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Breast Colon Colorectal Leukemia Lymphoma Myeloma Ovarian Pancreatic Prostate

123 Study Matches

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

Contact(s):

BMS Study Connect Contact Center www.BMSStudyConnect.com - Clinical.Trials@bms.com

Principal Investigator:

System ID: NCT04094610

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Key

Inclusion Criteria:

• Documented genetic ROS1 point mutation, fusion, or amplification or NTRK1-3 fusion as identified by local testing in a Clinical Laboratory Improvement Amendments (CLIA) laboratory in the US or equivalently accredited diagnostic lab outside the United States (US) is required.
• Phase 1: Age \<12 years; Phase 2: Age 12- 25 years
• Prior cytotoxic chemotherapy is allowed.
• Prior immunotherapy is allowed.
• Resolution of all acute toxic effects (excluding alopecia) of any prior anti-cancer therapy to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version 4.03 Grade less than or equal to 1.
• All subjects must have measurable disease by RECIST v1.1 or Response Assessment in Neuro-Oncology (RANO) criteria at time of enrollment.
• Subjects with a primary CNS tumor or CNS metastases must be neurologically stable on a stable or decreasing dose of steroids for at least 7 days prior to enrollment.
• Subjects must have a Lansky (\< 16 years) or Karnofsky (≥ 16 years) score of at least 50.
• Life expectancy greater than or equal to 12 weeks, in the investigator's opinion.
• Adequate hematologic, renal and hepatic function. Phase 2

Inclusion Criteria:

• Cohort Specific

Inclusion Criteria:

* Cohort 1: Subjects with NTRK fusion gene positive (NTRK+) advanced solid tumors (including primary CNS tumors), that are tropomyosin receptor kinase (TRK) TKI naïve; * Cohort 2: subjects with NTRK+ advanced solid tumors (including primary CNS tumors), that are TRK TKI pre-treated; * Cohort 3: subjects with advanced solid tumors with ROS1 gene fusions or other ROS1 aberrations (including amplifications and point mutations) with measurable disease.
• Subjects in Cohorts 1 and 2 must have prospectively confirmed measurable disease by BICR prior to enrollment. Key Exclusion Criteria (Phase 1 and Phase 2):
• Subjects with neuroblastoma with only bone marrow disease evaluable by bone marrow aspiration only.
• Major surgery within 14 days (2 weeks) of start of repotrectinib treatment. Central venous access (Broviac, Mediport, etc.) placement does not meet criteria for major surgery.
• Known active infections requiring ongoing treatment (bacterial, fungal, viral including HIV positivity).
• Gastrointestinal disease (e.g., Crohn's disease, ulcerative colitis, or short gut syndrome) or other malabsorption syndromes that would impact drug absorption.
• Any of the following cardiac criteria: * Mean resting corrected QT interval (ECG interval measured from the onset of the QRS complex to the end of the T wave) for heart rate (QTc) \> 480 msec obtained from three ECGs, using the screening clinic ECG machine-derived QTc value * Any clinically important abnormalities in rhythm, conduction, or morphology of resting ECG (e.g., complete left bundle branch block, third degree heart block, second degree heart block, PR interval \> 250 msec) * Any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, congenital long QT syndrome, family history of long QT syndrome, or any concomitant medication known to prolong the QT interval
• Peripheral neuropathy of CTCAE ≥grade 2.
• Subjects being treated with or anticipating the need for treatment with strong CYP3A4 inhibitors or inducers.
• Any potential allergies to repotrectinib and/or its excipients.

Interventions: DRUG: Oral repotrectinib (TPX-0005)

Conditions: Locally Advanced Solid Tumors, Metastatic Solid Tumors, Lymphoma, Primary CNS Tumors

Keywords: ALK, ROS1, NTRK1-3, Primary CNS tumor, anaplastic large cell lymphoma, metastatic solid tumor, advanced solid tumor, sarcoma, infantile fibrosarcoma, glioblastoma, soft tissue schwannoma, solitary fibrous tumor, glioma, inflammatory myofibroblastic tumor, pediatric

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Study Locations

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Location	Contacts
Alder Hey Children's NHS Foundation Trust Liverpool, England
Asan Medical Center Seoul,
Baylor College of Medicine Houston, Texas
Centre Hospitalier Universitaire d'Angers Angers, Maine-et-Loire
Centre Hospitalier Universitaire de Bordeaux - Groupe Hospitalier Pellegrin Bordeaux,
Children's Health Queensland Hospital and Health Service South Brisbane, Queensland
Children's Healthcare of Atlanta - Egleston Hospital Atlanta, Georgia
Children's Hospital Colorado - Anschutz Medical Campus Aurora, Colorado
Children's Hospital Los Angeles Los Angeles, California
Children's Hospital Of Eastern Ontario Ottawa, Ontario
Children's Hospital of Philadelphia-Center for Childhood Cancer Research Philadelphia, Pennsylvania
Children's Hospital of Richmond at VCU Richmond, Virginia
Clinica Universidad de Navarra Madrid,
Clinica Universidad de Navarra Madrid,
Dana Farber Cancer Institute. Boston, Massachusetts
Fondazione IRCCS - Istituto Nazionale dei Tumori Milan,
Great Ormond Street Hospital for Children NHS Foundation Trust London,
HM Sanchinarro University Hospital Madrid,
Hospital Infantil Universitario Nino Jesus Madrid,
Hospital Sant Joan de Deu Barcelona,
Hospital Universitari Vall d'Hebron Barcelona,
Hospital Universitario Virgen del Rocio Seville,
Hospital Universitario y Politécnico La Fe Valencia,
Hôpitaux Universitaires de Marseille Timone Marseille,
Institut Gustave-Roussy Villejuif, FR
Institut d Hematologie et d Oncologie Pediatriques Lyon,
KK Women's and Children's Hospital Singapore,
Levine Children's Hospital- Pediatric Neuro-Oncology Charlotte, North Carolina
Local Institution - 2102 New York, New York
Local Institution - 2104 Houston, Texas
Local Institution - 2105 Orlando, Florida
Local Institution - 2110 New Brunswick, New Jersey
Local Institution - 2112 Cleveland, Ohio
Local Institution - 2114 Hershey, Pennsylvania
Local Institution - 2120 Orlando, Florida
Local Institution - 4302 Rome,
Local Institution - 4403 Birmingham,
Local Institution - 6103 Westmead, New South Wales
Local Institution - 6104 Randwick, New South Wales
Local Institution - 6105 Barcelona,
Local Institution - 6106 Madrid,
Local Institution - 6107 Valencia,
Local Institution - 6108 Villejuif,
Local Institution - 6109 Paris,
Local Institution - 6110 Marseille,
Local Institution - 6111 Lyon, Rhone
Local Institution - 6112 Nantes,
Local Institution - 6113 Padua,
Local Institution - 6114 Torino,
Local Institution - 6303 Seoul, Seodaemun-gu
Local Institution - 6304 Seoul,
Maine Medical Center Portland, Maine
National Taiwan University Hospital Taipei,
National University Hospital Singapore,
Perth Childrens Hospital Nedlands, Western Australia
Rigshospitalet - Glostrup Copenhagen,
Royal Hosp. for Children Glasgow,
Seoul National University Hospital Seoul,
St Justine Hospital Montreal, Quebec
St. Jude Children's Research Hospital Memphis, Tennessee
Stollery Children's Hospital Edmonton, Alberta
Taipei Medical University Hospital Taipei,
The Royal Marsden NHS Foundation Trust Sutton,
The University of Texas Southwestern Medical Center - Harold C Simmons Comprehensive Cancer Center Dallas, Texas
University Hospital of Wales Cardiff,
University of Calgary Calgary, Alberta
University of California at Los Angeles Los Angeles, California
Washington University School of Medicine in St. Louis St Louis, Missouri

National Liver Cancer Screening Trial (TRACER)

Contact(s):

Amit Singal, MD, MS - Amit.Singal@UTSouthwestern.edu

Principal Investigator:

System ID: NCT06084234

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Inclusion Criteria:

Patient must meet all of the following inclusion criteria:
• Adult patients ages 18-85 with cirrhosis from any etiology or with chronic hepatitis B with a PAGE-B score greater than 9 within 12 months of enrollment
• Patient is eligible for HCC surveillance according to treating physician or by the site investigator
• Able to provide informed consent
• Life expectancy \>6 months (after consent) as determined by the treating provider or site investigator

Exclusion Criteria:

Patient will be excluded for any of the following exclusion criteria:
• Child Pugh C cirrhosis
• History or clinical symptoms of hepatocellular carcinoma or cholangiocarcinoma
• History of solid nodule on baseline ultrasound (i.e., lesion 1cm or greater) within 9 months prior to consent without subsequent diagnostic CT/MRI demonstrating benign nature)
• AFP \>20 ng/mL within 6 months prior to consent, in the absence of a contrast-enhanced CT or MRI within 6 months of AFP (before or after) level demonstrating lack of suspicious liver lesions
• Newly diagnosed LR-3 greater than or equal to 1 cm within 6 months prior to consent
• History of LR-4, LR-5, or LR-M on multi-phase CT or contrast-enhanced MRI within 6 months prior to consent
• Presence of another active cancer besides non-melanomatous skin cancer or indolent cancer under active surveillance (e.g., prostate cancer or renal cell carcinoma) within the 2 years prior to consent
• Patient's provider is planning to use MRI- or CT- based surveillance moving forward
• History of a transjugular intrahepatic portosystemic shunt (TIPS)
• History of Fontan associated liver disease or cardiac cirrhosis
• History of solid organ transplantation
• Actively listed for liver transplantation
• Diagnosis of alcohol-associated hepatitis within 3 months prior to consent
• Documented current or continued signs and symptoms of acute Wilson disease (acute liver failure, acute neurological deficits, hemolysis)
• In patients with primary sclerosing cholangitis (PSC): Current active cholangitis within 90 days prior to consent
• Known or documented habitual non-adherence to previous research studies or medical procedures or unwillingness to adhere to protocol (e.g., unwilling to obtain consent or samples)
• In patients living with HIV: CD4+ T cell count less than 100 cells/mm3 within 60 days prior to consent
• Known pregnancy at consent
• Active warfarin use

Interventions: DIAGNOSTIC_TEST: GALAD, DIAGNOSTIC_TEST: Liver Ultrasound with or without AFP

Conditions: Carcinoma, Hepatocellular, Liver Cancer, Liver Cirrhosis, Hepatitis B

Keywords: Hepatocellular carcinoma surveillance, GALAD, Alpha Fetoprotein

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Study Locations

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Location	Contacts
Baylor College of Medicine Houston, Texas	Emad Sorial - (Emad.Sorial@bcm.edu) - (Sara.Fares@bcm.edu)
Case Western Reserve University Cleveland, Ohio	Pierre Gholam, MD - (pierre.gholam@case.edu) Paul Harris - (Paul.Harris2@UHhospitals.org)
Hennepin Healthcare Minneapolis, Minnesota	Jose Debes, MD - (debes003@umn.edu) Daniel Akah - (Dakah@bermancenter.org)
Henry Ford Health System Detroit, Michigan	Jessica Peruski - (jperusk1@hfhs.org)
Indiana University Indianapolis, Indiana	Sherri Cummins - (shcummin@iu.edu)
Kaiser Permanente Fresno, California	Sreepriya Balasubramanian, MD, MPH - (Sreepriya.Balasubramanian@kp.org) Quyen Chau - (Quyen.X.Chau@kp.org)
Massachusetts General Hospital Boston, Massachusetts	Megan Michta - (MMICHTA@mgh.harvard.edu)
Northwestern University Chicago, Illinois	Laura Kulik, MD - (laura.kulik@nm.org) Kimberly Sipich - (k-sipich@northwestern.edu)
Stanford University Palo Alto, California	Paul Kwo, MD - (pkwo@stanford.edu) Jennifer Smart - (Jsmart2@stanford.edu)
The Feinstein Institutes, Northwell Health, Inc. Manhasset, New York	Dibnain Nanda - (dnanda1@northwell.edu)
UT Southwestern Medical Center and Parkland Hospital Dallas, Texas	Sneha Deodhar, MS - (TRACER@UTSouthwestern.edu)
University of California, San Francisco San Francisco, California	Rae Davis - (rayshawnda.davis@ucsf.edu)
University of Michigan Ann Arbor, Michigan	Shay Robison - (roshay@med.umich.edu)
University of Minnesota Minneapolis, Minnesota	Elizabeth Aby, MD - (abyxx002@umn.edu) Erin Wesley - (wesle091@umn.edu)
University of North Carolina Chapel Hill, North Carolina	Andrew Moon, MD - (Andrew.Moon@unchealth.unc.edu) Bhagyashree Behera - (BB_Behera@med.unc.edu)
University of Pennsylvania Philadelphia, Pennsylvania	Grace Kim - (gracekim.lee@pennmedicine.upenn.edu)
University of Southern California Los Angeles, California
Virginia Commonwealth University Richmond, Virginia	Hannah Lee, MD - (Hannah.Lee@vcuhealth.org) Hannah Cook - (Hannah.Cook1@vcuhealth.org)

Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)

Contact(s):

Massey IIT Research Operations - masseyepd@vcu.edu

Principal Investigator:

System ID: NCT06731413

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Inclusion Criteria:

* Histologically or cytologically confirmed diagnosis of non-small cell lung cancer (NSCLC) (either squamous or non- squamous) * Stage IV disease OR have recurrent disease and not be candidates for curative treatment such as combined chemo-radiation * No previous line of treatment in the recurrent or metastatic setting. Neoadjuvant or adjuvant treatment more than 6 months before enrollment is acceptable. * Age 70 or meeting frailty definition or above at the date of signing informed consent * Absence of driver mutations that have first line Food and Drug Administration (FDA) approved targeted therapy * PD-L1 tumor proportion score (TPS) of less than 50% * Eastern Cooperative Oncology Group (ECOG) PS of 0-3 * Have measurable disease based on RECIST 1.1 as determined by the local site investigator/radiology assessment * Absolute neutrophil count (ANC) ≥ 1,000/μL * Platelets ≥ 75,000/μL * Hemoglobin (Hgb) ≥ 8.0 g/dL (transfusion permitted) * Total bilirubin ≤ 2 x institutional upper limit of normal (ULN) * Aspartate amino transferase (AST)serum glutamic-oxaloacetic transaminase (SGOT) /alanine aminotransferase (ALT)serum glutamic-pyruvic transaminase (SGPT) ≤ 5.0 × institutional ULN * Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

* Participants with life expectancy of less than 3 months at the time of enrollment * Has active autoimmune disease that has required systemic treatment in past 2 years (ie, with use of disease modifying agents, or immunosuppressive drugs) * Diagnosis of interstitial lung disease * Creatinine clearance of \<30 mL/min * Symptomatic, untreated central nervous system (CNS) disease or leptomeningeal disease. Patients with asymptomatic or treated CNS disease are eligible * Required ongoing use of immunosuppressive medication, including steroids, with the following allowable exceptions: * Doses less than or equal to the equivalent of prednisone 10 mg daily * Short courses of steroids that are discontinued prior to enrollment * Inhaled, intranasal and/or topical steroids * Dexamethasone taper for treating vasogenic edema associated with CNS disease

Interventions: DRUG: Reduced Dose of Chemotherapy and Immunotherapy

Conditions: Non-small Cell Lung Cancer, NSCLC, Advanced Non-small Cell Lung Cancer, Metastatic Non Small Cell Lung Cancer

Keywords: Non-Small Cell Lung Cancer, NSCLC

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Location	Contacts
Virginia Commonwealth University Richmond, Virginia	Massey Lung Team - (masseylung@vcu.edu)

Behavioral Exercise Training to Reduce Cardiovascular Disease Risk (EXTRA-PC)

Contact(s):

Alexander R Lucas, PhD - Alexander.Lucas@vcuhealth.org

Principal Investigator:

System ID: NCT06237179

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Interventions: BEHAVIORAL: Exercise Training Intervention, BEHAVIORAL: Healthy Living Education

Conditions: Prostate Cancer, Supportive Care

Keywords: Prostate Cancer, Supportive Care, Exercise

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Study Locations

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Location	Contacts
Richmond Veterans Affairs Medical Center Richmond, Virginia	Alexander R Lucas, PhD - (Alexander.Lucas2@va.gov) Alexandra L Marshall, MS - (lara.marshall@vcuhealth.org)
Virginia Commonwealth University Massey Cancer Center Richmond, Virginia	Alexandra Marshall - (marshallla@vcu.edu) Alexander Lucas, PhD - (Alexander.Lucas@vcuhealth.org)

Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

Contact(s):

Anne Beaven, MD - anne_beaven@med.unc.edu

Principal Investigator:

System ID: NCT05976763

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Inclusion Criteria:

* • Histologically confirmed mantle cell lymphoma with cyclin D1 (BCL1) expression by immunohistochemical stains and/or t(11;14) by cytogenetics or fluorescence in situ hybridization (FISH) as confirmed by the enrolling center * Any stage allowed (stage I-IV) * Presence of measurable disease, defined as \>= 1 nodal lesion that is \> 1.5 cm in longest diameter or \>= 1 extranodal lesion that is \> 1 cm in longest diameter * Steroids for management of mantle cell lymphoma are allowed up to a dose of prednisone 100mg/day (or equivalent) for up to 7 days * No prior systemic treatment for mantle cell lymphoma * No prior radiation treatment for stage I MCL * No prior exposure to a BTK inhibitor or anti-CD20 monoclonal antibody * No prior stem cell transplant * Age \>= 70 years OR age \>= 60 to \< 70 years with comorbidities precluding autologous stem cell transplantation (autoSCT) including at least one of the following: a) cardiac ejection fraction (EF) \< 45%, b) diffusing capacity for carbon monoxide \< 60% predicted; c) creatinine clearance \< 70 but \> 30ml/minute (min); d) Eastern Cooperative Oncology Group (ECOG) performance status of 2, which poses an unacceptable risk of toxicity for high-dose therapy and stem cell transplantation; or e) Cumulative Illness Rating Scales (CIRS) total score \> 6 * ECOG Performance Status 0-2 * Absolute neutrophil count (ANC) \>= 750/mm\^3 (without growth factor support within 7 days) * Platelet count \>= 75,000/mm\^3 (or \>= 50,000/mm\^3 for patients with bone marrow involvement of lymphoma) without growth factor support or transfusion within 7 days * Creatinine clearance \>= 30 mL/ min determined by either: a) Estimation using the Cockcroft-Gault equation or b) Measurement by nuclear medicine scan or 24 hour urine collection * Total bilirubin =\< 1.5 x upper limit of normal (ULN) (unless documented Gilbert's syndrome) * Aspartate transferase (AST) / alanine transaminase (ALT) =\< 3 x ULN * Patients should not be considered candidates for stem cell transplant or must have declined a stem cell transplant strategy * No clinically significant cardiovascular disease including the following * Unstable angina within 3 months before registration * New York Heart Association class III or IV congestive heart failure * History of clinically significant arrhythmias (eg, sustained ventricular tachycardia, ventricular fibrillation, torsades de pointes) * QT correction formula (QTcF) \> 480 msecs based on Fredericia's formula * History of Mobitz II second-degree or third-degree heart block without a permanent pacemaker in place * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial * No active Hepatitis B or Hepatitis C infection. Patients with prior hepatitis B virus (HBV) exposure (positive HBV core antibody and/or surface antigen) are eligible if they have no detectable viral load, and are taking appropriate prophylactic antiviral therapy to prevent reactivation. Patients with history of hepatitis C virus (HCV) are eligible if they have an undetectable HCV viral load * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * No history of severe bleeding disorder such as hemophilia A, hemophilia B, von Willebrand disease, or history of spontaneous bleeding requiring blood transfusion or other medical intervention * No history of stroke or intracranial hemorrhage within 6 months prior to registration * No disease significantly affecting gastrointestinal function such as malabsorption syndrome, resection of the stomach or small bowel, bariatric surgery procedures, symptomatic inflammatory bowel disease, or partial or complete bowel obstruction. Patient must be able to swallow pills * Potential trial participants should have recovered from major surgery * No vaccination with a live vaccine within 35 days prior to registration * No hypersensitivity to zanubrutinib or rituximab or any of the other ingredients of the study drugs * Chronic concomitant treatment with strong inhibitors of CYP3A4 is not allowed on this study. Patients on strong CYP3A4 inhibitors must discontinue the drug for 14 days prior to registration on the study. * Chronic concomitant treatment with strong CYP3A4 inducers is not allowed. Patients must discontinue the drug 14 days prior to the start of study treatment * Avoid use of moderate CYP3A4 inhibitors, PGP inhibitors, and moderate CYP3A4 inducers * Archival tissue must be available for submission in all patients for histopathology review, though participation in correlative substudies is optional

Interventions: DRUG: Zanubrutinib, BIOLOGICAL: Rituximab, OTHER: Patient Observation, PROCEDURE: Bone Marrow Biopsy, OTHER: Fludeoxyglucose F-18, PROCEDURE: Positron Emission Tomography, PROCEDURE: Computed Tomography, PROCEDURE: Magnetic Resonance Imaging, PROCEDURE: Esophagogastroduodenoscopy, PROCEDURE: Colonoscopy, PROCEDURE: Biospecimen Collection, OTHER: Questionnaire Administration

Conditions: Mantle Cell Lymphoma

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Location	Contacts
Abbott-Northwestern Hospital Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Alliance for Clinical Trials in Oncology Boston, Massachusetts	Anne W. Beaven - (beaven@med.unc.edu)
Augusta University Medical Center Augusta, Georgia	Site Public Contact - (ga_cares@augusta.edu)
Benefis Sletten Cancer Institute Great Falls, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Billings Clinic Cancer Center Billings, Montana	Site Public Contact - (research@billingsclinic.org)
Bozeman Health Deaconess Hospital Bozeman, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Broadlawns Medical Center Des Moines, Iowa
Cancer Care Center of O'Fallon O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Centers of Southwest Oklahoma Research Lawton, Oklahoma
Cancer Hematology Centers - Flint Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Carle Cancer Center Urbana, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Effingham Effingham, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois	Site Public Contact - (Research@carle.com)
Carle at The Riverfront Danville, Illinois	Site Public Contact - (Research@Carle.com)
Cedars Sinai Medical Center Los Angeles, California
Chelsea Hospital Chelsea, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
City of Hope Comprehensive Cancer Center Duarte, California
City of Hope at Irvine Lennar Irvine, California
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud, Minnesota	Site Public Contact - (coborncancercenter@centracare.com)
Community Hospital of Anaconda Anaconda, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Community Medical Center Missoula, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Corewell Health Beaumont Troy Hospital Troy, Michigan
Corewell Health Farmington Hills Hospital Farmington Hills, Michigan
Corewell Health William Beaumont University Hospital Royal Oak, Michigan
CoxHealth South Hospital Springfield, Missouri
Crossroads Cancer Center Effingham, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Dartmouth Cancer Center - North Saint Johnsbury, Vermont	Site Public Contact - (cancer.research.nurse@hitchcock.org)
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon, New Hampshire	Site Public Contact - (cancer.research.nurse@dartmouth.edu)
Decatur Memorial Hospital Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Duke University Medical Center Durham, North Carolina
Duluth Clinic Ashland Ashland, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Emory Johns Creek Hospital Johns Creek, Georgia	Site Public Contact - (m.lisa.hwang@emory.edu)
Emory Saint Joseph's Hospital Atlanta, Georgia
Emory University Hospital Midtown Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute Atlanta, Georgia
Essentia Health - Deer River Clinic Deer River, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Hibbing Clinic Hibbing, Minnesota
Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Sandstone Sandstone, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Virginia Clinic Virginia, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Freeman Physician Group of Pittsburg Pittsburg, Kansas	Site Public Contact - (BNMathew@freemanhealth.com)
Froedtert and MCW Moorland Reserve Health Center New Berlin, Wisconsin
Genesee Hematology Oncology PC Flint, Michigan
Genesys Hurley Cancer Institute Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Grady Health System Atlanta, Georgia
Gundersen Lutheran Medical Center La Crosse, Wisconsin	Site Public Contact - (cancerctr@gundersenhealth.org)
HaysMed Hays, Kansas
Helen F Graham Cancer Center Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Hematology Oncology Associates of CNY at Camillus Camillus, New York
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse, New York
Hennepin County Medical Center Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Henry Ford Saint John Hospital - Macomb Medical Macomb, Michigan	Site Public Contact - (kforman1@hfhs.org)
Huntsman Cancer Institute/University of Utah Salt Lake City, Utah	Site Public Contact - (cancerinfo@hci.utah.edu)
Hurley Medical Center Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Huron Gastroenterology PC Ypsilanti, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Illinois CancerCare - Washington Washington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Bloomington Bloomington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Canton Canton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Carthage Carthage, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Dixon Dixon, Illinois
Illinois CancerCare-Eureka Eureka, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Galesburg Galesburg, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Macomb Macomb, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Pekin Pekin, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peoria Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peru Peru, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Princeton Princeton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Iowa Methodist Medical Center Des Moines, Iowa
Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York	Site Public Contact - (CancerTrials@nyulangone.org)
Lawrence Memorial Hospital Lawrence, Kansas	Site Public Contact - (Stephanie.Norris@LMH.ORG)
Logan Health Medical Center Kalispell, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Marshfield Medical Center - Minocqua Minocqua, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Weston Weston, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Marshfield Marshfield, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Mary Greeley Medical Center Ames, Iowa
McFarland Clinic - Ames Ames, Iowa	Site Public Contact - (ksoder@mcfarlandclinic.com)
McFarland Clinic - Boone Boone, Iowa
McFarland Clinic - Jefferson Jefferson, Iowa
McFarland Clinic - Marshalltown Marshalltown, Iowa
McFarland Clinic - Trinity Cancer Center Fort Dodge, Iowa
McLaren Cancer Institute-Bay City Bay City, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Central Michigan Mount Pleasant, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Clarkston Clarkston, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Flint Flint, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Lapeer Region Lapeer, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Northern Michigan Petoskey, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
Medical College of Wisconsin Milwaukee, Wisconsin
Medical Oncology Hematology Consultants PA Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Medical University of South Carolina Charleston, South Carolina	Site Public Contact - (hcc-clinical-trials@musc.edu)
Memorial Hospital East Shiloh, Illinois	Site Public Contact - (dschwab@wustl.edu)
Mercy Hospital Cedar Rapids, Iowa	Site Public Contact - (mmcorc@healthpartners.com)
Mercy Hospital South St Louis, Missouri	Site Public Contact - (Danielle.Werle@mercy.net)
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Prisma Health Cancer Institute - Butternut Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
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ProHealth D N Greenwald Center Mukwonago, Wisconsin	Site Public Contact - (research.institute@phci.org)
ProHealth Oconomowoc Memorial Hospital Oconomowoc, Wisconsin
Providence Newberg Medical Center Newberg, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Portland Medical Center Portland, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Saint Vincent Medical Center Portland, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
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Regions Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Rhode Island Hospital Providence, Rhode Island
Roswell Park Cancer Institute Buffalo, New York	Site Public Contact - (askroswell@roswellpark.org)
Saint Alphonsus Cancer Care Center-Boise Boise, Idaho	Site Public Contact - (stephanie.couch@stjoeshealth.org)
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Saint Anthony Regional Hospital Carroll, Iowa	Site Public Contact - (sbenson@iora.org)
Saint Catherine Hospital Garden City, Kansas	Site Public Contact - (protocols@AllianceNCTN.org)
Saint Francis Medical Center Cape Girardeau, Missouri	Site Public Contact - (sfmc@sfmc.net)
Saint John's Hospital - Healtheast Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Saint Luke's Cancer Institute - Boise Boise, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Fruitland Fruitland, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Meridian Meridian, Idaho	Site Public Contact - (eslinget@slhs.org)
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Saint Luke's Hospital Chesterfield, Missouri
Saint Mary Medical Center Hobart, Indiana	Site Public Contact - (CancerResearch@COMHS.org)
Saint Mary's Oncology/Hematology Associates of West Branch West Branch, Michigan
Salina Regional Health Center Salina, Kansas	Site Public Contact - (mleepers@srhc.com)
Sanford Bismarck Medical Center Bismarck, North Dakota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford Broadway Medical Center Fargo, North Dakota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota	Site Public Contact - (OncologyClinicTrialsSF@sanfordhealth.org)
Sanford Joe Lueken Cancer Center Bemidji, Minnesota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
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The Community Hospital Munster, Indiana
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Tower Cancer Research Foundation Beverly Hills, California	Site Public Contact - (towercancerresearch@toweroncology.com)
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Health Education Approach to Lung Screening (HEALS)

Contact(s):

Massey IIT Research Operations - masseyepd@vcu.edu

Principal Investigator:

System ID: NCT06070870

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Interventions: BEHAVIORAL: Patient Navigation

Conditions: Lung Cancer

Keywords: Lung cancer, Screening

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Medical University of South Carolina Charleston, South Carolina	Ellen Gomez, MA - (gomezel@musc.edu)
University of North Carolina-Chapel Hill Carrboro, North Carolina	Christopher Lyu, MPA - (Christopher_Lyu@med.unc.edu)
Virginia Commonwealth University Richmond, Virginia	Massey CPC Team - (MasseyCPC@vcu.edu)

Oral Azacitidine in Transplant-Eligible Patients With Acute Myeloid Leukemia (AML) Suffering From Health-Inequality (REMAIN1)

Contact(s):

Massey IIT Research Operations - masseyepd@vcu.edu

Principal Investigator:

System ID: NCT06370000

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Inclusion Criteria:

* Patients must have histologically or cytologically confirmed non-Acute Promyelocytic (APL) FLT3 negative AML and have completed induction and consolidation as defined by the treating physician and must be in complete response (CR), Complete response with partial hematologic recovery (CRh), or Complete response with incomplete count recovery (CRi) at time of study enrollment * For patients in CR1, AML disease phenotype must be one that is considered for allo HCT in CR1 (intermediate or high risk by European Leukemia Net (ELN), MRD+ CR, slow clearance of MRD) or any AML phenotype (aside from FLT3+ and APL) in CR2 and beyond * Medically eligible for allogeneic hematopoietic cell transplant (allo HCT) as defined by either: treating physician discretion, transplant physician discretion, or hematopoietic cell transplantation-specific Comorbidity index (HCT-CI) index of 5 or less * Age ≥ 18 years * Enrollment must occur within 4 months of completion of therapy * A patient or staff identified health disparity in 1 of the 5 Centers for Disease Control (CDC) defined social determinants of health (SDOH). This may include financial difficulties, lack of caregiver support, difficulties with medical literacy, rurality, appropriate access to health care, lack of an appropriate allogeneic hematopoietic cell transplant (allo HCT) donor, substance abuse * Patient must have adequate organ function defined as: Creatinine clearance (by Cockroft-Gault formula) greater than or equal to 29 mL/min, total bilirubin and aspartate aminotransferase/ alanine transaminase (AST/ALT) ≤ to institutional 2x upper limit of normal (except Gilbert's syndrome, which may enroll if \< 2x patient's baseline total bilirubin) * Eastern Cooperative Oncology Group (ECOG) 0,1,2,3 * Ability to take oral medications * No history of malabsorption syndrome which, in the investigator's opinion, may inhibit absorption of oral medications * Women of childbearing potential must consent to effective contraception during study treatment and at least 6 months following the last dose. Women who are breastfeeding are also excluded * Male patients must consent to effective contraception during study and at least 3 months after last dose * Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria A patient who meets any of the following exclusion criteria is ineligible to participate in the study. * FMS-like tyrosine kinase 3 (FLT3 ITD) or tyrosine kinase domain (TKD) mutation * Uncontrolled central nervous system (CNS) involvement * History of hypersensitivity or allergic reaction to azacitidine or its components * Stem cell transplant within previous 3 months prior to initiation of study therapy * Uncontrolled intercurrent illness or infection * History of prior therapy with oral azacitidine * Female patients who are pregnant or intend to donate eggs during the study or for 6 months after receiving their last dose of study drug * Male patients who intend to donate sperm during the course of this study or for 3 months after last dose * Other malignancy for which the patient is currently receiving therapy (except excisable skin cancer) * Medical, psychological, or social condition that, in the opinion of the investigator, may increase the participant's risk or limit the participant's adherence with study requirements

Interventions: DRUG: Oral Azacitidine

Conditions: Acute Myeloid Leukemia

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Virginia Commonwealth University Richmond, Virginia	Massey CTO Heme Team - (MasseyHemMlg@vcu.edu)

Selinexor With Combination With Induction/Consolidation Therapy in Acute Myeloid Leukemia Patients

Contact(s):

Study Coordinator - dfunes@wakehealth.edu

Principal Investigator:

System ID: NCT02835222

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Inclusion Criteria:

* Patients must have histologically or cytologically documented newly diagnosed de novo Acute Myeloid Leukemia (non-APL) that has not yet been treated. Hydrea,cytarabine and ATRA previous treatments are acceptable. * Patients with core binding factor acute myeloid leukemia (AML) (ie AML with t(8;21) or t(16;16) or i16) are not eligible. * Patients must not have a secondary AML (defined as a history of prior radiation therapy or systemic chemotherapy, CMML or MDS not treated with a hypomethylating agent) however history of previous MDS treated with a hypomethylating agent IS allowed. * Patients with de novo AML must not have partial or total monosomy 5 or 7 or i(17q) or t(17p). Negative FISH studies are sufficient for enrollment (i.e. FISH for -5, -7, +8, inv(16), t(8;21) and 17p). * Patients must not have mutated FLT3 (either ITD OR TKD mutations). * Hydroxyurea, leukapheresis or cytarabine may be used to control leukocytosis, provided that it is without Grade \>2 non-hematologic toxicity, and can be taken until start of therapy. * Age \>18 years. * ECOG performance status of ≤ 2 and fit for induction therapy in the opinion of the treating physician. * Laboratory values ≤2 weeks must be: * AST(SGOT)/ALT(SGPT)≤ 2.5 X institutional upper limit of normal * Bilirubin ≤ 2 X ULN (3X if known history of Gilbert'syndrome) * Creatinine clearance (CrCl) must be \> 20 mL/min * Baseline left ventricular ejection fraction of at least 40% by MUGA or ECHO. * Female patients of childbearing potential must agree to use 2 methods of contraception (including 1 highly effective and 1 effective method of contraception) and have a negative serum pregnancy test at Screening. Male patients must use an effective barrier method of contraception if sexually active with a female of childbearing potential. For both male and female patients, effective methods of contraception must be used throughout the study and for 3 months following the last dose of study treatment. * Ability to understand and the willingness to sign an IRB-approved informed consent document.

Exclusion Criteria:

* Patients who have received any therapy other than hydroxyurea, cytarabine or ATRA with the purpose of treating their AML or patients with core binding factor AML or Acute Promyelocytic Leukemia are not eligible. * Patients with a secondary AML (defined as a history of prior radiation therapy or systemic chemotherapy, CMML or MDS not treated with a hypomethylating agent) however history of previous MDS treated with a hypomethylating agent IS allowed. * Patients having received prior radiotherapy, treatment with cytotoxic agents, treatment with biologic agents or any anti-cancer therapy for a non-AML malignancy within the 4 weeks prior to treatment with selinexor, or those who have not fully recovered from the acute, non-hematological, non-infectious toxicities of any prior treatment with cytotoxic drugs, radiotherapy or other anti-cancer modalities (returned to baseline status as noted before most recent treatment). * Patients with another active malignancy that requires treatment excluding non-melanoma skin cancers. * Patients that have received a chemotherapy regimen with stem cell support in the previous 6 months. * Patients with known central nervous system involvement should be excluded from this clinical trial because the penetration of selinexor into the CNS is not currently known. * History of allergic reactions attributed to compounds of similar chemical or biologic composition to selinexor. * Uncontrolled concurrent illness including, but not limited to symptomatic congestive heart failure, unstable angina pectoris, or cardiac arrhythmia * Psychiatric illness/social situations that would limit compliance with study requirements. * Patients with known HIV infection or hepatitis (Note: Patients with known HIV infection are excluded because patients with an immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy. * Pregnant women are excluded from this study because of the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother, breastfeeding should be discontinued. * Patients unable to swallow tablets, patients with malabsorption syndrome, or any other GI disease or GI dysfunction that could interfere with absorption of study treatment * Prior exposure to a SINE compound

Interventions: DRUG: Cytarabine, DRUG: Daunorubicin Hydrochloride, DRUG: Selinexor

Conditions: Untreated Adult Acute Myeloid Leukemia

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Comprehensive Cancer Center of Wake Forest University Winston-Salem, North Carolina	Study Coordinator - (dfunes@wakehealth.edu)
Virginia Commonwealth University Massey Cancer Center Richmond, Virginia

Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer (GLORIOSA)

Contact(s):

ABBVIE CALL CENTER - abbvieclinicaltrials@abbvie.com

Principal Investigator:

System ID: NCT05445778

Show full eligibility criteria

Interventions: DRUG: Mirvetuximab soravtansine plus Bevacizumab, DRUG: Bevacizumab

Conditions: Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer

Keywords: Platinum-sensitive, Folate-receptor alpha expression, Antibody-drug conjugate, Cancer, Ovarian Neoplasma, Recurrent Platinum-Sensitive, High-Grade Ovarian, ADC, Adult

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AUSL Piacenza-Ospedale Guglielmo da Saliceto /ID# 269468 Piacenza,
AUSL di Reggio Emilia - Arcispedale Santa Maria Nuova /ID# 269471 Reggio Emilia,
AZ Sint-Lucas /ID# 269366 Ghent, Oost-Vlaanderen
AZ-Delta /ID# 269091 Roeselare, West-Vlaanderen
Affiliated Cancer Hospital of Guangxi Medical University Nanning, Guangxi
Aichi Cancer Center /ID# 274332 Nagoya, Aichi-ken
Alessandro Manzoni Hospital /ID# 269467 Lecco,
Allegheny Health Network West Penn Hospital /ID# 269551 Pittsburgh, Pennsylvania
Arthur J. E. Child Comprehensive Cancer Centre /ID# 269388 Calgary, Alberta
Asan Medical Center /ID# 269480 Seoul, Seoul Teugbyeolsi
Asplundh Cancer Pavilion /ID# 269574 Willow Grove, Pennsylvania
Azienda Ospedaliero Universitaria Careggi /ID# 269465 Florence, Firenze
Azienda Ospedaliero Universitaria Di Parma /ID# 269466 Parma,
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 269470 Rome, Roma
Azienda USL Toscana Nord Ovest - Ospedale San Luca /ID# 269095 Lucca,
BC Cancer - Vancouver /ID# 269394 Vancouver, British Columbia
Ballarat Base Hospital /ID# 269364 Ballarat, Victoria
Baptist Health Lexington /ID# 269568 Lexington, Kentucky
Baptist Md Anderson Cancer Center - Jacksonville - Palm Avenue /ID# 269560 Jacksonville, Florida
Baskent Universitesi Adana Uyg. Ve Arast. Merkezi Yuregir Baskent Hastanesi /ID# 270174 Adana,
Baystate Medical Center /ID# 269544 Springfield, Massachusetts
Başkent Üniversitesi Ankara Hastanesi /ID# 269524 Ankara,
Bc Cancer Agency - Fraser Valley Centre /ID# 269398 Surrey, British Columbia
Beaumont Hospital /ID# 269452 Dublin,
Beijing Cancer Hospital Beijing,
Beneficência Portuguesa de São Paulo /ID# 269092 São Paulo, São Paulo
Bon Secours Cork Hospital /ID# 269449 Cork,
Broward General Medical Center /ID# 269577 Fort Lauderdale, Florida
CHA Bundang Medical Center /ID# 269489 Seongnam, Gyeonggido
CHU Brest /ID# 269422 Brest, Finistere
CHUM - Centre hospitalier de l'Universite de Montréal /ID# 269387 Montreal, Quebec
CIUSSS Estrie - Sherbrooke University Hospital Center /ID# 269393 Sherbrooke, Quebec
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 269405 Madrid,
Cabrini Hospital Malvern /ID# 269359 Malvern, Victoria
Cancer Hospital Affliated to Xinjiang Medical University Ürümqi, Xinjiang
Capital Medical University (Cmu) Beijing, Beijing Municipality
Cardinal Santos Medical Center /ID# 269100 San Juan City, National Capital Region
Casa di Cura San Pio X /ID# 277973 Milan, Milano
Catarina Pesquisa Clinica /ID# 269379 Itajaí, Santa Catarina
Centre Leon Berard /ID# 269418 Lyon, Rhone
Cheltenham General Hospital /ID# 269427 Cheltenham, Gloucestershire
Chiba University Hospital /ID# 274371 Chiba, Chiba
Chu Dijon /Id# 269417 Dijon, Bourgogne-Franche-Comté
City of Hope - Orange County Lennar Foundation Cancer Center /ID# 269573 Irvine, California
Clinica Universidad de Navarra - Pamplona /ID# 269410 Pamplona, Navarre
Cliniques Universitaires UCL Saint-Luc /ID# 269368 Brussels, Brussels Capital
Compass Oncology - Rose Quarter /ID# 270131 Portland, Oregon
Complejo Hospitalario Universitario A Coruña /ID# 269414 A Coruña, A Coruna
Complex Oncology Center - Shumen /ID# 269372 Shumen,
Comprehensive Cancer Center /ID# 269373 Vratsa,
Corewell Health /ID# 269562 Grand Rapids, Michigan
Cork University Hospital /ID# 269451 Cork,
Cross Cancer Institute /ID# 269392 Edmonton, Alberta
Dartmouth-Hitchcock Medical Center /ID# 269576 Lebanon, New Hampshire
Duke Cancer Institute /ID# 269557 Durham, North Carolina
East Avenue Medical Center /ID# 269099 Quezon City, National Capital Region
Edith Wolfson Medical Center /ID# 269461 Holon, Central District
Ente Ospedaliero Ospedali Galliera /ID# 269472 Genoa, Genova
Epworth Hospital /ID# 269363 Richmond, Victoria
Fakultní Nemocnice Brno - Jihlavská /ID# 269401 Brno, Brno-mesto
Fakultní nemocnice Ostrava /ID# 269403 Ostrava, Ostrava-mesto
Fondazione IRCCS Policlinico San Matteo /ID# 269463 Pavia,
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 269096 Rome, Roma
Fudan University Cancer Hospital Shanghai, Shanghai Municipality
Fujian Province Cancer Hospital Fuzhou, Fujian
GBMC Cancer Center /ID# 269561 Towson, Maryland
Gangnam Severance Hospital /ID# 269484 Seoul, Seoul Teugbyeolsi
General Hospital of Athens Alexandra /ID# 269444 Athens,
General University Hospital in Prague, Charles University /ID# 269402 Prague, Ceske Budejovice
Gold Coast University Hospital /ID# 269365 Southport, Queensland
Grand Hôpital De Charleroi - Notre Dame /ID# 269367 Charleroi, Hainaut
Guy's Hospital /ID# 269426 London, Greater London
Hacettepe University Faculty of Medicine /ID# 269521 Ankara,
Hadassah Medical Center-Hebrew University /ID# 269458 Jerusalem,
Harbin Medical University Cancer Hospital Harbin,
Henan Cancer Hospital Zhengzhou,
Hokkaido University Hospital /ID# 274331 Sapporo, Hokkaido
Holy Name Medical Center /ID# 269543 Teaneck, New Jersey
Honorhealth Virginia G. Piper Cancer Care Network - Biltmore /ID# 269987 Phoenix, Arizona
Hospital Clinic de Barcelona /ID# 269408 Barcelona,
Hospital Clínico Universitario de Valencia /ID# 269412 Valencia,
Hospital Italiano de Buenos Aires /ID# 269356 Buenos Aires,
Hospital Italiano de Córdoba (Sociedad de Beneficencia Hospital Italiano) /ID# 269090 Córdoba,
Hospital Nove De Julho /ID# 269375 São Paulo, São Paulo
Hospital Santa Izabel /ID# 269384 Salvador, Estado de Bahia
Hospital Universitari De Girona Doctor Josep Trueta /ID# 269411 Girona,
Hospital Universitari Vall d'Hebron /ID# 269406 Barcelona,
Hospital Universitario La Paz /ID# 269407 Madrid,
Hospital Universitario Reina Sofia /ID# 270296 Córdoba, Cordoba
Hospital Universitario Virgen de la Victoria /ID# 269413 Málaga, Malaga
Hubei Cancer Hospital Wuhan,
Hunan Province Cancer Hospital Changsha, Hunan
Hygeia Hospital /ID# 270132 Athens,
Hyogo Cancer Center /ID# 274323 Akashi-shi, Hyōgo
Hôpital La Timone /ID# 269421 Marseille, Bouches-du-Rhone
IASO Hospital /ID# 269443 Marousi,
IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 269476 Bologna,
IRCCS Istituto Clinico Humanitas /ID# 269473 Rozzano, Lombardy
IRCCS Ospedale San Raffaele /ID# 269475 Milan, Milano
Icahn School of Medicine at Mount Sinai /ID# 269529 New York, New York
Imelda Ziekenhuis /ID# 269369 Bonheiden, Antwerpen
Indiana University Melvin and Bren Simon Comprehensive Cancer Center /ID# 269110 Indianapolis, Indiana
Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 269409 L'Hospitalet de Llobregat, Barcelona
Institut Curie /ID# 269420 Paris, Île-de-France Region
Institut de cancérologie Strasbourg Europe (ICANS) /ID# 269419 Strasbourg, Bas-Rhin
Isis Centro Especializado De Luce /ID# 269353 Santa Fe,
Istituto Nazionale Dei Tumori /ID# 269477 Milan, Milano
Istituto Nazionale Tumori Irccs Fondazione G. Pascale /ID# 269097 Naples, Napoli
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST - IRCCS /ID# 269474 Meldola, Reggio Emilia
Iwate Medical University Hospital - Yahabacho /ID# 274635 Yahaba, Iwate
Jagiellonskie Centrum Innowacji Sp. z o.o. /ID# 269497 Krakow, Lesser Poland Voivodeship
Jichi Medical University Hospital /ID# 274634 Shimotsuke-shi, Tochigi
John Muir Health - Walnut Creek Medical Center /ID# 269575 Walnut Creek, California
John Theurer Cancer Center /ID# 269109 Hackensack, New Jersey
Johns Hopkins Hospital /ID# 269579 Baltimore, Maryland
Juravinski Cancer Centre - Hamilton Health Sciences /ID# 269396 Hamilton, Ontario
Kagoshima University Hospital /ID# 276081 Kagoshima, Kagoshima-ken
Kaiser Permanente - San Diego Medical Center /ID# 269540 San Diego, California
Kaiser Permanente - San Marcos Medical Offices /ID# 269542 San Marcos, California
Kaiser Permanente Zion Medical Center /ID# 269537 San Diego, California
Kaplan Medical Center /ID# 269457 Rehovot, Central District
Keimyung University Dongsan Hospital /ID# 269488 Daegu, Gyeongsangbuk-do
Keio University Hospital /ID# 276159 Shinjuku-ku, Tokyo
Kettering Medical Center /ID# 269585 Kettering, Ohio
Kingston General Hospital /ID# 269397 Kingston, Ontario
Klinikum Dortmund Klinikzentrum Mitte /ID# 269441 Dortmund, North Rhine-Westphalia
Klinikum Esslingen /ID# 269435 Esslingen am Neckar, Baden-Wurttemberg
Korea University Anam Hospital /ID# 269486 Seoul, Seoul Teugbyeolsi
Korea University Guro Hospital /ID# 269490 Seoul, Seoul Teugbyeolsi
Krankenhaus Jerusalem /ID# 269430 Hamburg,
Kurume University Hospital /ID# 274337 Kurume-shi, Fukuoka
Liaoning Cancer Hospital & Institute Shenyang, Liaoning
Linyi Cancer Hospital Linyi,
Louisiana State University Health Sciences Center - New Orleans /ID# 269559 New Orleans, Louisiana
Maine Medical Center - Scarborough Campus /ID# 269555 Scarborough, Maine
Mazowiecki Szpital Wojewodzki im. Sw. Jana Pawla II w Siedlcach Sp. z o.o. /ID# 269500 Siedlce, Masovian Voivodeship
McGill University Health Centre - Glen Site /ID# 269389 Montreal, Quebec
Meir Medical Center /ID# 269454 Kfar Saba, Central District
Minnesota Oncology - Coon Rapids Clinic /ID# 269550 Coon Rapids, Minnesota
Monash Health - Monash Medical Centre /ID# 269360 Clayton, Victoria
Moores Cancer Center at UC San Diego /ID# 269564 La Jolla, California
Mount Sinai Medical Center /ID# 269582 Miami, Florida
Mount Vernon Hospital /ID# 269423 Northwood, Greater London
NYU Laura and Isaac Perlmutter Cancer Center /ID# 269556 New York, New York
National Cancer Center /ID# 269481 Goyang-si, Gyeonggido
National Cancer Center Hospital /ID# 274321 Chuo-Ku, Tokyo
National Hospital Organization Shikoku Cancer Center /ID# 276078 Matsuyama, Ehime
Nebraska Methodist Hospital /ID# 269580 Omaha, Nebraska
Nemocnice Novy Jicin /ID# 269400 Nový Jičín, Novy Jicin
New Hospital of Prato - S. Stefano /ID# 269464 Prato,
New York Oncology Hematology - Albany Cancer Center /ID# 269565 Albany, New York
Niigata University Medical & Dental Hospital /ID# 274329 Niigata, Niigata
Northside Hospital /ID# 269660 Atlanta, Georgia
Northwell Health Center for Advanced Medicine /ID# 269108 Lake Success, New York
Ochsner Medical Center - Jefferson Highway /ID# 269530 New Orleans, Louisiana
Okayama University Hospital /ID# 274324 Okayama, Okayama-ken
Oklahoma Cancer Specialists and Research Institute /ID# 269527 Tulsa, Oklahoma
Olive View-Ucla Medical Center /ID# 269584 Sylmar, California
Onkologische Schwerpunktpraxis Bielefeld /ID# 269440 Bielefeld, North Rhine-Westphalia
Oregon Health and Science University /ID# 269581 Portland, Oregon
Osaka Medical And Pharmaceutical University Hospital /ID# 276079 Takatsuki, Osaka
Ospedale Cannizzaro /ID# 269478 Catania,
Ospedale San Martino /ID# 269469 Genoa, Genova
Ospedale di Mirano - Azienda ULSS 3 /ID# 269462 Mirano, Venezia
Ou Health - Stephenson Cancer Center /ID# 269525 Oklahoma City, Oklahoma
Peter MacCallum Cancer Centre /ID# 269361 Melbourne, Victoria
Princess Margaret Cancer Centre /ID# 269390 Toronto, Ontario
Qilu Hospital of Shandong University Jinan,
Rabin Medical Center /ID# 269456 Petah Tikva, Central District
Regional Cancer Center /ID# 269558 Fort Myers, Florida
Rush University Medical Center /ID# 269583 Chicago, Illinois
Saitama Medical University International Medical Center /ID# 274953 Hidaka, Saitama
Samsung Medical Center /ID# 269487 Seoul, Seoul Teugbyeolsi
Sanatorio De La Mujer /ID# 269352 Rosario, Santa Fe Province
Sanford Cancer Center /ID# 269535 Sioux Falls, South Dakota
Sapporo Medical University Hospital /ID# 274330 Sapporo, Hokkaido
Sarasota Memorial Hospital /ID# 269526 Sarasota, Florida
Seoul National University Bundang Hospital /ID# 269482 Seongnam-si, Gyeonggido
Seoul National University Hospital /ID# 269479 Seoul, Seoul Teugbyeolsi
Shaare Zedek Medical Center /ID# 269459 Jerusalem,
Shandong Cancer Hospital Jinan,
Shanxi Cancer Hospital Taiyuan, Shanxi
Shizuoka Cancer Center /ID# 274325 Sunto-gun, Shizuoka
Sinai Hospital Of Baltimore /ID# 269567 Manchester, Maryland
Singleton Hospital /ID# 269424 Swansea,
Sligo General Hospital /ID# 269448 Sligo,
St James Hospital /ID# 269446 Dublin, Dublin
St. John Of God Subiaco Hospital /ID# 269358 Subiaco, Western Australia
St. Luke's Hospital S.A. /ID# 269445 Panórama, Thessaloniki
St. Vincent Indianapolis Hospital /ID# 269107 Indianapolis, Indiana
Stanford Women'S Cancer Center /ID# 269552 Palo Alto, California
Sun Yat-Sen University (Sysu) - Sun Yat-Sen Memorial Hospital Guangzhou, Guangdong
Swedish Cancer Institute /ID# 269538 Seattle, Washington
Szpitale Pomorskie Sp. z o.o. /ID# 269495 Gdynia, Pomeranian Voivodeship
Tel Aviv Sourasky Medical Center /ID# 269455 Tel Aviv, Tel Aviv
Texas Oncology - Austin Central /ID# 269531 Austin, Texas
Texas Oncology - Bedford /ID# 269571 Bedford, Texas
Texas Oncology - Fort Worth Cancer Center /ID# 269532 Fort Worth, Texas
Texas Oncology - Methodist Dallas Cancer Center /ID# 269554 Dallas, Texas
Texas Oncology - San Antonio Medical Center - Research Drive /ID# 269549 San Antonio, Texas
The Affiliated Women's Hospital Of Zhejiang University Hangzhou, Zhejiang
The Cancer Institute Hospital Of JFCR /ID# 274326 Koto-ku, Tokyo
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 269485 Seoul, Seoul Teugbyeolsi
The Center Of Hope /ID# 269528 Reno, Nevada
The Chaim Sheba Medical Center /ID# 269094 Ramat Gan, Tel Aviv
The Christie /ID# 269428 Manchester,
The First Affiliated Hospital of Xi'An Jiaotong University Xi'an,
The First Affiliated Hospital, Sun-Yat Sen University Guangzhou, Guangdong
The First Bethune Hospital of Jilin University Changchun,
The Jikei University Kashiwa Hospital /ID# 274334 Kashiwa, Chiba
The Jikei University School of Medicine /ID# 276160 Tokyo,
The Lady Davis Carmel Medical Center /ID# 269453 Haifa,
The Medical City /ID# 269493 Pasig, National Capital Region
The Ohio State University Comprehensive Cancer Center /ID# 269105 Columbus, Ohio
The Ottawa Hospital - General Campus /ID# 269391 Ottawa, Ontario
The Royal Marsden - Chelsea /ID# 269102 London, Greater London
The Royal Marsden - Sutton /ID# 269103 Sutton, Surrey
The Second Affiliated Hospital of Zhengzhou University Zhengzhou, Henan
The University of Kansas Cancer Center - Westwood /ID# 269106 Westwood, Kansas
The Valley Hospital /ID# 269548 Paramus, New Jersey
The first affiliated hospital of bengbu medical college Bengbu, Anhui
Tianjin Cancer Hospital Tianjin,
Tohoku University Hospital /ID# 274327 Sendai, Miyagi
Tokai University Hospital /ID# 274336 Isehara, Kanagawa
Tufts Medical Center /ID# 269547 Boston, Massachusetts
UCL Namur University Hospital, Site Sainte-Elisabeth /ID# 269371 Namur,
US Oncology Research Investigational Products Center /ID# 278746 Irving, Texas
Universitaetsklinikum Bonn /ID# 269434 Bonn, North Rhine-Westphalia
Universitaetsklinikum Carl Gustav Carus Dresden /ID# 269433 Dresden, Saxony
Universitaetsklinikum Erlangen /ID# 269439 Erlangen, Bavaria
Universitaetsklinikum Hamburg-Eppendorf /ID# 269429 Hamburg,
Universitaetsklinikum Heidelberg /ID# 269438 Heidelberg, Baden-Wurttemberg
Universitaetsmedizin Mainz /ID# 269442 Mainz, Rhineland-Palatinate
Universitair Ziekenhuis Leuven /ID# 269370 Leuven, Vlaams-Brabant
Universite de Montreal - Hopital Maisonneuve-Rosemont /ID# 269395 Montreal, Quebec
University Hospital Galway /ID# 269447 Galway,
University Hospital Southampton /ID# 269425 Southampton, Hampshire
University Of California Irvine Medical Center /ID# 269572 Orange, California
University Of Pittsburgh Medical Center Magee - Womens Hospital /ID# 269659 Pittsburgh, Pennsylvania
University of Chicago Medical Center /ID# 269546 Chicago, Illinois
University of Cincinnati /ID# 269578 Cincinnati, Ohio
University of Iowa /ID# 269566 Iowa City, Iowa
University of Kentucky Chandler Medical Center /ID# 269536 Lexington, Kentucky
University of North Carolina at Chapel Hill /ID# 269563 Chapel Hill, North Carolina
University of Virginia Health System /ID# 269545 Charlottesville, Virginia
Universitätsklinikum Gießen /ID# 269432 Giessen,
Usa Mitchell Cancer Institute /ID# 269661 Mobile, Alabama
Vcu Health Adult Outpatient Pavillion /ID# 269570 Richmond, Virginia
Virginia Oncology Associates - Norfolk (Lake Wright) /ID# 269533 Norfolk, Virginia
Waterford Regional Hospital /ID# 269450 Waterford,
West Cancer Center and Research Institute - Germantown /ID# 269569 Germantown, Tennessee
West China Second University Hospital, Sichuan University Chengdu, Sichuan
Westmead Hospital /ID# 269362 Westmead, New South Wales
Wielkopolskie Centrum Onkologii /ID# 269494 Poznan, Greater Poland Voivodeship
Willamette Valley Cancer Institute and Research Center /ID# 269988 Eugene, Oregon
Women'S Cancer Care Associates /ID# 269553 Albany, New York
Yonsei University Health System Severance Hospital /ID# 269483 Seoul, Seoul Teugbyeolsi
Yunnan Province Cancer Hospital Kunming, Yunnan
ZIV Medical Center /ID# 269460 Safed,
Zhejiang Cancer Hospital Hangzhou,

A Phase 1 Clinical Study of NXP800 in Subjects with Advanced Cancers and Expansion in Subjects with Ovarian Cancer

Contact(s):

Diane Marsolini - dmarsolini@nuvectis.com

Principal Investigator:

System ID: NCT05226507

Show full eligibility criteria

Part A

Inclusion Criteria:

* Provide written informed consent. * 18 years old or older. * Life expectancy of at least 12 weeks. * Histologically- or cytologically-confirmed, advanced, metastatic, and/or progressive solid tumors for whom there is no authorized or effective therapy available, or for whom such therapies are considered inappropriate by the Investigator (in Part B, subjects with specific cancer types will be enrolled; Specific criteria will be introduced in a protocol amendment). * Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1. * Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2. Part A

Exclusion Criteria:

* Radiotherapy (except for palliative reasons), endocrine therapy, chemotherapy, or investigational agent within 28 days, (42 days for nitrosoureas, mitomycin-C) of first dose of NXP800. Subjects can continue to receive bisphosphonates due to metastatic bone disease or GnRH agonists if they have prostate cancer. * Ongoing toxic manifestations of previous treatments \> Grade 2. * Subjects with treated brain metastases are eligible if there is no evidence of progression for at least 28 days after central nervous system (CNS) directed treatment, as ascertained by clinical examination and brain imaging (magnetic resonance imaging \[MRI\] or computed tomography \[CT\] scan) during the Screening period. * Female subjects who can become pregnant (or are already pregnant or lactating). * Male subjects with partners of childbearing potential (unless they agree to take measures not to father children by using a barrier method of contraception (condom plus spermicide) or to sexual abstinence). Part B

Inclusion Criteria:

* Provide written informed consent. * 18 years old or older. * Subjects with the following ARID1a mutated, ovarian/fallopian tube/primary peritoneal cancer histologies (ARID1a mutation status determined by a DNA-based Next Generation Sequencing test): * Clear cell ovarian carcinoma (≥ 50% clear cell carcinoma with no serous differentiation) * Endometrioid ovarian carcinoma * Subjects must have disease progression within 6 months (182 days) from completion of platinum-based therapy (6 months should be calculated from the date of the last administered dose of platinum therapy to the date of radiographic imaging showing progression) * Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1. * Subjects with a BRCA mutation must have received prior treatment with a PARP inhibitor. * Subjects must have received at least 1 but not more than 3 prior systemic lines of anticancer therapy, including at least 1 line of therapy containing bevacizumab. * Adjuvant + neoadjuvant are considered one line of therapy * Maintenance therapy (i.e., bevacizumab, PARP inhibitors) will be considered as part of the preceeding line of therapy and are not counted independently. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Subjects must have a sufficient archival Formalin-Fixed Paraffin-Embedded (FFPE) tissue specimen, or be willing to consent to a fresh tissue biopsy during the study. Part B

Exclusion Criteria:

* Subjects with disease that did not respond to, or has progressed during or within 4 weeks of the last dose of first-line platinum containing chemotherapy. * Radiotherapy (except for palliative reasons), endocrine therapy, chemotherapy, or investigational agent within 28 days, (42 days for nitrosoureas, mitomycin-C) of first dose of NXP800. * Ongoing toxic manifestations of previous treatments \> Grade 2, with the exception of alopecia. * Subjects with treated brain metastases are eligible if there is no evidence of progression for at least 12 weeks while off corticosteroids after central nervous system (CNS) directed treatment, as ascertained by clinical examination and brain imaging (magnetic resonance imaging \[MRI\] or computed tomography \[CT\] scan) during the Screening period. * Female subjects who can become pregnant (or are already pregnant or lactating).

Interventions: DRUG: NXP800

Conditions: Advanced Solid Tumor, Ovarian Cancer, Ovarian Clear Cell Carcinoma, Ovarian Clear Cell Tumor, Ovarian Clear Cell Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Endometrioid Tumor, ARID1A Gene Mutation

Keywords: Solid Tumor, Carcinoma, Neoplasms, Adenocarcinoma, ARID1a

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Study Locations

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Location	Contacts
Addenbrookes Hospital Cambridge,
Florida Cancer Specialists Research East West Palm Beach, Florida	- (clinicaltrials@flcancer.com)
Florida Cancer Specialists Research North St. Petersburg, Florida	- (clinicaltrials@flcancer.com)
Florida Cancer Specialists South Fort Myers, Florida	- (clinicaltrials@flcancer.com)
Honor Health Scottsdale, Arizona
Mount Sinai Comprehensive Cancer Center Miami Beach, Florida
OU Health Stephenson Cancer Center Oklahoma City, Oklahoma
Oklahoma Cancer Specialists and Research Institute Tulsa, Oklahoma	Melissa Barnes - (melissa.barnes@oscri.org)
Oncology Associates of Oregon Eugene, Oregon
Royal Marsden Hospital Sutton,
Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey	Kassie DiOrio - (kassie.diorio@rutgers.edu)
Sidney Kimmel Cancer Center, Asplundh Cancer Pavilion Willow Grove, Pennsylvania	Ashley Douglas, RN, BSN, OCN - (ashley.douglas.2@jefferson.edu)
Texas Oncology Dallas, Texas
The Beatson West of Scotland Cancer Centre Glasgow,	Ruth Orr - (ruth.orr@ggc.scot.nhs.uk)
The Ohio State University Comprehensive Cancer Center Columbus, Ohio
The University of Texas MD Anderson Cancer Center Houston, Texas
UC San Diego Health - Moores Cancer Center San Diego, California	Alexandrea Cronin - (aocronin@health.ucsd.edu)
University of Colorado Cancer Center Aurora, Colorado
University of Iowa Iowa City, Iowa	David Bender, MD - (david-bender@uiowa.edu)
University of Virginia Health System Charlottesville, Virginia
VCU Massey Comprehensive Cancer Center Richmond, Virginia
Women's Cancer Care Associates Albany, New York
Yale Gynecologic Oncology New Haven, Connecticut

ASHBY: Accelerated Super-Hypofractionated Breast Brachytherapy (ASHBY)

Contact(s):

Massey IIT Research Operations - masseyepd@vcu.edu

Principal Investigator:

System ID: NCT06185205

Show full eligibility criteria

Inclusion Criteria:

* Female * New diagnosis of ductal carcinoma in situ (DCIS) and/or invasive breast carcinoma per histologic evaluation * Age 45-79 at diagnosis * Previous lumpectomy with surgical margins histologically free of invasive tumor and DCIS as determined by the pathologist. * T stage of Tis, T1, or T2. * T2 tumors must be ≤3 cm in maximum diameter * If the tumor is human epidermal growth factor receptor 2 (HER2)-positive, the patient must receive HER2-directed therapy. * For patients with invasive breast cancer, an axillary staging procedure must be performed (either sentinel node biopsy alone or axillary dissection \[with a minimum of 6 axillary nodes removed\]) and the axillary node\[s\] must be pathologically negative. * Note: N0(i+) is not an exclusion criterion. * Note: Patients meeting all of the following criteria are not required to undergo the axillary staging procedure: * ≥70 years of age * estrogen receptor, Her2 = human epidermal growth factor receptor 2, PR = progesterone receptor negative (ER+PR+HER2-) * G1-2 * Tumor ≤2 cm in size * Agrees to comply with aromatase inhibitor recommendation * Ability to understand and the willingness to sign a written informed consent document in English

Exclusion Criteria:

* Pregnant or breastfeeding * Active collagen-vascular disease * Paget's disease of the breast * History of DCIS or invasive breast cancer prior to the current diagnosis * Prior breast or thoracic radiation therapy (RT) for any condition * Multicentric carcinoma (DCIS or invasive) * Synchronous bilateral invasive or non-invasive breast cancer * Surgical margins that cannot be microscopically assessed or that are positive * Excision cavity that cannot be clearly delineated per the treating investigator * Any of the dosimetric treatment criteria defined in Section 6.1 have not been met. Patients who become ineligible due to inability to meet dosimetric criteria should not receive treatment as - defined in this protocol and will come off the study. Any subsequent adjuvant radiation will be delivered at the discretion of the treating physician * Medical, psychological, or social condition that, in the opinion of the investigator, may increase the patient's risk or limit the patient's adherence with study requirements

Interventions: DRUG: Accelerated partial breast irradiation

Conditions: Breast Cancer

Keywords: Breast Cancer, Ductal Carcinoma in situ (DCIS), Irradiation

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Location	Contacts
Virginia Commonwealth University Richmond, Virginia	Massey CTO Breast Team - (masseyctbrst@vcu.edu)

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (STRASS2)

Contact(s):

EORTC HQ - 1809@eortc.org

Principal Investigator:

System ID: NCT04031677

Show full eligibility criteria

• STRASS 2

Inclusion Criteria:

* Histologically proven primary high risk leiomyosarcoma (LMS) or Liposarcoma (LPS) of retroperitoneal space or infra-peritoneal spaces of pelvis. * LMS: * Any grade LMS can be included * Minimum size of LMS tumor should be 5 cm * LPS: * Diagnosis should be confirmed based on MDM2 (Mouse double minute 2 homolog) and CDK4 (Cyclin-dependent kinase 4) expression on IHC (immunohistochemistry), while proof of MDM2 amplification is highly recommended. * All grade 3 DDLPS can be included. * DDLPS with confirmed grade 2 on biopsy can be included when: * The grade 2 DDLPS has an FNCLCC score=5 (Fédération Nationale des Centres de Lutte Contre Le Cancer), and clear necrosis on imaging (whether or not present on the biopsy). * The tumors carry a high risk gene profile as determined by the Complexity INdex in SARComas (CINSARC-high) * Unifocal tumour * Resectable tumour: resectability is based on pre-operative imaging (CT-abdomen, potentially also with MRI) and has to be defined by the local treating sarcoma team. A patient is not considered resectable when the expectation is that only an R2 resection is feasible. * Criteria for non-resectability are: * Involvement of the superior mesenteric artery, aorta, coeliac trunk and/or portal vein * Involvement of bone * Growth into the spinal canal * Progression of retro-hepatic inferior vena cava leiomyosarcoma towards the right atrium * Infiltration of multiple major organs like liver, pancreas and or major vessels * Patient must have radiologically measurable disease (RECIST 1.1), as confirmed by imaging. CT thorax abdomen pelvis with IV contrast is the preferred imaging modality. In case of any contra-indications (medical or regulatory), it is allowed to perform a non-contrast CT thorax + MRI abdomen \& pelvis * Collection of tumour tissue for central pathology review is mandatory. * For patients with LMS: if there is not enough tissue for assessing the grading, this is acceptable. * If tumour tissue is not available for the central pathology review, patient will not be eligible. * If the biopsy was not done or the FFPE of the biopsy not available but at least 10 unstained slides or one pathological block are available for the central review, that will be considered as acceptable. * For the biopsy if fine needle aspiration (FNA) is performed instead of core needle biopsy (CNB) recommended by the standard guidelines, please contact the EORTC medical monitors for further evaluation. * Collection of tumour tissue and blood samples for translational research is mandatory. * In case there is not enough tissue for TR, a new biopsy is not required and if the patient fulfils all other eligibility criteria, he/she will be eligible. * If the blood samples are not collected, patient will not be eligible. * If the patient refuses the collection of biomaterial for TR, patient will not be eligible even if he/she fulfils all other eligibility criteria * ≥ 18 years old (no upper age limit) * WHO performance status ≤ 2 * Adequate haematological and organ function * American Society of Anaesthesiologist (ASA) score \< 3 * Women of childbearing potential (WOCBP) must have a negative serum pregnancy test within 3 days prior to randomization. Note: a woman is considered of childbearing potential, i.e., fertile, if she is following menarche. She remains of childbearing potential until she becomes post-menopausal or permanently sterile.Permanent sterilisation methods include hysterectomy, bilateral salpingectomy and bilateral oophorectomy. A postmenopausal state is defined as no menses for 12 months without an alternative medical cause. A high follicle stimulating hormone (FSH) level in the postmenopausal range may be used to confirm a post-menopausal state in women not using hormonal contraception or hormonal replacement therapy. However, in the absence of 12 consecutive months without menses, a single FSH measurement is insufficient. * WOCBP in both arms should use highly effective birth control measures, during the study treatment period and for at least 6 months after the last dose of chemotherapy or date of surgery (except for women receiving chemotherapy with ifosfamide who should continue contraception until 1 year after last day of treatment). A highly effective method of birth control is defined as a method which results in a low failure rate (i.e., less than 1% per year) when used consistently and correctly. * For men in the experimental arm: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures, and agreement to refrain from donating sperm. * Female subjects who are breast feeding should discontinue nursing prior to the first day of study treatment and until 6months after the last study treatment. * Before patient randomization, written informed consent must be given according to ICH/GCP, and national/local regulations. Exclusion criteria: * Sarcoma originating from bone structure, abdominal or gynecological viscera * Extension through the sciatic notch or across the diaphragm * Metastatic disease * Any previous surgery (excluding diagnostic biopsy), radiotherapy or systemic therapy for the present tumour * Hypersensitivity to doxorubicin, ifosfamide, dacarbazine or to any of their metabolites or to any of their excipients * Congestive heart failure * Angina pectoris * Myocardial infarction within 1 year before randomization * Uncontrolled arterial hypertension defined as blood pressure ≥ 150/100 mm Hg despite optimal medical therapy. Note: in case of high blood pressure: 1) initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; 2) blood pressure must be re-assessed on two occasions that are separated by a minimum of 1 hour. The mean SBP / DBP values from each blood pressure assessment must be ≤ 150/90mmHg in order for a patient to be eligible for the study. * Uncontrolled cardiac arrhythmia * Previous treatment with maximum cumulative doses (450mg/m² Doxorubicin or equivalent 900mg/m² Epirubicin) of doxorubicin, daunorubicin, epirubicin, idarubicin, and/or other anthracyclines and anthracenediones * Active and uncontrolled infections * Vaccination with live vaccines within 30 days prior to study entry * Inflammation of the urinary bladder (interstitial cystitis) and/or obstructions of the urine flow. * Other invasive malignancy within 5 years, with the exception of adequately treated non-melanoma skin cancer, localized cervical cancer, localized and Gleason ≤ 6prostate cancer. * Uncontrolled severe illness, infection, medical condition (including uncontrolled diabetes), other than the primary LPS or LMS of the retroperitoneum. * Female patients who are pregnant or breastfeeding or female and male patients of reproductive potential who are not willing to employ effective birth control method. * Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before randomization in the trial * Known contraindication to imaging tracer and to MRI
• Selection criteria for STREXIT 2 * Patients with histologically proven primary resectable localized high-risk DDLPS or LMS of retroperitoneal space or infra-peritoneal spaces of pelvis (as described in the inclusion criteria of STRASS 2) and amenable to receive chemotherapy but for whom the list of eligibility criteria for the study is too restrictive (tumour grading not available, inadequate organ function, concomitant diseases) * Patients who meet all eligibility criteria of STRASS 2 but do not consent to randomization or are not enrolled for any other reason. * Patients enrolled in a Registry collecting data on primary RPS patients in the centres participating in STRASS 2 (e.g., RESAR) and who satisfy the above criteria.
• Selection criteria for preferences for neoadjuvant chemotherapy in STRASS 2 substudy All patients recruited to STRASS 2 in participating centres (Australia +/- international sites) that are able to read, comprehend and write in English at a sufficient level to complete study materials.

Interventions: PROCEDURE: Surgery, DRUG: Preoperative chemotherapy

Conditions: Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma

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Location	Contacts
Aarhus University Hospitals - Aarhus University Hospital-Skejby Aarhus,
Aichi Cancer Center Nagoya,
Allegheny General Hospital Pittsburgh, Pennsylvania
Allegheny Valley Hospital Natrona Heights, Pennsylvania
BCCA - Vancouver Cancer Centre Vancouver, British Columbia
Bank Of Cyprus Oncology Centre Stróvolos,
Cancer Institute Hospital of Jfcr Kotoku, Tokyo
Carilion Roanoke Memorial Hospital Roanoke, Virginia
Centre Leon Berard Lyon,
Centro di Riferimento Oncologico Aviano,
Chris O'Brian Life House - Chris O'Brien Lifehouse Camperdown,
City of Hope Comprehensive Cancer Center Duarte, California
Clatterbridge cancer center Wirral,
Dana-Farber/Harvard Cancer Center Boston, Massachusetts
Dartmouth Hitchcock Med Ctr/Dartmouth Cancer Ctr Lebanon, New Hampshire
Duke University Medical Center Durham, North Carolina
Emory University Hospital Midtown Atlanta, Georgia
FHCC South Lake Union Seattle, Washington
Forbes Hospital Monroeville, Pennsylvania
Fox Chase Cancer Center Philadelphia, Pennsylvania
Fred Hutchinson Cancer Center Seattle, Washington
HMH-Hackensack University Medical Center Hackensack, New Jersey
Herlev Hospital - University Copenhagen Herlev, Copenhagen
Hopital Maisonneuve Rosemont Montreal, Quebec
Hopitaux Universitaires de Strasbourg - Hautepierre Strasbourg,
Hospital De La Santa Creu I Sant Pau Barcelona, Catalunya [cataluña]
Hospital General Universitario Gregorio Marañon Madrid,
Hospital Universitario San Carlos Madrid,
Huntsman Cancer Institute/University of Utah Salt Lake City, Utah
IRCCS - Fondazione Piemonte Inst di Candiolo Candiolo,
IRCCS - Istituto Nazionale dei Tumori Milan,
IRCCS - Istituto Oncologico Veneto Padova,
IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" Meldola,
Indiana Univ/Melvin and Bren Simon Cancer Center Indianapolis, Indiana
Institut Catala d'Oncologia - ICO Badalona - Hospital Germans Trias i Pujol Barcelona,
Institut Curie- Hopital de Paris Paris,
Institut Gustave Roussy Villejuif,
Institut du Cancer de Montpellier Montpellier,
Istituto Clinico Humanitas Rozzano,
Istituto Europeo Di Oncologia Milan,
James Graham Brown Ca Ctr at Univ of Louisville Louisville, Kentucky
Jefferson Hospital Jefferson Hills, Pennsylvania
Johns Hopkins Univ/Sidney Kimmel Cancer Center Baltimore, Maryland
Kanagawa Cancer Center Yokohama,
Kyushu University Hospital Fukuoka,
LSU Health Baton Rouge-North Clinic Baton Rouge, Louisiana
Laura and Issac Perlmutter Ca Ctr at NYU Langone New York, New York
Leeds Teaching Hospitals NHS Trust - St. James's University Hospital Leeds,
Leiden University Medical Centre Leiden, Southern Holland
London Regional Cancer Center London, Ontario
M D Anderson Cancer Center Houston, Texas
Maria Sklodowska-Curie Memorial Cancer Centre - Maria Sklodowska-Curie National Research Institute of Oncology Warsaw,
Marshfield Med Ctr-River Region at Stevens Point Stevens Point, Wisconsin
Marshfield Medical Center Marshfield, Wisconsin
Marshfield Medical Center Marshfield, Wisconsin
Marshfield Medical Center Marshfield, Wisconsin
Marshfield Medical Center Marshfield, Wisconsin
Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin
Masaryk Memorial Cancer Institute Brno,
Mayo Clinic Jacksonville, Florida
Mayo Clinic Hospital in Arizona Phoenix, Arizona
Mayo Clinic in Florida Jacksonville, Florida
Medical College of Wisconsin Milwaukee, Wisconsin
Moffitt Cancer Center Tampa, Florida
Moffitt Cancer Center - McKinley Campus Tampa, Florida
Moffitt Cancer Center-International Plaza Tampa, Florida
Mount Sinai Hospital New York, New York
NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital Glasgow,
NYU Langone Hospital - Long Island Mineola, New York
Nagoya University Hospital Showa-Ku Nagoya,
National Cancer Center Hospital Tokyo,
National Cancer Institute Putrajaya,
Nebraska Medicine-Bellevue Bellevue, Nebraska
Nebraska Medicine-Bellevue Bellevue, Nebraska
Newcastle Hospitals - Freeman Hospital, Northern Centre For Cancer Care Newcastle,
Niigata University Medical and Dental Hospital Niigata, Niigata,
Northwestern University Chicago, Illinois
Nottingham University Hospitals NHS Trust - City Hospital Nottingham,
Ohio State University Comprehensive Cancer Center Columbus, Ohio
Okayama University Hospital Okayama,
Oregon Health and Science University Portland, Oregon
Osaka International Cancer Institute Osaka,
Our Lady of the Lake Hospital Baton Rouge, Louisiana
Our Lady of the Lake Physician Group Baton Rouge, Louisiana
Oxford University Hospitals NHS Trust - Churchill Hospital Oxford, Oxfordshire
Pennsylvania Hospital Philadelphia, Pennsylvania
Peter Maccallum Cancer Institute Melbourne, Victoria
Policlinico Universitario Campus Bio-Medico- Oncology Center Roma,
Princess Alexandra Hospital - University Of Queensland Woolloongabba, Queensland
Radboudumc - Radboud University Medical Center Nijmegen Nijmegen,
Rhode Island Hospital Providence, Rhode Island
Roswell Park Cancer Institute Buffalo, New York
Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey
Saint Vincent Hospital Erie, Pennsylvania
Saitama Medical Center, Jichi Medical University Saitama,
Sanford Bismarck Medical Center Bismarck, North Dakota
Sanford Broadway Medical Center Fargo, North Dakota
Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota
Sanford Joe Lueken Cancer Center Bemidji, Minnesota
Sanford Roger Maris Cancer Center Fargo, North Dakota
Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota
Siteman Cancer Center-South Country Saint Louis, Missouri
Siteman Cancer Center-West County Creve Coeur, Missouri
Smilow Cancer Hospital Care Center - Guiford Guilford, Connecticut
Smilow Cancer Hospital Care Center - Waterford Waterford, Connecticut
Smilow Cancer Hospital Care Center - Westerly Westerly, Rhode Island
Smilow Cancer Hospital Care Center at Glastonbury Glastonbury, Connecticut
Smilow Cancer Hospital Care Center at Greenwich Greenwich, Connecticut
Smilow Cancer Hospital Care Center at Long Ridge Stamford, Connecticut
Smilow Cancer Hospital Care Center-Fairfield Fairfield, Connecticut
Smilow Cancer Hospital Care Center-Trumbull Trumbull, Connecticut
Smilow Cancer Hospital Care Ctr at Saint Francis Hartford, Connecticut
Smilow Cancer Hospital-Derby Care Center Derby, Connecticut
Smilow Cancer Hospital-Waterbury Care Center Waterbury, Connecticut
Stony Brook University Medical Center Stony Brook, New York
The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis Amsterdam,
The Ottawa Hospital - General Campus Ottawa,
The Research Institute of the McGill University Health Centre Montreal, Quebec
The Royal Marsden Hospital London, Other
Thomas Jefferson University Hospital Philadelphia, Pennsylvania
Tohoku University Hospital Sendai,
UC Irvine Health/Chao Family Comprehensive Ca Ctr Orange, California
UCHealth University of Colorado Hospital Aurora, Colorado
UPMC Hillman Cancer Center Pittsburgh, Pennsylvania
UniversitaetsMedizin Mannheim Mannheim,
Universitaetsklinikum Carl Gustav Carus Dresden,
Universitaetsmedizin Goettingen - Georg-August Universitaet Goettigen, Lower Saxony
University Hospitals Birmingham - Queen Elisabeth Medical Centre Birmingham,
University of Illinois at Chicago MBCCOP Chicago, Illinois
University of Kansas Cancer Center Kansas City, Kansas
University of Kansas Cancer Center-Overland Park Overland Park, Kansas
University of Kansas Hospital-Westwood Cancer Ctr Westwood, Kansas
University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan
University of Nebraska Medical Center Omaha, Nebraska
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma
University of Pennsylvania/Abramson Cancer Center Philadelphia, Pennsylvania
University of Rochester Rochester, New York
University of Washington Medical Center - Montlake Seattle, Washington
VCU Community Memorial Health Center South Hill, Virginia
VCU Massey Cancer Center at Hanover Medical Park Mechanicsville, Virginia
VCU Massey Cancer Center at Stony Point Richmond, Virginia
Vanderbilt University/Ingram Cancer Center Nashville, Tennessee
Virginia Commonwealth Univ/Massey Cancer Center Richmond, Virginia
Washington University School of Medicine - Siteman Cancer Center St Louis, Missouri
West Penn Hospital Pittsburgh, Pennsylvania
Wexford Health and Wellness Pavilion Wexford, Pennsylvania
Yale University New Haven, Connecticut
Yale-New Haven Hospital North Haven Medical Center North Haven, Connecticut
Yokohama City University Hospital Kanagawa,

Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors

Contact(s):

ctrrecruit@vcu.edu

Principal Investigator:

System ID: NCT06002828

Show full eligibility criteria

Interventions: PROCEDURE: Biospecimen Collection, OTHER: Quality-of-Life Assessment, OTHER: Questionnaire Administration

Conditions: Hodgkin Lymphoma, Non-Hodgkin Lymphoma

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Show 428 locations

Study Locations

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Location	Contacts
AMG Crystal Lake - Oncology Crystal Lake, Illinois	Site Public Contact - (advocateresearch@advocate.com)
AMG Libertyville - Oncology Libertyville, Illinois	Site Public Contact - (advocateresearch@advocatehealth.com)
Abbott-Northwestern Hospital Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Advanced Breast Care Center PLLC Warren, Michigan
Advocate Christ Medical Center Oak Lawn, Illinois
Advocate Good Samaritan Hospital Downers Grove, Illinois	Site Public Contact - (Barbara.barhamand@advocatehealth.com)
Advocate Good Shepherd Hospital Barrington, Illinois
Advocate High Tech Medical Park Palos Heights, Illinois	Site Public Contact - (ncorp@aah.org)
Advocate Illinois Masonic Medical Center Chicago, Illinois
Advocate Lutheran General Hospital Park Ridge, Illinois
Advocate Outpatient Center - Aurora Aurora, Illinois	Site Public Contact - (ncorp@aah.org)
Advocate Outpatient Center - Oak Lawn Oak Lawn, Illinois	Site Public Contact - (ncorp@aah.org)
Advocate Sherman Hospital Elgin, Illinois
Advocate South Suburban Hospital Hazel Crest, Illinois
Alaska Breast Care and Surgery LLC Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Alaska Oncology and Hematology LLC Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Alaska Women's Cancer Care Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Anchorage Associates in Radiation Medicine Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Anchorage Oncology Centre Anchorage, Alaska
Anchorage Radiation Therapy Center Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Ann M Wierman MD LTD Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Ascension Borgess Cancer Center Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Ascension Via Christi - Pittsburg Pittsburg, Kansas	Site Public Contact - (jennifer.jameson@ascension.org)
Aurora Bay Area Medical Group-Marinette Marinette, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora BayCare Medical Center Green Bay, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Grafton Grafton, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Kenosha South Kenosha, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Milwaukee Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Racine Racine, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Southern Lakes VLCC Burlington, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Health Care Germantown Health Center Germantown, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Medical Center in Summit Summit, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Saint Luke's Medical Center Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Saint Luke's South Shore Cudahy, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Sinai Medical Center Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora West Allis Medical Center West Allis, Wisconsin	Site Public Contact - (ncorp@aurora.org)
BASS Medical Group - Lennon Walnut Creek, California	Site Public Contact - (brenna.lindsey@bassmedicalgroup.com)
BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri
Baptist Cancer Center-Grenada Grenada, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Oxford Oxford, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Union County New Albany, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Bay Area Breast Surgeons Inc Emeryville, California
Bay Area Hospital Coos Bay, Oregon	Site Public Contact - (cherie.cox@bayareahospital.org)
Bay Area Tumor Institute Oakland, California
Bhadresh Nayak MD PC-Sterling Heights Sterling Heights, Michigan
Borgess Medical Center Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Boulder Community Foothills Hospital Boulder, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Bronson Battle Creek Battle Creek, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Bronson Methodist Hospital Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
CARTI Cancer center Little Rock, Arkansas	Site Public Contact - (Research@CARTI.com)
Cambridge Medical Center Cambridge, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Cancer Care Center of O'Fallon O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Center of Western Wisconsin New Richmond, Wisconsin	Site Public Contact - (mmcorc@healthpartners.com)
Cancer and Blood Specialists-Henderson Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan	Site Public Contact - (connie.szczepanek@crcwm.org)
Carle Cancer Center Urbana, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Effingham Effingham, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois	Site Public Contact - (Research@carle.com)
Carle at The Riverfront Danville, Illinois	Site Public Contact - (Research@Carle.com)
Caro Cancer Center Caro, Michigan	Site Public Contact - (lori.srebinski@ascension.org)
Carson Tahoe Regional Medical Center Carson City, Nevada	Site Public Contact - (research@sncrf.org)
Central Care Cancer Center - Bolivar Bolivar, Missouri	Site Public Contact - (aroland@kccop.org)
Central Care Cancer Center - Garden City Garden City, Kansas	Site Public Contact - (aroland@kccop.org)
Central Care Cancer Center - Great Bend Great Bend, Kansas	Site Public Contact - (aroland@kccop.org)
Centralia Oncology Clinic Centralia, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Chelsea Hospital Chelsea, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Cheyenne Regional Medical Center-West Cheyenne, Wyoming
Chilton Medical Center Pompton, New Jersey
Clackamas Radiation Oncology Center Clackamas, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Colorado Blood Cancer Institute Denver, Colorado
Community Medical Center Missoula, Montana	Site Public Contact - (HemonCCTrials@geisinger.edu)
Comprehensive Cancer Centers of Nevada Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Henderson Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Northwest Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Town Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Condell Memorial Hospital Libertyville, Illinois	Site Public Contact - (advocateresearch@advocatehealth.com)
Contra Costa Regional Medical Center Martinez, California
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Lakeland Hospitals - Niles Hospital Niles, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Reed City Hospital Reed City, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Cox Cancer Center Branson Branson, Missouri
CoxHealth South Hospital Springfield, Missouri
Crossroads Cancer Center Effingham, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Decatur Memorial Hospital Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Delbert Day Cancer Institute at PCRMC Rolla, Missouri	Site Public Contact - (research@phelpshealth.org)
Duluth Clinic Ashland Ashland, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Epic Care Cyberknife Center Walnut Creek, California
Epic Care Partners in Cancer Care Emeryville, California
Epic Care-Dublin Dublin, California
Essentia Health - Baxter Clinic Baxter, Minnesota
Essentia Health - Deer River Clinic Deer River, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - Ely Clinic Ely, Minnesota
Essentia Health - Fosston Fosston, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - International Falls Clinic International Falls, Minnesota
Essentia Health - Jamestown Clinic Jamestown, North Dakota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - Moose Lake Clinic Moose Lake, Minnesota
Essentia Health - Park Rapids Park Rapids, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Hibbing Clinic Hibbing, Minnesota
Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Saint Mary's Hospital - Superior Superior, Wisconsin
Essentia Health Saint Mary's Medical Center Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Sandstone Sandstone, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Virginia Clinic Virginia, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health-Hayward Clinic Hayward, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health-Spooner Clinic Spooner, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Fairbanks Memorial Hospital Fairbanks, Alaska	Site Public Contact - (Veronica.Stevenson@foundationhealth.org)
Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Lakes Medical Center Wyoming, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Northland Medical Center Princeton, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Southdale Hospital Edina, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Freeman Health System Joplin, Missouri	Site Public Contact - (LJCrockett@freemanhealth.com)
Freeman Physician Group of Pittsburg Pittsburg, Kansas	Site Public Contact - (BNMathew@freemanhealth.com)
Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Center Danville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Genesee Cancer and Blood Disease Treatment Center Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Genesee Hematology Oncology PC Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
GenesisCare USA - Fort Apache Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
GenesisCare USA - Henderson Henderson, Nevada	Site Public Contact - (research@sncrf.org)
GenesisCare USA - Las Vegas Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
GenesisCare USA - Vegas Tenaya Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Genesys Hurley Cancer Institute Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Gibbs Cancer Center-Gaffney Gaffney, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
Gibbs Cancer Center-Pelham Greer, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
Golisano Children's Hospital of Southwest Florida Fort Myers, Florida	Site Public Contact - (molly.arnstrom@leehealth.org)
Good Samaritan Regional Health Center Mount Vernon, Illinois
Great Lakes Cancer Management Specialists-Doctors Park East China, Michigan
Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb, Michigan
Great Lakes Cancer Management Specialists-Macomb Professional Building Warren, Michigan
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods, Michigan
Greater Regional Medical Center Creston, Iowa	Site Public Contact - (cancerresearch@mercydesmoines.org)
Gundersen Lutheran Medical Center La Crosse, Wisconsin	Site Public Contact - (cancerctr@gundersenhealth.org)
HSHS Saint Elizabeth's Hospital O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
HaysMed Hays, Kansas
Health Partners Inc Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Heartland Regional Medical Center Saint Joseph, Missouri	Site Public Contact - (linda.schumacher@mymlc.com)
Hematology Oncology Consultants-Clarkston Clarkston, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Hennepin County Medical Center Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Henry Ford Health Saint John Hospital Detroit, Michigan	Site Public Contact - (karen.forman@ascension.org)
Henry Ford Madison Heights Hospital - Breast Warren, Michigan
Henry Ford Saint John Hospital - Academic Grosse Pointe Woods, Michigan
Holy Cross Hospital Fort Lauderdale, Florida	Site Public Contact - (eileen.georgi@holy-cross.com)
Hope Cancer Care of Nevada Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Hope Cancer Care of Nevada-Pahrump Pahrump, Nevada	Site Public Contact - (research@sncrf.org)
Hope Cancer Center Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Hurley Medical Center Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Huron Gastroenterology PC Ypsilanti, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Illinois CancerCare - Washington Washington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Bloomington Bloomington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Canton Canton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Carthage Carthage, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Dixon Dixon, Illinois
Illinois CancerCare-Eureka Eureka, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Galesburg Galesburg, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Macomb Macomb, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Pekin Pekin, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peoria Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peru Peru, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Princeton Princeton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Iowa Methodist Medical Center Des Moines, Iowa
Jefferson Healthcare Port Townsend, Washington
Kadlec Clinic Hematology and Oncology Kennewick, Washington	Site Public Contact - (research@kadlecmed.org)
Katmai Oncology Group Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Kingman Regional Medical Center Kingman, Arizona	Site Public Contact - (research@sncrf.org)
Lake Regional Hospital Osage Beach, Missouri	Site Public Contact - (clinicaltrials@lakeregional.com)
Lakeview Hospital Stillwater, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Las Vegas Prostate Cancer Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Las Vegas Urology - Cathedral Rock Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Las Vegas Urology - Green Valley Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Las Vegas Urology - Pebble Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Las Vegas Urology - Pecos Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Las Vegas Urology - Smoke Ranch Las Vegas, Nevada	Site Public Contact - (research@smcrf.org)
Las Vegas Urology - Sunset Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Lawrence Memorial Hospital Lawrence, Kansas	Site Public Contact - (Stephanie.Norris@LMH.ORG)
Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Hazleton Hazleton, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
MGC Hematology Oncology-Union Union, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
MU Health Care Goldschmidt Cancer Center Jefferson City, Missouri
Macomb Hematology Oncology PC Warren, Michigan
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Clinic-Chippewa Center Chippewa Falls, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Clinic-Minocqua Center Minocqua, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Clinic-Wausau Center Wausau, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Ladysmith Ladysmith, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Neillsville Neillsville, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Weston Weston, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Marshfield Marshfield, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Mary Greeley Medical Center Ames, Iowa
McFarland Clinic - Ames Ames, Iowa	Site Public Contact - (ksoder@mcfarlandclinic.com)
McFarland Clinic - Boone Boone, Iowa
McFarland Clinic - Jefferson Jefferson, Iowa
McFarland Clinic - Marshalltown Marshalltown, Iowa
McFarland Clinic - Trinity Cancer Center Fort Dodge, Iowa
Memorial Hospital of Carbondale Carbondale, Illinois	Site Public Contact - (clinical.research@sih.net)
Memorial Medical Center Modesto, California	Site Public Contact - (pallante.beth@mhsil.com)
Mercy Cancer Center-West Lakes Clive, Iowa	Site Public Contact - (cancerresearch@mercydesmoines.org)
Mercy Clinic-Rolla-Cancer and Hematology Rolla, Missouri
Mercy Health - Paducah Cancer Center Paducah, Kentucky	Site Public Contact - (BJWarner@mercy.com)
Mercy Hospital Cedar Rapids, Iowa
Mercy Hospital Cedar Rapids, Iowa	Site Public Contact - (mmcorc@healthpartners.com)
Mercy Hospital Fort Smith Fort Smith, Arkansas
Mercy Hospital Joplin Joplin, Missouri	Site Public Contact - (esmeralda.carrillo@mercy.net)
Mercy Hospital Oklahoma City Oklahoma City, Oklahoma
Mercy Hospital Saint Louis St Louis, Missouri
Mercy Hospital South St Louis, Missouri	Site Public Contact - (Danielle.Werle@mercy.net)
Mercy Hospital Springfield Springfield, Missouri
Mercy Hospital Washington Washington, Missouri
Mercy Medical Center - Des Moines Des Moines, Iowa	Site Public Contact - (cancerresearch@mercydesmoines.org)
Mercy Medical Center-West Lakes West Des Moines, Iowa	Site Public Contact - (cancerresearch@mercydesmoines.org)
Methodist Medical Center of Illinois Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Michigan Healthcare Professionals Pontiac Pontiac, Michigan	Site Public Contact - (Emily.Crofts@trinity-health.org)
Miller-Dwan Hospital Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Minnesota Oncology - Burnsville Burnsville, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Mission Cancer and Blood - Ankeny Ankeny, Iowa
Mission Cancer and Blood - Des Moines Des Moines, Iowa
Mission Cancer and Blood - Laurel Des Moines, Iowa
Mission Cancer and Blood - West Des Moines Clive, Iowa
Mississippi Baptist Medical Center Jackson, Mississippi	Site Public Contact - (ecog.rss@jimmy.harvard.edu)
Missouri Baptist Medical Center St Louis, Missouri
Missouri Baptist Sullivan Hospital Sullivan, Missouri
Monmouth Medical Center Long Branch, New Jersey	Site Public Contact - (mary.danish@rwjbh.org)
Montefiore Medical Center - Moses Campus The Bronx, New York	Site Public Contact - (eskwak@montefiore.org)
Montefiore Medical Center-Einstein Campus The Bronx, New York	Site Public Contact - (eskwak@montefiore.org)
Montefiore Medical Center-Weiler Hospital The Bronx, New York	Site Public Contact - (eskwak@montefiore.org)
Monticello Cancer Center Monticello, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Morristown Medical Center Morristown, New Jersey
Mountain Blue Cancer Care Center - Swedish Englewood, Colorado
Munson Medical Center Traverse City, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
MyMichigan Medical Center Saginaw Saginaw, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
MyMichigan Medical Center Tawas Tawas City, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro, Arkansas	Site Public Contact - (Emily.Carvell@bmhcc.org)
New Ulm Medical Center New Ulm, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Newland Medical Associates-Clarkston Clarkston, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Newland Medical Associates-Pontiac Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Newton Medical Center Newton, New Jersey
North Memorial Medical Health Center Robbinsdale, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima, Washington	Site Public Contact - (Memorial-ClinicalTrials@yvmh.org)
Northwest Wisconsin Cancer Center Ashland, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
OSF Saint Francis Hospital and Medical Group Escanaba, Michigan	Site Public Contact - (ewd_research_admin@hshs.org)
Olathe Health Cancer Center Olathe, Kansas	Site Public Contact - (atheCCResearch@kumc.edu)
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa
Oncology Hematology Associates of Saginaw Valley PC Saginaw, Michigan	Site Public Contact - (lori.srebinski@ascension.org)
OptumCare Cancer Care at Charleston Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
OptumCare Cancer Care at Fort Apache Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
OptumCare Cancer Care at MountainView Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
OptumCare Cancer Care at Seven Hills Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Overlook Hospital Summit, New Jersey
PCR Oncology Arroyo Grande, California	Site Public Contact - (research@sncrf.org)
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Parkland Health Center - Farmington Farmington, Missouri
PeaceHealth Saint John Medical Center Longview, Washington	Site Public Contact - (kmakin-bond@peacehealth.org)
PeaceHealth Saint Joseph Medical Center Bellingham, Washington
PeaceHealth Southwest Medical Center Vancouver, Washington	Site Public Contact - (kmakin-bond@peacehealth.org)
PeaceHealth United General Medical Center Sedro-Woolley, Washington	Site Public Contact - (lkey@peacehealth.org)
Pocono Medical Center East Stroudsburg, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Presbyterian - Saint Lukes Medical Center - Health One Denver, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Prisma Health Cancer Institute - Butternut Greenville, South Carolina
Prisma Health Cancer Institute - Easley Easley, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Eastside Greenville, South Carolina
Prisma Health Cancer Institute - Faris Greenville, South Carolina
Prisma Health Cancer Institute - Greer Greer, South Carolina
Prisma Health Cancer Institute - Seneca Seneca, South Carolina
Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina
Providence Alaska Medical Center Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Providence Cancer Institute Clackamas Clinic Clackamas, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Medical Foundation - Santa Rosa Santa Rosa, California
Providence Newberg Medical Center Newberg, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Portland Medical Center Portland, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Queen of The Valley Napa, California
Providence Regional Cancer Partnership Everett, Washington	Site Public Contact - (marilyn.birchman@providence.org)
Providence Regional Cancer System-Aberdeen Aberdeen, Washington	Site Public Contact - (deidre.dillon@providence.org)
Providence Regional Cancer System-Centralia Centralia, Washington	Site Public Contact - (deidre.dillon@providence.org)
Providence Regional Cancer System-Lacey Lacey, Washington	Site Public Contact - (deidre.dillon@providence.org)
Providence Regional Cancer System-Shelton Shelton, Washington	Site Public Contact - (deidre.dillon@providence.org)
Providence Regional Cancer System-Yelm Yelm, Washington	Site Public Contact - (deidre.dillon@providence.org)
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank, California	Site Public Contact - (Najee.Boucher@providence.org)
Providence Saint Mary Regional Cancer Center Walla Walla, Washington	Site Public Contact - (Cheryl.Dodd@providence.org)
Providence Saint Vincent Medical Center Portland, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Santa Rosa Memorial Hospital Santa Rosa, California
Providence Willamette Falls Medical Center Oregon City, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Radiation Oncology Associates Reno, Nevada	Site Public Contact - (research@sncrf.org)
Radiation Oncology Centers of Nevada Central Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Radiation Oncology Centers of Nevada Southeast Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Regions Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Renown Regional Medical Center Reno, Nevada	Site Public Contact - (research@sncrf.org)
Rice Memorial Hospital Willmar, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Ridgeview Medical Center Waconia, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Riverwood Healthcare Center Aitkin, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Rocky Mountain Cancer Centers - Centennial Centennial, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers - Swedish Englewood, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Aurora Aurora, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Boulder Boulder, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Lakewood Lakewood, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Littleton Littleton, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Longmont Longmont, Colorado	Site Public Contact - (ResearchTracking@Centura.Org)
Rocky Mountain Cancer Centers-Midtown Denver, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Rose Denver, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Thornton Thornton, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rose Medical Center Denver, Colorado
Rush - Copley Medical Center Aurora, Illinois	Site Public Contact - (Cancer.Research@rushcopley.com)
Rush-Copley Healthcare Center Yorkville, Illinois	Site Public Contact - (Cancer.Research@rushcopley.com)
Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey
SIH Cancer Institute Carterville, Illinois	Site Public Contact - (clinical.research@sih.net)
Saint Anthony Regional Hospital Carroll, Iowa	Site Public Contact - (sbenson@iora.org)
Saint Anthony's Health Alton, Illinois
Saint Charles Health System Bend, Oregon	Site Public Contact - (nosall@stcharleshealthcare.org)
Saint Charles Health System-Redmond Redmond, Oregon
Saint Francis Cancer Center Greenville, South Carolina	Site Public Contact - (melissa_beckman@bshsi.org)
Saint Francis Hospital Federal Way, Washington	Site Public Contact - (melissa_beckman@bshsi.org)
Saint Francis Medical Center Cape Girardeau, Missouri	Site Public Contact - (sfmc@sfmc.net)
Saint Francis Regional Medical Center Shakopee, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Saint John Macomb-Oakland Hospital Warren, Michigan	Site Public Contact - (karen.forman@ascension.org)
Saint John's Hospital - Healtheast Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Saint Louis Cancer and Breast Institute-Ballwin Ballwin, Missouri
Saint Louis Cancer and Breast Institute-South City St Louis, Missouri
Saint Luke's Cancer Institute - Boise Boise, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Fruitland Fruitland, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Meridian Meridian, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Nampa Nampa, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Twin Falls Twin Falls, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Mary's Hospital Rhinelander, Wisconsin	Site Public Contact - (ecog.rss@jimmy.harvard.edu)
Saint Mary's Oncology/Hematology Associates of Marlette Marlette, Michigan	Site Public Contact - (lori.srebinski@ascension.org)
Saint Mary's Oncology/Hematology Associates of West Branch West Branch, Michigan	Site Public Contact - (lori.srebinski@ascension.org)
Saint Mary's Regional Medical Center Reno, Nevada
Saint Patrick Hospital - Community Hospital Missoula, Montana	Site Public Contact - (amy.hanneman@providence.org)
Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri
Salina Regional Health Center Salina, Kansas	Site Public Contact - (mleepers@srhc.com)
Sanford Broadway Medical Center Fargo, North Dakota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota	Site Public Contact - (OncologyClinicTrialsSF@sanfordhealth.org)
Sanford Joe Lueken Cancer Center Bemidji, Minnesota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford Roger Maris Cancer Center Fargo, North Dakota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota	Site Public Contact - (OncologyClinicalTrialsSF@SanfordHealth.org)
Skagit Regional Health Cancer Care Center Mount Vernon, Washington	Site Public Contact - (rcccclinicalresearch@skagitvalleyhospital.org)
Southeast Cancer Center Cape Girardeau, Missouri
Southern Illinois University School of Medicine Springfield, Illinois
Spartanburg Medical Center Spartanburg, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
Springfield Clinic Springfield, Illinois
Stanford Cancer Institute Palo Alto Palo Alto, California	Site Public Contact - (ccto-office@stanford.edu)
Summerlin Hospital Medical Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Sunrise Hospital and Medical Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Swedish Cancer Institute-Edmonds Edmonds, Washington	Site Public Contact - (PCRC-NCORP@Swedish.org)
Swedish Cancer Institute-Issaquah Issaquah, Washington	Site Public Contact - (PCRC-NCORP@Swedish.org)
Swedish Medical Center Englewood, Colorado
Swedish Medical Center-Ballard Campus Seattle, Washington	Site Public Contact - (PCRC-NCORP@Swedish.org)
Swedish Medical Center-Cherry Hill Seattle, Washington	Site Public Contact - (PCRC-NCORP@Swedish.org)
Swedish Medical Center-First Hill Seattle, Washington	Site Public Contact - (PCRC-NCORP@Swedish.org)
The Melanoma and Skin Cancer Institute Englewood, Colorado	Site Public Contact - (ryan.weight@theskincancerinstitute.com)
The Women's Imaging Center Denver, Colorado	Site Public Contact - (info@westernstatesncorp.org)
ThedaCare Cancer Care - Berlin Berlin, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - New London New London, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Oshkosh Oshkosh, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Shawano Shawano, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Waupaca Waupaca, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Regional Cancer Center Appleton, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Regional Medical Center - Neenah Neenah, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
Trinity Health Grand Rapids Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Medical Center - Brighton Brighton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Medical Center - Canton Canton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Muskegon Hospital Muskegon, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Regional Medical Center Fort Dodge, Iowa
United Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Unity Hospital Fridley, Minnesota
University Cancer Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
University Health Truman Medical Center Kansas City, Missouri
University Medical Center of Southern Nevada Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
University of Kansas Cancer Center Kansas City, Kansas	Site Public Contact - (KUCC_Navigation@kumc.edu)
University of Kansas Cancer Center - Lee's Summit Lee's Summit, Missouri	Site Public Contact - (KUCC_Navigation@kumc.edu)
University of Kansas Cancer Center - North Kansas City, Missouri	Site Public Contact - (KUCC_Navigation@kumc.edu)
University of Kansas Cancer Center at North Kansas City Hospital North Kansas City, Missouri	Site Public Contact - (KUCC_Navigation@kumc.edu)
University of Kansas Cancer Center-Overland Park Overland Park, Kansas	Site Public Contact - (KUCC_Navigation@kumc.edu)
University of Kansas Health System Saint Francis Campus Topeka, Kansas
University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas	Site Public Contact - (KUCC_Navigation@kumc.edu)
University of Michigan Health - Sparrow Lansing Lansing, Michigan	Site Public Contact - (harsha.trivedi@umhsparrow.org)
University of Michigan Health - West Wyoming, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
University of Nevada at Reno Veterans Affairs Medical Center Reno, Nevada	Site Public Contact - (research@sncrf.org)
University of Rochester Rochester, New York
University of Texas Health Science Center at San Antonio San Antonio, Texas	Site Public Contact - (phoresearchoffice@uthscsa.edu)
Urology Specialists of Nevada - Central Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Urology Specialists of Nevada - Green Valley Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Urology Specialists of Nevada - Northwest Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Urology Specialists of Nevada - Southwest Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Valley Medical Center Renton, Washington	Site Public Contact - (research@valleymed.org)
Valley Radiation Oncology Peru, Illinois
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia	Site Public Contact - (CTOclinops@vcu.edu)
West Michigan Cancer Center Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Western Illinois Cancer Treatment Center Galesburg, Illinois

Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial

Contact(s):

ctrrecruit@vcu.edu

Principal Investigator:

System ID: NCT05710328

Show full eligibility criteria

Inclusion Criteria:

* Patients (all genders) must be \>= 18 years of age. * Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible. * Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2. * Patient must have histologically confirmed HER2-positive primary invasive breast carcinoma by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines that has been determined by local testing. * Patient must have known (either positive or negative) hormone receptor (estrogen receptor \[ER\] or progesterone receptor \[PR\]) status by local testing, per ASCO/CAP guidelines. Patients with either hormone receptor-positive or hormone receptor- negative HER2-positive breast cancer are eligible. * Patient must have American Joint Committee on Cancer (AJCC) 8th Edition stage IIa-IIIc according to anatomic staging table at diagnosis and below criteria. * Patients without nodal involvement (cN0) are eligible if T size \> 2.0 cm (T2-4) * Patients with nodal involvement (cN1-3) are eligible if T2-4 * Patients with clinical T4d are not eligible * Patients with bilateral invasive breast cancers are eligible if both cancers are HER2-positive and at least one meets all protocol eligibility criteria and neither cancer renders the patient ineligible. * Patients with multiple ipsilateral invasive tumors are eligible as long as all tumors are HER2-positive and at least one tumor focus meets all eligibility criteria. Multiple lesions that appear part of the same index tumor do not require additional biopsy/HER2 testing. * Patient must plan to start a standard neoadjuvant pertuzumab (or other biosimilars) based regimen. * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of this imaging intervention are eligible for this trial. * Patients with human immunodeficiency virus (HIV) on effective anti-retroviral therapy with undetectable viral load within 6 months of registration are eligible for this trial. * Patient must be participating in the trial at an institution which has agreed to perform the imaging research studies, completed the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Center Group (ECOG-ACRIN) defined PET/CT scanner qualification procedures and received ECOG-ACRIN PET/CT scanner approval. * For patients who completed the baseline (T0) FDG-PET/CT PRIOR to registration, neoadjuvant pertuzumab-based regimen must start after study registration and within 21 days after the T0 scan. * Patients must not have used colony stimulating growth factors within 14 days prior to completing a T0 scan done prior to registration.

Exclusion Criteria:

* Patient must not have any prior treatment for the current breast cancer, including surgery, chemotherapy, hormonal therapy, radiation or experimental therapy. * Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the teratogenic effects of FDG in addition to the radiation exposure during PET/CT. All patients of childbearing potential must have a blood test or urine study within 7 days prior to registration to rule out pregnancy. * NOTE: A pregnancy test within 7 days prior to the T0 scan is also required but will only need to be done if a) the T0 scan is completed after study registration and b) if the pregnancy test done prior to registration is completed outside of the 7-day window. A patient of childbearing potential is defined as anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months). * Patient must not have any contraindication to FDG-PET/CT imaging which includes routine glucose values \> 200 mg/dL and severe claustrophobia.

Interventions: DRUG: Chemotherapy, PROCEDURE: Computed Tomography, OTHER: Fludeoxyglucose F-18, PROCEDURE: Positron Emission Tomography, PROCEDURE: Surgical Procedure

Conditions: Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Positive Breast Carcinoma, Invasive Breast Carcinoma

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Show 102 locations

Study Locations

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Location	Contacts
Abbott-Northwestern Hospital Minneapolis, Minnesota
Aurora Cancer Care-Southern Lakes VLCC Burlington, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Health Care Germantown Health Center Germantown, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Saint Luke's Medical Center Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Sinai Medical Center Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora West Allis Medical Center West Allis, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Oxford Oxford, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Bryn Mawr Health Center Newtown Square, Pennsylvania
Bryn Mawr Hospital Bryn Mawr, Pennsylvania	Site Public Contact - (turzoe@mlhs.org)
Cancer Center at Saint Joseph's Phoenix, Arizona	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Cancer Center-Metro Medical Center Bayamon Bayamón,
Carle Cancer Center Urbana, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Effingham Effingham, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois	Site Public Contact - (Research@carle.com)
Carle at The Riverfront Danville, Illinois	Site Public Contact - (Research@Carle.com)
Castle Medical Center Kailua, Hawaii	Site Public Contact - (ctsucontact@westat.com)
Centro Comprensivo de Cancer de UPR San Juan,
Chester County Hospital West Chester, Pennsylvania	Site Public Contact - (carolann.hoppes@pennmedicine.upenn.edu)
Community Medical Center Missoula, Montana	Site Public Contact - (HemonCCTrials@geisinger.edu)
Cooper Hospital University Medical Center Camden, New Jersey
CoxHealth South Hospital Springfield, Missouri
Dana-Farber Cancer Institute Boston, Massachusetts
Dell Seton Medical Center at The University of Texas Austin, Texas
Doctors Cancer Center Manatí,
FHCC South Lake Union Seattle, Washington
Fred Hutchinson Cancer Center Seattle, Washington
Geisinger Medical Center Danville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Guthrie Medical Group PC-Robert Packer Hospital Sayre, Pennsylvania
Hawaii Cancer Care - Westridge ‘Aiea, Hawaii	Site Public Contact - (info@hawaiicancercare.com)
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii	Site Public Contact - (i.webster@hawaiicancercare.com)
Huntsman Cancer Institute/University of Utah Salt Lake City, Utah	Site Public Contact - (cancerinfo@hci.utah.edu)
Indu and Raj Soin Medical Center Beavercreek, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Inspira Medical Center Mullica Hill Mullica Hill, New Jersey	Site Public Contact - (DeNigrisJ@ihn.org)
Inspira Medical Center Vineland Vineland, New Jersey
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland	Site Public Contact - (jhcccro@jhmi.edu)
Kapiolani Medical Center for Women and Children Honolulu, Hawaii
Kettering Medical Center Kettering, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Lankenau Medical Center Wynnewood, Pennsylvania	Site Public Contact - (turzoe@mlhs.org)
Los Angeles General Medical Center Los Angeles, California	Site Public Contact - (uscnorrisinfo@med.usc.edu)
Louisiana State University Health Science Center New Orleans, Louisiana	Site Public Contact - (emede1@lsuhsc.edu)
MD Anderson Cancer Center at Cooper-Voorhees Voorhees Township, New Jersey
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin
Marshfield Clinic-Minocqua Center Minocqua, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Ladysmith Ladysmith, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Neillsville Neillsville, Wisconsin
Marshfield Medical Center - Weston Weston, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Marshfield Marshfield, Wisconsin
Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Mayo Clinic in Florida Jacksonville, Florida
Mayo Clinic in Rochester Rochester, Minnesota
Mercy Hospital Cedar Rapids, Iowa
Mercy Hospital South St Louis, Missouri	Site Public Contact - (Danielle.Werle@mercy.net)
MetroHealth Medical Center Cleveland, Ohio	Site Public Contact - (ababal@metrohealth.org)
Minnesota Oncology - Burnsville Burnsville, Minnesota
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota
Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota
Montefiore Medical Center-Einstein Campus The Bronx, New York	Site Public Contact - (eskwak@montefiore.org)
Morristown Medical Center Morristown, New Jersey
Nebraska Medicine-Bellevue Bellevue, Nebraska	Site Public Contact - (unmcrsa@unmc.edu)
Nebraska Medicine-Village Pointe Omaha, Nebraska
Northwestern Medicine Cancer Center Delnor Geneva, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Cancer Center Kishwaukee DeKalb, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Lake Forest Hospital Lake Forest, Illinois	Site Public Contact - (cancertrials@northwestern.edu)
Northwestern University Chicago, Illinois	Site Public Contact - (cancer@northwestern.edu)
Ohio State University Comprehensive Cancer Center Columbus, Ohio	Site Public Contact - (Jamesline@osumc.edu)
Paoli Memorial Hospital Paoli, Pennsylvania	Site Public Contact - (turzoe@mlhs.org)
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Queen's Cancer Cenrer - POB I Honolulu, Hawaii
Queen's Cancer Center - Kuakini Honolulu, Hawaii
Queen's Medical Center Honolulu, Hawaii
Riddle Memorial Hospital Media, Pennsylvania	Site Public Contact - (turzoe@mlhs.org)
Roswell Park Cancer Institute Buffalo, New York	Site Public Contact - (askroswell@roswellpark.org)
Saint John's Cancer Institute Santa Monica, California
Saint Joseph's Regional Medical Center Paterson, New Jersey	Site Public Contact - (HallL@sjhmc.org)
Saint Luke's Cancer Institute - Twin Falls Twin Falls, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
San Juan City Hospital San Juan,
San Juan Community Oncology Group San Juan,
Sibley Memorial Hospital Washington D.C., District of Columbia	Site Public Contact - (jquiver1@jhmi.edu)
The James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky
UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina	Site Public Contact - (cancerclinicaltrials@med.unc.edu)
USC / Norris Comprehensive Cancer Center Los Angeles, California
United Hospital Saint Paul, Minnesota
University Medical Center New Orleans New Orleans, Louisiana	Site Public Contact - (emede1@lsuhsc.edu)
University of Alabama at Birmingham Cancer Center Birmingham, Alabama	Site Public Contact - (tmyrick@uab.edu)
University of Hawaii Cancer Center Honolulu, Hawaii
University of Nebraska Medical Center Omaha, Nebraska	Site Public Contact - (unmcrsa@unmc.edu)
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma	Site Public Contact - (ou-clinical-trials@ouhsc.edu)
University of Texas at Austin Austin, Texas	Site Public Contact - (irb@austin.utexas.edu)
University of Washington Medical Center - Montlake Seattle, Washington
University of Wisconsin Carbone Cancer Center - University Hospital Madison, Wisconsin	Site Public Contact - (clinicaltrials@cancer.wisc.edu)
Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia	Site Public Contact - (CTOclinops@vcu.edu)
Wayne State University/Karmanos Cancer Institute Detroit, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
Wilcox Memorial Hospital and Kauai Medical Clinic Lihue, Hawaii

Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults With Cancer

Contact(s):

Grace Hodges - hodgesg@vcu.edu

Principal Investigator:

System ID: NCT05958316

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Interventions: BEHAVIORAL: Computerized Symptom Capture Tool (C-SCAT) Intervention, BEHAVIORAL: Usual Care Control

Conditions: Symptoms and Signs, Cancer, Childhood Cancer

Keywords: Supportive Care, Symptom Management

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Study Locations

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Location	Contacts
Children's Mercy Hospital Kansas City, Missouri	Kristin Stegenga - (kstegenga@cmh.edu)
Seattle Children's Hospital @ University of Washington Seattle, Washington	Catherine F Macpherson - (CatherineFiona.Macpherson@seattlechildrens.org)
University of Utah Primary Children's Hospital Salt Lake City, Utah	Lauri Linder - (lauri.linder@nurs.utah.edu)
Virginia Commonwealth University Richmond, Virginia	Grace Hodges - (rkelswic@vcu.edu)

Mobile Health for Adherence in Breast Cancer Patients

Contact(s):

ctrrecruit@vcu.edu

Principal Investigator:

System ID: NCT06112613

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Inclusion Criteria:

* NON-PATIENT: Participants must be an oncology healthcare provider (i.e., oncologist, advanced practice provider, or oncology nurse) * NON-PATIENT: Participants must have taken care of at least one patient randomized to Arm B (CONCURxP) who had less than 85% adherence rate at 12 months as measured by the WiseBag * NON-PATIENT: Participant must speak English * NON-PATIENT: Participant must be employed at an National Cancer Institute Community Oncology Research Program (NCORP) site for at least 6 months * NON-PATIENT: Participant must be able to provide informed consent to participate in this study * PATIENT STEP 0: Patient must be \>= 18 years of age * PATIENT STEP 0: Patient must be fluent in written and spoken English OR patient must be fluent in written and spoken Spanish * PATIENT STEP 0: Patient must present with new or established pathologically proven hormone receptor (HR)+ HER2- metastatic breast cancer at the time of Step 0 * PATIENT STEP 0: Patient must have initiated any of the CKD4/6 inhibitors (palbociclib or Ibrance, ribociclib or Kisqali, abemaciclib or Verzenio) within 30 days prior to consenting to Step 0 or have received a prescription order with stated intent to initiate within 30 days following Step 0 consent * NOTE: Patients who have been treated previously with anticancer treatments other than CDK4/6 inhibitors are eligible * NOTE: CDK4/6 inhibitors must be provided/supplied as a single agent blister pack. If the medication is supplied as capsules in a pill bottle (e.g., Ibrance capsules), patient is not eligible * NOTE: Ribociclib (Kisqali) and abemaciclib (Verzenio) are only available in blister packs. Palbociclib (Ibrance) is the only CDK4/6 inhibitor that might be available in a capsule formulation. However, this is an outdated formulation and is rarely prescribed as a new start. The format of ordered palbociclib can be determined based on the prescription order * PATIENT STEP 0: Patients must not have been previously treated with any of the following CDK4/6 inhibitors: Palbociclib or Ibrance, ribociclib or Kisqali, and abemaciclib or Verzenio * PATIENT STEP 0: Patients must not already be enrolled in a therapeutic clinical trial that monitors CDK4/6 inhibitors * PATIENT STEP 0: Patient must confirm that they intend to receive their care or monitoring at an NCORP site * PATIENT STEP 0: Patient must have a personal mobile phone in which they are able and willing to send and receive text messages * NOTE: The restriction to those with mobile phone access with text messaging is based on the primary intention of the study which involves the use of text messaging to improve adherence * PATIENT STEP 0: Patient must have an email address * NOTE: The restriction to those with an email address is based on the primary intention of the study which involves patients responding to questions regarding their reasons for non-adherence after every missed dose to improve adherence * PATIENT STEP 0: Patient must have the ability to understand and the willingness to sign a written informed consent document * NOTE: Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available are not eligible * PATIENT STEP 0: Patient must not have an Eastern Cooperative Oncology Group (ECOG) performance status \>= 3 OR patient must not be deemed medically unable to participate in the study by the study investigators or an oncology clinician (i.e., referral to hospice) * PATIENT STEP 0: Patient must not be enrolled in other trials offering financial assistance * NOTE: Gift cards for survey completion, parking passes, or free medication provided as part of therapeutic trials are not considered financial assistance * PATIENT STEP 1: Patient must meet all the eligibility criteria for Step 0 * PATIENT STEP 1: Patient must have signed a written informed consent form * PATIENT STEP 1: Patient must have completed baseline survey within 30 days of the date of Step 0 Registration * PATIENT STEP 1: Patients must have initiated their CDK 4/6 inhibitors within 30 days of the date of Step 0 registration

Interventions: OTHER: Electronic Health Record Review, OTHER: Health Promotion and Education, PROCEDURE: Health Telemonitoring, OTHER: Interview, BEHAVIORAL: Patient Navigation, OTHER: Survey Administration, OTHER: Text Message-Based Navigation Intervention

Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Breast Carcinoma, HER2-Negative Breast Carcinoma, Hormone Receptor-Positive Breast Carcinoma

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Location	Contacts
Abbott-Northwestern Hospital Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Academic Hematology Oncology Specialists Grosse Pointe Woods, Michigan
Advanced Breast Care Center PLLC Warren, Michigan
Alegent Health Bergan Mercy Medical Center Omaha, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Alegent Health Immanuel Medical Center Omaha, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Alegent Health Lakeside Hospital Omaha, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Alegent Health Mercy Hospital Council Bluffs, Iowa
Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Ann M Wierman MD LTD Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Armes Family Cancer Center Findlay, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Ascension All Saints Hospital Racine, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Borgess Cancer Center Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Ascension Calumet Hospital Chilton, Wisconsin	Site Public Contact - (AWRI.inquiry@ascension.org)
Ascension Columbia Saint Mary's Hospital - Milwaukee Milwaukee, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Columbia Saint Mary's Hospital Ozaukee Mequon, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Mercy Hospital Oshkosh, Wisconsin	Site Public Contact - (AWRI.inquiry@ascension.org)
Ascension Saint Elizabeth Hospital Appleton, Wisconsin	Site Public Contact - (AWRI.inquiry@ascension.org)
Ascension Saint Francis - Reiman Cancer Center Franklin, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Saint Francis Hospital Milwaukee, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Saint John Hospital Detroit, Michigan	Site Public Contact - (karen.forman@ascension.org)
Ascension Saint Joseph Hospital Tawas City, Michigan	Site Public Contact - (lori.srebinski@ascension.org)
Ascension Saint Mary's Hospital Saginaw, Michigan	Site Public Contact - (lori.srebinski@ascension.org)
Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Southeast Wisconsin Hospital - Franklin Franklin, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus Milwaukee, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Augusta University Medical Center Augusta, Georgia	Site Public Contact - (ga_cares@augusta.edu)
BASS Medical Group - Lennon Walnut Creek, California	Site Public Contact - (brenna.lindsey@bassmedicalgroup.com)
Ballad Health Cancer Care - Kingsport Kingsport, Tennessee	Site Public Contact - (Justin.reynolds@balladhealth.org)
Baptist Cancer Center-Grenada Grenada, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Oxford Oxford, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Union County New Albany, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Beebe Health Campus Rehoboth Beach, Delaware	Site Public Contact - (research@beebehealthcare.org)
Beebe Medical Center Lewes, Delaware	Site Public Contact - (research@beebehealthcare.org)
Beebe South Coastal Health Campus Millville, Delaware	Site Public Contact - (research@beebehealthcare.org)
Benefis Sletten Cancer Institute Great Falls, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Bethesda North Hospital Cincinnati, Ohio	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Bhadresh Nayak MD PC-Sterling Heights Sterling Heights, Michigan
Billings Clinic Cancer Center Billings, Montana	Site Public Contact - (research@billingsclinic.org)
Billings Clinic-Cody Cody, Wyoming	Site Public Contact - (research@billingsclinic.org)
Blanchard Valley Hospital Findlay, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Bon Secours Cancer Institute at Reynolds Crossing Richmond, Virginia	Site Public Contact - (Anne_caramella@bshsi.org)
Bon Secours Memorial Regional Medical Center Mechanicsville, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Richmond Community Hospital Richmond, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Saint Francis Medical Center Midlothian, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Saint Mary's Hospital Richmond, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Westchester Emergency Center Midlothian, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Borgess Medical Center Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Boulder Community Foothills Hospital Boulder, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Bozeman Health Deaconess Hospital Bozeman, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Bristol Regional Medical Center Bristol, Tennessee	Site Public Contact - (justin.reynolds@wellmont.org)
Bronson Battle Creek Battle Creek, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Bronson Methodist Hospital Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
CARTI Cancer center Little Rock, Arkansas	Site Public Contact - (Research@CARTI.com)
CHI Health Good Samaritan Kearney, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Cambridge Medical Center Cambridge, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Cancer Center at Saint Joseph's Phoenix, Arizona	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Cancer Center of Western Wisconsin New Richmond, Wisconsin	Site Public Contact - (mmcorc@healthpartners.com)
Cancer Center-Metro Medical Center Bayamon Bayamón,
Cancer and Blood Specialists-Henderson Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan	Site Public Contact - (connie.szczepanek@crcwm.org)
Carle Cancer Center Urbana, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Effingham Effingham, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois	Site Public Contact - (Research@carle.com)
Carle at The Riverfront Danville, Illinois	Site Public Contact - (Research@Carle.com)
Caro Cancer Center Caro, Michigan	Site Public Contact - (lori.srebinski@ascension.org)
Carson Tahoe Regional Medical Center Carson City, Nevada	Site Public Contact - (research@sncrf.org)
Central Care Cancer Center - Bolivar Bolivar, Missouri	Site Public Contact - (aroland@kccop.org)
Central Care Cancer Center - Garden City Garden City, Kansas	Site Public Contact - (aroland@kccop.org)
Central Care Cancer Center - Great Bend Great Bend, Kansas	Site Public Contact - (aroland@kccop.org)
Centro Comprensivo de Cancer de UPR San Juan,	Site Public Contact - (ecog.rss@jimmy.harvard.edu)
Chelsea Hospital Chelsea, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Cheyenne Regional Medical Center-West Cheyenne, Wyoming
Chilton Medical Center Pompton, New Jersey
Christiana Care - Union Hospital Elkton, Maryland	Site Public Contact - (frank.crum@christianacare.org)
Christiana Care Health System-Christiana Hospital Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Christiana Care Health System-Concord Health Center Chadds Ford, Pennsylvania	Site Public Contact - (lbarone@christianacare.org)
Christiana Care Health System-Wilmington Hospital Wilmington, Delaware	Site Public Contact - (lbarone@christianacare.org)
Colorado Blood Cancer Institute Denver, Colorado
Commonwealth Cancer Center-Corbin Corbin, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Community Hospital of Anaconda Anaconda, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Community Medical Center Missoula, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Community Medical Center Missoula, Montana	Site Public Contact - (HemonCCTrials@geisinger.edu)
Comprehensive Cancer Centers of Nevada Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Henderson Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Northwest Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Town Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Contra Costa Regional Medical Center Martinez, California
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Lakeland Hospitals - Niles Hospital Niles, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Reed City Hospital Reed City, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Cox Cancer Center Branson Branson, Missouri
CoxHealth South Hospital Springfield, Missouri
Creighton University Medical Center Omaha, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Dayton Physician LLC - Englewood Dayton, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Dayton Physicians LLC - Troy Troy, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Dayton Physicians LLC-Atrium Franklin, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Dayton Physicians LLC-Miami Valley South Centerville, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Dayton Physicians LLC-Wayne Greenville, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Delbert Day Cancer Institute at PCRMC Rolla, Missouri	Site Public Contact - (research@phelpshealth.org)
Doctors Cancer Center Manatí,
Emory University Hospital/Winship Cancer Institute Atlanta, Georgia
Fairbanks Memorial Hospital Fairbanks, Alaska	Site Public Contact - (Veronica.Stevenson@foundationhealth.org)
Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Lakes Medical Center Wyoming, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Northland Medical Center Princeton, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Southdale Hospital Edina, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Flaget Memorial Hospital Bardstown, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Freeman Health System Joplin, Missouri	Site Public Contact - (LJCrockett@freemanhealth.com)
Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Center Danville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Genesee Cancer and Blood Disease Treatment Center Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Genesee Hematology Oncology PC Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
GenesisCare USA - Fort Apache Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
GenesisCare USA - Henderson Henderson, Nevada	Site Public Contact - (research@sncrf.org)
GenesisCare USA - Las Vegas Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
GenesisCare USA - Vegas Tenaya Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Genesys Hurley Cancer Institute Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Good Samaritan Hospital - Cincinnati Cincinnati, Ohio	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Good Samaritan Regional Health Center Mount Vernon, Illinois
Great Falls Clinic Great Falls, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Great Lakes Cancer Management Specialists-Doctors Park East China, Michigan
Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb, Michigan
Great Lakes Cancer Management Specialists-Macomb Professional Building Warren, Michigan
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods, Michigan
Greater Dayton Cancer Center Kettering, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Hackettstown Medical Center Hackettstown, New Jersey
Health Partners Inc Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Heartland Regional Medical Center Saint Joseph, Missouri	Site Public Contact - (linda.schumacher@mymlc.com)
Helen F Graham Cancer Center Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Hematology Oncology Consultants-Clarkston Clarkston, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Hennepin County Medical Center Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Holy Cross Hospital Fort Lauderdale, Florida	Site Public Contact - (eileen.georgi@holy-cross.com)
Hope Cancer Care of Nevada Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Hope Cancer Care of Nevada-Pahrump Pahrump, Nevada	Site Public Contact - (research@sncrf.org)
Hope Cancer Center Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Hurley Medical Center Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Huron Gastroenterology PC Ypsilanti, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Idaho Urologic Institute-Meridian Meridian, Idaho	Site Public Contact - (stephanie.couch@stjoeshealth.org)
Indu and Raj Soin Medical Center Beavercreek, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Jefferson Healthcare Port Townsend, Washington
Kaiser Permanente - Harbor City Harbor City, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente - Panorama City Panorama City, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente Los Angeles Medical Center Los Angeles, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente West Los Angeles Los Angeles, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-Anaheim Anaheim, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-Baldwin Park Baldwin Park, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-Bellflower Bellflower, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-Fontana Fontana, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-Franklin Denver, Colorado	Site Public Contact - (kristi.m.bronkan@kp.org)
Kaiser Permanente-Irvine Irvine, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-Lone Tree Lone Tree, Colorado	Site Public Contact - (kristi.m.bronkan@kp.org)
Kaiser Permanente-Ontario Ontario, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-Riverside Riverside, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-Rock Creek Lafayette, Colorado	Site Public Contact - (kristi.m.bronkan@kp.org)
Kaiser Permanente-San Diego Mission San Diego, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-San Diego Zion San Diego, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-San Marcos San Marcos, California	Site Public Contact - (clinical.trials@kp.org)
Kaiser Permanente-Woodland Hills Woodland Hills, California	Site Public Contact - (clinical.trials@kp.org)
Kalispell Regional Medical Center Kalispell, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Kettering Medical Center Kettering, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Kingman Regional Medical Center Kingman, Arizona	Site Public Contact - (research@sncrf.org)
Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Lake Regional Hospital Osage Beach, Missouri	Site Public Contact - (clinicaltrials@lakeregional.com)
Lakeview Hospital Stillwater, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Las Vegas Prostate Cancer Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Las Vegas Urology - Cathedral Rock Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Las Vegas Urology - Green Valley Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Las Vegas Urology - Pebble Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Las Vegas Urology - Pecos Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Las Vegas Urology - Smoke Ranch Las Vegas, Nevada	Site Public Contact - (research@smcrf.org)
Las Vegas Urology - Sunset Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Hazleton Hazleton, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Longmont United Hospital Longmont, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Louisiana Hematology Oncology Associates Baton Rouge, Louisiana	Site Public Contact - (clinicalresearch@marybird.com)
Louisiana Hematology Oncology Associates LLC Baton Rouge, Louisiana	Site Public Contact - (clinicalresearch@marybird.com)
Louisiana State University Health Science Center New Orleans, Louisiana	Site Public Contact - (emede1@lsuhsc.edu)
Low Country Cancer Care Savannah, Georgia	Site Public Contact - (Lorraine.OHara@hcahealthcare.com)
Macomb Hematology Oncology PC Warren, Michigan
Maimonides Medical Center Brooklyn, New York
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Clinic-Chippewa Center Chippewa Falls, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Clinic-Minocqua Center Minocqua, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Clinic-Wausau Center Wausau, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Ladysmith Ladysmith, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Neillsville Neillsville, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Weston Weston, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Marshfield Marshfield, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Mary Bird Perkins Cancer Center Baton Rouge, Louisiana	Site Public Contact - (clinicalresearch@marybird.com)
Mary Greeley Medical Center Ames, Iowa
McFarland Clinic - Ames Ames, Iowa	Site Public Contact - (ksoder@mcfarlandclinic.com)
McFarland Clinic - Boone Boone, Iowa
McFarland Clinic - Jefferson Jefferson, Iowa
McFarland Clinic - Marshalltown Marshalltown, Iowa
McFarland Clinic - Trinity Cancer Center Fort Dodge, Iowa
Medical Oncology Hematology Consultants PA Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Memorial Health University Medical Center Savannah, Georgia	Site Public Contact - (Lorraine.OHara@hcahealthcare.com)
Mercy Cancer Center Merced, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Carmichael Carmichael, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Elk Grove Elk Grove, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Rocklin Rocklin, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Sacramento Sacramento, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Clinic-Rolla-Cancer and Hematology Rolla, Missouri
Mercy Health - Paducah Medical Oncology and Hematology Paducah, Kentucky	Site Public Contact - (BJWarner@mercy.com)
Mercy Hospital Cedar Rapids, Iowa
Mercy Hospital Cedar Rapids, Iowa	Site Public Contact - (mmcorc@healthpartners.com)
Mercy Hospital Fort Smith Fort Smith, Arkansas
Mercy Hospital Joplin Joplin, Missouri	Site Public Contact - (esmeralda.carrillo@mercy.net)
Mercy Hospital Oklahoma City Oklahoma City, Oklahoma
Mercy Hospital Saint Louis St Louis, Missouri
Mercy Hospital South St Louis, Missouri	Site Public Contact - (Danielle.Werle@mercy.net)
Mercy Hospital Springfield Springfield, Missouri
Mercy Hospital Washington Washington, Missouri
Mercy Medical Center Springfield, Massachusetts	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy San Juan Medical Center Carmichael, California	Site Public Contact - (OncologyResearch@DignityHealth.org)
Michigan Breast Specialists-Warren Warren, Michigan
Michigan Healthcare Professionals Pontiac Pontiac, Michigan	Site Public Contact - (Emily.Crofts@trinity-health.org)
Midlands Community Hospital Papillion, Nebraska
Minnesota Oncology - Burnsville Burnsville, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Mission Cancer and Blood - Ankeny Ankeny, Iowa
Mission Cancer and Blood - Des Moines Des Moines, Iowa
Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mission Hope Medical Oncology - Santa Maria Santa Maria, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mississippi Baptist Medical Center Jackson, Mississippi	Site Public Contact - (ecog.rss@jimmy.harvard.edu)
Montefiore Medical Center - Moses Campus The Bronx, New York	Site Public Contact - (eskwak@montefiore.org)
Montefiore Medical Center-Einstein Campus The Bronx, New York	Site Public Contact - (eskwak@montefiore.org)
Montefiore Medical Center-Weiler Hospital The Bronx, New York	Site Public Contact - (eskwak@montefiore.org)
Monticello Cancer Center Monticello, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Morristown Medical Center Morristown, New Jersey
Mountain Blue Cancer Care Center - Swedish Englewood, Colorado
Munson Medical Center Traverse City, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro, Arkansas	Site Public Contact - (Emily.Carvell@bmhcc.org)
New Ulm Medical Center New Ulm, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Newland Medical Associates-Clarkston Clarkston, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Newland Medical Associates-Pontiac Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Newton Medical Center Newton, New Jersey
North Memorial Medical Health Center Robbinsdale, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima, Washington	Site Public Contact - (Memorial-ClinicalTrials@yvmh.org)
Ochsner Medical Center Jefferson New Orleans, Louisiana	Site Public Contact - (Elisemarie.curry@ochsner.org)
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa
Oncology Hematology Associates of Saginaw Valley PC Saginaw, Michigan	Site Public Contact - (lori.srebinski@ascension.org)
Oncology Hematology Care Inc-Kenwood Cincinnati, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
OptumCare Cancer Care at Charleston Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
OptumCare Cancer Care at Fort Apache Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
OptumCare Cancer Care at MountainView Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
OptumCare Cancer Care at Seven Hills Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Orion Cancer Care Findlay, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Overlook Hospital Summit, New Jersey
PCR Oncology Arroyo Grande, California	Site Public Contact - (research@sncrf.org)
PROncology San Juan,	Site Public Contact - (info@PRoncology.com)
Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Penrose-Saint Francis Healthcare Colorado Springs, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Phoebe Putney Memorial Hospital Albany, Georgia	Site Public Contact - (ga_cares@augusta.edu)
Pocono Medical Center East Stroudsburg, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Presbyterian - Saint Lukes Medical Center - Health One Denver, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Puerto Rico Hematology Oncology Group Bayamón,
Radiation Oncology Associates Reno, Nevada	Site Public Contact - (research@sncrf.org)
Radiation Oncology Centers of Nevada Central Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Radiation Oncology Centers of Nevada Southeast Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Regions Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Reid Health Richmond, Indiana	Site Public Contact - (clinical.trials@daytonncorp.org)
Renown Regional Medical Center Reno, Nevada	Site Public Contact - (research@sncrf.org)
Rice Memorial Hospital Willmar, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Ridgeview Medical Center Waconia, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Rocky Mountain Cancer Centers - Centennial Centennial, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers - Swedish Englewood, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Aurora Aurora, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Boulder Boulder, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Lakewood Lakewood, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Littleton Littleton, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Longmont Longmont, Colorado	Site Public Contact - (ResearchTracking@Centura.Org)
Rocky Mountain Cancer Centers-Midtown Denver, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Penrose Colorado Springs, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Rocky Mountain Cancer Centers-Rose Denver, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Thornton Thornton, Colorado	Site Public Contact - (info@westernstatesncorp.org)
Rush - Copley Medical Center Aurora, Illinois	Site Public Contact - (Cancer.Research@rushcopley.com)
Rush-Copley Healthcare Center Yorkville, Illinois	Site Public Contact - (Cancer.Research@rushcopley.com)
Saint Alphonsus Cancer Care Center-Baker City Baker City, Oregon	Site Public Contact - (mccinfo@mtcancer.org)
Saint Alphonsus Cancer Care Center-Boise Boise, Idaho	Site Public Contact - (stephanie.couch@stjoeshealth.org)
Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho	Site Public Contact - (stephanie.couch@stjoeshealth.org)
Saint Alphonsus Cancer Care Center-Nampa Nampa, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Saint Alphonsus Cancer Care Center-Ontario Ontario, Oregon	Site Public Contact - (mccinfo@mtcancer.org)
Saint Anthony Hospital Lakewood, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Anthony's Health Alton, Illinois
Saint Elizabeth Boardman Hospital Boardman, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Saint Elizabeth Regional Medical Center Lincoln, Nebraska
Saint Elizabeth Youngstown Hospital Youngstown, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Saint Francis Cancer Center Greenville, South Carolina	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Francis Regional Medical Center Shakopee, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Saint John Macomb-Oakland Hospital Warren, Michigan	Site Public Contact - (karen.forman@ascension.org)
Saint John's Hospital - Healtheast Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Saint Joseph Hospital Nashua, New Hampshire	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph Hospital East Lexington, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph London London, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph Mount Sterling Mount Sterling, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph Radiation Oncology Resource Center Lexington, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph Warren Hospital Warren, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Saint Louis Cancer and Breast Institute-Ballwin Ballwin, Missouri
Saint Louis Cancer and Breast Institute-South City St Louis, Missouri
Saint Mary Corwin Medical Center Pueblo, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Mary's Hospital Rhinelander, Wisconsin	Site Public Contact - (ecog.rss@jimmy.harvard.edu)
Saint Mary's Oncology/Hematology Associates of Marlette Marlette, Michigan	Site Public Contact - (lori.srebinski@ascension.org)
Saint Mary's Oncology/Hematology Associates of West Branch West Branch, Michigan	Site Public Contact - (lori.srebinski@ascension.org)
Saint Mary's Regional Medical Center Reno, Nevada	Site Public Contact - (research@sncrf.org)
Saint Michael Cancer Center Silverdale, Washington	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin	Site Public Contact - (ewd_research_admin@hshs.org)
San Juan City Hospital San Juan,
San Juan Community Oncology Group San Juan,
Sanford Bismarck Medical Center Bismarck, North Dakota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford Broadway Medical Center Fargo, North Dakota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota	Site Public Contact - (OncologyClinicTrialsSF@sanfordhealth.org)
Sanford Cancer Center Worthington Worthington, Minnesota
Sanford Joe Lueken Cancer Center Bemidji, Minnesota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford Medical Center Fargo Fargo, North Dakota
Sanford Roger Maris Cancer Center Fargo, North Dakota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford South University Medical Center Fargo, North Dakota
Sanford Thief River Falls Medical Center Thief River Falls, Minnesota
Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota	Site Public Contact - (OncologyClinicalTrialsSF@SanfordHealth.org)
Shenandoah Oncology PC Winchester, Virginia	Site Public Contact - (William.Houck@usoncology.com)
South Georgia Medical Center/Pearlman Cancer Center Valdosta, Georgia	Site Public Contact - (maryann.heddon@sgmc.org)
Southpointe-Sanford Medical Center Fargo Fargo, North Dakota
Southwest Oncology PC Durango, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Southwest VA Regional Cancer Center Norton, Virginia	Site Public Contact - (justin.reynolds@wellmont.org)
Summerlin Hospital Medical Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Sunrise Hospital and Medical Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Terrebonne General Medical Center Houma, Louisiana	Site Public Contact - (ann.hooks@tgmc.com)
The Melanoma and Skin Cancer Institute Englewood, Colorado	Site Public Contact - (ryan.weight@theskincancerinstitute.com)
The Women's Imaging Center Denver, Colorado	Site Public Contact - (info@westernstatesncorp.org)
ThedaCare Cancer Care - Berlin Berlin, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - New London New London, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Oshkosh Oshkosh, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Shawano Shawano, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Waupaca Waupaca, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Regional Cancer Center Appleton, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Regional Medical Center - Neenah Neenah, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
TriHealth Cancer Institute-Anderson Cincinnati, Ohio	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
TriHealth Cancer Institute-Westside Cincinnati, Ohio	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Trinity Health Grand Rapids Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Medical Center - Brighton Brighton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Medical Center - Canton Canton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Muskegon Hospital Muskegon, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California
United Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
University Cancer Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
University Medical Center New Orleans New Orleans, Louisiana	Site Public Contact - (emede1@lsuhsc.edu)
University Medical Center of Southern Nevada Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
University of Michigan Health - Sparrow Lansing Lansing, Michigan	Site Public Contact - (harsha.trivedi@umhsparrow.org)
University of Michigan Health - West Wyoming, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
University of New Mexico Cancer Center Albuquerque, New Mexico	Site Public Contact - (HSC-ClinicalTrialInfo@salud.unm.edu)
Urology Specialists of Nevada - Central Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Urology Specialists of Nevada - Green Valley Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Urology Specialists of Nevada - Northwest Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Urology Specialists of Nevada - Southwest Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
VCU Community Memorial Health Center South Hill, Virginia	Site Public Contact - (nemer.elmouallem@vcuhealth.org)
VCU Massey Cancer Center at Stony Point Richmond, Virginia	Site Public Contact - (ctoclinops@vcu.edu)
Valley Medical Center Renton, Washington	Site Public Contact - (research@valleymed.org)
Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia	Site Public Contact - (CTOclinops@vcu.edu)
Walter Knox Memorial Hospital Emmett, Idaho	Site Public Contact - (stephanie.couch@stjoeshealth.org)
Wayne Hospital Greenville, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Welch Cancer Center Sheridan, Wyoming	Site Public Contact - (mccinfo@mtcancer.org)
Wellmont Holston Valley Hospital and Medical Center Kingsport, Tennessee	Site Public Contact - (justin.reynolds@wellmont.org)
Wellmont Medical Associates-Bristol Bristol, Virginia	Site Public Contact - (justin.reynolds@wellmont.org)
West Michigan Cancer Center Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Woodland Memorial Hospital Woodland, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer (STRIKE)

Contact(s):

Aishwarya Vijendran - guprotocols@alliancenctn.org

Principal Investigator:

System ID: NCT06661720

Show full eligibility criteria

Inclusion Criteria:

* • Histologically confirmed diagnosis of RCC with clear cell component with or without sarcomatoid features following complete resection of the primary tumor (radical or partial nephrectomy) * Note: Patients with microscopically positive soft tissue or vascular margins without gross residual disease are permitted * Intermediate-high risk RCC: * pT2 grade 4 or sarcomatoid features, N0M0 * pT3 any grade N0, M0 * High-risk RCC * pT4, any grade, N0, M0 * pT, any stage., any grade, N+, M0 * cM1 no evidence of disease (NED) RCC * Participants who have had resection of primary tumor (radical or partical nephrectomy) and resection or definitive radiation or ablation of solid, isolated, soft tissue metastases (excluding brain and bone lesions) at the time of primary tumor removal (synchronous) or ≤1 year from primary tumor removal (metachronous) * Surgery (radical or partial nephrectomy or metastasectomy or ablation) \> 4 weeks but =\< 16 weeks prior to study registration with no ongoing complications from surgery * No evidence of disease at time of randomization as assessed by investigator by either CT or MRI scan of the brain and chest, abdomen and pelvis * No prior systemic treatment for RCC * Age \>= 18 years * Eastern Cooperative Oncology Group (ECOG) performance status =\< 2 (or Karnofsky \>= 60%) * Absolute neutrophil count (ANC) \>= 1,000/mm\^3 * Platelet count \>= 100,000/mm\^3 * Hemoglobin \>= 8 g/dL * Total bilirubin =\< 3 x upper limit of normal (ULN) * Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 3 x upper limit of normal (ULN) * Calculated (calc.) creatinine clearance \>= 30 mL/min (using Cockcroft Gault equation or the estimated glomerular filtration rate from the modification of diet in renal disease trial) * Urine protein =\< 1+ on urine analysis (UA) or urine protein creatinine ration (UPCR) \< 2mg/mg * Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative pregnancy test is required =\< 14 days prior to registration * HIV status: HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial * Hepatitis * Hepatitis B: For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. Patients with resolved HBV infection, defined as positive hepatitis B core antibody (anti-HBc) and negative hepatitis B surface antigen (HbsAg), are eligible * Hepatitis C: Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load * Cardiac Disease: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class IIB or better * No history of myocarditis * No history of clinically significant pneumonitis * No uncontrolled hypertension (systolic blood pressure \[BP\] \> 150 mm Hg or diastolic BP \> 90 mm Hg) documented on 2 consecutive measurements taken at least 2 hours apart * No serious non-healing wound, ulcer or bone fracture within 28 days prior to registration * No serious/active infection requiring parenteral antibiotics * No moderate or severe hepatic impairment (child-Pugh B or C) * No significant bleeding disorders within 1 month prior to registration, for example: * Hematemesis, hematochezia or other gastrointestinal bleeding grade 3 or higher * Hemoptysis of pulmonary bleeding grade 3 or higher * Hematuria or other genitourinary bleeding grade 3 or higher * No history of allogeneic organ transplantation * No history of allergy of hypersensitivity to study drugs or components * No condition requiring systemic treatment with either corticosteroid (\> 10 mg daily or prednisone equivalent) within 14 days of treatment initiation or other immunosuppressive medications within 30 days of randomization. Inhaled or topical steroids and adrenal replacement doses ≤10 mg daily prednisone equivalent are permitted in absence of active autoimmune disease * No active peptic ulcer disease, inflammatory bowel disease, ulcerative colitis or other gastrointestinal condition associated with increased risk of perforation; history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 4 weeks prior to registration * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * No patients with a history of autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease modifying agents, corticosteroids \> 10 mg/day, or immunosuppressive drugs) with the following exceptions: * Replacement therapy (e.g., thyroxine, insulin, physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed * Brief (\<7 days) use of systemic corticosteroids is allowed when use is considered standard of care * Patients with vitiligo, psoriasis, type 1 diabetes mellitus, hypothyroidism, or resolved childhood asthma/atopy will not be excluded * Patients requiring intermittent use of bronchodilators, inhaled steroids, or local steroid injections will not be excluded * Patients with hypothyroidism that is stable with hormone replacement or Sjögren's syndrome will not be excluded • Chronic concomitant treatment with strong CYP3A4 inducers is not allowed. Patients must discontinue the drug 14 days prior to the start of study treatment

Interventions: BIOLOGICAL: Pembrolizumab, DRUG: Tivozanib, PROCEDURE: Biospecimen Collection, PROCEDURE: MRI, PROCEDURE: Computed Tomography, PROCEDURE: Biopsy, OTHER: Questionnaire Administration

Conditions: Clear Cell Renal Cell Carcinoma, Renal Cell Carcinoma (RCC), Stage II Renal Pelvis Cancer AJCC v8, Stage III Renal Pelvis Cancer AJCC v8

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Show 373 locations

Study Locations

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Location	Contacts
AMG Crystal Lake - Oncology Crystal Lake, Illinois	Site Public Contact - (advocateresearch@advocate.com)
AMG Libertyville - Oncology Libertyville, Illinois	Site Public Contact - (advocateresearch@advocatehealth.com)
Abbott-Northwestern Hospital Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Advocate Christ Medical Center Oak Lawn, Illinois
Advocate Good Samaritan Hospital Downers Grove, Illinois	Site Public Contact - (Barbara.barhamand@advocatehealth.com)
Advocate Good Shepherd Hospital Barrington, Illinois
Advocate High Tech Medical Park Palos Heights, Illinois	Site Public Contact - (ncorp@aah.org)
Advocate Illinois Masonic Medical Center Chicago, Illinois
Advocate Lutheran General Hospital Park Ridge, Illinois
Advocate Outpatient Center - Aurora Aurora, Illinois	Site Public Contact - (ncorp@aah.org)
Advocate Outpatient Center - Oak Lawn Oak Lawn, Illinois	Site Public Contact - (ncorp@aah.org)
Advocate Sherman Hospital Elgin, Illinois
Advocate South Suburban Hospital Hazel Crest, Illinois
Aultman Health Foundation Canton, Ohio	Site Public Contact - (ClinicalReserachDept@aultman.com)
Aurora Bay Area Medical Group-Marinette Marinette, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora BayCare Medical Center Green Bay, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Grafton Grafton, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Kenosha South Kenosha, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Milwaukee Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Racine Racine, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Southern Lakes VLCC Burlington, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Health Care Germantown Health Center Germantown, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Medical Center in Summit Summit, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Saint Luke's Medical Center Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Saint Luke's South Shore Cudahy, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Sinai Medical Center Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora West Allis Medical Center West Allis, Wisconsin	Site Public Contact - (ncorp@aurora.org)
BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri
Banner University Medical Center - Tucson Tucson, Arizona	Site Public Contact - (UACC-IIT@uacc.arizona.edu)
Baptist Cancer Center-Grenada Grenada, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Health Louisville Louisville, Kentucky	Site Public Contact - (Cbcresearch@bhsi.com)
Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Oxford Oxford, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Union County New Albany, Mississippi	Site Public Contact - (BCCclintrials@bmhcc.org)
Beebe Health Campus Rehoboth Beach, Delaware	Site Public Contact - (research@beebehealthcare.org)
Beebe South Coastal Health Campus Millville, Delaware	Site Public Contact - (research@beebehealthcare.org)
Benefis Sletten Cancer Institute Great Falls, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Billings Clinic Cancer Center Billings, Montana	Site Public Contact - (research@billingsclinic.org)
Bon Secours Memorial Regional Medical Center Mechanicsville, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Richmond Community Hospital Richmond, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Saint Francis Medical Center Midlothian, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Saint Mary's Hospital Richmond, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bozeman Health Deaconess Hospital Bozeman, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Bronson Battle Creek Battle Creek, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Bronson Methodist Hospital Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
California Pacific Medical Center-Pacific Campus San Francisco, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Camden Clark Medical Center Parkersburg, West Virginia	Site Public Contact - (cancertrialsinfo@hsc.wvu.edu)
Cancer Care Center of O'Fallon O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Care and Hematology-Fort Collins Fort Collins, Colorado	Site Public Contact - (protocols@AllianceNCTN.org)
Cancer Center at Saint Joseph's Phoenix, Arizona	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Cancer Centers of Southwest Oklahoma Research Lawton, Oklahoma
Cancer Hematology Centers - Flint Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan	Site Public Contact - (connie.szczepanek@crcwm.org)
Case Western Reserve University Cleveland, Ohio	Site Public Contact - (CTUReferral@UHhospitals.org)
Cedars Sinai Medical Center Los Angeles, California
City of Hope Antelope Valley Lancaster, California	Site Public Contact - (becomingapatient@coh.org)
City of Hope Comprehensive Cancer Center Duarte, California	Site Public Contact - (becomingapatient@coh.org)
City of Hope South Bay Torrance, California
City of Hope Upland Upland, California	Site Public Contact - (becomingapatient@coh.org)
City of Hope at Irvine Lennar Irvine, California
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud, Minnesota	Site Public Contact - (coborncancercenter@centracare.com)
Community Hospital of Anaconda Anaconda, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Community Medical Center Missoula, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Community Medical Center Missoula, Montana	Site Public Contact - (HemonCCTrials@geisinger.edu)
Condell Memorial Hospital Libertyville, Illinois	Site Public Contact - (advocateresearch@advocatehealth.com)
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Lakeland Hospitals - Niles Hospital Niles, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Reed City Hospital Reed City, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Crossroads Cancer Center Effingham, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Dana Farber-Merrimack Valley Methuen, Massachusetts
Dana-Farber Cancer Institute Boston, Massachusetts
Dana-Farber Cancer Institute at Foxborough Foxborough, Massachusetts
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Milford, Massachusetts
Dana-Farber/Brigham and Women's Cancer Center at South Shore South Weymouth, Massachusetts
Dartmouth Cancer Center - North Saint Johnsbury, Vermont
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon, New Hampshire	Site Public Contact - (cancer.research.nurse@dartmouth.edu)
Decatur Memorial Hospital Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Divine Providence Hospital Williamsport, Pennsylvania	Site Public Contact - (protocols@AllianceNCTN.org)
Drexel Town Square Health Center Oak Creek, Wisconsin
Duke Cancer Center Cary Cary, North Carolina	Site Public Contact - (NCTNStudyTeam@dm.duke.edu)
Duke Cancer Center Raleigh Raleigh, North Carolina	Site Public Contact - (NCTNStudyTeam@dm.duke.edu)
Duke University Medical Center Durham, North Carolina
Duluth Clinic Ashland Ashland, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Edward Hospital/Cancer Center Naperville, Illinois
Edward Hospital/Cancer Center?Plainfield Plainfield, Illinois	Site Public Contact - (Cancerresearch@edward.org)
Elmhurst Memorial Hospital Elmhurst, Illinois	Site Public Contact - (Jrohde@emhc.org)
Emory Johns Creek Hospital Johns Creek, Georgia	Site Public Contact - (m.lisa.hwang@emory.edu)
Emory Saint Joseph's Hospital Atlanta, Georgia
Emory University Hospital Midtown Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute Atlanta, Georgia
Essentia Health - Deer River Clinic Deer River, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Hibbing Clinic Hibbing, Minnesota
Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Sandstone Sandstone, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Virginia Clinic Virginia, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Fairview Southdale Hospital Edina, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst, North Carolina	Site Public Contact - (jcwilliams@firsthealth.org)
Froedtert Menomonee Falls Hospital Menomonee Falls, Wisconsin
Froedtert West Bend Hospital/Kraemer Cancer Center West Bend, Wisconsin
Geisinger Cancer Center Dickson City Dickson City, Pennsylvania	Site Public Contact - (hemoncctrials@geisinger.edu)
Geisinger Medical Center Danville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Genesee Hematology Oncology PC Flint, Michigan
Genesys Hurley Cancer Institute Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
George Washington University Medical Center Washington D.C., District of Columbia
Glens Falls Hospital Glens Falls, New York
Grady Health System Atlanta, Georgia
Gundersen Lutheran Medical Center La Crosse, Wisconsin	Site Public Contact - (cancerctr@gundersenhealth.org)
Hackensack University Medical Center Hackensack, New Jersey
Hartford HealthCare - Saint Vincent's Medical Center Bridgeport, Connecticut
Hartford Healthcare - Fairfield Fairfield, Connecticut	Site Public Contact - (CancerResearchSupport@hhchealth.org)
Hartford Hospital Hartford, Connecticut
Helen F Graham Cancer Center Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Hematology Oncology Associates of CNY at Camillus Camillus, New York
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse, New York
Hennepin County Medical Center Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Houston Methodist Cypress Hospital Cypress, Texas	Site Public Contact - (irb@houstonmethodist.org)
Houston Methodist Hospital Houston, Texas
Houston Methodist Saint John Hospital Nassau Bay, Texas	Site Public Contact - (protocols@AllianceNCTN.org)
Houston Methodist San Jacinto Hospital Baytown, Texas	Site Public Contact - (protocols@AllianceNCTN.org)
Houston Methodist Sugar Land Hospital Sugar Land, Texas
Houston Methodist The Woodlands Hospital The Woodlands, Texas	Site Public Contact - (hmthewoodlands@houstonmethodist.org)
Houston Methodist West Hospital Houston, Texas
IU Health North Hospital Carmel, Indiana	Site Public Contact - (iutrials@iu.edu)
IU Health West Hospital Avon, Indiana	Site Public Contact - (iutrials@iu.edu)
Illinois CancerCare - Washington Washington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Bloomington Bloomington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Canton Canton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Carthage Carthage, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Dixon Dixon, Illinois
Illinois CancerCare-Eureka Eureka, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Galesburg Galesburg, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Macomb Macomb, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Pekin Pekin, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peoria Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peru Peru, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Princeton Princeton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana	Site Public Contact - (iutrials@iu.edu)
Indu and Raj Soin Medical Center Beavercreek, Ohio
Jefferson Cherry Hill Hospital Cherry Hill, New Jersey	Site Public Contact - (ONCTrialNow@jefferson.edu)
Jefferson Torresdale Hospital Philadelphia, Pennsylvania	Site Public Contact - (ONCTrialNow@jefferson.edu)
Kettering Medical Center Kettering, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Lafayette Family Cancer Center-EMMC Brewer, Maine
Lahey Hospital and Medical Center Burlington, Massachusetts	Site Public Contact - (lhmc-cancer-clinical-trials@lahey.org)
Lahey Medical Center-Peabody Peabody, Massachusetts	Site Public Contact - (lhmc-cancer-clinical-trials@lahey.org)
Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Hazleton Hazleton, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Logan Health Medical Center Kalispell, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Los Angeles General Medical Center Los Angeles, California	Site Public Contact - (uscnorrisinfo@med.usc.edu)
Mary Greeley Medical Center Ames, Iowa
McFarland Clinic - Ames Ames, Iowa	Site Public Contact - (ksoder@mcfarlandclinic.com)
McFarland Clinic - Boone Boone, Iowa
McFarland Clinic - Jefferson Jefferson, Iowa
McFarland Clinic - Marshalltown Marshalltown, Iowa
McFarland Clinic - Trinity Cancer Center Fort Dodge, Iowa
Medical Center of the Rockies Loveland, Colorado
Medical College of Wisconsin Milwaukee, Wisconsin
Medical Oncology Hematology Consultants PA Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Medical University of South Carolina Charleston, South Carolina	Site Public Contact - (hcc-clinical-trials@musc.edu)
Medstar Washington Hospital Center Washington D.C., District of Columbia
Memorial Hospital East Shiloh, Illinois	Site Public Contact - (dschwab@wustl.edu)
Memorial Hospital North Colorado Springs, Colorado
Memorial Medical Center Modesto, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Memorial Sloan Kettering Basking Ridge Basking Ridge, New Jersey
Memorial Sloan Kettering Bergen Montvale, New Jersey
Memorial Sloan Kettering Cancer Center New York, New York
Memorial Sloan Kettering Commack Commack, New York
Memorial Sloan Kettering Monmouth Middletown, New Jersey
Memorial Sloan Kettering Nassau Uniondale, New York
Memorial Sloan Kettering Westchester Harrison, New York
Mercy Hospital Cedar Rapids, Iowa
Mercy Hospital Cedar Rapids, Iowa	Site Public Contact - (mmcorc@healthpartners.com)
Mercy Hospital Saint Louis St Louis, Missouri
Mercy Hospital South St Louis, Missouri	Site Public Contact - (Danielle.Werle@mercy.net)
Methodist Willowbrook Hospital Houston, Texas	Site Public Contact - (protocols@AllianceNCTN.org)
Miami Cancer Institute Miami, Florida
Midstate Medical Center Meriden, Connecticut
Mills Health Center San Mateo, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Minnesota Oncology - Burnsville Burnsville, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Missouri Baptist Medical Center St Louis, Missouri
Missouri Baptist Sullivan Hospital Sullivan, Missouri
Monmouth Medical Center Long Branch, New Jersey	Site Public Contact - (mary.danish@rwjbh.org)
Montefiore Medical Center-Einstein Campus The Bronx, New York	Site Public Contact - (eskwak@montefiore.org)
Morristown Medical Center Morristown, New Jersey
Mount Sinai Chelsea New York, New York
Mount Sinai Hospital New York, New York
Munson Medical Center Traverse City, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro, Arkansas	Site Public Contact - (Emily.Carvell@bmhcc.org)
Northwestern Medicine Cancer Center Delnor Geneva, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Cancer Center Kishwaukee DeKalb, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Glenview Outpatient Center Glenview, Illinois
Northwestern Medicine Grayslake Outpatient Center Grayslake, Illinois
Northwestern Medicine Lake Forest Hospital Lake Forest, Illinois	Site Public Contact - (cancertrials@northwestern.edu)
Northwestern Medicine Oak Brook Oak Brook, Illinois	Site Public Contact - (nctnprogram_rhlccc@northwestern.edu)
Northwestern Medicine Orland Park Orland Park, Illinois	Site Public Contact - (nctnprogram_rhlccc@northwestern.edu)
Northwestern University Chicago, Illinois	Site Public Contact - (cancer@northwestern.edu)
OSF Saint Francis Hospital and Medical Group Escanaba, Michigan	Site Public Contact - (WI_research_admin@hshs.org)
Ochsner Medical Center Jefferson New Orleans, Louisiana	Site Public Contact - (Elisemarie.curry@ochsner.org)
Ohio State University Comprehensive Cancer Center Columbus, Ohio	Site Public Contact - (Jamesline@osumc.edu)
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa
Oregon Health and Science University Portland, Oregon	Site Public Contact - (trials@ohsu.edu)
Overlook Hospital Summit, New Jersey
Palo Alto Medical Foundation Health Care Palo Alto, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Palo Alto Medical Foundation-Santa Cruz Santa Cruz, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Palo Alto Medical Foundation-Sunnyvale Sunnyvale, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Parkland Health Center - Farmington Farmington, Missouri
Pocono Medical Center East Stroudsburg, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Poudre Valley Hospital Fort Collins, Colorado
Prisma Health Cancer Institute - Butternut Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Easley Easley, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Eastside Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Faris Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Greer Greer, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Seneca Seneca, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
ProHealth D N Greenwald Center Mukwonago, Wisconsin	Site Public Contact - (research.institute@phci.org)
ProHealth Oconomowoc Memorial Hospital Oconomowoc, Wisconsin
ProHealth Waukesha Memorial Hospital Waukesha, Wisconsin
Providence Newberg Medical Center Newberg, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Portland Medical Center Portland, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Saint Vincent Medical Center Portland, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Willamette Falls Medical Center Oregon City, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Regions Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Robert Wood Johnson University Hospital Somerset Somerville, New Jersey	Site Public Contact - (Siby.Varughese@rwjbh.org)
Roswell Park Cancer Institute Buffalo, New York	Site Public Contact - (askroswell@roswellpark.org)
Rush MD Anderson Cancer Center Chicago, Illinois	Site Public Contact - (Cancer_Studies@rush.edu)
Rush-Copley Healthcare Center Yorkville, Illinois	Site Public Contact - (Cancer.Research@rushcopley.com)
Rush-Copley Medical Center Aurora, Illinois	Site Public Contact - (RCMC_Cancer_Research@rush.edu)
Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey
Rutgers New Jersey Medical School Newark, New Jersey
SIH Cancer Institute Carterville, Illinois	Site Public Contact - (clinical.research@sih.net)
Saint Francis Medical Center Cape Girardeau, Missouri	Site Public Contact - (sfmc@sfmc.net)
Saint Francis Regional Medical Center Shakopee, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Saint Luke's Cancer Institute - Boise Boise, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Fruitland Fruitland, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Meridian Meridian, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Nampa Nampa, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin	Site Public Contact - (WI_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls, Wisconsin	Site Public Contact - (WI_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri
Sanford Bismarck Medical Center Bismarck, North Dakota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford Broadway Medical Center Fargo, North Dakota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota	Site Public Contact - (OncologyClinicTrialsSF@sanfordhealth.org)
Sanford Joe Lueken Cancer Center Bemidji, Minnesota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford Roger Maris Cancer Center Fargo, North Dakota	Site Public Contact - (OncologyClinicalTrialsFargo@sanfordhealth.org)
Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota	Site Public Contact - (OncologyClinicalTrialsSF@SanfordHealth.org)
Sheboygan Physicians Group Sheboygan, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Sidney Kimmel Cancer Center Washington Township Sewell, New Jersey	Site Public Contact - (ONCTrialNow@jefferson.edu)
Sidney and Lois Eskenazi Hospital Indianapolis, Indiana	Site Public Contact - (iutrials@iu.edu)
Siteman Cancer Center at Christian Hospital St Louis, Missouri	Site Public Contact - (info@siteman.wustl.edu)
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters, Missouri	Site Public Contact - (info@siteman.wustl.edu)
Siteman Cancer Center at West County Hospital Creve Coeur, Missouri	Site Public Contact - (info@siteman.wustl.edu)
Siteman Cancer Center-South County St Louis, Missouri	Site Public Contact - (info@siteman.wustl.edu)
Smilow Cancer Hospital Care Center - Guilford Guilford, Connecticut	Site Public Contact - (canceranswers@yale.edu)
Smilow Cancer Hospital Care Center - Waterford Waterford, Connecticut	Site Public Contact - (canceranswers@yale.edu)
Smilow Cancer Hospital Care Center - Westerly Westerly, Rhode Island	Site Public Contact - (canceranswers@yale.edu)
Smilow Cancer Hospital Care Center at Glastonbury Glastonbury, Connecticut
Smilow Cancer Hospital Care Center at Greenwich Greenwich, Connecticut	Site Public Contact - (canceranswers@yale.edu)
Smilow Cancer Hospital Care Center at Long Ridge Stamford, Connecticut	Site Public Contact - (canceranswers@yale.edu)
Smilow Cancer Hospital Care Center at Saint Francis Hartford, Connecticut
Smilow Cancer Hospital Care Center-Fairfield Fairfield, Connecticut	Site Public Contact - (canceranswers@yale.edu)
Smilow Cancer Hospital Care Center-Trumbull Trumbull, Connecticut	Site Public Contact - (canceranswers@yale.edu)
Smilow Cancer Hospital-Derby Care Center Derby, Connecticut	Site Public Contact - (canceranswers@yale.edu)
Smilow Cancer Hospital-Torrington Care Center Torrington, Connecticut	Site Public Contact - (canceranswers@yale.edu)
Smilow Cancer Hospital-Waterbury Care Center Waterbury, Connecticut	Site Public Contact - (canceranswers@yale.edu)
Southern Illinois University School of Medicine Springfield, Illinois
Springfield Clinic Springfield, Illinois
Springfield Memorial Hospital Springfield, Illinois	Site Public Contact - (pallante.beth@mhsil.com)
Stamford Hospital/Bennett Cancer Center Stamford, Connecticut
Sutter Auburn Faith Hospital Auburn, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Sutter Medical Center Sacramento Sacramento, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Sutter Roseville Medical Center Roseville, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Sutter Solano Medical Center/Cancer Center Vallejo, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
The Cancer Institute of New Jersey Hamilton Hamilton, New Jersey
The Don and Sybil Harrington Cancer Center Amarillo, Texas	Site Public Contact - (Gina.Cravey@bsahs.org)
The Hospital of Central Connecticut New Britain, Connecticut
The James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky
ThedaCare Regional Cancer Center Appleton, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
Thomas Jefferson University Hospital Philadelphia, Pennsylvania	Site Public Contact - (ONCTrialNow@jefferson.edu)
Tidelands Georgetown Memorial Hospital Georgetown, South Carolina	Site Public Contact - (broe@tidelandshealth.org)
Torrance Memorial Physician Network - Cancer Care Torrance, California	Site Public Contact - (courtney.steeneken@tmphysicians.com)
Tower Cancer Research Foundation Beverly Hills, California	Site Public Contact - (towercancerresearch@toweroncology.com)
Trinity Health Grand Rapids Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Muskegon Hospital Muskegon, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California	Site Public Contact - (ucstudy@uci.edu)
UC San Diego Medical Center - Hillcrest San Diego, California	Site Public Contact - (rhabbaba@health.ucsd.edu)
UC San Diego Moores Cancer Center La Jolla, California	Site Public Contact - (cancercto@ucsd.edu)
UCHealth - Cherry Creek Denver, Colorado	Site Public Contact - (protocols@AllianceNCTN.org)
UCHealth Greeley Hospital Greeley, Colorado	Site Public Contact - (protocols@AllianceNCTN.org)
UCHealth Highlands Ranch Hospital Highlands Ranch, Colorado
UCHealth Lone Tree Health Center Lone Tree, Colorado	Site Public Contact - (protocols@AllianceNCTN.org)
UCHealth Memorial Hospital Central Colorado Springs, Colorado
UCHealth University of Colorado Hospital Aurora, Colorado
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine, California	Site Public Contact - (ucstudy@uci.edu)
UF Health Cancer Institute - Gainesville Gainesville, Florida	Site Public Contact - (cancer-center@ufl.edu)
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor, Ohio	Site Public Contact - (CTUReferral@UHhospitals.org)
UH Seidman Cancer Center at UH Avon Health Center Avon, Ohio
UHHS-Chagrin Highlands Medical Center Beachwood, Ohio	Site Public Contact - (CTUReferral@UHhospitals.org)
UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina	Site Public Contact - (cancerclinicaltrials@med.unc.edu)
UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg, Pennsylvania
UPMC Hillman Cancer Center - Monroeville Monroeville, Pennsylvania	Site Public Contact - (ClinicalResearchServices@upmc.edu)
UPMC Hillman Cancer Center Erie Erie, Pennsylvania	Site Public Contact - (ClinicalResearchServices@upmc.edu)
UPMC Hillman Cancer Center at Butler Health System Butler, Pennsylvania	Site Public Contact - (haneydl@upmc.edu)
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg, Pennsylvania	Site Public Contact - (haneydl@upmc.edu)
UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg, Pennsylvania	Site Public Contact - (klitchfield@PINNACLEHEALTH.org)
UPMC Western Maryland Cumberland, Maryland
UPMC-Heritage Valley Health System Beaver Beaver, Pennsylvania	Site Public Contact - (haneydl@upmc.edu)
UPMC-Johnstown/John P. Murtha Regional Cancer Center Johnstown, Pennsylvania
UPMC-Passavant Hospital Pittsburgh, Pennsylvania
UPMC-Saint Clair Hospital Cancer Center Pittsburgh, Pennsylvania
USC / Norris Comprehensive Cancer Center Los Angeles, California
USC Norris Oncology/Hematology-Newport Beach Newport Beach, California
UT Southwestern Clinical Center at Richardson/Plano Richardson, Texas	Site Public Contact - (Suzanne.cole@utsouthwestern.edu)
UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas	Site Public Contact - (canceranswerline@UTSouthwestern.edu)
UW Cancer Center at ProHealth Care Waukesha, Wisconsin	Site Public Contact - (Chanda.miller@phci.org)
United Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
United Hospital Center Bridgeport, West Virginia	Site Public Contact - (cancertrialsinfo@hsc.wvu.edu)
University of Arizona Cancer Center-North Campus Tucson, Arizona	Site Public Contact - (UACC-IIT@uacc.arizona.edu)
University of Arkansas for Medical Sciences Little Rock, Arkansas
University of California Davis Comprehensive Cancer Center Sacramento, California
University of Illinois Chicago, Illinois
University of Michigan Health - Sparrow Lansing Lansing, Michigan	Site Public Contact - (harsha.trivedi@umhsparrow.org)
University of Michigan Health - West Wyoming, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
University of Mississippi Medical Center Jackson, Mississippi
University of New Mexico Cancer Center Albuquerque, New Mexico
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma	Site Public Contact - (ou-clinical-trials@ouhsc.edu)
University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania
University of Vermont Medical Center Burlington, Vermont	Site Public Contact - (rpo@uvm.edu)
University of Vermont and State Agricultural College Burlington, Vermont	Site Public Contact - (rpo@uvm.edu)
UofL Health Medical Center Northeast Louisville, Kentucky	Site Public Contact - (ctoinfo@louisville.edu)
VCU Massey Cancer Center at Stony Point Richmond, Virginia	Site Public Contact - (ctoclinops@vcu.edu)
VCU Massey Comprehensive Cancer Center Richmond, Virginia	Site Public Contact - (CTOclinops@vcu.edu)
Vanderbilt University/Ingram Cancer Center Nashville, Tennessee
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers, Wisconsin	Site Public Contact - (ncorp@aurora.org)
WVUH-Berkely Medical Center Martinsburg, West Virginia	Site Public Contact - (cancertrialsinfo@hsc.wvu.edu)
Washington University School of Medicine St Louis, Missouri	Site Public Contact - (info@siteman.wustl.edu)
West Michigan Cancer Center Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
West Virginia University Charleston Division Charleston, West Virginia
West Virginia University Healthcare Morgantown, West Virginia	Site Public Contact - (cancertrialsinfo@hsc.wvu.edu)
Yale University New Haven, Connecticut	Site Public Contact - (canceranswers@yale.edu)
Yale-New Haven Hospital North Haven Medical Center North Haven, Connecticut

PAS 1ml Magtrace® for Sentinel Lymph Node Biopsy in Breast Cancer Patients (MAGProm)

Contact(s):

Vicky Crawford - vcrawford@endomag.com

Principal Investigator:

System ID: NCT06610539

Show full eligibility criteria

Conditions: Breast Cancer

Keywords: Magtrace, Sentinel Lymph Node Biopsy

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Study Locations

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Location	Contacts
VCU Massey Comprehensive Cancer Center Richmond, Virginia

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

Contact(s):

ctrrecruit@vcu.edu

Principal Investigator:

System ID: NCT06124157

Show full eligibility criteria

Inclusion Criteria:

* Patients must be \> 365 days and \< 18 years (for AIEOP-BFM), \> 365 days and \< 22 years (for Children's Oncology Group \[COG\]) and \> 365 days and \< 46 years (for ALLTogether sites) at the time of enrollment * Newly-diagnosed Ph+ or ABL-class Ph-like B-ALL. Leukemic blasts must express CD19. ABL-class fusions are defined as rearrangements involving the following genes predicted to be sensitive to imatinib and/or dasatinib: ABL1, ABL2, CSF1R, and PDGFRB * Evidence of BCR::ABL1 should be documented by a clinically-validated assay prior to study entry on day 15 from the first dose of vinCRIStine during Induction therapy. ABL-class Ph-like B-ALL gene rearrangements should be documented by a clinically-validated assay and enrolled on study by day 1 of Blinatumomab Block 1. Accepted methods of detection include fluorescence in situ hybridization (FISH) using break-apart of colocalization signal probes, singleplex or multiplex reverse-transcription polymerase chain reaction (RT-PCR), whole-transcriptome or panel-based ribonucleic acid (RNA) sequencing (e.g., Hematologic Cancer Fusion Analysis, TruSight RNA Pan-Cancer Panel or equivalent). Confirmation of 5' fusion partner genes is not required for study enrollment * Patients with Ph+ B-ALL must have previously started Induction therapy, which includes vinCRIStine, a corticosteroid, pegaspargase or calaspargase pegol, with or without anthracycline, and/or other standard cytotoxic chemotherapy * Patients with Ph+ B-ALL have not received more than 14 days of systemic Induction therapy beginning with the first Induction dose of vinCRIStine * Patients with ABL-class Ph-like B-ALL must have previously completed 4 or 5 weeks of multiagent Induction chemotherapy (Induction 1A) * Patients may have started either imatinib or dasatinib prior to study entry but should have received no more than 14 days of TKI for Ph+ B-ALL or no more than 35 days of TKI for ABL-class Ph-like B-ALL * Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of ≤ 2 or Karnofsky and Lansky performance scores ≥ 50%. Use Karnofsky for patients \> 16 years of age and Lansky for patients ≤ 16 years of age * For pediatric patients (age 1-17 years): a glomerular filtration rate (GFR) ≥ 50 mL/min/1.73 m\^2, as determined by one of the following methods (must be performed within 7 days prior to enrollment unless otherwise indicated): * Estimated GFR (eGFR) ≥ 50 mL/min/1.73 m2 * Measured GFR ≥ 50 mL/min/1.73 m\^2 (any age). If measured GFR is used, it must be performed using direct measurement with a nuclear blood sampling method or small molecule clearance method (iothalamate or other molecule per institutional standard * For adult patients (age 18 years or older): Creatinine clearance ≥ 30 mL/min, as estimated by the Cockcroft and Gault formula. The creatinine value used in the calculation must have been obtained within 28 days prior to registration. Estimated creatinine clearance is based on body weight * Direct bilirubin \< 2.0 mg/dL (34.2 micromoles/L) (must be performed within 7 days prior to enrollment unless otherwise indicated) * Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 10 x upper limit of normal (ULN) (must be performed within 7 days prior to enrollment unless otherwise indicated) * \* Shortening fraction of ≥ 27% by echocardiogram (must be obtained within 21 days prior to enrollment and start of protocol therapy \[repeat if necessary\]) OR * Left Ventricular Ejection fraction of ≥ 50% by radionuclide angiogram or echocardiogram (must be obtained within 21 days prior to enrollment and start of protocol therapy \[repeat if necessary\]) AND * Corrected QT Interval, QTc \< 480mSec (must be obtained within 21 days prior to enrollment and start of protocol therapy \[repeat if necessary\]) * Note: Repeat echocardiogram and electrocardiogram are not required if they were performed at or after initial ALL diagnosis before study enrollment

Exclusion Criteria:

* Known history of chronic myeloid leukemia (CML) * ABL-class Ph-like B-ALL who are CNS2 or CNS3 at end of Induction phase * ALL developing after a previous cancer treated with cytotoxic chemotherapy * Active, uncontrolled infection or active systemic illness that requires ongoing vasopressor support or mechanical ventilation * Down syndrome (trisomy 21) * Pregnancy and breast feeding * Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. A negative pregnancy test is required for female patients of childbearing potential within 7 days prior to enrollment * Lactating females who plan to breastfeed their infants * Sexually active male and female patients of reproductive potential who have not agreed to use an effective contraception method for the duration of treatment according to protocol * NOTE: Patients who could become pregnant or could father a child must use effective contraception during protocol treatment and for 30 days after the last dose of dasatinib or 14 days after the last dose of imatinib dose or per institutional standard of care for multiagent chemotherapy, whichever is longer * Prior treatment with TKIs before study entry with the exception of imatinib or dasatinib * Patients with congenital long QT syndrome, history of ventricular arrhythmias, or heart block * Patients with known Charcot-Marie-Tooth disease * Patients with significant central nervous system pathology that would preclude treatment with blinatumomab, including history of severe neurologic disorder or autoimmune disease with central nervous system (CNS) involvement * Note: Patients with a history of seizures that are well controlled on stable doses of anti-epileptic drugs are eligible. Patients with a history of cerebrovascular ischemia/hemorrhage with residual deficits are not eligible. Patients with a history of cerebrovascular ischemia/hemorrhage remain eligible provided all neurologic deficits have resolved * HIV-infected patients are eligible if on effective anti-retroviral therapy that does not interact with planned study agents and with undetectable viral load within 6 months of treatment * All patients and/or their parents or legal guardians must sign a written informed consent * All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Interventions: PROCEDURE: Biospecimen Collection, BIOLOGICAL: Blinatumomab, PROCEDURE: Bone Marrow Biopsy, DRUG: Calaspargase Pegol, DRUG: Cyclophosphamide, DRUG: Cytarabine, DRUG: Dasatinib, DRUG: Daunorubicin, DRUG: Doxorubicin, PROCEDURE: Echocardiography Test, DRUG: Imatinib, DRUG: Leucovorin, DRUG: Mercaptopurine, DRUG: Methotrexate, PROCEDURE: Multigated Acquisition Scan, DRUG: Pegaspargase, DRUG: Prednisolone, DRUG: Prednisone, RADIATION: Radiation Therapy, DRUG: Thioguanine, DRUG: Vincristine

Conditions: B Acute Lymphoblastic Leukemia

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Study Locations

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Location	Contacts
Advocate Children's Hospital-Oak Lawn Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge Park Ridge, Illinois	Site Public Contact - (helpdesk@childrensoncologygroup.org)
Albany Medical Center Albany, New York
Alfred I duPont Hospital for Children Wilmington, Delaware	Site Public Contact - (Allison.bruce@nemours.org)
Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Arkansas Children's Hospital Little Rock, Arkansas
Arnold Palmer Hospital for Children Orlando, Florida	Site Public Contact - (Jennifer.spinelli@orlandohealth.com)
Atrium Health Navicent Macon, Georgia	Site Public Contact - (andrew.weatherall@atriumhealth.org)
Augusta University Medical Center Augusta, Georgia	Site Public Contact - (ga_cares@augusta.edu)
BI-LO Charities Children's Cancer Center Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
British Columbia Children's Hospital Vancouver, British Columbia
Bronson Methodist Hospital Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
C S Mott Children's Hospital Ann Arbor, Michigan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL) Québec,	Site Public Contact - (rechclinique@crchudequebec.ulaval.ca)
Carolinas Medical Center/Levine Cancer Institute Charlotte, North Carolina
Centre Hospitalier Universitaire Sainte-Justine Montreal, Quebec	Site Public Contact - (yvan.samson@umontreal.ca)
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont Sherbrooke, Quebec	Site Public Contact - (crcinformation.chus@ssss.gouv.qc.ca)
Children's Hospital Colorado Aurora, Colorado	Site Public Contact - (josh.b.gordon@nsmtp.kp.org)
Children's Hospital Los Angeles Los Angeles, California
Children's Hospital Medical Center Of Akron Akron, Ohio
Children's Hospital and Medical Center of Omaha Omaha, Nebraska
Children's Hospital of Alabama Birmingham, Alabama	Site Public Contact - (oncologyresearch@peds.uab.edu)
Children's Hospital of Michigan Detroit, Michigan	Site Public Contact - (helpdesk@childrensoncologygroup.org)
Children's Hospital of Orange County Orange, California	Site Public Contact - (oncresearch@choc.org)
Children's Hospital of Philadelphia Philadelphia, Pennsylvania	Site Public Contact - (CancerTrials@email.chop.edu)
Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania	Site Public Contact - (jean.tersak@chp.edu)
Children's Hospital of San Antonio San Antonio, Texas	Site Public Contact - (bridget.medina@christushealth.org)
Children's Hospital of Wisconsin Milwaukee, Wisconsin	Site Public Contact - (MACCCTO@mcw.edu)
Children's Hospital of the King's Daughters Norfolk, Virginia	Site Public Contact - (CCBDCresearch@chkd.org)
Children's Mercy Hospitals and Clinics Kansas City, Missouri	Site Public Contact - (COGResearchGroup@cmh.edu)
Children's National Medical Center Washington D.C., District of Columbia	Site Public Contact - (OncCRC_OnCall@childrensnational.org)
Cincinnati Children's Hospital Medical Center Cincinnati, Ohio	Site Public Contact - (cancer@cchmc.org)
Cook Children's Medical Center Fort Worth, Texas	Site Public Contact - (CookChildrensResearch@cookchildrens.org)
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Covenant Children's Hospital Lubbock, Texas	Site Public Contact - (mbisbee@providence.org)
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon, New Hampshire	Site Public Contact - (cancer.research.nurse@dartmouth.edu)
Dayton Children's Hospital Dayton, Ohio
Dell Children's Medical Center of Central Texas Austin, Texas	Site Public Contact - (TXAUS-DL-SFCHemonc.research@ascension.org)
Driscoll Children's Hospital Corpus Christi, Texas	Site Public Contact - (Crystal.DeLosSantos@dchstx.org)
Duke University Medical Center Durham, North Carolina
East Tennessee Childrens Hospital Knoxville, Tennessee
El Paso Children's Hospital El Paso, Texas	Site Public Contact - (ranjan.bista@ttuhsc.edu)
Golisano Children's Hospital of Southwest Florida Fort Myers, Florida	Site Public Contact - (molly.arnstrom@leehealth.org)
Hospital for Sick Children Toronto, Ontario	Site Public Contact - (ask.CRS@sickkids.ca)
IWK Health Centre Halifax, Nova Scotia	Site Public Contact - (Research@iwk.nshealth.ca)
Inova Fairfax Hospital Falls Church, Virginia	Site Public Contact - (Stephanie.VanBebber@inova.org)
Johns Hopkins All Children's Hospital St. Petersburg, Florida	Site Public Contact - (Ashley.Repp@jhmi.edu)
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland	Site Public Contact - (jhcccro@jhmi.edu)
Kaiser Permanente-Oakland Oakland, California	Site Public Contact - (Kpoct@kp.org)
Kapiolani Medical Center for Women and Children Honolulu, Hawaii
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York	Site Public Contact - (CancerTrials@nyulangone.org)
Loma Linda University Medical Center Loma Linda, California
Lucile Packard Children's Hospital Stanford University Palo Alto, California	Site Public Contact - (ccto-office@stanford.edu)
Lurie Children's Hospital-Chicago Chicago, Illinois
Maine Children's Cancer Program Scarborough, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
Mary Bridge Children's Hospital and Health Center Tacoma, Washington	Site Public Contact - (research@multicare.org)
Mayo Clinic in Rochester Rochester, Minnesota
McMaster Children's Hospital at Hamilton Health Sciences Hamilton, Ontario
MedStar Georgetown University Hospital Washington D.C., District of Columbia
Medical City Dallas Hospital Dallas, Texas
Memorial Health University Medical Center Savannah, Georgia	Site Public Contact - (Lorraine.OHara@hcahealthcare.com)
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood, Florida	Site Public Contact - (OHR@mhs.net)
Memorial Sloan Kettering Cancer Center New York, New York
Methodist Children's Hospital of South Texas San Antonio, Texas	Site Public Contact - (Vinod.GidvaniDiaz@hcahealthcare.com)
Miller Children's and Women's Hospital Long Beach Long Beach, California
Mission Hospital Asheville, North Carolina	Site Public Contact - (NCDV.ResearchRegulatory@HCAHealthcare.com)
Morristown Medical Center Morristown, New Jersey
NYU Langone Hospital - Long Island Mineola, New York	Site Public Contact - (cancertrials@nyulangone.org)
Nemours Children's Clinic - Pensacola Pensacola, Florida	Site Public Contact - (helpdesk@childrensoncologygroup.org)
Nemours Children's Clinic-Jacksonville Jacksonville, Florida	Site Public Contact - (Allison.bruce@nemours.org)
New York Medical College Valhalla, New York
Ochsner Medical Center Jefferson New Orleans, Louisiana	Site Public Contact - (Elisemarie.curry@ochsner.org)
Penn State Children's Hospital Hershey, Pennsylvania
Perth Children's Hospital Perth, Western Australia	Site Public Contact - (helpdesk@childrensoncologygroup.org)
Phoenix Childrens Hospital Phoenix, Arizona
Primary Children's Hospital Salt Lake City, Utah
Prisma Health Richland Hospital Columbia, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital Toledo, Ohio	Site Public Contact - (PCIOncResearch@promedica.org)
Providence Sacred Heart Medical Center and Children's Hospital Spokane, Washington	Site Public Contact - (HopeBeginsHere@providence.org)
Rady Children's Hospital - San Diego San Diego, California
Rainbow Babies and Childrens Hospital Cleveland, Ohio
Rhode Island Hospital Providence, Rhode Island
Riley Hospital for Children Indianapolis, Indiana
Roswell Park Cancer Institute Buffalo, New York	Site Public Contact - (askroswell@roswellpark.org)
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital New Brunswick, New Jersey
Saint Christopher's Hospital for Children Philadelphia, Pennsylvania
Saint Joseph's Regional Medical Center Paterson, New Jersey	Site Public Contact - (HallL@sjhmc.org)
Saint Luke's Cancer Institute - Boise Boise, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin	Site Public Contact - (WI_research_admin@hshs.org)
Seattle Children's Hospital Seattle, Washington
Sinai Hospital of Baltimore Baltimore, Maryland
Southern Illinois University School of Medicine Springfield, Illinois
State University of New York Upstate Medical University Syracuse, New York
Stony Brook University Medical Center Stony Brook, New York
The Children's Hospital at TriStar Centennial Nashville, Tennessee
The Montreal Children's Hospital of the MUHC Montreal, Quebec	Site Public Contact - (info@thechildren.com)
UCSF Benioff Children's Hospital Oakland Oakland, California	Site Public Contact - (PedOncRschOAK@ucsf.edu)
UCSF Medical Center-Mission Bay San Francisco, California	Site Public Contact - (cancertrials@ucsf.edu)
UF Health Cancer Institute - Gainesville Gainesville, Florida	Site Public Contact - (cancer-center@ufl.edu)
UMC Cancer Center / UMC Health System Lubbock, Texas
UMass Memorial Medical Center - University Campus Worcester, Massachusetts	Site Public Contact - (cancer.research@umassmed.edu)
UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas	Site Public Contact - (canceranswerline@UTSouthwestern.edu)
University Pediatric Hospital San Juan,
University of Chicago Comprehensive Cancer Center Chicago, Illinois	Site Public Contact - (cancerclinicaltrials@bsd.uchicago.edu)
University of Illinois Chicago, Illinois
University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa
University of Kentucky/Markey Cancer Center Lexington, Kentucky
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida
University of Minnesota/Masonic Cancer Center Minneapolis, Minnesota
University of Mississippi Medical Center Jackson, Mississippi
University of Texas Health Science Center at San Antonio San Antonio, Texas	Site Public Contact - (phoresearchoffice@uthscsa.edu)
University of Vermont and State Agricultural College Burlington, Vermont	Site Public Contact - (rpo@uvm.edu)
University of Virginia Cancer Center Charlottesville, Virginia	Site Public Contact - (uvacancertrials@hscmail.mcc.virginia.edu)
University of Wisconsin Carbone Cancer Center - University Hospital Madison, Wisconsin	Site Public Contact - (clinicaltrials@cancer.wisc.edu)
VCU Massey Comprehensive Cancer Center Richmond, Virginia	Site Public Contact - (CTOclinops@vcu.edu)
Vanderbilt University/Ingram Cancer Center Nashville, Tennessee
Wake Forest University Health Sciences Winston-Salem, North Carolina
Walter Reed National Military Medical Center Bethesda, Maryland
Washington University School of Medicine St Louis, Missouri	Site Public Contact - (info@siteman.wustl.edu)
Yale University New Haven, Connecticut	Site Public Contact - (canceranswers@yale.edu)

The Vanguard Study: Testing a New Way to Screen for Cancer

Contact(s):

ctrrecruit@vcu.edu

Principal Investigator:

System ID: NCT06995898

Show full eligibility criteria

Interventions: PROCEDURE: Biospecimen Collection, DEVICE: Device Usage, OTHER: Electronic Health Record Review, PROCEDURE: Multi-Cancer Detection Test, PROCEDURE: Multi-Cancer Detection Test, OTHER: Questionnaire Administration

Conditions: Bladder Carcinoma, Breast Carcinoma, Colorectal Carcinoma, Esophageal Carcinoma, Gastric Carcinoma, Liver Carcinoma, Lung Carcinoma, Malignant Solid Neoplasm, Ovarian Carcinoma, Pancreatic Carcinoma, Prostate Carcinoma

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Study Locations

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Location	Contacts
Cancer Care and Hematology-Fort Collins Fort Collins, Colorado	Site Public Contact - (ctsucontact@westat.com)
Henry Ford Cancer Institute-Downriver Brownstown, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Hospital Detroit, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Medical Center Sterling Heights, Michigan	Site Public Contact - (ctsucontact@westat.com)
Henry Ford Medical Center - Detroit Northwest Detroit, Michigan	Site Public Contact - (kkeenan1@hfhs.org)
Henry Ford Medical Center - Livonia Livonia, Michigan	Site Public Contact - (kkeenan1@hfhs.org)
Henry Ford Medical Center - Plymouth Plymouth, Michigan	Site Public Contact - (kkeenan1@hfhs.org)
Henry Ford Medical Center - Royal Oak Royal Oak, Michigan	Site Public Contact - (kkeenan1@hfhs.org)
Henry Ford Medical Center - Troy Troy, Michigan	Site Public Contact - (kkeenan1@hfhs.org)
Henry Ford Medical Center-Columbus Novi, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Medical Center-Cottage Grosse Pointe Farms, Michigan
Henry Ford Medical Center-Fairlane Dearborn, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford West Bloomfield Hospital West Bloomfield, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Wyandotte Hospital Wyandotte, Michigan	Site Public Contact - (nhay@hfhs.org)
Inova Fair Oaks Hospital Fairfax, Virginia	Site Public Contact - (Stephanie.VanBebber@inova.org)
Inova Schar Cancer Institute Fairfax, Virginia	Site Public Contact - (Stephanie.VanBebber@inova.org)
Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii	Site Public Contact - (shelley.a.clark@kp.org)
Kaiser Permanente-Division of Research Pleasanton, California
Kaiser Permanente-Franklin Denver, Colorado	Site Public Contact - (KPCOIHRClinicalResearch@kp.org)
Kaiser Permanente-Lone Tree Lone Tree, Colorado	Site Public Contact - (KPCOIHRClinicalResearch@kp.org)
Kaiser Permanente-Rock Creek Lafayette, Colorado	Site Public Contact - (KPCOIHRClinicalResearch@kp.org)
Keefe Memorial Hospital Cheyenne Wells, Colorado	Site Public Contact - (cmillsap@keefemh.org)
Medical Center of the Rockies Loveland, Colorado
Poudre Valley Hospital Fort Collins, Colorado
Sentara Martha Jefferson Hospital Charlottesville, Virginia
Sentara Norfolk General Hospital Norfolk, Virginia
UCHealth Greeley Hospital Greeley, Colorado	Site Public Contact - (ctsucontact@westat.com)
UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina	Site Public Contact - (cancerclinicaltrials@med.unc.edu)
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma	Site Public Contact - (ou-clinical-trials@ouhsc.edu)
VCU Community Memorial Health Center South Hill, Virginia	Site Public Contact - (nemer.elmouallem@vcuhealth.org)
VCU Massey Cancer Center at Stony Point Richmond, Virginia	Site Public Contact - (ctoclinops@vcu.edu)
VCU Massey Comprehensive Cancer Center Richmond, Virginia	Site Public Contact - (CTOclinops@vcu.edu)
Washington University School of Medicine St Louis, Missouri	Site Public Contact - (info@siteman.wustl.edu)

A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)

Contact(s):

Toll Free Number - Trialsites@msd.com

Principal Investigator:

System ID: NCT06818643

Show full eligibility criteria

Interventions: BIOLOGICAL: MK-3120

Conditions: Advanced Solid Tumors, Malignant Neoplasm

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Study Locations

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Location	Contacts
Amsterdam UMC, locatie VUmc ( Site 0093) Amsterdam, North Holland
Ankara Bilkent Şehir Hastanesi. ( Site 0131) Çankaya, Ankara
Ankara University Health Practice and Research Hospitals ( Site 0134) Ankara,
Asan Medical Center ( Site 0153) Seoul,
Bradford Hill Centro de Investigaciones Clinicas ( Site 0030) Santiago, Region M. de Santiago
Cancer Institute Hospital of JFCR ( Site 0192) Koto, Tokyo
Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer-Medical Oncology ( Site 0054) Rennes, Ille-et-Vilaine
Centre Oscar Lambret ( Site 0051) Lille, Nord
Centro de Estudios Clínicos SAGA ( Site 0033) Santiago, Region M. de Santiago
Chi Mei Medical Center ( Site 0162) Tainan, Tainan
Chongqing Cancer Hospital ( Site 0186) Chongqing, Chongqing Municipality
Erasmus Medisch Centrum ( Site 0092) Rotterdam, South Holland
FALP ( Site 0031) Santiago, Region M. de Santiago
Gustave Roussy ( Site 0050) Villejuif, Val-de-Marne
HOSPITAL CLÍNIC DE BARCELONA ( Site 0112) Barcelona, Catalonia
Hacettepe Universite Hastaneleri ( Site 0130) Ankara,
Hospital Universitario Fundación Jiménez Díaz-START Madrid-FJD ( Site 0111) Madrid, Madrid, Comunidad de
Hospital Universitario Virgen de la Victoria ( Site 0114) Málaga,
Hunan Cancer Hospital ( Site 0181) Changsha, Hunan
Institut Català d'Oncologia - L'Hospitalet ( Site 0113) L'Hospitalet de Llobregat, Barcelona
Institut Paoli Calmettes ( Site 0053) Marseille, Bouches-du-Rhone
John Theurer Cancer Center at Hackensack University Medical Center ( Site 1009) Hackensack, New Jersey
Koc University, School of Medicine ( Site 0133) Istanbul,
National Cancer Center Hospital East ( Site 0190) Kashiwa, Chiba
National Cheng Kung University Hospital ( Site 0161) Tainan,
National Taiwan University Hospital ( Site 0160) Taipei,
Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 0090) Amsterdam, North Holland
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 0191) Osaka,
Peking University First Hospital ( Site 0180) Beijing, Beijing Municipality
Pontificia Universidad Catolica de Chile ( Site 0032) Santiago, Region M. de Santiago
Rabin Medical Center ( Site 0081) Petah Tikva,
Radboudumc ( Site 0091) Nijmegen, Gelderland
Rambam Health Care Campus ( Site 0082) Haifa,
Samsung Medical Center ( Site 0152) Seoul,
Seoul National University Hospital ( Site 0150) Seoul,
Severance Hospital Yonsei University Health System ( Site 0151) Seoul,
Sheba Medical Center ( Site 0080) Ramat Gan,
The First Hospital of Jilin University ( Site 0185) Changchun, Jilin
The University of Alabama at Birmingham ( Site 1005) Birmingham, Alabama
University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 1003) Miami, Florida
Virginia Commonwealth University ( Site 1008) Richmond, Virginia
West China Hospital Sichuan University ( Site 0187) Chengdu, Sichuan

C-SMART vs BE Well for Patients With Brain Tumors

Contact(s):

Sarah Braun, Ph.D - sarah.braun@vcuhealth.org

Principal Investigator:

System ID: NCT07224503

Show full eligibility criteria

Interventions: BEHAVIORAL: C-SMART, BEHAVIORAL: BE Well

Conditions: Brain Tumor

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Location	Contacts
Virginia Commonwealth University Richmond, Virginia	Sarah Braun, Ph.D - (sarah.braun@vcuhealth.org)

Comparing Radiation Therapy to Usual Care for Patients With High-Risk Bone Asymptomatic Metastases, PREEMPT Trial

Contact(s):

ctrrecruit@vcu.edu

Principal Investigator:

System ID: NCT06745024

Show full eligibility criteria

Interventions: OTHER: Best Practice, PROCEDURE: Biospecimen Collection, OTHER: Bone Metastases Treatment, PROCEDURE: Computed Tomography, PROCEDURE: Conventional Radiotherapy, PROCEDURE: Magnetic Resonance Imaging, OTHER: Patient Observation, OTHER: Questionnaire Administration, RADIATION: Stereotactic Body Radiation Therapy

Conditions: Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm

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Study Locations

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Location	Contacts
AIS Cancer Center at San Joaquin Community Hospital Bakersfield, California
AMG Crystal Lake - Oncology Crystal Lake, Illinois	Site Public Contact - (advocateresearch@advocate.com)
AMG Libertyville - Oncology Libertyville, Illinois	Site Public Contact - (advocateresearch@advocatehealth.com)
Abbott-Northwestern Hospital Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Adams Cancer Center Gettysburg, Pennsylvania
AdventHealth Daytona Beach Daytona Beach, Florida	Site Public Contact - (cfd-s.cancer.research@adventhealth.com)
AdventHealth Littleton Littleton, Colorado	Site Public Contact - (research.institute@adventhealth.com)
AdventHealth Parker Parker, Colorado	Site Public Contact - (research.institute@adventhealth.com)
AdventHealth Porter Denver, Colorado	Site Public Contact - (research.institute@adventhealth.com)
Advocate Christ Medical Center Oak Lawn, Illinois
Advocate Good Samaritan Hospital Downers Grove, Illinois	Site Public Contact - (Barbara.barhamand@advocatehealth.com)
Advocate Good Shepherd Hospital Barrington, Illinois
Advocate High Tech Medical Park Palos Heights, Illinois	Site Public Contact - (ncorp@aah.org)
Advocate Illinois Masonic Medical Center Chicago, Illinois
Advocate Lutheran General Hospital Park Ridge, Illinois
Advocate Outpatient Center - Aurora Aurora, Illinois	Site Public Contact - (ncorp@aah.org)
Advocate Sherman Hospital Elgin, Illinois
Advocate South Suburban Hospital Hazel Crest, Illinois
Alegent Health Bergan Mercy Medical Center Omaha, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Alegent Health Immanuel Medical Center Omaha, Nebraska
Alegent Health Lakeside Hospital Omaha, Nebraska
Alta Bates Summit Medical Center-Herrick Campus Berkeley, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Alton Memorial Hospital Alton, Illinois
Armes Family Cancer Center Findlay, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Aspirus Cancer Care - James Beck Cancer Center Rhinelander, Wisconsin	Site Public Contact - (Beth.Knetter@aspirus.org)
Aspirus Cancer Care - Stevens Point Stevens Point, Wisconsin	Site Public Contact - (Beth.Knetter@aspirus.org)
Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids, Wisconsin
Aspirus Medford Hospital Medford, Wisconsin	Site Public Contact - (Beth.Knetter@aspirus.org)
Aspirus Regional Cancer Center Wausau, Wisconsin
Asplundh Cancer Pavilion Willow Grove, Pennsylvania	Site Public Contact - (ONCTrialNow@jefferson.edu)
Atrium Health Cabarrus/LCI-Concord Concord, North Carolina
Atrium Health Cleveland/LCI-Cleveland Shelby, North Carolina
Atrium Health Pineville/LCI-Pineville Charlotte, North Carolina
Atrium Health Stanly/LCI-Albemarle Albemarle, North Carolina
Atrium Health Union/LCI-Union Monroe, North Carolina
Atrium Health University City/LCI-University Charlotte, North Carolina
Aurora Bay Area Medical Group-Marinette Marinette, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora BayCare Medical Center Green Bay, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Grafton Grafton, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Kenosha South Kenosha, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Milwaukee Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Racine Racine, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Southern Lakes VLCC Burlington, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Health Care Germantown Health Center Germantown, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Medical Center in Summit Summit, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Saint Luke's Medical Center Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Sinai Medical Center Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora West Allis Medical Center West Allis, Wisconsin	Site Public Contact - (ncorp@aurora.org)
BASS Medical Group - Lennon Walnut Creek, California
BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri
Banner MD Anderson Cancer Center Gilbert, Arizona
Banner North Colorado Medical Center Greeley, Colorado	Site Public Contact - (BMDACCResearchCOMailbox@bannerhealth.com)
Banner North Colorado Medical Center - Loveland Campus Loveland, Colorado	Site Public Contact - (BMDACCResearchCOMailbox@bannerhealth.com)
Banner University Medical Center - Tucson Tucson, Arizona	Site Public Contact - (UACC-IIT@uacc.arizona.edu)
Banner-University Medical Center Phoenix Phoenix, Arizona	Site Public Contact - (BannerResearch@bannerhealth.com)
Bay Pines VA Healthcare System Bay Pines, Florida	Site Public Contact - (vhabayresearch@va.gov)
Beebe Health Campus Rehoboth Beach, Delaware	Site Public Contact - (research@beebehealthcare.org)
Beebe Medical Center Lewes, Delaware	Site Public Contact - (research@beebehealthcare.org)
Beebe South Coastal Health Campus Millville, Delaware	Site Public Contact - (research@beebehealthcare.org)
Benefis Sletten Cancer Institute Great Falls, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Bethesda North Hospital Cincinnati, Ohio	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Billings Clinic Cancer Center Billings, Montana	Site Public Contact - (research@billingsclinic.org)
Blanchard Valley Hospital Findlay, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Bon Secours Cancer Institute at Reynolds Crossing Richmond, Virginia	Site Public Contact - (Anne_caramella@bshsi.org)
Bon Secours Memorial Regional Medical Center Mechanicsville, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Saint Francis Medical Center Midlothian, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Saint Mary's Hospital Richmond, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bozeman Health Deaconess Hospital Bozeman, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Bryn Mawr Hospital Bryn Mawr, Pennsylvania	Site Public Contact - (turzoe@mlhs.org)
CHI Health Good Samaritan Kearney, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
California Pacific Medical Center-Pacific Campus San Francisco, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Camden Clark Medical Center Parkersburg, West Virginia	Site Public Contact - (cancertrialsinfo@hsc.wvu.edu)
Cancer Care Center of O'Fallon O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Center at Saint Joseph's Phoenix, Arizona	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Cancer Center of Western Wisconsin New Richmond, Wisconsin	Site Public Contact - (mmcorc@healthpartners.com)
Carle BroMenn Medical Center Normal, Illinois	Site Public Contact - (Research@Carle.com)
Carle Cancer Center Urbana, Illinois	Site Public Contact - (Research@carle.com)
Carle Cancer Institute Normal Normal, Illinois	Site Public Contact - (Research@Carle.com)
Carle Physician Group-Effingham Effingham, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois	Site Public Contact - (Research@carle.com)
Carle at The Riverfront Danville, Illinois	Site Public Contact - (Research@Carle.com)
CaroMont Health - Lincoln Cancer Center Lincolnton, North Carolina
CaroMont Regional Medical Center Gastonia, North Carolina	Site Public Contact - (tammy.cozad@caromonthealth.org)
Carolinas Medical Center/Levine Cancer Institute Charlotte, North Carolina
Castle Medical Center Kailua, Hawaii
Central Maryland Radiation Oncology in Howard County Columbia, Maryland
Central Vermont Medical Center/National Life Cancer Treatment Berlin Corners, Vermont
Centralia Oncology Clinic Centralia, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Chambersburg Hospital Chambersburg, Pennsylvania	Site Public Contact - (Roster@nrgoncology.org)
Chelsea Hospital Chelsea, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Chester County Hospital West Chester, Pennsylvania	Site Public Contact - (carolann.hoppes@pennmedicine.upenn.edu)
Christiana Care Health System-Christiana Hospital Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Christiana Care Health System-Concord Health Center Chadds Ford, Pennsylvania	Site Public Contact - (lbarone@christianacare.org)
Christiana Care Health System-Wilmington Hospital Wilmington, Delaware	Site Public Contact - (lbarone@christianacare.org)
Cleveland Clinic Akron General Akron, Ohio	Site Public Contact - (CancerAnswer@ccf.org)
Cleveland Clinic Cancer Center Independence Independence, Ohio	Site Public Contact - (TaussigResearch@ccf.org)
Cleveland Clinic Cancer Center Mansfield Mansfield, Ohio	Site Public Contact - (TaussigResearch@ccf.org)
Cleveland Clinic Cancer Center Strongsville Strongsville, Ohio	Site Public Contact - (TaussigResearch@ccf.org)
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland, Ohio	Site Public Contact - (TaussigResearch@ccf.org)
Cleveland Clinic Foundation Cleveland, Ohio	Site Public Contact - (TaussigResearch@ccf.org)
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud, Minnesota	Site Public Contact - (coborncancercenter@centracare.com)
Community Medical Center Missoula, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Condell Memorial Hospital Libertyville, Illinois	Site Public Contact - (advocateresearch@advocatehealth.com)
Contra Costa Regional Medical Center Martinez, California
Cooper CyberKnife Center Mount Laurel, New Jersey	Site Public Contact - (research-cancer@cooperhealth.edu)
Cooper Hospital University Medical Center Camden, New Jersey
Creighton University Medical Center Omaha, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Crossroads Cancer Center Effingham, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Danbury Hospital Danbury, Connecticut
Dartmouth Cancer Center - North Saint Johnsbury, Vermont	Site Public Contact - (cancer.research.nurse@hitchcock.org)
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon, New Hampshire	Site Public Contact - (cancer.research.nurse@dartmouth.edu)
Dayton Physician LLC - Englewood Dayton, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Dayton Physicians LLC - Troy Troy, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Dayton Physicians LLC-Atrium Franklin, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Dayton Physicians LLC-Miami Valley South Centerville, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Dayton Physicians LLC-Wayne Greenville, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Decatur Memorial Hospital Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Delaware Health Center-Grady Cancer Center Delaware, Ohio	Site Public Contact - (Jennifer.Sexton@ohiohealth.com)
Doctors Hospital Columbus, Ohio	Site Public Contact - (Jennifer.Sexton@ohiohealth.com)
Dublin Methodist Hospital Dublin, Ohio	Site Public Contact - (Jennifer.Sexton@ohiohealth.com)
Duluth Clinic Ashland Ashland, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Eden Hospital Medical Center Castro Valley, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Edward Hospital/Cancer Center Naperville, Illinois
Elmhurst Memorial Hospital Elmhurst, Illinois	Site Public Contact - (Jrohde@emhc.org)
Emory Decatur Hospital Decatur, Georgia	Site Public Contact - (clinicaltrialsoncology@dekalbmedical.org)
Emory Saint Joseph's Hospital Atlanta, Georgia
Emory University Hospital Midtown Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute Atlanta, Georgia
Ephrata Cancer Center Ephrata, Pennsylvania
Essentia Health - Deer River Clinic Deer River, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - Fosston Fosston, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - Jamestown Clinic Jamestown, North Dakota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - Park Rapids Park Rapids, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Hibbing Clinic Hibbing, Minnesota
Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Saint Mary's Hospital - Superior Superior, Wisconsin
Essentia Health Saint Mary's Medical Center Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Sandstone Sandstone, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Virginia Clinic Virginia, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health-Hayward Clinic Hayward, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health-Spooner Clinic Spooner, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Fairbanks Memorial Hospital Fairbanks, Alaska
Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Southdale Hospital Edina, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fox Chase Cancer Center Philadelphia, Pennsylvania
Fresno Cancer Center Fresno, California	Site Public Contact - (Kpoct@kp.org)
Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Center Danville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Genesys Hurley Cancer Institute Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
George Washington University Medical Center Washington D.C., District of Columbia
Glens Falls Hospital Glens Falls, New York
Good Samaritan Hospital - Cincinnati Cincinnati, Ohio	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Goshen Center for Cancer Care Goshen, Indiana	Site Public Contact - (cccois@goshenhealth.com)
Grady Health System Atlanta, Georgia
Grady Memorial Hospital Delaware, Ohio	Site Public Contact - (Jennifer.Sexton@ohiohealth.com)
Grant Medical Center Columbus, Ohio	Site Public Contact - (Jennifer.Sexton@ohiohealth.com)
Great Falls Clinic Great Falls, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Greater Dayton Cancer Center Kettering, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Greater Regional Medical Center Creston, Iowa	Site Public Contact - (cancerresearch@mercydesmoines.org)
HSHS Saint Elizabeth's Hospital O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Hawaii Cancer Care - Westridge ‘Aiea, Hawaii	Site Public Contact - (info@hawaiicancercare.com)
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii	Site Public Contact - (i.webster@hawaiicancercare.com)
Hayworth Cancer Center High Point, North Carolina
Helen F Graham Cancer Center Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Hennepin County Medical Center Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Henry Ford Health Saint John Hospital Detroit, Michigan	Site Public Contact - (Kkeenan1@hfhs.org)
Henry Ford Health Warren Hospital Warren, Michigan	Site Public Contact - (kforman1@hfhs.org)
Henry Ford Saint John Hospital - Macomb Medical Macomb, Michigan	Site Public Contact - (kforman1@hfhs.org)
Henry Ford Saint John Hospital - Van Elslander Grosse Pointe Woods, Michigan	Site Public Contact - (kforman1@hfhs.org)
Hi-Line Sletten Cancer Center Havre, Montana	Site Public Contact - (Roster@nrgoncology.org)
Highland Hospital Rochester, New York
Hillcrest Hospital Cancer Center Mayfield Heights, Ohio	Site Public Contact - (TaussigResearch@ccf.org)
Holy Cross Hospital Fort Lauderdale, Florida	Site Public Contact - (eileen.georgi@holy-cross.com)
Hurley Medical Center Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
IRMC Cancer Center Indiana, Pennsylvania	Site Public Contact - (haneydl@upmc.edu)
IU Health Methodist Hospital Indianapolis, Indiana	Site Public Contact - (iutrials@iu.edu)
IU Health North Hospital Carmel, Indiana	Site Public Contact - (iutrials@iu.edu)
IU Health West Hospital Avon, Indiana	Site Public Contact - (iutrials@iu.edu)
Idaho Urologic Institute-Meridian Meridian, Idaho	Site Public Contact - (stephanie.couch@stjoeshealth.org)
Illinois CancerCare - Washington Washington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Bloomington Bloomington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Canton Canton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Carthage Carthage, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Dixon Dixon, Illinois
Illinois CancerCare-Eureka Eureka, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Galesburg Galesburg, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Macomb Macomb, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Pekin Pekin, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peoria Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peru Peru, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Princeton Princeton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana	Site Public Contact - (iutrials@iu.edu)
Indu and Raj Soin Medical Center Beavercreek, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Inova Alexandria Hospital Alexandria, Virginia	Site Public Contact - (Stephanie.VanBebber@inova.org)
Inova Fair Oaks Hospital Fairfax, Virginia	Site Public Contact - (Stephanie.VanBebber@inova.org)
Inova Loudoun Hospital Leesburg, Virginia	Site Public Contact - (Keary.janet@inova.org)
Inova Schar Cancer Institute Fairfax, Virginia	Site Public Contact - (Stephanie.VanBebber@inova.org)
Iowa Methodist Medical Center Des Moines, Iowa
James J Peters VA Medical Center The Bronx, New York	Site Public Contact - (kl2965@cumc.columbia.edu)
Jefferson Cherry Hill Hospital Cherry Hill, New Jersey	Site Public Contact - (ONCTrialNow@jefferson.edu)
Jefferson Torresdale Hospital Philadelphia, Pennsylvania	Site Public Contact - (ONCTrialNow@jefferson.edu)
Kaiser Permanente Cancer Treatment Center South San Francisco, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente Downtown Commons Sacramento, California	Site Public Contact - (kpoct@kp.org)
Kaiser Permanente Dublin Dublin, California
Kaiser Permanente Fresno Orchard Plaza Fresno, California
Kaiser Permanente Medical Center - Santa Clara Santa Clara, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente Medical Center-Vacaville Vacaville, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii	Site Public Contact - (shelley.a.clark@kp.org)
Kaiser Permanente Northwest Portland, Oregon	Site Public Contact - (information@kpchr.org)
Kaiser Permanente Oakland-Broadway Oakland, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente San Leandro San Leandro, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente- Marshall Medical Offices Redwood City, California
Kaiser Permanente-Deer Valley Medical Center Antioch, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Fremont Fremont, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Fresno Fresno, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Modesto Modesto, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Oakland Oakland, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Richmond Richmond, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Roseville Roseville, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-San Francisco San Francisco, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Santa Rosa Santa Rosa, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Santa Teresa-San Jose San Jose, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-South Sacramento Sacramento, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-South San Francisco South San Francisco, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Stockton Stockton, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Vallejo Vallejo, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Walnut Creek Walnut Creek, California	Site Public Contact - (Kpoct@kp.org)
Kaiser San Rafael-Gallinas San Rafael, California	Site Public Contact - (Kpoct@kp.org)
Kapiolani Medical Center for Women and Children Honolulu, Hawaii
Karmanos Cancer Institute at McLaren Greater Lansing Lansing, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
Kettering Medical Center Kettering, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Kuakini Medical Center Honolulu, Hawaii
Lakeview Hospital Stillwater, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Langlade Hospital and Cancer Center Antigo, Wisconsin	Site Public Contact - (Juli.Alford@aspirus.org)
Lankenau Medical Center Wynnewood, Pennsylvania	Site Public Contact - (turzoe@mlhs.org)
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York	Site Public Contact - (CancerTrials@nyulangone.org)
Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Lenox Hill Hospital New York, New York
Logan Health Medical Center Kalispell, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Longmont United Hospital Longmont, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Loyola University Medical Center Maywood, Illinois
MD Anderson Cancer Center at Cooper-Voorhees Voorhees Township, New Jersey
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia, Missouri
MaineHealth Cancer Care Center of York County Sanford, Maine
MaineHealth Cancer Care and IV Therapy - South Portland South Portland, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
MaineHealth Coastal Cancer Treatment Center Bath, Maine	Site Public Contact - (Roster@nrgoncology.org)
MaineHealth LincolnHealth Hospital Damariscotta, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
MaineHealth Maine Medical Center - Portland Portland, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
MaineHealth Maine Medical Center- Scarborough Scarborough, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
MaineHealth Waldo Hospital Belfast, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
Manhattan Eye Ear and Throat Hospital New York, New York
Marshfield Medical Center - Weston Weston, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Marshfield Marshfield, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Mary Greeley Medical Center Ames, Iowa
Maryland Proton Treatment Center Baltimore, Maryland	Site Public Contact - (info@mdproton.com)
McFarland Clinic - Ames Ames, Iowa	Site Public Contact - (ksoder@mcfarlandclinic.com)
McLaren Cancer Institute-Bay City Bay City, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Central Michigan Mount Pleasant, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Clarkston Clarkston, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Flint Flint, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Lapeer Region Lapeer, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Macomb Mount Clemens, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren Cancer Institute-Northern Michigan Petoskey, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
McLaren-Port Huron Port Huron, Michigan	Site Public Contact - (ctoadmin@karmanos.org)
Medical Oncology Hematology Consultants PA Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Medical University of South Carolina Charleston, South Carolina	Site Public Contact - (hcc-clinical-trials@musc.edu)
Memorial Hermann Texas Medical Center Houston, Texas
Memorial Hospital East Shiloh, Illinois	Site Public Contact - (dschwab@wustl.edu)
Memorial Hospital North Colorado Springs, Colorado
Memorial Hospital of Carbondale Carbondale, Illinois	Site Public Contact - (clinical.research@sih.net)
Memorial Medical Center Modesto, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Memorial Medical Center-Las Cruces Las Cruces, New Mexico	Site Public Contact - (Deborah.Brown@LPNT.net)
Mercy Cancer Center - Carmichael Carmichael, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Elk Grove Elk Grove, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Rocklin Rocklin, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Sacramento Sacramento, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center-West Lakes Clive, Iowa	Site Public Contact - (cancerresearch@mercydesmoines.org)
Mercy Hospital Cedar Rapids, Iowa	Site Public Contact - (mmcorc@healthpartners.com)
Mercy Medical Center - Des Moines Des Moines, Iowa	Site Public Contact - (cancerresearch@mercydesmoines.org)
Mercy Medical Center-West Lakes West Des Moines, Iowa	Site Public Contact - (cancerresearch@mercydesmoines.org)
Mercy San Juan Medical Center Carmichael, California	Site Public Contact - (OncologyResearch@DignityHealth.org)
Methodist Medical Center of Illinois Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Miami Cancer Institute Miami, Florida
Michigan Healthcare Professionals Pontiac Pontiac, Michigan	Site Public Contact - (Emily.Crofts@trinity-health.org)
Miller-Dwan Hospital Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Mills Health Center San Mateo, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Mills-Peninsula Medical Center Burlingame, California	Site Public Contact - (clinicalresearch@sutterhealth.org)
Minnesota Oncology - Burnsville Burnsville, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mission Hope Medical Oncology - Santa Maria Santa Maria, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Missouri Baptist Medical Center St Louis, Missouri
Missouri Baptist Sullivan Hospital Sullivan, Missouri
Moffitt Cancer Center Tampa, Florida	Site Public Contact - (ClinicalTrials@moffitt.org)
Moffitt Cancer Center - McKinley Campus Tampa, Florida	Site Public Contact - (ClinicalTrials@moffitt.org)
Moffitt Cancer Center at SouthShore Ruskin, Florida	Site Public Contact - (ClinicalTrials@moffitt.org)
Moffitt Cancer Center at Wesley Chapel Wesley Chapel, Florida	Site Public Contact - (ClinicalTrials@moffitt.org)
Moffitt Cancer Center-International Plaza Tampa, Florida	Site Public Contact - (ClinicalTrials@moffitt.org)
Montefiore Medical Center - Moses Campus The Bronx, New York	Site Public Contact - (eskwak@montefiore.org)
Montefiore Medical Center-Einstein Campus The Bronx, New York	Site Public Contact - (eskwak@montefiore.org)
Monticello Cancer Center Monticello, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Mount Sinai Chelsea New York, New York	Site Public Contact - (CCTO@mssm.edu)
Mount Sinai Hospital New York, New York	Site Public Contact - (CCTO@mssm.edu)
Mount Sinai Queens Astoria, New York	Site Public Contact - (CCTO@mssm.edu)
Mount Sinai Union Square New York, New York	Site Public Contact - (CCTO@mssm.edu)
Mount Sinai West New York, New York	Site Public Contact - (CCTO@mssm.edu)
MyMichigan Medical Center Gratiot Alma, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Midland Midland, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Saginaw Saginaw, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
MyMichigan Medical Center Tawas Tawas City, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York, New York	Site Public Contact - (cancerclinicaltrials@cumc.columbia.edu)
NYU Langone Hospital - Brooklyn Brooklyn, New York	Site Public Contact - (david.wallach@nyulangone.org)
NYU Langone Hospital - Long Island Mineola, New York	Site Public Contact - (cancertrials@nyulangone.org)
Nebraska Medicine-Bellevue Bellevue, Nebraska	Site Public Contact - (unmcrsa@unmc.edu)
Nebraska Medicine-Village Pointe Omaha, Nebraska
New York-Presbyterian Westchester Hospital Bronxville, New York	Site Public Contact - (cancerclinicaltrials@cumc.columbia.edu)
North Coast Cancer Care Sandusky, Ohio	Site Public Contact - (TaussigResearch@ccf.org)
North Memorial Medical Health Center Robbinsdale, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Northwell Health Cancer Institute at Huntington Greenlawn, New York
Northwell Health Imbert Cancer Center Bay Shore, New York
Northwell Health Physicians Partners Radiation Medicine at Queens Forest Hills, New York
Northwell Health/Center for Advanced Medicine Lake Success, New York
Northwest Cancer Center - Hobart Hobart, Indiana
Northwest Cancer Center - Main Campus Crown Point, Indiana
Northwest Cancer Center - Valparaiso Valparaiso, Indiana	Site Public Contact - (CancerResearch@COMHS.org)
Northwest Oncology LLC Dyer, Indiana
Northwest Wisconsin Cancer Center Ashland, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Northwestern Medicine Cancer Center Delnor Geneva, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Cancer Center Kishwaukee DeKalb, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Oak Brook Oak Brook, Illinois	Site Public Contact - (nctnprogram_rhlccc@northwestern.edu)
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Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

Contact(s):

Gwen Nichols, MD - gwen.nichols@lls.org

Principal Investigator:

System ID: NCT05183035

Show full eligibility criteria

Inclusion Criteria * Participants must have enrolled on APAL2020SC, NCT Number: NCT04726241 prior to enrollment on ITCC-101/APAL2020D. (This is only applicable for participants in USA/Canada/Australia/New Zealand sites/Blood Cancer United territory). * Participants must be ≥ 29 days of age and ≤ 21 years of age at enrollment. * Participants must have one of the following:
• Children, adolescents, and young adults with AML without demonstrated FLT3/internal tandem duplication (ITD) mutation. Ideally, the status of the mutation needs to be proven in the current relapse. Nevertheless, patients with previous FLT3/ITD negative test from prior lines can be included based on local results in order to not delay the start of treatment.
• And participants must have AML which is either: * Untreated second relapse, in participants who are sufficiently fit to undergo another round of intensive chemotherapy, or * Untreated first relapse, in participants who cannot tolerate additional anthracycline containing chemotherapy per investigator discretion. * Participants must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2 (≥ 50% Lansky or Karnofsky score). * Participants must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to start of protocol treatment:
• Cytotoxic chemotherapy: Must not have received cytotoxic chemotherapy within 14 days prior to start of protocol treatment, except for corticosteroids, low dose cytarabine or hydroxyurea that can be given up to 24 hours prior to start of protocol treatment.
• Intrathecal cytotoxic therapy: No wash-out time is required for participants having received any combination of intrathecal cytarabine, methotrexate, and/or hydrocortisone.
• Antibodies: ≥ 21 days must have elapsed from infusion of last dose of an antibody-drug conjugate before start of protocol treatment. For unmodified antibodies or T cell engaging antibodies, 2 half-lives must have elapsed before start of protocol treatment. Any toxicity related to prior antibody therapy must be recovered to Grade ≤ 1.
• Interleukins, Interferons and Cytokines (other than Hematopoietic Growth Factors): ≥ 21 days after the completion of interleukins, interferon or cytokines (other than Hematopoietic Growth Factors) before start of protocol treatment.
• Hematopoietic growth factors: ≥ 14 days after the last dose of a long-acting growth factor (e.g., pegfilgrastim) or ≥7 days for short-acting growth factor before start of protocol treatment.
• Radiation therapy (RT) (before start of protocol treatment): * ≥ 14 days have elapsed for local palliative RT (small port); * ≥ 84 days must have elapsed if prior craniospinal RT or if ≥ 50% radiation of pelvis; * ≥ 42 days must have elapsed if other substantial bone marrow (BM) radiation.
• Stem Cell Infusions (before start of protocol treatment): * ≥ 84 days since allogeneic (non-autologous) bone marrow or stem cell transplant (with or without total body irradiation \[TBI\]) or boost infusion (any stem cell product; not including donor lymphocyte infusion \[DLI\]); * No evidence of active graft versus host disease (GVHD).
• Participants who are receiving cyclosporine, tacrolimus or other agents to treat or prevent either graft-versus-host disease post bone marrow transplant or organ rejection post-transplant are not eligible for this trial. Participants must be off medications to treat or prevent either graft-versus-host disease post bone marrow transplant or organ rejection post-transplant for at least 14 days prior to enrollment.
• Cellular Therapy: ≥ 42 days after the completion of donor lymphocyte infusion (DLI) or any type of cellular therapy (e.g., modified T cells, natural killer \[NK\] cells, dendritic cells, etc.) before start of protocol treatment.
• Participants with prior exposure to venetoclax are eligible in this trial. * Adequate organ function:
• Adequate Renal Function defined as: * Creatinine clearance or radioisotope glomerular filtration rate (GFR) ≥ 60ml/min/1.73 m\^2, or * Normal serum creatinine based on age/sex
• Adequate Liver Function defined as: * Direct bilirubin \< 1.5 x upper limit of normal (ULN), and * Alkaline phosphatase ≤ 2.5 x ULN, and * Serum glutamic pyruvic transaminase (SGPT) alanine aminotransferase (ALT) ≤ 2.5 x ULN. If higher transaminases outside these ranges (up to 5x ULN) are due to a radiographically identifiable leukemia infiltrate, the participant will remain eligible. Transaminase elevation up to 5x ULN is also allowed in case of steatosis on echography.
• Cardiac performance: Minimum cardiac function defined as: * No history of congestive heart failure in need of medical treatment * No pre-treatment diminished left ventricular function on echocardiography (shortening fraction \[SF\] \< 25% or ejection fraction \[EF\] \< 40%) * No signs of congestive heart failure at presentation of relapse. * Participant, parent or guardian must sign and date informed consent and pediatric assent (when required), prior to the initiation of screening or study specific procedures, according to local law and legislation. Exclusion Criteria * Participants who in the opinion of the investigator may not be able to comply with the study requirements of the study, are not eligible. * Participants with Down syndrome. * Participants with Acute promyelocytic leukemia (APL) or Juvenile myelomonocytic leukemia (JMML). * Participants with isolated CNS3 disease or symptomatic CNS3 disease. * Participants with malabsorption syndrome or any other condition that precludes enteral administration of venetoclax. * Participants who are currently receiving an investigational drug other than those specified for this study. * Participants with Fanconi anemia, Kostmann syndrome, Shwachman syndrome or any other known congenital bone marrow failure syndrome. * Participants with known prior allergy to any of the medications used in protocol therapy. * Participants with documented active, uncontrolled infection at the time of study entry. * Known hepatitis C virus (HCV), hepatitis B virus (HBV) (known positive hepatitis B virus (HBV) surface antigen (HBsAg) results), or human immunodeficiency virus (HIV) infection. * Concomitant Medications * Participants who have received strong and moderate CYP3A inducers such as rifampin, carbamazepine, phenytoin, and St. John's wort within 7 days of the start of study treatment. * Participants who have consumed grapefruit, grapefruit products, Seville oranges (including marmalade containing Seville oranges) or starfruit within 3 days of the start of study treatment. * Participants who have hypersensitivity to the active substance or to any of the excipients listed in summary of product characteristics (SPC). * Pregnancy or Breast-Feeding: * Participants who are pregnant or breast-feeding. * Participants of reproductive potential may not participate unless they have agreed to use a highly effective contraceptive method per Clinical Trial Facilitation Group (CTFG) guidelines for the duration of study therapy and at least 30 days after last dose of venetoclax, or 7 months after gemtuzumab ozogamicin treatment, or for 6 months after the completion of all study therapy, whichever is longer. * Male participants must use a condom during intercourse and agree not to father a child or donate sperm during therapy and for the duration of study therapy and at least 30 days after last dose of venetoclax or 4 months after last dose of gemtuzumab ozogamicin, 6 months from the last dose of cytarabine, or 90-days after last exposure to any other chemotherapy, whichever is longer. Additional criteria to receive a gemtuzumab ozogamicin infusion: Gemtuzumab ozogamicin should not be given: * to participants with history of veno-occlusive disease (VOD)/Sinusoidal obstruction syndrome (SOS) grade 3 or 4 * to participants with CD33 negative leukemic blasts (determined at local lab) Note that these participants are eligible for the study but will not be treated with gemtuzumab ozogamicin.

Interventions: DRUG: Fludarabine, DRUG: Cytarabine, DRUG: Gemtuzumab Ozogamicin, DRUG: Azacitidine, DRUG: Venetoclax

Conditions: Acute Myeloid Leukemia

Keywords: Venetoclax, Gemtuzumab Ozogamicin, Fludarabine, Cytarabine, Relapsed refractory, Azacitidine

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Study Locations

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Location	Contacts
Alberta Children's Hospital Calgary, Alberta
Alliance for Childhood Diseases dba Cure 4 The Kids Foundation Las Vegas, Nevada
Ann & Robert H. Lurie Children's Hospital of Chicago Chicago, Illinois
Arkansas Children's Hospital Little Rock, Arkansas
Benioff Children's Hospital - Mission Bay San Francisco, California
British Columbia Children's Hospital Vancouver, British Columbia
C.S. Mott Children's Hospital Ann Arbor, Michigan
CHU de Nantes - Hôpital Femme-Enfant-Adolescent Nantes, Loire-Atlantique
CHU de Toulouse - Hopital des Enfants Toulouse, Haute-Garonne
CancerCare Manitoba Winnipeg, Manitoba
Charite - Universitatsmedizin Berlin Berlin,
Children's Health Queensland Hospital and Health Service South Brisbane, Queensland
Children's Healthcare of Atlanta Atlanta, Georgia
Children's Hospital Colorado Aurora, Colorado
Children's Hospital Of Eastern Ontario Ottawa, Ontario
Children's Hospital of Michigan Detroit, Michigan
Children's Hospital of Orange County Main Campus - Orange Orange, California
Children's Hospital of Philadelphia Philadelphia, Pennsylvania
Children's Hospital of Richmond at Virginia Commonwealth University Richmond, Virginia
Cohen Children's Medical Center Queens, New York
Columbia University Irving Medical Center New York, New York
Comer Children's Hospital Chicago, Illinois
Dana-Farber Cancer Institute Boston, Massachusetts
Doernbecher Children's Hospital Portland, Oregon
Fakultni nemocnice v Motole Prague, Prague
Fondazione IRCCS San Gerardo dei Tintori Monza, Monza and Brianza
Golisano Children's Hospital of Southwest Florida Fort Myers, Florida
Hackensack University Medical Center, HMH Hackensack, New Jersey
Harold C. Simmons Comprehensive Cancer Center Dallas, Texas
Hopital Jeanne de Flandre Loos, Hauts-de-France
Hospital Infantil Universitario Nino Jesus Madrid,
Hospital Sant Joan de Déu Barcelona Barcelona,
Hospital Universitari Vall d'Hebron Barcelona,
Hospital Universitario La Fe Valencia,
Hyogo Prefectural Kobe Children's Hospital Kobe, Hyōgo
Hôpital Armand-Trousseau Paris, Île-de-France Region
Hôpital Universitaire Robert-Debré Paris, Île-de-France Region
Indiana University School of Medicine Indianapolis, Indiana
Institut d'Hématologie et d'Oncologie Pédiatrique Lyon, Rhône
Instituto Portugues De Oncologia De Lisboa Francisco Gentil Lisbon, Lisbon District
Istituto Giannina Gaslini Genova, Genoa
Izaak Walton Killam (IWK) Health Center Halifax, Nova Scotia
Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya, Aiti
Kapi'olani Medical Center for Women and Children Honolulu, Hawaii
Karolinska Universitetssjukhuset Solna Stockholm, Stockholm County
Masonic Cancer Center Minneapolis, Minnesota
Memorial Sloan Kettering Cancer Center - New York New York, New York
MemorialCare Miller Children's and Women's Hospital Long Beach Long Beach, California
Monroe Carell Jr. Children's Hospital at Vanderbilt Nashville, Tennessee
Morristown Medical Center Morristown, New Jersey
National Center for Child Health and Development Setagaya-Ku, Tokyo
Nationwide Children's Hospital Columbus, Ohio
Nemours Alfred I. duPont Hospital for Children Wilmington, Delaware
Nemours Children's Hospital - Orlando Orlando, Florida
Nemours Children's Specialty Care Jacksonville Jacksonville, Florida
Norton Children's Hospital Louisville, Kentucky
Osaka City General Hospital Osaka,
Oslo Universitetssykehus Oslo,
Ospedale Infantile Regina Margherita Torino, Turin
Ospedale Pediatrico Bambino Gesu Roma, Rome
Padiatrische Hamatologie und Onkologie Münster,
Perth Children's Hospital Perth, Western Australia
Phoenix Children's Hospital Phoenix, Arizona
Primary Children's Hospital Salt Lake City, Utah
Prinses Maxima Centrum Kinderoncologie Utrecht,
Prisma Health Richland Hospital Columbia, South Carolina
Rigshospitalet Copenhagen, Capital Region
Saint Joseph's Hospital - Tampa Tampa, Florida
Saitama Prefectural Children's Medical Center Saitama-Shi, Saitama
Sankt Anna-Kinderspital Vienna,
Schneider Children's Medical Center of Israel Petach Tikvah, Central District
Seattle Children's Hospital Seattle, Washington
SickKids - The Hospital for Sick Children Toronto, Ontario
St. Jude Children's Research Hospital Memphis, Tennessee
Starship Children's Hospital Grafton, Auckland
Texas Children's Hospital Houston, Texas
The Children's Mercy Hospital - Adele Hall Campus Kansas City, Missouri
The Royal Children's Hospital - Children's Cancer Centre Parkville, Victoria
Universitaets - Kinderspital Zürich Zurich,
Universitair Ziekenhuis Gent Ghent, Oost-Vlaanderen
University of Florida Health Shands Children's Hospital Gainesville, Florida
University of Iowa Stead Family Children's Hospital Iowa City, Iowa
University of Mississippi Medical Center Jackson, Mississippi
Universitätsklinikum Augsburg Augsburg,
Universitätsklinikum Frankfurt Frankfurt,
Universitätsklinikum Münster Münster,
Uusi Lastensairaala Helsinki, Etelä-Suomen Lääni
Washington University School of Medicine in St. Louis St Louis, Missouri
Yale University New Haven, Connecticut

Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases

Contact(s):

Ryan Gentzler, MD, MS - rg2uc@uvahealth.org

Principal Investigator:

System ID: NCT06248606

Show full eligibility criteria

Inclusion Criteria:

• Written informed consent and HIPAA authorization for release of personal health information prior to registration. NOTE: HIPAA authorization may be included in the informed consent or obtained separately.
• Age ≥ 18 years at the time of consent.
• ECOG Performance Status of 0-1 within 28 days prior to registration.
• Confirmation of stage IV non-small cell lung cancer (NSCLC) per AJCC, 8th edition, or metastatic recurrence after treatment for earlier stage disease.
• Known to have a KRAS G12C mutation. KRAS G12C mutation can be determined based on local tissue and/or ctDNA testing.
• Presence of brain metastases that meet the following criteria: * Patients must have at least 1 untreated enhancing intracranial lesion, per local radiology interpretation, measuring at least 2mm. NOTE: intracranial lesions do not need to be measurable by RECIST 1.1 criteria to be eligible. * Must have no single metastasis measuring larger than 3 cm. * Patients with surgically resected brain metastases are eligible provided there are additional brain metastases amenable to SRS * Patients with progression of previously radiated or surgically resected CNS metastases are eligible if solid component of lesion has enlarged and there is no concern for radionecrosis based on investigator discretion. * Patients who received SRS within 4 weeks prior to registration are eligible provided baseline brain MRI prior to SRS treatment is within 4 weeks of study registration and SRS treatment meets requirements in #7 below. * Symptomatic brain metastases are permitted if the following criteria are met: * No evidence of cerebral herniation or symptomatic leptomeningeal disease * No seizures within past 14 days; antiepileptic medications are permitted * Patients on steroids must have stable or improving neurologic symptoms that have not worsened during a steroid taper. Must be receiving the equivalent of dexamethasone 8 mg total daily dose or less at the time of registration.
• CNS lesions have already been treated with SRS (within 3 weeks prior to Cycle 1 Day 1) or are amenable to SRS as determined by radiation oncologist and/or neurosurgeon. SRS treatment must use GammaKnife or linear accelerator-based treatments with nominal x-ray energy of 6MV or greater.
• No contraindications to SRS. Patients on anticoagulation must be able to hold anticoagulation for SRS treatment based on investigator discretion.
• Patients may be treatment-naïve OR have received up to 2 prior lines of systemic therapy. Treatment with systemic therapy for Stage I-III disease \> 12 months prior to development of metastases do not count as a line of therapy. Treatment with platinum-doublet chemotherapy and checkpoint inhibitor immunotherapy (PD-1, PD-L1, CTLA-4, etc.) either in combination or sequentially counts as one line of therapy.
• Demonstrate adequate organ function as defined below. All screening labs to be obtained within 28 days prior to registration. * Hemoglobin (Hgb): ≥ 8.0 g/dL in the absence of transfusions within 7 days prior to testing. * Calculated creatinine clearance: ≥ 60 mL/min * Bilirubin: ≤ 1.5 mg/dL * Aspartate aminotransferase (AST): ≤ 3.0 × ULN * Alanine aminotransferase (ALT): ≤ 3.0 × ULN
• Females of childbearing potential must have a negative urine or serum pregnancy test within 7 days prior to treatment initiation.
• Females of childbearing potential who are sexually active with a male able to father a child must be willing to abstain from heterosexual activity or to use an effective method(s) of contraception. Males able to father a child who are sexually active with female of childbearing potential must be willing to abstain from heterosexual activity or to use an effective method(s) of contraception.
• HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of registration are eligible for this trial. Testing is not required at screening unless mandated by local policy.
• Patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, the HCV viral load must be undetectable to be eligible for this trial. Testing is not required at screening unless mandated by local policy.
• As determined by the enrolling physician or protocol designee, ability of the subject to understand and comply with study procedures for the entire length of the study.

Exclusion Criteria:

• Prior treatment with KRAS G12C tyrosine kinase inhibitor.
• Active infection requiring systemic therapy with the exception of #13 and #14 above.
• Uncontrolled, significant intercurrent or recent illness.
• Prolonged QTc interval \> 480 milliseconds or history of congenital Long QT Syndrome
• Currently receiving radiation treatment at the time of enrollment to any extra-cranial lesion for prophylaxis or pain control. Patients may enroll after completion of palliative RT.
• Ongoing need for treatment with concomitant medication known as a strong inhibitor or inducer of CYP3A enzyme and that cannot be switched to an alternative treatment prior to study enrollment. NOTE: Discontinuation of CYP3A4 inducers should occur a minimum of 7 days or 5 times their half-life, whichever is longer, prior to C1D1 study treatment.
• Treatment with any investigational drug within 28 days prior to registration.
• Pregnant or breastfeeding (NOTE: breast milk cannot be stored for future use while the mother is being treated on study).
• Patients with a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment of the investigational regimen, per treating physician discretion, are not eligible for this trial.

Interventions: DRUG: Adagrasib, RADIATION: Stereotactic Radiosurgery

Conditions: Non Small Cell Lung Cancer, NSCLC, KRAS G12C

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Study Locations

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Location	Contacts
University of Virginia Health System Charlottesville, Virginia	Gracie Hockenberry, RN - (mgt4n@virginia.edu)
Virginia Commonwealth University Richmond, Virginia	Nicole Knight - (nknight@vcu.edu)

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma (MajesTEC-7)

Contact(s):

Study Contact - Participate-In-This-Study1@its.jnj.com

Principal Investigator:

System ID: NCT05552222

Show full eligibility criteria

Interventions: DRUG: Teclistamab, DRUG: Daratumumab, DRUG: Lenalidomide, DRUG: Dexamethasone, DRUG: Talquetamab

Conditions: Multiple Myeloma

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Study Locations

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Location	Contacts
A O U Sant Orsola Malpighi Bologna,
ASST Papa Giovanni XXIII Bergamo Bergamo,
AZ Groeninge Kortrijk,
Aalborg University Hospital Aalborg,
Addenbrooke's Hospital Cambridge,
Alexander T. Augusta Military Medical Center Fort Belvoir, Virginia
Alexandra General Hospital of Athens Athens Attica,
Allegheny Health Network Pittsburgh, Pennsylvania
Ankara University Medical Faculty Ankara,
Anticancer Hospital of Thessaloniki Theageneio Thessaloniki,
Arthur J E Child Comprehensive Cancer Centre Calgary, Alberta
Asan Medical Center Seoul,
Astera Cancer Care East Brunswick, New Jersey
Atrium Health Wake Forest Baptist Comprehensive Cancer Center Winston-Salem, North Carolina
Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino Torino,
Azienda Ospedaliera di Rilievo Nazionale A Cardarelli Naples,
Banner MD Anderson Cancer Center Gilbert, Arizona
Barwon Health - University Hospital Geelong Geelong,
Beijing Chaoyang Hospital Chaoyang District,
Beijing Tongren Hospital CMU Beijing,
Blackpool Victoria Hospital Blackpool,
British Columbia Cancer Agency Vancouver, British Columbia
CHU Henri Mondor Créteil,
CHU Hôpital Saint Antoine Paris,
CHU Lyon Sud Pierre-Bénite,
CHU Nantes Nantes,
CHU Poitiers - Hopital la Miletrie Poitiers,
CHU de Bordeaux - Hospital Haut-Leveque Pessac,
CHU de Quebec L Hotel Dieu de Quebec Québec, Quebec
CHU de Rennes - Hopital Pontchaillou Rennes,
Calvary Mater Newcastle Hospital Waratah, New South Wales
Cancer And Hematology Centers of Western Michigan PC Grand Rapids, Michigan
Cancer and Blood Specialty Clinic Los Alamitos, California
Careggi University Hospital Florence,
Center For Cancer and Blood Disorders Bethesda, Maryland
Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli Lublin,
Champalimaud Foundation Champalimaud Centre Lisbon,
Changzhou No 2 Peoples Hospital Changzhou,
Chiba Cancer Center Chiba,
Chongqing University Cancer Hospital Chongqing,
Chonnam National University Hwasun Hospital Jeollanam-do,
ChristianaCare Helen F Graham Cancer Center and Research Institute Newark, Delaware
Christus St. Vincent Regional Cancer Center Santa Fe, New Mexico
City of Hope Orange County Lennar Foundation Cancer Center Irvine, California
City of Hope cancer Center Newnan, Georgia
City of Hope cancer Center Newnan, Georgia
Cleveland Clinic Florida Weston, Florida
Cleveland Clinic Main Campus Cleveland, Ohio
Clinica Medica Sao Germano S/S LTDA São Paulo,
Complexo Hospitalar de Niterói Niterói,
Cross Cancer Institute Edmonton, Alberta
Dartmouth Hitchcock Medical Center Lebanon, New Hampshire
Dokuz Eylul University Medical Faculty Izmir,
Dong-A University Hospital Busan,
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital Ankara,
Durham VAMC Durham, North Carolina
Fakultni Nemocnice Ostrava Ostrava - Poruba,
Fakultni nemocnice Brno Brno,
Fakultni nemocnice Hradec Kralove Hradec Králové,
Fakultni nemocnice Olomouc Olomouc,
Fakultni nemocnice Plzen Pilsen,
Falu Lasarett Falun,
Fujian Meidical University Union Hospital Fuzhou,
Fujita Health University Hospital Toyoake,
Fundacao Pio XII Barretos,
G Papanikolaou Hospital of Thessaloniki Thessalonikis,
GZA Ziekenhuizen- Campus St Augustinus Wilrijk,
Gachon University Gil Medical Center Incheon,
Gelre Ziekenhuis Apeldoorn,
Ghent University Hospital Ghent,
Hanusch Krankenhaus Vienna,
Harbin Medical University Cancer Hospital Harbin,
Helios Kliniken Berlin Buch Gmbh Berlin,
Hematology-Oncology Associates of CNY East Syracuse, New York
Henan Cancer Hospital Zhengzhou,
Henry Ford Cancer - Detroit Brigitte Harris Cancer Pavilion Detroit, Michigan
Henry Ford Providence Novi Hospital Novi, Michigan
Henry Ford Providence Southfield CK Potluri Cancer Center Southfield, Michigan
Hopital Claude Huriez Lille,
Hopitaux Universitaires de Strasbourg - Hopital de Hautepierre Strasbourg,
Hosp Clinico Univ de Salamanca Salamanca,
Hosp Univ Hm Sanchinarro Madrid,
Hosp Univ Vall D Hebron Barcelona,
Hosp. Clinico Univ. de Valencia Valencia,
Hosp. Mutua Terrassa Terrassa,
Hosp. Quiron Madrid Pozuelo Pozuelo de Alarcón,
Hosp. Univ. 12 de Octubre Madrid,
Hosp. Univ. Germans Trias I Pujol Badalona,
Hosp. Univ. La Paz Madrid,
Hosp. Univ. Son Espases Palma de Mallorca,
Hosp. Univ. Virgen de Las Nieves Granada,
Hosp. de Jerez de La Frontera Jerez de la Frontera,
Hosp. de La Santa Creu I Sant Pau Barcelona,
Hospital Das Clinicas Da Faculdade De Medicina Da USP São Paulo,
Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP Ribeirão Preto,
Hospital Nove de Julho São Paulo,
Hospital Sao Rafael Salvador,
Hospital de Clínicas de Porto Alegre Porto Alegre,
Hyogo Medical University Hospital Hyôgo,
Imperial College Healthcare London,
Inselspital Universitätsspital Bern Bern,
Institut Catala d Oncologia L Hospitalet Barcelona,
Institut Jules Bordet Anderlecht,
Institut Universitaire du Cancer Toulouse Oncopole Toulouse,
Institute of Hematology and Blood Diseases Hospital Tianjin,
Instituto Portugues de Oncologia Porto,
Instituto do Cancer do Ceara Fortaleza,
Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi Pavia,
Istituto Clinico Humanitas Rozzano,
Japanese Red Cross Medical Center Shibuya-ku,
Joe Arrington Cancer Research Treatment Center Lubbock, Texas
Johns Hopkins University School of Medicine JHUSOM Baltimore, Maryland
Jolimont Haine Saint Paul La Louviere,
Juntendo University Hospital Bunkyō City,
Kameda Medical Center Chiba,
Kanazawa University Hospital Kanazawa,
Kansai Medical University Hospital Hirakata,
Kantonsspital St Gallen Sankt Gallen,
Karolinska University Hospital Huddinge Stockholm,
Kent and Canterbury Hospital Canterbury,
Klinikum Nuernberg Nord Nuremberg,
Kumamoto University Hospital Kumamoto,
Kyungpook National University Hospital Daegu,
LSUHSC Shreveport Feist-Weiller Cancer Center Shreveport, Louisiana
Levine Cancer Institute Charlotte, North Carolina
Liga Norte Riograndense Contra O Cancer Natal,
Liga Paranaense de Combate ao Cancer Curitiba,
Liv Hospital Ankara Ankara,
Liverpool Hospital Liverpool,
Matsuyama Red Cross Hospital Matsuyama,
Med. Universitatsklinik Essen Essen,
Medical University Vienna Vienna,
Medipol University Hospital Istanbul,
Memorial Antalya Hospital Antalya,
Memorial Sloan Kettering Cancer Center New York, New York
NYU Langone Hospital Long Island Mineola, New York
Nanfang Hospital Guangzhou,
Nanjing Drum Tower Hospital Nanjing,
National Cancer Center Gyeonggi-do,
National Hospital Organization Hokkaido Cancer Center Sapporo,
National Hospital Organization Mito Medical Center Higashiibaraki-gun,
National Hospital Organization Nagasaki Medical Center Nagasaki,
National Hospital Organization Okayama Medical Center Okayama,
National Hospital Organization Shibukawa Medical Center Shibukawa,
Nebraska Cancer Specialists Omaha, Nebraska
New Cross Hospital Wolverhampton,
No.1 Affiliated Hospital, Medical College of Zhejiang University Hangzhou,
Northwell Health Cancer Institute Lake Success, New York
Northwest Medical Specialties, PLLC Tacoma, Washington
Norton Cancer Institute Louisville, Kentucky
Novant Health Winston-Salem, North Carolina
Novant Health Forsyth Medical Center Winston-Salem, North Carolina
Novant Health Zimmer Cancer Institute Wilmington, North Carolina
OhioHealth Columbus, Ohio
Oncology Hematology Care Cincinnati, Ohio
Ondokuz Mayis University Samsun,
Ordensklinikum Linz GmbH Elisabethinen Linz,
Osaka Metropolitan University Hospital Osaka,
Oslo University Hospital HF Ulleval sykehus Oslo,
Ospedale San Raffaele Milan,
Pamukkale University Medical Faculty Denizli,
Peking Union Medical College Hospital Beijing,
Peking University First Hospital Beijing,
Peking University Shenzhen Hospital Shenzhen,
Perlmutter Cancer Center at NYU Langone Health New York, New York
Pratia Onkologia Katowice Katowice,
Princess Alexandra Hospital Woolloongabba, Queensland
Pusan National University Hospital Busan,
Qilu Hospital of Shandong University Jinan,
Rabin Petah Tikva,
Rambam Medical Center Haifa,
Regionshospitalet Godstrup Herning,
Reinier de Graaf Gasthuis Delft,
Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai,
Royal Prince Alfred Hospital Camperdown,
Ruijin Hospital Shanghai Jiao Tong University Shanghai,
SCRI CCCIT gem GmbH Salzburg,
Saitama Medical University Hospital Iruma-gun,
Samodzielny Publiczny Szpital Kliniczny Nr 1 Lublin,
Samsung Medical Center Seoul,
Santa Casa de Misericordia de Belo Horizonte Belo Horizonte,
Seoul National University Hospital Seoul,
Severance Hospital Yonsei University Health System Seoul,
Shaare Zedek Medical Center Jerusalem,
Shanghai Fourth People s Hospital Shanghai,
Sheba Medical Center Ramat Gan,
Shengjing Hospital of China Medical University Shenyang,
Shizuoka Cancer Center Nagaizumi-cho,Sunto-gun,
Sichuan Provincial Peoples Hospital Chengdu,
Sir Charles Gairdner Hospital Perth,
Skanes universitetssjukhus Lund,
Soroka Medical Center Beersheba,
St. Antonius Ziekenhuis Nieuwegein Nieuwegein,
St. Olavs Hospital Trondheim,
Sun Yat -Sen University Cancer Center Guangzhou,
Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach Kielce,
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza Brzozów,
Szpital Uniwersytecki im Karola Marcinkowskiego w Zielonej Gorze Zielona Góra,
Szpital Uniwersytecki nr 2 im. Jana Biziela w Bydgoszczy Bydgoszcz,
Tel Aviv Sourasky Medical Center Tel Aviv,
The Catholic University of Korea Seoul St Mary s Hospital Seoul,
The Christ Hospital Cancer Center Cincinnati, Ohio
The First Affiliated Hospital of Guangxi Medical University Nanning,
The First Affiliated Hospital of Wenzhou Medical University Wenzhou,
The First Affiliated Hospital of Xiamen University Xiamen,
The First Affliated Hospital Of Nanchang University Nanchang,
The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an,
The Second Affiliated Hospital of Zhejiang University Hangzhou,
The Second Xiangya Hospital of Central South Hospital Changsha,
Tianjin Medical University Cancer Institute and Hospital Tianjin,
Tokai University Hospital Kanagawa,
UCSF Fresno Clovis, California
Uls Braga - Hosp. Braga Braga,
Uls Hosp Sao Joao Porto,
Universita Degli Studi di Roma Tor Vergata Roma,
Universitaetsklinik Hamburg-Eppendorf Hamburg,
Universitaetsklinikum Halle Saale Halle,
Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II, Tübingen,
Universitaetsklinikum Wuerzburg Würzburg,
Universitair Ziekenhuis Leuven Leuven,
Universitetssjukhuset Örebro Örebro,
University College London Hospitals London,
University Hospitals Birmingham NHS Foundation Trust Birmingham,
University Hospitals Bristol and Weston Bristol,
University Hospitals Cleveland Medical Center Cleveland, Ohio
University of Arizona Cancer Center Tucson, Arizona
University of Cincinnati Cincinnati, Ohio
University of Connecticut Farmington, Connecticut
University of Illinois Medical Center Chicago, Illinois
University of Iowa Health Care Waukee, Iowa
University of Michigan Ann Arbor, Michigan
University of Nebraska Medical Center Omaha, Nebraska
University of Texas Southwestern Medical Center Dallas, Texas
University of Virginia Charlottesville, Virginia
Uniwersytecki Szpital Kliniczny W Poznaniu Poznan,
Uniwersyteckie Centrum Kliniczne Gdansk,
Utah Cancer Specialists Salt Lake City, Utah
VFN v Praze Prague,
VUmc Amsterdam Amsterdam,
Valkyrie Clinical Trials Los Angeles, California
Vejle Sygehus Vejle,
Virginia Commonwealth University Medical Center Richmond, Virginia
Virginia Oncology Associates Brock Cancer Center Norfolk, Virginia
Weill Cornell Medical College New York, New York
Western General Hospital Edinburgh,
Wojewodzki Szpital Kliniczny w Bialej Podlaskiej Biała Podlaska,
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi Lodz,
Wollongong Hospital Wollongong,
Wuhan Tongji Hospital Tongji Medical College Wuhan,
Yale New Haven Hospital New Haven, Connecticut
Yamagata University Hospital Yamagata,
Yamanashi Prefectural Central Hospital Yamanashi,
ZAS Cadix Antwerp,
Zealand University Hospital Roskilde,
Zhongda Hospital Southeast University Nanjing,
Zuyderland Medical Center Sittard-Geleen,
the First Hospital of Jilin University Changchun,

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) (cAMeLot-2)

Contact(s):

Study Contact - Participate-In-This-Study1@its.jnj.com

Principal Investigator:

System ID: NCT06852222

Show full eligibility criteria

Inclusion criteria: * Be 18 years of age or older at the time of informed consent * Previously untreated lysine N-methyltransferase 2A gene rearranged (KMT2Ar) or nucleophosmin 1 gene mutated (NPM1m) acute myeloid leukemia (AML) with greater than or equal to (\> or =) 10% bone marrow blasts per 2022 international Consensus Classification criteria * Ineligible for intensive chemotherapy based on the following criteria: a) \>= 75 years of age and ineligible per physician's discretion, with Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, b) \>=18 to \<75 years of age with \>= 1 of the following comorbidities: i) ECOG performance status of 2, ii) Severe cardiac disorder, iii) Severe pulmonary disorder, iv) Renal impairment, v) Moderate hepatic impairment vi) Comorbidity that, in the investigator's opinion, makes the participant unsuitable for intensive chemotherapy, which must be documented before enrollment as defined in the protocol. Ineligibility for intensive chemotherapy should be explicitly approved by a multidisciplinary team in countries in which this process is standard of care * Participants must have adequate hepatic and renal function * A female participant must agree not to be pregnant, breast-feed, plan to become pregnant and use protocol-specified contraception while enrolled in this study and for 6 months after the last dose of study treatment * A male participant must agree to use protocol-specified contraception while enrolled in this study for at least 90 days after the last dose of study treatment * Must sign an informed consent form indicating that the participant understands the purpose of, and procedures required for, the study and is willing to participate in the study Exclusion criteria: * Diagnosis of acute promyelocytic leukemia (APL) * Known active leukemic involvement of the central nervous system (CNS) * Recipient of solid organ transplant * Any cardiac disorders such as heart attack, uncontrolled/unstable chest pain, congestive heart failure, uncontrolled or symptomatic irregular heartbeat, blockage of a blood vessel to brain, or transient ischemic (decreased oxygen in tissue) attack within 6 months of randomization * Active infectious hepatitis * Live, attenuated vaccine within 4 weeks of randomization * Known allergies, hypersensitivity, or intolerance of bleximenib, azacitidine, or venetoclax excipients

Interventions: DRUG: Bleximenib, DRUG: Venetoclax (VEN), DRUG: Azacitidine (AZA), DRUG: Placebo

Conditions: Leukemia, Myeloid, Acute

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Study Locations

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Location	Contacts
A O U Sant Orsola Malpighi Bologna,
AHEPA University General Hospital of Thessaloniki Thessaloniki,
ASST Grande Ospedale Metropolitano Niguarda Milan,
ASST Papa Giovanni XXIII Bergamo Bergamo,
AST Pesaro e Urbino Ospedale San Salvatore Pesaro,
AZ Sint-Jan Bruges,
Aalborg University Hospital Aalborg,
Addenbrookes Hospital Cambridge,
Aiiku Hospital Sapporo,
Algemeen Ziekenhuis Delta Roeselare,
Ankara Etlik Sehir Hastanesi Ankara,
Ankara University School of Medicine Cebeci Hospital Ankara,
Arthur J E Child Comprehensive Cancer Centre Calgary, Alberta
Asan Medical Center Seoul,
Atrium Health Charlotte, North Carolina
Atrium Health Wake Forest Baptist Comprehensive Cancer Center Winston-Salem, North Carolina
Azienda Ospedaliera Spedali Civili di Brescia Brescia,
Azienda Ospedaliera di Perugia Ospedale S.Maria della Misericordia Perugia,
Baylor University Medical Center Dallas, Texas
CHRU de Nancy - Hôpitaux de Brabois Vandœuvre-lès-Nancy,
CHU De Nice Hopital De l'Archet Nice,
CHU Lyon Sud Pierre-Bénite,
CHU Reims Hopital Robert Debre Reims,
CHU d'Angers Angers,
CHU de Clermont Ferrand - Site Estaing Clermont-Ferrand,
CHU de Montpellier Hopital Saint Eloi Montpellier,
CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont Montreal, Quebec
Cancer Treatment Center of America Phoenix Goodyear, Arizona
CancerCare Manitoba Winnipeg, Manitoba
Carmel Medical Center Haifa,
Casa Sollievo della Sofferenza IRCCS San Giovanni Rotondo,
Centro de Investigacion Clinica Chapultepec Morelia, Michoacán
Chaim Sheba Medical Center Ramat Gan,
Chi Mei Medical Center Liouying Branch Tainan,
Chu Helora Hospital La Louviere Site Jolimont La Louvière,
Chu Rennes Hopital Pontchaillou Rennes,
Chungnam National University Hospital Daejeon,
City of Hope Duarte, California
Cleveland Clinic Cleveland, Ohio
Cleveland Clinic Florida Weston, Florida
Clinica Univ. de Navarra Pamplona,
Clinica Univ. de Navarra Pamplona,
Clinique Saint Pierre Ottignies,
Colchester Hospital University NHS Colchester,
Dana Farber Cancer Institute Boston, Massachusetts
Dartmouth Hitchcock Medical Center Lebanon, New Hampshire
Derriford Hospital Plymouth,
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital Ankara,
Einstein-Montefiore Medical Center The Bronx, New York
Evaggelismos Hospital Athens,
Fakultni Nemocnice Ostrava Ostrava - Poruba,
Fakultni nemocnice Hradec Kralove Hradec Králové,
Fakultni nemocnice Kralovske Vinohrady Prague,
Fakultni nemocnice Plzen Pilsen,
Fakultní nemocnice Brno, Interní hematologická a onkologická klinika Brno,
First Affiliated Hospital SooChow University Suzhou,
Flinders Medical Centre Bedford Park,
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milan,
Fondazione IRCCS Policlinico San Matteo Pavia,
Fox Chase Cancer Center Philadelphia, Pennsylvania
Fred Hutchinson Cancer Center Seattle, Washington
Fukushima Medical University Hospital Fukushima,
Fundacao Pio XII Barretos,
Gabrail Cancer Center Canton, Ohio
General Hospital of Athens Attikon Chaïdári,
General University Hospital of Patras Rio,
Geniko Nosokomeio Thessalonikis George Papanikolaou Thessaloniki,
Ghent University Hospital Ghent,
Gifu Municipal Hospital Gifu,
Grande Ospedale Metropolitano 'Bianchi-Melacrino-Morelli' Reggio Calabria Reggio Calabria,
Gunmaken Saiseikai Maebashi Hospital Maebashi,
Guys' and St Thomas' NHS Trust London,
Hadassah University Hospita Ein Kerem Jerusalem,
Henan Cancer Hospital Zhengzhou,
Henry Ford Health System Detroit, Michigan
Hopital Saint Louis Paris,
Hopital Saint Vincent de Paul Lille,
Hosp Clinico Univ de Salamanca Salamanca,
Hosp Univ A Coruna A Coruña,
Hosp Univ Vall D Hebron Barcelona,
Hosp. Clinic de Barcelona Barcelona,
Hosp. Quiron Madrid Pozuelo Pozuelo de Alarcón,
Hosp. San Pedro de Alcantara Cáceres,
Hosp. Univ. 12 de Octubre Madrid,
Hosp. Univ. I Politecni La Fe Valencia,
Hosp. Univ. Marques de Valdecilla Santander,
Hosp. Univ. Ramon Y Cajal Madrid,
Hosp. Virgen Del Rocio Seville,
Hosp. de Jerez de La Frontera Jerez de la Frontera,
Hosp. de La Santa Creu I Sant Pau Barcelona,
IRCCS Istituto Clinico Humanitas Rozzano,
Inst. Cat. Doncologia-H Duran I Reynals L'Hospitalet de Llobregat,
Institut Paoli Calmettes Marseille,
Institut Universitaire du Cancer Toulouse Oncopole Toulouse,
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences Tijian,
Instituto D Or de Pesquisa e Ensino Salvador,
Instituto D Or de Pesquisa e Ensino Salvador,
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City, DIF
Instituto Portugues de Oncologia Porto,
Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI) Rio de Janeiro,
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola,
Japanese Red Cross Osaka Hospital Osaka,
Juravinski Cancer Centre Hamilton, Ontario
Kanazawa University Hospital Kanazawa,
Kaohsiung Chang Gung Memorial Hospital Kaohsiung City,
Kent and Canterbury Hospital Canterbury,
Kepler Universitatsklinikum GmbH Linz,
Klinikum Augsburg Augsburg,
Kobe City Medical Center General Hospital Kobe,
Koc University Medical Faculty Istanbul,
Kyushu University Hospital Fukuoka,
Liga Norte Riograndense Contra O Cancer Natal,
Liga Paranaense de Combate ao Cancer Curitiba,
Linkou Chang Gung Memorial Hospital Taoyuan District,
London Health Sciences Centre Victoria Hospital London, Ontario
MD Anderson Cancer Center Houston, Texas
Mary Bird Perkins Cancer Center Baton Rouge, Louisiana
Memorial Antalya Hospital Antalya,
Ministerio da Saude Instituto Nacional do Cancer Rio de Janeiro,
Moffit Cancer Center Tampa, Florida
Nagoya University Hospital Showa-Ku Nagoya,
National Cancer Center Gyeonggi-do,
National Hospital Organization Kumamoto Medical Center Kumamoto,
National Taiwan University Hospital Taipei,
New York Presbyterian - Weill Cornell New York, New York
Nippon Medical School Hospital Tokyo,
Norton Cancer Institute Louisville, Kentucky
Novant Health Winston-Salem, North Carolina
Novant Health Winston-Salem, North Carolina
Odense University Hospital Odense,
Okayama University Hospital Okayama,
Ondokuz Mayis University Samsun,
Ordensklinikum Linz GmbH Elisabethinen Linz,
Orlando Health Cancer Institute Orlando, Florida
Ospedale S. Maria Delle Croci Ravenna,
Peking University First Hospital Beijing,
Peking University People's Hospital Beijing,
Peking University Third Hospital Beijing, Beijing Municipality
Peter MacCallum Cancer Centre Melbourne, Victoria
Princess Alexandra Hospital Woolloongabba, Queensland
Princess Margaret Cancer Centre University Health Network Toronto, Ontario
Providence Oncology and Hematology Care Clinic Westside Portland, Oregon
Providence Portland Medical Center Portland, Oregon
Qilu Hospital of Shandong University Jinan,
Queen Elizabeth II Health Sciences Centre Halifax, Nova Scotia
Queen Mary Hospital Hong Kong,
Rabin Medical Center Petah Tikva,
Rambam Medical Center Haifa,
Real e Benemérita Associação Portuguesa de Beneficência São Paulo,
Roswell Park Comprehensive Cancer Center Buffalo, New York
Royal Prince Alfred Hospital Camperdown,
Sakarya University Training and Research Hospital Sakarya,
Samsung Medical Center Seoul,
Seoul National University Bundang Hospital Seongnam,
Seoul National University Hospital Seoul,
Shaare Zedek Medical Center Jerusalem,
Shamir Medical Center Assaf Harofeh Be’er Ya‘aqov,
Shengjing Hospital of China Medical University Shenyang,
Sichuan Provincial Peoples Hospital Chengdu,
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein São Paulo,
St George Hospital Kogarah, New South Wales
St Vincents Hospital Melbourne Fitzroy,
Sun Yat Sen University Cancer Center Guangzhou,
Swedish Cancer Institute Seattle, Washington
Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach Kielce,
Tel Aviv Sourasky Medical Center Tel Aviv,
The Catholic University of Korea Seoul St Marys Hospital Seoul,
The Clatterbridge Cancer Centre Liverpool,
The First Affiliated Hospital Zhejiang University College of Medicine Hangzhou,
The First Affiliated Hospital of Chongqing Medical University Chongqing, Chongqing Municipality
The First Affiliated Hospital of Guangxi Medical University Nanning,
The First Affiliated Hospital of NanChang University Nanchang,
The First Affiliated Hospital of USTC Anhui Provincial Hospital Hefei,
The First Affiliated Hospital of Wenzhou Medical University Wenzhou,
The First Affiliated Hospital of Xiamen University Xiamen,
The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an,
The Second Hospital & Clinical Medical School Lanzhou University Lanzhou,
The Second People's Hospital of Shenzhen Shenzhen,
The first Affiliated Hospital of Jilin University Changchun,
Thomas Jefferson University Philadelphia, Pennsylvania
Tohoku University Hospital Sendai,
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Bunkyō City,
TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology Wuhan,
UZ Antwerpen Edegem,
Uls Santa Maria Hosp. Santa Maria Lisbon,
Uls Santo Antonio - Hosp. Santo Antonio Porto,
Uls Sao Joao - Hosp. Sao Joao Porto,
Uls Sao Jose - Hosp. Sto Antonio Dos Capuchos Lisbon,
Union Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan,
UniversitaetsKlinikum Heidelberg Heidelberg,
Universitaetsklinikum Carl Gustav Carus TU Dresden Dresden,
Universitaetsklinikum Frankfurt Frankfurt,
Universitaetsklinikum Hamburg Eppendorf Hamburg,
Universitaetsklinikum Leipzig Leipzig,
Universitaetsklinikum Salzburg Landeskrankenhaus Salzburg,
Universitaetsklinikum Schleswig Holstein Campus Kiel Kiel,
Universitair Ziekenhuis Leuven Leuven,
University General Hospital of Ioannina Ioannina,
University Hospital of Alexandroupolis Alexandroupoli,
University Hospitals Cleveland Medical Center Cleveland, Ohio
University Hospitals Sussex NHS Foundation Trust East Sussex,
University Hospitals Sussex NHS Foundation Trust East Sussex,
University of Arkansas at Little Rock Little Rock, Arkansas
University of Chicago Medicine Chicago, Illinois
University of Fukui Hospital Yoshida,
University of Kentucky Markey Cancer Center Lexington, Kentucky
University of Pittsburgh Medical Center Pittsburgh, Pennsylvania
University of Rochester Medical Center Rochester, New York
University of Tennessee Knoxville, Tennessee
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu Wroclaw,
Uniwersytecki Szpital Kliniczny w Bialymstoku Bialystok,
Uniwersyteckie Centrum Kliniczne Gdansk,
UofL Health Brown Cancer Center Louisville, Kentucky
Ustav hematologie a krevni transfuze Prague,
VM Medical Park Mersin Hospital Mersin,
Vancouver General Hospital Vancouver, British Columbia
Vanderbilt Ingram Cancer Center Nashville, Tennessee
Virginia Commonwealth University - Massey Cancer Center Richmond, Virginia
Vseobecna Fakultni Nemocnice Prague,
Washington University in St Louis St Louis, Missouri
West China Hospital Si Chuan University Chengdu,
Western General Hospital Edinburgh,
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi Lodz,
Yamagata University Hospital Yamagata,
Zealand University Hospital Roskilde,
Zhongda Hospital Southeast University Nanjing,
Ziekenhuis Oost-Limburg Genk,

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer (ECHO)

Contact(s):

Maureen A Lemens, BSN - lemens.maureen@mayo.edu

Principal Investigator:

System ID: NCT05051722

Show full eligibility criteria

Inclusion Criteria for Cohort 1: Patients will be ≥45 years of age and meet one of the following criteria: * Abnormal uterine bleeding * Postmenopausal bleeding OR Patients ages 18 - 44 years of age and meet these criteria * Abnormal uterine bleeding * One risk factor for endometrial cancer (BMI ≥30 or PCOS or Tamoxifen use) Exclusion Criteria for Cohort 1: * Prior hysterectomy * Current known pregnancy diagnosis * Any prior pelvic or vaginal radiotherapy * Any prior cancer (except basal cell skin cancer) within the past 5 years * Chemotherapy within the past 5 years * Current biopsy-proven cervical, vaginal, or vulvar cancer or lower genital tract dysplasia * Current biopsy-proven endometrial cancer or endometrial hyperplasia * Current biopsy-proven benign endometrial polyp * Endometrial biopsy/sampling within the preceding 1 month showing benign endometrium Inclusion Criteria for Cohort 2: Patients will be ≥18 years of age and meet at least one of the following criteria: * Presence of biopsy-proven EC (any histology, including uterine carcinosarcoma) and surgical intervention planned. Surgical intervention can include any of the following: hysterectomy, D\&C, hysteroscopic resection * Biopsy showing AEH or EIN with surgical intervention planned. Surgical intervention can include any of the following: hysterectomy, D\&C, hysteroscopic resection, etc) Exclusion Criteria for Cohort 2: * Undergoing surgical procedure for recurrent or metastatic EC * Received preoperative neoadjuvant chemotherapy or radiotherapy for current EC diagnosis * Prior hysterectomy * Current known pregnancy diagnosis * Prior or current biopsy-proven cervical cancer * Presence of concomitant biopsy-proven cervical dysplasia * Any prior pelvic or vaginal radiotherapy * Any prior cancer (except basal cell skin cancer) within the past 5 years * Chemotherapy within the past 5 years * Prior intervention or surgery with intent to completely remove the target pathology Inclusion Criteria for Cohort 3: Patients will be ≥18 years of age, have a cervix and meet at least one of the following criteria: * History of current abnormal cervical/endocervical Pap test for which the patient is presenting for colposcopy * Cervical mass identified on physical exam and patient referred for cervical biopsy, even if colposcopy not recommended or indicated * Planned clinically indicated surgical excisional biopsy or removal of the cervix (cold knife cone, LEEP, hysterectomy) for abnormal Pap test, cervical dysplasia, cervical mass, or biopsy-proven invasive cervical cancer (adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, or less common primary cervical carcinomas all eligible) Exclusion Criteria for Cohort 3: * History of pelvic or vaginal radiotherapy * Prior total hysterectomy (cervix removed) for any indication * Current known pregnancy diagnosis * Cervical mass biopsy-proven to be EC or a cancer metastatic from a non-cervical origin * Any prior cancer (except basal cell skin cancer) within the past 5 years * Chemotherapy within the past 5 years * Patients presenting for colposcopy as part of lower genital tract dysplasia or cancer surveillance after prior curative intent treatment and no current Pap abnormality or cervical mass * Prior intervention or surgery with intent to completely remove the target pathology for the current lesion / diagnosis during the current episode Inclusion Criteria for Cohort 4: Patients will be ≥45 years of age and should meet at least one of the following criteria: * Undergoing hysterectomy with biopsy-proven or clinically presumed (based on imaging and/or clinical symptoms) benign gynecologic or uterine pathology of fibroids, endometriosis, adenomyosis, or benign endometrial polyps. * Undergoing any gynecologic surgery in which a benign pathologic tissue diagnosis of fibroids, endometriosis, adenomyosis, or benign endometrial polyp is anticipated to be confirmed. Exclusion Criteria for Cohort 4: * Endometrial biopsy or office hysteroscopy within 2 weeks preceding the planned gynecologic surgery procedure for fibroids, endometriosis, benign endometrial polyps, or adenomyosis * Any surgery within the past 3 months * Prior hysterectomy * Current known pregnancy diagnosis * Prior or current biopsy-proven gynecologic cancer * Current biopsy-proven AEH/EIN, cervical, vaginal, or vulvar dysplasia * Prior pelvic or vaginal radiotherapy * Any prior cancer (except basal cell skin cancer) within the past 5 years * Chemotherapy within the past 5 years * Undergoing hysterectomy for prolapse without a coexisting known or presumed benign uterine pathologic diagnosis of fibroids, endometriosis, benign endometrial polyps, or adenomyosis * Prior intervention or surgery with intent to completely remove the target pathology for the current lesion / diagnosis during the current episode Inclusion Criteria for Cohort 5: Patients with a uterus will be ≥45 years of age and should meet the following criteria: * Presenting for GYN wellness exam, ± Pap test * No change in medical conditions, new diagnoses, or new medications within the past 6 months Exclusion Criteria for Cohort 5: * Pap test or cervical biopsy within the past 1 month * Endometrial biopsy or office hysteroscopy within the past 1 month * Any surgery within the past 3 months * Prior hysterectomy * Current known pregnancy diagnosis * Prior or current biopsy-proven gynecologic cancer * Current biopsy-proven AEH/EIN, cervical, vaginal, or vulvar dysplasia * Prior pelvic or vaginal radiotherapy * Any prior cancer (except basal cell skin cancer) within the past 5 years * Chemotherapy within the past 5 years * Criteria met for inclusion in any of the other study cohorts Inclusion Criteria for Cohort 6: Patients ≥50 years of age and: * Postmenopausal * At least 1 intact ovary * Diagnosis of an adnexal mass or a clinical suspicion of early-stage ovarian cancer (including fallopian tube cancer) * Planned surgery for the adnexal mass * For vaginal fluid collection, patient must have a uterus, cervix and at least 1 intact fallopian tube\* (without prior tubal ligation/occlusion) Exclusion criteria for Cohort 6: * Any current or prior cancer diagnosis (except basal cell or squamous cell skin cancer, non-gyn) * Chemotherapy for cancer treatment within the past 5 years prior to collection * Clinically suspected advanced stage ovarian cancer (Stage III or IV) on presentation, if known prior to specimen collection * Surgical candidates for recurrent ovarian cancer * History of pelvic or vaginal radiation therapy * Known current synchronous endometrial cancer or hyperplasia * Known current cervical, vaginal, or vulvar dysplasia Inclusion criteria for Cohort 7: Women will be ≥18 years of age and meet the following criteria: * Presence of clinically probable ovarian, fallopian tube, or primary peritoneal cancer (all under the umbrella of OC) based on clinical findings of any/all of the following: imaging showing adnexal and/or abdominal masses consistent with probable ovarian cancer, omental caking, elevated CA125, ascites, imaging-guided biopsy consistent with OC pathology * Newly diagnosed with ovarian, fallopian tube or primary peritoneal cancer without neoadjuvant therapy * At least one intact ovary * For vaginal fluid collection, patient must have a uterus, cervix and at least 1 intact fallopian tube\* (without prior tubal ligation/occlusion) Exclusion criteria for Cohort 7: * Patients with recurrent OC * Any current or prior cancer diagnosis (except basal cell or squamous cell skin cancer, non-gyn) within the past 5 years * Chemotherapy for cancer treatment within the past 5 years prior to collection * History of pelvic or vaginal radiation therapy * Known current synchronous endometrial cancer or hyperplasia * Known current cervical, vaginal, or vulvar dysplasia * Current known pregnancy diagnosis

Interventions: DIAGNOSTIC_TEST: Vaginal Fluid Collection, DIAGNOSTIC_TEST: Blood Collection

Conditions: Endometrial Cancer, Cervical Cancer, Atypical Endometrial Hyperplasia, Cervical Dysplasia, Adnexal Mass, Ovarian Cancer

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Study Locations

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Location	Contacts
Altru Health System Grand Forks, North Dakota	Alexis Tatum, CRC - (atatum@altru.org) Tina Schmitz, BSN - (tkschmitz@altru.org)
Cleveland Clinic Cleveland, Ohio	Tori Carpenter, CRC - (carpent3@ccf.org) Sarah Neale, CRC - (neales@ccf.org)
Genoma Research, Inc. Miami, Florida	Laura Lucia, BHSc, CRC - (lauralucia@genoma.comcastbiz.net)
Mayo Clinic Jacksonville, Florida	Debbie L Ryan, CCRP - (ryan.debra29@mayo.edu)
Mayo Clinic Jacksonville, Florida	Ashley N Shelton, CRC - (Shelton.Ashley@mayo.edu)
Mayo Clinic Jacksonville, Florida	Maureen A Lemens, BSN - (lemens.maureen@mayo.edu)
Mayo Clinic Health System - Northwest Wisconsin Eau Claire, Wisconsin	Stephanie L Larson, ACRC - (larson.stephanie3@mayo.edu) Christina M Scinto, ACRC - (cinto.christina@mayo.edu)
Mayo Clinic Health System - Southwest Wisconsin La Crosse, Wisconsin	Kate L Zboralski, ACRC - (zboralski.kathryn@mayo.edu) Taylor Cammer, ACRC - (cammer.taylor@mayo.edu)
Medical Colleagues of Texas, LLP Katy, Texas	Erika Keller, CRC - (erika.keller@elligodirect.com) Gabriella Coletta, CRC - (gabiella.coletta@elligodirect.com)
Medical College of Wisconsin Milwaukee, Wisconsin	Jayashree Narayanon, CRC - (jnarayan@mcw.edu) Maia Terashvili, Ph.D. - (mterashv@mcw.edu)
My GYN Care Miami, Florida
Ochsner Clinic Foundation New Orleans, Louisiana	Ashley Samuel, CRC - (ashley.samuel@ochsner.org) Veronica Hixon Calliet, BSN - (veronica.hixoncalliet@ochsner.org)
Orlando Health Orlando, Florida	Donya Shahnavaz, CRC - (donya.shahnavaz@orlandohealth.com) Bianca Henry, CRC - (bianca.henry@orlandohealth.com)
Piedmont Healthcare Atlanta, Georgia	Dionne Jean, CRC - (dionne.jean@piedmont.org)
Providea Health Partners, LLC Evergreen Park, Illinois
Sarasota Memorial Health Care System Sarasota, Florida	Rachael Sanacore - (Rachael-Sanacore@smh.com) Megan Swiger - (Megan-Swiger@smh.com)
Signature Women's Healthcare, LLC Pembroke Pines, Florida
The Woman's Health Pavilion Westbury, New York	Monica Martinez, CRC - (mmartinez@ilovemygyn.com)
The Woman's Health Pavilion Westbury, New York	Monica Martinez, CRC - (mmartinez@ilovemygyn.com)
Total Women's Care of the Heights Houston, Texas	Carmen Paz - (carmen.paz@twcheights.com)
University of Chicago Chicago, Illinois	Calla O'Connor, MPH - (calla.oconnor@bsd.uchicago.edu) Veronika Sesari - (vseseri@bsd.uchicago.edu)
University of Mississippi Medical Center Jackson, Mississippi	Tanya Robinson, RN - (trobinson13@umc.edu) Kenna H Nettles, PA-C - (knettles1@umc.edu)
Valley OB-GYN Clinic Saginaw, Michigan	Jacqueline Lang, CCRC - (jacqueline.lang@elligodirect.com)
Virginia Commonwealth University/ Massey Cancer Center Richmond, Virginia	Morgan DeHart - (dehart2@vcu.edu) Faith McFadden, MSN - (mcfaddenfr@vcu.edu)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Contact(s):

Toll Free Number - Trialsites@msd.com

Principal Investigator:

System ID: NCT06890884

Show full eligibility criteria

Inclusion Criteria:

The main inclusion criteria include but are not limited to the following: * Has histologically confirmed diagnosis of germinal center B-cell (GCB) subtype of diffuse large B-cell lymphoma (DLBCL), by prior biopsy, according to the World Health Organization (WHO) classification of neoplasms of the hematopoietic and lymphoid tissues. * Has positron emission tomography (PET) positive disease at screening, defined as 4 to 5 on the Lugano 5-point scale. * Has received no prior treatment for their DLBCL. * Human immunodeficiency virus (HIV) infected participants must have well controlled HIV on antiretroviral therapy (ART). * Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load prior to randomization. * Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening.

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following: * Has a history of transformation of indolent disease to DLBCL. * Has received a diagnosis of primary mediastinal B-cell lymphoma (PMBCL) or Grey zone lymphoma. * Has Ann Arbor Stage I DLBCL. * Has clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (\<6 months prior to enrollment), myocardial infarction (\<6 months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification Class ≥II), or serious cardiac arrhythmia requiring medication. * Has clinically significant pericardial or pleural effusion. * Has ongoing Grade \>1 peripheral neuropathy. * Has a demyelinating form of Charcot-Marie-Tooth disease. * HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease. * Has ongoing corticosteroid therapy. * Known additional malignancy that is progressing or has required active treatment within the past 2 years. * Known active central nervous system (CNS) lymphoma. * Has active autoimmune disease that has required systemic treatment in the past 2 years. * Has active infection requiring systemic therapy. * Has active HBV (defined as HBsAg positive and detectable HBV deoxyribonucleic acid (DNA)) and HCV (defined as anti-HCV antibody positive and detectable HCV ribonucleic acid (RNA)) infection. * Has history of stem cell/solid organ transplant.

Interventions: BIOLOGICAL: Zilovertamab vedotin, BIOLOGICAL: Rituximab, DRUG: Cyclophosphamide, DRUG: Doxorubicin, BIOLOGICAL: Rituximab Biosimilar, DRUG: Prednisone, DRUG: Prednisolone, BIOLOGICAL: Polatuzumab vedotin, DRUG: Rescue Medication

Conditions: Lymphoma, Large B-Cell, Diffuse

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Study Locations

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Location	Contacts
AZ Delta ( Site 0303) Roeselare, West-Vlaanderen
AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0306) Mechelen, Antwerpen
Aichi Cancer Center ( Site 1007) Nagoya, Aichi-ken
Alliance Cancer Specialists (ACS) ( Site 8010) Sellersville, Pennsylvania
Arcispedale Santa Maria Nuova ( Site 0706) Reggio Emilia,
Atlantic Health Morristown Medical Center ( Site 0163) Morristown, New Jersey
Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 0702) Palermo,
Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0703) Alessandria, Ancona
Baptist Health Hardin ( Site 0154) Elizabethtown, Kentucky
Baptist Health Lexington ( Site 0127) Lexington, Kentucky
Beacon Cancer Care ( Site 0142) Post Falls, Idaho
Boca Raton Regional Hospital-Lynn Cancer Institute ( Site 0130) Boca Raton, Florida
Bristol Haematology and Oncology Centre ( Site 0908) Bristol, Bristol, City of
Cancer Care Associates Of York ( Site 0174) York, Pennsylvania
Christie Hospital NHS Trust ( Site 0901) Manchester,
Clatterbridge Cancer Centre - Liverpool ( Site 0911) Liverpool,
Cleveland Clinic - Hillcrest Hospital-Hillcrest Hospital Cancer Center ( Site 0199) Mayfield Heights, Ohio
Cleveland Clinic Main ( Site 0101) Cleveland, Ohio
Clinical Research Alliance ( Site 0122) Westbury, New York
Cliniques Universitaires Saint-Luc ( Site 0302) Brussels, Bruxelles-Capitale, Region de
Edith Wolfson Medical Center ( Site 0602) Holon,
Erie County Medical Center ( Site 0175) Buffalo, New York
Fairview Hospital-Moll Cancer Center ( Site 0198) Cleveland, Ohio
Fujita Health University Hospital ( Site 1003) Toyoake, Aichi-ken
Genesis Cancer and Blood Institute ( Site 0193) Hot Springs, Arkansas
Georgetown University Medical Center ( Site 0117) Washington D.C., District of Columbia
Haddasah Medical Center ( Site 0601) Jerusalem,
Hammersmith Hospital ( Site 0915) London, London, City of
Hokkaido University Hospital ( Site 1004) Sapporo, Hokkaido
Hopital de Jolimont ( Site 0304) Haine-Saint-Paul, Hainaut
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 0707) Meldola, Forli-Cesena
Illinois Cancer Care ( Site 7005) Peoria, Illinois
Infirmary Cancer Care ( Site 0157) Mobile, Alabama
Intermountain Healthcare - St. George ( Site 0203) St. George, Utah
Intermountain Medical Center ( Site 0182) Murray, Utah
Istituto Clinico Humanitas ( Site 0704) Rozzano, Milano
Istituto Europeo di Oncologia ( Site 0701) Milan,
Kansai Medical University Hospital ( Site 1006) Hirakata, Osaka
Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 0108) New York, New York
Lincoln County Hospital ( Site 0906) Lincoln, Lincolnshire
Mater Misercordiae University Hospital ( Site 0501) Dublin,
Medical Oncology Hematology Consultants (MOHC) ( Site 8007) Newark, Delaware
Mid Florida Hematology and Oncology Center ( Site 0152) Orange City, Florida
Mission Blood & Cancer Care ( Site 0114) Waukee, Iowa
Mount Sinai Cancer Center ( Site 0140) Miami Beach, Florida
NHO Revive Research Institute, LLC ( Site 0121) Lincoln, Nebraska
Nagasaki University Hospital ( Site 1008) Nagasaki,
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0803) Warsaw, Masovian Voivodeship
National Cancer Center Hospital ( Site 1009) Chūō, Tokyo
National Hospital Organization Sendai Medical Center ( Site 1005) Sendai, Miyagi
Nippon Medical School Hospital ( Site 1001) Bunkyo, Tokyo
Northwest Cancer Specialists (Compass Oncology) ( Site 8000) Vancouver, Washington
Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0185) Louisville, Kentucky
Our Lady of the Lake Physician Group-Medical Oncology ( Site 0180) Baton Rouge, Louisiana
Palo Verde Cancer Specialists ( Site 0105) Glendale, Arizona
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0208) Mineola, New York
Pratia MCM Krakow ( Site 0804) Karkow, Lesser Poland Voivodeship
Pratia Onkologia Katowice ( Site 0801) Katowice, Silesian Voivodeship
Providence Oncology and Hematology Clinic Westside ( Site 0179) Portland, Oregon
Providence Portland Medical Center ( Site 0120) Portland, Oregon
Rabin Medical Center ( Site 0607) Petah Tikva,
Rambam Health Care Campus ( Site 0604) Haifa,
Rocky Mountain Cancer Centers (RMCC) ( Site 8001) Aurora, Colorado
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0135) Burbank, California
Royal Devon & Exeter Hospital ( Site 0910) Exeter, Devon
SCRI Oncology Partners ( Site 7002) Nashville, Tennessee
SSM Health Dean Medical Group ( Site 0106) Madison, Wisconsin
Saint Elizabeth Medical Center Edgewood ( Site 0141) Edgewood, Kentucky
Sheba Medical Center ( Site 0603) Ramat Gan,
Shimane University Hospital ( Site 1002) Izumo, Shimane
Stoke Mandeville Hospital ( Site 0917) Aylesbury, Buckinghamshire
Szpital Specjalistyczny im. Jedrzeja Sniadeckiego w Nowym Saczu ( Site 0806) Nowy Sącz, Lesser Poland Voivodeship
Tennessee Cancer Specialists ( Site 7004) Knoxville, Tennessee
Texas Oncology - Central/South Texas ( Site 8006) Austin, Texas
Texas Oncology - Northeast Texas ( Site 8002) Tyler, Texas
Texas Oncology - San Antonio ( Site 8009) San Antonio, Texas
Texas Oncology - West Texas ( Site 8008) Amarillo, Texas
The James Cook University Hospital ( Site 0909) Middlesbrough, England
The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0145) Tyler, Texas
UZ Leuven ( Site 0301) Leuven, Vlaams-Brabant
Universita degli Studi di Napoli Federico II ( Site 0705) Napoli,
Universitaetsklinikum Wuerzburg ( Site 0401) Würzburg, Bavaria
University Hospital Limerick ( Site 0503) Limerick,
University Hospitals Plymouth NHS Trust ( Site 0905) Plymouth, Devon
University Of Nebraska Medical Center ( Site 0110) Omaha, Nebraska
University of Chicago Medical Center ( Site 0126) Chicago, Illinois
University of Cincinnati Medical Center ( Site 0156) Cincinnati, Ohio
University of Iowa-Holden Comprehensive Cancer Center ( Site 0139) Iowa City, Iowa
University of North Carolina Medical Center ( Site 0136) Chapel Hill, North Carolina
Uniwersyteckie Centrum Kliniczne ( Site 0802) Gdansk, Pomeranian Voivodeship
VCU Health Adult Outpatient Pavillion ( Site 0138) Richmond, Virginia
Virginia Cancer Specialists, PC ( Site 8003) Manassas, Virginia
ZIV Medical Center ( Site 0605) Safed,

E-Mindfulness Approaches for Living After Breast Cancer (HEAL-ABC)

Contact(s):

Director Regulatory Affairs - langerj@nrgoncology.org

Principal Investigator:

System ID: NCT06748222

Show full eligibility criteria

Inclusion Criteria:

* The participant or a legally authorized representative must provide study-specific informed consent prior to pre-entry and, for participants treated in the U.S., authorization permitting release of personal health information. * The participant must have been greater than or equal to 18 or less than or equal to 50 years of age at the time of breast cancer diagnosis. * The participant must have a first-time diagnosis of non-metastatic breast cancer which is Stage 0, I, II, or III. * The participant must have a score of greater than or equal to 5 and less than or equal to 14 on the Patient Health Questionnaire-8 item (PHQ-8). * Participants must have completed all primary breast cancer treatments at least 6 months prior to and no more than 5 years prior to registration. Note: Primary treatments include surgery, radiation therapy, adjuvant chemotherapy, targeted therapies (e.g., PARP (poly-ADP ribose polymerase) inhibitors, CDK4/6 inhibitors, TDM-1, pertuzumab, or immunotherapy). (Participants may still be taking adjuvant therapy with trastuzumab or adjuvant endocrine therapy or completing minor reconstructive surgery.) * Participant must be able to understand, speak, read, and write in English or Spanish. * Participant must be willing to participate in a 6-week program to receive training in mindfulness. * Participant must be able to use a smartphone, tablet, or other digital device. * Sex assigned at birth must be female.

Exclusion Criteria:

* Patient Health Questionnaire-8 item (PHQ-8) score of less than 5 or greater than 14 . * Any history or current evidence of recurrent or metastatic breast cancer. * Current or past history of another cancer. Participants with a history of only non-melanoma skin cancer or in situ cervical cancer without chemotherapy treatment would be eligible. * Currently pregnant or planning to become pregnant in the near future. * Participants who are enrolled in other cancer control or behavioral intervention trials that require frequent assessments or training activities.

Interventions: BEHAVIORAL: Mindfulness (MAPs) Live Online, BEHAVIORAL: Mindfulness (MAPs) Digital App, BEHAVIORAL: Meditation Only Control Group

Conditions: Breast Cancer, Depression

Keywords: Breast Cancer, Mindfulness, Meditation, Digital

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Study Locations

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Location	Contacts
AIS Cancer Center at San Joaquin Community Hospital Bakersfield, California
Adams Cancer Center Gettysburg, Pennsylvania
Addison Gilbert Hospital Gloucester, Massachusetts
Allegiance Health Jackson, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Annie Penn Memorial Hospital Reidsville, North Carolina	Site Public Contact - (stacey.phelps@conehealth.com)
Armes Family Cancer Center Findlay, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Aspirus Cancer Care - James Beck Cancer Center Rhinelander, Wisconsin	Site Public Contact - (Beth.Knetter@aspirus.org)
Aspirus Cancer Care - Stevens Point Stevens Point, Wisconsin	Site Public Contact - (Beth.Knetter@aspirus.org)
Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids, Wisconsin
Aspirus Medford Hospital Medford, Wisconsin	Site Public Contact - (Beth.Knetter@aspirus.org)
Aspirus Regional Cancer Center Wausau, Wisconsin
Bayshore Community Hospital Holmdel, New Jersey	Site Public Contact - (Roster@nrgoncology.org)
Beaufort Memorial Hospital Beaufort, South Carolina	Site Public Contact - (kwade@bmhsc.org)
Beverly Hospital Beverly, Massachusetts
Blanchard Valley Hospital Findlay, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Bon Secours Memorial Regional Medical Center Mechanicsville, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Richmond Community Hospital Richmond, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Saint Francis Medical Center Midlothian, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
Bon Secours Saint Mary's Hospital Richmond, Virginia	Site Public Contact - (anne_carmellat@bshsi.org)
CHI Health Good Samaritan Kearney, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Cancer Care Center of O'Fallon O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Carle Cancer Center Urbana, Illinois	Site Public Contact - (Research@carle.com)
Carle Cancer Institute Normal Normal, Illinois	Site Public Contact - (Research@Carle.com)
Carle Physician Group-Effingham Effingham, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois	Site Public Contact - (Research@carle.com)
Carle at The Riverfront Danville, Illinois	Site Public Contact - (Research@Carle.com)
Central Maryland Radiation Oncology in Howard County Columbia, Maryland
Centro Comprensivo de Cancer de UPR San Juan,	Site Public Contact - (Roster@nrgoncology.org)
Chester County Hospital West Chester, Pennsylvania
Cone Health Cancer Center Greensboro, North Carolina	Site Public Contact - (stacey.phelps@conehealth.com)
Cone Health Cancer Center at Alamance Regional Burlington, North Carolina	Site Public Contact - (stacey.phelps@conehealth.com)
Cone Health Cancer Center at Drawbridge Parkway Greensboro, North Carolina	Site Public Contact - (stacey.phelps@conehealth.com)
Cone Health MedCenter Asheboro Asheboro, North Carolina	Site Public Contact - (stacey.phelps@conehealth.com)
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Reed City Hospital Reed City, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Cotton O'Neil Cancer Center / Stormont Vail Health Topeka, Kansas
Crossroads Cancer Center Effingham, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Eisenhower Medical Center Rancho Mirage, California
Emory Decatur Hospital Decatur, Georgia	Site Public Contact - (clinicaltrialsoncology@dekalbmedical.org)
Emory Saint Joseph's Hospital Atlanta, Georgia
Emory University Hospital Midtown Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute Atlanta, Georgia
Ephrata Cancer Center Ephrata, Pennsylvania
Essentia Health Cancer Center Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Flaget Memorial Hospital Bardstown, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Fremont - Rideout Cancer Center Marysville, California
Geisinger Cancer Center Dickson City Dickson City, Pennsylvania	Site Public Contact - (hemoncctrials@geisinger.edu)
Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Center Danville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Gene Upshaw Memorial Tahoe Forest Cancer Center Truckee, California
Glens Falls Hospital Glens Falls, New York
Goshen Center for Cancer Care Goshen, Indiana	Site Public Contact - (cccois@goshenhealth.com)
Grady Health System Atlanta, Georgia
Gundersen Lutheran Medical Center La Crosse, Wisconsin	Site Public Contact - (cancerctr@gundersenhealth.org)
Heartland Regional Medical Center Saint Joseph, Missouri	Site Public Contact - (Trisha.England2@mymlc.com)
Henry Ford Cancer Institute-Downriver Brownstown, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Hospital Detroit, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Medical Center-Columbus Novi, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford West Bloomfield Hospital West Bloomfield, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Illinois CancerCare - Washington Washington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Bloomington Bloomington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Canton Canton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Carthage Carthage, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Dixon Dixon, Illinois
Illinois CancerCare-Eureka Eureka, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Galesburg Galesburg, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Macomb Macomb, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Pekin Pekin, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peoria Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peru Peru, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Princeton Princeton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Indu and Raj Soin Medical Center Beavercreek, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Iowa Methodist Medical Center Des Moines, Iowa
Jersey Shore Medical Center Neptune City, New Jersey
Kaiser Permanente Downtown Commons Sacramento, California	Site Public Contact - (kpoct@kp.org)
Kaiser Permanente Dublin Dublin, California
Kaiser Permanente Fresno Orchard Plaza Fresno, California
Kaiser Permanente Medical Center - Santa Clara Santa Clara, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente Medical Center-Vacaville Vacaville, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii	Site Public Contact - (shelley.a.clark@kp.org)
Kaiser Permanente Northwest Portland, Oregon	Site Public Contact - (information@kpchr.org)
Kaiser Permanente San Leandro San Leandro, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente- Marshall Medical Offices Redwood City, California
Kaiser Permanente-Deer Valley Medical Center Antioch, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Fremont Fremont, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Fresno Fresno, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Modesto Modesto, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Oakland Oakland, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Richmond Richmond, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Roseville Roseville, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-San Francisco San Francisco, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Santa Rosa Santa Rosa, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Santa Teresa-San Jose San Jose, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-South Sacramento Sacramento, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-South San Francisco South San Francisco, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Stockton Stockton, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Vallejo Vallejo, California	Site Public Contact - (Kpoct@kp.org)
Kaiser Permanente-Walnut Creek Walnut Creek, California	Site Public Contact - (Kpoct@kp.org)
Kaiser San Rafael-Gallinas San Rafael, California	Site Public Contact - (Kpoct@kp.org)
Kettering Medical Center Kettering, Ohio	Site Public Contact - (clinical.trials@daytonncorp.org)
Lahey Hospital and Medical Center Burlington, Massachusetts	Site Public Contact - (lhmc-cancer-clinical-trials@lahey.org)
Lahey Medical Center-Peabody Peabody, Massachusetts	Site Public Contact - (lhmc-cancer-clinical-trials@lahey.org)
Lake Regional Hospital Osage Beach, Missouri	Site Public Contact - (clinicaltrials@lakeregional.com)
Langlade Hospital and Cancer Center Antigo, Wisconsin	Site Public Contact - (Juli.Alford@aspirus.org)
Licking Memorial Hospital Newark, Ohio	Site Public Contact - (Jeffh@columbusccop.org)
Lowell General Hospital Lowell, Massachusetts	Site Public Contact - (ghincks@lowellgeneral.org)
Marshall Cancer Center Cameron Park, California	Site Public Contact - (cancerservices@marshallmedical.org)
Maryland Proton Treatment Center Baltimore, Maryland	Site Public Contact - (info@mdproton.com)
Mayo Clinic Health System-Eau Claire Clinic Eau Claire, Wisconsin
Mayo Clinic Health System-Franciscan Healthcare La Crosse, Wisconsin
Mayo Clinic Health Systems-Mankato Mankato, Minnesota
Mayo Clinic Hospital in Arizona Phoenix, Arizona
Mayo Clinic in Florida Jacksonville, Florida
Mayo Clinic in Rochester Rochester, Minnesota
MedStar Franklin Square Medical Center/Weinberg Cancer Institute Baltimore, Maryland
MedStar Good Samaritan Hospital Baltimore, Maryland	Site Public Contact - (Barbara.rector@medstar.net)
MedStar Southern Maryland Hospital Center Clinton, Maryland
Medstar Washington Hospital Center Washington D.C., District of Columbia
Memorial Hospital Chattanooga, Tennessee	Site Public Contact - (Jeffh@columbusccop.org)
Memorial Hospital of South Bend South Bend, Indiana
Memorial Hospital of Sweetwater County Rock Springs, Wyoming	Site Public Contact - (tharris@sweetwatermemorial.com)
Mercy Health - Perrysburg Hospital Perrysburg, Ohio	Site Public Contact - (Jeffh@columbusccop.org)
Mercy Health - Saint Anne Hospital Toledo, Ohio	Site Public Contact - (Jeffh@columbusccop.org)
Mercy Hospital Fort Smith Fort Smith, Arkansas
Mercy Hospital South St Louis, Missouri	Site Public Contact - (Danielle.Werle@mercy.net)
Mercy Hospital Springfield Springfield, Missouri
Mercy Medical Center - Des Moines Des Moines, Iowa	Site Public Contact - (cancerresearch@mercydesmoines.org)
Mount Carmel East Hospital Columbus, Ohio	Site Public Contact - (Jeffh@columbusccop.org)
Mount Carmel Grove City Hospital Grove City, Ohio	Site Public Contact - (Jeffh@columbusccop.org)
Mount Sinai Chelsea New York, New York	Site Public Contact - (CCTO@mssm.edu)
Mount Sinai Hospital New York, New York	Site Public Contact - (CCTO@mssm.edu)
Mount Sinai Queens Astoria, New York	Site Public Contact - (CCTO@mssm.edu)
Mount Sinai Union Square New York, New York	Site Public Contact - (CCTO@mssm.edu)
Mount Sinai West New York, New York	Site Public Contact - (CCTO@mssm.edu)
Munson Medical Center Traverse City, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
MyMichigan Medical Center Alpena Alpena, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Gladwin Gladwin, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Gratiot Alma, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Midland Midland, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Mount Pleasant Mount Pleasant, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Saginaw Saginaw, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
MyMichigan Medical Center Tawas Tawas City, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Northwestern Medicine Cancer Center Delnor Geneva, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Cancer Center Kishwaukee DeKalb, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois	Site Public Contact - (Donald.Smith3@nm.org)
Northwestern Medicine Glenview Outpatient Center Glenview, Illinois
Northwestern Medicine Grayslake Outpatient Center Grayslake, Illinois
Northwestern Medicine Lake Forest Hospital Lake Forest, Illinois	Site Public Contact - (cancertrials@northwestern.edu)
Northwestern Medicine Oak Brook Oak Brook, Illinois	Site Public Contact - (nctnprogram_rhlccc@northwestern.edu)
Northwestern Medicine Orland Park Orland Park, Illinois	Site Public Contact - (nctnprogram_rhlccc@northwestern.edu)
Northwestern University Chicago, Illinois	Site Public Contact - (cancer@northwestern.edu)
Ocean University Medical Center Brick, New Jersey
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa
PROncology San Juan,	Site Public Contact - (info@PRoncology.com)
Prisma Health Cancer Institute - Butternut Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Easley Easley, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Eastside Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Faris Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Greer Greer, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Seneca Seneca, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
ProHealth D N Greenwald Center Mukwonago, Wisconsin	Site Public Contact - (research.institute@phci.org)
ProHealth Oconomowoc Memorial Hospital Oconomowoc, Wisconsin
Providence Medical Foundation - Santa Rosa Santa Rosa, California
Reading Hospital West Reading, Pennsylvania
Redeemer Health Meadowbrook, Pennsylvania
Riverview Medical Center/Booker Cancer Center Red Bank, New Jersey
Rush MD Anderson Cancer Center Chicago, Illinois	Site Public Contact - (Cancer_Studies@rush.edu)
Rush MD Anderson Cancer Center at Rush Oak Park Oak Park, Illinois	Site Public Contact - (Cancer_Studies@rush.edu)
Rush-Copley Healthcare Center Yorkville, Illinois	Site Public Contact - (Cancer.Research@rushcopley.com)
Rush-Copley Medical Center Aurora, Illinois	Site Public Contact - (RCMC_Cancer_Research@rush.edu)
SIH Cancer Institute Carterville, Illinois	Site Public Contact - (clinical.research@sih.net)
SSM Health Good Samaritan Mount Vernon, Illinois	Site Public Contact - (gayla.hall@ssmhealth.com)
Saint Ann's Hospital Westerville, Ohio	Site Public Contact - (Jeffh@columbusccop.org)
Saint Anthony Regional Hospital Carroll, Iowa	Site Public Contact - (sbenson@iora.org)
Saint Charles Health System Bend, Oregon	Site Public Contact - (nosall@stcharleshealthcare.org)
Saint Charles Health System-Redmond Redmond, Oregon
Saint Joseph Hospital East Lexington, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin	Site Public Contact - (WI_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls, Wisconsin	Site Public Contact - (WI_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Salinas Valley Memorial Salinas, California	Site Public Contact - (tnielsen2@svmh.com)
Sechler Family Cancer Center Lebanon, Pennsylvania	Site Public Contact - (doxenberg@wellspan.org)
Sinai Hospital of Baltimore Baltimore, Maryland
Southern Illinois University School of Medicine Springfield, Illinois
Southern Ocean County Medical Center Manahawkin, New Jersey
Springfield Clinic Springfield, Illinois
Summit Health - Florham Park Campus Florham Park, New Jersey	Site Public Contact - (mmackenzie@summithealth.com)
Summit Medical Group Berkeley Heights, New Jersey	Site Public Contact - (Roster@nrgoncology.org)
Tallahassee Memorial HealthCare Tallahassee, Florida
The Don and Sybil Harrington Cancer Center Amarillo, Texas	Site Public Contact - (Gina.Cravey@bsahs.org)
The Valley Hospital - Luckow Pavilion Paramus, New Jersey	Site Public Contact - (clinicaltrialsresearch@valleyhealth.com)
ThedaCare Cancer Care - Berlin Berlin, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - New London New London, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Oshkosh Oshkosh, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Shawano Shawano, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Waupaca Waupaca, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Regional Cancer Center Appleton, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Regional Medical Center - Neenah Neenah, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
Tidelands Georgetown Memorial Hospital Georgetown, South Carolina	Site Public Contact - (broe@tidelandshealth.org)
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
UF Health Cancer Institute - Gainesville Gainesville, Florida	Site Public Contact - (cancer-center@ufl.edu)
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa
UI Healthcare Mission Cancer and Blood - Pella Pella, Iowa	Site Public Contact - (trials@missioncancer.com)
UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie, Maryland
UM Capital Region Medical Center Largo, Maryland	Site Public Contact - (Sarah.Larson@umm.edu)
UM Saint Joseph Medical Center Towson, Maryland	Site Public Contact - (Jeanmarie.downing@umm.edu)
UM Upper Chesapeake Medical Center Bel Air, Maryland
UW Cancer Center at ProHealth Care Waukesha, Wisconsin	Site Public Contact - (Chanda.miller@phci.org)
University Medical Center New Orleans New Orleans, Louisiana	Site Public Contact - (emede1@lsuhsc.edu)
University of Cincinnati Cancer Center-UC Medical Center Cincinnati, Ohio	Site Public Contact - (cancer@uchealth.com)
University of Cincinnati Cancer Center-West Chester West Chester, Ohio	Site Public Contact - (cancer@uchealth.com)
University of Iowa Healthcare Cancer Services Quad Cities Bettendorf, Iowa	Site Public Contact - (katherine-daprile@uiowa.edu)
University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa
University of Maryland Shore Medical Center at Easton Easton, Maryland	Site Public Contact - (Christina.weisenborn@umm.edu)
University of Maryland/Greenebaum Cancer Center Baltimore, Maryland
University of Michigan Health - Sparrow Lansing Lansing, Michigan	Site Public Contact - (harsha.trivedi@umhsparrow.org)
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma	Site Public Contact - (ou-clinical-trials@ouhsc.edu)
VCU Massey Cancer Center at Stony Point Richmond, Virginia	Site Public Contact - (ctoclinops@vcu.edu)
VCU Massey Comprehensive Cancer Center Richmond, Virginia	Site Public Contact - (CTOclinops@vcu.edu)
Valley Health System Ridgewood Campus Ridgewood, New Jersey	Site Public Contact - (clinicaltrialsresearch@valleyhealth.com)
Vanderbilt Breast Center at One Hundred Oaks Nashville, Tennessee
WellSpan Health-York Cancer Center York, Pennsylvania
WellSpan Medical Oncology and Hematology Hanover, Pennsylvania
William E Kahlert Regional Cancer Center/Sinai Hospital Westminster, Maryland
Women and Infants Hospital Providence, Rhode Island

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