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4 Study Matches
Initial Feasibility Study to Treat Borderline Resectable Pancreatic Cancer With a Planar LDR Source (CivaSheet)
Carra Castagnero - ccastagnero@civatechoncology.com
Fields, Emma, C
NCT02843945
HM20010844
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Inclusion Criteria:
* • Subject signed inform consent
* Age \> 18 years
* Not pregnant or breast feeding
* Patient capable of undergoing anesthesia
* Patient selected to undergo Whipple procedure or distal pancreatectomy
* Patient does not have metastatic disease
* Patients will have close margins
* No prior radiation therapy to the region for separate cancer
* Confirmed diagnosis of borderline resectable or locally advanced pancreatic adenocarcinoma
* Patient Received neoadjuvant chemoradiation (4-10 weeks prior to surgery)
* Chemotherapy was administered for 2-6 cycles with any combination of the following agents:
* Gemcitabine + nb-paclitaxel
* FOLFIRINOX
* Neoadjuvant Chemoradiation was administered as IMRT or 3DCRT (up to 56 Gy), or SBRT (up to 36 Gy) with Pre-operative External beam dose (NCCN)
* up to 56 Gy (1.8-2.0 Gy per fractions) with concurrent gemcitabine, capecitabine, or infusional 5-fluorouracil
Exclusion Criteria:
* Not surgical candidate
* Any other invasive cancer in the past 5 years, except basal cell or squamous cell skin cancer
* An IRE candidate (IRE is Percutaneous irreversible electroporation)
* Recurrent or previously resected tumors
* Documented History of Alcoholism and or drug abuse
* Participant in other clinical trials DEVICE: Directional Brachytherapy Source Implant
Pancreatic Cancer
brachytherapy, CivaSheet, CivaTech, whipple, radiation, borderline resectable, locally advanced, Pd-103, intraoperative radiation
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See this study on ClinicalTrials.gov
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Study Locations
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| Location | Contacts |
|---|---|
| Advocate Christ Medical Center Oak Lawn, Illinois | Colleen Valenti, OCN - (colleen.valenti@advocatehealth.com) |
| Fox Chase Cancer Center Philadelphia, Pennsylvania | |
| Rush University Cancer Center Chicago, Illinois | |
| Tampa General Hospital Tampa, Florida | Raegen Einsmann - (reinsmann@usf.edu) |
| University Medical Center LSU New Orleans, Louisiana | |
| Virginia Commonwealth University Massey Cancer Center Richmond, Virginia |
Pancreatic Cancer Early Detection Consortium (PRECEDE)
Naveen Fawas, BS - naveen.fawaz@arborresearch.org
NCT04970056
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Inclusion Criteria:
Individuals from the following groups who present for clinical evaluation and assessment of PDAC risk at any of the participating sites can be offered participation in the PRECEDE database:
Cohort 1
Individuals without history of PDAC meeting any of the following criteria:
• 2+ relatives with PDAC on same side of family where 2 affected are first degree related to each other and at least 1 affected is first degree related to subject; age 50+ or ≤10 years younger than earliest PDAC in family at time of diagnosis.
• 2 affected first degree relatives with PDAC; age 50+ or 10 years younger than earliest PDAC in family
• BRCA1, BRCA2, PALB2, ATM, MLH1, MSH2, MSH6, PMS2, EPCAM pathogenic or likely pathogenic variant AND 1 first or second degree relative with PDAC; age 50+ or 10 years younger than earliest PDAC in family
• Familial Atypical Moles and Malignant Melanoma (FAMMM) with pathogenic or likely pathogenic CDKN2A variant; age 40+
• Peutz-Jegher syndrome with STK11 pathogenic or likely pathogenic variant; age 35+
• Hereditary pancreatitis with PRSS1 pathogenic or likely pathogenic variant and history of pancreatitis; age 40+ Cohort 2 Individuals without history of PDAC meeting any of the following criteria:
• ATM, BRCA1, BRCA2, or PALB2 pathogenic or likely pathogenic variant regardless of family history, age 50+
• 2+ relatives with PDAC on the same side of family, any degree of relation, not meeting other criteria above; age 50+ or 10 years younger than earliest PDAC in family
• 1 first degree relative with PDAC ≤ age 45; age up to 10 years younger than PDAC diagnosis in family member Cohort 3 Individual meeting criteria for Cohorts 1 or 2 EXCEPT age (i.e. too young to qualify for Cohorts 1 or 2) Cohort 4 Individuals without history of PDAC presenting for evaluation who do not meet any criteria for 1-3, 6, or the Cyst Cohort. Cohort 5 Individuals without history of PDAC who are not otherwise engaged in pancreas surveillance at a participating site may be invited to participate in the PRECEDE database and to donate a biosample (e.g. blood, saliva, and/or buccal swab) for discovery studies. This may include relatives of individuals in Cohorts 1-4,6, and the Cyst Cohort. Cohort 6a Individuals diagnosed with PDAC or pancreatic high-grade dysplasia after enrollment in PRECEDE meeting any of the following criteria:
• Family history includes at least one first degree relative with PDAC, or 2 relatives with PDAC who are first degree related to each other
• Personal or family history of a pathogenic or likely pathogenic germline variant in ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2,PMS2, PRSS1, STK11 Cohort 6b Individuals with a personal history of PDAC or pancreatic high-grade dysplasia meeting any of the following criteria:
• Family history includes at least one first degree relative with PDAC, or 2 relatives with PDAC who are first degree related to each other
• Personal or family history of a pathogenic or likely pathogenic germline variant in ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2,PMS2, PRSS1, STK11
• Diagnosed ≤ age 45 Cohort 6c Individuals with newly diagnosed early stage (stage I or stage II) PDAC seen at a PRECEDE site that do not meet the criteria for 6a or 6b. Cohort 6d Individuals with PDAC seen at a PRECEDE site that do not meet the criteria for 6a, 6b, or 6c. Cyst Cohort Individuals with a personal history of a pancreatic cystic neoplasm not meeting any criteria for Cohorts 1-3 or 6 (no known family history of PDAC, no known pathogenic germline variants linked to PDAC risk)
Exclusion Criteria:
* Individuals not meeting the criteria above. Pancreas Cancer, Pancreas Cyst, Pancreatic Ductal Adenocarcinoma, Genetic Predisposition
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Study Locations
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| Location | Contacts |
|---|---|
| Azienda Ospedaliera Universitaria Integrata Verona Verona, | Salvatore Paiella - (salvatore.paiella@univr.it) Erica Secchettin - (erica.secchettin@univr.it) |
| Beaumont/Corewell Health Royal Oak, Michigan | Tara Rangarajan - (tara.rangarajan@corewellhealth.org) |
| British Columbia Cancer Agency Vancouver, British Columbia | Eugene Cheung - (eugene.cheung1@bccancer.bc.ca) |
| Cedars-Sinai Medical Center Los Angeles, California | Jenny Frisendahl - (jenny.frisendahl@cshs.org) |
| City of Hope Duarte, California | Diamond Ward - (diward@coh.org) |
| Columbia University Irving Medical Center New York, New York | Katharine Godfrey - (kb3217@cumc.columbia.edu) |
| Emory University Hospital Atlanta, Georgia | Halley Fowler - (halley.fowler@emory.edu) |
| Epworth Healthcare Richmond, Victoria | Ashleigh Poh - (ashleigh.poh@epworth.org.au) |
| Fox Chase Cancer Center Philadelphia, Pennsylvania | Eberechukwu Muoneke - (eberechukwu.muoneke@fccc.edu) |
| Hackensack Meridian Health Hackensack, New Jersey | Christianna Torres - (christianna.torres@hmhn.org) |
| Hoag Newport Beach, California | Alexandria Adams - (alexandria.adams@hoag.org) Zulma Loera - (zulma.loera@hoag.org) |
| Honor Health Research Institute Scottsdale, Arizona | Jeanette Dupree - (jdupree@honorhealth.com) |
| Hospital Clinic de Barcelona Barcelona, | Eva Vaquero - (evaquero@clinic.cat) |
| Hospital Universitari Arnau de Vilanova Lleida, Lerida | Xavier Molero - (xmolero@gss.cat) |
| Huntsman Cancer Institute Salt Lake City, Utah | Jo Lyman - (jo.anson@hci.utah.edu) |
| Icahn School of Medicine at Mount Sinai New York, New York | Joyce Serebrenik - (joyce.serebrenik@mountsinai.org) Storey Harbison - (storey.harbison@mssm.edu) |
| Illinois CancerCare Peoria, Illinois | Carrie Geoffroy - (cgeoffroy@illinoiscancercare.com) |
| Inova Schar Cancer Institute Fairfax, Virginia | Salman Baig - (Salman.Baig@inova.org) |
| Intermountain Health Salt Lake City, Utah | |
| Landspitali University Hospital Reykjavik, | Jóhanna Stefansdottir - (johanste@landspitali.is) |
| MD Anderson Center Houston, Texas | |
| Massachusetts General Hospital Boston, Massachusetts | Danielle Lynch - (dlynch22@mgh.harvard.edu) |
| Mayo Clinic Arizona Phoenix, Arizona | Michele Richardson - (richardson.michele@mayo.edu) |
| Mayo Clinic Jacksonville Jacksonville, Florida | Christian Glover - (glover.christian@mayo.edu) |
| McGill University Health Centre Montreal, Quebec | Adeline Cuggia - (pancreas.surveillance@muhc.mcgill.ca) |
| Memorial Sloan Kettering Cancer Center New York, New York | Jeffin Naduparambil - (naduparj@mskcc.org) |
| Moffitt Cancer Center Tampa, Florida | Toni Basinski - (Toni.Basinski@Moffitt.Org) |
| National Cancer Centre Singapore Singapore, | Caitlin Nicole - (caitlin.nicole.s.v@nccs.com.sg) Meggie Huang Mochao - (meggie.huang.m.c@nccs.com.sg) |
| National Cheng Kung University Hospital (NCKUH) Tainan, Taiwan T.o.c. | Yung-Yeh Su - (yysu@nhri.edu.tw) |
| National Taiwan University Hospital Taipei, | Wei-Chih David Liao - (david.ntuh@gmail.com) |
| NorthShore University Healthsystem Evanston, Illinois | Aram Rojas - (arojas@northshore.org) |
| Oregon Health & Science University Portland, Oregon | Dove Keith - (keithd@ohsu.edu) |
| Providence Health and Services Burbank, California | Taridu Ekanayake - (emtaridu.ekanayake@providence.org) |
| Ramón y Cajal University Hospital Madrid, | Julie Earl - (julie.earl@live.co.uk) |
| Semmelweis University, Institute of Pancreatic Diseases Budapest, | Zoltán Hajnády - (hajnady.zoltan@semmelweis.hu) |
| Sheba Medical Center Ramat Gan, | Maria Raitses - (Maria.RaitsesGurevich@sheba.health.gov.il) |
| The Ohio State University Columbus, Ohio | Ashley Tyson - (Ashley.Tyson@osumc.edu) |
| The University of Texas Southwestern Medical Center Dallas, Texas | |
| UC Davis Sacramento, California | Tanpreet Dodd - (tkdodd@health.ucdavis.edu) |
| UC Irvine Health Orange, California | Blake Johnson - (blakej@hs.uci.edu) |
| UC San Diego Moores Cancer Center La Jolla, California | Emma Vail - (e2brooks@health.ucsd.edu) |
| UCLA Health Los Angeles, California | Sophia Quiroz - (SStokes@mednet.ucla.edu) |
| UMass Memorial Medical Center Worcester, Massachusetts | Paige Malone - (paige.malone@umassmed.edu) |
| University Health Network Toronto, Ontario | Spring Holter - (spring.holter@uhn.ca) |
| University of California, San Francisco (UCSF) San Francisco, California | Kurt Giles - (PancreasCRC@ucsf.edu) |
| University of Chicago Medicine Chicago, Illinois | Nia Howard - (nia.howard@bsd.uchicago.edu) |
| University of Kansas Medical Center Kansas City, Kansas | Jodi Claybaugh - (jclaybaugh@kumc.edu) |
| University of Liverpool Liverpool, | Annabelle Boughey - (europac@liverpool.ac.uk) |
| University of Miami Miami, Florida | Casper Ruiz Ruiz - (cxr1353@med.miami.edu) |
| University of Michigan Ann Arbor, Michigan | Sarah Volk - (stomanic@med.umich.edu) Erika Koeppe - (eskoeppe@med.umich.edu) |
| University of Nebraska Medical Center Omaha, Nebraska | Suzanne Wessling - (suzanne.wessling@unmc.edu) |
| University of Pennsylvania Philadelphia, Pennsylvania | Danny Clay - (Daniel.Clay@Pennmedicine.upenn.edu) |
| University of Pittsburgh Medical Center (UPMC) Pittsburgh, Pennsylvania | Beth Dudley - (dudleyre@upmc.edu) |
| University of Rochester Medical Center Rochester, New York | Chelsea DiBella - (chelsea_dibella@urmc.rochester.edu) |
| University of Tennessee Graduate School of Medicine Knoxville, Tennessee | Tiffany Johnson - (thjohnson@utmck.edu) |
| University of Virginia Charlottesville, Virginia | Evelyn Garcia - (ev4pd@uvahealth.org) |
| University of Washington Seattle, Washington | Lisa Ann Lai - (lail@uw.edu) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Faith McFadden - (mcfaddenfr@vcu.edu) |
| White Plains Hospital White Plains, New York | Griselda Cruz - (grcruz@wphospital.org) |
| Yale University New Haven, Connecticut | Scott Merenda - (scott.merenda@yale.edu) |
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
Pfizer CT.gov Call Center - ClinicalTrials.gov_Inquiries@pfizer.com
NCT06989437
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Key inclusion Criteria:
* Signed Informed Consent Document
* Documented active diagnosis of metastatic pancreatic ductal adenocarcinoma
* Cachexia defined by Fearon criteria of weight loss
* Completed 1 x 28-day cycle of first-line systemic nab-paclitaxel and gemcitabine chemotherapy or 2 x 14-day cycles of FOLFIRINOX chemotherapy and prior to receiving Cycle 2 chemotherapy
* ECOG PS ≤1 with life expectancy of at least 4 months
Key
Exclusion Criteria:
* Current active reversible causes of decreased food intake
* Cachexia caused by other reasons
* Any prior or current clinical diagnosis of heart failure, irrespective of left ventricular ejection fraction or New York Heart Association classification
* Left ventricular ejection fraction \<50%
* Receiving tube feedings or parenteral nutrition at the time of Screening or Randomization
* History of allergic or anaphylactic reaction to any therapeutic or diagnostic monoclonal antibody
* History of allergy or hypersensitivity to any of the chemotherapeutics or any of their excipients
* Neuroendocrine (carcinoid, islet cell) or acinar pancreatic carcinoma, symptomatic brain metastasis, leptomeningeal disease or other active CNS metastases
* Inadequate liver function
* Renal disease requiring dialysis or eGFR \<30 mL/min/1.73m2 DRUG: ponsegromab, DRUG: placebo
Cachexia, Metastatic Pancreatic Ductal Adenocarcinoma
pancreatic cancer, metastatic cancer, cancer, anorexia, cachexia, weight loss, loss of appetite, fatigue
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Show 230 locations
Study Locations
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| Location | Contacts |
|---|---|
| AZ Turnhout - Campus Sint-Elizabeth Turnhout, Antwerpen | |
| Addenbrooke's Hospital Cambridge, Cambridgeshire | |
| Affiliated Hospital of Hebei University Baoding, | |
| Aichi Cancer Center Hospital Nagoya, Aichi-ken | |
| Anhui Provincial Hospital Hefei, | |
| Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde" Guadalajara, Jalisco | |
| Apotheke am Universitätsklinikum Leipzig Leipzig, Saxony | |
| Arthur J.E. Child Comprehensive Cancer Centre Calgary, Alberta | |
| Asan Medical Center Seoul, | |
| Atlantic Health System / Morristown Medical Center Morristown, New Jersey | |
| Atlantic Health System / Overlook Medical Center Summit, New Jersey | |
| Azienda Ospedaliera Universitaria Careggi Florence, Tuscany | |
| Azienda Ospedaliera Universitaria Ospedali Riuniti - Foggia Foggia, | |
| Azienda Ospedaliero Universitaria delle Marche Ancona, | |
| Baylor Scott & White Vasicek Cancer Treatment Center Temple, Texas | |
| Beijing Tsinghua Changgung Hospital Beijing, | |
| CARTI Cancer center Little Rock, Arkansas | |
| CHA Bundang Medical Center, CHA University Seongnam-si, Kyǒnggi-do | |
| CIUSSS- saguenay-Lac-Saint-Jean Chicoutimi, Quebec | |
| Cancer Care Specialists of Illinois Decatur, Illinois | |
| Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon O'Fallon, Illinois | |
| Cancer Hospital Chinese Academy of Medical Science Langfang, Hebei | |
| Cancer Hospital Chinese Academy of Medical Science Langfang, Hebei | |
| Cardiology Associates, Inc ‘Aiea, Hawaii | |
| Cedars-Sinai Cancer at Cedars-Sinai Medical Center Los Angeles, California | |
| Central Arkansas Radiation Therapy Institute, dba CARTI Pine Bluff, Arkansas | |
| Central Arkansas Radiation Therapy Institute, dba CARTI Pine Bluff, Arkansas | |
| Central Arkansas Radiation Therapy Institute, dba CARTI Pine Bluff, Arkansas | |
| Central Arkansas Radiation Therapy Institute, dba CARTI Pine Bluff, Arkansas | |
| Centre Hospitalier Universitaire de Poitiers Poitiers, Vienne | |
| Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre Greenfield Park, Quebec | |
| Centro de Atención e Investigación Cardiovascular del Potosí S.C. San Luis Potosí City, | |
| Centro de Investigacion Clinica de Oaxaca Oaxaca City, Oaxaca | |
| Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine, California | |
| Chiba Cancer Center Chiba, Chiba | |
| China Medical University Hospital Taichung, TW | |
| Chittaranjan National Cancer Institute Kolkata, West Bengal | |
| Cliniques Universitaires Saint-Luc Brussels, | |
| Decatur Memorial Hospital Decatur, Illinois | |
| Fakultna Nemocnica Trnava Trnava, Trnava Region | |
| Fakultna nemocnica Trencin Trenčín, Trenčín Region | |
| Fakultna nemocnica s poliklinikou Nove Zamky Nové Zámky, | |
| Fred Hutchinson Cancer Center Seattle, Washington | |
| Froedtert Hospital and the Medical College of Wisconsin Milwaukee, Wisconsin | |
| Fujian Cancer Hospital Fuzhou, Fujian | |
| Georgetown University Medical Center Washington D.C., District of Columbia | |
| Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy Washington D.C., District of Columbia | |
| Grand Hopital de Charleroi Charleroi, Hainaut | |
| Guangdong General Hospital Guangzhou, | |
| Gustave Roussy Villejuif, X | |
| Guy's & St Thomas' NHS Foundation Trust London, | |
| H.R.U Málaga - Hospital General Málaga, | |
| Hadassah Medical Center Jerusalem, | |
| Hammersmith Hospital London, | |
| Henri Mondor Hospital Créteil, Val-de-marne | |
| Henry-Joyce Cancer Clinic Nashville, Tennessee | |
| Hope and Healing Clinical Research LLC Hinsdale, Illinois | |
| Hope and Healing Clinical Research LLC New Lenox- Research Department New Lenox, Illinois | |
| Hospital Clinic de Barcelona Barcelona, | |
| Hospital General Universitario Gregorio Marañon Madrid, | |
| Hospital Moinhos de Vento Porto Alegre, Rio Grande do Sul | |
| Hospital Santa Rita de Cassia Vitória, Espírito Santo | |
| Hospital Universitari Vall d'Hebron Barcelona, | |
| Hospital Universitario Central de Asturias Oviedo, Principality of Asturias | |
| Hospital Universitario Ramon y Cajal Madrid, | |
| Houston Methodist Hospital Houston, Texas | |
| Huzhou Central Hospital Huzhou, | |
| Hôpital Universitaire Paul Brousse Villejuif, | |
| ICON Cancer Centre - Kurralta Park Kurralta Park, South Australia | |
| Icahn School of Medicine at Mount Sinai New York, New York | |
| Icesp - Instituto Do Câncer Do Estado de São Paulo São Paulo, | |
| Icon Cancer Centre Hobart Hobart, Tasmania | |
| Inha University Hospital Jemulpo-gu, Incheon | |
| Inje University Haeundae Paik Hospital Busan, | |
| Institut Jules Bordet Brussels, | |
| Institut Paoli-Calmettes Marseille, | |
| Invision, LLC Honolulu, Hawaii | |
| JHU Oncology Central Kit Services Baltimore, Maryland | |
| Jack & Sheryl Morris Cancer Center New Brunswick, New Jersey | |
| Jewish General Hospital Montreal, Quebec | |
| Johns Hopkins Hospital Baltimore, Maryland | |
| Kagawa University Hospital Kita-gun, | |
| Kanagawa Cancer Center Yokohama, | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung City, | |
| Keimyung University Dongsan Hospital Daegu, Taegu-kwangyǒkshi | |
| Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie Leipzig, Saxony | |
| Klinikum rechts der Isar der Technischen Universitat Munchen München, | |
| Kyushu University Hospital Fukuoka, Fukuoka, | |
| Levine Cancer Institute Charlotte, North Carolina | |
| Liga Norte Riograndense Contra O Cancer Natal, Rio Grande do Norte | |
| MHAT - Sveta Sofia EOOD Sofia, | |
| MHAT for Women's Health Nadezhda Sofia, | |
| Massey Cancer Center Clinical & Translational Research Lab Richmond, Virginia | |
| Mayo Clinic Rochester, Minnesota | |
| Mayo Clinic Rochester, Minnesota | |
| Mayo Clinic Cancer Center Outpatient Pharmacy Rochester, Minnesota | |
| Mayo Clinic Hospital Phoenix, Arizona | |
| Mayo Clinic Pharmacy Jacksonville, Florida | |
| Medical Center Futuremeds Plovdiv, | |
| MidAmerica Cancer Care - American Oncology Partners Kansas City, Missouri | |
| MidAmerica Cancer Care- American Oncology Partners Merriam, Kansas | |
| Muenchen Klinik Neuperlach, Klinik fuer Haematologie und Onkologie München, Bavaria | |
| Narodny Onkologicky Ustav Bratislava, | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie Warsaw, Masovian Voivodeship | |
| National Cancer Center Hospital Chūōku, | |
| National Cancer Center Hospital East Kashiwa, Chiba | |
| National Cheng Kung University Hospital Tainan, | |
| National Hospital Organization Kyushu Cancer Center Fukuoka, | |
| National Taiwan University Hospital Taipei, | |
| Nebraska Medicine Omaha, Nebraska | |
| Nebraska Medicine - Village Pointe Omaha, Nebraska | |
| Nemocnica s poliklinikou Stefana Kukuru Michalovce, a.s. Michalovce, | |
| Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda Milan, Milan | |
| OHSU Center for Health & Healing 1 Portland, Oregon | |
| OSHU Center for Health and Healing 2 Portland, Oregon | |
| Oncocentro Belo Horizonte, Minas Gerais | |
| Oncology Investigational Drug Service (IDS) Baltimore, Maryland | |
| Oregon Health and Science University Portland, Oregon | |
| Pan American Center for Oncology Trials, LLC San Juan, | |
| Pan American Center for Oncology Trials, LLC San Juan, | |
| Pan American Center for Oncology Trials, LLC - Dorado Office Dorado, | |
| Pan American Center for Oncology Trials, LLC - Mayaguez Office Mayagüez, | |
| Peking Union Medical College Hospital Beijing, | |
| Premier Imaging Kansas City, Missouri | |
| Princess Margaret Cancer Centre - University Health Network Toronto, Ontario | |
| Providence Medical Foundation Santa Rosa, California | |
| Qilu Hospital of Shandong University Jinan, Shandong | |
| RWJ University Hospital Somerset, Steeplechase Cancer Center Somerville, New Jersey | |
| Rabin Medical Center Petah Tikva, Central District | |
| Rajiv Gandhi Cancer Institute And Research Centre New Delhi, National Capital Territory of Delhi | |
| Rambam Health Care Campus Haifa, Heifa | |
| Renown Health Medical Oncology Reno, Nevada | |
| Renown Office of Clinical Research Reno, Nevada | |
| Renown Regional Medical Center Reno, Nevada | |
| Royal Free Hospital London, | |
| Royal Marsden Hospital (Chelsea) London, | |
| Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai, Shanghai Municipality | |
| Rutgers Cancer Institute New Brunswick, New Jersey | |
| Rwj University Hospital Somerset Somerville, New Jersey | |
| Samsung Medical Center Seoul, | |
| Sana Klinikum Lichtenberg Berlin, | |
| Sawai Man Singh Medical College Hospital (SMS Hospital) Jaipur, Rajasthan | |
| Second Hospital of Lanzhou University Lanzhou, Gansu | |
| Seoul National University Bundang Hospital Seongnam, Kyeonggi-do | |
| Seoul National University Hospital Seoul, | |
| Severance Hospital, Yonsei University Health System Seoul, | |
| Shaare Zedek Medical Center Jerusalem, | |
| Shanghai General Hospital Shanghai, | |
| Sheba Medical Center Ramat Gan, | |
| Shizuoka Cancer Center Nagaizumi-chō, | |
| Shoalhaven District Memorial Hospital Nowra, New South Wales | |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland | |
| Sir Run Run Shaw Hospital of Zhejiang University School of Medicine Hangzhou, Zhejiang | |
| Sourasky Medical Center Tel Aviv, | |
| Specjalistyczny Szpital Onkologiczny NU-MED Sp. z o.o. Tomaszów Mazowiecki, | |
| St. Joseph Medical Center Kansas City, Missouri | |
| St. Marianna University Hospital Kawasaki-shi, | |
| Sunnybrook Research Institute Toronto, Ontario | |
| Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko - Mazurskim Centrum Onkologii w Olsztynie Olsztyn, Warmian-Masurian Voivodeship | |
| Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie Koszalin, | |
| Taipei Veterans General Hospital Taipei, | |
| Tata Memorial Hospital Mumbai, Maharashtra | |
| The Cancer Institute Hospital of JFCR Koto-ku, Tokyo | |
| The Catholic Univ. of Korea Seoul St. Mary's Hospital Seoul, Seoul-teukbyeolsi [seoul] | |
| The Clatterbridge Cancer Centre Liverpool, | |
| The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang | |
| The First Affiliated Hospital of Xi'An Jiaotong University Xi'an, Shaanxi | |
| The First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan | |
| The First Hospital of Shanxi Medical University Taiyuan, Shanxi | |
| The Kirklin Clinic of UAB Hospital Birmingham, Alabama | |
| The Ottawa Hospital - General Campus Ottawa, Ontario | |
| The Second Hospital of Dalian Medical University Dalian, Liaoning | |
| The University of Alabama at Birmingham Birmingham, Alabama | |
| The University of Hong Kong-Shenzhen Hospital Shenzhen, Guangdong | |
| The University of Osaka Hospital Suita-shi, | |
| UC Irvine Health Orange, California | |
| UC San Diego Koman Family Outpatient Pavilion La Jolla, California | |
| UC San Diego McGrath Outpatient Pavilion - Hillcrest San Diego, California | |
| UC San Diego Medical Center - Bankers Hill San Diego, California | |
| UC San Diego Medical Center - Encinitas Encinitas, California | |
| UC San Diego Medical Center - Hillcrest San Diego, California | |
| UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) La Jolla, California | |
| UC San Diego Medical Center - Rancho Bernardo San Diego, California | |
| UC San Diego Medical Center - Vista Vista, California | |
| UC San Diego Moores Cancer Center La Jolla, California | |
| UC San Diego Sulpizio Cardiovascular Center La Jolla, California | |
| UCI Health - Irvine Irvine, California | |
| UCLA Department of Medicine - Hematology/Oncology Los Angeles, California | |
| UCLA Hematology/Oncology - Santa Monica Santa Monica, California | |
| UNC Hospitals, The University of North Carolina at Chapel Hill Chapel Hill, North Carolina | |
| UZ Leuven Leuven, Vlaams-Brabant | |
| United Imaging Consultants Lenexa, Kansas | |
| Unity Health Toronto, St. Michael's Hospital Toronto, Ontario | |
| Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden Dresden, Saxony | |
| Universitaetsklinikum Duesseldorf Düsseldorf, North Rhine-Westphalia | |
| University Cancer & Blood Center, LLC Athens, Georgia | |
| University Hospital,Kyoto Prefectural University of Medicine Kyoto, | |
| University Multiprofile Hospital for Active Treatment Sofiamed Sofia, | |
| University of Hawaii Cancer Center Honolulu, Hawaii | |
| University of Kentucky Healthcare - Markey Cancer Center Lexington, Kentucky | |
| University of Kentucky Medical Center Lexington, Kentucky | |
| University of Kentucky Research Foundation Lexington, Kentucky | |
| University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO) Lexington, Kentucky | |
| University of Nebraska Medical Center Omaha, Nebraska | |
| University of North Carolina Hospitals at Hillsborough Hillsborough, North Carolina | |
| University of Rochester Medical Center Rochester, New York | |
| University of Texas Southwestern Medical Center Dallas, Texas | |
| University of Texas Southwestern Medical Center - Simmons Cancer Center Dallas, Texas | |
| University of Texas Southwestern Medical Center-WIlliam P. Clements Jr. University Hospital Dallas, Texas | |
| University of Texas Southwestern Medical Center-Zale Lipshy University Hospital Dallas, Texas | |
| University of Washington Medical Center Seattle, Washington | |
| Universität Leipzig - Med. Fakultät Leipzig, Saxony | |
| Uniwersytecki Szpital Kliniczny W Poznaniu Poznan, | |
| VCU Health Short Pump Pavilion Richmond, Virginia | |
| VCU Health Stony Point Richmond, Virginia | |
| VCU Health Tappahannock Hospital Tappahannock, Virginia | |
| VCU Medical Center Gateway Building Richmond, Virginia | |
| Vardhman Mahavir Medical College and Safdarjung Hospital New Delhi, National Capital Territory of Delhi | |
| Venkateshwar Hospital New Delhi, National Capital Territory of Delhi | |
| Virginia Commonwealth University Richmond, Virginia | |
| Virginia Commonwealth University Richmond, Virginia | |
| Virginia Mason Medical Center Seattle, Washington | |
| Vychodoslovensky Onkologicky ustav a.s. Košice, | |
| Wakayama Medical University Hospital Wakayama, | |
| Wakayama Minami Radiology Clinic Wakayama-shi Kimiidera 870-2, Wakayama | |
| Western General Hospital Edinburgh, | |
| Western Health-Sunshine & Footscray Hospitals St Albans, Victoria | |
| Westmead Hospital Westmead, New South Wales | |
| Yamaguchi University Hospital Yamaguchi, Ube, | |
| Zhongshan Hospital Fudan University Shanghai, |
The Vanguard Study: Testing a New Way to Screen for Cancer
ctrrecruit@vcu.edu
NCT06995898
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Inclusion Criteria:
* Ages 45-75 years old
* Agree to provide blood samples for possible MCD testing at enrollment and at 1 year following enrollment
* Agree to allow collection of information from their medical records for study-related purposes
* Understand and be able to complete informed consent and participant questionnaires in English, Spanish, or Arabic
* Note: Eligibility for Spanish and Arabic languages are at the Hub's discretion
Exclusion Criteria:
* Solid malignant tumor or blood cancer diagnosis, with or without treatment, within the last 5 years
* Note: Persons with a history of in situ cancers (e.g., ductal carcinoma in situ of the breast, cervical cancer in situ, atypical melanocytic hyperplasia or melanoma in situ) or nonmelanoma skin cancer are eligible. Persons with a history of prostate cancer that has not been treated are not eligible, regardless of when the diagnosis occurred
* Ongoing cancer diagnostic work-up
* Ongoing participation in another study of an investigational cancer screening test or technology not currently utilized in routine clinical practice
* Currently breastfeeding or pregnant, or planning to become pregnant in the next year
* History of solid organ or hematopoietic transplantation at any time, or blood transfusion within the last 30 days PROCEDURE: Biospecimen Collection, DEVICE: Device Usage, OTHER: Electronic Health Record Review, PROCEDURE: Multi-Cancer Detection Test, PROCEDURE: Multi-Cancer Detection Test, OTHER: Questionnaire Administration
Bladder Carcinoma, Breast Carcinoma, Colorectal Carcinoma, Esophageal Carcinoma, Gastric Carcinoma, Liver Carcinoma, Lung Carcinoma, Malignant Solid Neoplasm, Ovarian Carcinoma, Pancreatic Carcinoma, Prostate Carcinoma
I'm interested
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Show 45 locations
Study Locations
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| Location | Contacts |
|---|---|
| Cancer Care and Hematology-Fort Collins Fort Collins, Colorado | Site Public Contact - (ctsucontact@westat.com) |
| CoxHealth South Hospital Springfield, Missouri | |
| Durham VA Medical Center Durham, North Carolina | Site Public Contact - (VHADURcancertrials@va.gov) |
| Henry Ford Cancer Institute-Downriver Brownstown, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Health Center - Brownstown Brownstown, Michigan | Site Public Contact - (CDUDAS1@hfhs.org) |
| Henry Ford Health Center - Chesterfield Chesterfield, Michigan | Site Public Contact - (CDUDAS1@hfhs.org) |
| Henry Ford Hospital Detroit, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Medical Center Sterling Heights, Michigan | Site Public Contact - (ctsucontact@westat.com) |
| Henry Ford Medical Center - Detroit Northwest Detroit, Michigan | Site Public Contact - (kkeenan1@hfhs.org) |
| Henry Ford Medical Center - Livonia Livonia, Michigan | Site Public Contact - (kkeenan1@hfhs.org) |
| Henry Ford Medical Center - Plymouth Plymouth, Michigan | Site Public Contact - (kkeenan1@hfhs.org) |
| Henry Ford Medical Center - Royal Oak Royal Oak, Michigan | Site Public Contact - (kkeenan1@hfhs.org) |
| Henry Ford Medical Center - Troy Troy, Michigan | Site Public Contact - (kkeenan1@hfhs.org) |
| Henry Ford Medical Center-Columbus Novi, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Medical Center-Cottage Grosse Pointe Farms, Michigan | |
| Henry Ford Medical Center-Fairlane Dearborn, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford West Bloomfield Hospital West Bloomfield, Michigan | Site Public Contact - (CTOResearch@hfhs.org) |
| Henry Ford Wyandotte Hospital Wyandotte, Michigan | Site Public Contact - (nhay@hfhs.org) |
| Inova Fair Oaks Hospital Fairfax, Virginia | Site Public Contact - (Stephanie.VanBebber@inova.org) |
| Inova Schar Cancer Institute Fairfax, Virginia | Site Public Contact - (Stephanie.VanBebber@inova.org) |
| Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii | Site Public Contact - (shelley.a.clark@kp.org) |
| Kaiser Permanente-Division of Research Pleasanton, California | |
| Kaiser Permanente-Franklin Denver, Colorado | Site Public Contact - (KPCOIHRClinicalResearch@kp.org) |
| Kaiser Permanente-Lone Tree Lone Tree, Colorado | Site Public Contact - (KPCOIHRClinicalResearch@kp.org) |
| Kaiser Permanente-Rock Creek Lafayette, Colorado | Site Public Contact - (KPCOIHRClinicalResearch@kp.org) |
| Keefe Memorial Hospital Cheyenne Wells, Colorado | Site Public Contact - (cmillsap@keefemh.org) |
| Louis Stokes Cleveland VA Medical Center Cleveland, Ohio | Site Public Contact - (holly.henry@va.gov) |
| Madigan Army Medical Center Tacoma, Washington | Site Public Contact - (melissa.a.forouhar.mil@health.mil) |
| Medical Center of the Rockies Loveland, Colorado | |
| Minneapolis VA Medical Center Minneapolis, Minnesota | |
| Naval Medical Center - Portsmouth Portsmouth, Virginia | |
| Poudre Valley Hospital Fort Collins, Colorado | |
| Saint Luke's Hospital of Kansas City Kansas City, Missouri | Site Public Contact - (aroland@kccop.org) |
| Sentara Martha Jefferson Hospital Charlottesville, Virginia | |
| Sentara Norfolk General Hospital Norfolk, Virginia | |
| UCHealth Greeley Hospital Greeley, Colorado | Site Public Contact - (ctsucontact@westat.com) |
| UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina | Site Public Contact - (cancerclinicaltrials@med.unc.edu) |
| University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma | Site Public Contact - (ou-clinical-trials@ouhsc.edu) |
| VCU Community Memorial Health Center South Hill, Virginia | Site Public Contact - (nemer.elmouallem@vcuhealth.org) |
| VCU Massey Cancer Center at Stony Point Richmond, Virginia | Site Public Contact - (ctoclinops@vcu.edu) |
| VCU Massey Comprehensive Cancer Center Richmond, Virginia | Site Public Contact - (CTOclinops@vcu.edu) |
| Walter Reed National Military Medical Center Bethesda, Maryland | |
| Washington University School of Medicine St Louis, Missouri | Site Public Contact - (info@siteman.wustl.edu) |
| Zablocki Veterans Administration Medical Center Milwaukee, Wisconsin |