraduate Medical Education and Research New Delhi, National Capital Territory of Delhi | |
| G. Kuppuswamy Naidu Memorial Hospital Coimbatore, Tamil Nadu | |
| G. Kuppuswamy Naidu Memorial Hospital Coimbatore, Tamil Nadu | |
| G.H. of Athens "Evaggelismos" Athens, | |
| Gachon University Gil Medical Center Incheon, | |
| Ganesh Shankar Vidyarthe Memorial (GSVM) Medical College Kanpur, Uttar Pradesh | |
| Gangdong Kyung Hee University Hospital Seoul, | |
| Geisinger Medical Center Danville, Pennsylvania | |
| Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt Thessaloniki, | |
| General Hospital Of Eleusina Thriasio Eleusina, | |
| General Hospital of Athens "Elpis" Ampelokipoi/Athens, | |
| General Hospital of Athens "Laiko" Goudi, Athens, | |
| General Hospital of Chios "Skilitsio" Chios, | |
| General Hospital of Imathia Monada Veria Véroia, | |
| General Hospital of Imathia Monada Veria Véroia, | |
| General Hospital of Patras Agios Andreas Pátrai, | |
| General Hospital of Thessaloniki PAPAGEORGIOU Nea Efkarpia, Thessaloniki | |
| General Hospital of Tianjin Medical University-Endocrinology Tianjin, Tianjin Municipality | |
| Genesis Health Care System Zanesville, Ohio | |
| Glenfield Hospital Leicester, | |
| Gold Coast University Hosptial Southport, Queensland | |
| Golden Jubilee University National Hospital Glasgow, | |
| Grande Ospedale Metropolitano Niguarda Milan, | |
| Grandview Medical Center Birmingham, Alabama | |
| Grey Nuns Community Hospital Edmonton, Alberta | |
| Groene Hart Ziekenhuis, locatie Bleuland Gouda, | |
| Group Euroclinic - Athens Euroclinic Athens, | |
| Guangdong Provincial People's Hospital Guangzhou, | |
| Guangdong Provincial People's Hospital Guangzhou, | |
| HCA Research Institute McAllen, Texas | |
| Hackensack Meridian Health Hackensack, New Jersey | |
| Hadassah Ein Karam MC - Cardio Department Jerusalem, | |
| Hadassah Mount Scorpus MC - Cardiology department Jerusalem, | |
| Hamilton Health Sciences Corp, Ontario Hamilton, Ontario | |
| Hanaoka Seishu Memorial Hosp._Cardiovascular Medicine Hokkaido, | |
| Hanaoka Seishu Memorial Hospital Hokkaido, | |
| Hanyang University Seoul Hospital Seoul, | |
| Health Sciences North Rsrch Inst Greater Sudbury, Ontario | |
| Heart & Vascular Inst._Titus Mount Pleasant, Texas | |
| Heart Center Rsrch_Hunstville Huntsville, Alabama | |
| Hebei General Hospital Shijiazhuang, Hebei | |
| Helios Klinikum Erfurt GmbH - 3. Med. Klinik - Kardiologie Erfurt, | |
| Henry Dunant Hospital Center Athens, | |
| Heritage Medical Research Clinic Calgary, Alberta | |
| Herlev og Gentofte Hospital Hellerup, Capital Region | |
| Hermosillo Heart Team Hermosillo, Sonora | |
| Hillel Yafe MC - Cardiology Department Hadera, | |
| Hippokration Hospital Athens, | |
| Holy Cross Hospital Fort Lauderdale, Florida | |
| Holy Name Medical Center Teaneck, New Jersey | |
| Honor Health Scottsdale, Arizona | |
| Hopital Sacre-Coeur de Montreal Montreal, Quebec | |
| Hospices Civils de Lyon- Hopital Louis Pradel-1 Bron, | |
| Hospital Agamenon Magalhães Recife, Pernambuco | |
| Hospital Alvaro Cunqueiro de Vigo Vigo, | |
| Hospital Angeles de Culiacan Culiacán, Sinaloa | |
| Hospital Angeles de Xalapa Xalapa, Veracruz | |
| Hospital Angeles de las Lomas México, State of Mexico | |
| Hospital Canselor Tuanku Muhriz UKM Cheras, | |
| Hospital Cardiologica Aguascalientes Aguascalientes, Aguascalientes | |
| Hospital Civil De Guadalajara Fray Antonio Alcalde Guadalajara, Jalisco | |
| Hospital Clinic i Provincial Barcelona, | |
| Hospital Clinico San Carlos Madrid, | |
| Hospital Clinico Universitario de Valencia Valencia, | |
| Hospital Clinico Universitario de Valladolid Valladolid, | |
| Hospital Clinico Virgen de la Victoria Málaga, | |
| Hospital Clinico de Santiago Santiago de Compostela, | |
| Hospital De La Santa Creu I Sant Pau Barcelona, | |
| Hospital Del Mar Barcelona, | |
| Hospital Del Mar Barcelona, | |
| Hospital Dr. Jose Maria Cullen Santa Fe, | |
| Hospital Espanol De Mendoza Godoy Cruz, Mendoza Province | |
| Hospital General Universitario Dr. Balmis Alicante, | |
| Hospital General Universitario Dr. Balmis Alicante, | |
| Hospital General de Mexico (HGM) Cuauhtémoc, México, D.F. | |
| Hospital Germans Trias I Pujol Badalona, | |
| Hospital Germans Trias I Pujol Badalona, | |
| Hospital Gregorio Maranon Madrid, | |
| Hospital Gregorio Maranon Madrid, | |
| Hospital Israelita Albert Einstein Morumbi, São Paulo | |
| Hospital Italiano Buenos Aires, | |
| Hospital Italiano de la Plata La Plata, Buenos Aires | |
| Hospital Juárez de Mexico Ciudad de México, D.F., | |
| Hospital Maternidade e Pronto Socorro Santa Lucia Poços de Caldas, Minas Gerais | |
| Hospital Mãe de Deus - Porto Alegre Porto Alegre/RS, | |
| Hospital Pulau Pinang George Town, | |
| Hospital Queen Elizabeth II Sabak Bernam, | |
| Hospital Raja Perempuan Zainab II Kelantan, | |
| Hospital Raja Permaisuri Bainun Ipoh Ipoh, Perak | |
| Hospital Ramon Y Cajal Madrid, | |
| Hospital Ruy Azeredo Ltda Goiânia, Goiás | |
| Hospital Serdang Kajang, Selangor | |
| Hospital Serdang Kajang, Selangor | |
| Hospital Sultanah Aminah Johor Bahru, Johor | |
| Hospital Sultanah Bahiyah Alor Setar, Kedah, | |
| Hospital São Lucas - PUC/RS Porto Alegre, Rio Grande do Sul | |
| Hospital Tengku Ampuan Afzan Kuantan, Pahang | |
| Hospital Univ. Virgen de la Arrixaca El Palmar, Murcia | |
| Hospital Universitari Joan XXIII Tarragona, | |
| Hospital Universitari Joan XXIII Tarragona, | |
| Hospital Universitario Austral Pilar, | |
| Hospital Universitario Austral Pilar, | |
| Hospital Universitario Dr. Jose Eleuterio Gonzalez Monterrey, Nuevo León | |
| Hospital Universitario La Paz Madrid, | |
| Hospital Universitario Marqués de Valdecilla Santander, | |
| Hospital Universitario Virgen del Rocio Seville, | |
| Hospital Universitario de La Princesa Madrid, M | |
| Hospital Universiti Kebangsaan Malaysia Kuala Lumpur, | |
| Hospital Universiti Sains Malaysia_Kota Bharu, Kelantan Kota Bharu, Kelantan, | |
| Hospital Virgen de la Arrixaca El Palmar, Murcia | |
| Hospital das Clínicas da Universidade Federal do Triangulo Mineiro Uberaba, Minas Gerais | |
| Hospital de Lleida "Arnau de Vilanova" Lleida, | |
| Hospital del Centenario Rosario, Santa Fe, | |
| Hospital do Coração do Brasil Brasília, Federal District | |
| Houston Medical Center Houston, Texas | |
| Houston Medical Center Houston, Texas | |
| Houston Methodist Hospital Houston, Texas | |
| Huashan Hospital Fudan University Shanghai, | |
| Huashan Hospital Fudan University Shanghai, | |
| Hyogo Medical University Hospital_Cardiovascular Medicine Hyōgo, | |
| Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology Himeji-shi, Hyogo, | |
| ICOT Istituto Marco Pasquali - UOC Cardiologia Latina, | |
| II. interni klinika VFN - Kardiologie a angiologie Prague, | |
| IKEM Prague, | |
| IRCCS Policlinico San Donato San Donato Milanese, MI | |
| Ikazia Ziekenhuis Rotterdam, | |
| Illawarra Heart Health Centre Wollongong, New South Wales | |
| Indiana University Health Methodist Hosptial Indianapolis, Indiana | |
| Indraprastha Apollo Hospital, New Delhi New Delhi, National Capital Territory of Delhi | |
| Inha University Hospital Incheon, | |
| Inje University Haeundae Paik Hospital Busan, | |
| Inova Fairfax Medical Campus Falls Church, Virginia | |
| Ins Uni de Cardi et de PNA de Québec, | |
| Inspira Health Mullica Hill, New Jersey | |
| Instituto Cardiovascular Buenos Aires CABA, Buenos Aires | |
| Instituto Dante Pazzanese de Cardiologia São Paulo, | |
| Instituto Nacional de Cardiologia Ignacio Chavez Mexico City, | |
| Instituto Nacional de Ciencias Medicas y Nutricion Tlalpan, Mexico City | |
| Instituto de Cardiología de Corrientes Corrientes, | |
| Instituto de Pesquisa Clinica de Campinas Campinas, São Paulo | |
| Integral Pesquisa e Ensino Votuporanga, | |
| Integral Pesquisa e Ensino Votuporanga, | |
| Interbalkan Medical Center of Thessaloniki Thessaloniki, | |
| Intercard Spolka z ograniczona odpowiedzialnoscia Pińczów, | |
| Intercard Spolka z ograniczona odpowiedzialnoscia Pińczów, | |
| Intercoastal Medical Group Sarasota, Florida | |
| Intercoastal Medical Group Sarasota, Florida | |
| Intermountain Medical Center Murray, Utah | |
| Interventional Cardiology Medical Group West Hills, California | |
| Irmandade Santa Casa de Misericórdia de Passos Passos, Minas Gerais | |
| Irmandade da Santa Casa de Misericordia de Porto Alegre Porto Alegre, | |
| Irmandade da Santa Casa de Misericórdia de Marília Marília, São Paulo | |
| Ishikawa Prefectural Central Hospital_Cardiology Ishikawa, | |
| Ishikiriseiki Hospital_Circulatory Medicine Osaka, | |
| Istanbul University Cerrahpasa Medical Faculty Istanbul, | |
| Jackson Heart Clinic Jackson, Mississippi | |
| Jacobi Medical Center The Bronx, New York | |
| Jadestone Clinical Research, LLC Silver Spring, Maryland | |
| Japanese Red Cross Fukuoka Hospital_Cardiology Fukuoka, | |
| Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry, Tamil Nadu | |
| Jawaharlal Nehru Medical College and Hospital Aligarh, Uttar Pradesh | |
| Jawaharlal Nehru Medical College and Hospital Aligarh, Uttar Pradesh | |
| Jeroen Bosch Ziekenhuis 's-Hertogenbosch, | |
| Jersey City Med Center Jersey City, New Jersey | |
| Jinan Central Hospital Affiliated to Shandong University Jinan, Shandong | |
| Jmf Clínica Do Coração Ltda Aracaju, | |
| Juntendo University Shizuoka Hospital Izunokuni-shi, Shizuoka, | |
| Justice K S Hegde Charitable Hospital Mangaluru, Karnataka | |
| KAT General Hospital of Attica Kifissia, | |
| Kagawa Prefectural Central Hospital, Cardiovascular Medicine Takamatsu-shi, Kagawa, | |
| Kaiser Permanente Viewridge Medical Offices San Diego, California | |
| Kanto Rosai Hospital_Cardiology Kanagawa, | |
| Kaplan MC - Cardiac Intensive Care Rehovot, | |
| Kardiologisk Odense & Svendborg Svendborg, | |
| Kartal Kosuyolu Yuksek Ihtisas EAH Istanbul, | |
| Kasturba Medical College and Hospital, Manipal Udupi, Karnataka | |
| Kath. St. Paulus GmbH - St Johannes Hospital Dortmund - Kardiologie Dortmund, | |
| Kayseri City Hospital Kayseri, | |
| Kayseri City Hospital Kayseri, | |
| Keimyung University Dongsan Hospital Daegu, | |
| Kelowna Cardiology Res. Ltd. Kelowna, British Columbia | |
| Kettering General Hospital Kettering, | |
| Kettering Medical Center Kettering, Ohio | |
| King George Hospital Visakhapatnam, Andhra Pradesh | |
| King George's Medical University (KGMU) Lucknow, Uttar Pradesh | |
| King George's Medical University (KGMU) Lucknow, Uttar Pradesh | |
| Kings College Hospital London, | |
| Kings College Hospital London, | |
| Kingston General Hospital Kingston, Ontario | |
| Kliniczny Szpital Wojewodzki nr 2 im. Sw. Jadwigi Krolowej w Rzeszowie Rzeszów, | |
| Klinikum Friedrichshafen GmbH - Klinik für Kardiologie, Angiologie, Pneumologie und internistische Intensivmedizin Friedrichshafen, | |
| Klinikum Fulda gAG - Med. Klinik I Fulda, | |
| Klinikum Leverkusen gGmbH - Med. Klinik 1 Leverkusen, | |
| Knoxville Heart Group Knoxville, Tennessee | |
| Kocaeli University Medical Faculty İzmit, | |
| Konstantopouleio G.H. of Athens, "Agia Olga" Athens, | |
| Korea University Anam Hospital Seoul, | |
| Korea University Guro Hospital Seoul, | |
| Krajska zdravotni, a.s. - Masarykova nemocnice v Usti nad Labem, o.z. Ústní Nad Labem, Czechia | |
| Krajská nemocice Liberec, a.s Liberec, | |
| Krajská nemocnice T.Bati a.s. Zlín, | |
| Kyunghee University Medical Center Seoul, | |
| Kyungpook National University Hospital Daegu, | |
| Kütahya Sağlık Bilimleri Üniversitesi Evliya Çelebi Research and Training hospital Kütahya, | |
| Kütahya Şehir Hastanesi Kütahya, | |
| LA BioMed Harbor UCLA Med Cenr Torrance, California | |
| Lakshmi Hospital Palakkad, Kerala | |
| Lalitha Super Specialities Hospital Guntur, Andhra Pradesh | |
| Les Hopitaux de Chartres-Hopital Louis Pasteur Le Coudray, | |
| Lincoln County Hospital Lincoln, | |
| Lindner Center,Christ Hospital Cincinnati, Ohio | |
| Lisie Hospital Kochi, Kerala | |
| Lister Hospital Stevenage, | |
| Liver Ins@ Mthdist DTX Med Cen Dallas, Texas | |
| Liverpool Heart & Chest Hospital Liverpool, | |
| Liverpool Hospital Liverpool, | |
| Liverpool Hospital Liverpool, | |
| Loma Linda University Faculty Medical Clinics Loma Linda, California | |
| London Health Sciences Center Ontario London, Ontario | |
| Louis Stokes Clvlnd VA Med Ctr Cleveland, Ohio | |
| Lyell McEwin Hospital Elizabeth Vale, South Australia | |
| MHAT "Dr. Bratan Shukerov" Smolyan, | |
| MHAT "Dr. Bratan Shukerov" Smolyan, | |
| MHAT "Puls" AD Cardiology Department Blagoevgrad, | |
| MHAT - Dr. Atanas Dafovski AD Kardzhali, | |
| MHAT Haskovo AD Haskovo, | |
| MHAT Heart and Brain Pleven, | |
| MHAT Heart and Brain EAD Burgas, | |
| MHAT MC-Sv Ivan Rilski EOOD Plovdiv, | |
| MHAT Southwest Hospital OOD Sandanski, | |
| MVZ CCB Frankfurt Und Main-Taunus GbR Frankfurt, | |
| Maasstad Ziekenhuis Rotterdam, | |
| Maine Medical Center Bramhall Portland, Maine | |
| Malla Reddy Narayana Multispeciality Hospital Hyderabad, Telangana | |
| Malla Reddy Narayana Multispeciality Hospital Hyderabad, Telangana | |
| Marengo CIMS Hospital Ahmedabad, Gujarat | |
| Marmara University Medical Faculty Istanbul, | |
| Matsuyama Red Cross Hospital_Department of Cardiovascular Medicine Ehime, | |
| Max Super Speciality Hospital, Saket New Delhi, National Capital Territory of Delhi | |
| Mayo Clinic Arizona Phoenix, Arizona | |
| Mayo Clinic Jacksonville Jacksonville, Florida | |
| McGuire VA Medical Center Richmond, Virginia | |
| McLaren Bay Region Bay City, Michigan | |
| McLaren Greater Lansing Lansing, Michigan | |
| McLaren Macomb Health Care Mount Clemens, Michigan | |
| McLaren Northern MI Hosp Petoskey, Michigan | |
| Meander Medisch Centrum Amersfoort, | |
| MedStar Hlth Res Institute Clinton, Maryland | |
| MedStar Hlth Res Institute Clinton, Maryland | |
| Medical College & Hospital, Kolkata Kolkata, West Bengal | |
| Medical College & Hospital, Kolkata Kolkata, West Bengal | |
| Medicover Hospitals, Visakhapatnam MVP Visakhapatnam, Andhra Pradesh | |
| Medisch Centrum Haaglanden Locatie Westeinde Ziekenhuis The Hague, | |
| Medisch Spectrum Twente Enschede, | |
| Medizinische Hochschule Hannover - Kardiologie und Angiologie Hanover, | |
| Meir MC - Cardiology department Kfar Saba, | |
| Memorial Healthcare Owosso, Michigan | |
| Mercy Gilbert Medical Center Gilbert, Arizona | |
| Mercy Health - St. Vincent Medical Center Toledo, Ohio | |
| Mercy Research Springfield, Missouri | |
| MercyOne NE Iowa Fam Med & Res Waterloo, Iowa | |
| Mersin City Hospital Mersin, | |
| Mersin University Cardiology Mersin, | |
| Methodist Healthcare System of San Antonio San Antonio, Texas | |
| Methodist Physicians Clinic Omaha, Nebraska | |
| MetroHealth Medical Center Cleveland, Ohio | |
| Metropolitan General Hospital Healthcare Facilities Operation And Management Single Member S.A. Athens, | |
| Mhat "Nch" Sofia, | |
| MidMic Medical Cntr - Midland Midland, Michigan | |
| Midwest Cardiovascu Rsrch Foundation Elkhart, Indiana | |
| Midwest Heart and Vascular Specialists Overland Park, Kansas | |
| Midwest Heart and Vascular Specialists Overland Park, Kansas | |
| Miedziowe Centrum Zdrowia s.a. Lubin, | |
| Missouri Cardiovascular Specialist Columbia, Missouri | |
| Mito Saiseikai General Hospital_Cardiology Ibaraki, | |
| Miyazaki Medical Association Hospital Miyazaki, Miyazaki | |
| Miyazaki Medical Association Hospital_Cardiology Miyazaki, Miyazaki | |
| Mobile Heart USA Health Cardiology Clinic Mobile, Alabama | |
| Monument Health Clinical Rsrch Rapid City, South Dakota | |
| Morriston Hospital Swansea, | |
| Moses H. Cone Mem Hosp Greensboro, North Carolina | |
| Mount Sinai Morningside New York, New York | |
| Multi-Profile Hospital For Active Treatment - City Clinic - Sveti Georgi EOOD Montana, | |
| Multicare Health System Tacoma, Washington | |
| Multidisciplinary Hospital For Active Treatment Cardiolife Ltd. Lovech, | |
| Multiprofile Hospital For Active Treatment Dr. Tota Venkova AD Gabrovo, | |
| Multiprofile Hospital For Active Treatment Ivan Skenderov EOOD Gotse Delchev, | |
| Musgrove Park Hospital Taunton, | |
| Myongji Hospital Goyang-si, Gyeonggi-do | |
| NC Heart and Vascular Research Raleigh, North Carolina | |
| NHO Kure Medical Center and Chugoku Cancer Center Kure-shi, Hiroshima, | |
| NUPEC Cardio Belo Horizonte, | |
| NYU Grossman School of Med New York, New York | |
| Nanfang Hospital, Southern Medical University Guangzhou, | |
| Nanfang Hospital, Southern Medical University Guangzhou, | |
| Nanjing Drum Tower Hospital Nanjing, | |
| Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy Warsaw, | |
| National Heart Institute Beverly Hills, California | |
| National Heart Institute Beverly Hills, California | |
| National Hospital Organization Kumamoto Medical Center_Cardiology Kumamoto, | |
| Necmettin Erbakan University Hospital Konya, | |
| Nemocnice AGEL Třinec-Podlesí a.s. Třinec, | |
| Nemocnice Na Homolce Prague, | |
| Nemocnice Pardubickeho kraje a.s. Pardubice, | |
| Nemocnice České Budějovice a.s. České Budějovice, | |
| Nepean Hospital Kingswood, New South Wales | |
| New Brunswick Heart Centre Saint John, New Brunswick | |
| New Cross Hospital Wolverhampton, | |
| Niagara Health System St. Catharines, Ontario | |
| Nil Ratan Sircar Medical College and Hospital Kolkata, West | |
| Nimits Hospital Athens, | |
| Nishinomiya Watanabe Cardiovascular Cerebral Center_Cardiovascular Medicine Hyōgo, | |
| Noordwest Ziekenhuisgroep Alkmaar, | |
| Nordsjællands Hospital Hillerød, | |
| North Kansas City Hospital Kansas City, Missouri | |
| North Mississippi Medical Center Tupelo, Mississippi | |
| Northeast Georgia Medical Ctr Gainesville, Georgia | |
| Northern General Hospital Sheffield, | |
| Northern Health Epping, Victoria | |
| Northern Light Eastern Maine Medical Center Bangor, Maine | |
| Novant Hlth Cardio - Kimel Park Winston-Salem, North Carolina | |
| Nuevo Hospital Civil "Dr. Juan I. Menchaca" Guadalajara, Jalisco | |
| Nuevo Hospital Civil "Dr. Juan I. Menchaca" Guadalajara, Jalisco | |
| OLVG Oost Amsterdam, | |
| OSF HealthCare_Cardiovasc Inst Rockford, Illinois | |
| Odense Universitetshospital, Kardiologisk afd. Odense C, | |
| Ondokuz Mayıs Universitesi Tıp Fakültesi Samsun, | |
| Osaka General Medical Center_Cardiology Osaka, | |
| Osmania General Hospital Hyderabad, Telangana | |
| Ospedale Civile dell'Annunziata Cosenza, | |
| Ospedale Isola Tiberina Gemelli Isola Rome, | |
| Ospedale Maggiore Carlo Alberto Pizzardi Bologna, | |
| Ospedale Misericordia Grosseto Grosseto, | |
| Ospedale Policlinico San Martino Genoa, Liguria | |
| Ospedale Sandro Pertini - UOC Cardiologia Rome, | |
| Ospedale Sant'Andrea - Cardiology La Spezia, | |
| Overton Brooks V.A. Medical Center Shreveport, Louisiana | |
| Overton Brooks V.A. Medical Center Shreveport, Louisiana | |
| PUCCAMP - Hospital e Maternidade Celso Pierro Campinas, São Paulo | |
| Pan-Arcadian General Hospital of Tripoli Evangelistria Tripoli, | |
| Parkway Cardiology Associates, PC Oak Ridge, Tennessee | |
| Peking University First Hospital-Cardiology Beijing, Beijing Municipality | |
| Peking University Third Hospital Beijing, Beijing Municipality | |
| Penn State Hershey Medical Center Hershey, Pennsylvania | |
| Penn State Hlth Holy Spirit Med Ctr Camp Hill, Pennsylvania | |
| PharmaTex Research, LLC Amarillo, Texas | |
| Podhalanski Szpital Specjalistyczny Nowy Targ, | |
| Policlinico Casilino - Cardiologia e UTIC Rome, | |
| Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh Chandigarh, | |
| Prairie Cardiovascular Consultants, Ltd. Springfield, Illinois | |
| Presidio Ospedaliero di Rivoli Rivoli, To | |
| Prince of Wales Hospital_Randwick Randwick, New South Wales | |
| Princess Alexandra Hospital Queensland, Queensland | |
| Princess Alexandra Hospital Queensland, Queensland | |
| Prism Hlth Carolina Card Cons Greenville, South Carolina | |
| ProMedica Toledo, Ohio | |
| Prolato Clinical Research Cntr Houston, Texas | |
| Pusan National University Yangsan Hospital Yangsan, Gyeongsangnam-do | |
| QE II Health Sciences Centre Halifax, Nova Scotia | |
| Queen Alexandra Hospital Portsmouth, | |
| Queen Alexandra Hospital Portsmouth, | |
| Rabin MC -Beilinson - Cardiac intensive unit Petah Tikva, | |
| Radboudumc Nijmegen, Gelderland | |
| Ramaiah Memorial Hospital Bengaluru, Karnataka | |
| Rambam MC - Cardiac Intensive Care Unit Haifa, | |
| Reading Hospital West Reading, Pennsylvania | |
| Regina General Hospital Regina, Saskatchewan | |
| Regions Hospital Saint Paul, Minnesota | |
| Reid Physician Associates Richmond, Indiana | |
| Renmin Hospital of Wuhan University-Cardiology Wuhan, Hubei | |
| Rhode Island Hospital Providence, Rhode Island | |
| Rhythm Heart Institute Vadodara, Gujarat | |
| Rhön-Klinikum AG - Zentralklinik Bad Berka - Kardiologie Bad Berka, | |
| Rigshospitalet Copenhagen, | |
| Rijnstate Ziekenhuis Arnhem, | |
| Robert Packer Hospital Sayre, Pennsylvania | |
| Robert-Bosch-Krankenhaus GmbH Stuttgart Stuttgart, | |
| Royal Adelaide Hospital Cardiovascular Clinical Trials Adelaide, South Australia | |
| Royal Alexandra Hospital Edmonton, Alberta | |
| Royal Bournemouth Hospital Bournemouth, Dorset | |
| Royal Brisbane and Women's Hospital Herston, Queensland | |
| Royal Brompton and Harefield Hospitals Harefield, Middlesex | |
| Royal Cornwall Hospital (Treliske) Truro, Cornwall | |
| Royal Infirmary of Edinburgh - Cardiology Edinburgh, | |
| Royal Perth Hospital Perth, Western Australia | |
| Royal University Hospital Saskatoon, Saskatchewan | |
| Royal Victoria Regional Health Centre Barrie, Ontario | |
| S Denver Cardiology Associates Littleton, Colorado | |
| S.P. Medical College & Associated Group of Hospitals Bikaner, Rajasthan | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCANMED Spółka Akcyjna Kutno, | |
| SCB Medical College and Hospital Cuttack, Odisha | |
| SHATC - Cardiolife OOD Varna, | |
| SHATC - Medica Kor EAD Rousse, | |
| SHATC - Yambol EAD Yambol, | |
| SMC Heart Institute and IVF Research Centre Raipur, Chhattisgarh | |
| SMS Medical College & Attached Hospitals Jaipur, Rajasthan | |
| Sahyadri Super Speciality Hospital Pune, | |
| Saint Elizabeth Medical Center Edgewood, Kentucky | |
| Saint Joseph's Hospital Health Center Liverpool, New York | |
| Saint Paul's Hospital Vancouver, British Columbia | |
| Saint Thomas Hospital Nashville, Tennessee | |
| Saiseikai Yokohamashi Nanbu Hospital_Cardiology Yokohama-shi, Kanagawa, | |
| Saiseikai Yokohamashi Tobu Hospital_Cardiology Kanagawa, | |
| Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II Grodzisk Mazowiecki, | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie Rzeszów, Podkarpackie Voivodeship | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie Krakow, | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Pulawach Puławy, Lublin Voivodeship | |
| Samodzielny Publiczny Zespol Opieki Zdrowotnej w Swidnicy Swidnica, | |
| Samodzielny Publiczny Zespol Opieki Zdrowotnej w Swidnicy Swidnica, | |
| Samodzielny Publiczny Zespół Zakładów Opieki Zdrowotnej w Ostrowi Mazowieckiej Ostrów Mazowiecka, | |
| San Diego Cardiac Center San Diego, California | |
| San Francisco V.A. Medical Center San Francisco, California | |
| Sanatorio Finochietto Buenos Aires, | |
| Sanatorio Finochietto Buenos Aires, | |
| Sanatorio Güemes CABA, City of Buenos Aires | |
| Sanatorio Modelo Quilmes Quilmes, Buenos Aires | |
| Sanatorio Parque Rosario, Santa Fe Province | |
| Sanford Health - Fargo Fargo, North Dakota | |
| Sanford Health - Fargo Fargo, North Dakota | |
| Sanford Research Sioux Falls, South Dakota | |
| Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Sarawak Heart Centre Kota Samarahan, Sarawak | |
| Sardar Vallabhbhai Patel Institute of Medical Sciences and Research Ahmedabad, Gujarat | |
| Sentara Bayside Hospital Norfolk, Virginia | |
| Seoul National University Bundang Hospital Seongnam-si, | |
| Seoul National University Hospital Seoul, | |
| Servicios Integrales Nova de Monterrey San Nicolás de los Garza, | |
| Servicios Integrales Nova de Monterrey San Nicolás de los Garza, | |
| Seth GS Medical College & KEM Hospital Mumbai, Maharashtra | |
| Severance Hospital, Yonsei University Health System Seoul, | |
| Shamir MC - Cardio and Pedi Beer Yaakov, | |
| Sheba MC - Cardiology Clinical Research Unit Tel Litwinsky, | |
| Shengjing Hospital of China Medical University Shenyang, Liaoning | |
| Shengjing Hospital of China Medical University-Cardiology Shenyang, Liaoning | |
| Shiga University of Medical Science Hospital_Cardiology Shiga, | |
| Shri B. D. Mehta Mahavir Heart Institute Surat, Gujarat | |
| Shri Krishna Hrudayalaya & Critical Care Centre Nagpur, Maharashtra | |
| Shri Mahant Indiresh Hospital Dehradun, Uttarakhand | |
| Sichuan Provincial People's Hospital-Cardiology Chengdu, Sichuan | |
| Sir Ganga Ram Hospital New Delhi, National Capital Territory of Delhi | |
| Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou, | |
| Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou, | |
| Sismanogleio General Hospital Marousi, | |
| Sourasky MC - Cardio Vascular Research Center Tel Aviv, | |
| South Oklahoma Heart Research, LLC Oklahoma City, Oklahoma | |
| South Oklahoma Heart Research, LLC Oklahoma City, Oklahoma | |
| Southlake Regional Hlth Centre Newmarket, Ontario | |
| Specialized Hospital For Active Cardiology Treatement Cardiolife OOD Varna, | |
| Specjalistyczny Szpital Im. E. Szczeklika W Tarnowie Tarnów, | |
| Specjalistyczny Szpital Im. E. Szczeklika W Tarnowie Tarnów, | |
| Specjalistyczny Szpital Miejski im. M.Kopernika w Toruniu Torun, | |
| Sri Jayadeva Institute of Cardiovascular Sciences & Research Bengaluru, Karnataka | |
| Sri Ramachandra Medical Centre Chennai, Tamil Nadu | |
| Sri Ramachandra Medical Centre Chennai, Tamil Nadu | |
| Ss. Annunziata Chieti, Abruzzo | |
| St Francis Hospital Lindner Research Center Roslyn, New York | |
| St Francis Hospital Lindner Research Center Roslyn, New York | |
| St. Boniface Hospital Winnipeg, Manitoba | |
| St. Boniface Hospital Winnipeg, Manitoba | |
| St. Luke's Idaho Cardiology Associates Meridian, Idaho | |
| St. Michael's Hospital Toronto, Ontario | |
| St.Jude Clin-NovantHemby Child Charlotte, North Carolina | |
| St.Mary's Hospital_Cardiology Fukuoka, | |
| Sterling Hospitals, Race Course Road Vadodara, Gujarat | |
| Stony Brook University Hospital Stony Brook, New York | |
| Städt. Klinikum Dresden - 2. Medizinische Klinik Dresden, | |
| Sultan Ahmad Shah Medical Centre @IIUM Kuantan, Pahang | |
| Sunnybrook Health Sciences Centre Toronto, Ontario | |
| Sunshine Coast University Hospital Birtinya, Queensland | |
| Sunshine Hospital St Albans, Victoria | |
| Swedish Medical Center_Seattle Seattle, Washington | |
| Szpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o. Warsaw, | |
| Szpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o. Warsaw, | |
| Szpital Miejski Nr 4 w Gliwicach Sp. z o.o., Oddzial Kardiologii Gliwice, Silesian Voivodeship | |
| Szpital Uniwersytecki Nr 2 im. Dr. Jana Biziela Bydgoszcz, | |
| Szpital Wolski im. dr Anny Gostyńskiej Sp. z o.o. Warsaw, | |
| Szpitale Pomorskie Sp. z o.o. Gdynia, Pomeranian Voivodeship | |
| T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan Adana, | |
| TEDA International Cardiovascular Hospital-Cardiovascular Tianjin, Tianjin Municipality | |
| Teda International Cardiovascular Hospital Tianjin, Tianjin Municipality | |
| Teikyo University Hospital_Cardiology Tokyo, | |
| Tennova HC Turkey Creek MC Knoxville, Tennessee | |
| Tergooi, locatie Hilversum Hilversum, | |
| Texas Heart Inst Medical Ctr Houston, Texas | |
| The 1st Affiliated Hospital of WMU-Cardiology Wenzhou, Zhejiang | |
| The Alfred Hospital Melbourne, Victoria | |
| The Catholic University of Korea, Bucheon St. Mary's Hospital Bucheonsi Weonmigu, | |
| The Catholic University of Korea, Seoul St. Mary's Hospital Seoul, | |
| The First Affiliated Hospital of Harbin Medical University Harbin, | |
| The First Affiliated Hospital of Harbin Medical University Harbin, | |
| The First Affiliated Hospital of WMU-Cardiology Wenzhou, Zhejiang | |
| The First Affiliated Hospital of Xi'an Jiaotong University-Cardiovascular Xi'an, Shaanxi | |
| The First Affiliated hospital of Fujian Medical University Fuzhou, Fujian | |
| The Heart House Haddon Heights Haddon Heights, New Jersey | |
| The James Cook University Hospital Middlesbrough, | |
| The Madras Medical Mission Chennai, Tamil Nadu | |
| The New York Hospital Brooklyn, New York | |
| The People's Hospital of Guangxi Zhuang Autonomous Region Nanning, Guangxi | |
| The People's Hospital of Liaoning Province Shenyang, Liaoning | |
| The People's Hospital of Liaoning Province-Cardiology Shenyang, Liaoning | |
| The Prince Charles Hospital Chermside, Queensland | |
| The Sakakibara Heart Institute of Okayama_Department of Cardiovascular Medicine Okayama, | |
| The Second Affiliated Hospital Of Chongqing Medical University Chongqing, Chongqing Municipality | |
| The Second Affiliated Hospital of Nanjing Medical university Nanjing, | |
| The Second Xiangya Hospital of Central South University Changsha, | |
| Tianjin People's Hospital Tianjin, Tianjin Municipality | |
| Toho University Sakura Medical Center_Cardiology Chiba, | |
| Tohoku University Hospital, Cardiovascular Sendai-shi, Miyagi, | |
| Tokai University Hospital_Cardiology Kanagawa, | |
| Tokai University Hospital_Cardiology Kanagawa, | |
| Tokat Gaziosmanpaşa Üniversitesi Tıp Fakültesi Hastanesi Tokat Province, | |
| Tokushima Prefectural Central Hospital_Cardiology Tokushima, | |
| Torbay Hospital Torquay, | |
| Torrance Memorial Medical Center Torrance, California | |
| Townsville University Hospital Douglas, | |
| Trakya University Edirne, | |
| Trinity Health Michigan Heart Ypsilanti, Michigan | |
| Trinity Health Oakland Hospital Pontiac, Michigan | |
| Trinity Medical Group Minot, North Dakota | |
| Trinity Medical WNY, PC Buffalo, New York | |
| Tsuchiura Kyodo General Hospital_Internal Medicine Ibaraki, | |
| Tsukuba Medical Center Hospital_Department of Cardiology Tsukuba-shi, Ibaraki, | |
| Tzaneio General Hospital of Piraeus Piraeus, | |
| U.G.H of Athens "Attikon" Chaidari, Athens, | |
| UCSD Medical Center San Diego, California | |
| UF Hlth Jacksonville Jacksonville, Florida | |
| UHN-Toronto General Hospital Toronto, Ontario | |
| UHN-Toronto General Hospital Toronto, Ontario | |
| UMC Groningen Groningen, | |
| UMC of Southern Nevada Las Vegas, Nevada | |
| UMHAT "Deva Maria" EOOD Burgas, | |
| UMHAT "Sveta Marina" EAD Varna, | |
| UMHAT Pulmed, Department of Cardiology Plovdiv, | |
| UMHAT Sofiamed Sofia, | |
| UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology Plovdiv, | |
| UNC Hospital HVC_Meadowmont Chapel Hill, North Carolina | |
| UT Health University of Texas Houston, Texas | |
| Unidad Medica de Alta Especialidad No. 71 IMSS Torreón, Coahuila | |
| Unidad Medica de Alta Especialidad No. 71 IMSS Torreón, Coahuila | |
| Uniklinik Klinikum Bielefeld - Kardiologie und Internist. Intensivmedizin Bielefeld, | |
| Uniklinik Regensburg - Innere Medizin II Regensburg, | |
| Uniklinik TU Dresden - Herzzentrum Dresden GmbH Dresden, | |
| Uniklinik Tübingen - Innere Med. III Kardiologie und Angiologie Tübingen, | |
| UniklinikHeidelberg - Innere Med. III - Kardiologie, Angiologie, Pneumologie Heidelberg, | |
| Union Hospital Tongji Medical College Huazhong University of Science and Technology-Cardiology Wuhan, Hubei | |
| Univ Gen Hospital Larisa, Cardiology Medicine Clinic Larissa/Thessaly, Greece | |
| Univ of Alberta Hosp Edmonton Edmonton, Alberta | |
| Univ of Mississippi Med Center Jackson, Mississippi | |
| Universiti Teknologi MARA, Sungai Buloh Campus Sungai Buloh, Selangor | |
| University General Hospital of Ioannina,Internal Medicine Ioannina, | |
| University General Hospital of Ioannina,Internal Medicine Ioannina, | |
| University Hospitals of Cleveland Medical Center Elyria, Ohio | |
| University Malaya Medical Centre Kuala Lumpur, | |
| University Medical Center New Orleans New Orleans, Louisiana | |
| University Multidisciplinary Hospital for Active Treatment Sveta Ekaterina EAD Sofia, | |
| University Of Washington_Seattle Seattle, Washington | |
| University of CO - Division of Cardiology Aurora, Colorado | |
| University of Californ LA-UCLA Los Angeles, California | |
| University of California Irvine Irvine, California | |
| University of Cincinnati/UC Health Cincinnati, Ohio | |
| University of Florida Gainesville, Florida | |
| University of Kansas Hospital Kansas City, Kansas | |
| University of Louisville Louisville, Kentucky | |
| University of Ottawa Heart Ins Ottawa, Ontario | |
| University of Rochester Rochester, New York | |
| University of Texas Medical Branch Galveston, Texas | |
| University of Texas Southwestern Medical Center Dallas, Texas | |
| University of Toledo Toledo, Ohio | |
| University of Virginia Charlottesville, Virginia | |
| Universitätsklinikum Düsseldorf - Klinik für Kardiologie, Pneumologie und Angiologie Düsseldorf, | |
| Universitätsklinikum Frankfurt aM - Kardiologie Frankfurt am Main, | |
| Universitätsklinikum Freiburg - Medical Center Freiburg im Breisgau, | |
| Universitätsklinikum Hamburg-Eppendorf - University Medical Center Hamburg-Eppendorf Hamburg, | |
| Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie Leipzig, | |
| Universitätsklinikum Mannheim - 1. Medizinische Klinik Mannheim, | |
| Uniwersytecki Szpital Kliniczny Nr 2 PUM W Szczecinie Szczecin, | |
| Uniwersytecki Szpital Kliniczny W Poznaniu Poznan, | |
| Uniwersytecki Szpital Kliniczny W Poznaniu Poznan, | |
| Uniwersytecki Szpital Kliniczny nr 2 Uniwersytetu Medycznego w Łodzi Lodz, | |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Bialystok, | |
| Uniwersytecki Szpital Kliniczny w Opolu Opole, | |
| Uniwersytecki Szpital Kliniczny w Opolu Opole, | |
| Uniwersyteckie Centrum Kliniczne (UCK) Gdansk, | |
| Uniwersyteckie Centrum Kliniczne WUM Warsaw, | |
| Uniwersyteckie Centrum Kliniczne WUM Warsaw, | |
| VA Greater Los Angeles Hlthcare System Los Angeles, California | |
| VA Medical Center_Minneapolis Minneapolis, Minnesota | |
| VA Medical Center_Salem Salem, Virginia | |
| Valley Clinical Trials Covina, California | |
| Valley Clinical Trials Covina, California | |
| Valley Health Link Winchester, Virginia | |
| Vancouver General Hospital Vancouver, British Columbia | |
| Vanderbilt University Medical Center Nashville, Tennessee | |
| Vanderbilt University Medical Center Nashville, Tennessee | |
| Vardhaman Mahavir Medical College & Safdarjung Hospital New Delhi, National Capital Territory of Delhi | |
| Vijan Hospital & Research Centre Nashik, Maharashtra | |
| Virginia Commonwealth University Health System Richmond, Virginia | |
| Virtua Health Camden, New Jersey | |
| WMU Homer Stryker MD School of Medicine Kalamazoo, Michigan | |
| Wake Forest Uni Hlth Sciences High Point, North Carolina | |
| Washington University School of Medicine_St. Louis St Louis, Missouri | |
| Wayne State University/University Health Center Detroit, Michigan | |
| West China Hospital Sichuan University-Cardiology Chengdu, Sichuan | |
| Westchester Medical Center Valhalla, New York | |
| Westchester Medical Center Valhalla, New York | |
| William Harvey Hospital Ashford, Kent | |
| William Harvey Hospital Ashford, Kent | |
| William Osler Hel Bra Civic Hs Brampton, Ontario | |
| Winter Haven Hospital Winter Haven, Florida | |
| Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu Przemyśl, | |
| Wojewodzki Szpital Specjalistyczny W Bialej Podlaskiej Biała Podlaska, | |
| Wojewodzki Szpital Specjalistyczny We Wroclawiu Wroclaw, | |
| Wojewodzki Szpital Specjalistyczny We Wroclawiu Wroclaw, | |
| Wojewodzki Szpital Zespolony W Elblagu samodzielny publiczny zakład opieki zdrowotnej Elblag, | |
| Wojewodzki Szpital Zespolony W Elblagu samodzielny publiczny zakład opieki zdrowotnej Elblag, | |
| Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego, Lodz, | |
| Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego, Lodz, | |
| Wojewódzki Szpital Specjalistyczny im. NMP w Częstochowie Częstochowa, | |
| Wojewódzki Szpital Zespolony im. dr. Romana Ostrzyckiego w Koninie Konin, | |
| Wolfson MC - The Heart Institute Holon, | |
| Wonju Severance Christian Hospital Gangwon-do, | |
| Wright State University Fairborn, Ohio | |
| Xiangya Hospital Central-South University Changsha, Hunan | |
| Yale Ctr for Clin Invest New Haven, Connecticut | |
| Yokohama City University Hospital Kanagawa, | |
| Yokohama City University Medical Center_Cardiovascular Center Kanagawa, | |
| Yokohama Municipal Citizen's Hospital_Cardiology Kanagawa, | |
| Zespol Zakladow Opieki Zdrowotnej w Ostrowie Wielkopolskim Ostrów Wielkopolski, Greater Poland Voivodeship | |
| Zespół Zakładów Opieki Zdrowotnej w Ostrowie Wielkopolskim Ostrów Wielkopolski, Greater Poland Voivodeship | |
| Zhejiang Hospital, Zhejiang University School of Medicine Hangzhou, | |
| Zhejiang Hospital-Cardiology Hangzhou, Zhejiang | |
| Zhongda Hospital Southeast University Nanjin, | |
| Zhongda Hospital, Southeast University Nanjing, | |
| Zhongshan Hospital, Fudan University-Cardiology Shanghai, Shanghai Municipality | |
| Śródmiejskie Centrum Kliniczne,II Oddział Kardiologii MSB, Klinika Chorób Serca CMKP Warsaw, |
HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants (ESTHI)
Nichol Nunn - nichol.nunn@hsc.utah.edu
NCT04177914
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
• Corrected age \<104 weeks and 0 days, AND
• Child is ≥ 37 weeks post menstrual age, AND
• Child must have symptomatic hydrocephalus, defined as: Ventriculomegaly on MRI (frontal-occipital horn ratio (FOR) \>0.45, which approximates "moderate ventriculomegaly"), and at least one of the following: * Head circumference \>98th percentile for corrected age with either bulging fontanelle or splayed sutures * Upgaze paresis/palsy (sundowning) * CSF leak * Papilledema * Tense pseudomeningocele or tense fluid along a track * Vomiting or irritability, with no other attributable cause * Bradycardias or apneas, with no other attributable cause * Intracranial pressure (ICP) monitoring showing persistent elevation of pressure with or without plateau waves AND
• No prior history of shunt insertion or endoscopic third ventriculostomy (ETV) procedure (previous temporization devices and/or external ventricular drains permissible)
Exclusion Criteria:
• Hydrocephalus due to intraventricular hemorrhage in a child born before 37 weeks gestational age; OR
• Anatomy not suitable for ETV+CPC or anteriorly placed ventriculoperitoneal shunt defined as: * Moderate to severe prepontine adhesions on steady state free precession (SSFP) or T2 weighted fast (turbo) spin echo (FSE/TSE) MRI, which includes the following sequences: FIESTA, FIESTA-C, TrueFISP, CISS, Balanced FFE (bFFE), CUBE, SPACE, VISTA, IsoFSE, and 3D MVOX * Closure of one or both foramina of Monro * Thick floor of third ventricle (≥ 3mm) * Narrow third ventricle (\<5mm) * Presence of scalp, bone, or ventricular lesions that make placement of an anterior shunt impracticable; OR
• Underlying condition with a high chance of mortality within 12 months; OR
• Hydrocephalus with loculated CSF compartments; OR
• Peritoneal cavity not suitable for distal shunt placement; OR
• Active CSF infection; OR
• Hydranencephaly; OR
• Child requires an intraventricular procedure (e.g. endoscopic biopsy) in addition to the initial first-time permanent procedure for the treatment of hydrocephalus.
PROCEDURE: Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization (ETV+CPC), DEVICE: Ventriculoperitoneal Shunt
Hydrocephalus
Hydrocephalus, Infants, Ventriculoperitoneal Shunt, ETV+CPC, endoscopic third ventriculostomy, choroid plexus cauterization
I'm interested
Share via email
Show 21 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Alberta Children's Hospital Calgary, Alberta | Ruksana Rashid, MBBS MPH MSc - (rsrashid@ucalgary.ca) |
| Arnold Palmer Hospital for Children Orlando, Florida | Richard Guerrero - (richard.guerrero@orlandohealth.com) |
| British Columbia Children's Hospital Vancouver, British Columbia | Annika Weirs - (annika.weir@cw.bc.ca) |
| Children's Hospital Colorado Aurora, Colorado | Susan Staulcup, 80045 - (SUSAN.STAULCUP@UCDENVER.EDU) |
| Children's Hospital of Los Angeles Los Angeles, California | Helen Berroya - (hberroya@chla.usc.edu) |
| Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania | Kimberly Diamond, BS, BA - (diamondkl@upmc.edu) |
| Children's Of Alabama Birmingham, Alabama | Anastasia Smith, MPH - (Anastasia.Smith@childrensal.org) |
| Johns Hopkins Children's Center Baltimore, Maryland | Sydney White - (swhit128@jh.edu) |
| Monroe Carell Jr. Children's Hospital at Vanderbilt Nashville, Tennessee | Julia Loes - (julia.loes@vumc.org) Stephen Gannon - (stephen.r.gannon@vumc.org) |
| Nationwide Children's Hospital Columbus, Ohio | Jared Haught - (Jared.Haught@nationwidechildrens.org) |
| Phoenix Children's Hospital Phoenix, Arizona | Bethany Norton - (bnorton1@phoenixchildrens.com) |
| Primary Children's Hospital Salt Lake City, Utah | Alli Ludwick - (allison.ludwick@hsc.utah.edu) |
| Seattle Children's Hospital Seattle, Washington | Jessica Becerra - (Jessica.Becerra@seattlechildrens.org) |
| St. Louis Children's Hospital St Louis, Missouri | Diego Morales, MS - (moralesd@wudosis.wustl.edu) Mary Goldschmidt - (goldschmidt@wustl.edu) |
| Texas Children's Hospital Houston, Texas | Edgardo Santisbon - (exsantis@texaschildrens.org) |
| The Hospital for Sick Children Toronto, Ontario | Homa Ashrafpour - (homa.ashrafpour@sickkids.ca) |
| The Pennsylvania State University University Park, Pennsylvania | |
| Trustees of Indiana University Indianapolis, Indiana | Mariah Shirrell - (mkillin@iu.edu) |
| Virginia Commonwealth University Richmond, Virginia | |
| Wolfson Children's Hospital Jacksonville, Florida | Asmaa Hatem - (Asmaa.Hatem@jax.ufl.edu) |
| Yale University New Haven, Connecticut |
ASSESS ALL ALS Study
ALL ALS Patient Navigator - info@all-als.org
NCT06578195
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria for ALS participants:
• Age 18 years or older
• Capable of providing informed consent
• Willing to follow study procedures
• Diagnosis of ALS by a physician
• Access to a smartphone, computer or tablet, and internet (need not be in the home - access to a public library or other available computer with internet connection is sufficient) Inclusion Criteria for control participants:
• Age 18 years or older
• Capable of providing informed consent
• Willing to follow study procedures
• No diagnosis of ALS , Progressive Muscular Atrophy (PMA) or Primary Lateral Sclerosis (PLS)
• No history of familial ALS/Frontotemporal Dementia (FTD) in a close family member\*\* unless the participant has previously tested negative for the known causative ALS genes. Participants with a family history of singleton ALS are permitted to enroll. * \*\* Defined by the presence of a known ALS causative gene such as C9orf72 in a family member or a family history suggestive of an inherited ALS/FTD syndrome defined by two family members with a history of ALS and/or FTD.
• Access to a smartphone, computer or tablet, and internet (need not be in the home - access to a public library or other available computer with internet connection is sufficient) Exclusion Criteria for all participants:
• Significant cognitive impairment, clinical dementia, or unstable psychiatric illness, including psychosis, active suicidal ideation, suicide attempt, or untreated major depression \<= 90 days of screening, that would interfere with the study procedure, according to Investigator's judgement.
• Clinically significant unstable medical condition (other than ALS) (e.g., cardiovascular instability, systemic infection, untreated thyroid dysfunction, malignant and potentially progressive cancer) that would render the participant unlikely to be able to complete 12 months of follow-up, according to Investigator's judgment. Exclusion Criteria for participants undergoing optional Lumbar Puncture
• Medically unable to undergo lumbar puncture (LP) as determined by the site investigator (i.e., bleeding disorder, a skin infection at or near the LP site, known or suspected intracranial or intraspinal tumor or other cause of increased intracranial pressure).
• Allergy to Lidocaine or other local anesthetic agents.
• Use of anticoagulant medication or antiplatelet medications (aside from aspirin 81 mg) that cannot be safely withheld prior to lumbar puncture.
• Blood dyscrasia, abnormal bleeding diathesis, or the use of dialysis for renal failure.
• Current pregnancy based on participant self-report
• Clinical judgement of the site investigator that the participant would be unable to undergo multiple lumbar punctures.
• Age 18 years or older
• Capable of providing informed consent
• Willing to follow study procedures
• Diagnosis of ALS by a physician
• Access to a smartphone, computer or tablet, and internet (need not be in the home - access to a public library or other available computer with internet connection is sufficient) Inclusion Criteria for control participants:
• Age 18 years or older
• Capable of providing informed consent
• Willing to follow study procedures
• No diagnosis of ALS , Progressive Muscular Atrophy (PMA) or Primary Lateral Sclerosis (PLS)
• No history of familial ALS/Frontotemporal Dementia (FTD) in a close family member\*\* unless the participant has previously tested negative for the known causative ALS genes. Participants with a family history of singleton ALS are permitted to enroll. * \*\* Defined by the presence of a known ALS causative gene such as C9orf72 in a family member or a family history suggestive of an inherited ALS/FTD syndrome defined by two family members with a history of ALS and/or FTD.
• Access to a smartphone, computer or tablet, and internet (need not be in the home - access to a public library or other available computer with internet connection is sufficient) Exclusion Criteria for all participants:
• Significant cognitive impairment, clinical dementia, or unstable psychiatric illness, including psychosis, active suicidal ideation, suicide attempt, or untreated major depression \<= 90 days of screening, that would interfere with the study procedure, according to Investigator's judgement.
• Clinically significant unstable medical condition (other than ALS) (e.g., cardiovascular instability, systemic infection, untreated thyroid dysfunction, malignant and potentially progressive cancer) that would render the participant unlikely to be able to complete 12 months of follow-up, according to Investigator's judgment. Exclusion Criteria for participants undergoing optional Lumbar Puncture
• Medically unable to undergo lumbar puncture (LP) as determined by the site investigator (i.e., bleeding disorder, a skin infection at or near the LP site, known or suspected intracranial or intraspinal tumor or other cause of increased intracranial pressure).
• Allergy to Lidocaine or other local anesthetic agents.
• Use of anticoagulant medication or antiplatelet medications (aside from aspirin 81 mg) that cannot be safely withheld prior to lumbar puncture.
• Blood dyscrasia, abnormal bleeding diathesis, or the use of dialysis for renal failure.
• Current pregnancy based on participant self-report
• Clinical judgement of the site investigator that the participant would be unable to undergo multiple lumbar punctures.
Amyotrophic Lateral Sclerosis
ALS, Amyotrophic Lateral Sclerosis, biomarker, observational
I'm interested
Share via email
Show 32 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Barrow Neurological Institute Phoenix, Arizona | Christopher Shiver - (fulton.research@dignityhealth.org) |
| CHALS-CCT, University of Puerto Rico, Medical Sciences Campus San Juan, Puerto Rico | Frances M Aponte - (frances.aponte2@upr.edu) |
| Columbia University New York, New York | Ben Hoover - (alsresearch@cumc.columbia.edu) |
| Dartmouth Hitchcock Medical Center Lebanon, New Hampshire | Gina Kersey - (neuroresearch@hitchcock.org) |
| Duke University Durham, North Carolina | Duke Research Team - (alsresearch@dm.duke.edu) |
| Georgetown University Washington D.C., District of Columbia | Cassandra Holmes - (cassie.holmes@georgetown.edu) |
| Henry Ford Health Detroit, Michigan | Maria Stotland - (mstotla1@hfhs.org) |
| Hospital for Special Care New Britain, Connecticut | Sabine Lebel-Hardenac - (shardenack@hfsc.org) |
| Indiana University Indianapolis, Indiana | Lisa Grinstead - (lgrinste@iu.edu) Patti Hogan - (hoganpr@iu.edu) |
| John Hopkins University Baltimore, Maryland | Delayne Willie - (dwillie2@jh.edu) |
| Massachusetts General Brigham Boston, Massachusetts | Miranda Duncan - (mghassessallals@mgb.org) |
| Mayo Clinic Jacksonville, Florida | Jany Dagher - (dagher.jany@mayo.edu) Jeffery Gainer - (gainer.jeffery@mayo.edu) |
| Nih/Ninds Bethesda, Maryland | Katelyn Porter - (katelyn.porter@nih.gov) |
| Northwestern University Chicago, Illinois | Aeryn Hopwood - (aeryn.hopwood@northwestern.edu) |
| Ohio State University Columbus, Ohio | Alexander Michael - (alsresearch@osumc.edu) |
| Penn State Health Hershey, Pennsylvania | Michele Hare - (nervemuscle@pennstatehealth.psu.edu) |
| Providence ALS Center Portland, Oregon | Kimberly Perry - (kimberly.perry2@providence.org) |
| Saint Alphonsus Regional Medical Center Boise, Idaho | Helena Snider - (neuro.research@saintalphonsus.org) |
| Temple University Philadelphia, Pennsylvania | John Furey - (tuf40109@temple.edu) |
| Texas Neurology Dallas, Texas | Haley Rucker - (hrucker@texasneurology.com) Reham Azab - (razab@texasneurology.com) |
| University of Alabama Birmingham Birmingham, Alabama | Melanie Benge - (melaniebenge@uabmc.edu) |
| University of California San Diego La Jolla, California | Gil Gutierrez - (grg005@health.ucsd.edu) |
| University of California, Irvine Irvine, California | Rosa Gonzalez - (rosaig1@hs.uci.edu) |
| University of California, San Francisco San Francisco, California | Hannah George - (hannah.george@ucsf.edu) |
| University of Colorado Anschutz Medical Campus Aurora, Colorado | Alexis Shepardson - (neuroresearch@cuanschutz.edu) |
| University of Michigan Ann Arbor, Michigan | Caroline Piecuch - (carolinp@med.umich.edu) |
| University of Minnesota Minneapolis, Minnesota | Julia Munoz - (munoz156@umn.edu) |
| University of Nebraska Medical Center Omaha, Nebraska | Nathan McKain - (nmckain@unmc.edu) |
| University of Utah Salt Lake City, Utah | Scott Redlin - (scott.redlin@utah.edu) |
| University of Washington Seattle, Washington | Lila Brisk - (lbrisk@uw.edu) |
| Virginia Commonwealth University Richmond, Virginia | Brianne Schibley-Laird - (brianna.schibleylaird@vcuhealth.org) |
| Washington University St Louis, Missouri | Jesse Markway - (als@wustl.edu) |
A Phase 2 Study of ACR-368 in Endometrial Adenocarcinoma
Mansoor Raza Mirza, MD - ACR-368-201ClinicalTrial@acrivon.com
NCT05548296
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
General
• Participant must be able to give signed, written informed consent.
• Participant must have histologically documented, high-grade endometrial cancer.
• Treatment History Requirements:
• Subject must have received prior platinum-based chemotherapy
• Subject must have received prior anti-PD-(L)1 therapy
• Participant must have histologically confirmed metastatic cancer that has progressed during or after at least 1 prior therapeutic regimen.
• Participant must have at least 1 measurable lesion per RECIST v1.1 criteria (by local Investigator) in a baseline tumor imaging that has been obtained within 28 days of the treatment start. Participant must have radiographic evidence of disease progression based on RECIST v1.1 criteria following the most recent line of treatment.
• Arm 1 and 2 only: Participant must be willing to provide tissue from a newly obtained tumor biopsy from an accessible tumor lesion not previously irradiated after written informed consent. Newly obtained is defined as a specimen taken after written informed consent is obtained, during the 28-day Screening period.
• Participant must be willing to provide an archival tumor tissue block or at least 20 unstained slides, if available.
• Participant must have stabilized or recovered (Grade 1 or baseline) from all prior therapy related toxicities, except as follows:
• Alopecia is accepted.
• Endocrine events from prior immunotherapy stabilized at ≤ Grade 2 due to need for replacement therapy are accepted (including hypothyroidism, diabetes mellitus, or adrenal insufficiency).
• Neuropathy events from prior cytotoxic therapies stabilized at ≤ Grade 2 are accepted.
• Participant must have an Eastern Cooperative Oncology Group Performance Status 0 or 1.
• Participant must have an estimated life expectancy of longer than 3 months.
• Participant must have adequate organ function at Screening, defined as:
• Absolute neutrophil count \> 1500 cells/µL without growth factor support within 1 week prior to obtaining the hematology values at Screening.
• Hemoglobin ≥ 9.0 g/dL.
• Platelets ≥ 150,000 cells/µL without transfusion within 1 week prior to obtaining the hematology values at Screening.
• Calculated creatinine clearance (CrCl) ≥ 50 mL/min as calculated by the Cockcroft-Gault formula.
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 × upper limit of normal (ULN); ≤ 5 × ULN if liver metastases are present.
• Total bilirubin ≤ 1.5 × ULN not associated with Gilbert's syndrome. If associated with Gilbert's syndrome ≤ 3 x ULN is acceptable.
• Serum albumin ≥ 3 g/dL.
• Participant must have adequate coagulation profile as defined below if not on anticoagulation. If subject is receiving anticoagulation therapy, then subject must be on a stable dose of anticoagulation for ≥ 1 month:
• Prothrombin time within 1.5 x ULN.
• Activated partial thromboplastin time within 1.5 x ULN.
Exclusion Criteria:
General
• Participant with known symptomatic brain metastases requiring \> 10 mg/day of prednisolone (or its equivalent). Participants with previously diagnosed brain metastases are eligible if they have completed their treatment, have recovered from the acute effects of radiation therapy or surgery prior to the start of ACR-368 treatment, fulfill the steroid requirement for these metastases, and are neurologically stable based on central nervous system imaging ≥ 4 weeks after treatment.
• Participant has mesenchymal tumors of the uterus.
• Participant has a history of clinically meaningful ascites, defined as history of paracentesis or thoracentesis with therapeutic intent, within 4 weeks of Screening. Subjects with planned therapeutic paracentesis or thoracentesis between Screening and Cycle 1 Day 1 dosing are excluded.
• Participant had systemic therapy or radiation therapy within 3 weeks prior to the first dose of study drug.
• Participants has known human immunodeficiency virus (HIV), hepatitis B, or hepatitis C infection that is considered uncontrolled based on the criteria included in Appendix 2.
• Participant has a history of clinically meaningful coagulopathy, bleeding diathesis.
• Participant has cardiovascular disease, defined as:
• Uncontrolled hypertension defined as blood pressure \> 160/90 mmHg at Screening confirmed by repeat (medication permitted).
• History of torsades de pointes, significant Screening electrocardiogram (ECG) abnormalities, including ventricular rhythm disturbances, unstable cardiac arrhythmia requiring medication, pathologic symptomatic bradycardia, left bundle branch block, second degree atrioventricular (AV) block type II, third degree AV block, Grade ≥ 2 bradycardia, uncorrected hypokalemia not amenable to correction, congenital long QT syndrome, prolonged QT interval due to medications, corrected QT based on Fridericia's formula (QTcF) \> 450 msec (for men) or \> 470 msec (for women).
• Symptomatic heart failure (per New York Heart Association guidelines; (Caraballo, 2019), unstable angina, myocardial infarction, severe cardiovascular disease (ejection fraction \< 20%, transient ischemic attack, or cerebrovascular accident within 6 months of Day 1).
• Participant has a history of major surgery within 4 weeks of Screening.
• Participant has experienced bowel obstruction related to the current cancer within the last 6 months or signs or symptoms of intestinal obstruction, which include nausea, vomiting, or objective radiologic finding of bowel obstruction in the last 4 weeks before the start of the treatment.
• Participant has taken a prior cell cycle CHK1 inhibitor, including ACR-368
DRUG: ACR-368, DRUG: Gemcitabine, DIAGNOSTIC_TEST: OncoSignature
Endometrial Adenocarcinoma
Endometrial Cancer, Endometrial Neoplasm, Ultralow dose gemcitabine, ACR-368
I'm interested
Share via email
Show 69 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Alaska Women's Cancer Center Anchorage, Alaska | |
| American Oncology Partners of Maryland Pa Bethesda, Maryland | |
| Arizona Oncology Associate, PC- HOPE Tucson, Arizona | |
| Ascension St. Vicent Hospital, Inc. Indianapolis, Indiana | |
| Carle Cancer Center Urbana, Illinois | |
| Cedars Sinai Medical Center Los Angeles, California | |
| City of Hope National Medical Center Duarte, California | |
| Cleveland Clinic Foundation Cleveland, Ohio | |
| Dana Farber Cancer Institute Boston, Massachusetts | |
| Emory University Atlanta, Georgia | |
| Firsthealth of The Carolinas Pinehurst, North Carolina | |
| Florida Gynecologic Oncology/Regional Cancer Center Fort Myers, Florida | |
| Fox Chase Cancer Center Philadelphia, Pennsylvania | |
| Fred Hutchinson Cancer Center Seattle, Washington | |
| Froedtert and Medical College of Wisconsin Milwaukee, Wisconsin | |
| Gabrail Cancer Center Canton, Ohio | |
| HCA Midwest Kansas City, Missouri | |
| Hoag Cancer Center Irvine, California | |
| Holy Cross Hospital Fort Lauderdale, Florida | |
| HonorHealth Scottsdale, Arizona | |
| Huntsman Cancer Institute, University of Utah Salt Lake City, Utah | |
| John Theurer Cancer Center at Hackensack University Medical Center Hackensack, New Jersey | |
| Karmanos Cancer Institute Detroit, Michigan | |
| LSU Health Sciences New Orleans, Louisiana | |
| Laura & Isaac Perlmutter Cancer Center New York, New York | |
| Memorial Sloan-Kettering Cancer Center New York, New York | |
| Miami Valley Hospital South Centerville, Ohio | |
| Mount Sinai Comprehensive Cancer Center Miami Beach, Florida | |
| Mount Sinai Health System New York, New York | |
| National Institutes of Health, Clinical Center Bethesda, Maryland | |
| New York Presbyterian Hospital-Columbia University Medical Center New York, New York | |
| Northeast Georgia Medical Center Gainesville, Georgia | |
| Northwest Cancer Specialists, P.C. Vancouver, Washington | |
| Northwestern Medicine Chicago, Illinois | |
| Ohio State University Columbus, Ohio | |
| Oncology Associates of Oregon Eugene, Oregon | |
| Oregon Health & Sciences University Portland, Oregon | |
| Providence Sacred Heart Medical Center and Children's Hospital Spokane, Washington | |
| Rutgers Cancer Institute of Nj New Brunswick, New Jersey | |
| Sanford Health Sioux Falls, South Dakota | |
| Stanford Cancer Center Palo Alto, California | |
| Stephenson Cancer Center at OU Health Oklahoma City, Oklahoma | Ashley Willy - (phase1-referrals@ouhsc.edu) |
| Summit Cancer Center Spokane, Washington | |
| Swedish Cancer Center Seattle, Washington | |
| Texas Oncology Dallas, Texas | |
| Texas Oncology-Dallas Presbyterian Hospital Dallas, Texas | |
| Trials365, LLC Shreveport, Louisiana | |
| UC Irvine Health Orange, California | |
| UC San Diego Moores Cancer Center La Jolla, California | |
| USC/Norris Comprehensive Cancer Center Los Angeles, California | |
| University of Arkansas for Medical Sciences Little Rock, Arkansas | |
| University of California Los Angeles (UCLA) Los Angeles, California | |
| University of California, Davis Comprehensive Cancer Center Sacramento, California | |
| University of Chicago Medicine Chicago, Illinois | |
| University of Cincinnati Cancer Center Cincinnati, Ohio | |
| University of Colorado Aurora, Colorado | |
| University of Illinois Cancer Center Chicago, Illinois | |
| University of Iowa Iowa City, Iowa | |
| University of Massachusetts Chan Medical School Worcester, Massachusetts | |
| University of North Carolina at Chapel Hill Chapel Hill, North Carolina | |
| University of Rochester Medical Center Rochester, New York | |
| University of South Alabama Mitchell Cancer Institute Mobile, Alabama | |
| University of Texas Southwestern Medical Center Dallas, Texas | |
| University of Texas, MD Anderson Cancer Center Houston, Texas | |
| University of Virginia Health System Charlottesville, Virginia | |
| Virginia Commonwealth University Richmond, Virginia | |
| West Penn Hospital Pittsburgh, Pennsylvania | |
| Women & Infants Hospital Providence, Rhode Island | - (oncologyresearch@wihri.org) |
| Yale Cancer Center New Haven, Connecticut |
Double-blind, Randomized, Placebo-controlled Study Evaluating Efficacy and Safety of IgPro20 in Post-COVID-19 POTS
Trial Registration Coordinator - clinicaltrials@cslbehring.com
NCT06524739
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
• Provide written informed consent and be willing and, in the opinion of the investigator, able to adhere to all protocol requirements.
• Males and females aged ≥ 18 at the time of providing written informed consent.
• Diagnosis of post-COVID POTS, defined by both a preceding COVID-19 infection based on confirmed historical documentation and onset of POTS symptoms developing within 4 months after COVID-19 infection as defined per consensus criteria.
• COMPASS-31 score of at least 40 at the Screening visit.
• Positive confirmatory standardized standing test (ie, HR increase of ≥ 30 bpm \[≥ 40 bpm for participants aged 18 to 19 years\] within 10 minutes in the absence of orthostatic hypotension) at the Screening visit.
Exclusion Criteria:
• Treatment with Immunoglobulin G (IgG) or plasmapheresis within 12 weeks before Screening
• Symptoms and / or diagnosis of or receiving treatment for POTS before COVID-19 infection
• Prior diagnosis of or receiving current treatment at Screening for the following conditions (unless onset was related to the inciting POTS-associated COVID-19 infection): certain neurologic, autoimmune, endocrine, cardiac, or other disorders, and pre-existing psychiatric disorders
• Presence of active infections, including human immunodeficiency virus infection, hepatitis B, hepatitis C, active SARS-CoV-2 infection, or any uncontrolled systemic infection
BIOLOGICAL: IgPro20, BIOLOGICAL: Placebo
Post-COVID Postural Orthostatic Tachycardia Syndrome
POTS
I'm interested
Share via email
Show 38 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Arkansas Cardiology Clinic - Little Rock Little Rock, Arkansas | |
| Bateman Horne Center Salt Lake City, Utah | |
| Bernstein Clinical Research Center Cincinnati, Ohio | |
| Center for Complex Neurology, EDS & POTS Phoenix, Arizona | |
| Ciussse-Chus Sherbrooke, | |
| Duke University Medical Center Durham, North Carolina | |
| Dysautonomia Clinic Buffalo, New York | |
| Hightower Clinical Oklahoma City, Oklahoma | |
| Hope Research Network Miami, Florida | |
| Johns Hopkins Bayview Medical Center PMR Baltimore, Maryland | |
| LSU Health Sciences Center New Orleans, Louisiana | |
| Libin Cardiovascular Institute University of Calgary Calgary, | |
| Mass General Brigham (Massachusetts General Hospital) Belmont, Massachusetts | |
| Mayo Clinic Arizona Phoenix, Arizona | |
| McGill University Health Centre Montreal, Quebec | |
| Metrodora Institute West Valley City, Utah | |
| NYU Langone Health South Shore Neurologic Associates Patchogue, New York | |
| National Jewish Health Denver, Colorado | |
| Penn Presbyterian Medical Center Philadelphia, Pennsylvania | |
| Profound Research LLC at Millennium Affiliated Physicians Farmington Hills, Michigan | |
| Prolato Clinical Research Center Houston, Texas | |
| Sunbeam Clinical Research McKinney, Texas | |
| UC San Diego Health San Diego, California | |
| UT Austin Dell Medical School Austin, Texas | |
| University Hospital Cleveland Medical Center Cleveland, Ohio | |
| University Of Texas Health Science Center San Antonio, Texas | |
| University of Alabama Hospital at Birmingham Birmingham, Alabama | |
| University of Alberta Hospital Edmonton, Alberta | |
| University of California Irvine Irvine, California | |
| University of Texas Southwestern Medical Center Dallas, Texas | |
| VCU Health Richmond, Virginia | |
| Vanderbilt University Medical Center Nashville, Tennessee | |
| Velocity Clinical Research - Hampton Hampton, Virginia | |
| Velocity Clinical Research - Lincoln Lincoln, Nebraska | |
| Velocity Clinical Research - Union Union, South Carolina | |
| Velocity Clinical Research, Metairie New Orleans, Louisiana | |
| Velocity Clinical Research, Savannah Savannah, Georgia | |
| Well Pharma Medical Research, Corp Miami, Florida |
DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers
Boehringer Ingelheim - clintriage.rdg@boehringer-ingelheim.com
NCT05882058
Show full eligibility criteria
Hide eligibility criteria
Inclusion criteria:
• Male or female participants ≥18 years old and at least at the legal age of consent in countries where it is greater than 18 years at the time of signature of the informed consent form (ICF).
• Signed and dated written informed consent in accordance with International Council for Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial.
• Part 1: Histologically or cytologically confirmed, cancer of the following histologies: * Small cell lung cancer (SCLC) * Extra-pulmonary neuroendocrine carcinoma (epNEC) (except Merkel cell carcinoma (MCC), Medullary thyroid cancer (MTC) and Neuroendocrine prostate cancer (NEPC)) * Large cell neuroendocrine carcinoma (LCNEC) of the lung Patients with tumours with mixed histologies for any above type are eligible only if the neuroendocrine carcinoma/small tumour cells component is predominant and represents at least 50% of the overall tumour tissue. Patients must have progressed or recurred after standard of care therapy * SCLC: after at least two prior lines of therapy, including at least one platinum-based regimen; in countries where standard of care in first line therapy includes PD-L1 inhibitor treatment patients should have received the combination of platinum-based regimen plus PD-L1 inhibitor unless they have been unable to receive checkpoint inhibitor treatment. * Therapy includes PD-L1 inhibitor treatment; patients should have received the combination of platinum-based regimen plus PD-L1 inhibitor unless they have been unable to receive checkpoint inhibitor treatment. * epNEC/LCNEC: after at least one platinum-based regimen. Part 2: Histologically or cytologically confirmed epNEC (except MCC, MTC and NEPC) with centrally assessed DLL3 high expression status. Patients must have progressed or recurred after at least one platinum-based regimen.
• Eastern Cooperative Oncology Group (ECOG) score of 0 or 1.
• Measurable lesions as defined per Response Evaluation Criteria In Solid Tumours (RECIST) v 1.1 within 21 days prior to the first dose of BI 764532.
• Part 1: Availability of archival tumour tissue sample Part 2: Availability of archival formalin-fixed paraffin-embedded (FFPE) tumour tissue sample. Following specimens are not allowed: Fine Needle Aspiration (FNA), Cytology samples, decalcified bone samples.
• Adequate organ function as defined in the protocol.
• All toxicities related to previous anti-cancer therapies have resolved = Common Terminology Criteria for Adverse Events (CTCAE) Grade 1 prior to trial treatment administration (except for alopecia, peripheral neuropathy, fatigue and endocrinopathies controlled by replacement therapy which must be = CTCAE Grade 2 and amenorrhea/menstrual disorders which can be any grade).
• Women of childbearing potential (WOCBP) and men able to father a child must be ready and able to use acceptable methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria and instructions on the duration of their use is provided in the participant information Exclusion criteria:
• Untreated or symptomatic brain metastases. (Part 2: with mandatory assessment by brain MRI within 21 days before first trial drug administration.) Participants with treated, stable brain metastases are eligible provided they meet the following criteria: * Radiotherapy or surgery for brain metastases was completed at least 2 weeks prior to the first administration of BI 764532. * Patient is off steroids for at least 7 days (physiologic doses of steroids are permitted), and the patient is off anti-epileptic drugs for at least 7 days or on stable doses of anti-epileptic drugs for malignant central nervous system (CNS) disease.
• Presence of leptomeningeal disease or, part 2: epidural disease including spinal cord compression.
• Part 1: Active/previous history of interstitial lung disease or non-infectious pneumonitis (any grade). Part 2: Active/previous history of interstitial lung disease, pulmonary fibrosis, organizing pneumonia or non-infectious pneumonitis (any grade). Patients with a history of therapy-related pneumonitis that is considered clinically resolved are eligible.
• Participants who experienced severe, life-threatening immune-mediated adverse events or infusion-related reactions including those that lead to permanent discontinuation while on treatment with immuno-oncology agents.
• Prior anti-cancer therapy: * Patients who have been treated with any other anti-cancer drug within 4 weeks or within 5 half-life periods (whichever is shorter) prior to first administration of BI 764532. * Patients who have been treated with extensive field radiotherapy including whole brain irradiation within 2 weeks prior to first administration of BI 764532.
• Previous treatment with Delta-like ligand 3 (DLL3)-targeting T cell engagers or cell therapies.
• Diagnosis of immunodeficiency or systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of BI 764532. Physiological replacement of steroids is allowed.
• Unresolved toxicity from prior anti-tumour therapy, defined as per protocol. Further exclusion criteria apply.
• Male or female participants ≥18 years old and at least at the legal age of consent in countries where it is greater than 18 years at the time of signature of the informed consent form (ICF).
• Signed and dated written informed consent in accordance with International Council for Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial.
• Part 1: Histologically or cytologically confirmed, cancer of the following histologies: * Small cell lung cancer (SCLC) * Extra-pulmonary neuroendocrine carcinoma (epNEC) (except Merkel cell carcinoma (MCC), Medullary thyroid cancer (MTC) and Neuroendocrine prostate cancer (NEPC)) * Large cell neuroendocrine carcinoma (LCNEC) of the lung Patients with tumours with mixed histologies for any above type are eligible only if the neuroendocrine carcinoma/small tumour cells component is predominant and represents at least 50% of the overall tumour tissue. Patients must have progressed or recurred after standard of care therapy * SCLC: after at least two prior lines of therapy, including at least one platinum-based regimen; in countries where standard of care in first line therapy includes PD-L1 inhibitor treatment patients should have received the combination of platinum-based regimen plus PD-L1 inhibitor unless they have been unable to receive checkpoint inhibitor treatment. * Therapy includes PD-L1 inhibitor treatment; patients should have received the combination of platinum-based regimen plus PD-L1 inhibitor unless they have been unable to receive checkpoint inhibitor treatment. * epNEC/LCNEC: after at least one platinum-based regimen. Part 2: Histologically or cytologically confirmed epNEC (except MCC, MTC and NEPC) with centrally assessed DLL3 high expression status. Patients must have progressed or recurred after at least one platinum-based regimen.
• Eastern Cooperative Oncology Group (ECOG) score of 0 or 1.
• Measurable lesions as defined per Response Evaluation Criteria In Solid Tumours (RECIST) v 1.1 within 21 days prior to the first dose of BI 764532.
• Part 1: Availability of archival tumour tissue sample Part 2: Availability of archival formalin-fixed paraffin-embedded (FFPE) tumour tissue sample. Following specimens are not allowed: Fine Needle Aspiration (FNA), Cytology samples, decalcified bone samples.
• Adequate organ function as defined in the protocol.
• All toxicities related to previous anti-cancer therapies have resolved = Common Terminology Criteria for Adverse Events (CTCAE) Grade 1 prior to trial treatment administration (except for alopecia, peripheral neuropathy, fatigue and endocrinopathies controlled by replacement therapy which must be = CTCAE Grade 2 and amenorrhea/menstrual disorders which can be any grade).
• Women of childbearing potential (WOCBP) and men able to father a child must be ready and able to use acceptable methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria and instructions on the duration of their use is provided in the participant information Exclusion criteria:
• Untreated or symptomatic brain metastases. (Part 2: with mandatory assessment by brain MRI within 21 days before first trial drug administration.) Participants with treated, stable brain metastases are eligible provided they meet the following criteria: * Radiotherapy or surgery for brain metastases was completed at least 2 weeks prior to the first administration of BI 764532. * Patient is off steroids for at least 7 days (physiologic doses of steroids are permitted), and the patient is off anti-epileptic drugs for at least 7 days or on stable doses of anti-epileptic drugs for malignant central nervous system (CNS) disease.
• Presence of leptomeningeal disease or, part 2: epidural disease including spinal cord compression.
• Part 1: Active/previous history of interstitial lung disease or non-infectious pneumonitis (any grade). Part 2: Active/previous history of interstitial lung disease, pulmonary fibrosis, organizing pneumonia or non-infectious pneumonitis (any grade). Patients with a history of therapy-related pneumonitis that is considered clinically resolved are eligible.
• Participants who experienced severe, life-threatening immune-mediated adverse events or infusion-related reactions including those that lead to permanent discontinuation while on treatment with immuno-oncology agents.
• Prior anti-cancer therapy: * Patients who have been treated with any other anti-cancer drug within 4 weeks or within 5 half-life periods (whichever is shorter) prior to first administration of BI 764532. * Patients who have been treated with extensive field radiotherapy including whole brain irradiation within 2 weeks prior to first administration of BI 764532.
• Previous treatment with Delta-like ligand 3 (DLL3)-targeting T cell engagers or cell therapies.
• Diagnosis of immunodeficiency or systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of BI 764532. Physiological replacement of steroids is allowed.
• Unresolved toxicity from prior anti-tumour therapy, defined as per protocol. Further exclusion criteria apply.
DRUG: BI 764532, dose 1, DRUG: BI 764532, dose 2
Small Cell Lung Carcinoma, Neuroendocrine Neoplasms, Extra-pulmonary Neuroendocrine Carcinoma
I'm interested
Share via email
Show 59 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| 960 Hospital of the Chinese People's Liberation Army Jinan, | Boehringer Ingelheim - (china@bitrialsupport.com) |
| Aichi Cancer Center Hospital Aichi, Nagoya, | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| Asan Medical Center Seoul, | Boehringer Ingelheim - (namhan@bitrialsupport.com) |
| Asklepios Fachkliniken München-Gauting Gauting, | |
| Chang Gung Memorial Hospital, Linkou Taoyuan District, | |
| Dana-Farber Cancer Institute Boston, Massachusetts | |
| Evangelische Lungenklinik Berlin Berlin, | |
| Freeman Hospital High Heaton, | Boehringer Ingelheim - (unitedkingdom@bitrialsupport.com) |
| H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| HOP Civil Strasbourg, | |
| HOP Intercommunal Créteil, | |
| Hopital Cochin Paris, | |
| Hospital CUF Descobertas-Lisboa-69316 Lisbon, | |
| Hospital Clinico Universitario de Valencia Valencia, | |
| Hospital Cuf porto Porto, | |
| Hospital Del Mar Barcelona, | |
| Hospital Universitari Vall d Hebron Barcelona, | Boehringer Ingelheim - (espana@bitrialsupport.com) |
| Hospital Universitario 12 de Octubre Madrid, | Boehringer Ingelheim - (espana@bitrialsupport.com) |
| Hospital Virgen de la Victoria Málaga, | Boehringer Ingelheim - (espana@bitrialsupport.com) |
| Indiana University Indianapolis, Indiana | |
| Infirmary Cancer Care Mobile, Alabama | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Japanese Foundation for Cancer Research Tokyo, Koto-ku, | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| Kindai University Hospital Sayama, Osaka | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| Laura & Isaac Perlmutter Cancer Center at NYU Langone Health New York, New York | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Leicester Royal Infirmary Leicester, | Boehringer Ingelheim - (unitedkingdom@bitrialsupport.com) |
| LungenClinic Grosshansdorf GmbH Großhansdorf, | |
| MHAT Heart and Brain Pleven, | |
| MHAT UniHospital Panagyurishte, | |
| Mayo Clinic Cancer Center Jacksonville, Florida | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Mayo Clinic, Rochester Rochester, Minnesota | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Mayo Clinic-Arizona Phoenix, Arizona | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Montefiore Medical Center The Bronx, New York | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| NCKUH Tainan, | |
| National Cancer Center Hospital ChuoKu, Tokyo | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| National Cancer Center Hospital East Chiba, Kashiwa, | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| Osaka International Cancer Institute Osaka, Osaka, | Boehringer Ingelheim - (nippon@bitrialsupport.com) |
| Qilu Hospital, Shangdong University Jinan, | Boehringer Ingelheim - (china@bitrialsupport.com) |
| Samsung Medical Center Seoul, | Boehringer Ingelheim - (namhan@bitrialsupport.com) |
| Sendai Kousei Hospital Miyagi, | |
| Severance Hospital Seoul, | Boehringer Ingelheim - (namhan@bitrialsupport.com) |
| Shanghai Chest Hospital Shanghai, | Boehringer Ingelheim - (china@bitrialsupport.com) |
| Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine Hangzhou, | Boehringer Ingelheim - (china@bitrialsupport.com) |
| Taipei Veterans General Hospital Taipei, Beitou District / R.o.c. | |
| The Christie Manchester, | Boehringer Ingelheim - (unitedkingdom@bitrialsupport.com) |
| The Second Affiliated Hospital to Nanchang University Nanchang, | Boehringer Ingelheim - (china@bitrialsupport.com) |
| UZ Leuven Leuven, | Boehringer Ingelheim - (belgique@bitrialsupport.com) |
| Universitair Ziekenhuis Gent Ghent, | Boehringer Ingelheim - (belgique@bitrialsupport.com) |
| University College Hospital London, | Boehringer Ingelheim - (unitedkingdom@bitrialsupport.com) |
| University of California San Francisco San Francisco, California | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| University of Kansas Cancer Center Kansas City, Kansas | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| University of Kentucky Medical Center Lexington, Kentucky | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| University of Maryland School of Medicine Baltimore, Maryland | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| University of Miami Miami, Florida | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Universitätsklinikum Carl Gustav Carus Dresden Dresden, | Boehringer Ingelheim - (deutschland@bitrialsupport.com) |
| Universitätsklinikum Erlangen Erlangen, | Boehringer Ingelheim - (deutschland@bitrialsupport.com) |
| Universitätsmedizin der Johannes Gutenberg-Universität Mainz Mainz, | Boehringer Ingelheim - (deutschland@bitrialsupport.com) |
| Valkyrie Clinical Trials Los Angeles, California | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| Virginia Commonwealth University Health- Adult Outpatient Pavilion Richmond, Virginia | Boehringer Ingelheim - (unitedstates@bitrialsupport.com) |
| West China Hospital of Sichuan University Chengdu, | Boehringer Ingelheim - (china@bitrialsupport.com) |
ALS/MND Natural History Study Data Repository
Natalia Tarasenko - ntarasenko@mgh.harvard.edu
NCT05966038
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* A clinical diagnosis of El Escorial of suspected, possible, probable, or definite ALS or
* Other motor neuron disorders, including but not limited to Spinal-Bulbar Muscular Atrophy (SBMA, Kennedy's disease), Spinal Muscular Atrophy (SMA), Primary Lateral Sclerosis (PLS), Progressive Muscular Atrophy (PMA), and Progressive Bulbar Palsy (PBP)
Exclusion Criteria:
* Disease does not meet criteria for any motor neuron disorder ALS, PLS, MND (Motor Neurone DIsease), Kennedy Disease, PMA - Progressive Muscular Atrophy, PBP - Progressive Bulbar Palsy
I'm interested
Share via email
Show 16 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Centro Clinico NEMO Milano Milan, | Monica Montuori - (monica.montuori@centrocliniconemo.it) |
| Hadassah Medical Organization Jerusalem, | Michal Zabari - (michalza@hadassah.org.il) |
| Henry Ford Health System Detroit, Michigan | Anne Vallis - (avallis1@hfhs.org) |
| Istituti Clinici Scientifici Maugeri SpA Milan, | Camilla Garrè - (camilla.garre@icsmaugeri.it) |
| Kaiser Permanente Fresno, California | Chris Greer - (chris.x.lindgren@kp.org) |
| Lahey Clinic Burlington, Massachusetts | Sorieba Fofanah - (Sorieba.Fofanah@lahey.org) Melo Catia - (catia.s.melo@lahey.org) |
| Loma Linda University Health Loma Linda, California | |
| Northwestern University Chicago, Illinois | Emma Schmidt - (emma.schmidt@northwestern.edu) |
| Providence ALS Clinic Portland, Oregon | Tyler Regan - (tyler.regan@providence.org) |
| Saint Louis University St Louis, Missouri | Katie Forsman - (katie.forsman@health.slu.edu) |
| Tel Aviv Medical Center Tel Aviv, | Beatrice Abramovich - (beatricen@tlvmc.gov.il) |
| Temple University Lewis Katz School of Medicine Philadelphia, Pennsylvania | John Furey - (john.furey0001@temple.edu) |
| University of Florida Gainesville, Florida | Jennifer Steshyn - (Jennifer.Steshyn@neurology.ufl.edu) |
| University of Minnesota Minneapolis, Minnesota | Valerie Ferment - (ferm0016@umn.edu) |
| University of Pittsburgh Pittsburgh, Pennsylvania | Helen Ismail - (ismailhh@upmc.edu) |
| Virginia Commonwealth University Richmond, Virginia | Demetrius Carter - (Demetrius.R.Carter@vcuhealth.org) |
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
ctrrecruit@vcu.edu
NCT06500455
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
* Pathologically (histologically or cytologically) proven diagnosis of one of the following solid tumor malignancies within 5 years prior to registration:
* Non-small cell lung cancer
* Melanoma
* Breast cancer
* Renal cell carcinoma
* Gastrointestinal cancer
* If the original histologic proof of malignancy is greater than 5 years, then more recent pathologic confirmation (e.g., from a systemic site or brain metastasis) or unequivocal imaging confirmation of extracranial metastatic disease (e.g. CT of the chest/abdomen/pelvis, positron emission tomography \[PET\]/CT, etc.) is required
* Patients must have at least 1 and up to 8 total intact brain metastases detected on a contrast-enhanced MRI performed ≤ 21 days prior to registration
* At least 1 of the up to 8 lesions must be a study eligible lesion, defined as lesion with a maximum diameter as measured on any orthogonal plane (axial, sagittal, coronal) of ≥ 1.0 cm and ≤ 3.0 cm
* All brain metastases must be located outside of the brainstem and ≥ 5 mm from the optic nerves or optic chiasm and ≤ 3.0 cm in maximum dimension
* Note: brainstem metastases per the MRI within 21 days of registration are an exclusion criterion; however, if the MRI used for treatment planning performed within 7 days of SRS/FSRS reveals a brainstem metastasis, the patient remains eligible if the patient is considered an appropriate radiosurgery candidate per the local investigator
* Patients must have a diagnosis-specific graded prognostic assessment ≥ 1.5
* No more than 2 lesions planned for resection if clinically indicated
* No known leptomeningeal disease (LMD)
* Note: For the purposes of exclusion, LMD is a clinical diagnosis, defined as positive cerebrospinal fluid (CSF) cytology and/or unequivocal radiologic or clinical evidence of leptomeningeal involvement. Patients with leptomeningeal symptoms in the setting of leptomeningeal enhancement by imaging (MRI) would be considered to have LMD even in the absence of positive CSF cytology. In contrast, an asymptomatic or minimally symptomatic patient with mild or nonspecific leptomeningeal enhancement (MRI) would not be considered to have LMD. In that patient, CSF sampling is not required to formally exclude LMD, but can be performed at the investigator's discretion based on level of clinical suspicion
* Age ≥ 18 years
* Karnofsky performance status (KPS) ≥ 60
* Negative urine or serum pregnancy test (in persons of childbearing potential) within 14 days prior to registration. Childbearing potential is defined as any person who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal
* No prior radiotherapy to the brain (partial or whole brain irradiation, SRS, FSRS, or prophylactic cranial irradiation \[PCI\])
* New York Heart Association Functional Classification II or better (NYHA Functional Classification III/IV are not eligible) (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification)
* No active infection currently requiring intravenous (IV) antibiotic management
* No hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
* No chronic obstructive pulmonary disease exacerbation or other acute respiratory illness precluding study therapy PROCEDURE: Computed Tomography, RADIATION: Fractionated Stereotactic Radiation Therapy, PROCEDURE: Magnetic Resonance Imaging, RADIATION: Stereotactic Radiosurgery
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Digestive System Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Metastatic Renal Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
I'm interested
Share via email
Show 234 locations
Study Locations
Hide all locations
| Location | Contacts |
|---|---|
| Aspirus Cancer Care - James Beck Cancer Center Rhinelander, Wisconsin | Site Public Contact - (Beth.Knetter@aspirus.org) |
| Aspirus Cancer Care - Stevens Point Stevens Point, Wisconsin | Site Public Contact - (Beth.Knetter@aspirus.org) |
| Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids, Wisconsin | |
| Aspirus Regional Cancer Center Wausau, Wisconsin | |
| Banner University Medical Center - Tucson Tucson, Arizona | Site Public Contact - (UACC-IIT@uacc.arizona.edu) |
| Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston, Texas | Site Public Contact - (burton@bcm.edu) |
| Boca Raton Regional Hospital Boca Raton, Florida | |
| Cancer Care Center of O'Fallon O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Care Specialists of Illinois - Decatur Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Cancer Care and Hematology-Fort Collins Fort Collins, Colorado | Site Public Contact - (Roster@nrgoncology.org) |
| Carle Cancer Center Urbana, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Effingham Effingham, Illinois | Site Public Contact - (Research@carle.com) |
| Carle Physician Group-Mattoon/Charleston Mattoon, Illinois | Site Public Contact - (Research@carle.com) |
| Carle at The Riverfront Danville, Illinois | Site Public Contact - (Research@Carle.com) |
| Case Western Reserve University Cleveland, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| Castle Medical Center Kailua, Hawaii | |
| Cedars Sinai Medical Center Los Angeles, California | |
| Central Maryland Radiation Oncology in Howard County Columbia, Maryland | |
| Centralia Oncology Clinic Centralia, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Chambersburg Hospital Chambersburg, Pennsylvania | Site Public Contact - (Roster@nrgoncology.org) |
| City of Hope Antelope Valley Lancaster, California | Site Public Contact - (becomingapatient@coh.org) |
| City of Hope Comprehensive Cancer Center Duarte, California | Site Public Contact - (becomingapatient@coh.org) |
| City of Hope Corona Corona, California | Site Public Contact - (becomingapatient@coh.org) |
| City of Hope South Bay Torrance, California | |
| City of Hope South Pasadena South Pasadena, California | Site Public Contact - (becomingapatient@coh.org) |
| City of Hope Upland Upland, California | Site Public Contact - (becomingapatient@coh.org) |
| City of Hope at Irvine Lennar Irvine, California | |
| Clackamas Radiation Oncology Center Clackamas, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Coborn Cancer Center at Saint Cloud Hospital Saint Cloud, Minnesota | Site Public Contact - (coborncancercenter@centracare.com) |
| Community Medical Center Missoula, Montana | Site Public Contact - (Lennette.Gonzales@rwjbh.org) |
| Crossroads Cancer Center Effingham, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Decatur Memorial Hospital Decatur, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Delaware Health Center-Grady Cancer Center Delaware, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Edward Hospital/Cancer Center Naperville, Illinois | |
| Elmhurst Memorial Hospital Elmhurst, Illinois | Site Public Contact - (Jrohde@emhc.org) |
| Emory Saint Joseph's Hospital Atlanta, Georgia | |
| Emory University Hospital Midtown Atlanta, Georgia | |
| Emory University Hospital/Winship Cancer Institute Atlanta, Georgia | |
| Goshen Center for Cancer Care Goshen, Indiana | Site Public Contact - (cccois@goshenhealth.com) |
| Grady Memorial Hospital Delaware, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Grant Medical Center Columbus, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Gundersen Lutheran Medical Center La Crosse, Wisconsin | Site Public Contact - (cancerctr@gundersenhealth.org) |
| HSHS Saint Elizabeth's Hospital O'Fallon, Illinois | Site Public Contact - (morganthaler.jodi@mhsil.com) |
| Hartford Hospital Hartford, Connecticut | |
| Hawaii Cancer Care - Westridge ‘Aiea, Hawaii | Site Public Contact - (info@hawaiicancercare.com) |
| Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii | Site Public Contact - (i.webster@hawaiicancercare.com) |
| Henry Ford Hospital Detroit, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Huntsman Cancer Institute/University of Utah Salt Lake City, Utah | Site Public Contact - (cancerinfo@hci.utah.edu) |
| Indu and Raj Soin Medical Center Beavercreek, Ohio | |
| Jefferson Torresdale Hospital Philadelphia, Pennsylvania | Site Public Contact - (ONCTrialNow@jefferson.edu) |
| Jersey Shore Medical Center Neptune City, New Jersey | |
| John Muir Medical Center-Walnut Creek Walnut Creek, California | Site Public Contact - (clinicalresearch@johnmuirhealth.com) |
| Kaiser Permanente Los Angeles Medical Center Los Angeles, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Anaheim Anaheim, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Bellflower Bellflower, California | Site Public Contact - (clinical.trials@kp.org) |
| Kaiser Permanente-Ontario Ontario, California | Site Public Contact - (clinical.trials@kp.org) |
| Kapiolani Medical Center for Women and Children Honolulu, Hawaii | |
| Kettering Medical Center Kettering, Ohio | |
| Langlade Hospital and Cancer Center Antigo, Wisconsin | Site Public Contact - (Juli.Alford@aspirus.org) |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York | Site Public Contact - (CancerTrials@nyulangone.org) |
| Legacy Cancer Institute Medical Oncology and Day Treatment Vancouver, Washington | Site Public Contact - (oncologyresearch@lhs.org) |
| Legacy Good Samaritan Hospital and Medical Center Portland, Oregon | Site Public Contact - (cancer@lhs.org) |
| Legacy Meridian Park Hospital Tualatin, Oregon | |
| Legacy Mount Hood Medical Center Gresham, Oregon | |
| Legacy Salmon Creek Hospital Vancouver, Washington | |
| Loyola University Medical Center Maywood, Illinois | |
| M D Anderson Cancer Center Houston, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson League City League City, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson West Houston Houston, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson in Sugar Land Sugar Land, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MD Anderson in The Woodlands Conroe, Texas | Site Public Contact - (askmdanderson@mdanderson.org) |
| MU Health - University Hospital/Ellis Fischel Cancer Center Columbia, Missouri | |
| MaineHealth Cancer Care Center of York County Sanford, Maine | |
| MaineHealth Maine Medical Center - Portland Portland, Maine | Site Public Contact - (clinicalresearch@mainehealth.org) |
| MaineHealth Maine Medical Center- Scarborough Scarborough, Maine | Site Public Contact - (clinicalresearch@mainehealth.org) |
| Mary Greeley Medical Center Ames, Iowa | |
| Maryland Proton Treatment Center Baltimore, Maryland | Site Public Contact - (info@mdproton.com) |
| McFarland Clinic - Ames Ames, Iowa | Site Public Contact - (ksoder@mcfarlandclinic.com) |
| Medical Center of the Rockies Loveland, Colorado | |
| Medical College of Wisconsin Milwaukee, Wisconsin | |
| Memorial Hermann Texas Medical Center Houston, Texas | |
| Memorial Hospital East Shiloh, Illinois | Site Public Contact - (dschwab@wustl.edu) |
| Memorial Hospital North Colorado Springs, Colorado | |
| Memorial Sloan Kettering Basking Ridge Basking Ridge, New Jersey | |
| Memorial Sloan Kettering Bergen Montvale, New Jersey | |
| Memorial Sloan Kettering Cancer Center New York, New York | |
| Memorial Sloan Kettering Commack Commack, New York | |
| Memorial Sloan Kettering Monmouth Middletown, New Jersey | |
| Memorial Sloan Kettering Nassau Uniondale, New York | |
| Memorial Sloan Kettering Westchester Harrison, New York | |
| Mercy Hospital Springfield Springfield, Missouri | |
| Miami Cancer Institute Miami, Florida | |
| Moffitt Cancer Center Tampa, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Moffitt Cancer Center - McKinley Campus Tampa, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Moffitt Cancer Center at Wesley Chapel Wesley Chapel, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Moffitt Cancer Center-International Plaza Tampa, Florida | Site Public Contact - (ClinicalTrials@moffitt.org) |
| Montefiore Medical Center - Moses Campus The Bronx, New York | Site Public Contact - (eskwak@montefiore.org) |
| Montefiore Medical Center-Einstein Campus The Bronx, New York | Site Public Contact - (eskwak@montefiore.org) |
| Montefiore Medical Center-Weiler Hospital The Bronx, New York | Site Public Contact - (eskwak@montefiore.org) |
| Monticello Cancer Center Monticello, Minnesota | Site Public Contact - (mmcorc@healthpartners.com) |
| Mount Sinai Chelsea New York, New York | Site Public Contact - (CCTO@mssm.edu) |
| Mount Sinai Hospital New York, New York | Site Public Contact - (CCTO@mssm.edu) |
| Mount Sinai West New York, New York | Site Public Contact - (CCTO@mssm.edu) |
| MyMichigan Medical Center Saginaw Saginaw, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| MyMichigan Medical Center Tawas Tawas City, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| NRG Oncology Philadelphia, Pennsylvania | Rupesh R. Kotecha - (rupeshk@baptisthealth.net) |
| NYU Langone Hospital - Brooklyn Brooklyn, New York | Site Public Contact - (david.wallach@nyulangone.org) |
| NYU Langone Hospital - Long Island Mineola, New York | Site Public Contact - (cancertrials@nyulangone.org) |
| Nebraska Medicine-Bellevue Bellevue, Nebraska | Site Public Contact - (unmcrsa@unmc.edu) |
| Nebraska Medicine-Village Pointe Omaha, Nebraska | |
| Newark Beth Israel Medical Center Newark, New Jersey | Site Public Contact - (Christine.Kosmides@rwjbh.org) |
| Northeast Radiation Oncology Center Dunmore, Pennsylvania | |
| Northwest Cancer Center - Hobart Hobart, Indiana | |
| Northwest Cancer Center - Main Campus Crown Point, Indiana | |
| Northwest Cancer Center - Valparaiso Valparaiso, Indiana | Site Public Contact - (CancerResearch@COMHS.org) |
| Northwest Oncology LLC Dyer, Indiana | |
| Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois | Site Public Contact - (Donald.Smith3@nm.org) |
| Northwestern University Chicago, Illinois | Site Public Contact - (cancer@northwestern.edu) |
| Ohio State University Comprehensive Cancer Center Columbus, Ohio | Site Public Contact - (Jamesline@osumc.edu) |
| Owensboro Health Mitchell Memorial Cancer Center Owensboro, Kentucky | Site Public Contact - (vanissa.sorrels@owensborohealth.org) |
| Pamela Youde Nethersole Eastern Hospital Hong Kong, | |
| Parkland Health Center - Farmington Farmington, Missouri | |
| Penn State Milton S Hershey Medical Center Hershey, Pennsylvania | Site Public Contact - (CTO@hmc.psu.edu) |
| Piedmont Hospital Atlanta, Georgia | Site Public Contact - (ORS@piedmont.org) |
| Poudre Valley Hospital Fort Collins, Colorado | |
| Providence Medical Foundation - Santa Rosa Santa Rosa, California | |
| Providence Portland Medical Center Portland, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Providence Queen of The Valley Napa, California | |
| Providence Saint Vincent Medical Center Portland, Oregon | Site Public Contact - (CanRsrchStudies@providence.org) |
| Queen's Cancer Cenrer - POB I Honolulu, Hawaii | |
| Queen's Cancer Center - Kuakini Honolulu, Hawaii | |
| Queen's Medical Center Honolulu, Hawaii | |
| Reading Hospital West Reading, Pennsylvania | |
| Renown Regional Medical Center Reno, Nevada | Site Public Contact - (research@sncrf.org) |
| Riverside Methodist Hospital Columbus, Ohio | Site Public Contact - (Jennifer.Sexton@ohiohealth.com) |
| Rush MD Anderson Cancer Center Chicago, Illinois | Site Public Contact - (Cancer_Studies@rush.edu) |
| Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey | |
| SUNY Upstate Medical Center-Community Campus Syracuse, New York | |
| Saint Barnabas Medical Center Livingston, New Jersey | Site Public Contact - (joanne.loeb@rwjbh.org) |
| Saint Elizabeth Youngstown Hospital Youngstown, Ohio | |
| Saint Luke's Cancer Center - Allentown Allentown, Pennsylvania | |
| Saint Luke's Hospital - Upper Bucks Campus Quakertown, Pennsylvania | |
| Saint Luke's University Hospital-Bethlehem Campus Bethlehem, Pennsylvania | |
| Saint Mary Medical Center Hobart, Indiana | Site Public Contact - (CancerResearch@COMHS.org) |
| Sanford Broadway Medical Center Fargo, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota | Site Public Contact - (OncologyClinicTrialsSF@sanfordhealth.org) |
| Sanford Roger Maris Cancer Center Fargo, North Dakota | Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org) |
| Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota | Site Public Contact - (OncologyClinicalTrialsSF@SanfordHealth.org) |
| Sidney Kimmel Cancer Center Washington Township Sewell, New Jersey | Site Public Contact - (ONCTrialNow@jefferson.edu) |
| Sinai Hospital of Baltimore Baltimore, Maryland | |
| Siteman Cancer Center at Christian Hospital St Louis, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Siteman Cancer Center at Saint Peters Hospital City of Saint Peters, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Siteman Cancer Center at West County Hospital Creve Coeur, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Siteman Cancer Center-South County St Louis, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Southern Illinois University School of Medicine Springfield, Illinois | |
| Springfield Clinic Springfield, Illinois | |
| Springfield Memorial Hospital Springfield, Illinois | Site Public Contact - (pallante.beth@mhsil.com) |
| Stanford Cancer Institute Palo Alto Palo Alto, California | Site Public Contact - (ccto-office@stanford.edu) |
| State University of New York Upstate Medical University Syracuse, New York | |
| Stony Brook University Medical Center Stony Brook, New York | |
| The Community Hospital Munster, Indiana | |
| The Hospital of Central Connecticut New Britain, Connecticut | |
| The James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky | |
| The Queen's Medical Center - West Oahu ‘Ewa Beach, Hawaii | Site Public Contact - (rohta@queens.org) |
| The Research Institute of the McGill University Health Centre (MUHC) Montreal, Quebec | Site Public Contact - (evelyn.ortega@muhc.mcgill.ca) |
| The University of Kansas Cancer Center - Olathe Olathe, Kansas | Site Public Contact - (OlatheCCResearch@kumc.edu) |
| The Valley Hospital - Luckow Pavilion Paramus, New Jersey | Site Public Contact - (clinicaltrialsresearch@valleyhealth.com) |
| ThedaCare Regional Cancer Center Appleton, Wisconsin | Site Public Contact - (ResearchDept@thedacare.org) |
| Thomas Jefferson University Hospital Philadelphia, Pennsylvania | Site Public Contact - (ONCTrialNow@jefferson.edu) |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan | Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org) |
| UC Comprehensive Cancer Center at Silver Cross New Lenox, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California | Site Public Contact - (ucstudy@uci.edu) |
| UC San Diego Health System - Encinitas Encinitas, California | |
| UC San Diego Medical Center - Hillcrest San Diego, California | Site Public Contact - (rhabbaba@health.ucsd.edu) |
| UC San Diego Moores Cancer Center La Jolla, California | Site Public Contact - (cancercto@ucsd.edu) |
| UCHealth Greeley Hospital Greeley, Colorado | Site Public Contact - (Roster@nrgoncology.org) |
| UCHealth Memorial Hospital Central Colorado Springs, Colorado | |
| UCHealth University of Colorado Hospital Aurora, Colorado | |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine, California | Site Public Contact - (ucstudy@uci.edu) |
| UChicago Medicine Northwest Indiana Crown Point, Indiana | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| UH Seidman Cancer Center at Lake Health Mentor Campus Mentor, Ohio | Site Public Contact - (CTUReferral@UHhospitals.org) |
| UH Seidman Cancer Center at UH Avon Health Center Avon, Ohio | |
| UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie, Maryland | |
| UM Capital Region Medical Center Largo, Maryland | Site Public Contact - (Sarah.Larson@umm.edu) |
| UM Sylvester Comprehensive Cancer Center at Aventura Aventura, Florida | |
| UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables, Florida | |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach, Florida | |
| UM Sylvester Comprehensive Cancer Center at Doral Doral, Florida | Site Public Contact - (kginnity@med.miami.edu) |
| UM Sylvester Comprehensive Cancer Center at Kendall Miami, Florida | |
| UM Sylvester Comprehensive Cancer Center at Plantation Plantation, Florida | |
| UM Upper Chesapeake Medical Center Bel Air, Maryland | |
| UPMC-Presbyterian Hospital Pittsburgh, Pennsylvania | |
| UPMC-Shadyside Hospital Pittsburgh, Pennsylvania | |
| University of Arizona Cancer Center-North Campus Tucson, Arizona | Site Public Contact - (UACC-IIT@uacc.arizona.edu) |
| University of Arkansas for Medical Sciences Little Rock, Arkansas | |
| University of Chicago Comprehensive Cancer Center Chicago, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| University of Chicago Medicine-Orland Park Orland Park, Illinois | Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu) |
| University of Cincinnati Cancer Center-UC Medical Center Cincinnati, Ohio | Site Public Contact - (cancer@uchealth.com) |
| University of Cincinnati Cancer Center-West Chester West Chester, Ohio | Site Public Contact - (cancer@uchealth.com) |
| University of Hawaii Cancer Center Honolulu, Hawaii | |
| University of Kansas Cancer Center Kansas City, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kansas Cancer Center-Overland Park Overland Park, Kansas | Site Public Contact - (KUCC_Navigation@kumc.edu) |
| University of Kentucky/Markey Cancer Center Lexington, Kentucky | |
| University of Maryland Shore Medical Center at Easton Easton, Maryland | Site Public Contact - (Christina.weisenborn@umm.edu) |
| University of Maryland/Greenebaum Cancer Center Baltimore, Maryland | |
| University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida | |
| University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan | Site Public Contact - (slusserb@med.umich.edu) |
| University of Nebraska Medical Center Omaha, Nebraska | Site Public Contact - (unmcrsa@unmc.edu) |
| University of New Mexico Cancer Center Albuquerque, New Mexico | Site Public Contact - (HSC-ClinicalTrialInfo@salud.unm.edu) |
| University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma | Site Public Contact - (ou-clinical-trials@ouhsc.edu) |
| University of Pennsylvania/Abramson Cancer Center Philadelphia, Pennsylvania | Site Public Contact - (PMCancerResearch@pennmedicine.upenn.edu) |
| University of Rochester Rochester, New York | |
| University of Texas Health Science Center at San Antonio San Antonio, Texas | Site Public Contact - (phoresearchoffice@uthscsa.edu) |
| University of Vermont Medical Center Burlington, Vermont | Site Public Contact - (rpo@uvm.edu) |
| University of Vermont and State Agricultural College Burlington, Vermont | Site Public Contact - (rpo@uvm.edu) |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison, Wisconsin | Site Public Contact - (clinicaltrials@cancer.wisc.edu) |
| University of Wisconsin Carbone Cancer Center - University Hospital Madison, Wisconsin | Site Public Contact - (clinicaltrials@cancer.wisc.edu) |
| UofL Health Medical Center Northeast Louisville, Kentucky | Site Public Contact - (ctoinfo@louisville.edu) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| Valley Health System Ridgewood Campus Ridgewood, New Jersey | Site Public Contact - (clinicaltrialsresearch@valleyhealth.com) |
| Valley Medical Center Renton, Washington | Site Public Contact - (research@valleymed.org) |
| Vanderbilt Breast Center at One Hundred Oaks Nashville, Tennessee | |
| Vanderbilt University/Ingram Cancer Center Nashville, Tennessee | |
| Washington University School of Medicine St Louis, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| WellSpan Health-York Cancer Center York, Pennsylvania | |
| WellSpan Health-York Hospital York, Pennsylvania | |
| WellStar Cobb Hospital Austell, Georgia | Site Public Contact - (research@wellstar.org) |
| Wellstar Kennestone Hospital Marietta, Georgia | Site Public Contact - (research@wellstar.org) |
| Wilcox Memorial Hospital and Kauai Medical Clinic Lihue, Hawaii | |
| William E Kahlert Regional Cancer Center/Sinai Hospital Westminster, Maryland | |
| Women's Diagnostic Center - Munster Munster, Indiana | Site Public Contact - (mnicholson@comhs.org) |