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21 Study Matches
Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention (PROSe-ICD)
Katherine Wu, MD - kwu@jhmi.edu
NCT00733590
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Inclusion Criteria:
* History of acute MI at least 4 weeks old
* Non-ischemic LV dysfunction for at least 9 months
* Who have an ejection fraction (EF) \< or = to 35%
* Undergone elective replacement indicator (ERI) generator replacement of an FDA-approved ICD for primary prevention of SCD within 24 months of enrollment.
* Who have primary prevention implants.
Exclusion Criteria:
* ICD generator replacement for secondary prevention
* Inability or unwillingness to provide valid informed consent
* New York Heart Association Class IV heart failure
* Patients with pre-existing Class 1 indications for pacemaker therapy. Heart Failure, Congestive, Death, Sudden, Cardiac, Arrhythmia, Cardiomyopathies
defibrillator, implanted, genomics, electrocardiography, electrophysiological study, proteomics
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Study Locations
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| Location | Contacts |
|---|---|
| Johns Hopkins University School Of Medicine Baltimore, Maryland | Katherine Wu, MD - (kwu@jhmi.edu) |
| University of Maryland Medical Center Baltimore, Maryland | Stephen R Shorofsky, MD, PhD - (Sshorofs@medicine.umaryland.edu) |
| Virginia Commonwealth University School of Medicine Richmond, Virginia | Kenneth Ellenbogen, MD - (kellenbogen@pol.net) |
| Washington Hospital Center Washington D.C., District of Columbia | Zayd Eldadah, MD, PhD - (Zayd.Eldadah@Medstar.Net) |
A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants
OHB Contact - CMO@Oakhillbio.com
Rozycki, Henry
NCT03253263
HM20016299
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Inclusion Criteria:
• Written informed consents and/or assents must be signed and dated by the participant's parent(s) prior to any study related procedures. The informed consent and any assents for underage parents must be approved by the IRB/IEC (in accordance with local regulations).
• Written informed consents and/or assents must be signed and dated by the participant's birth mother prior to providing study-related information related to birth mother medical history, pregnancy and the birth of the participant. The informed consent and any assents for underage birth mothers must be approved by the IRB/IEC (in accordance with local regulations).
• Subjects must be between 23 weeks +0 days and 27 weeks +6 days GA, inclusive.
Exclusion Criteria:
• Detectable major (or severe) congenital malformation identified before randomization.
• Known or suspected chromosomal abnormality, genetic disorder, or syndrome, identified before randomization, according to the investigator's opinion.
• Hypoglycemia at Baseline (blood glucose less than (\<) 45 milligrams per deciliter \[mg/dL\] or 2.5 milli moles per liter \[mmol/L\]) which persists in spite of glucose supplementation, to exclude severe congenital abnormalities of glucose metabolism.
• Clinically significant neurological disease identified before randomization according to cranial ultrasound (hemorrhages confined to the germinal matrix are allowed) and investigator's opinion.
• Any other condition or therapy that, in the investigator's opinion, may pose a risk to the participant or interfere with the participant's potential compliance with this protocol or interfere with interpretation of results.
• Current or planned participation in a clinical study of another investigational study treatment, device, or procedure (participation in non-interventional studies is permitted on a case-by-case basis).
• The participant or participant's parent(s) is/are unable to comply with the protocol or is unlikely to be available for long-term follow-up as determined by the investigator.
• Birth mother with active COVID-19 infection at birth or a history of severe COVID-19 infection (requiring intensive care hospitalization) during pregnancy.
• Birth mother with known HIV or hepatitis (B, C, or E) infection.
DRUG: OHB-607
Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity, Intraventricular Hemorrhage, Retinopathy of Prematurity (ROP)
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Study Locations
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| Location | Contacts |
|---|---|
| Academisch Medisch Centrum Amsterdam Amsterdam-Zuidoost, North Holland | |
| Arkansas Children's Hospital Little Rock, Arkansas | |
| Ashford and St. Peter's Hospitals NHS Trust - St. Peter's Hospital Chertsey, Surrey | |
| Azienda Ospedaliera Di Padova Padova, | |
| Azienda Ospedaliero-Universitaria Careggi SOD Neonatologia e Terapia Intensiva Neonatale Florence, | |
| Boston Children's Hospital Boston, Massachusetts | |
| Centro Hospitalar Lisboa Lisbon, | |
| Centro Materno Infantil do Norte - Centro Hospital Universitario do Porto, E.P.E. Porto, | |
| Chelsea and Westminster NHS Trust London, | |
| Children's Hospital of Orange County Orange, California | |
| Children's Minnesota - Children's Hospital and Clinics Saint Paul, Minnesota | |
| Children's Minnesota - Children's Hospital and Clinics - St. Paul Saint Paul, Minnesota | |
| Cork University Maternity Hospital Cork, Wilton | |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milan, | |
| Fondazione Policlinico Universitario A Gemelli Roma, Emilia-Romagna | |
| Groupe Hospitalier Necker Enfants Malades Paris, | |
| Hopital Antoine Beclere Clamart, Hauts-de-Seine | |
| Hospital Garcia de Orta Almada, | |
| Hospital General Universitario Dr. Balmis Alicante, | |
| Istituto Giannina Gaslini-Istituto Pediatrico di Ricovero e Genova, | |
| Jackson Memorial Hospital Miami, Florida | |
| Kagoshima City Hospital Kagoshima, Kagoshima-ken | |
| Karolinska Solna Stockholm, | |
| Klinikum Nürnberg Nuremberg, | |
| Kurashiki Central Hospital Kurashikishi, Okayama-ken | |
| LAC USC Medical Center Los Angeles, California | |
| Liverpool Women's Hospital - PPDS Liverpool, | |
| Maastricht University Medical Center Maastricht, | |
| Maria Fareri Children's Hospital Valhalla, New York | |
| Mater Misericordiae Limited Brisbane, | |
| Maternidade Alfredo da Costa Lisbon, | |
| Medical University of South Carolina Children Hospital Charleston, South Carolina | |
| Memorial Hospital of South Bend South Bend, Indiana | |
| Mount Sinai Hospital New York, New York | |
| Nagano Children's Hospital Azumino, Nagano | |
| National Center for Child Health and Development Tokyo, Setagaya-ku, | |
| Nationwide Children's Hospital Columbus, Ohio | |
| Norfolk and Norwich University Hospital Norwich, Norfolk | |
| Norton Children's Hospital Louisville, Kentucky | |
| Ochsner Baptist Medical Center New Orleans, Louisiana | |
| Osaka Women's and Children's Hospital Izumi, Ôsaka | |
| Oulun Yliopistollinen Sairaala Oulu, | |
| Presidio Ospedaliero Di Treviso Ca' Foncello Treviso, | |
| Riley Hospital for Children Indianapolis, Indiana | |
| Royal Hospital for Women Randwick, New South Wales | |
| Royal Women's Hospital Parkville, | |
| Sainte Justine Hospital Montreal, Quebec | |
| Saitama Medical Center Saitama, | |
| Saitama Prefectural Children's Medical Center Saitama, Saitama | |
| Showa Medical University Hospital Tokyo, | |
| Skanes universitetssjukhus Lund, | |
| St. Mary's Hospital Manchester, | |
| Tampa General Hospital Tampa, Florida | |
| Texas Children's Hospital Houston, Texas | |
| Tokyo Metropolitan Children's Medical Center Tokyo, | |
| Tufts Medical Center Boston, Massachusetts | |
| US Davis Sacramento, California | |
| UT Health Science Center San Antonio, Texas | |
| UVA Children's Hospital Charlottesville, Virginia | |
| Universitatsklinikum Freiburg Freiburg im Breisgau, | |
| Universitatsklinikum Leipzig Leipzig, | |
| University College London London, | |
| University Hospital Coventry Coventry, | |
| University of Arkansas for Medical Sciences Little Rock, Arkansas | |
| University of Cambridge Cambridge, | |
| University of Illinois at Chicago Chicago, Illinois | |
| University of Mississippi Medical Center Jackson, Mississippi | |
| University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma | |
| University of Rochester Rochester, New York | |
| Virginia Commonwealth University - Children's Hospital of Richmond at VCU Richmond, Virginia | |
| Westmead Hospital Westmead, New South Wales | |
| Wilhelmina Children Hospital-University Medical Center Utrecht Utrecht, |
Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan (TREAT-HF)
Massey CTO CPC Team - masseycpc@vcu.edu
Bottinor, Wendy
NCT05194111
HM20023601
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Inclusion Criteria:
* Age \/=40% on echocardiogram or cardiac magnetic resonance imaging (MRI)
* No symptoms of heart failure (shortness of breath, fatigue, swelling). Ordinary physical activity does not cause undue fatigue, palpitation, dyspnea (shortness of breath).
Exclusion Criteria:
* -Age \<18 years
* Inability to obtain consent from patient or legally authorized representative
* Active acute or chronic psychiatric illness that in the opinion of the investigator may prevent compliance with study instructions
* Limited English or Spanish proficiency that in the opinion of the investigator may prevent understanding the content of the informed consent form or safely completing the study procedures
* Participation in another concurrent intervention study within 30 days or treatment with an investigational drug within 5 half-lives prior to randomization
* Greater than mild mitral or aortic valve regurgitation/stenosis known pre-cancer therapy
* Severe kidney disease (glomerular filtration rate (GFR) \<30 milliliters (mL)/minute (min)/1.73 meters squared (m2))
* Chronic hyperkalemia (\>5millimoles per liter (mmol/L))
* Evidence of Coronavirus (COVID-19) within the last 60 days or recent (21 days) exposure to close personal contact with COVID-19.
* Greater than moderate tricuspid or pulmonary valve regurgitation/stenosis known pre-cancer therapy
* Hemodynamically significant congenital heart disease in the opinion of the investigator (not including patent foramen ovale (PFO)/small atrial septal defect (ASD) or small ventricular septal defect (VSD))
* Greater than moderate pericardial effusion
* Constrictive cardiomyopathy diagnosed pre-cancer therapy
* Family history of genetic cardiomyopathy
* Evidence of infiltrative cardiomyopathy
* Symptomatic heart disease based on New York Heart Association (NYHA) classification
* Allergy to valsartan or sacubitril
* Inability to complete cardiac magnetic resonance (CMR) or 6-minute walk test
* Inability to measure non-invasive blood pressure and heart rate in the ambulatory/home setting
* Pregnant/lactating
* History of severe hypersensitivity reactions to gadolinium-based contrast agents (will perform limited cardiac imaging without contrast)
* Concomitant use of other angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs), aliskiren, non-steroidal anti-inflammatories (NSAIDs) or lithium or the inability to stop these medications for the study DRUG: Sacubitril-valsartan, DRUG: Valsartan, DRUG: Carvedilol
Heart Failure, Heart Dysfunction
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Study Locations
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| Location | Contacts |
|---|---|
| Virginia Commonwealth University Richmond, Virginia | Massey CTO CPC Team - (masseycpc@vcu.edu) |
Quality of Pediatric Resuscitation in a Multicenter Collaborative (pediRES-Q)
Vinay Nadkarni, MD, MS - nadkarni@chop.edu
NCT02708134
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Inclusion Criteria:
* Patient received chest compressions for at least 1 minute
* Patient between gestational age ≥37 weeks and 18 years of age
Exclusion Criteria:
* Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event Cardiac Arrest, Cardiopulmonary Arrest
Chest compressions, Cardiopulmonary Resuscitation, Pediatric
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Study Locations
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| Location | Contacts |
|---|---|
| Aichi Children's Health and Medical Center Ōbu, | |
| Akron Children's Akron, Ohio | |
| Albany Medical Center Albany, New York | |
| Alberta Children's Calgary, | |
| All Children's Hospital St. Petersburg, Florida | |
| BC Children's Vancouver, British Columbia | |
| Boston Children's Boston, Massachusetts | |
| Cedars-Sinai Medical Center Los Angeles, California | |
| Children's Colorado Aurora, Colorado | |
| Children's Healthcare of Atlanta (CHOA) Atlanta, Georgia | |
| Children's Hospital of Philadelphia Philadelphia, Pennsylvania | Vinay Nadkarni, MD, MS - (nadkarni@chop.edu) |
| Children's Hospital of Richmond at VCU Richmond, Virginia | |
| Chldren's Hospital of Orange County Orange, California | |
| Cincinnati Children's Hospital Medical Center Cincinnati, Ohio | |
| Cohen Children's Medical Center Queens, New York | |
| Dartmouth Hitchcock Medical Center Lebanon, New Hampshire | |
| Dell Children's Medical Center Austin, Texas | |
| Erasmus MC - Sophia Children's Rotterdam, | |
| Great Ormond Street Hospital London, | |
| Gregorio Marañón General University Hospital Madrid, | |
| IRCCS Ospedale Pediatrico Bambino Gesu Rome, | |
| Instituto Roosevelt Bogotá, | |
| KK Women's & Children's Hospital Singapore, | |
| Kaiser Permanente Fresno, California | |
| Kentucky Children's Hospital Lexington, Kentucky | |
| King Chulalongkorn University Bangkok, | |
| Kobe Children's Hospital (Hyogo Prefectural) Kobe, | |
| Lurie Children's (Children's Hospital of Chicago) Chicago, Illinois | |
| Massachusetts General Hospital Boston, Massachusetts | |
| Medical City Children's Hospital Dallas, Texas | |
| Medical College of Wisconsin Milwaukee, Wisconsin | |
| Medical University of South Carolina Charleston, South Carolina | |
| Morgan Stanley Children's Hospital New York, New York | |
| Mount Sinai Kravis Children's Hospital New York, New York | |
| National Taiwan University Hospital Taipei, | |
| National University Hospital Singapore, | |
| Nationwide Children's Hospital Columbus, Ohio | |
| Nebraska Medical Center Omaha, Nebraska | |
| Nemours Children's Hospital Orlando, Florida | |
| Perth Children's Hospital Perth, Western Australia | |
| Queensland Children's Hospital South Brisbane, Queensland | |
| Rady Children's Hospital San Diego, California | |
| Riley Hospital for Children Indianapolis, Indiana | |
| Sabara Hospital Infantil São Paulo, | |
| Seattle Children's Hospital Seattle, Washington | |
| Seoul National University Bundang Hospital Seongnam, Kyeonggi-do | |
| St. Louis Children's Hospital St Louis, Missouri | |
| Stanford University Stanford, California | |
| Starship Children's Hospital Grafton, Auckland | |
| Stollery Children's Hospital Edmonton, Alberta | |
| Stony Brook University Hospital Stony Brook, New York | |
| The Children's Hospital at Westmead Westmead, New South Wales | |
| The Children's Hospital of San Antonio San Antonio, Texas | |
| The Johns Hopkins Hospital Baltimore, Maryland | |
| Tokyo Metropolitan Children's Medical Center Tokyo, | |
| University of Chicago, Comer Children's Hospital Chicago, Illinois | |
| University of Iowa Stead Family Children's Hospital Iowa City, Iowa | |
| University of North Carolina Chapel Hill, North Carolina | |
| University of Texas Southwestern Dallas, Texas | |
| Upstate Golisano Children's Hospital Syracuse, New York | |
| Valley Children's Hospital Madera, California |
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery (ASPIRE)
Kevin N Sheth, MD - kevin.sheth@yale.edu
NCT03907046
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Inclusion Criteria:
* Age at least 18 years
* Intracerebral hemorrhage (ICH) (including primary intraventricular hemorrhage) confirmed by brain CT or MRI
* Can be randomized within 14-180 days after ICH onset
* Non-valvular AF (defined as atrial fibrillation or atrial flutter), documented by electrocardiography or a physician-confirmed history of prior AF
* Provision of signed and dated informed consent form by patient or legally authorized representative
* For females of reproductive potential: use of highly effective contraception
Exclusion Criteria:
* Index event is hemorrhagic transformation of a brain infarction or hemorrhage into a tumor
* History of earlier ICH within 12 months preceding index event
* Active infective endocarditis
* Clear indication for anticoagulant drugs (e.g., requires anticoagulation for deep vein thrombosis or pulmonary embolism) or antiplatelet drugs (e.g., requires aspirin or clopidogrel for recent coronary stent).
* Previous or planned left atrial appendage closure
* Clinically significant bleeding diathesis
* Serum creatinine ≥2.5 mg/dL
* Active hepatitis or hepatic insufficiency with Child-Pugh score B or C
* Anemia (hemoglobin \<8 g/dL) or thrombocytopenia (\<100 x 10\^9/L) that is chronic in the judgment of the investigator
* Pregnant or breastfeeding
* Known allergy to aspirin or apixaban
* Concomitant participation in a competing trial
* Considered by the investigator to have a condition that precludes safe or active participation in the trial
* Persistent, uncontrolled systolic blood pressure (≥180 mm Hg)
* ICH caused by an arteriovenous malformation (AVM) that has not yet been secured DRUG: Apixaban, DRUG: Aspirin
Intracerebral Hemorrhage, Atrial Fibrillation
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Show 187 locations
Study Locations
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| Location | Contacts |
|---|---|
| Abbott Northwestern Hospital Minneapolis, Minnesota | |
| Albany Medical Center Albany, New York | |
| Arrowhead Regional Medical Center Colton, California | |
| Ascension Sacred Heart Pensacola Pensacola, Florida | |
| Ascension St. John Medical Center Tulsa, Oklahoma | |
| Augusta University Medical Center Augusta, Georgia | |
| Avera Research Institute Sioux Falls, South Dakota | |
| Banner University Medical Center Tucson, Arizona | |
| Baptist Health Lexington Lexington, Kentucky | |
| Barnes Jewish Hospital St Louis, Missouri | |
| Baylor College of Medicine Medical Center Houston, Texas | |
| Baystate Medical Center Springfield, Massachusetts | |
| Beth Israel Deaconess Medical Center Boston, Massachusetts | |
| Bon Secours St. Mary's Hospital Richmond, Virginia | |
| Boston Medical Center Boston, Massachusetts | |
| Broward Health Medical Center Fort Lauderdale, Florida | |
| Buffalo General Medical Center Buffalo, New York | |
| Burke Rehabilitation Center White Plains, New York | |
| Capital Health Regional Medical Center Pennington, New Jersey | |
| Carolinas Medical Center Charlotte, North Carolina | |
| Cedars-Sinai Medical Center Los Angeles, California | |
| Central DuPage Hospital Winfield, Illinois | |
| Chandler Regional Medical Center Chandler, Arizona | |
| Cleveland Clinic Cleveland, Ohio | |
| Cleveland Clinic Akron General Akron, Ohio | |
| Cleveland Clinic Tradition Hospital Port Saint Lucie, Florida | |
| Community Regional Medical Center of Fresno Fresno, California | |
| Cooperman Barnabas Medical Center West Orange, New Jersey | |
| Cox Medical Center South Springfield, Missouri | |
| Danbury Hospital Danbury, Connecticut | |
| Desert Regional Medical Center Palm Springs, California | |
| Doctors Medical Center Modesto, Modesto, CA Modesto, California | |
| Duke University Hospital Durham, North Carolina | |
| ECU Health Medical Center Greenville, North Carolina | |
| Eastern Maine Medical Center Bangor, Maine | |
| Eden Medical Center, Castro Valley Castro Valley, California | |
| Emory University Hospital Atlanta, Georgia | |
| Erlanger Health System Chattanooga, Tennessee | |
| Evanston Hospital Evanston, Illinois | |
| Forsyth Medical Center Winston-Salem, North Carolina | |
| Fort Sanders Regional Medical Center Knoxville, Tennessee | |
| Froedtert Hospital Milwaukee, Wisconsin | |
| Geisinger Medical Center Danville, Pennsylvania | |
| George Washington University Hospital Washington D.C., District of Columbia | |
| Good Samaritan Hospital Corvallis, Oregon | |
| Grady Memorial Hospital Delaware, Ohio | |
| Greenville Hospital System Greenville, South Carolina | |
| Hackensack University Medical Center Hackensack, New Jersey | |
| Harborview Medical Center Seattle, Washington | |
| Hartford Hospital Hartford, Connecticut | |
| HealthPartners Methodist Hospital Saint Louis Park, Minnesota | |
| Henry Ford Hospital Detroit, Michigan | |
| Hoag Hospital Newport Beach Newport Beach, California | |
| Hospital of the University of Pennsylvania Philadelphia, Pennsylvania | |
| Houston Methodist Hospital Houston, Texas | |
| Huntington Memorial Hospital Pasadena, California | |
| IU Health Methodist Hospital Indianapolis, Indiana | |
| Inova Fairfax Hospital Falls Church, Virginia | |
| J.W. Ruby Memorial Hospital Morgantown, West Virginia | |
| JFK Medical Center Edison, New Jersey | |
| Jackson Memorial Hospital Miami, Florida | |
| Javon Bea Hospital - Riverside Rockford, Illinois | |
| Jefferson Abington Hospital Abington, Pennsylvania | |
| Jersey Shore University Medical Center Neptune City, New Jersey | |
| Kaiser Permanente Fontana Medical Center Fontana, California | |
| Kaiser Permanente Los Angeles Medical Center Los Angeles, California | |
| Kaiser Permanente Redwood City Medical Center, Redwood City, CA Redwood City, California | |
| Kaiser Permanente Sacramento Medical Center Sacramento, California | |
| Kings County Hospital Center Brooklyn, New York | |
| Lahey Hospital & Medical Center Burlington, Massachusetts | |
| Lehigh Valley Hospital - Cedar Crest Allentown, Pennsylvania | |
| Long Beach Memorial Medical Center Long Beach, California | |
| Los Alamitos Medical Center Los Alamitos, California | |
| Loyola University Medical Center Maywood, Illinois | |
| M Health Fairview University of Minnesota Medical Center Minneapolis, Minnesota | |
| Maimonides Medical Center Brooklyn, New York | |
| Maine Medical Center Portland, Maine | |
| Massachusetts General Hospital Boston, Massachusetts | |
| Mayo Clinic Rochester, Minnesota | |
| McLaren Flint Flint, Michigan | |
| McLaren Macomb Mount Clemens, Michigan | |
| MedStar Georgetown University Hospital Washington D.C., District of Columbia | |
| Medical University of South Carolina University Hospital Charleston, South Carolina | |
| Medstar Washington Hospital Center Washington D.C., District of Columbia | |
| Memorial Hermann Texas Medical Center Houston, Texas | |
| Mercy Hospital Oklahoma City Oklahoma City, Oklahoma | |
| Mercy Hospital South St Louis, Missouri | |
| Mercy Hospital Springfield Springfield, Missouri | |
| Mercy Hospital St. Louis St Louis, Missouri | |
| Mercy San Juan Medical Center Carmichael, California | |
| Methodist University Hospital Memphis, Tennessee | |
| Metro Health Hospital Wyoming, Michigan | |
| MetroHealth Medical Center Cleveland, Ohio | |
| Montefiore Medical Center The Bronx, New York | |
| Morton Plant Hospital Clearwater, Florida | |
| Moses H. Cone Memorial Hospital Greensboro, North Carolina | |
| Mount Sinai West New York, New York | |
| Munson Medical Center Traverse City, Michigan | |
| NCH Hospital, Arlington Heights Arlington Heights, Illinois | |
| NYC Health + Hospitals/Elmhurst Elmhurst, New York | |
| NYP Columbia University Medical Center New York, New York | |
| NYP Weill Cornell Medical Center New York, New York | |
| NYU Langone Hospital - Brooklyn Brooklyn, New York | |
| New Hanover Regional Medical Center Wilmington, North Carolina | |
| New Hanover Regional Medical Center Wilmington, North Carolina | |
| NewYork-Presbyterian Brooklyn Methodist Hospital Brooklyn, New York | |
| North Shore University Hospital Manhasset, New York | |
| OSF St. Francis Medical Center Peoria, Illinois | |
| OSU Wexner Medical Center Columbus, Ohio | |
| OU Medical Center Oklahoma City, Oklahoma | |
| Ochsner Medical Center - Main Campus New Orleans, Louisiana | |
| Oregon Health & Science University Hospital Portland, Oregon | |
| Overlook Medical Center Summit, New Jersey | |
| PIH Health Hospital - Whittier Whittier, California | |
| PeaceHealth Sacred Heart Medical Center - RiverBend Springfield, Oregon | |
| Penn State Hershey Medical Center Hershey, Pennsylvania | |
| Presbyterian Medical Center Philadelphia, Pennsylvania | |
| Providence St. Vincent Medical Center Portland, Oregon | |
| Rancho Los Amigos National Rehabilitation Center Downey, California | |
| Regions Hospital Saint Paul, Minnesota | |
| Rhode Island Hospital Providence, Rhode Island | |
| Riverside Methodist Hospital Columbus, Ohio | |
| Ronald Reagan UCLA Medical Center Los Angeles, California | |
| Rush University Medical Center Chicago, Illinois | |
| SUNY Upstate Medical University Syracuse, New York | |
| Saint Alphonsus Regional Medical Center - Boise Boise, Idaho | |
| San Francisco General Hospital San Francisco, California | |
| Santa Barbara Cottage Hospital Santa Barbara, California | |
| Semmes Murphey Main Campus Memphis, Tennessee | |
| St. Cloud Hospital Saint Cloud, Minnesota | |
| St. David's Medical Center Austin, Texas | |
| St. John Medical Center Tulsa, Oklahoma | |
| St. John's Hospital Springfield, Illinois | |
| St. Joseph's Hospital Tampa, Florida | |
| St. Joseph's Hospital and Medical Center Phoenix, Arizona | |
| St. Jude Medical Center Fullerton, California | |
| St. Mary's Medical Center Grand Junction, Colorado | |
| Stanford University Medical Center Stanford, California | |
| Staten Island University Hospital - North Campus Staten Island, New York | |
| Stony Brook University Hospital Stony Brook, New York | |
| Strong Memorial Hospital Rochester, New York | |
| Swedish Medical Center - Cherry Hill Campus Seattle, Washington | |
| Tampa General Hospital Tampa, Florida | |
| Temple University Hospital Philadelphia, Pennsylvania | |
| The Mount Sinai Hospital New York, New York | |
| The Queen's Medical Center Honolulu, Hawaii | |
| The University of Vermont Medical Center Burlington, Vermont | |
| Thomas Jefferson University Hospital Philadelphia, Pennsylvania | |
| Trinity Health Saint Mary's Grand Rapids, Michigan | |
| Trinity Health Saint Mary's Grand Rapids, Michigan | |
| Tufts Medical Center Boston, Massachusetts | |
| UAMS Medical Center Little Rock, Arkansas | |
| UC Davis Medical Center Sacramento, California | |
| UC Irvine Medical Center Orange, California | |
| UF Health Jacksonville Jacksonville, Florida | |
| UH Cleveland Medical Center Cleveland, Ohio | |
| UMass Memorial Medical Center Worcester, Massachusetts | |
| UPMC Presbyterian Hospital Pittsburgh, Pennsylvania | |
| UT Southwestern Medical Center Dallas, Texas | |
| UVA Medical Center Charlottesville, Virginia | |
| United Hospital, St. Paul Saint Paul, Minnesota | |
| University of Alabama Hospital Birmingham, Alabama | |
| University of Chicago Medical Center Chicago, Illinois | |
| University of Cincinnati Medical Center Cincinnati, Ohio | |
| University of Colorado Hospital Aurora, Colorado | |
| University of Illinois Hospital Chicago, Illinois | |
| University of Iowa Medical Center Iowa City, Iowa | |
| University of Kansas Hospital Kansas City, Kansas | |
| University of Kentucky Hospital Lexington, Kentucky | |
| University of Louisville Hospital Louisville, Kentucky | |
| University of Michigan University Hospital Ann Arbor, Michigan | |
| University of Mississippi Medical Center Jackson, Mississippi | |
| University of Missouri Health Care Columbia, Missouri | |
| University of Nebraska Medical Center Omaha, Nebraska | |
| University of New Mexico Hospital Albuquerque, New Mexico | |
| University of North Carolina Medical Center Chapel Hill, North Carolina | |
| University of South Alabama University Hospital Mobile, Alabama | |
| University of Texas Health Science Center San Antonio San Antonio, Texas | |
| University of Utah Healthcare Salt Lake City, Utah | |
| VCU Medical Center Richmond, Virginia | |
| Vanderbilt University Hospital Nashville, Tennessee | |
| Vassar Brothers Medical Center Poughkeepsie, New York | |
| Virginia Mason Medical Center Seattle, Washington | |
| Wake Forest Baptist Medical Center Winston-Salem, North Carolina | |
| Wellstar Kennestone Hospital Marietta, Georgia | |
| Westchester Medical Center Valhalla, New York | |
| Yale New Haven Hospital New Haven, Connecticut |
EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation (EXCLAMATORY)
Pamela Grizzard - pamela.grizzard@vcuhealth.org
NCT06212791
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Inclusion Criteria:
* Age ≥18 years
* Diagnosis of paroxysmal AF
* Left ventricular ejection fraction ≥50%
* Scheduled for catheter ablation
* Able to speak, hear, and read English
* Willing and able to provide informed consent
Exclusion Criteria:
* Persistent or permanent AF
* Prior ablation (catheter based or surgical) for AF
* Significant sinus node dysfunction
* Implanted pacemaker or defibrillator
* Contraindication to or inability to complete cardiovascular magnetic resonance study
* Contraindication to or inability to complete exercise testing
* Chronic kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2
* Severe left ventricular hypertrophy
* Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to:
* Hypertrophic cardiomyopathy
* Cardiac amyloidosis
* Constrictive pericarditis
* Pulmonary arterial hypertension
* Prior cardiac surgery
* Active pregnancy BEHAVIORAL: Self- Report Evaluation-Duke Activity Status Index, BEHAVIORAL: Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire, DIAGNOSTIC_TEST: Cardiopulmonary exercise test (CPET), DIAGNOSTIC_TEST: Transthoracic echocardiogram, DIAGNOSTIC_TEST: Ambulatory cardiac rhythm assessment, DIAGNOSTIC_TEST: Cardiovascular magnetic resonance (CMR)
Paroxysmal Atrial Fibrillation
Catheter ablation, Exercise capacity
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| Location | Contacts |
|---|---|
| Virginia Commonwealth University Richmond, Virginia | Pamela Grizzard - (pamela.grizzard@vcuhealth.org) Melissa Sears - (melissa.sears@vcuhealth.org) |
A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF) (OMNY-AF)
Study Contact - rshar120@its.jnj.com
NCT06455098
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Inclusion Criteria:
* Diagnosed with symptomatic paroxysmal AF with:
• At least two symptomatic AF episodes within last six months from enrollment
• At least one electrocardiographically documented AF episode within twelve months prior to enrollment * Failed at least one Class I or Class III antiarrhythmic drug * Willing and capable to provide consent * Able and willing to comply with all pre-, post- and follow-up testing and requirements
Exclusion Criteria:
* Previously diagnosed with persistent AF (greater than \[\>\] 7 days in duration)
* AF secondary to electrolyte imbalance, thyroid disease, or reversible or non-cardiac cause.
* Previous surgical or catheter ablation for AF
* Patients known to require ablation outside the PV ostia and outside the CTI region.
* Documented severe dilatation of the left atrium (LAD\>50 mm) antero-posterior diameter on imaging within 6 months prior to enrollment
* Documented left atrium (LA) thrombus by imaging within 48 hours of the procedure
* Documented severely compromised left ventricular ejection fraction (LVEF \<40%) by imaging within 6 months prior to enrollment
* Uncontrolled heart failure or New York Heart Association (NYHA) Class III or IV
* History of blood clotting, bleeding abnormalities or contraindication to anticoagulation (heparin, warfarin, or dabigatran)
* Documented thromboembolic event (including transient ischemic attack or TIA) within the past 6 months
* Previous Percutaneous Coronary Intervention (PCI)/ myocardial infarction \[MI\] within the past 2 months
* Coronary Artery Bypass Grafting (CABG) surgery within the past 6 months
* Valvular cardiac surgical/percutaneous procedure
* Unstable angina within 6 months
* Anticipated cardiac transplantation, cardiac surgery, or other major surgery within the next 12 months
* Significant pulmonary disease or any other disease or malfunction of the lungs or respiratory system that produces severe chronic symptoms
* Significant congenital anomaly or medical problem that in the opinion of the investigator would preclude enrollment in this study
* Prior diagnosis of pulmonary vein stenosis
* Pre-existing hemi diaphragmatic paralysis
* Acute illness, active systemic infection, or sepsis
* Presence of intracardiac thrombus, myxoma, tumor, interatrial baffle or patch or other abnormality that precludes catheter introduction or manipulation
* Severe mitral regurgitation
* Presence of an implanted pacemaker or Implantable Cardioverter-Defibrillator (ICD) or other implanted metal cardiac device (other than coronary stents) that may interfere with the PF energy field)
* Presence of a condition that precludes vascular access
* Current enrollment in an investigational study evaluating another device or drug
* Women who are pregnant (as evidenced by pregnancy test if pre-menopausal), lactating, or who are of child-bearing age and plan on becoming pregnant during the course of the clinical investigation
* Life expectancy less than 12 months
* Presenting contra-indications for the devices used in the study, as indicated in the respective Instructions for Use (IFU) DEVICE: OMNYPULSE™ Catheter with the TRUPULSE Generator
Atrial Fibrillation
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Show 46 locations
Study Locations
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| Location | Contacts |
|---|---|
| Advent Health Orlando Orlando, Florida | |
| Ascension St. Vincent's Jacksonville, Florida | |
| Baptist Health Research Institute Jacksonville, Florida | |
| Beaumont Health Systems Royal Oak, Michigan | |
| Brigham and Women's Hospital Boston, Massachusetts | |
| California Pacific Medical Center- Sutter Health San Francisco, California | |
| Canberra Heart Rhythm Garran, | |
| Cardiovascular Associates of Marin Larkspur, California | |
| Cleveland Clinic Cleveland, Ohio | |
| Emory Saint Joseph's Hospital Atlanta, Georgia | |
| HCA Florida Mercy Hospital Miami, Florida | |
| Hartford Hospital Hartford, Connecticut | |
| Hoag Memorial Hospital Newport Beach, California | |
| Inova Fairfax Medical Campus- Inova Heart and Vascular Institute Falls Church, Virginia | |
| Intermountain Medical Center Murray, Utah | |
| Johns Hopkins Baltimore, Maryland | |
| Lenox Hill Hospital New York, New York | |
| Loma Linda Medical Center Loma Linda, California | |
| Massachusetts General Boston, Massachusetts | |
| Memorial Health University Medical Center Savannah, Georgia | |
| Mills Peninsula Health Services Burlingame, California | |
| Minneapolis Heart Institute Minneapolis, Minnesota | |
| Montefiore Medical Center The Bronx, New York | |
| Morristown Medical Center Morristown, New Jersey | |
| Mount Sinai School of Medicine New York, New York | |
| NCH Healthcare Naples, Florida | |
| New Mexico Heart Institute Albuquerque, New Mexico | |
| New York Presbyterian - Weill Cornell Medical Ctr New York, New York | |
| NorthShore University Medical Center Glenview, Illinois | |
| Northside Hospital Atlanta, Georgia | |
| Phoenix Cardiovascular Research Group Phoenix, Arizona | |
| Piedmont Healthcare Atlanta, Georgia | |
| Providence Saint John s Health Center Santa Monica, California | |
| Royal Adelaide Hospital Adelaide, South Australia | |
| Royal Melbourne Hospital Parkville, Victoria | |
| San Diego Cardiac Center San Diego, California | |
| Scripps Clinic/Prebys Cardiovascular Institute La Jolla, California | |
| Sentara Norfolk General Hospital Norfolk, Virginia | |
| St Francis Hospital Roslyn, New York | |
| Texas Cardiac Arrhythmia Research Foundation Austin, Texas | |
| Texas Heart Institute Houston, Texas | |
| University of Colorado Denver, Colorado | |
| University of Pennsylvania Health System Philadelphia, Pennsylvania | |
| Virginia Commonwealth University Richmond, Virginia | |
| WakeMed Heart & Vascular Raleigh, North Carolina | |
| York Hospital York Village, Maine |
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure (DRAIN-HF)
Rubi Reyes-Fuentez - rubi@procyrion.com
NCT05677100
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Inclusion Criteria (Randomized Study):
* Currently admitted to the hospital with a primary diagnosis of decompensated heart failure, irrespective of ejection fraction (EF);
* Patients should be on maximally tolerated diuretic therapy and not diuresing sufficiently before being enrolled in DRAIN-HF. After being up-titrated on diuretics, patients should be followed for at least 24 hours on the higher of: i) furosemide 80 mg IV bid or equivalent or ii) IV furosemide or equivalent IV loop diuretic at a dose 2.5 x total daily home dose of furosemide equivalents in 2 divided doses, as tolerated, patient must have: Urine Output \<1,500mL in a 12-hour period OR a Net Fluid Loss ≤375mL in a 12-hour period.
* Persistent signs and/or symptoms of congestion as evidenced by at least 2+ pitting edema, elevated jugular venous pressure \>12 cm water or ascites after treatment with IV diuretics per inclusion criterion 2.;
* Age \>21 years and able to provide written informed consent;
* Negative pregnancy test if patient is of child-bearing potential.
Exclusion Criteria (Randomized Study):
* Treatment with high dose IV inotropes within the last 48 hours prior to enrollment. High dose is defined as \>5 µg/kg/min dopamine OR \>5 µg/kg/min dobutamine OR \>0.375 µg/kg/min milrinone;
* Active and ongoing hypotension with a systolic blood pressure \<90 mmHg lasting more than 30 minutes or a mean arterial pressure (MAP) \<60 mmHg lasting more than 30 minutes at enrollment;
* Treatment with vasopressors (defined as phenylephrine, norepinephrine, epinephrine or, vasopressin) within 48 hours prior to enrollment;
* An estimated PASP of \>80 mmHg as measured on echocardiogram or echocardiographic evidence of primarily right heart failure;
* Acute kidney failure defined as an increase in serum creatinine to ≥4.0mg/dL (≥353.6 µmol/L) at enrollment;
* Evidence of contrast induced nephropathy, nephritis or nephrotic syndrome;
* Prior kidney transplant, single kidney, partial nephrectomy OR use of dialysis, continuous renal replacement therapy (CRRT) or ultrafiltration in the last 90 days prior to enrollment;
* Confirmed decompensated cirrhosis (defined as Child Pugh class B or C) or concern for shock liver (AST \> 1000U/L or total Bilirubin \> 5.0mg/dl) at enrollment;
* Presence of an active, uncontrolled infection that would preclude safe placement or removal of the device;
* Prior heart transplant or likely heart transplantation before the 30- day follow-up visit;
* Current or previous support with a durable LVAD at any time or planned LVAD insertion before the 30-day follow-up visit;
* Use of an intra-aortic balloon pump (IABP), extracorporeal membrane oxygenation (ECMO), or percutaneous ventricular assist devices (e.g. Impella or TandemHeart) within the last 30 days;
* Confirmed diagnosis of AL amyloidosis;
* Acute myocardial infarction Type 1 within 30 days of enrollment, or planned coronary revascularization in the next 30 days;
* Stroke within 30 days of enrollment;
* Severe Bleeding Risk (any of the following):
• Previous intracranial bleed unless there is documentation in the medical record (from a physician that is not part of the study) that the patient can safely use anticoagulation for 7 days,
• GI bleeding within 6 months requiring hospitalization and/or transfusion,
• Recent major surgery within 30 days if the surgical wound is judged to be associated with an increased risk of bleeding,
• Procedure with arterial ilio-femoral access \> 6 FR within 30 days,
• Platelet count \<75,000 cells/mm3,
• Uncorrectable bleeding diathesis or coagulopathy (e.g. INR ≥2 not due to anticoagulation therapy) or hypercoaguable state including HIT;
• Inability to tolerate anticoagulation therapy for up to 7 days. * Contraindicated Anatomy :
• Descending aortic anatomy that would prevent safe placement of the device \[\<18 mm or \>31 mm aorta diameter at deployment location (measured between the superior aspect of the T10 vertebra and superior aspect of the L1 vertebra)\],
• Ilio-femoral diameter or peripheral vascular anatomy that would preclude safe placement of a 21F (outer diameter) introducer sheath,
• Femoral artery depth inconsistent with use of closure device,
• Abnormalities or severe vascular disease that would preclude safe access and device delivery (e.g. aneurysm with thrombus, marked tortuosity, significant narrowing or inadequate size of the abdominal aorta, iliac or femoral arteries, or severe calcification),
• Known connective tissue disorder (e.g. Marfan Syndrome) or other aortopathy at risk of vascular injury,
• Any endovascular stent graft in the descending aorta. Any endovascular stent graft in the femoro-iliac vessels that is not well endothelialized and would preclude safe introduction/removal of the Aortix pump as demonstrated by imaging. * Known hypersensitivity or contraindication to study or procedure medications (e.g. anticoagulation therapy) or device materials (e.g. history of severe reaction to nickel or nitinol); * Participation in any other clinical investigation that is likely to confound study results or affect the study; * Poor health such that the patient is unable to undergo the Aortix device placement/retrieval and/or unlikely to be able to survive to the 30-day visit; * Unable or unwilling to undergo screening (imaging, PA Catheter placement), device implant and retrieval procedures or return for 30-day visit. Inclusion Criteria (Advanced Heart Failure Registry): * Currently admitted to the hospital with a primary diagnosis of decompensated HF, irrespective of ejection fraction (EF). * Patient has already been evaluated and indicated to receive an LVAD or heart transplant and will receive the LVAD or be listed for heart transplantation in the next 30 days if their congestion status and renal function improves. * Patient must have been treated with ≥ 80 mg IV furosemide bid or equivalent and have evidence of increasing diuretic dosing requirements over the past 12 months, as tolerated. * Must have evidence of refractoriness to medical management as documented by persistent signs and/or symptoms of congestion as evidenced by at least 2+ pitting edema, elevated jugular venous pressure \>12 cm water, or ascites after treatment with IV diuretics for a minimum of 24 hours. * Serum creatinine ≥ 2.0 mg/dL AND eGFR ≤ 45 ml/min/1.73m2 at time of enrollment * Age ≥ 21 years and able to provide written informed consent. * Negative pregnancy test if patient is of childbearing potential. Exclusion Criteria (Advanced Heart Failure Registry): * Treatment with high dose IV inotropes within 48 hours prior to enrollment. High dose is defined as any one of the following: \>5 µg/kg/min dopamine OR \>5 µg/kg/min dobutamine OR \>0.375 µg/kg/min milrinone. * Active and ongoing hypotension with a systolic blood pressure \<80 mmHg lasting more than 30 minutes or a mean arterial pressure (MAP) \<55 mmHg lasting more than 30 minutes at enrollment. * Treatment with vasopressors (defined as phenylephrine, norepinephrine, epinephrine or, vasopressin) within 48 hours prior to enrollment. * An estimated PASP of \>80 mmHg as measured on echocardiogram or echocardiographic evidence of primarily right heart failure. * Acute kidney failure defined as an increase in serum creatinine to ≥ 4.0mg/dL at enrollment. * Evidence of contrast-induced nephropathy, nephritis, or nephrotic syndrome. * Prior kidney transplant, single kidney, partial nephrectomy OR use of dialysis, continuous renal replacement therapy (CRRT), or ultrafiltration in the last 90 days prior to enrollment. * Confirmed decompensated cirrhosis (defined as Child Pugh class B or C) or concern for shock liver (AST \> 1000U/L or total Bilirubin \> 5.0mg/dl) at enrollment. * Presence of an active, uncontrolled infection that would preclude safe placement or removal of the device. * Current or previous support with a durable LVAD. * INTERMACS Profile 1 at enrollment. * Currently on mechanical ventilatory support. * Use of an extracorporeal membrane oxygenation (ECMO) or percutaneous ventricular assist device (e.g., Impella or TandemHeart) within the last 30 days. * Confirmed diagnosis of AL amyloidosis. * Acute myocardial infarction Type 1 within 30 days of enrollment or planned coronary revascularization in the next 30 days. * Stroke within 30 days of enrollment. * Severe Bleeding Risk (any of the following): * Previous intracranial bleed unless there is documentation in the medical record (from a physician that is not part of the study) that the patient can safely use anticoagulation for 7 days. * GI bleeding within 6 months requiring hospitalization and/or transfusion. * Recent major surgery within 30 days if the surgical wound is judged to be associated with an increased risk of bleeding. * Procedure with arterial ilio-femoral access \> 6 Fr within 30 days. * Platelet count \<75,000 cells/mm3 . * Uncorrectable bleeding diathesis or coagulopathy (e.g., INR≥ 2 not due to anticoagulation therapy) or hypercoagulable state including HIT. * Inability to tolerate anticoagulation therapy for up to 7 days. * Contraindicated Anatomy : * Descending aortic anatomy that would prevent safe placement of the device \[\<18 mm or \>31 mm aorta diameter at deployment location (measured between the superior aspect of the T10 vertebra and superior aspect of the L1 vertebra)\]. * Ilio-femoral diameter or peripheral vascular anatomy that would preclude safe placement of a 21 Fr (outer diameter) introducer sheath. * Femoral artery depth inconsistent with use of closure device. * Abnormalities or severe vascular disease that would preclude safe access and device delivery (e.g., aneurysm with thrombus; marked tortuosity; significant narrowing or inadequate size of the abdominal aorta, iliac, or femoral arteries; or severe calcification). * Known connective tissue disorder (e.g., Marfan Syndrome) or other aortopathy at risk of vascular injury. * Any endovascular stent graft in the descending aorta. Any endovascular stent graft in the femoro-iliac vessels that is not well endothelialized and would preclude safe introduction/removal of the Aortix pump as demonstrated by imaging. * Known hypersensitivity or contraindication to study or procedure medications (e.g., anticoagulation therapy) or device materials (e.g., history of severe reaction to nickel or nitinol). * Participation in any other clinical investigation that is likely to confound study results or affect the study. * Poor health such that the patient is unable to undergo the Aortix device placement/retrieval and/or unlikely to be able to survive to the 30-day visit. * Unable or unwilling to undergo screening, device implant and retrieval procedures, or return for 30-day visit.
• Previous intracranial bleed unless there is documentation in the medical record (from a physician that is not part of the study) that the patient can safely use anticoagulation for 7 days,
• GI bleeding within 6 months requiring hospitalization and/or transfusion,
• Recent major surgery within 30 days if the surgical wound is judged to be associated with an increased risk of bleeding,
• Procedure with arterial ilio-femoral access \> 6 FR within 30 days,
• Platelet count \<75,000 cells/mm3,
• Uncorrectable bleeding diathesis or coagulopathy (e.g. INR ≥2 not due to anticoagulation therapy) or hypercoaguable state including HIT;
• Inability to tolerate anticoagulation therapy for up to 7 days. * Contraindicated Anatomy :
• Descending aortic anatomy that would prevent safe placement of the device \[\<18 mm or \>31 mm aorta diameter at deployment location (measured between the superior aspect of the T10 vertebra and superior aspect of the L1 vertebra)\],
• Ilio-femoral diameter or peripheral vascular anatomy that would preclude safe placement of a 21F (outer diameter) introducer sheath,
• Femoral artery depth inconsistent with use of closure device,
• Abnormalities or severe vascular disease that would preclude safe access and device delivery (e.g. aneurysm with thrombus, marked tortuosity, significant narrowing or inadequate size of the abdominal aorta, iliac or femoral arteries, or severe calcification),
• Known connective tissue disorder (e.g. Marfan Syndrome) or other aortopathy at risk of vascular injury,
• Any endovascular stent graft in the descending aorta. Any endovascular stent graft in the femoro-iliac vessels that is not well endothelialized and would preclude safe introduction/removal of the Aortix pump as demonstrated by imaging. * Known hypersensitivity or contraindication to study or procedure medications (e.g. anticoagulation therapy) or device materials (e.g. history of severe reaction to nickel or nitinol); * Participation in any other clinical investigation that is likely to confound study results or affect the study; * Poor health such that the patient is unable to undergo the Aortix device placement/retrieval and/or unlikely to be able to survive to the 30-day visit; * Unable or unwilling to undergo screening (imaging, PA Catheter placement), device implant and retrieval procedures or return for 30-day visit. Inclusion Criteria (Advanced Heart Failure Registry): * Currently admitted to the hospital with a primary diagnosis of decompensated HF, irrespective of ejection fraction (EF). * Patient has already been evaluated and indicated to receive an LVAD or heart transplant and will receive the LVAD or be listed for heart transplantation in the next 30 days if their congestion status and renal function improves. * Patient must have been treated with ≥ 80 mg IV furosemide bid or equivalent and have evidence of increasing diuretic dosing requirements over the past 12 months, as tolerated. * Must have evidence of refractoriness to medical management as documented by persistent signs and/or symptoms of congestion as evidenced by at least 2+ pitting edema, elevated jugular venous pressure \>12 cm water, or ascites after treatment with IV diuretics for a minimum of 24 hours. * Serum creatinine ≥ 2.0 mg/dL AND eGFR ≤ 45 ml/min/1.73m2 at time of enrollment * Age ≥ 21 years and able to provide written informed consent. * Negative pregnancy test if patient is of childbearing potential. Exclusion Criteria (Advanced Heart Failure Registry): * Treatment with high dose IV inotropes within 48 hours prior to enrollment. High dose is defined as any one of the following: \>5 µg/kg/min dopamine OR \>5 µg/kg/min dobutamine OR \>0.375 µg/kg/min milrinone. * Active and ongoing hypotension with a systolic blood pressure \<80 mmHg lasting more than 30 minutes or a mean arterial pressure (MAP) \<55 mmHg lasting more than 30 minutes at enrollment. * Treatment with vasopressors (defined as phenylephrine, norepinephrine, epinephrine or, vasopressin) within 48 hours prior to enrollment. * An estimated PASP of \>80 mmHg as measured on echocardiogram or echocardiographic evidence of primarily right heart failure. * Acute kidney failure defined as an increase in serum creatinine to ≥ 4.0mg/dL at enrollment. * Evidence of contrast-induced nephropathy, nephritis, or nephrotic syndrome. * Prior kidney transplant, single kidney, partial nephrectomy OR use of dialysis, continuous renal replacement therapy (CRRT), or ultrafiltration in the last 90 days prior to enrollment. * Confirmed decompensated cirrhosis (defined as Child Pugh class B or C) or concern for shock liver (AST \> 1000U/L or total Bilirubin \> 5.0mg/dl) at enrollment. * Presence of an active, uncontrolled infection that would preclude safe placement or removal of the device. * Current or previous support with a durable LVAD. * INTERMACS Profile 1 at enrollment. * Currently on mechanical ventilatory support. * Use of an extracorporeal membrane oxygenation (ECMO) or percutaneous ventricular assist device (e.g., Impella or TandemHeart) within the last 30 days. * Confirmed diagnosis of AL amyloidosis. * Acute myocardial infarction Type 1 within 30 days of enrollment or planned coronary revascularization in the next 30 days. * Stroke within 30 days of enrollment. * Severe Bleeding Risk (any of the following): * Previous intracranial bleed unless there is documentation in the medical record (from a physician that is not part of the study) that the patient can safely use anticoagulation for 7 days. * GI bleeding within 6 months requiring hospitalization and/or transfusion. * Recent major surgery within 30 days if the surgical wound is judged to be associated with an increased risk of bleeding. * Procedure with arterial ilio-femoral access \> 6 Fr within 30 days. * Platelet count \<75,000 cells/mm3 . * Uncorrectable bleeding diathesis or coagulopathy (e.g., INR≥ 2 not due to anticoagulation therapy) or hypercoagulable state including HIT. * Inability to tolerate anticoagulation therapy for up to 7 days. * Contraindicated Anatomy : * Descending aortic anatomy that would prevent safe placement of the device \[\<18 mm or \>31 mm aorta diameter at deployment location (measured between the superior aspect of the T10 vertebra and superior aspect of the L1 vertebra)\]. * Ilio-femoral diameter or peripheral vascular anatomy that would preclude safe placement of a 21 Fr (outer diameter) introducer sheath. * Femoral artery depth inconsistent with use of closure device. * Abnormalities or severe vascular disease that would preclude safe access and device delivery (e.g., aneurysm with thrombus; marked tortuosity; significant narrowing or inadequate size of the abdominal aorta, iliac, or femoral arteries; or severe calcification). * Known connective tissue disorder (e.g., Marfan Syndrome) or other aortopathy at risk of vascular injury. * Any endovascular stent graft in the descending aorta. Any endovascular stent graft in the femoro-iliac vessels that is not well endothelialized and would preclude safe introduction/removal of the Aortix pump as demonstrated by imaging. * Known hypersensitivity or contraindication to study or procedure medications (e.g., anticoagulation therapy) or device materials (e.g., history of severe reaction to nickel or nitinol). * Participation in any other clinical investigation that is likely to confound study results or affect the study. * Poor health such that the patient is unable to undergo the Aortix device placement/retrieval and/or unlikely to be able to survive to the 30-day visit. * Unable or unwilling to undergo screening, device implant and retrieval procedures, or return for 30-day visit.
DEVICE: Aortix System
Heart Failure, Cardiorenal Syndrome, Cardio-Renal Syndrome, ADHF, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Failure, With Decompensation, Heart Failure, Congestive
mechanical circulatory support, percutaneous
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Show 49 locations
Study Locations
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| Location | Contacts |
|---|---|
| AdventHealth Tampa Tampa, Florida | |
| Advocate Aurora - Good Samaritan Downers Grove, Illinois | |
| Advocate IMMC Chicago, Illinois | |
| AnMed Health Anderson, South Carolina | |
| Ascenscion Alexian Brothers Elk Grove Village, Illinois | |
| Ascension Sacred Heart Pensacola, Florida | |
| Ascension via Christi Kansas Wichita, Kansas | |
| Atrium Health Sanger Heart and Vascular Institute Charlotte, North Carolina | |
| Banner--University Medical Center Phoenix Phoenix, Arizona | |
| BayCare Medical/St. Joseph's Hospital Tampa, Florida | |
| Baylor Scott & White Plano, Texas | |
| Baylor Scott & White Plano, Texas | |
| Cleveland Clinic Florida Weston, Florida | |
| Duke University Medical Center Durham, North Carolina | |
| Emory University Hospital Atlanta, Georgia | |
| Hackensack University Medical Center Hackensack, New Jersey | |
| Henry Ford Detroit, Michigan | |
| HonorHealth Medical Center Scottsdale, Arizona | |
| Intermountain Health St. George, Utah | |
| Jefferson Abington Hospital Abington, Pennsylvania | |
| Jersey Shore University Medical Center Neptune City, New Jersey | |
| John Muir Health Walnut Creek, California | |
| Mayo Clinic - Arizona Phoenix, Arizona | Erica Boyd - (boyd.erica@mayo.edu) |
| Mount Sinai Morningside New York, New York | |
| New York Presbyterian - Brooklyn Methodist Hospital Brooklyn, New York | Jhane Phanor - (jhp4004@nyp.org) |
| Northwell Health (Lenox Hill) New York, New York | |
| Northwell Health (Staten Island) Staten Island, New York | |
| Novant Health New Hanover Regional Medical Center Wilmington, North Carolina | |
| Nuvance Health Poughkeepsie, New York | |
| Nyph/Cumc New York, New York | |
| Oklahoma Cardiovascular Research Group Oklahoma City, Oklahoma | |
| Oregon Health & Sciences University Portland, Oregon | |
| Penn Presbyterian Medical Center Philadelphia, Pennsylvania | |
| Piedmont Healthcare INC. Augusta, Georgia | |
| San Francisco Veterans Administration San Francisco, California | |
| Semmelweis University Budapest, | Laura Kosa-Hobor - (hobor.laura@semmelweis.hu) |
| Tallahassee Research Institute Tallahassee, Florida | |
| Texas Heart Institute Houston, Texas | |
| The Ohio State University Columbus, Ohio | |
| Thomas Jefferson University Hospital Philadelphia, Pennsylvania | |
| University of California San Francisco San Francisco, California | |
| University of Chicago Chicago, Illinois | |
| University of Michigan, Cardiovascular Medicine Ann Arbor, Michigan | |
| University of Mississippi Medical Center Jackson, Mississippi | |
| University of South Florida Tampa, Florida | |
| University of Virginia Charlottesville, Virginia | |
| Virginia Commonwealth University Richmond, Virginia | |
| Wellstar Research Institue Marietta, Georgia | |
| Zuckerberg San Francisco General San Francisco, California |
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation (ATHENA)
Novo Nordisk - clinicaltrials@novonordisk.com
NCT06200207
Show full eligibility criteria
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Inclusion Criteria:
* Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 milligrams per liter (mg/L) at screening (visit 1)
* Disease specific - cardiovascular:
* N-terminal-pro-brain natriuretic peptide (NT-proBNP) greater than or equal to 225 picograms per milliliter (pg/mL) (375 pg/mL for participants with atrial fibrillation/flutter) at screening
* Diagnosis of heart failure (New York heart association (NYHA) Class II-III)
* Left ventricular ejection fraction (LVEF) greater than 40 percent documented by echocardiography within 12 months prior to or at screening (visit 1). The LVEF must be documented in medical records and the most recent measurement must be used to determine eligibility with no interim event signalling potential deterioration in ejection fraction (example myocardial infarction (MI) or heart failure (HF) hospitalisation)
* Structural heart disease and/or functional heart disease documented by echocardiography within 12 months prior to or at screening (visit 1) showing at least one of the following:
• Left atrial (LA) volume index greater than 34 milliliter per square meter (mL/m\^2)
• LA diameter greater than or equal to 3.8 centimeter (cm)
• LA length greater than or equal to 5.0 cm
• LA area greater than or equal to 20 square centimeter (cm\^2)
• LA volume greater than or equal to 55 milliliter (mL)
• Intraventricular septal thickness greater than or equal to 1.1 cm
• Posterior wall thickness greater than or equal to 1.1 cm
• LV mass index greater than or equal to 115 gram per square meter (g/m\^2) in men or greater than or equal to 95 g/m\^2 in women h) E/e' (mean septal and lateral) greater than or equal to 10 i) e' (mean septal and lateral) less than 9 centimeter per second (cm/s) * No heart failure hospitalisations or urgent heart failure visits between screening and randomisation * Able to perform the 6-minute walk test (6MWT) at screening with a minimum distance of 100 metres * Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score lesser than 80 at screening
Exclusion Criteria:
* Medical conditions - cardiovascular:
* Myocardial infarction, stroke, unstable angina pectoris, transient ischaemic attack, or heart failure hospitalisation within 30 days prior to screening (visit 1)
* Systolic blood pressure greater than or equal to 180 millimeters of mercury (mmHg) at screening (visit 1). If the systolic blood pressure is 160-179 mmHg, the patient should be receiving greater than or equal to 3 antihypertensive drugs
* Heart rate above 110 or below 40 beats per minute as evaluated on the Electrocardiogram (ECG) performed at screening (visit 1)
* Planned coronary, carotid or peripheral artery revascularisation known during the screening period (visit 1)
* Planned cardiac device or atrial flutter/atrial fibrillation ablation procedure known during the screening period (visit 1)
* Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2)
* Heart failure due to infiltrative cardiomyopathy (e.g., sarcoid, amyloid), arrhythmogenic right ventricular cardiomyopathy, Takutsubo cardiomyopathy, genetic hypertrophic cardiomyopathy or obstructive cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, uncorrected more than moderate primary valve disease
* Primary pulmonary hypertension, chronic pulmonary embolism, severe pulmonary disease including chronic obstructive pulmonary disease (COPD)
* Any other condition judged by the investigator that could account for heart failure symptoms and signs (e.g., anaemia, hypothyroidism)
* Medical conditions - infections/immunosuppression:
* Clinical evidence of, or suspicion of, active infection at the discretion of the investigator DRUG: Ziltivekimab, DRUG: Placebo
Heart Failure, Systemic Inflammation
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Show 240 locations
Study Locations
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| Location | Contacts |
|---|---|
| "AHEPA" University General Hospital of Thessaloniki Thessaloniki, | |
| "Hygeia" General Hospital of Athens Athens, | |
| "Laiko" General Hospital of Athens Athens, | |
| 'G. Gennimatas' General Hospital of Athens Athens, | |
| 'G. Gennimatas' General Hospital of Athens - Cardiology Department Athens, | |
| 'Ippokrateio' General Hospital of Thessaloniki Thessaloniki, | |
| 10 Wojskowy Szpital Kliniczny z Poliklinika - Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Bydgoszczy Bydgoszcz, | |
| 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu Wroclaw, | |
| AMS Cardiology Horsham, Pennsylvania | |
| Adana Şehir Eğitim ve Araştırma Hastanesi Adana, | |
| Advanced Cardiovascular, LLC Alexander City, Alabama | |
| Advara HeartCare Mulgrave Mulgrave, Victoria | |
| Advara Heartcare Joondalup, Western Australia | |
| Afyonkarahisar Health Sciences University Afyonkarahisar, | |
| Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji Afyonkarahisar, | |
| Alexandra General Hospital, Therapeutic Clinic Athens, | |
| All India Institute of Medical Sciences (AIIMS) New Delhi, | |
| All India Institute of Medical Sciences (AIIMS), Bhubaneswar Bhubaneswar, Odisha | |
| All India Institute of Medical Sciences (AIIMS), Bhubaneswar Bhubaneswar, Odisha | |
| All India Institute of Medical Sciences (AIIMS), Nagpur Nagpur, Maharashtra | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| Ankara Bilkent Şehir Hastanesi-Kardiyoloji Ankara, | |
| Ankara Sehir Hastanesi Cardiology Ankara, | |
| B M Birla Heart Research Centre Kolkata, West Bengal | |
| B M Birla Heart Research Centre Kolkata, West Bengal | |
| Ballarat Base Hospital Ballarat, Victoria | |
| Ballarat Base Hospital Ballarat, Victoria | |
| Basaksehir Cam ve Sakura Sehir Hastanesi Istanbul, | |
| Bursa Şehir Hastanesi- Kardiyoloji Bursa, | |
| CHLO, EPE - Hospital São Francisco Xavier Lisbon, | |
| CHTâmega e Sousa - Hospital Padre Américo Guilhufe - Penafiel, | |
| CHU de Quebec-Uni Laval-Hotel Québec, | |
| CIPREC Arenales CABA, | |
| CIPREC Pueyrredon Buenos Aires, | |
| CPS Research Waterloo, Ontario | |
| CPS Research Waterloo, Ontario | |
| Cambridge Cardiac Care Centre Cambridge, Ontario | |
| Canberra Hospital Garran, | |
| Cardio and Vascular Assoc-CAVA Bloomfield Hills, Michigan | |
| Cardiology & Medicine Clinic Little Rock, Arkansas | |
| Cardiología Palermo City of Buenos Aires, Buenos Aires | |
| Cardiomedicum Sp. z o.o. Krakow, Lesser Poland Voivodeship | |
| Cardiomedicum Sp. z o.o. Krakow, Lesser Poland Voivodeship | |
| Centre Hospitalier Intercommunal Toulon La Seine-Sur-Mer - Hopital Sainte Musse Toulon, | |
| Centre Hospitalier Regional Universitaire de Tours-Hopital Trousseau Chambray-lès-Tours, | |
| Centre Hospitalier Universitaire de Poitiers Poitiers, | |
| Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou Rennes, | |
| Centre Hospitalier Universitaire de Rouen-Hopital Charles Nicolle Rouen, | |
| Centro Cardiovascular Salta Salta, | |
| Centro Hospitalar Lisboa Norte Lisbon, | |
| Centro Hospitalar de Setubal Setúbal, | |
| Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli Buenos Aires, | |
| Centro Médico CIMEL Lanús Este, Buenos Aires | |
| Centrum Medyczne Intercor Sp. z o.o. Bydgoszcz, Kuyavian-Pomeranian Voivodeship | |
| Chicago Medical Research LLC Hazel Crest, Illinois | |
| Chopda Medicare and Research Centre Pvt. Ltd. Nashik, Maharashtra | |
| Chopda Medicare and Research Centre Pvt. Ltd. Nashik, Maharashtra | |
| Chru de Nancy - Hopital Brabois Vandœuvre-lès-Nancy, | |
| Clearwater Cardiovascular Consultants Safety Harbor, Florida | |
| Clearwater Cardiovascular Consultants Safety Harbor, Florida | |
| Clinical Advancement Center San Antonio, Texas | |
| Clinical Advancement Ctr, PLLC San Antonio, Texas | |
| Clinical Research Solutions Inc. Waterloo, Ontario | |
| Clínica Nuevas Tecnologías en Diabetes y Endocrinología Seville, | |
| Complejo Hospitalario Universitario de Santiago Santiago de Compostela, | |
| Consultorio Integral de Atención al Diabético Morón, | |
| Corcare Cardiovascular Research Scarborough Village, Ontario | |
| David Turbay, MD, PLLC El Paso, Texas | |
| Diabetes Heart Research Centre Toronto, Ontario | |
| Diabetes Heart Research Centre Toronto, Ontario | |
| Dr. Ram Manohar Lohia Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Eastern Shore Rsrch Inst, LLC Fairhope, Alabama | |
| Erciyes University Cardiology Kayseri, | |
| Erciyes Üniversitesi Hastanesi- Kardiyoloji Kayseri, | |
| Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji Eskişehir, | |
| Evangelismos Hospital Athens, | |
| Fiona Stanley Hospital Cardiology Murdoch, Western Australia | |
| Formed 2 Sp. z o.o. Oświęcim, Lesser Poland Voivodeship | |
| Fundación para la Investigación del Hospital Clínico de Valencia (INCLIVA) Valencia, | |
| Futuremeds Birmingham, | |
| G B Pant Institute of Postgraduate Medical Education and Research New Delhi, National Capital Territory of Delhi | |
| G B Pant Institute of Postgraduate Medical Education and Research New Delhi, National Capital Territory of Delhi | |
| GA Arrhythmia Cons & Rsch Inst Macon, Georgia | |
| Ganesh Shankar Vidyarthe Memorial (GSVM) Medical College Kanpur, Uttar Pradesh | |
| Ganesh Shankar Vidyarthe Memorial (GSVM) Medical College Kanpur, Uttar Pradesh | |
| Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt Thessaloniki, | |
| General Hospital of Chios "Skilitsio" - Cardiology Clinic Chios, | |
| General Hospital of Kalamata - Cardiology Department Kalamata, | |
| Gesundheitscentrum Mainz (Regner / Schmitt) Mainz, | |
| Government Siddhartha Medical College & Government General Hospital, Vijayawada Vijayawada, Andhra Pradesh | |
| Guru Nanak CARE Hospitals Hyderabad, Telangana | |
| H Virgen del Camino_Sanlúcar_Medicina Interna Sanlúcar de Barrameda, | |
| Hospital Gregorio Maranon Madrid, | |
| Hospital Raja Perempuan Zainab II Kelantan, | |
| Hospital Raja Perempuan Zainab II Kelantan, | |
| Hospital Raja Permaisuri Bainun Ipoh Ipoh, Perak | |
| Hospital Ramon Y Cajal Madrid, | |
| Hospital Serdang Kajang, Selangor | |
| Hospital Sultanah Aminah Johor Bahru, Johor | |
| Hospital Sultanah Aminah Johor Bahru, Johor | |
| Hospital Sultanah Bahiyah Alor Star, Kedah | |
| Hospital Tengku Ampuan Afzan Kuantan, Pahang | |
| Hospital Universitario Puerta de Hierro Majadahonda Majadahonda, | |
| Hospital Universitario de Salamanca Salamanca, | |
| Hospital Universitario de Salamanca Salamanca, | |
| Hospital Vithas Sevilla Castilleja de la Cuesta, | |
| Hospital da Luz Lisbon, | |
| Illawarra Heart Health Centre Wollongong, New South Wales | |
| Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman Gdynia, Pomeranian Voivodeship | |
| Innera s.r.o. Benešov, | |
| Institut de Cardiologie de Montreal Montreal, Quebec | |
| Instituto de Investigaciones Clinicas Quilmes SRL Buenos Aires, | |
| Investigaciones Clínicas Tucumán San Miguel de Tucumán, Tucumán., | |
| Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry, Tamil Nadu | |
| Jawaharlal Nehru Medical College and Hospital Aligarh, Uttar Pradesh | |
| Jawaharlal Nehru Medical College and Hospital Aligarh, Uttar Pradesh | |
| John Hunter Hospital New Lambton, New South Wales | |
| John Hunter Hospital - Cardiovascular Department New Lambton Heights, New South Wales | |
| KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre Karnataka, | |
| KLES Dr. Prabhakar Kore Hospital & Medical Research Centre Belagavi, Karnataka | |
| Kansas City VA Medical Center Kansas City, Missouri | |
| Kansas City VA Medical Center Kansas City, Missouri | |
| Kardio Life Włocławek, Kuyavian-Pomeranian Voivodeship | |
| Kardio Life - Tomasz Borkowski Włocławek, | |
| Kardiologicka ambulance Brno s.r.o. Brno, | |
| Kardiologická ambulance MUDr. Ferkl s.r.o. Trutnov, | |
| Kardiologisch-Angiologische Praxis Herzzentrum Bremen Bremen, | |
| Kardiopraxis Schirmer Kaiserslautern, | |
| Kasturba Medical College and Hospital, Manipal Udupi, Karnataka | |
| Kasturba Medical College and Hospital, Manipal Udupi, Karnataka | |
| Kath. Hospitalvereinigung Thüringen gGmbH - KKH St. Johann Nepomuk - Innere Med. II Erfurt, | |
| King George Hospital Visakhapatnam, Andhra Pradesh | |
| Kocaeli Üniversitesi Hastanesi- Kardiyoloji Kocaeli, | |
| Konstantopouleio G.H. of Athens, "Agia Olga" Athens, | |
| Linden sp. z o.o. sp. k. Krakow, Lesser Poland Voivodeship | |
| Long Island Cardiovascular Consultants PC Lake Success, New York | |
| MC Hera EOOD - Sofia Sofia, | |
| MD Medical Research Oxon Hill, Maryland | |
| MEDICON a.s. Prague, | |
| MHAT Haskovo AD Haskovo, | |
| MHAT Heart and Brain EAD - Pleven, Cardiology Pleven, | |
| MHAT Puls AD, Cardiology Department Blagoevgrad, | |
| MVZ CCB Frankfurt Und Main-Taunus GbR Frankfurt, | |
| MVZ im Altstadt-Carree Fulda GmbH - Zentrum für klinische Studien Fulda, | |
| Malla Reddy Narayana Multispeciality Hospital Hyderabad, Telangana | |
| Manipal Hospital, Mysuru Mysuru, Karnataka | |
| Maryland Cardiovascular Specialists - Baltimore Baltimore, Maryland | |
| Medical Center Synexus Sofia EOOD Sofia, | |
| Medical center ISUL - Tsaritsa Yoanna EOOD Sofia, | |
| Metropolitan General Hospital Healthcare Facilities Operation And Management Single Member S.A. - Cardiology Clinic Athens, | |
| Millennium Cardiology Farmington Hills, Michigan | |
| Montreal General Hospital Montreal, Quebec | |
| Mount Sinai Hosp at NYC New York, New York | |
| Naval Hospital of Athens Athens, | |
| Naval Hospital of Athens - Clinic of Cardiology Athens, | |
| Nemocnice AGEL Třinec-Podlesí a.s. Třinec, | |
| Ninewells Hospital Dundee, | |
| Northwell Health Phys Cardio Riverhead, New York | |
| Northwest Heart Center Tomball, Texas | |
| Ocala Cardiovascular Research Ocala, Florida | |
| Ordinace pro choroby srdce Chomutov, | |
| Ormond Beach Clinical Research Ormond Beach, Florida | |
| Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji Warsaw, | |
| Peterborough City Hospital Peterborough, Cambridgeshire | |
| PharmaTex Research Amarillo, Texas | |
| PharmaTex Research Amarillo, Texas | |
| Polyclinique Vauban Valenciennes, | |
| Pratia S.A. Jelenia Góra, Lower Silesian Voivodeship | |
| Private Practice Leadership LLC. Katy, Texas | |
| Prywatna Praktyka Lekarska Anna Chudoba Żyrardów, | |
| Raigmore Hospital Inverness, | |
| Rajiv Gandhi Super Speciality Hospital New Delhi, National Capital Territory of Delhi | |
| Renown Regional Medical Center Reno, Nevada | |
| Rhythm Heart Institute Vadodara, Gujarat | |
| S.P. Medical College & Associated Group of Hospitals Bikaner, | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Pulawach Puławy, Lublin Voivodeship | |
| Sanatorio Esperanza Esperanza, Santa Fe, | |
| Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Saul Vizel Pro. Med. Corp Cambridge, Ontario | |
| Sengupta Hospital and Research Institute Nagpur, Maharashtra | |
| Sengupta Hospital and Research Institute Nagpur, Maharashtra | |
| Sentara Health Research Center Norfolk, Virginia | |
| Sherman Clinical Research Sherman, Texas | |
| Sir Ganga Ram Hospital New Delhi, | |
| Sismanogleio General Hospital - Cardiology Department Marousi, | |
| South California Heart Spc Pasadena, California | |
| Sri Jayadeva Institute of Cardiovascular Sciences & Research Bengaluru, Karnataka | |
| Sri Jayadeva Institute of Cardiovascular Sciences & Research Bengaluru, Karnataka | |
| St John's Medical College Hospital Bengaluru, Karnataka | |
| St John's Medical College Hospital Bengaluru, Karnataka | |
| St Johns Ctr Clin Rsch-St. Aug Saint Augustine, Florida | |
| St. Richard's Hospital_Cardiology Chichester, West Sussex | |
| Svitavska nemocnice Kardiologie Svitavy, | |
| Szpitale Pomorskie Sp. z o.o. Gdynia, Pomeranian Voivodeship | |
| Szpitale Pomorskie Sp. z o.o. Gdynia, Pomeranian Voivodeship | |
| T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan Adana, | |
| The Cardiologists Pty Ltd Epping, Victoria | |
| The Cardiologists Pty Ltd Epping, Victoria | |
| The Prince Charles Hospital Chermside, Queensland | |
| The Prince Charles Hospital Chermside, Queensland | |
| Trakya University Edirne, | |
| Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji Edirne, | |
| Trialmed Sp. z o. o. Piotrkow Trybunalski, | |
| Trialmed Sp. z o. o. Piotrkow Trybunalski, | |
| U.G.H of Athens "Attikon" Chaidari, Athens, | |
| U.G.H of Athens "Attikon" Chaidari, Athens, | |
| UCI Health Irvine, California | |
| UMHAT Sveta Anna Sofia AD, Clinic of Cardiology Sofia, | |
| UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology Plovdiv, | |
| UMHATEM N.I. Pirogov EAD Sofia, | |
| Uniklinik TU Dresden - Herzzentrum Dresden GmbH Dresden, | |
| Univ Gen Hospital Larisa, Cardiology Medicine Clinic Larissa/Thessaly, | |
| Univ of Pennsylvania Hospital Philadelphia, Pennsylvania | |
| University Malaya Medical Centre Lembah Pantai, | |
| University Malaya Medical Centre Lembah Pantai, | |
| University of Calgary_Calgary Calgary, Alberta | |
| University of North Carolina at Chapel Hill Chapel Hill, North Carolina | |
| University of Texas Southwestern Medical Center Dallas, Texas | |
| Universität des Saarlandes - Innere Med. III Homburg, | |
| Universitätsklinikum Freiburg - Medical Center Freiburg im Breisgau, | |
| Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi Lodz, Łódź Voivodeship | |
| Uniwersytecki Szpital Kliniczny W Poznaniu Poznan, | |
| Uniwersytecki Szpital Kliniczny W Poznaniu Poznan, | |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Bialystok, | |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Bialystok, | |
| UofL Health Care Outpatient Louisville, Kentucky | |
| Valley Clinical Trials, Inc. Northridge, California | |
| Valley Clinical Trials, Inc. Northridge, California | |
| Vardhaman Mahavir Medical College & Safdarjung Hospital New Delhi, National Capital Territory of Delhi | |
| Velocity Clin Rsrch - Savannah Savannah, Georgia | |
| Vijan Hospital & Research Centre Nashik, Maharashtra | |
| Vijan Hospital & Research Centre Nashik, Maharashtra | |
| Villoo Poonawalla Memorial Hospital Pune, Maharashtra | |
| Virginia Commonwealth University Richmond, Virginia | |
| Vojenská nemocnice Brno p.o. Brno, | |
| Washington University St Louis, Missouri | |
| Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika Lodz, | |
| Zanamed Medical Clinic Sp. z o.o. Lublin, | |
| Zentrum fuer klinische Studien Suedbrandenburg GmbH Elsterwerda, |
The CONFORM Pivotal Trial
Sarah Gallagher - sgallagher@conformalmedical.com
NCT05147792
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Inclusion Criteria:
• Male or non-pregnant female aged ≥18 years
• Documented non-valvular AF (paroxysmal, persistent, or permanent)
• High risk of stroke or systemic embolism, defined as CHA2DS2-VASc score of ≥ 3
• Has an appropriate rationale to seek a non-pharmacologic alternative to long-term oral anticoagulation
• Deemed by the site investigator to be suitable for short term oral anticoagulation therapy but deemed less favorable for long-term oral anticoagulation therapy.
• Deemed appropriate for LAA closure by the site investigator and a clinician not a part of the procedural team using a shared decision-making process in accordance with standard of care
• Able to comply with the protocol-specified medication regimen and follow-up evaluations
• The subject (or legally authorized representative, where allowed) has been informed of the nature of the study, agrees to its provisions, and has provided written informed consent approved by the appropriate institutional review board (IRB)/Regional Ethics Board (REB)/Ethics Committee (EC).
Exclusion Criteria:
• Pregnant or nursing patients and those who plan pregnancy in the period up to one year following the index procedure. Female patients of childbearing potential must have a negative pregnancy test (per site standard test) within 7 days prior to index procedure.
• Anatomic conditions that would prevent performance of an LAA occlusion procedure (e.g., atrial septal defect (ASD) requiring closure, high-risk patent foramen ovale (PFO) requiring closure, a highly mobile inter-atrial septal aneurysm precluding a safe TSP, presence of a PFO/ASD closure device, history of surgical ASD repair or history of surgical LAAO closure)
• Atrial fibrillation that is defined by a single occurrence or that is transient or reversible (e.g., secondary thyroid disorders, acute alcohol intoxication, trauma, recent major surgical procedures)
• A medical condition (other than atrial fibrillation) that mandates long-term oral anticoagulation (e.g., history of unprovoked deep vein thrombosis or pulmonary embolism, or prosthetic mechanical heart valve)
• History of bleeding diathesis or coagulopathy, or patients in whom antiplatelet and/or anticoagulant therapy is contraindicated
• Documented active systemic infection
• Symptomatic carotid artery disease (defined as \>50% stenosis with symptoms of ipsilateral transient or visual TIA evidenced by amaurosis fugax, ipsilateral hemispheric TIAs or ipsilateral stroke); if subject has a history of carotid stent or endarterectomy the subject is eligible if there is \<50% stenosis noted at the site of prior treatment
• Recent (within 30 days of index procedure) or planned (within 60 days post-procedure) cardiac or major non-cardiac interventional or surgical procedure
• Recent (within 30 days of index procedure) stroke or transient ischemic attack
• Recent (within 30 days of index procedure) myocardial infarction
• Vascular access precluding delivery of implant with catheter-based system
• Severe heart failure (New York Heart Association Class IV)
• Prior cardiac transplant, history of mitral valve replacement or transcatheter mitral valve intervention, or any prosthetic mechanical valve implant
• Renal insufficiency, defined as estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73 m2 (by the Modification of Diet in Renal Disease equation)
• Platelet count \<75,000 cells/mm3 or \>700,000 cells/mm3, or white blood cell count \<3,000 cells/mm3
• Known allergy, hypersensitivity or contraindication to aspirin, heparin, or that would preclude any P2Y12 inhibitor therapy, or to device materials (e.g., nickel, titanium), or the subject has contrast sensitivity that cannot be adequately pre-medicated
• Actively enrolled or plans to enroll in a concurrent clinical study in which the active treatment arm may confound the results of this trial
• Unable to undergo general anesthesia
• Known other medical illness or known history of substance abuse that may cause non-compliance with the protocol or protocol-specified medication regimen, confound the data interpretation, or is associated with a life expectancy of less than 5 years
• A condition which precludes adequate transesophageal echocardiographic assessment Echo exclusion criteria:
• Left atrial appendage anatomy which cannot accommodate a commercially available control device or the CLAAS Implant per manufacturer IFU (e.g., the anatomy and sizing must be appropriate for both the investigational (CLAAS) and a commercially available device in order to be enrolled in the trial)
• Intracardiac thrombus or dense spontaneous echo contrast consistent with thrombus, as visualized by TEE
• Left ventricular ejection fraction (LVEF) \<30%
• Moderate or large pericardial effusion \>10 mm or symptomatic pericardial effusion, signs or symptoms of acute or chronic pericarditis, or evidence of tamponade physiology
• Atrial septal defect that warrants closure
• High risk patent foramen ovale (PFO), defined as an atrial septal aneurysm (excursion \>15 mm or length \> 15 mm) or large shunt (early \[within 3 beats\] and/or substantial passage of bubbles, e.g., \>20)
• Moderate or severe mitral valve stenosis (mitral valve area \<1.5 cm2)
• Complex atheroma with mobile plaque of the descending aorta and/or aortic arch
• Evidence of cardiac tumor
DEVICE: CLAAS, DEVICE: WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder
Atrial Fibrillation, Stroke
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Show 93 locations
Study Locations
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| Location | Contacts |
|---|---|
| AKFA Medline Olmazor, Tashkent | |
| Abrazo Arizona Heart Hospital Phoenix, Arizona | |
| AdventHealth Orlando Orlando, Florida | Chantie Garvey - (chantie.garvey@adventhealth.com) |
| AdventHealth Tampa Tampa, Florida | Daniel Robledo - (daniel.robledo@adventhealth.com) |
| Albany Medical Center / Capital Cardiology Associates Albany, New York | Chris Chapman - (cchapman@capitalcardiology.com) |
| Arizona Heart Arrhythmia Associates Phoenix, Arizona | Helen Foughi - (hfoughi@insightmedr.com) |
| Ascension St. Vincent - Carmel, IN Indianapolis, Indiana | |
| Ascension St. Vincent's Jacksonville Jacksonville, Florida | |
| Asklepios Klinik-Altona Hamburg, | Larissa Mota Balduino - (l.mota@asklepios.com) |
| Banner University Medical Center Phoenix Phoenix, Arizona | Erin Downey - (ErinDowney@Arizona.edu) |
| Baptist Health Care - Pensacola Pensacola, Florida | Bridget Lane - (bridget.lane@bhcpns.org) |
| Baptist Hospital of Miami Miami, Florida | Maria Ardid - (mariaar@baptisthealth.net) |
| Baylor Scott & White Research Institute Dallas, Texas | Emmitt Lavergne - (Emmitt.Lavergne@BSWHealth.org) |
| Baystate Medical Center Springfield, Massachusetts | Christine Callahan - (Christine.Callahan@baystatehealth.org) |
| Bellin Health Green Bay, Wisconsin | Katherine Guilliams - (katherine.Guilliams@emplifyhealth.org) |
| CHI Health / CommonSpirit Research Institute Omaha, Nebraska | |
| CHRISTUS Health Tyler, Texas | Jamie-Crystal Wylie - (jamiecrystal.wylie@christushealth.org) |
| CHU La Timone, Marseille Marseille, | Aurélie Blondelon - (aurelie.blondelon@ap-hm.fr) |
| CHU de Bordeaux Bordeaux, | Amandine Ruissel - (amandine.ruissel@chu-bordeaux.fr) |
| CHU de Toulouse Toulouse, | Asmae Hammouda - (hammouda.a@chu-toulouse.fr) |
| Cardiovasculäres Centrum Frankfurt Frankfurt, | Sabine de Bruijn - (s.debruijn@cvcfrankfurt.de) |
| Carilion Clinic Roanoke, Virginia | Breanne Dao - (bldao@carilionclinic.org) |
| Catholic Medical Center Manchester, New Hampshire | |
| Centracare Heart and Vascular Center Saint Cloud, Minnesota | |
| Chapidze Heart Disease Center Tbilisi, | |
| Chippenham Hospital Richmond, Virginia | Ariana Dickens - (Ariana.Dickens@hcahealthcare.com) |
| Clinique Pasteur, Toulouse Toulouse, | Fréderique Petit - (fpetit@clinique-pasteur.com) |
| Community Memorial Hospital Ventura Ventura, California | Marisa Grant - (marisa@siteresearchmgmt.com) |
| Cooper University - Heart House Haddon Heights, New Jersey | Kaitlyn Downey - (KDowney@hearthousenj.com) |
| Corewell Health Grand Rapids, Michigan | |
| Deborah Heart and Lung Browns Mills, New Jersey | Luot Lewis - (LewisL@Deborah.org) |
| Elisabeth Krankenhaus Essen, | Vanessa Hüning - (v.huening@contilia.de) |
| Emory University Atlanta, Georgia | Katie Shin - (Katie.shin@emory.edu) |
| Erlanger Health System Chattanooga, Tennessee | |
| Grandview Medical Center Birmingham, Alabama | Kristy Raco - (kristy.raco@grandviewhealth.com) |
| HCA Grand Strand Myrtle Beach, South Carolina | Carley Brandli - (Carley.Brandli@hcahealthcare.com) |
| Hackensack University Medical Center Hackensack, New Jersey | |
| Hartford Health Care St. Vincent's Medical Center Bridgeport, Connecticut | Jesse Cardona - (Jesse.cardona@hhchealth.org) |
| Henry Ford Providence Southfield Hospital Southfield, Michigan | Candice Edillo - (cedillo1@hfhs.org) |
| Henry Ford St. John Hospital Grosse Pointe Woods, Michigan | Heather Metcalfe - (hmetcal1@hfhs.org) |
| HonorHealth Scottsdale, Arizona | Ethan Ashley - (eashley@honorhealth.com) |
| Houston Methodist Houston, Texas | Chinwe Ngumezi - (ccngumezi@houstonmethodist.org) |
| Huntington Hospital Huntington, New York | Samia Solh - (Samia.Solh@huntingtonhealth.org) |
| Institut Cardiovasculaire Paris Sud Massy, | Séverine Roger - (s.roger@icps.com.fr) |
| Israeli-Georgian Medical Research Clinic Helsicore Tbilisi, | |
| Johns Hopkins University Baltimore, Maryland | Michele Martucci - (mmill148@jmi.edu) |
| Kansas City Cardiac Arrhythmia Research, LLC Overland, Missouri | Rachael Koeppe - (rachael.koeppe@hcahealthcare.com) |
| Lahey Hospital & Medical Centeer Burlington, Massachusetts | Jean Byrne - (jean.byrne@lahey.org) |
| Lankenau Heart Institute Wynnewood, Pennsylvania | Lucy Delp - (delpl@mlhs.org) |
| Largo Medical Center Upper Marlboro, Maryland | Holly Lynn Grospitch - (HollyLynn.Grospitch@hcahealthcare.com) |
| Lexington Medical Center West Columbia, South Carolina | Quinn Cirillo - (sqcirillo@lexhealth.org) |
| Lifespan Health System Providence, Rhode Island | |
| Loma Linda University Health Loma Linda, California | Tina Ramirez - (tiramirez@llu.edu) |
| M Health Fairview St. John's Hospital Maplewood, Minnesota | Beth Jorgenson - (beth.jorgenson@fairview.org) |
| MedStar Union Memorial Hospital Baltimore, Maryland | Keith Moyer - (Keith.T.Moyer@medstar.net) |
| Medstar Washington Hospital Center Washington D.C., District of Columbia | Nebu Alexander - (nebu.alexander@medstar.net) |
| Memorial Hermann Memorial City Medical Center Houston, Texas | Maddie Peek - (maddie@whactc.com) |
| Midwest Cardiovascular Institute Naperville, Illinois | Sherri McCoy - (Sherri.McCoy@cardio.com) |
| Mission Hospital Asheville, North Carolina | Christina Riggsbee - (christina.riggsbee@hcahealthcare.com) |
| Mount Sinai Hospital New York, New York | Kyle Reed - (Kyle.Reed@mssm.edu) |
| Nemocnice Na Homolce Prague, | |
| New Mexico Heart Institute Albuquerque, New Mexico | LaTasha Johnson - (latasha.johnson@lovelace.com) |
| North Mississippi Medical Center Tupelo, Mississippi | Kristin Eads - (KEads@nmhs.net) |
| Northside Hospital, Inc Atlanta, Georgia | Troy Crain - (troy.crain@northside.com) |
| Ohio Health Research Institute Columbus, Ohio | |
| Pacific Heart Institute Santa Monica, California | Alette Laughton - (research@pacificheart.com) |
| Piedmont Health Institute Atlanta, Georgia | Megan Kopp - (Megan.Kopp@piedmont.org) |
| Pima Heart & Vascular Tucson, Arizona | Salma Blum - (Salma.Blum@tmcaz.com) |
| Prisma Health Greenville, South Carolina | Amy Wolfe - (Amy.Wolfe@PrismaHealth.org) |
| Promedica Toledo Hospital Toledo, Ohio | Sonya Inderrieden - (Sonya.Inderrieden@ProMedica.org) |
| Republican Specialized Center for Surgery named after V. Vakhidov Chilanzar, Tashkent | |
| Saint Luke's Hospital of Kansas City Kansas City, Missouri | Cheryl Rutherford - (cjrutherford@saint-lukes.org) |
| Sarasota Memorial Health Care System Sarasota, Florida | Kristen Sangmaster - (kristen-sangmaster@smh.com) |
| Sentara Norfolk Norfolk, Virginia | |
| South Denver Cardiology Associates Littleton, Colorado | Sarah Neilsen - (sneilsen@southdenver.com) |
| St. Bernard's Medical Center Jonesboro, Arkansas | Kayla Rubino - (krubino@dnairresearch.com) |
| Tbilisi Heart Center Tbilisi, | |
| Tbilisi Heart and Vascular Clinic Tbilisi, | |
| Tennova Healthcare - Turkey Creek Medical Center Knoxville, Tennessee | Juliana Bailey - (juliana.bailey@tennova.com) |
| Terrebone - Cardiovascular Institute of the South Houma, Louisiana | Vicky Parfait - (vicky.parfait@cardio.com) |
| TriHealth Cincinnati, Ohio | Marta McClellan - (Marta_McClellan@trihealth.com) |
| Trident Medical Center North Charleston, South Carolina | Danielle Pagan - (danielle.pagan@hcahealthcare.com) |
| UPMC Harrisburg Harrisburg, Pennsylvania | Matthew Rutt - (ruttmd4@upmc.edu) |
| USF - Tampa General Hospital Tampa, Florida | Jacky He - (jackyhe@usf.edu) |
| University of Buffalo / Kaleida Health Buffalo, New York | Lindsay Moshides - (lmoshide@buffalo.edu) |
| University of Iowa Iowa City, Iowa | Trisha Elliott - (trisha-elliott@uiowa.edu) |
| University of Kansas Medical Center Kansas City, Kansas | Grace Millington - (gmillington@kumc.edu) |
| University of Nebraska Medical Center Omaha, Nebraska | Melissa Howard - (mehoward@unmc.edu) |
| Vanderbilt University Medical Center Nashville, Tennessee | Amanda Caroll - (Amanda.carroll@vumc.org) |
| Virginia Commonwealth University Richmond, Virginia | Esoterica Berry - (Esoterica.Berry@vcuhealth.org) |
| Virginia Mason Medical Center Seattle, Washington | Jin Yoon - (jin.yoon@commonspirit.org) |
| Wellstar Kennestone Hospital Marietta, Georgia | Jennifer Cuvo - (Jennifer.Cuvo@wellstar.org) |
| West Virginia University Morgantown, West Virginia | Danielle Walden - (danielle.walden@wvumedicine.org) |
The Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART) (AID-HEART)
Benjamin VanTassell - bvantassell@vcu.edu
NCT06062966
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Inclusion Criteria:
* Primary diagnosis for the clinic visit is stage D heart failure being on chronic stable dose of inotrope therapy (dobutamine or milrinone for the previous 28 days)
* Prior documentation of impaired left ventricular systolic function (ejection fraction \<50%) at most recent assessment by any imaging modality (within 12 months)
* Stable dose of inotrope treatment without a recent hospitalization within the previous month
* Age ≥21 years and willing/able to provide written informed consent
* The patient is willing and able to comply with the protocol (i.e. self administration of the treatment, and exercise protocol).
* Screening plasma C-reactive protein levels \>2 mg/L
Exclusion Criteria:
* Concomitant clinically significant comorbidities including (but not limited to) acute coronary syndromes, uncontrolled hypertension or orthostatic hypotension, tachy- or brady-arrhythmias, acute or chronic pulmonary disease or neuromuscular disorders affecting respiration that would interfere with the execution, interpretation, or completion of the study
* Recent (previous 3 months) or planned resynchronization therapy (CRT), or valve surgeries
* Previous or planned implantation of left ventricular assist devices or heart transplant within the next 3 months
* Recent (\<14 days) use of immunosuppressive or anti-inflammatory drugs (including oral corticosteroids at a dose of prednisone equivalent of 0.5 mg/kg/day but not including inhaled or low dose oral corticosteroids or non-steroidal anti-inflammatory drugs)
* Chronic inflammatory disorder (including but not limited to rheumatoid arthritis, systemic lupus erythematosus)
* Active infection (of any type), including chronic/recurrent infectious disease (including HBV, HCV, and HIV/AIDS) - but excluding HCV+ with undetectable plasma RNA
* Prior (within the past 5 years) or current malignancy on targeted treatment - excluding carcinoma in situ \[any location\] or localized non-melanoma skin cancer
* Stage V kidney disease or on renal-replacement therapy
* Neutropenia (\<1,500/mm3 or \<1,000/mm3 in African-American patients)
* Pregnancy or breastfeeding
* Angina, hypertension, arrhythmias, electrocardiograph (ECG) changes, or other non-cardiac limitations that limit 6MWD obtained during the baseline testing
* Hypersensitivity to anakinra or to E. coli derived products DRUG: Anakinra
Heart Failure
Inotrope sensitivity, IL-1 Blockade, Subcutaneous (SC), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV, 6 Minute Walk Test (6MWT)
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Study Locations
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| Location | Contacts |
|---|---|
| Virginia Commonwealth University Richmond, Virginia | Azita Talasazah - (talasazah@vcu.edu) Benjamin Van Tassell - (bvantassell@vcu.edu) |
ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack (ARTEMIS)
Novo Nordisk - clinicaltrials@novonordisk.com
NCT06118281
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Key inclusion:
* Age 18 years or above at the time of signing the informed consent.
* Hospitalisation for acute myocardial infarction with evidence of type 1 myocardial infarction (MI) by invasive angiography performed at site with percutaneous coronary intervention (PCI) capabilities.
* ST-segment elevation myocardial infarction (STEMI) with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 12 hours before hospitalisation, at the investigator's discretion.
b) Electrocardiogram (ECG)-changes (in the absence of left ventricular hypertrophy or left bundle branch block): ST-segment elevation at the J point in at least two contiguous leads greater than or equal 0.25 (millivolt) mV in men less than 40 years, greater than or equal 0.2 mV in men greater than or equal 40 years, or greater than or equal 0.15 mV in women in leads V2-V3; and/or greater than or equal 0.1 mV in all other leads.
OR
* Non-ST-segment myocardial infarction with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 24 hours before hospitalisation, at the investigator's discretion. b) Rise and/or fall in car-diac troponin I or T with at least one value above the 99th percentile upper reference limit.
* Possibility for both randomisation and administration of the loading dose of study intervention as early as possible after invasive procedure, and latest within 36 hours of hospitalisation (time 0) for STEMI, and latest within 72 hours of hospitalisation (time 0) for NSTEMI.
* Presence of at least one of the following criteria confirmed based on the participant's medical records and/or medical history interview: a) Any prior MI. b) Prior coronary revascularisation. c) Diabetes mellitus treated with ongoing glucose-lowering agent(s). d)Known chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) greater than or equal to 15 and less than 60 milliliter per minute per 1.73 square meter (mL/min/1.73 m\^2). e) Prior ischaemic stroke. f) Known carotid disease or peripheral artery disease in the lower extremities. g) Multivessel coronary artery disease (current/prior). h) For STEMI patients only: anterior MI at index acute myocardial infarction (AMI)
Key exclusion:
* Use of fibrinolytic therapy for treatment of the current AMI.
* Chronic heart failure classified as being in New York Heart Association (NYHA) Class IV.
* Ongoing haemodynamic instability defined as any of the following: a) Killip Class III or IV. b) Sustained and/or symptomatic hypotension (systolic blood pressure less than 90 millimeters of mercury (mmHg)).
* Severe kidney impairment defined as any of the following: a) eGFR less than 15 mililitre per minute per 1.73 m\^2. b) Chronic haemodialysis or peritoneal dialysis.
* Known alanine aminotransferase (ALT) greater than 8 x upper limit of normal (reference range) (ULN).
* Severe hepatic disease defined as at least one of the following: a) Previously known or current hepatic encephalopathy (clinical evaluation). b) Previously known or current ascites (clinical eval-uation). c) Jaundice (clinical evaluation). d) Previous oesophageal/gastric variceal bleeding. c) Known hepatic cirrhosis.
* Major cardiac surgical (including but not restricted to coronary artery bypass graft surgery (CABG)), non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days or any major surgical procedure planned at the time of randomisation or as treatment for the current AMI (CABG). Deferred (staged)percutaneous coronary intervention for a non-culprit vessel identified during the current AMI is allowed.
* Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
* Known (acute or chronic) hepatitis B or hepatitis C.
* History or evidence of untreated latent tuberculosis (TB) such as (but not limited to): a) History of a positive TB test or chest X-ray compatible with latent TB; and TB treatment initiated less than 28 days prior to randomisation. b) Participants with TB risk factors but unwilling to undergo TB treatment if confirmed positive for latent TB based on central laboratory test at baseline (visit 2).
DRUG: Ziltivekimab, DRUG: Placebo
Cardiovascular Risk, Acute Myocardial Infarction (AMI)
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Study Locations
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| Location | Contacts |
|---|---|
| "AHEPA" University General Hospital of Thessaloniki Thessaloniki, | |
| "AHEPA" University General Hospital of Thessaloniki Thessaloniki, | |
| "Hygeia" General Hospital of Athens Athens, | |
| "Sotiria" Thoracic Diseases Hospital of Athens Athens, | |
| "UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology Sofia, | |
| 'G. Gennimatas' General Hospital of Athens Athens, | |
| 'G. Gennimatas' General Hospital of Athens - Cardiology Department Athens, | |
| 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ Lublin, | |
| 10 Wojskowy Szpital Kliniczny z Poliklinika - Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Bydgoszczy Bydgoszcz, | |
| 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu Wroclaw, | |
| A.O.U Città della Salute e della Scienza di Torino Torino, | |
| A.O.U Città della Salute e della Scienza di Torino Torino, | |
| A.O.U. Ferrara, Sant'Anna Cona (Ferrara), Fe | |
| AORN "Sant'Anna e San Sebastiano" Caserta, Ce | |
| AOU Maggiore della Carità di Novara - Dipartimento Toraco-Cardio-Vascolare - SCDU Cardiologia Novara, | |
| AOUI Verona Verona, Vr | |
| AOUI Verona Verona, Vr | |
| ASSOCIAÇÃO LAR SÃO FRANCISCO DE ASSIS NA PROVIDÊNCIA DE DEUS - Hospital Regional de Presidente Prudente Presidente Prudente, São Paulo | |
| AUSL Romagna - Distretto Rimini - Ospedale Infermi Rimini, | |
| AUSL Toscana Sud Est - Ospedale Misericordia Grosseto Grosseto, | |
| Aakash Healthcare Super Speciality Hospital New Delhi, | |
| Aalborg Universitetshospital Hjertemedicinsk Afdeling Gistrup, | |
| Aalborg Universitetshospital Kardiologisk Afdeling Aalborg, | |
| Aarhus Universitetshospital, Hjertesygdomme Aarhus N, | |
| Abbott Northwestern Hospital Minneapolis, Minnesota | |
| Acibadem City Clinic UMHAT EOOD, Cardiology Sofia, | |
| Acibadem City Clinic UMHAT Tokuda EAD, Cardiology Sofia, | |
| Adana Şehir Eğitim ve Araştırma Hastanesi Adana, | |
| Adrian Costa Clinical Trials Centre Geelong, Victoria | |
| Advanced Cardiovascular, LLC Alexander City, Alabama | |
| Advanced Heart & Vein Center Thornton, Colorado | |
| Advanced Heart Care LLC Bridgewater, New Jersey | |
| Adventist Healthcare Shady Grove Medical Center Rockville, Maryland | |
| Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji Afyonkarahisar, | |
| Ajou University Hospital Suwon, | |
| Akdeniz Üniversitesi Hastanesi-Kardiyoloji Antalya, | |
| Alexandra General Hospital, Therapeutic Clinic Athens, | |
| All India Institute of Medical Sciences (AIIMS) New Delhi, | |
| All India Institute of Medical Sciences (AIIMS) New Delhi, | |
| All India Institute of Medical Sciences (AIIMS), Bhubaneswar Bhubaneswar, Odisha | |
| All India Institute of Medical Sciences (AIIMS), Nagpur Nagpur, Maharashtra | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| Amper Kliniken AG - Helios Amper-Klinikum Dachau - Kardiologie Dachau, | |
| Amphia Ziekenhuis Breda, | |
| AnMed Health Clinical Research Anderson, South Carolina | |
| Ankara Bilkent Şehir Hastanesi-Kardiyoloji Ankara, | |
| Ankara Sehir Hastanesi Cardiology Ankara, | |
| Ankara Üniversitesi Tıp Fakültesi İbni Sina Hastanesi- Kardiyoloji Ankara, Altindag | |
| Antalya Eğitim ve Araştırma Hastanesi- Kardiyoloji Muratpasa/ Antalya, | |
| Ap-Hp-Hopital Bichat-Claude Bernard Paris, | |
| Ap-Hp-Hopital Europeen Georges Pompidou Paris, | |
| Aphp-Hopital La Pitie Salpetriere Paris, | |
| Apollo Multispeciality Hospital, Kolkata Kolkata, West Bengal | |
| Apollo Multispeciality Hospital, Kolkata Kolkata, West Bengal | |
| Arcispedale S Maria Nuova Azienda ULSS-IRCCS Reggio Emilia, | |
| Arkansas Cardiology Clinic Little Rock, Arkansas | |
| Arneja Heart & Multispeciality Hospital Nagpur, Maharashtra | |
| Asahi General Hospital＿Cardiology Chiba, | |
| Asan Medical Center Seoul, | |
| Ascension Sacred Heart Pensacola, Florida | |
| Ascension St. Mary's Research Institute - Michigan Southfield, Michigan | |
| Asklepieion General Hospital - Cardiology Clinic Athens/Voula, | |
| Asklepios Klinik Langen - Medizinische Klinik I Langen, | |
| Assistance Publique Hopitaux de Marseille-Hopital de La Timone Marseille, | |
| Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista Bragança Paulista, São Paulo | |
| Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital New Delhi, National Capital Territory of Delhi | |
| Atlanta VAMC Decatur, Georgia | |
| AtlantiCare Regional Medical Center Pomona, New Jersey | |
| Augusta University Augusta, Georgia | |
| Augusta University Augusta, Georgia | |
| Aultman Hospital Canton, Ohio | |
| Aurora St. Luke's Medi Ctr Milwaukee, Wisconsin | |
| Austin Heart San Marcos, Texas | |
| Austin Hospital Heidelberg, Victoria | |
| Azienda Ospedaliera Santa Maria Degli Angeli Pordenone, PN | |
| Azienda Ospedaliera Universitaria Careggi Florence, | |
| Azienda Ospedaliera Universitaria Federico II di Napoli Naples, | |
| Azienda Ospedaliera di Parma Parma, | |
| Azienda Ospedaliera di Parma Parma, | |
| Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli Naples, | |
| Azienda Ospedaliero - Universitaria Sant'Andrea Rome, | |
| Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara Novara, | |
| Azienda Ospedaliero-Universitaria Renato Dulbecco Catanzaro, Cz | |
| Azienda Ospedaliero-Universitaria SS Antonio e Biagio e Cesare Arrigo Alessandria, | |
| Azienda Sanitaria Friuli Occidentale - Azienda Ospedaliera Santa Maria Degli Angeli - SC Cardiologia Pordenone Pordenone, PN | |
| Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia Torino, To | |
| Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia Torino, To | |
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Bergamo, | |
| Azienda Unità Sanitaria Locale Di Piacenza - Cardiologia Piacenza, | |
| B M Birla Heart Research Centre Kolkata, West Bengal | |
| B M Birla Heart Research Centre Kolkata, West Bengal | |
| BG Klinikum Unfallkrankenhaus Berlin GmbH - Klinik für Kardiologie Berlin, | |
| Baptist Clin Res Institute Memphis, Tennessee | |
| Baptist Heart Specialists Jacksonville, Florida | |
| Baptist Hospital Cardiology Pensacola, Florida | |
| Barts Heart Centre London, | |
| Batra Hospital and Medical Research Center New Delhi, National Capital Territory of Delhi | |
| Batra Hospital and Medical Research Center New Delhi, National Capital Territory of Delhi | |
| Baylor Scott & White Res Inst Plano, Texas | |
| Beijing Anzhen Hospital, Capital Medical University Beijing, Beijing Municipality | |
| Beijing Anzhen Hospital, Capital Medical University Beijing, Beijing Municipality | |
| Bellvitge Universitary Hospital Badalona, | |
| Birmingham VA Medical Center Birmingham, Alabama | |
| Blackpool Victoria Hospital Blackpool, | |
| Bon Secours St. Mary's Hospital of Richmond, LLC Richmond, Virginia | |
| Bravis Zkh Roosendaal Roosendaal, | |
| Bremer Institut für Herz- und Kreislaufforschung (BIHKF) Bremen, | |
| Bridgeport Hospital Bridgeport, Connecticut | |
| Brigham & Women's Hospital Boston, Massachusetts | |
| Bursa Yüksek İhtisas Eğitim ve Araştırma Merkezi-Kardiyoloji Bursa, | |
| Bursa Şehir Hastanesi- Kardiyoloji Bursa, | |
| CHU de Quebec-Universite-Laval,HDQ Québec, | |
| CHUM Centre de Recherch Hotel-Dieu Montreal, Quebec | |
| CHUM Centre de Recherch Hotel-Dieu Montreal, Quebec | |
| CIP Centro Integrado de Pesquisas do Hospital de Base São José do Rio Preto, São Paulo | |
| CIP Centro Integrado de Pesquisas do Hospital de Base São José do Rio Preto, São Paulo | |
| CISSS de Lanaudiere - Centre hospitalier De Lanaudiere Saint-Charles-Borromée, Quebec | |
| CISSSL Hôsp Pierre-Le Gardeur Terrebonne, Quebec | |
| CIUSS Hopit de Chicoutimi Chicoutimi, Quebec | |
| CV Research of Knoxville Powell, Tennessee | |
| Cairns Base Hospital Cairns, Queensland | |
| Cangzhou Central Hospital Cangzhou Shi, Hebei | |
| Cangzhou Central Hospital Cangzhou Shi, Hebei | |
| Canisius-Wilhelmina ziekenhuis Nijmegen, | |
| Cardio. Consult. of S. GA Thomasville, Georgia | |
| Cardiolg Assoc Rsch LLC_Tupelo Tupelo, Mississippi | |
| Cardiolg Assoc Rsch LLC_Tupelo Tupelo, Mississippi | |
| Cardiology Associates of Fairfield County Stamford, Connecticut | |
| Cardiology Associates_Asheville Asheville, North Carolina | |
| Cardiología Hospital J. M. Ramos Mejia Buenos Aires, | |
| Cardiovascular Associates of the Delaware Valley Sewell, New Jersey | |
| Catharina Zkh Eindhoven - Cardiologie Eindhoven, | |
| Cellitinnen-Krankenhaus St. Vinzenz Köln - Kardiologie Cologne, | |
| Central Arkansas Veteran's Healthcare System Little Rock, Arkansas | |
| Central India Cardiology Hospital and Research Institute Nagpur, Maharashtra | |
| Centre Hospitalier Regional Universitaire de Tours-Hopital Trousseau Chambray-lès-Tours, | |
| Centre Hospitalier Saint Joseph Saint Luc Lyon, | |
| Centre Hospitalier Sud Francilien Corbeil-Essonnes, | |
| Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon La Tronche, | |
| Centre Hospitalier Universitaire de Besancon-Hopital Jean Minjoz Besançon, | |
| Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque Pessac, | |
| Centre Hospitalier Universitaire de Caen Normandie- Cote de Nacre Caen, | |
| Centre Hospitalier Universitaire de Lille-Institut Coeur Poumon Lille, | |
| Centre Hospitalier Universitaire de Nice-Hopital Pasteur Nice, | |
| Centre Hospitalier Universitaire de Poitiers Poitiers, | |
| Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil Toulouse, | |
| Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1 Toulouse, | |
| Centre hosp affilié univ rég Trois-Rivières, Quebec | |
| Centro Médico Nacional Siglo XXI Mexico City, | |
| Centro Privado de Cardiología San Miguel de Tucuimán, Tucumán Province | |
| Centro de Atención e Investigación Cardiovascular del Potosi (CICAP) San Luis Potosí City, | |
| Centro de Estudios Clinicos de Querétaro S.C. Santiago de Querétaro, Qro., Querétaro | |
| Centro de Estudios Clinicos de Querétaro S.C. Santiago de Querétaro, Qro., Querétaro | |
| Centro de Imagen y Tecnologia en Intervención Cardiovascular México, | |
| Centro de Investigación C.I.C.E 9 de Julio - Sanatorio 9 de Julio San Miguel de Tucumán, Tucumán Province | |
| Centro de Pesquisa Clínica do Hospital de Clínicas da Universidade Federal de Uberlândia Uberlândia, Minas Gerais | |
| Centro de atención e investigación cardiovascular del Potosí San Luis Potosí City, San Luis Potosí | |
| Cerrahpaşa Kardiyoloji Enstitüsü Istanbul, | |
| Chambersburg Hospital Chambersburg, Pennsylvania | |
| Chambersburg Hospital Chambersburg, Pennsylvania | |
| Charité - Campus Benjamin Franklin - Klinik für Kardiologie Berlin, | |
| Chattanooga Heart Institute Chattanooga, Tennessee | |
| Chattanooga Heart Institute Chattanooga, Tennessee | |
| China-Japan Friendship Hospital Beijing, | |
| China-Japan Friendship Hospital Beijing, | |
| China-Japan Union Hospital of Jilin University Changchun, Jilin | |
| China-Japan Union Hospital of Jilin University-Cardiology Changchun, Jilin | |
| Chinese Academy of Medical Sciences Fuwai Hospital Beijing, Beijing Municipality | |
| Chippenham Medical Center Richmond, Virginia | |
| Chonnam National University Hospital Gwangju, | |
| Chopda Medicare and Research Centre Pvt. Ltd. Nashik, Maharashtra | |
| Christiana Care Health Services, Inc. Newark, Delaware | |
| Christus Heart and Vascular Institute Tyler, Texas | |
| Chru de Nancy - Hopital Brabois Vandœuvre-lès-Nancy, | |
| Chungbuk National University Hospital Cheongju-si, | |
| Chungnam National University Hospital Daejeon, | |
| Chungnam National University Hospital Daejeon, | |
| Chungnam National University Sejong Hospital Sejong-si, | |
| Cleveland Clinic_Cleveland Cleveland, Ohio | |
| Clínica Privada Velez Sarsfield Córdoba, | |
| Clínica Privada Velez Sarsfield Córdoba, | |
| Colorado Heart and Vascular PC Golden, Colorado | |
| Complejo Hospitalario Universitario A Coruna A Coruña, | |
| Complejo Hospitalario Universitario A Coruna A Coruña, | |
| Concord Repatriation General Hospital - Cardiology Department Concord, New South Wales | |
| Copernicus Podmiot Leczniczy Sp. z o.o. Gdansk, | |
| Corewell Health Grand Rapids, Michigan | |
| Dallas VA Medical Center Dallas, Texas | |
| Danbury Hospital - Cardiology Department Danbury, Connecticut | |
| Dartmouth-Hitchcock Med Ctr Lebanon, New Hampshire | |
| Dayanand Medical College & Hospital Ludhiana, Punjab | |
| Dayanand Medical College & Hospital Ludhiana, Punjab | |
| Deenanath Mangeshkar Hospital & Research Centre Pune, | |
| Deenanath Mangeshkar Hospital & Research Centre Pune, | |
| Denver Health Medical Center Denver, Colorado | |
| Derriford Hospital - Plymouth Plymouth, | |
| Deutsches Herzzentrum TU München - Klinik für Herz- und Kreislauferkrankungen München, | |
| Dolnoslaski Szpital Specjalistyczny Im. T.Marciniaka-Centrum Medycyny Ratunkowej Wroclaw, | |
| Dr. Ram Manohar Lohia Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Dr. Ram Manohar Lohia Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji Istanbul, | |
| Duke University Medical Center Durham, North Carolina | |
| ESIC Medical College and Hospital, Hyderabad Hyderabad, Telangana | |
| Eastern Shore Rsrch Inst, LLC Fairhope, Alabama | |
| Ehime Prefectural Central Hosp Ehime, | |
| Elisabeth-TweeSteden Ziekenhuis Tilburg, | |
| Emory University Hospital Atlanta, Georgia | |
| Endeavor Health Glenbook Hosp Evanston, Illinois | |
| Ente Ecclesiastico Ospedale Generale Regionale Miulli - Cardiologia e UTIC Acquaviva delle Fonti, | |
| Erciyes University Cardiology Kayseri, | |
| Erciyes Üniversitesi Hastanesi- Kardiyoloji Kayseri, | |
| Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji Eskişehir, | |
| Eskişehir Şehir Hastanesi- Kardiyoloji Eskişehir, | |
| Essentia Health Duluth, Minnesota | |
| Evangelismos Hospital Athens, | |
| Ewha Womans University Seoul Hospital Seoul, | |
| FN u Sv. Anny Brno, | |
| FN u Sv. Anny Brno, | |
| Fairview Health Services Maplewood, Minnesota | |
| Fairview Health Services Maplewood, Minnesota | |
| Fakultni nemocnice Brno Brno, | |
| Fakultni nemocnice Kralovske Vinohrady Prague, Prague | |
| Fakultni nemocnice Olomouc Olomouc, | |
| Fakultni nemocnice Plzen - Lochotin Plzen - Lochotín, | |
| Flinders Medical Centre Adelaide, South Australia | |
| Fondazione IRCCS Policlinico San Matteo Pavia, | |
| Fondazione IRCCS San Gerardo dei Tintori Monza, | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCS Roma, | |
| Fondazione Policlinico Universitario Agostino Gemelli Irccs Roma, | |
| Fortis Escorts Heart Institute, New Delhi New Delhi, National Capital Territory of Delhi | |
| Fortis Hospital, Mohali Mohali, Punjab | |
| Fortis Hospital, Mohali Mohali, Punjab | |
| Freeman Hospital, Newcastle Newcastle upon Tyne, | |
| Fujita Health University Hospital_Cardiology Aichi, | |
| Fujita Health University Hospital_Cardiology Aichi, | |
| Fukuoka University Hospital_Cardiology Fukuoka-shi, Fukuoka, | |
| Fukuoka University Hospital_Cardiology Fukuoka-shi, Fukuoka, | |
| Fundacion Favaloro CABA, | |
| Fundación Nuestra Señora del Rosario - Estudios Clínicos los Arroyos San Nicolás de los Arroyos, Buenos Aires | |
| G B Pant Institute of Postgraduate Medical Education and Research New Delhi, National Capital Territory of Delhi | |
| G. Kuppuswamy Naidu Memorial Hospital Coimbatore, Tamil Nadu | |
| G. Kuppuswamy Naidu Memorial Hospital Coimbatore, Tamil Nadu | |
| G.H. of Athens "Evaggelismos" Athens, | |
| Gachon University Gil Medical Center Incheon, Namdong-gu | |
| Ganesh Shankar Vidyarthe Memorial (GSVM) Medical College Kanpur, Uttar Pradesh | |
| Geisinger Medical Center Danville, Pennsylvania | |
| Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt Thessaloniki, | |
| General Hospital Of Eleusina Thriasio - Cardiology Clinic Eleusina, | |
| General Hospital Of Patras Agios Andreas - Cardiology Department Pátrai, | |
| General Hospital of Athens "Elpis" - Cardiology Department Ampelokipoi/Athens, | |
| General Hospital of Athens "Laiko" Goudi/Athens, | |
| General Hospital of Chios "Skilitsio" - Cardiology Clinic Chios, | |
| General Hospital of Imathia Monada Veria Véroia, | |
| General Hospital of Imathia Monada Veria - Cardiology Department Véroia, | |
| General Hospital of Thessaloniki PAPAGEORGIOU Nea Efkarpia, Thessaloniki | |
| General Hospital of Tianjin Medical University-Endocrinology Tianjin, Tianjin Municipality | |
| Genesis Health Care System Zanesville, Ohio | |
| Geniko Nosokomeio Peiraia Tzaneio - Cardiology department Piraeus, | |
| Glenfield Hospital Leicester, | |
| Gold Coast University Hospital - Cardiology Department Southport, Queensland | |
| Gold Coast University Hosptial Southport, Queensland | |
| Golden Jubilee University National Hospital Glasgow, | |
| Grande Ospedale Metropolitano Niguarda Milan, | |
| Grandview Medical Center Birmingham, Alabama | |
| Grey Nuns Community Hospital Edmonton, Alberta | |
| Groene Hart Zkh Gouda - Cardiologie Gouda, | |
| Group Euroclinic - Athens Euroclinic - Cardiology Department Athens, | |
| Guangdong Provincial People's Hospital Guangzhou, | |
| Guangdong Provincial People's Hospital Guangzhou, | |
| H. Clinico Univ. Virgen de la Victoria, Malaga Málaga, | |
| HCA Research Institute McAllen, Texas | |
| HMC, locatie Westeinde - Cardiologie The Hague, | |
| Hackensack Meridian Health Hackensack, New Jersey | |
| Hadassah Ein Karam MC - Cardio Department Jerusalem, | |
| Hadassah Mount Scorpus MC - Cardiology department Jerusalem, | |
| Hamilton Health Sciences Corp, Ontario Hamilton, Ontario | |
| Hanaoka Seishu Memorial Hosp._Cardiovascular Medicine Hokkaido, | |
| Hanaoka Seishu Memorial Hospital Hokkaido, | |
| Hanyang University Seoul Hospital Seoul, | |
| Harefield Hospital Harefield, Middlesex | |
| Health Sciences North Rsrch Inst Greater Sudbury, Ontario | |
| Heart & Vascular Inst._Titus Mount Pleasant, Texas | |
| Heart Center Rsrch_Hunstville Huntsville, Alabama | |
| Hebei General Hospital Shijiazhuang, Hebei | |
| Helios Klinikum Erfurt GmbH - 3. Med. Klinik - Kardiologie Erfurt, | |
| Henry Dunant Hospital Center Athens, | |
| Heritage Medical Research Clinic Calgary, | |
| Herlev og Gentofte Hospital Hellerup, Capital Region | |
| Hermosillo Heart Team Hermosillo, Sonora | |
| Hillel Yaffe MC - Cardiology Department Hadera, | |
| Hippokration Hospital Athens, | |
| Holy Cross Hospital Fort Lauderdale, Florida | |
| Holy Name Medical Center Teaneck, New Jersey | |
| Honor Health Phoenix, Arizona | |
| Hopital Sacre-Coeur de Montreal Montreal, Quebec | |
| Hospices Civils de Lyon- Hopital Louis Pradel Bron, | |
| Hospital Agamenon Magalhães Recife, Pernambuco | |
| Hospital Agamenon Magalhães Recife, Pernambuco | |
| Hospital Alvaro Cunqueiro de Vigo Vigo, | |
| Hospital Angeles de Culiacan Culiacán, Sinaloa | |
| Hospital Angeles de Xalapa Xalapa, Veracruz | |
| Hospital Angeles de las Lomas México, State of Mexico | |
| Hospital Canselor Tuanku Muhriz UKM Cheras, Kuala Lumpur | |
| Hospital Cardiologica Aguascalientes Aguascalientes, Aguascalientes | |
| Hospital Civil De Guadalajara Fray Antonio Alcalde Guadalajara, Jalisco | |
| Hospital Clinic i Provincial Barcelona, | |
| Hospital Clinico San Carlos Madrid, | |
| Hospital Clinico Universitario de Valencia Valencia, | |
| Hospital Clinico Universitario de Valladolid Valladolid, | |
| Hospital Clinico de Santiago Santiago de Compostela, | |
| Hospital Clinico de Santiago Santiago de Compostela, | |
| Hospital De La Santa Creu I Sant Pau Barcelona, | |
| Hospital De La Santa Creu I Sant Pau Barcelona, | |
| Hospital Del Mar Barcelona, | |
| Hospital Del Mar Barcelona, | |
| Hospital Dr. Jose Maria Cullen Santa Fe, | |
| Hospital Espanol De Mendoza Godoy Cruz, Mendoza, Mendoza Province | |
| Hospital Espanol De Mendoza Godoy Cruz, Mendoza, Mendoza Province | |
| Hospital General Universitario Dr. Balmis Alicante, | |
| Hospital General de Mexico (HGM) Cuauhtémoc, Mexico City | |
| Hospital Germans Trias I Pujol Barcelona, | |
| Hospital Germans Trias I Pujol Barcelona, | |
| Hospital Gral Alicante Dr. Balmis Alicante, | |
| Hospital Gregorio Maranon Madrid, | |
| Hospital Gregorio Maranon Madrid, | |
| Hospital Israelita Albert Einstein Morumbi, São Paulo | |
| Hospital Italiano Buenos Aires, | |
| Hospital Italiano de la Plata La Plata, Buenos Aires | |
| Hospital Juárez de Mexico Ciudad de México, D.F., | |
| Hospital Juárez de Mexico Ciudad de México, D.F., | |
| Hospital Maternidade e Pronto Socorro Santa Lucia Poços de Caldas, Minas Gerais | |
| Hospital Mãe de Deus - Porto Alegre Porto Alegre/RS, | |
| Hospital Pulau Pinang George Town, | |
| Hospital Queen Elizabeth II Kota Kinabalu, | |
| Hospital Raja Perempuan Zainab II Kelantan, | |
| Hospital Raja Permaisuri Bainun Ipoh Ipoh, Perak | |
| Hospital Ramon Y Cajal Madrid, | |
| Hospital Ruy Azeredo Ltda Goiânia, Goiás | |
| Hospital Serdang Kajang, Selangor | |
| Hospital Serdang Kajang, Selangor | |
| Hospital Sultanah Aminah Johor Bahru, Johor | |
| Hospital Sultanah Bahiyah Alor Star, Kedah | |
| Hospital São Lucas - PUC/RS Porto Alegre, Rio Grande do Sul | |
| Hospital Tengku Ampuan Afzan Kuantan, Pahang | |
| Hospital Univ. Virgen de la Arrixaca El Palmar, | |
| Hospital Universitari Joan XXIII Tarragona, | |
| Hospital Universitari Joan XXIII Tarragona, | |
| Hospital Universitario Austral Pilar, | |
| Hospital Universitario Austral - Instituto de Cardiologia Pilar, Buenos Aires | |
| Hospital Universitario Dr. Jose Eleuterio Gonzalez Monterrey, | |
| Hospital Universitario La Paz Madrid, | |
| Hospital Universitario Marqués de Valdecilla Santander, | |
| Hospital Universitario Virgen del Rocio Seville, | |
| Hospital Universitario de La Princesa Madrid, | |
| Hospital Universiti Kebangsaan Malaysia Cheras, Kuala Lumpur | |
| Hospital Universiti Sains Malaysia_Kota Bharu, Kelantan Kota Bharu, Kelantan, | |
| Hospital Virgen de la Arrixaca El Palmar, Murcia | |
| Hospital das Clínicas da Universidade Federal do Triangulo Mineiro Uberaba, Minas Gerais | |
| Hospital de Lleida "Arnau de Vilanova" Lleida, | |
| Hospital del Centenario Rosario, Santa Fe, Santa Fe Province | |
| Hospital do Coração do Brasil Brasília, Federal District | |
| Houston Medical Center Houston, Texas | |
| Houston Medical Center Houston, Texas | |
| Houston Methodist Hospital Houston, Texas | |
| Huashan Hospital Fudan University Shanghai, Shanghai Municipality | |
| Huashan Hospital Fudan University Shanghai, Shanghai Municipality | |
| Hyogo Medical University Hospital_Cardiovascular Medicine Hyōgo, | |
| Hyogo Medical University Hospital_Cardiovascular Medicine Hyōgo, | |
| Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology Himeji-shi, Hyogo, | |
| Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology Himeji-shi, Hyogo, | |
| ICOT Istituto Marco Pasquali - UOC Cardiologia Latina, Lazio | |
| ICOT Istituto Marco Pasquali - UOC Cardiologia Latina, Lazio | |
| II. interni klinika VFN - Kardiologie a angiologie Prague, | |
| IKEM Prague, | |
| IRCCS Policlinico San Donato San Donato Milanese, MI | |
| Ikazia Ziekenhuis Rotterdam, | |
| Illawarra Heart Health Centre Wollongong, New South Wales | |
| Indiana University Health Methodist Hospital Indianapolis, Indiana | |
| Indraprastha Apollo Hospital, New Delhi New Delhi, National Capital Territory of Delhi | |
| Indraprastha Apollo Hospital, New Delhi New Delhi, National Capital Territory of Delhi | |
| Inha University Hospital Incheon, | |
| Inje University Haeundae Paik Hospital Busan, | |
| Inova Fairfax Medical Campus, Falls Church Fairfax, Virginia | |
| Ins Uni de Cardi et de PNA de Québec, | |
| Inspira Health - Cardiology Mullica Hill, New Jersey | |
| Instituto Cardiovascular Buenos Aires CABA, Buenos Aires | |
| Instituto Dante Pazzanese de Cardiologia São Paulo, São Paulo | |
| Instituto Nacional de Cardiologia Ignacio Chavez Mexico City, | |
| Instituto Nacional de Ciencias Medicas y Nutricion Tlalpan, Mexico City | |
| Instituto Nacional de Ciencias Medicas y Nutricion Tlalpan, Mexico City | |
| Instituto de Cardiología de Corrientes Corrientes, | |
| Instituto de Pesquisa Clinica de Campinas Campinas, | |
| Integral Pesquisa e Ensino Votuporanga, São Paulo | |
| Integral Pesquisa e Ensino Votuporanga, São Paulo | |
| Interbalkan Medical Center of Thessaloniki Thessaloniki, | |
| Intercard Spolka z ograniczona odpowiedzialnoscia Krosno, | |
| Intercard Spolka z ograniczona odpowiedzialnoscia Krosno, | |
| Intercoastal Medical Group Sarasota, Florida | |
| Intercoastal Medical Group Sarasota, Florida | |
| Intermountain Medical Center Murray, Utah | |
| Interventional Cardiology Medical Group West Hills, California | |
| Irmandade Santa Casa de Misericórdia de Passos Passos, Minas Gerais | |
| Irmandade da Santa Casa de Misericordia de Porto Alegre Porto Alegre, Rio Grande do Sul | |
| Irmandade da Santa Casa de Misericórdia de Marília Marília, São Paulo | |
| Ishikawa Prefectural Central Hospital_Cardiology Ishikawa, | |
| Ishikawa Prefectural Central Hospital_Cardiology Ishikawa, | |
| Ishikiriseiki Hospital_Circulatory Medicine Osaka, | |
| Istanbul University Cerrahpasa Medical Faculty Istanbul, Bakirkoy | |
| Jackson Heart Clinic Jackson, Mississippi | |
| Jacobi Medical Center The Bronx, New York | |
| Jacobi Medical Center The Bronx, New York | |
| Jadestone Clinical Research, LLC Silver Spring, Maryland | |
| Japanese Red Cross Fukuoka Hospital_Cardiology Fukuoka, | |
| Japanese Red Cross Fukuoka Hospital_Cardiology Fukuoka, | |
| Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry, Tamil Nadu | |
| Jawaharlal Nehru Medical College and Hospital Aligarh, Uttar Pradesh | |
| Jawaharlal Nehru Medical College and Hospital Aligarh, Uttar Pradesh | |
| Jeroen Bosch Zkh 's-Hertogenbosch, | |
| Jersey City Med Center Jersey City, New Jersey | |
| Jinan Central Hospital Jinan, | |
| Jmf Clínica Do Coração Ltda Aracaju, | |
| Juntendo University Shizuoka Hospital Izunokuni, | |
| Juntendo University Shizuoka Hospital_Gastroenterology & Hepatology Izunokuni-shi, Shizuoka, | |
| Justice K S Hegde Charitable Hospital Mangaluru, Karnataka | |
| Kagawa Prefectural Central Hospital_Cardiovascular Medicine Takamatsu-shi, Kagawa, | |
| Kaiser Permanente Viewridge Medical Offices San Diego, California | |
| Kanto Rosai Hospital_Cardiology Kanagawa, | |
| Kanto Rosai Hospital_Cardiology Kanagawa, | |
| Kaplan MC - Cardiac Intensive Care Rehovot, | |
| Kartal Kosuyolu Yuksek Ihtisas EAH Istanbul, | |
| Kasturba Medical College and Hospital, Manipal Udupi, Karnataka | |
| Kat Attica General Hospital - Cardiology Department Kifissia, | |
| Kath. St. Paulus GmbH - St Johannes Hospital Dortmund - Kardiologie Dortmund, | |
| Kayseri City Hospital Kayseri, | |
| Kayseri Şehir Hastanesi-Kardiyoloji Kayseri, | |
| Keimyung University Dongsan Hospital Daegu, | |
| Kelowna Cardiology Res. Ltd. Kelowna, British Columbia | |
| Kettering General Hospital Kettering, | |
| Kettering Medical Center Kettering, Ohio | |
| King George Hospital Visakhapatnam, Andhra Pradesh | |
| King George's Medical University (KGMU) Lucknow, Uttar Pradesh | |
| King George's Medical University (KGMU) Lucknow, Uttar Pradesh | |
| King's College Hospital - Cardiology London, | |
| Kings College Hospital London, | |
| Kingston General Hospital Kingston, Ontario | |
| Kingston General Hospital Kingston, Ontario | |
| Kliniczny Szpital Wojewodzki nr 2 im. Sw. Jadwigi Krolowej w Rzeszowie Rzeszów, | |
| Klinikum Friedrichshafen GmbH - Klinik für Kardiologie, Angiologie, Pneumologie und internistische Intensivmedizin Friedrichshafen, | |
| Klinikum Fulda gAG - Med. Klinik I Fulda, | |
| Klinikum Leverkusen gGmbH - Med. Klinik 1 Leverkusen, | |
| Knoxville Heart Group Knoxville, Tennessee | |
| Kocaeli Üniversitesi Hastanesi- Kardiyoloji Kocaeli, | |
| Konstantopouleio G.H. of Athens, "Agia Olga" Athens, | |
| Korea University Anam Hospital Seoul, | |
| Korea University Guro Hospital Seoul, Guro-gu | |
| Koşuyolu Yüksek İhtisas EAH- Kardiyoloji Istanbul, | |
| Krajska zdravotni, a.s. - Masarykova nemocnice v Usti nad Labem, o.z. Ústní Nad Labem, Czechia | |
| Krajská nemocice Liberec, a.s Liberec, | |
| Krajská nemocnice T.Bati a.s. Zlín, | |
| Kyung Hee University Hospital at Gangdong Seoul, | |
| Kyunghee University Medical Center Seoul, | |
| Kyungpook National University Hospital Junggu, | |
| Kütahya Sağlık Bilimleri Üniversitesi Evliya Çelebi EAH- Kardiyoloji Merkez/Kütahya, | |
| Kütahya Şehir Hastanesi-Kardiyoloji Kütahya, | |
| LA BioMed Harbor UCLA Med Cenr Torrance, California | |
| Lakshmi Hospital Palakkad, | |
| Lalitha PVS Institute of Medical Sciences Guntur, Andhra Pradesh | |
| Les Hopitaux de Chartres-Hopital Louis Pasteur Le Coudray, | |
| Lincoln County Hospital Lincoln, | |
| Lincoln County Hospital Lincoln, | |
| Lindner Center,Christ Hospital Cincinnati, Ohio | |
| Lisie Hospital Kochi, | |
| Lister Hospital Stevenage, | |
| Lister Hospital Stevenage, | |
| Liver Ins@ Mthdist DTX Med Cen Dallas, Texas | |
| Liverpool Heart & Chest Hospital Liverpool, | |
| Liverpool Hospital Sydney, | |
| Liverpool Hospital Sydney, | |
| Loma Linda University Faculty Medical Clinics Loma Linda, California | |
| London Health Sciences Center Ontario London, Ontario | |
| Louis Stokes Clvlnd VA Med Ctr Cleveland, Ohio | |
| Lyell McEwin Hospital Elizabeth Vale, South Australia | |
| Lyell McEwin Hospital Elizabeth Vale, South Australia | |
| MHAT "Dr. Bratan Shukerov" Smolyan, | |
| MHAT - Cardiolife OOD - Lovech Lovech, | |
| MHAT - City Clinic - Sveti Georgi EOOD Montana, | |
| MHAT - Dr. Atanas Dafovski AD, Cardiology department Kardzhali, | |
| MHAT - Ivan Skenderov EOOD Gotse Delchev, | |
| MHAT - Pazardzhik AD Pazardzhik, | |
| MHAT Dr. Bratan Shukerov Smolyan, | |
| MHAT Dr. Tota Venkova AD Gabrovo, | |
| MHAT Hadzhi Dimitar OOD Sliven, | |
| MHAT Haskovo AD Haskovo, | |
| MHAT Heart and Brain EAD - Burgas, Cardiology Burgas, | |
| MHAT Heart and Brain EAD - Pleven, Cardiology Pleven, | |
| MHAT MC-Sv Ivan Rilski EOOD Plovdiv, | |
| MHAT National Cardiology Hospital EAD Sofia, | |
| MHAT Puls AD, Cardiology Department Blagoevgrad, | |
| MHAT Southwest Hospital OOD, Cardiology Department Sandanski, | |
| MHAT Sveta Karidad EAD Plovdiv, | |
| MVZ CCB Frankfurt Und Main-Taunus GbR Frankfurt, | |
| Maasstad Ziekenhuis - Cardiologie Rotterdam, | |
| Maine Medical Center Bramhall Scarborough, Maine | |
| Malla Reddy Narayana Multispeciality Hospital Hyderabad, Telangana | |
| Malla Reddy Narayana Multispeciality Hospital Hyderabad, Telangana | |
| Marengo CIMS Hospital Ahmedabad, Gujarat | |
| Marmara University Medical Faculty Istanbul, | |
| Marmara Üniversitesi Pendik EAH- Kardiyoloji Istanbul, | |
| Matsuyama Red Cross Hospital_Department of Cardiovascular Medicine Ehime, | |
| Max Super Speciality Hospital, Saket New Delhi, National Capital Territory of Delhi | |
| Mayo Clinic Arizona Phoenix, Arizona | |
| Mayo Clinic Jacksonville Jacksonville, Florida | |
| McGuire VA Medical Center Richmond, Virginia | |
| McLaren Bay Region Bay City, Michigan | |
| McLaren Greater Lansing Lansing, Michigan | |
| McLaren Macomb Health Care Mount Clemens, Michigan | |
| McLaren Northern MI Hosp Petoskey, Michigan | |
| Meander MC Amersfoort, | |
| MedStar Hlth Res Institute Clinton, Maryland | |
| MedStar Hlth Res Institute Clinton, Maryland | |
| Medical College & Hospital, Kolkata Kolkata, West Bengal | |
| Medical College & Hospital, Kolkata Kolkata, West Bengal | |
| Medicover Hospitals, Visakhapatnam MVP Visakhapatnam, Andhra Pradesh | |
| Medisch Spectrum Twente - Cardiologie Enschede, | |
| Medizinische Hochschule Hannover - Kardiologie und Angiologie Hanover, | |
| Meir MC - Cardiology department Kfar Saba, | |
| Memorial Healthcare Owosso, Michigan | |
| Mercy Gilbert Medical Center Gilbert, Arizona | |
| Mercy Health - St. Vincent Medical Center Toledo, Ohio | |
| Mercy Research Springfield, Missouri | |
| MercyOne NE Iowa Fam Med & Res Waterloo, Iowa | |
| Mersin Üniversitesi Hastanesi- Kardiyoloji Mersin, | |
| Mersin Şehir Eğitim Araştırma Hastanesi- Kardiyoloji Mersin, | |
| Methodist Healthcare System of San Antonio San Antonio, Texas | |
| Methodist Healthcare System of San Antonio San Antonio, Texas | |
| Methodist Physicians Clinic Omaha, Nebraska | |
| MetroHealth Medical Center Cleveland, Ohio | |
| Metropolitan General Hospital Healthcare Facilities Operation And Management Single Member S.A. - Cardiology Clinic Athens, | |
| MidMic Medical Cntr - Midland Midland, Michigan | |
| Midwest Cardiovascu Rsrch Foundation Davenport, Iowa | |
| Midwest Heart and Vascular Specialists Overland Park, Kansas | |
| Midwest Heart and Vascular Specialists Overland Park, Kansas | |
| Miedziowe Centrum Zdrowia s.a. Lubin, | |
| Missouri Cardiovascular Specialist Columbia, Missouri | |
| Mito Saiseikai General Hospital_Cardiology Ibaraki, | |
| Mito Saiseikai General Hospital_Cardiology Ibaraki, | |
| Miyazaki Medical Association Hospital Miyazaki, Miyazaki | |
| Miyazaki Medical Association Hospital_Cardiology Miyazaki, Miyazaki | |
| Mobile Heart USA Health Cardiology Clinic Mobile, Alabama | |
| Monument Health Clinical Rsrch Rapid City, South Dakota | |
| Morriston Hospital Swansea, | |
| Moses H. Cone Mem Hosp Greensboro, North Carolina | |
| Mount Sinai Morningside New York, New York | |
| Multicare Health System Tacoma, Washington | |
| Multiprofile Hospital For Active Treatment Dr. Tota Venkova AD Gabrovo, | |
| Musgrove Park Hospital Taunton, Somerset | |
| Myongji Hospital Goyang-si, Gyeonggi-do | |
| NC Heart and Vascular Research Raleigh, North Carolina | |
| NHO Kure Medical Center and Chugoku Cancer Center Kure-shi, Hiroshima, | |
| NHO Kure Medical Center and Chugoku Cancer Center_Cardiology Kure-shi, Hiroshima, | |
| NIMTS Army Share Fund Hospital Athens, | |
| NUPEC Cardio Belo Horizonte, Minas Gerais | |
| NYU Grossman School of Med New York, New York | |
| Nanfang Hospital, Southern Medical University Guangzhou, Guangdong | |
| Nanfang Hospital, Southern Medical University Guangzhou, Guangdong | |
| Nanjing Drum Tower Hospital Nanjing, | |
| Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy Warsaw, | |
| National Heart Institute Kuala Lumpur, | |
| National Heart Institute Kuala Lumpur, | |
| National Hospital Organization Kumamoto Medical Center_Cardiology Kumamoto, | |
| National Hospital Organization Kumamoto Medical Center_Cardiology Kumamoto, | |
| Necmettin Erbakan University Hospital Konya, | |
| Necmettin Erbakan Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji Konya, | |
| Nemocnice AGEL Třinec-Podlesí a.s. Třinec, | |
| Nemocnice Na Homolce Prague, | |
| Nemocnice Pardubickeho kraje a.s. Pardubice, | |
| Nemocnice České Budějovice a.s. České Budějovice, | |
| Nepean Hospital Kingswood, New South Wales | |
| New Brunswick Heart Centre Saint John, New Brunswick | |
| New Brunswick Heart Centre Saint John, New Brunswick | |
| New Cross Hospital Wolverhampton, West Midlands | |
| Niagara Health System St. Catharines, Ontario | |
| Nil Ratan Sircar Medical College and Hospital Kolkata, West | |
| Nil Ratan Sircar Medical College and Hospital Kolkata, West | |
| Nishinomiya Watanabe Cardiovascular Cerebral Center_Cardiovascular Medicine Hyōgo, | |
| Noordwest Ziekenhuisgroep Alkmaar, | |
| Nordsjællands hospital - Kardiologisk Forskning Hillerød, | |
| North Kansas City Hospital Kansas City, Missouri | |
| North Mississippi Medical Center Tupelo, Mississippi | |
| Northeast Georgia Medical Ctr Gainesville, Georgia | |
| Northern General Hospital Sheffield, | |
| Northern General Hospital Sheffield, | |
| Northern Health Epping, Victoria | |
| Northern Light Eastern Maine Medical Center Bangor, Maine | |
| Novant Hlth Cardio - Kimel Park Winston-Salem, North Carolina | |
| Novant Hlth Vasc Ins Charlotte Charlotte, North Carolina | |
| Nuevo Hospital Civil "Dr. Juan I. Menchaca" Guadalajara, Jalisco | |
| Nuevo Hospital Civil "Dr. Juan I. Menchaca" Guadalajara, Jalisco | |
| OLVG Oost Amsterdam, | |
| OSF HealthCare_Cardiovasc Inst Peoria, Illinois | |
| Odense Universitetshospital, Kardiologisk afd. Odense C, | |
| Odense Universitetshospital, Kardiologisk afd. Odense C, | |
| Ondokuz Mayıs Üniversitesi Hastanesi- Kardiyoloji Samsun, | |
| Osaka General Medical Center_Cardiology Osaka, | |
| Osmania General Hospital Hyderabad, Telangana | |
| Osmania General Hospital Hyderabad, Telangana | |
| Ospedale Civile dell'Annunziata Cosenza, | |
| Ospedale Isola Tiberina Gemelli Isola Rome, | |
| Ospedale Maggiore Carlo Alberto Pizzardi Bologna, | |
| Ospedale Policlinico San Martino Genoa, Liguria | |
| Ospedale Sandro Pertini - UOC Cardiologia Rome, | |
| Ospedale Sant'Andrea - UOC Cardiologia La Spezia, | |
| Overton Brooks V.A. Medical Center Shreveport, Louisiana | |
| Overton Brooks V.A. Medical Center Shreveport, Louisiana | |
| PUCCAMP - Hospital e Maternidade Celso Pierro Campinas, São Paulo | |
| PUCCAMP - Hospital e Maternidade Celso Pierro Campinas, São Paulo | |
| Pan-Arcadian General Hospital of Tripoli Evangelistria - Cardiology Department Tripoli, | |
| Parkway Cardiology Associates, PC Oak Ridge, Tennessee | |
| Peking University First Hospital-Cardiology Beijing, Beijing Municipality | |
| Peking University First Hospital-Cardiology Beijing, Beijing Municipality | |
| Peking University Third Hospital Beijing, Beijing Municipality | |
| Peking University Third Hospital Beijing, Beijing Municipality | |
| Peninsula University Hospital - Cardiology Department Frankston, Victoria | |
| Penn State Hershey Medical Center Hershey, Pennsylvania | |
| Penn State Hlth Holy Spirit Med Ctr Camp Hill, Pennsylvania | |
| PharmaTex Research, LLC Amarillo, Texas | |
| Podhalanski Szpital Specjalistyczny Nowy Targ, | |
| Policlinico Casilino - Cardiologia e UTIC Rome, | |
| Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh Chandigarh, | |
| Prairie Cardiovascular Consultants, Ltd. Springfield, Illinois | |
| Presidio Ospedaliero di Rivoli Rivoli, To | |
| Prince of Wales Hospital - Sydney Randwick, New South Wales | |
| Princess Alexandra Hospital Woolloongabba, Queensland | |
| Princess Alexandra Hospital Woolloongabba, Queensland | |
| Prism Hlth Carolina Card Cons Greenville, South Carolina | |
| ProMedica Toledo, Ohio | |
| Prolato Clinical Research Cntr Houston, Texas | |
| Pusan National University Yangsan Hospital Yangsan, | |
| Pusan National University Yangsan Hospital Yangsan, | |
| QE II Health Sciences Centre Halifax, Nova Scotia | |
| QE II Health Sciences Centre Halifax, Nova Scotia | |
| Queen Alexandra Hospital Portsmouth, | |
| Queen Alexandra Hospital - Cardiology Portsmouth, | |
| Rabin MC -Beilinson - Cardiac intensive unit Petah Tikva, | |
| Radboudumc Nijmegen, Gelderland | |
| Ramaiah Memorial Hospital Bengaluru, Karnataka | |
| Rambam MC - Cardiac Intensive Care Unit Haifa, | |
| Reading Hospital West Reading, Pennsylvania | |
| Regina General Hospital Regina, Saskatchewan | |
| Regions Hospital Saint Paul, Minnesota | |
| Reid Physician Associates Richmond, Indiana | |
| Renmin Hospital of Wuhan University-Cardiology Wuhan, Hubei | |
| Rhode Island Hospital Providence, Rhode Island | |
| Rhythm Heart Institute Vadodara, Gujarat | |
| Rhön-Klinikum AG - Zentralklinik Bad Berka - Kardiologie Bad Berka, | |
| Rigshospitalet - Kardiologisk Forskningsenhed København Ø, | |
| Rijnstate Ziekenhuis Arnhem, | |
| Robert Packer Hospital Sayre, Pennsylvania | |
| Robert-Bosch-Krankenhaus GmbH Stuttgart Stuttgart, | |
| Royal Adelaide Hospital - Cardiology Department Adelaide, South Australia | |
| Royal Adelaide Hospital Cardiovascular Clinical Trials Adelaide, South Australia | |
| Royal Alexandra Hospital Edmonton, Alberta | |
| Royal Bournemouth Hospital - Cardiology Bournemouth, Dorset | |
| Royal Brisbane and Women's Hospital Herston, Queensland | |
| Royal Brompton and Harefield Hospitals Harefield, Middlesex | |
| Royal Cornwall Hospital (Treliske) Truro, Cornwall | |
| Royal Infirmary of Edinburgh - Cardiology Edinburgh, | |
| Royal Perth Hospital Perth, Western Australia | |
| Royal University Hospital Saskatoon, Saskatchewan | |
| Royal Victoria Regional Health Centre Barrie, Ontario | |
| Royal Victoria Regional Health Centre Barrie, Ontario | |
| S Denver Cardiology Associates Littleton, Colorado | |
| S.P. Medical College & Associated Group of Hospitals Bikaner, | |
| S.P. Medical College & Associated Group of Hospitals Bikaner, | |
| SCANMED Spółka Akcyjna Kluczbork, | |
| SCANMED Spółka Akcyjna Kluczbork, | |
| SCANMED Spółka Akcyjna Kluczbork, | |
| SCANMED Spółka Akcyjna Kluczbork, | |
| SCANMED Spółka Akcyjna Kluczbork, | |
| SCANMED Spółka Akcyjna Kluczbork, | |
| SCB Medical College and Hospital Cuttack, Odisha | |
| SHATC - Cardiolife OOD - Varna Varna, | |
| SHATC - Medica Kor EAD Rousse, | |
| SHATC - Yambol EAD Yambol, | |
| SMC Heart Institute and IVF Research Centre Raipur, Chhattisgarh | |
| SMS Medical College & Attached Hospitals Jaipur, Rajasthan | |
| SMS Medical College & Attached Hospitals Jaipur, Rajasthan | |
| Sahyadri Super Speciality Hospital Pune, | |
| Saint Elizabeth Medical Center Edgewood, Kentucky | |
| Saint Joseph's Hospital Health Center Liverpool, New York | |
| Saint Paul's Hospital Vancouver, British Columbia | |
| Saint Thomas Hospital Nashville, Tennessee | |
| Saiseikai Yokohamashi Nanbu Hospital_Cardiology Yokohama-shi, Kanagawa, | |
| Saiseikai Yokohamashi Nanbu Hospital_Cardiology Yokohama-shi, Kanagawa, | |
| Saiseikai Yokohamashi Tobu Hospital_Cardiology Kanagawa, | |
| Saiseikai Yokohamashi Tobu Hospital_Cardiology Kanagawa, | |
| Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II Grodzisk Mazowiecki, | |
| Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II Grodzisk Mazowiecki, | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie Rzeszów, | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie Krakow, | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Pulawach Puławy, Lublin Voivodeship | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Pulawach Puławy, Lublin Voivodeship | |
| Samodzielny Publiczny Zespol Opieki Zdrowotnej w Swidnicy Swidnica, | |
| Samodzielny Publiczny Zespol Opieki Zdrowotnej w Swidnicy Swidnica, | |
| Samodzielny Publiczny Zespół Zakładów Opieki Zdrowotnej w Ostrowi Mazowieckiej Ostrów Mazowiecka, | |
| San Diego Cardiac Center San Diego, California | |
| San Francisco V.A. Medical Center San Francisco, California | |
| San Francisco V.A. Medical Center San Francisco, California | |
| Sanatorio Finochietto Buenos Aires, | |
| Sanatorio Finochietto Buenos Aires, | |
| Sanatorio Güemes Ciudad de Buenos Aires, Buenos Aires | |
| Sanatorio Modelo Quilmes Quilmes, Buenos Aires | |
| Sanatorio Parque Rosario, Santa Fe Province | |
| Sanford Health - Fargo Fargo, North Dakota | |
| Sanford Health - Fargo Fargo, North Dakota | |
| Sanford Research Sioux Falls, South Dakota | |
| Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Sarawak Heart Centre Kota Samarahan, Sarawak | |
| Sardar Vallabhbhai Patel Institute of Medical Sciences and Research Ahmedabad, Gujarat | |
| Sentara Bayside Hospital Norfolk, Virginia | |
| Seoul National University Bundang Hospital Seongnam, Kyeonggi-do | |
| Seoul National University Hospital Seoul, Seoul Teugbyeolsi | |
| Servicios Integrales Nova de Monterrey San Nicolás de los Garza, | |
| Servicios Integrales Nova de Monterrey San Nicolás de los Garza, | |
| Seth GS Medical College & KEM Hospital Mumbai, Maharashtra | |
| Seth GS Medical College & KEM Hospital Mumbai, Maharashtra | |
| Severance Hospital, Yonsei University Health System Seoul, | |
| Shamir MC - Cardiology Department Beer Yaakov, | |
| Sheba MC - Cardiology Clinical Research Unit Tel Litwinsky, | |
| Shengjing Hospital of China Medical University Shenyang, | |
| Shengjing Hospital of China Medical University-Cardiology Shenyang, Liaoning | |
| Shiga University of Medical Science Hospital_Cardiology Shiga, | |
| Shri B. D. Mehta Mahavir Heart Institute Surat, Gujarat | |
| Shri Krishna Hrudayalaya & Critical Care Centre Nagpur, Maharashtra | |
| Shri Krishna Hrudayalaya & Critical Care Centre Nagpur, Maharashtra | |
| Shri Mahant Indiresh Hospital Dehradun, | |
| Sichuan Provincial People's Hospital-Cardiology Chengdu, Sichuan | |
| Sir Ganga Ram Hospital New Delhi, | |
| Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou, | |
| Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou, | |
| Sismanogleio General Hospital - Cardiology Department Marousi, | |
| Sourasky MC - Cardio Vascular Research Center Tel Aviv, | |
| South Oklahoma Heart Research, LLC Oklahoma City, Oklahoma | |
| South Oklahoma Heart Research, LLC Oklahoma City, Oklahoma | |
| Southlake Regional Hlth Centre Newmarket, Ontario | |
| Southlake Regional Hlth Centre Newmarket, Ontario | |
| Specialized Hospital For Active Cardiology Treatement Cardiolife OOD Varna, | |
| Specjalistyczny Szpital Im. E. Szczeklika W Tarnowie Tarnów, Lesser Poland Voivodeship | |
| Specjalistyczny Szpital Im. E. Szczeklika W Tarnowie Tarnów, Lesser Poland Voivodeship | |
| Specjalistyczny Szpital Miejski im. M.Kopernika w Toruniu Torun, | |
| Sri Jayadeva Institute of Cardiovascular Sciences & Research Bengaluru, Karnataka | |
| Sri Ramachandra Medical Centre Chennai, Tamil Nadu | |
| Sri Ramachandra Medical Centre Chennai, Tamil Nadu | |
| Ss. Annunziata Chieti, Abruzzo | |
| St Bartholomew's Hospital - Barts Heart Centre London, | |
| St Francis Hospital Lindner Research Center Roslyn, New York | |
| St Francis Hospital Lindner Research Center Roslyn, New York | |
| St. Boniface Hospital Winnipeg, Manitoba | |
| St. Boniface Hospital Winnipeg, Manitoba | |
| St. Luke's Idaho Cardiology Associates Meridian, Idaho | |
| St. Michael's Hospital Toronto, Ontario | |
| St. Michael's Hospital Toronto, Ontario | |
| St.Mary's Hospital_Cardiology Fukuoka, | |
| Sterling Hospitals, Race Course Road Vadodara, Gujarat | |
| Stony Brook University Hospital Stony Brook, New York | |
| Städt. Klinikum Dresden - 2. Medizinische Klinik Dresden, | |
| Sultan Ahmad Shah Medical Centre @IIUM Kuantan, Pahang | |
| Sunnybrook Health Sciences Centre Toronto, Ontario | |
| Sunnybrook Health Sciences Centre Toronto, Ontario | |
| Sunshine Coast University Hospital - Clinical Research Unit Birtinya, Queensland | |
| Sunshine Hospital - Western Centre for Health Research and Education St Albans, Victoria | |
| Svendborg Sygehus - Kardiologisk Svendborg, | |
| Swedish Medical Center_Seattle Seattle, Washington | |
| Szpital Grochowski im. dr med. Rafala Masztaka Sp. z o.o. Warsaw, | |
| Szpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o. Warsaw, | |
| Szpital Miejski Nr 4 w Gliwicach Sp. z o.o., Oddzial Kardiologii Gliwice, Silesian Voivodeship | |
| Szpital Uniwersytecki Nr 2 im. Dr. Jana Biziela Bydgoszcz, | |
| Szpital Wolski im. dr Anny Gostyńskiej Sp. z o.o. Warsaw, | |
| Szpitale Pomorskie Sp. z o.o. Gdynia, Pomeranian Voivodeship | |
| TEDA International Cardiovascular Hospital-Cardiovascular Tianjin, Tianjin Municipality | |
| Teda International Cardiovascular Hospital Binhai, | |
| Teikyo University Hospital_Cardiology Tokyo, | |
| Tennova HC Turkey Creek MC Knoxville, Tennessee | |
| Tergooi, Hilversum Hilversum, | |
| Texas Heart Inst Medical Ctr Houston, Texas | |
| The 1st Affiliated Hospital of WMU-Cardiology Wenzhou, Zhejiang | |
| The Alfred - Endocrinology & Diabetes Department South Yarra, Victoria | |
| The Catholic University of Korea, Bucheon St. Mary's Hospital Bucheon-si, Gyeonggi-do | |
| The Catholic University of Korea, Seoul St. Mary's Hospital Seoul, | |
| The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang | |
| The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang | |
| The First Affiliated Hospital of WMU-Cardiology Wenzhou, Zhejiang | |
| The First Affiliated Hospital of Xi'an Jiaotong University-Cardiovascular Xi'an, Shaanxi | |
| The First Affiliated hospital of Fujian Medical University Fuzhou, Fujian | |
| The First Affiliated hospital of Fujian Medical University Fuzhou, Fujian | |
| The Heart House Haddon Heights Haddon Heights, New Jersey | |
| The James Cook University Hospital - Cardiology Middlesbrough, | |
| The Madras Medical Mission Chennai, Tamil Nadu | |
| The New York Hospital Brooklyn, New York | |
| The People's Hospital of Guangxi Zhuang Autonomous Region Nanning, Guangxi | |
| The People's Hospital of Liaoning Province Shenyang, Liaoning | |
| The People's Hospital of Liaoning Province-Cardiology Shenyang, Liaoning | |
| The Prince Charles Hospital Chermside, Queensland | |
| The Prince Charles Hospital Chermside, Queensland | |
| The Sakakibara Heart Institute of Okayama_Department of Cardiovascular Medicine Okayama, | |
| The Sakakibara Heart Institute of Okayama_Department of Cardiovascular Medicine Okayama, | |
| The Second Affiliated Hospital Of Chongqing Medical University Chongqing, | |
| The Second Affiliated Hospital Of Chongqing Medical University Chongqing, | |
| The Second Affiliated Hospital of Nanjing Medical university Nanjing, Jiangsu | |
| The Second Affiliated Hospital of Nanjing Medical university Nanjing, Jiangsu | |
| The Second Xiangya Hospital of Central South University Changsha, Hunan | |
| The Second Xiangya Hospital of Central South University Changsha, Hunan | |
| Thoracic General Hospital Of Athens I Sotiria - Cardiology Department Athens, | |
| Tianjin People's Hospital Tianjin, Tianjin Municipality | |
| Tianjin People's Hospital Tianjin, Tianjin Municipality | |
| Toho University Sakura Medical Center_Cardiology Chiba, | |
| Tohoku University Hospital, Cardiovascular Sendai-shi, Miyagi, | |
| Tokai University Hospital_Cardiology Kanagawa, | |
| Tokai University Hospital_Cardiology Kanagawa, | |
| Tokat Gaziosmanpaşa Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji Tokat Province, | |
| Tokushima Prefectural Central Hospital_Cardiology Tokushima, | |
| Tokushima Prefectural Central Hospital_Cardiology Tokushima, | |
| Torbay Hospital - Cardiology Torquay, Devon | |
| Torrance Memorial Medical Center Torrance, California | |
| Townsville University Hospital Douglas, Queensland | |
| Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji Edirne, | |
| Trinity Health Michigan Heart Ypsilanti, Michigan | |
| Trinity Health Oakland Hospital Pontiac, Michigan | |
| Trinity Medical Group Minot, North Dakota | |
| Trinity Medical Group Minot, North Dakota | |
| Trinity Medical WNY, PC Buffalo, New York | |
| Tsuchiura Kyodo General Hospital_Internal Medicine Ibaraki, | |
| Tsuchiura Kyodo General Hospital_Internal Medicine Ibaraki, | |
| Tsukuba Medical Center Hospital_Department of Cardiology Tsukuba-shi, Ibaraki, | |
| U.G.H of Athens "Attikon" Chaidari, Athens, | |
| UCSD Medical Center San Diego, California | |
| UF Hlth Jacksonville Jacksonville, Florida | |
| UHN-Toronto General Hospital Toronto, Ontario | |
| UHN-Toronto General Hospital Toronto, Ontario | |
| UMAE Hospital IMSS Monterrey, Nuevo León | |
| UMC Groningen - Cardiologie Groningen, | |
| UMC of Southern Nevada Las Vegas, Nevada | |
| UMHAT "Sveta Marina" EAD Varna, | |
| UMHAT - Burgas AD Burgas, | |
| UMHAT Aleksandrovska EAD, Clinic of Cardiology Sofia, | |
| UMHAT Deva Maria EOOD Burgas, | |
| UMHAT Pulmed OOD - Plovdiv, Department of Cardiology Plovdiv, | |
| UMHAT Sofiamed EAD Sofia, | |
| UMHAT Sveta Anna Sofia AD, Clinic of Cardiology Sofia, | |
| UMHAT Sveta Ekaterina EAD Sofia, | |
| UMHAT Sveta Marina EAD, Second Clinic of Cardiology Varna, | |
| UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology Plovdiv, | |
| UMHATEM N.I. Pirogov EAD Sofia, | |
| UNC Hospital HVC_Meadowmont Chapel Hill, North Carolina | |
| UT Health University of Texas Houston, Texas | |
| Unidad Medica de Alta Especialidad No. 71 IMSS Torreón, Coahuila | |
| Unidad Medica de Alta Especialidad No. 71 IMSS Torreón, Coahuila | |
| Uniklinik Klinikum Bielefeld - Kardiologie und Internist. Intensivmedizin Bielefeld, | |
| Uniklinik Regensburg - Innere Medizin II Regensburg, | |
| Uniklinik TU Dresden - Herzzentrum Dresden GmbH Dresden, | |
| Uniklinik Tübingen - Innere Med. III Kardiologie und Angiologie Tübingen, | |
| UniklinikHeidelberg - Innere Med. III - Kardiologie, Angiologie, Pneumologie Heidelberg, | |
| Union Hospital Tongji Medical College Huazhong University of Science and Technology-Cardiology Wuhan, Hubei | |
| Univ Gen Hospital Larisa, Cardiology Medicine Clinic Larissa/Thessaly, | |
| Univ of Alberta Hosp Edmonton Edmonton, Alberta | |
| Univ of Mississippi Med Center Jackson, Mississippi | |
| Universiti Teknologi MARA, Sungai Buloh Campus Sungai Buloh, Selangor | |
| University General Hospital of Ioannina,Internal Medicine Ioannina, | |
| University General Hospital of Ioannina,Internal Medicine Ioannina, | |
| University Hospitals of Cleveland Medical Center Elyria, Ohio | |
| University Malaya Medical Centre Lembah Pantai, | |
| University Medical Center New Orleans New Orleans, Louisiana | |
| University Of Washington_Seattle Seattle, Washington | |
| University of CO - Division of Cardiology Aurora, Colorado | |
| University of Californ LA-UCLA Los Angeles, California | |
| University of California Irvine Irvine, California | |
| University of Cincinnati/UC Health Cincinnati, Ohio | |
| University of Florida Gainesville, Florida | |
| University of Kansas Hospital Kansas City, Kansas | |
| University of Louisville Louisville, Kentucky | |
| University of Ottawa Heart Ins Ottawa, Ontario | |
| University of Rochester Rochester, New York | |
| University of Texas Medical Branch Galveston, Texas | |
| University of Texas Southwestern Medical Center Dallas, Texas | |
| University of Toledo Toledo, Ohio | |
| University of Virginia Charlottesville, Virginia | |
| Universitätsklinikum Düsseldorf - Klinik für Kardiologie, Pneumologie und Angiologie Düsseldorf, | |
| Universitätsklinikum Frankfurt aM - Kardiologie Frankfurt am Main, | |
| Universitätsklinikum Freiburg - Medical Center Freiburg im Breisgau, | |
| Universitätsklinikum Hamburg-Eppendorf - University Medical Center Hamburg-Eppendorf Hamburg, | |
| Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie Leipzig, | |
| Universitätsklinikum Mannheim - 1. Medizinische Klinik Mannheim, | |
| Uniwersytecki Szpital Kliniczny Nr 2 PUM W Szczecinie Szczecin, | |
| Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi Lodz, Łódź Voivodeship | |
| Uniwersytecki Szpital Kliniczny W Poznaniu Poznan, | |
| Uniwersytecki Szpital Kliniczny W Poznaniu Poznan, | |
| Uniwersytecki Szpital Kliniczny nr 2 Uniwersytetu Medycznego w Łodzi Lodz, | |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Bialystok, | |
| Uniwersytecki Szpital Kliniczny w Opolu Opole, | |
| Uniwersytecki Szpital Kliniczny w Opolu Opole, | |
| Uniwersyteckie Centrum Kliniczne (UCK) Gdansk, | |
| Uniwersyteckie Centrum Kliniczne (UCK) Gdansk, | |
| Uniwersyteckie Centrum Kliniczne WUM Warsaw, | |
| Uniwersyteckie Centrum Kliniczne WUM Warsaw, | |
| VA Medical Center_Minneapolis Minneapolis, Minnesota | |
| VA Medical Center_Salem Salem, Virginia | |
| VAGrtrLosAngelesHlthcareSystem Los Angeles, California | |
| Valley Clinical Trials Northridge, California | |
| Valley Clinical Trials Northridge, California | |
| Valley Health Link Winchester, Virginia | |
| Vancouver General Hospital Vancouver, British Columbia | |
| Vanderbilt University Medical Center Nashville, Tennessee | |
| Vanderbilt University Medical Center Nashville, Tennessee | |
| Vardhaman Mahavir Medical College & Safdarjung Hospital New Delhi, National Capital Territory of Delhi | |
| Vijan Hospital & Research Centre Nashik, Maharashtra | |
| Virginia Commonwealth University Health System Richmond, Virginia | |
| Virtua Health Camden, New Jersey | |
| WMU Homer Stryker MD School of Medicine Kalamazoo, Michigan | |
| Wake Forest Uni Hlth Sciences High Point, North Carolina | |
| Washington University School of Medicine_St. Louis St Louis, Missouri | |
| Wayne State University/University Health Center Detroit, Michigan | |
| West China Hospital Sichuan University-Cardiology Chengdu, Sichuan | |
| West China Hospital Sichuan University-Cardiology Chengdu, Sichuan | |
| Westchester Medical Center Valhalla, New York | |
| Westchester Medical Center Valhalla, New York | |
| William Harvey Hospital Ashford, Kent | |
| William Harvey Hospital Ashford, Kent | |
| William Osler Hel Bra Civic Hs Brampton, Ontario | |
| William Osler Hel Bra Civic Hs Brampton, Ontario | |
| Winter Haven Hospital Winter Haven, Florida | |
| Winter Haven Hospital Winter Haven, Florida | |
| Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu Przemyśl, | |
| Wojewodzki Szpital Specjalistyczny W Bialej Podlaskiej Biała Podlaska, | |
| Wojewodzki Szpital Specjalistyczny We Wroclawiu Wroclaw, | |
| Wojewodzki Szpital Specjalistyczny We Wroclawiu Wroclaw, | |
| Wojewodzki Szpital Zespolony W Elblagu samodzielny publiczny zakład opieki zdrowotnej Elblag, | |
| Wojewodzki Szpital Zespolony W Elblagu samodzielny publiczny zakład opieki zdrowotnej Elblag, | |
| Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego, Lodz, | |
| Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego, Lodz, | |
| Wojewódzki Szpital Specjalistyczny im. NMP w Częstochowie Częstochowa, | |
| Wojewódzki Szpital Zespolony im. dr. Romana Ostrzyckiego w Koninie Konin, | |
| Wolfson MC - The Heart Institute Holon, | |
| Wonju Severance Christian Hospital Wŏnju, | |
| Wright State University Fairborn, Ohio | |
| Xiangya Hospital Central-South University Changsha, Hunan | |
| Xiangya Hospital Central-South University Changsha, Hunan | |
| Yale Ctr for Clin Invest New Haven, Connecticut | |
| Yokohama City University Hospital Kanagawa, Yokohama, | |
| Yokohama City University Hospital Kanagawa, Yokohama, | |
| Yokohama City University Medical Center_Cardiovascular Center Kanagawa, | |
| Yokohama City University Medical Center_Cardiovascular Center Kanagawa, | |
| Yokohama Municipal Citizen's Hospital_Cardiology Kanagawa, | |
| Zespol Zakladow Opieki Zdrowotnej w Ostrowie Wielkopolskim Ostrów Wielkopolski, Greater Poland Voivodeship | |
| Zespół Zakładów Opieki Zdrowotnej w Ostrowie Wielkopolskim Ostrów Wielkopolski, Greater Poland Voivodeship | |
| Zhejiang Hospital, Zhejiang University School of Medicine Hangzhou, | |
| Zhejiang Hospital-Cardiology Hangzhou, Zhejiang | |
| Zhongda Hospital Southeast University Nanjing, | |
| Zhongda Hospital, Southeast University Nanjing, | |
| Zhongshan Hospital, Fudan University-Cardiology Shanghai, Shanghai Municipality | |
| İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Hastanesi- Prof. Dr. Murat Dilmener Yerleşkesi Istanbul, Bakirkoy | |
| İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü Istanbul, | |
| Śródmiejskie Centrum Kliniczne,II Oddział Kardiologii MSB, Klinika Chorób Serca CMKP Warsaw, |
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation (REACT-AF)
Anna Baranova - anna.baranova2@vcuhealth.org
NCT05836987
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Inclusion Criteria:
• 22-85 years of age.
• English speaking participants. Spanish-only speakers may be included in the future at select sites appropriately translated.
• History of non-permanent atrial fibrillation.
• CHA2DS2-VASC score of 1-4 for men and 2-4 for women without prior stroke or Transient Ischemic Attack (TIA), The CHA2DS2-VASc score is a point-based system used to stratify the risk of stroke in Atrial Fibrillation (AF) patients. The acronym CHA2DS2-VASc stands for congestive heart failure, hypertension, age ≥75 (doubled), diabetes, stroke (doubled), vascular disease, age 65 to 74 and sex category (female). Congestive heart failure defined as: The presence of signs and symptoms of either right (elevated central venous pressure, hepatomegaly, dependent edema) or left ventricular failure (exertional dyspnea, cough, fatigue, orthopnea, paroxysmal nocturnal dyspnea, cardiac enlargement, rales, gallop rhythm, pulmonary venous congestion) or both, confirmed by non-invasive or invasive measurements demonstrating objective evidence of cardiac dysfunction and/or ejection fraction \< 40%.
• The participant is on a DOAC at the time of screening and willing to stay on DOAC for duration of study.
• Willing and able to comply with the protocol, including: * Possession of a smart watch-compatible smart phone (iPhone that supports the latest shipping iOS) with a cellular service plan * Be willing to wear the smart watch for the suggested minimum of 14 hours a day * Expected to be within cellular service range at least 80% of the time
• Willing and able to discontinue DOAC
• The participant is willing and able to provide informed consent.
Exclusion Criteria:
• Valvular or permanent atrial fibrillation.
• Current treatment with warfarin and unwilling or unable to take a DOAC.
• The participant is a woman who is pregnant or nursing.
• The participant is being treated with chronic aspirin, another anti-platelet agent, or chronic NSAIDS outside of current medical guidelines (e.g., primary stroke prevention in patients with atrial fibrillation, primary prevention of cardiovascular events, pain relief, fever, gout) and is unwilling or unable to discontinue use for the study duration.
• Existing cardiac rhythm device or indication for a permanent pacemaker, Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronization Therapy (CRT) device or planned insertable cardiac monitor. Insertable cardiac monitors are permitted unless they are being used to guide anticoagulation treatment.
• Known or suspected symptomatic or asymptomatic atrial fibrillation lasting ≥ 1 hour/month over the last 3 months.
• Any documented single AF episode lasting ≥ 1 hour on standard of care or study-provided external cardiac monitor of \> 6 days duration performed within 45 days prior to randomization. Shorter monitoring durations may be acceptable for inclusion at the discretion of the site PI based on the totality of monitoring data and approval of the study PI.
• Ablation for AF within the last 2 months.
• Prior or anticipated left atrial appendage occlusion or ligation.
• Mechanical prosthetic valve(s) or severe valve disease.
• Hypertrophic cardiomyopathy.
• Participant needs DOAC for reasons other than preventing stroke or arterial embolism resulting from AF (i.e., preventing Deep Vein Thrombosis (DVT) or PE) or needs permanent OAC (i.e., congenital heart defects, prosthetic heart valve).
• Participants deemed high risk for non-cardioembolic stroke (i.e., significant carotid artery disease defined as stenosis \> 75%) based on the investigator's discretion.
• The participant is enrolled, has participated within the last 30 days, or is planning to participate in a concurrent drug and/or device study during the course of this clinical trial. Co-enrollment in concurrent trials is only allowed with documented pre-approval from the study manager; there is no concern that co-enrollment could confound the results of this trial.
• The participant has a tattoo, birthmark, or surgical scar over the dorsal wrist area on the ipsilateral side that the AFSW may be worn.
• The participant has a tremor on their ipsilateral side that the AFSW may be worn.
• Any concomitant condition that, in the investigator's opinion, would not allow safe participation in the study (e.g., drug addiction, alcohol abuse).
• Known hypersensitivity or contraindication to direct oral anticoagulants.
• Documented prior stroke (ischemic or hemorrhagic) or transient ischemic attack.
• Reversible causes of AF (e.g., cardiac surgery, pulmonary embolism, untreated hyperthyroidism). AF ablation does not constitute reversible AF.
• \> 5% burden of premature atrial or ventricular depolarizations on pre-enrollment cardiac monitoring.
• History of atrial flutter that has not been treated with ablation (participants in atrial flutter and have been ablated are eligible for enrollment).
• Stage 4 or 5 chronic kidney disease.
• Conditions associated with an increased risk of bleeding: * Major surgery in the previous month * Planned surgery or intervention in the next three months that would require cessation of anticoagulation \> 2 weeks. * History of intracranial, intraocular, spinal, retroperitoneal, or atraumatic intra- articular bleeding * Gastrointestinal hemorrhage within the past year unless the cause has been permanently eliminated (e.g., by surgery) * Symptomatic or endoscopically documented gastroduodenal ulcer disease in the previous 30 days * Hemorrhagic disorder or bleeding diathesis * Need for anticoagulant treatment for disorders other than AF * Uncontrolled hypertension (Systolic Blood Pressure \>180 mmHg and/or Diastolic Blood Pressure \>100 mmHg)
DEVICE: AFSW Guided DOAC, DRUG: Continuous DOAC therapy
Atrial Fibrillation
Atrial Fibrillation, Anticoagulation, AF-sensing Smart Watch, Ischemic Stroke, Systemic Embolism
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Show 93 locations
Study Locations
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| Location | Contacts |
|---|---|
| Advanced Heart and Vascular Institute of Hunterdon Flemington, New Jersey | Alexis Bellafiore - (abellafiore@ahvi-nj.com) Jessica Senatore - (jsenatore@ahvi-nj.com) |
| Alexian Brothers Health System Elk Grove Village, Illinois | Michelle Garcia - (michelle.garcia5@ascension.org) Jeanine Pilat - (jeanine.pilat@ascension.org) |
| Allegheny Singer Research Institute Pittsburgh, Pennsylvania | Caitlin Phalunas - (caitlin.phalunas@ahn.org) Elizabeth Belden - (elizabeth.belden@ahn.org) |
| Ascension St. Vincent Indianapolis, Indiana | Regina Margiotti - (regina.margiotti@ascension.org) Ann Renick - (anne.renick@ascension.org) |
| BMC - Brighton Boston, Massachusetts | Rina Vaquerano - (rina.vaquerano@steward.org) |
| Banner University Phoenix, Arizona | Herisse Sabulao - (herisse.sabulao@bannerhealth.com) Raeven Maxwell - (raeven.maxwell@bannerhealth.com) |
| BayCare Health Systems Clearwater, Florida | Karen Herring - (karen.herring@baycare.org) |
| Baycare Health Systems Clearwater Winter Haven, Florida | Amanda Steadham - (Amanda.Steadham@baycare.org) Lynda Argenzio - (lynda.argenzio@baycare.org) |
| Baylor College of Medicine Houston, Texas | Stephen Harold - (harold@bcm.edu) |
| Beth Israel Deaconess Medical Center Boston, Massachusetts | Jenifer M Kaufman - (jmkaufma@bidmc.harvard.edu) Patricia Tyler - (ptyler@bidmc.harvard.edu) |
| Boston Medical Center Boston, Massachusetts | Laura Gavrilles - (laura.gavrilles@bmc.org) |
| Brigham and Women's Hospital Boston, Massachusetts | Daniela Hincapie Tabres - (dhincapietabares@bwh.harvard.edu) Obadah Aloum - (OALOUM@BWH.HARVARD.EDU) |
| Cardiology Consultants of Philadelphia Paoli, Pennsylvania | Hope Bernhardy - (hopeb@ccpdocs.com) |
| Cleveland Clinic Florida Weston, Florida | |
| Columbia University Medical Center New York, New York | Raghd Ahmed - (ria2120@cumc.columbia.edu) |
| Corewell Health (Former Spectrum Health) Grand Rapids, Michigan | Lisa Van Loo - (lisa.vanloo@spectrumhealth.org) Jose Gavina - (jose.gavina@corewellhealth.org) |
| Emory University Atlanta, Georgia | Thomas Preiser - (tpreise@emory.edu) |
| Essentia Health The Duluth Clinic Duluth, Minnesota | |
| Georgia Arrhythmia Consultants and Research Institute Warner Robins, Georgia | Heather Maschenik - (hmaschenik@gacri.com) |
| Hackensack Meridian Health Hackensack, New Jersey | Patricia Arakelian - (Patricia.Arakelian@hmhn.org) |
| Hennepin Healthcare Research Institute Minneapolis, Minnesota | Sahil Thummar - (sthummar@bermancenter.org) |
| Henry Ford Health Detroit, Michigan | Briita Wanhala - (bwanhal1@hfhs.org) Danielle Delmotte - (ddelmot2@hfhs.org) |
| Houston Methodist Hospital Houston, Texas | Chinwe Ngumezi - (ccngumezi@houstonmethodist.org) |
| James River Cardiology Chesterfield, Virginia | Janet Barrett - (Janet.Barrett@alignedcardio.com) |
| Johns Hopkins Univeristy Baltimore, Maryland | Michele Martucci - (mmill148@jhmi.edu) Natalie Horstman - (nhorstm3@jhu.edu) |
| Kaiser Permanente Fresno, California | Annie Lei - (Annie.X.Lei@kp.org) Quyen Chau - (Quyen.X.Chau@kp.org) |
| Lahey Hospital & Medical Center Burlington, Massachusetts | Jean Byrne - (jean.byrne@lahey.org) |
| Loyola University Chicago Chicago, Illinois | Nancy Schoenecker - (nschoenecker@luc.edu) Jean Del Priore - (jdelpri@luc.edu) |
| MUSC Health Heart and Vascular Columbia, South Carolina | Jacqueline Sheriod-Scott - (sheriods@musc.edu) |
| Maine Medical Partners MaineHealth Cardiology Scarborough, Maine | Hilary Curtis - (hilary.curtis@mainehealth.org) Brenda Galsgow - (brenda.glasgow@mainehealth.org) |
| Mass General Hospital Boston, Massachusetts | Kristen Steinmetz - (ksteinmetz@mgh.harvard.edu) |
| Mayo Clinic Rochester, Minnesota | Pamela Wong - (WongLucio.Pamela@mayo.edu) |
| Medical College of Wisconsin Froedtert Hospital Milwaukee, Wisconsin | Debbi Hoff - (dhoff@mcw.edu) |
| Medical Faculty Associates George Washington University Washington D.C., District of Columbia | |
| Medical University of South Carolina Charleston, South Carolina | Krista Szymanski - (szymankr@musc.edu) |
| Midwest Cardiovascular Institute Naperville, Illinois | Josilyn Klimek - (Josilyn.Klimek@cardio.com) |
| Minneapolis Heart Institute Foundation Minneapolis, Minnesota | Andrew Garner - (andrew.garner@allina.com) Julianne Feola - (julianne.feola@allina.com) |
| NYU Langone Health New York, New York | Mollie Machado - (mollie.machado@nyulangone.org) |
| NewYork Presbyterian - Queens Queens, New York | Jackson Ng - (jan9044@nyp.org) |
| NorthShore University Healthsystem Evanston, Illinois | Marisa Durante - (mdurante@northshore.org) |
| Northwestern University Chicago, Illinois | CTU Regulatory Team - (cturegulatoryteam@nm.org) |
| Ohio State University Medical Center Columbus, Ohio | Adrianne Miller - (adrianne.miller3@osumc.edu) Kalyn Ferguson - (kalyn.ferguson@osumc.edu) |
| OhioHealth Research Institute Westerville, Ohio | Reem Bekheet - (reem.bekheet@ohiohealth.com) |
| Penn State Health Medical Group Berks Cardiology Wyomissing, Pennsylvania | Emese Futchko - (efutchko@pennstatehealth.psu.edu) Michelle Feltenberger - (mfeltenberger@pennstatehealth.psu.edu) |
| Presbyterian Healthcare Services Albuquerque, New Mexico | |
| Rhode Island Hospital Providence, Rhode Island | Kelly Franchetti - (kfranchetti@brownhealth.org) |
| Rush University Medical Center Chicago, Illinois | Nusrat Jahan - (nusrat_jahan@rush.edu) Christine Radochonski - (Christine_Radochonski@rush.edu) |
| Rutgers, the State University of New Jersey Piscataway, New Jersey | Glaucia Dos Santos-Vaccaro - (gd301@rwjms.rutgers.edu) |
| Sarasota Memorial Health Care System Sarasota, Florida | Jennifer Jordan - (Jennifer-Jordan@smh.com) Colleen Lindner - (Colleen-Lindner@smh.com) |
| Scripps Health San Diego, California | Janet Lawrence - (Lawrence.Janet@scrippshealth.org) |
| South Denver Cardiology Associates, P.C. Littleton, Colorado | Kathrin Siegel - (ksiegel@southdenver.com) |
| St. Elizabeth's Medical Center Washington D.C., District of Columbia | Rina Vaquerano - (rina.vaquerano@steward.org) |
| St. Joseph Medical Center Tacoma Tacoma, Washington | Boyoung Moore - (boyoung.moore@vmfh.org) |
| Stanford University Stanford, California | Anna Schonhorn - (aschon@stanford.edu) |
| Staten Island University Hospital-Northwell Health Staten Island, New York | Alexandra Pantea - (apantea@northwell.edu) |
| Stony Brook University Stony Brook, New York | Melanie Rooney - (melanie.rooney@stonybrookmedicine.edu) Michelle Xikis - (Michele.xikis@stonybrookmedicine.edu) |
| Texas Cardiac Arrhythmia Research Foundation Austin, Texas | Deb Cardinal - (dscardinal@austinheartbeat.com) |
| The Lindner Center for Research and Education at The Christ Hospital Cincinnati, Ohio | Anne Voorhorst - (anne.voorhorst@thechristhospital.com) Rebecca Harper - (RebeccaM.Harper@thechristhospital.com) |
| The Valley Hospital, Inc. Paramus, New Jersey | RoseMarie Hroncich - (rhronci@valleyhealth.com) |
| Thomas Jefferson University Philadelphia, Pennsylvania | Ashley Borgella - (ashley.borgella@jefferson.edu) |
| Trinity Health Grand Rapids/Mercy Health Grand Rapids, Michigan | Melissa Brown-Culbertson - (melissa.brown-culbertson@trinity-health.org) Nicolina Evola - (Nicolina.evola@trinity-health.org) |
| Trinity Health Michigan Heart - Ann Arbor Ypsilanti, Michigan | Autumn Howe - (ahowe@michiganheart.com) |
| Tufts Medical Center Boston, Massachusetts | Juan Carlos Collado Falcon - (Juan.Carlos.Collado.Falcon@tuftsmedicine.org) Abena Adwetewa-Badu - (Abena.Adwetewa-Badu@tuftsmedicine.org) |
| UC Davis Health Sacramento, California | Edward Lingayo - (lingayo@health.ucdavis.edu) |
| UMass Chan Medical School Worcester, Massachusetts | |
| University Health Truman Medical Center Kansas City, Missouri | |
| University at Buffalo Buffalo, New York | Courtney Bishop - (cabishop@buffalo.edu) Cassandra Davern - (cadavern@buffalo.edu) |
| University of California Los Angeles (UCLA Health) Los Angeles, California | Monserrath Campos - (monserrathcampos@mednet.ucla.edu) |
| University of Chicago Chicago, Illinois | Shahram Sarrafi - (ssarrafi1@uchicagomedicine.org) Kie Ng - (kie@bsd.uchicago.edu) |
| University of Cincinnati College of Medicine Cincinnati, Ohio | Elias Shamieh - (shamiees@ucmail.uc.edu) |
| University of Colorado Denver, Colorado | Megan Collett - (megan.collett@uchealth.org) |
| University of Florida Gainesville, Florida | Walter Erikson - (erikson.walter@medicine.ufl.edu) Vanessa Scheuble - (vanessa.scheuble@medicine.ufl.edu) |
| University of Illinois Chicago Chicago, Illinois | Muriel Chen - (yining@uic.edu) |
| University of Iowa Hospitals and Clinics Iowa City, Iowa | Trisha Elliott - (trisha-elliott@uiowa.edu) |
| University of Miami - Leonard S. Miller SOM Miami, Florida | Carmen Maria Baez-Garcia - (cbaezgarcia@med.miami.edu) |
| University of Minnesota Minneapolis, Minnesota | Julie Dicken - (dicke022@umn.edu) Maddy Chopp - (Chopp015@umn.edu) |
| University of New Mexico Health Sciences Center Albuquerque, New Mexico | Elvia Padilla - (EPadillaMendez@salud.unm.edu) Noela Garcia-Soberanez - (NGarciaSoberanez@salud.unm.edu) |
| University of North Carolina Chapel Hill, North Carolina | Meghan Allen - (meghme@med.unc.edu) Elias Wen - (elias_wen@med.unc.edu) |
| University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma | Kylie Ricci - (kylie-ricci@ouhsc.edu) Aurora Vera - (aurora-vera@ouhsc.edu) |
| University of Southern California - Keck School of Medicine Los Angeles, California | Rohit Varma - (RohitVarma.Penmetsa@med.usc.edu) Stephanie Chao - (Stephanie.Chao@med.usc.edu) |
| University of Texas Health Science Center at Houston Houston, Texas | Mary Pierce - (mary.h.pierce@uth.tmc.edu) Vickie Ramirez - (vickie.m.ramirez@uth.tmc.edu) |
| University of Texas Southwestern Medical Center Dallas, Texas | Vukile Mlambo - (vukile.mlambo@utsouthwestern.edu) |
| University of Utah Salt Lake City, Utah | Andy Rivera - (andy.rivera@hsc.utah.edu) |
| University of Virginia Charlottesville, Virginia | Cathy Roy - (cjp6t@virginia.edu) |
| University of Wisconsin Madison, Wisconsin | Karen Olson - (kjolson@medicine.wisc.edu) Emma Rolf - (erolf@medicine.wisc.edu) |
| Virginia Commonwealth University Richmond, Virginia | Anya Baranova - (Anna.Baranova2@vcuhealth.org) |
| Wake Forest Baptist Health Winston-Salem, North Carolina | Keishia Rodriguez - (kyrodrig@wakehealth.edu) Mohammed Mostafa - (mmostafa@wakehealth.edu) |
| Washington University School of Medicine St Louis, Missouri | Kyle Smith - (kyle.smith1@wustl.edu) Sharon Heuerman - (sheuerman@wustl.edu) |
| Weill Medical College of Cornell University New York, New York | Dolores Reynolds - (dtr2001@med.cornell.edu) |
| Westchester Medical Center Valhalla, New York | Allyson Pulsoni - (allyson.pulsoni@wmchealth.org) Erida Castro-Rivas - (Erida.Castro@wmchealth.org) |
| White Plains Hospital White Plains, New York | Aileen Ferrick - (aferrick@wphospital.org) Uloma Ijomah - (uijomah@wphospital.org) |
| William Beaumont Hospital Royal Oak, Michigan | Lisa Carney - (lisa.carney2@corewellhealth.org) |
| Wooster Community Hospital Wooster, Ohio | Erica Stahl - (estahl@wchosp.org) |
Left vs Left Randomized Clinical Trial
Mihail G Chelu, MD, PhD - leftvsleft@bcm.edu
NCT05650658
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Inclusion Criteria:
* Men and women 18 years of age or older.
* A LVEF ≤ 50% within 6 months prior to enrollment.
* Resting QRS duration ≥130 ms as evidenced by a historical 12-lead ECG prior to enrollment OR anticipated right ventricular pacing \>40% OR device in place with right ventricular pacing \> 40%.
* Are optimized on HF guideline directed medical therapy according to current HF published guidelines OR patient's physician will make an effort to start all guideline-directed medical therapy and titrate doses up as permitted by the participant clinical status and co-morbidities prior to implantation procedure.
Exclusion Criteria:
* Women who are pregnant, lactating, or plan to become pregnant during the course of the trial.
* Participants with angiographic evidence of coronary disease who are candidates for coronary revascularization and are likely to undergo coronary artery bypass graft surgery or percutaneous coronary, intervention in the next three (3) months.
* Enzyme-positive myocardial infarction within the past three (3) months prior to enrollment.
* Coronary artery bypass graft surgery or percutaneous coronary intervention (balloon and/or stent angioplasty) within the past three (3) months prior to enrollment.
* Reversible non-ischemic cardiomyopathy (e.g., acute viral myocarditis).
* Participants with Chagas disease, cardiac sarcoidosis or amyloidosis.
* Expected to receive left ventricular assist device or heart transplantation within 6 months.
* Participants with primary severe valvular disease (e.g., aortic stenosis).
* Have a life expectancy of less than 12 months.
* Participants with irreversible brain damage from preexisting cerebral disease.
* Participants with a contrast dye allergy unable or unwilling to undergo pretreatment with steroids and/or diphenhydramine.
* Participants participating in any other interventional cardiovascular clinical trial.
* Participants who would be unable to comply with the study's follow-up visit schedule; or
* Participants who had any prior unsuccessful attempt at implantation of biventricular pacing (BiVP), His Bundle Pacing (HBP), or Left Bundle Branch Pacing (LBBP) device. DEVICE: His/LBBP, DEVICE: BiVP
Heart Failure, Heart Failure With Reduced Ejection Fraction, AV Block, LBBB, RBBB, Intraventricular Conduction Delay, Pacing-Induced Cardiomyopathy
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Show 71 locations
Study Locations
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| Location | Contacts |
|---|---|
| Allegheny-Singer Research Institute Pittsburgh, Pennsylvania | Minesh Lathia - (minesh.lathia@ahn.org) |
| Baptist Health Louisville Louisville, Kentucky | Karin Cryan - (karin.cryan@BHSI.COM) |
| Baylor College of Medicine Houston, Texas | Stephen Harold - (harold@bcm.edu) |
| Beth Israel Deaconess Medical Center Boston, Massachusetts | Henry Xie - (hxie1@bidmc.harvard.edu) |
| CIS Clinical Research Corporation Naperville, Illinois | |
| CIUSSS de l'Estrie - CHUS Saint-Jean-sur-Richelieu, Quebec | Marie-Claude Grenier - (marie-claude.grenier.ciussse-chus@ssss.gouv.qc.ca) |
| Cleveland Clinic Cleveland, Ohio | Raquel Rozich - (Rozichr@ccf.org) |
| Cleveland Clinic Florida Weston, Florida | Maria Gomez Mejia - (MEJIAGM@ccf.org) |
| Columbia University Medical Center/New York-Presbyterian Hospital (CUMC/NYPH) New York, New York | Alicha Daniel - (aad2223@cumc.columbia.edu) |
| Florida Heart and Vascular, LLC dba Florida Heart Rhythm Specialist, PLLC South Pasadena, Florida | Adryanna Alban - (adryanna.alban@flahrs.com) |
| Geisinger Commonwealth School of Medicine Scranton, Pennsylvania | |
| HMH Hospitals Corporation Hackensack, New Jersey | Stephanie Lynes - (stephanie.lynes@hmhn.org) |
| Hamilton Health Sciences (HHS) Hamilton, Ontario | Kiran Qamar - (qamarulisl@HHSC.CA) |
| Hartford Hospital Hartford, Connecticut | Saskia Campbell - (Saskia.Campbell@hhchealth.org) |
| Heart Rhythm Solutions Davie, Florida | Daniela Rodriguez - (Daniela@heartrhythmsolutions.com) |
| Icahn School of Medicine at Mount Sinai New York, New York | Ugur Gurol - (Ugur.Gurol@mountsinai.org) |
| Inova Heart and Vascular Institute Falls Church, Virginia | Tracy Plummer - (tracy.plummer@inova.org) |
| Lehigh Valley Hospital Inc. Allentown, Pennsylvania | Traci L Eichelberger - (Traci.Eichelberger@jefferson.edu) |
| Lovelace Medical Center Albuquerque, New Mexico | |
| MH Mission Hospital LLLP- Asheville Cardiology Associates Asheville, North Carolina | Olivia Lim - (olivia.lim@hcahealthcare.com) |
| Massachusetts General Hospital Boston, Massachusetts | Chris Azzam - (cazzam@MGH.HARVARD.EDU) |
| Mayo Clinic Rochester, Minnesota | Axe M Ahmed - (Ahmed.Abdimajid@mayo.edu) |
| Mazankowski Alberta Heart Institute/University of Alberta Edmonton, Alberta | Lee-Ann Langkaas - (Lee-Ann.Langkaas@albertahealthservices.ca) |
| Medical University of South Carolina (MUSC) Charleston, South Carolina | Olivia Washington - (washoliv@musc.edu) |
| Mercy Gilbert & Chandler Regional Medical Centers, Gilbert AZ Gilbert, Arizona | Jacqueline Killian - (jacqueline.killian@commonspirit.org) |
| Montreal Heart Institute Montreal, Quebec | François François - (Francois.Lemarbre@icm-mhi.org) |
| Mount Sinai Medical Center of Florida, Inc. Miami Beach, Florida | Giselle Cortez - (Giselle.CortezVargas@msmc.com) |
| Newark Beth Israel Medical Center Newark, New Jersey | Patricia Policastro - (Patricia.Policastro@rwjbh.org) |
| Newmarket Electrophysiology Research Group Inc. (NERG) Newmarket, Ontario | Lynn Nyman - (lnyman@southlake.ca) |
| Northwestern University Chicago, Illinois | Katrina Martin - (katrina.martin@nm.org) |
| Nova Scotia Health Authority Halifax, Nova Scotia | Stephanie Hobbs - (Stephanie.hobbs@nshealth.ca) |
| Novant Health Charlotte, North Carolina | |
| Oregon Health & Science University Portland, Oregon | Liz Cannard - (cannarde@ohsu.edu) |
| Penn Medicine Lancaster General Lancaster, Pennsylvania | Andrew Hershey - (Andrew.Hershey@pennmedicine.upenn.edu) |
| Prisma Health-Upstate Greenville, South Carolina | Prisma Health-Upstate Shrum - (ann.shrum@prismahealth.org) |
| Research Institute of the McGill University Health Centre (RI-MUHC) - MUHC, Montreal General Hospital Montreal, | |
| Rush University Chicago, Illinois | |
| Sentara Healthcare Newport News, Virginia | |
| South Denver Cardiology Associates Littleton, Colorado | Kathrin Siegel - (ksiegel@southdenver.com) |
| St. Luke's University Health Network Easton, Pennsylvania | Kyle McFadden - (Kyle.McFadden@sluhn.org) |
| St. Mark's Hospital Salt Lake City, Utah | Pragyna Gundaboina - (Pragyna.Gundaboina@HCAhealthcare.com) |
| Sunnybrook Research Institute Toronto, Ontario | Ambreen Syeda - (ambreen.syeda@sunnybrook.ca) |
| Texas Health Research & Education Institute Arlington, Texas | Rebecca Wade - (rebeccawade@texashealth.org) |
| The Christ Hospital Cincinnati, Ohio | Susanne Pasley - (Susanne.Pasley@thechristhospital.com) |
| The MetroHealth System Cleveland, Ohio | Pete Leo - (pleo@metrohealth.org) |
| The Valley Hospital, Inc. Paramus, New Jersey | Lauren Tedeschi - (ltedesc2@Valleyhealth.com) |
| Thomas Jefferson University Hospital Philadelphia, Pennsylvania | |
| Trustees of Indiana University Indianapolis, Indiana | Molly Stearns - (mstearns2@IUHEALTH.ORG) |
| University of Arizona College of Medicine- Phoenix Tucson, Arizona | Raeven Maxwell - (Raeven.Maxwell@bannerhealth.com) |
| University of Arkansas for Medical Sciences (UAMS) Little Rock, Arkansas | Urvashi Kalola - (ukalola@uams.edu) |
| University of British Columbia Vancouver, British Columbia | Munyura Yannick - (yannick.munyura@ubc.ca) |
| University of Calgary Calgary, Alberta | |
| University of California San Diego San Diego, California | Jesus Gil - (jegil@health.ucsd.edu) |
| University of Chicago Chicago, Illinois | |
| University of Colorado (Anschutz Medical Campus) Denver, Colorado | Tanner Bloks - (tanner.bloks@cuanschutz.edu) |
| University of Florida Jacksonville Jacksonville, Florida | Latonya Been - (latonya.been@ufhealth.org) |
| University of North Carolina Chapel Hill, North Carolina | Elias Wen - (emwen@email.unc.edu) |
| University of Ottawa Heart Institute Ottawa, Ontario | Maitreya PATEL - (MaPatel@ottawaheart.ca) |
| University of Pennsylvania Philadelphia, Pennsylvania | Mary Gnap - (Mary.Gnap@pennmedicine.upenn.edu) |
| University of Pittsburg Pittsburgh, Pennsylvania | Sherry Pellegrino - (pellegrinosl@upmc.edu) |
| University of South Florida Tampa, Florida | Jacky He - (jackyhe@usf.edu) |
| University of Vermont Burlington, Vermont | Sonja Baden - (Sonja.Baden@uvmhealth.org) |
| University of Virginia Health System Charlottesville, Virginia | |
| University of Washington Seattle, Washington | Adele Stefanowicz - (amstef99@uw.edu) |
| Université Laval Québec, | Marina Sanchez - (marina.sanchez.1@ulaval.ca) |
| Victoria Cardiac Arrhythmia Trials (VCAT) Inc. Victoria, British Columbia | Matthew Coxon - (mcoxon@catrials.org) |
| Virginia Commonwealth University Richmond, Virginia | |
| Virtua Health Camden, New Jersey | Marisa Brown - (Mbrown3@virtua.org) |
| Waterloo Wellington Cardiovascular Research Institute (WWCRI) - St. Mary's General Hospital Kitchener, | |
| Weill Cornell Medicine New York, New York | Penn Collins - (gpc4001@med.cornell.edu) |
| Yale University New Haven, Connecticut | Meg Leiss - (Margaret.leiss@yale.edu) |
ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients
Jeff Lam, MS - jeff.lam@mountsinai.org
NCT05988411
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Inclusion Criteria:
* Age ≥ 18;
* Planned for a redo AF ablation procedure (paroxysmal or persistent); (prior to randomization, a technically successful AF ablation procedure, defined as successful pulmonary vein isolation, if needed, as well as bidirectional block of any attempted anatomic lesion sets such as cavotricuspid isthmus line, roofline, mitral line and superior vena cava isolation, must have been completed). Note: the clinical recurrences must primarily be atrial fibrillation, and not atrial flutter/tachycardia (that is, a prospective patient may have a AFL/AT recurrences, but AF must be the dominant recurrent rhythm.)
* History of hypertension and either:
* Documented history of SBP≥160 or DBP≥100, or;
* Receiving ≥1 antihypertensive medication;
* Willingness to adhere to study restrictions and comply with all post-procedural follow-up requirements
Exclusion Criteria:
* Long-standing persistent AF (\>12 months); \>3 prior atrial fibrillation ablations (lifetime); AF ablation within 3 months of enrollment; extensive scar in left atrium.
* Individual with valvular AF or AF due to a reversible cause
* Prior treatment with other devices for hypertension including but not limited to ROX Coupler, Mobius stent, and/or the CVRx barostimulator device.
* NYHA class IV congestive heart failure;
* Individual has renal artery anatomy that is ineligible for treatment (as determined by renal angiography);
* Main renal artery diameter \<3mm or \>8.0 mm
* Main renal treatable artery length \< 20 mm (length may include proximal branches)
* Presence of renal artery stenosis of any origin ≥30%
* Calcification in renal arteries
* Prior renal denervation procedure
* Presence of abnormal kidney tumors
* Renal artery aneurysm
* Pre-existing renal stent or history of renal artery angioplasty
* Pre-existing aortic stent or history of aortic aneurysm
* Fibromuscular disease of the renal arteries
* Iliac/femoral artery stenosis precluding insertion of the Paradise Catheter
* Individual has an estimated glomerular filtration rate (eGFR) of less than 40mL/min/1.73m2, using the MDRD calculation;
* Inability to undergo AF catheter ablation (e.g., presence of a left atrial thrombus, contraindication to all anticoagulation)
* Individual with known allergy to contrast medium not amendable to treatment.
* Life expectancy \<1 year for any medical condition
* Individual has experienced a myocardial infarction, unstable angina, cerebrovascular accident, or heart failure admission within 3 months of the baseline visit.
* Documented history of chronic active inflammatory bowel disorders such as Crohn's disease or ulcerative colitis.
* Female participants who are pregnant or nursing.
* Individual has known secondary hypertension.
* Individual has a single functioning kidney (either congenitally or iatrogenically).
* Individual has a known, unresolved history of drug use or alcohol dependency, lacks the ability to comprehend or follow instructions, or would be unlikely or unable to comply with study follow-up requirements.
* Patients concurrently enrolled in any other investigational drug or device trial that would interfere with the conduction of this protocol. DEVICE: Renal Denervation, DEVICE: Catheter Ablation
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
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Study Locations
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| Location | Contacts |
|---|---|
| Arrhythmia Research Group Jonesboro, Arkansas | Sarah Owens - (sowens@dnairresearch.com) |
| Christus Tyler, Texas | Adrian Maples - (adrian.maples@christushealth.org) |
| Henry Ford Health System Detroit, Michigan | Danielle Delmotte - (ddelmot2@hfhs.org) |
| Los Robles Medical Center Thousand Oaks, California | Marya Bengali - (Marya.Bengali@HCAhealthcare.com) |
| Mount Sinai Hospital New York, New York | Jeff Lam, MS - (jeff.lam@mountsinai.org) Betsy Ellsworth, MSN ANP - (betsy.ellsworth@mountsinai.org) |
| Trident Medical Center North Charleston, South Carolina | Molly Harper - (Molly.Harper@hcahealthcare.com) |
| UCSF San Francisco, California | Marialena Varympopioti - (MariaEleni.Varympopioti@ucsf.edu) |
| Virginia Commonwealth University Richmond, Virginia | Caleb Bridgwater - (Caleb.Bridgwater@vcuhealth.org) |
Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator (CARVTOP-ICD)
Mehmet Aktas, M.D. - Mehmet_Aktas@URMC.Rochester.edu
NCT06964464
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Inclusion Criteria:
* Age ≥ 18 years
* ICD implanted for primary prevention for HFrEF (either ICM or NICM) with remote monitoring capability
* Current treatment with metoprolol succinate and willing to switch to carvedilol
* LVEF \<50% during the past 12 months prior to consent
Exclusion Criteria:
* Unwilling or unable to follow the protocol
* Treatment with any other ßB than metoprolol succinate or no ßB treatment
* Known prior intolerance or contraindication to carvedilol
* Systolic blood pressure \<100 mmHg
* Enrollment in another clinical trial
* Inability or unwilling to consent DRUG: Metoprolol Succinate, DRUG: Carvedilol
Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death, Ventricular Arrhythmia, Implantable Cardioverter Defibrillator (ICD), Beta-blocker Therapy, Cardiomyopathy
arrhythmia, heart failure, ICD, implantable cardioverter defibrillator, ICD shock, carvedilol, metoprolol succinate, beta-blocker
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Show 13 locations
Study Locations
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| Location | Contacts |
|---|---|
| AdventHealth Redmond Rome, Georgia | Charles Jackson, MD - (charles.jackson.md@adventhealth.com) Kathy Jones - (kathy.d.jones@adventhealth.com) |
| AdventHealth Shawnee Mission Shawnee Mission, Kansas | Obadah Al Chekakie, MD - (MObadah.AlChekakie.MD@AdventHealth.com) Megan Kelly - (Megan.Kelly1@adventhealth.com) |
| Christus Trinity Mother Frances Health System Tyler, Texas | Joshua Rutland, MD - (joshua.rutland@christushealth.org) Carol Cushman - (carol.cushman@christushealth.org) |
| Creighton University Medical Center Omaha, Nebraska | Attila Roka, MD - (attilaroka@creighton.edu) Lois A. Rasmussen - (lois.rasmussen@commonspirit.org) |
| Health University of Utah Salt Lake City, Utah | Ravi Ranjan, MD - (ravi.ranjan@hsc.utah.edu) Audra Eaquinto - (audra.eaquinto@hsc.utah.edu) |
| Henry Ford Health System Detroit, Michigan | Waddah Maskoun, MD - (wmaskou1@hfhs.org) Briita Wanhala - (bwanhal1@hfhs.org) |
| HonorHealth Scottsdale, Arizona | Geoffrey Jao, MD - (gjao@honorhealth.com) Mary Futch Moyer - (mfutch@honorhealth.com) |
| New York-Presbyterian Brooklyn Methodist Hospital Brooklyn, New York | Gioia Turitto, MD - (git9006@nyp.org) Shana Hayes, M.S. - (cmc9055@nyp.org) |
| SUNY Downstate Brooklyn, New York | Adam S Budzikowski, MD - (abudzikowski@downstate.edu) Ann Harris - (ann.harris@downstate.edu) |
| University of Mossouri Columbia, Missouri | Brian Bostick, MD - (bostickb@health.missouri.edu) Charles Donigian - (donigianc@health.missouri.edu) |
| University of Rochester Medical Center Rochester, New York | Amole Ojo, MD - (amole_ojo@urmc.rochester.edu) Samantha Delmartino - (samantha_delmartino@urmc.rochester.edu) |
| University of Wisconsin Hospital and Clinics Madison, Wisconsin | Ryan Kipp, MD - (rtkipp@medicine.wisc.edu) Karen Olson - (kjolson@medicine.wisc.edu) |
| Virginia Commonwealth University Richmond, Virginia | Keyur Shah, MD - (keyur.shah@vcuhealth.org) Anna Baranova - (anna.baranova2@vcuhealth.org) |
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Medical Information - medinfo@eidostx.com
NCT06563895
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Key
Inclusion Criteria:
* Male or female ≥ 18 to ≤ 75 years of age inclusive.
* Participants must have an established genotype (hetero- or homozygosity) through a medically-indicated genetic test of a TTR gene variant that is known to be pathogenic or likely pathogenic (eg, V30M/p.V50M, V122I/p.V142I, T60A/p.T80A, or all other pathogenic TTR variants).
* Participant's age is within 10 years younger than or older than PADO.
Key Exclusion Criteria:
* Evidence of ATTR-CM or ATTR-PN.
* Current or past (within last 1 to 12 months, depending on specific agent) treatment with other TTR modifying therapies.
* Contraindication to or inability to undergo cardiac magnetic resonance testing.
* Major organ dysfunction, including: kidney disease, liver disease, heart disease (including cardiomyopathy), neuropathy
* Other diseases or conditions such has cancer within 5 years, untreated hyperthyroidism or hypothyroidism, type 1 diabetes, active hepatitis B or C, HIV.
* Major surgery within the past 3 months or planned during the next 12 months.
* Known hypersensitivity to acoramidis. DRUG: Acoramidis, DRUG: Placebo oral tablet
Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis, Cardiomyopathies, Heart Diseases, Polyneuropathies
Amyloidosis, ATTR-CM, ATTR-PN, Transthyretin, Amyloid, TTR
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Show 103 locations
Study Locations
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| Location | Contacts |
|---|---|
| AP-HP Hopital Bicetre Le Kremlin-Bicêtre, | |
| AP-HP Hopital Henri Mondor Paris, | |
| Aarhus University Hospital Aarhus, | |
| Azienda Ospedaliero Universitaria Policlinico Umberto I Roma, | |
| Azienda Ospedaliero-Universitaria Careggi Florence, | |
| Azienda Ospedaliero-Universitaria Sant'Andrea Rome, | |
| Azienda Ospedaliero-Universitaria di Bologna IRCCS Policlinico di S.Orsola Bologna, | |
| Boston University (BU) School of Medicine Boston, Massachusetts | |
| Brigham and Women's Hospital Boston, Massachusetts | |
| CAPED - Centro Avancado de Pesquisa, Estudos e Diagnostico Ribeirão Preto, | |
| CHU Bordeaux - Hopital Pellegrin Bordeaux, | |
| CHU de Fort de France Fort-de-France, | |
| CHU de Toulouse - Hopital Rangueil Toulouse, | |
| Cardiopulmonar da Bahia S.A. (Hospital Cardio Pulmonar) Salvador, | |
| Changhua Christian Hospital - Taiwan Changhua, | |
| Charite Universitaetsmedizin Berlin Berlin, | |
| Chu Rennes Rennes Cedes, | |
| Cleveland Clinic Cleveland, Ohio | |
| Cleveland Clinic Florida Weston, Florida | |
| Columbia University Medical Center New York, New York | |
| Duke University Medical Center Durham, North Carolina | |
| Emory University School Of Medicine Atlanta, Georgia | |
| Erasmus MC Rotterdam, South Holland | |
| Fiona Stanley Hospital Murdoch, Western Australia | |
| Fondazione IRCCS Policlinico San Matteo Pavia, | |
| Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore Rome, | |
| Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanità Pubblica - Ospedale San Cataldo Pisa, | |
| Fundacao Centro Medico de Campinas Campinas, | |
| General Hospital of Athens - Alexandra Athens, | |
| HIPPOKRATION General Hospital of Athens Athens, | |
| Henry Ford Health System Detroit, Michigan | |
| Hospital Britanico de Buenos Aires CABA, Buenos Aires | |
| Hospital Clinico Universitario de Salamanca Salamanca, | |
| Hospital Universitari de Bellvitge L'Hospitalet Del Llobregat, | |
| Hospital Universitario Juan Ramon Jimenez Huelva, | |
| Hospital Universitario Puerta de Hierro Majadahonda, | |
| Hospital Universitario Son Llatzer Palma de Mallorca, | |
| Hospital Universitario de A Coruna A Coruña, | |
| ICBA - Instituto Cardiovascular de Buenos Aires S.A. CABA, | |
| Inova Fairfax Hospital Falls Church, Virginia | |
| Instituto do Coracao (InCor) do Hospital das Clinicas da FMUSP Cerqueira César, | |
| John H. Stroger, Jr. Hospital of Cook County Chicago, Illinois | |
| Johns Hopkins University Baltimore, Maryland | |
| Kumamoto University Hospital Kumamoto, Kumamoto | |
| Laurelton Heart Specialists Rosedale, New York | |
| Maastricht University Medical Center Maastricht, | |
| Massachusetts General Hospital Boston, Massachusetts | |
| Mayo Clinic - Jacksonville Jacksonville, Florida | |
| Mayo Clinic - Rochester Rochester, Minnesota | |
| MedStar Washington Hospital Center - MedStar Heart and Vascular Institute Washington D.C., District of Columbia | |
| Medical University of South Carolina (MUSC) Charleston, South Carolina | |
| Mount Sinai Hospital New York, New York | |
| National Institute of Medical Sciences and Nutrition - Salvador Zubiran(INCMNSZ) Tlalpan, | |
| National Neuromuscular Research Institute Austin, Texas | |
| National Taiwan University Hospital Taipei, | |
| National University Hospital - National University Health System Singapore, | |
| New York University (NYU) School of Medicine - Langone Medical Center New York, New York | |
| Norrlands universitetssjukhus (University Hospital of Umea) Umeå, | |
| Oregon Health & Science University Portland, Oregon | |
| Penn Presbyterian Medical Center Philadelphia, Pennsylvania | |
| Princess Alexandra Hospital Woolloongabba, Queensland | |
| Prisma Health Cancer Institute Greenville, South Carolina | |
| Rutgers-Robert Wood Johnson Medical School New Brunswick, New Jersey | |
| Samsung Medical Center Seoul, | |
| Seoul National University Hospital Seoul, Seoul Teugbyeolsi | |
| Seoul St. Mary's Hospital Seoul, | |
| Severance Hospital, Yonsei University Health System Seoul, | |
| Shinshu University Hospital Nagano, Matsumoto, | |
| Singapore General Hospital Singapore, | |
| St Vincent's Hospital Sydney Darlinghurst, New South Wales | |
| St. Bartholomew's Hospital London, | |
| St. Luke's Hospital of Kansas City Kansas City, Missouri | |
| St. Michael's Hospital Toronto, Ontario | |
| Stanford University Stanford, California | |
| Taipei Veterans General Hospital Taipei, | |
| Tallaght University Hospital - The Adelaide and Meath Hospital Dublin, | |
| The Mater Misericordiae University Hospital Dublin, | |
| UZ Leuven Leuven, | |
| Unidade Local de Saude de Santa Maria EPE - Hospital de Santa Maria Lisbon, | |
| Unidade Local de Saude de Santo Antonio EPE - Hospital de Santo Antonio Porto, | |
| UniversitaetsKlinikum Heidelberg Heidelberg, | |
| Universitaetsmedizin der Johannes Gutenberg - Universitaet Mainz Mainz, | |
| Universitair Medisch Centrum Utrecht Utrecht, | |
| University College London Hospitals NHS Foundation Trust London, Greater London | |
| University Malaya Medical Centre (UMMC) Kuala Lumpur, | |
| University Medical Center Groningen Groningen, | |
| University of British Columbia Vancouver, British Columbia | |
| University of Calgary Calgary, Alberta | |
| University of California, Los Angeles (UCLA) - David Geffen School of Medicine Los Angeles, California | |
| University of California, San Diego (UCSD) - Medical Center La Jolla, California | |
| University of California, San Francisco (UCSF) San Francisco, California | |
| University of Chicago - Medical Center Chicago, Illinois | |
| University of Colorado Anschutz Aurora, Colorado | |
| University of Maryland Medical Center Baltimore, Maryland | |
| University of Pittsburgh Medical Center, Presbyterian Hospital Pittsburgh, Pennsylvania | |
| University of Texas Southwestern Dallas, Texas | |
| University of Utah Salt Lake City, Utah | |
| University of Washington Medical Center Seattle, Washington | |
| Virginia Commonwealth University Richmond, Virginia | |
| Washington University in St. Louis St Louis, Missouri | |
| Westmead Hospital Westmead, New South Wales | |
| Yale University School of Medicine - Section of Cardiology New Haven, Connecticut | |
| hospital Italiano de Buenos Aires CABA, |
His-Bundle Corrective Pacing in Heart Failure (HIS-CRT)
Ann Colasurdo - ann.colasurdo@heart.rochester.edu
NCT05265520
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Inclusion Criteria:
* Age 18 years or older (no upper age limit)
* Optimal medical therapy for heart failure by current guidelines
* Class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following:
* New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 150 ms (IIb); OR
* NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa); OR
* NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb)
Exclusion Criteria:
* Unable to obtain most recent imaging data from echocardiogram within 1 year prior to date of randomization
* Left bundle branch block (LBBB) or intraventricular conduction delay (IVCD) ECG morphology
* Unable or unwilling to follow study protocol
* Less than 12 months life expectancy at consent
* Pregnancy or planned pregnancy during duration of the study
* On heart transplant list or likely to undergo heart transplant PROCEDURE: His-CRT implantation, PROCEDURE: BIV-CRT implantation
Right Bundle-Branch Block, Heart Failure, His-bundle Pacing, Cardiac Resynchronization Therapy
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Show 14 locations
Study Locations
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| Location | Contacts |
|---|---|
| Cedars-Sinai Medical Center Los Angeles, California | |
| Geisinger Wyoming Valley Wilkes-Barre, Pennsylvania | |
| Mission Health Asheville, North Carolina | |
| Mount Sinai Hospital New York, New York | |
| Northwestern Memorial Hospital Chicago, Illinois | |
| Rush University Medical Center Chicago, Illinois | |
| University of Arizona Tucson, Arizona | |
| University of Chicago Chicago, Illinois | |
| University of Pennsylvania Philadelphia, Pennsylvania | |
| University of South Florida Tampa, Florida | |
| University of Vermont Burlington, Vermont | |
| Valley Health System Ridgewood, New Jersey | |
| Virginia Commonwealth University Richmond, Virginia | |
| Weill Cornell Medical College New York, New York |
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity (HF-POLARIS)
Novo Nordisk - clinicaltrials@novonordisk.com
NCT07567001
Show full eligibility criteria
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Inclusion Criteria:
* Body Mass Index (BMI) greater than or equal to (\>=) 30 kilograms per square metre (kg/m\^2) at screening.
* Diagnosis of HF with New York Heart Association (NYHA) class II-IV and in stable condition at screening, at the discretion of the investigator.
For participants with Type 2 Diabetes (T2D) at screening:
\- Diagnosed with T2D \>= 30 days before screening.
Exclusion Criteria:
* MI, stroke, unstable angina pectoris or worsening HF leading to either hospitalization or intravenous loop diuretics within 30 days prior to the day of screening and until randomization.
* HF due to infiltrative cardiomyopathy (e.g., sarcoid, amyloid), arrhythmogenic right ventricular cardiomyopathy, Takutsubo cardiomyopathy, Chagas cardiomyopathy, genetic hypertrophic cardiomyopathy or obstructive cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, or uncorrected primary valve disease of moderate or severe degree.
* Severe pulmonary disease including primary pulmonary hypertension, chronic pulmonary embolism, or severe chronic obstructive pulmonary disease (COPD) defined as:
* requiring home oxygen; or - ongoing oral corticosteroid therapy; or - hospital for COPD Exacerbation within 12 months prior to screening.
* Any other condition judged by the investigator to be the cause of HF symptoms (e.g., anaemia, hypothyroidism).
Glycaemia-related:
* History of type 1 diabetes.
* Participant with diabetic retinopathy or maculopathy who received treatment with retinal photocoagulation, vitrectomy or anti-Vascular Endothelial Growth Factor (anti-VEGF) within 180 days before screening or who, at the time of screening, are expected to require treatment within 180 days after screening. Diabetic retinopathy or maculopathy must be verified by an eye examination performed within 90 days before screening or in the period between screening and randomization. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
* Glycated haemoglobin (HbA1c) greater than (\>) 10 percent (%) (86 \[millimoles per mole\] mmol/mol) as measured by local or central laboratory at screening. DRUG: NNC0487-0111, DRUG: Placebo
Obesity, Heart Failure
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Show 839 locations
Study Locations
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| Location | Contacts |
|---|---|
| "AHEPA" University General Hospital of Thessaloniki Thessaloniki, | |
| "Hygeia" General Hospital of Athens Athens, | |
| 'G. Gennimatas' General Hospital of Athens - Cardiology Department Athens, | |
| 'Ippokrateio' General Hospital of Thessaloniki Thessaloniki, | |
| 251 Air Force General Hospital - Department of Endocrinology & Diabetes Athens, | |
| 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu Wroclaw, | |
| AHEPA General University Hospital Thessaloniki, | |
| AIPSCMC - Dr. Nikolay Iliev EOOD Pleven, | |
| AIPSMCIDC - Dr. Georgi Nedyalkov EOOD Plovdiv, | |
| AOU Bologna - Malpighi - Dipartimento Medicina Interna Bologna, Emilia-Romagna | |
| AOU Federico II Di Napoli - DAI di Medicina Interna e della Complessità Clinica Naples, Campania | |
| AOU Perugia - Santa Maria della Misericordia - S. C. Medicina Interna Perugia, Umbria | |
| AOU Sassari - UOC Cardiologica Clinica ed Interventistica Sassari, | |
| APHP - HOPITAL BICETRE_Service de Cardiologie Le Kremlin-Bicêtre, | |
| ASSL Sette Laghi - Ospedale Galmarini di Tradate Varese, Lombardy | |
| ASST Papa Giovanni XXIII - Cardiologia 1 Bergamo, Lombardy | |
| Accellacare Wilmington Wilmington, North Carolina | |
| Acibadem City Clinic UMHAT EOOD, Cardiology Sofia, | |
| Adana Şehir Eğitim ve Araştırma Hastanesi Adana, | |
| Adana Şehir Eğitim ve Araştırma Hastanesi-Dahiliye Yuregir/Adana, | |
| Adrian Costa Clinical Trials Centre Geelong, Victoria | |
| Advanced Cardiology LLC - Hackettstown Hackettstown, New Jersey | |
| Advanced Cardiovascular, LLC Alexander City, Alabama | |
| Advanced Medical Research Maumee, Ohio | |
| Advara HeartCare Joondalup Joondalup, Western Australia | |
| Advara HeartCare Leabrook Leabrook, South Australia | |
| Advara HeartCare Mulgrave Mulgrave, Victoria | |
| Adventist Healthcare Shady Grove Medical Center Rockville, Maryland | |
| Aesculap Ambulance s.r.o. Dolní Břežany, | |
| Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji Afyonkarahisar, | |
| Aintree University Hospital Liverpool, | |
| Ajou University Hospital_Cardiology Suwon, Gyeonggi-do | |
| Akdeniz Üniversitesi Hastanesi-Kardiyoloji Antalya, | |
| Al-Zoebi Wermsdorf, | |
| Alexandra General Hospital, Therapeutic Clinic Athens, | |
| All India Institute of Medical Sciences (AIIMS) New Delhi, | |
| All India Institute of Medical Sciences (AIIMS), Bhubaneswar Bhubaneswar, Odisha | |
| All India Institute of Medical Sciences (AIIMS), Nagpur Nagpur, Maharashtra | |
| Alrijne Leiderdorp - Cardiologie Leiderdorp, | |
| American Clinical Trials, LLC Acworth, Georgia | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| American Heart of Poland S.A. Kędzierzyn-Koźle, | |
| Amicis Centers of Clinical Research St Louis, Missouri | |
| Amicis Research Center Northridge, California | |
| Amicis Research Center Northridge, California | |
| Amphia Ziekenhuis Breda, | |
| Amrita Institute of Medical Sciences Kochi, Kerala | |
| AmsterdamUMC AMC Amsterdam, | |
| Anderson Medical Group Ft. Washington, Maryland | |
| AngioCor Blumenau Blumenau, Santa Catarina | |
| Ankara Bilkent Şehir Hastanesi-Dahiliye Ankara, | |
| Ankara Bilkent Şehir Hastanesi-Kardiyoloji Ankara, | |
| Ankara Etlik Şehir Hastanesi- Kardiyoloji Yenimahalle/Ankara, | |
| Antalya Eğitim ve Araştırma Hastanesi- Kardiyoloji Muratpasa/ Antalya, | |
| Arcispedale S. Maria Nuova - U.O.C. Cardiologia Reggio Emilia, Emilia-Romagna | |
| Arcispedale Sant'Anna (Cona) - Dipartimento Interaziendale Cardio-toraco-vascolare Ferrara, Emilia-Romagna | |
| Arizona Research Center Phoenix, Arizona | |
| Arkansas Health Group Little Rock, Arkansas | |
| Arneja Heart & Multispeciality Hospital Nagpur, Maharashtra | |
| Arrow Clinical Trials Daytona Beach, Florida | |
| Asan Medical Center_Cardiology Seoul, | |
| Ascension Saint Agnes Heart Ca Baltimore, Maryland | |
| Asha Clinical Rsch-Munster, LLC Hammond, Indiana | |
| Asklepieion General Hospital - Cardiology Clinic Athens/Voula, | |
| Asklepios Klinik Langen - Medizinische Klinik I Langen, | |
| Associacao Beneficente Siria - HCOR São Paulo, São Paulo | |
| Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista Bragança Paulista, São Paulo | |
| Assuta Ashdod MC - The Institute of Cardiology Ashdod, | |
| Aster Medcity Kochi, Kerala | |
| Atatürk Üniversitesi Araştırma Hastanesi-Kardiyoloji Yakutiye / Erzurum, | |
| Athens Medical Center S.A (Iatriko Athinon) - Cardiology Clinic Athens, | |
| Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department Peristeri, | |
| Athens Medical Center S.A., European Interbalkan Medical Center - Department of Internal Medicine Thessaloniki, | |
| Atlanta Center for Clinical Research_Atlanta Atlanta, Georgia | |
| Atlanta Heart Specialists, LLC Tucker, Georgia | |
| AtlantiCare Regional Medical Center Pomona, New Jersey | |
| Augustinerinnen KHs - Cellitinnen KH Köln Cologne, | |
| Aultman Hospital Canton, Ohio | |
| Aurora St. Luke's Medi Ctr Milwaukee, Wisconsin | |
| Austin Heart San Marcos, Texas | |
| Austin Heart San Marcos, Texas | |
| Azienda Ospedaliera Padova - UOC Clinica Medica 3 Padova, Veneto | |
| Azienda Ospedaliera Policlinico Universitario Tor Vergata - UOC Cardiologia Rome, Lazio | |
| Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone - U.O. Cardiologia Palermo, Sicily | |
| Azienda Ospedaliero - Universitaria Sant'Andrea - UOC Medicina interna Rome, Lazio | |
| Azienda Ospedaliero Universitaria Pisana - U.O. Medicina 1 Pisa, Tuscany | |
| Azienda Ospedaliero-Universitaria Senese - Dipartimento Cardio-toraco-vascolare Siena, Tuscany | |
| Azienda Ospedaliero-Universitaria Senese - Dipartimento Cardio-toraco-vascolare Siena, Tuscany | |
| Baker-HeartWest - Hoppers Crossing Hoppers Crossing, Victoria | |
| Balad Hlth Sys-Welmont CardCVA Greeneville, Tennessee | |
| Balticmed Świnoujście Sp. z o. o. Świnoujście, | |
| Baotou City Central Hospital-Cardiology Baotou, Inner Mongolia | |
| Barnet Hospital - Cardiology Department Barnet, | |
| Batra Hospital and Medical Research Center New Delhi, National Capital Territory of Delhi | |
| BayCare Health System Clearwater, Florida | |
| Baylor Scott & White Health Temple, Texas | |
| Baylor Scott & White Health Temple, Texas | |
| Baylor Scott & White Health Temple, Texas | |
| Baylor Scott & White Res Inst Plano, Texas | |
| Bella Vita Clinical Research Cape Town, Western Cape | |
| Biopharma Informatic, LLC McAllen, Texas | |
| Blue Coast Research Center Vista, California | |
| Bnai Zion MC - Department of Cardiology Haifa, | |
| Bravis Zkh Roosendaal Roosendaal, | |
| Broward Research Ctr. Miami Beach, Florida | |
| Broward Research Ctr. Miami Beach, Florida | |
| Bryan Heart Lincoln, Nebraska | |
| Bursa Yüksek İhtisas Eğitim ve Araştırma Merkezi-Kardiyoloji Bursa, | |
| C.I.C. Joliette Saint-Charles-Borromée, Quebec | |
| CAICI Rosario, | |
| CAPED - Centro Avançado de Pesquisa, Estudos e Diagnósticos Ribeirão Preto, São Paulo | |
| CC LIFE s.r.o. Brno, | |
| CCECB _Cabinet de Cardiologie ALDAPA Bayonne, | |
| CCIH-Consultoria em Controle de Infecção Hospitalar Ltda Belo Horizonte, Minas Gerais | |
| CEDIC Centro de Investigación Clínica CABA, | |
| CEDIR - Centro de diagnóstico y rehabilitación Santa Fe Santa Fe, | |
| CEMEDIC CABA, Buenos Aires | |
| CENTRE HOSPITALIER DE CHOLET_Service de Cardiologie Cholet, | |
| CENTRE HOSPITALIER DE VERSAILLES-HOPITAL ANDRE MIGNOT_Service de Cardiologie Le Chesnay, | |
| CH LA ROCHELLE - Service de Cardiologie La Rochelle, | |
| CHI Franciscan Research Center Tacoma, Washington | |
| CHI TOULON - HOPITAL SAINTE MUSSE_Service de Cardiologie Toulon, | |
| CHRU BREST - HOPITAL DE LA CAVALE BLANCHE_Service de cardiologie Brest, | |
| CHRU NANCY - HOPITAL BRABOIS_Service de Cardiologie Vandœuvre-lès-Nancy, | |
| CHRU TOURS - HOPITAL TROUSSEAU - Service de Cardiologie Chambray-lès-Tours, | |
| CHU NANTES - HOPITAL NORD LAENNEC_Service d'Endocrinologie-Diabétologie-Nutrition Saint-Herblain, | |
| CHU NIMES - HOPITAL CAREMEAU_Service de Cardiologie Nîmes, | |
| CHU de Quebec-Uni Laval-Hotel Québec, | |
| CHUM-Hosp de Univ Montreal Montreal, Quebec | |
| CIMAB SA de CV Torreón, Coahuila | |
| CIPES - Centro Internacional de Pesquisa Clínica LTDA São José dos Campos, São Paulo | |
| CISSS BAS ST-LAURENT, HOPITAL regional DE RIMOUSKI Rimouski, Quebec | |
| CIUSSS du Saguenay-Lac-St-Jean Chicoutimi, Quebec | |
| CLINIQUE DU MILLENAIRE_Service de Cardiologie Interventionelle Montpellier, | |
| CMC Cardiología Sociedad Simple San Miguel de Tucumán, | |
| CPQuali Pesquisa Clinica Ltda São Paulo, São Paulo | |
| CPS Research Waterloo, Ontario | |
| California Heart Specialist Huntington Beach, California | |
| Canberra Hospital - Clinical Trials Unit Canberra, Australian Capital Territory | |
| Capital Cardiology Associates_Albany Albany, New York | |
| Card Specialists of Willowbrook Houston, Texas | |
| CardiaMet Ciudad Autonoma de Buenos Aires, Buenos Aires | |
| Cardiac Clinical Research Unit, University of Cape Town Cape Town, Western Cape | |
| Cardiac Institute for Research at Queen's - CIRQ Kingston, Ontario | |
| Cardiac Vascular Sentral Kuala Lumpur Kuala Lumpur, Kuala Lumpur | |
| Cardio Health Clinical Trials Kitchener, | |
| Cardio Innovation & Resch Ctr Long Beach, California | |
| Cardio Metabolic Institute Somerset, New Jersey | |
| Cardio Research & Education Foundation Wausau, Wisconsin | |
| Cardio Research of S. Cal Beverly Hills, California | |
| Cardio Research s.r.o. Zlín, | |
| Cardio and Vascular Assoc-CAVA Bloomfield Hills, Michigan | |
| CardioConsil GmbH Rostock, | |
| Cardiologicum Dresden und Pirna - MVZ "Am Felsenkeller" (Dresden) Dresden, | |
| Cardiología Hospital J. M. Ramos Mejia Buenos Aires, | |
| Cardiología Palermo City of Buenos Aires, Buenos Aires | |
| Cardiovascular Consultants of South Georgia Thomasville, Georgia | |
| Cardiovascular Institute of Orlando Orlando, Florida | |
| Cardiovascular Institute of the South Opelousas, Louisiana | |
| Cardiovascular Institute of the South Opelousas, Louisiana | |
| Care Access Research Thousand Oaks, California | |
| Care United Research, LLC Forney, Texas | |
| Carient Heart and Vascular Manassas, Virginia | |
| Catharina Zkh Eindhoven - Cardiologie Eindhoven, | |
| Cbk Med Clinic Sp. z o.o. Płock, Masovian Voivodeship | |
| Centro Cardiovascular Salta Salta, | |
| Centro Medico Capital La Plata, Buenos Aires, | |
| Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli Buenos Aires, | |
| Centro Médico CIMEL Lanús Este, Buenos Aires | |
| Centro Médico Luquez Córdoba, | |
| Centro de Atención al Diabético Actopan (CAD) Actopan, Hidalgo | |
| Centro de Atención e Investigación Cardiovascular del Potosi (CICAP) San Luis Potosí City, | |
| Centro de Investigaciones Clinica Baigorria Santa Fe, | |
| Centro de Investigaciones Clinicas del Litoral Santa Fe, | |
| Centro de Investigaciones Metabólicas Capital Federal, Buenos Aires | |
| Centro de Investigación Integral MEDIVEST Chihuahua City, | |
| Centro de Investigación y Control Metabólico S. C. San Nicolás de los Garza, Nuevo León | |
| Centro de Pesquisa Silvestre Santé Rio Branco, Acre | |
| Centro de Pesquisas Clínicas Dr. Marco Mota LTDA Maceió, Alagoa | |
| Centrum Medyczne "Hipokrates" s.c. Elżbieta i Grzegorz Grześk Bydgoszcz, | |
| Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j. Bydgoszcz, | |
| Centrum Medyczne Komorniki Sp. z o.o. Komorniki, | |
| Centrum Medyczne MBB-MED Marta Blach-Burek Libiąż, | |
| Centrum Medyczne MBB-MED Marta Blach-Burek Libiąż, | |
| Centrum Medyczne Ogrodowa Sp. z o.o. Lowicz, | |
| Chambersburg Hospital Chambersburg, Pennsylvania | |
| Chang Gung Memorial Hospital - Kaohsiung Branch Kaohsiung City, | |
| Chang Gung Memorial Hospital, Linkou Taoyuan County, | |
| Changsha Central Hospital-Cardiovascular Medicine Changsha, Hunan | |
| Changzhou No.2 People's Hospital-Cardiology Changzhou, Jiangsu | |
| Charité - Campus Virchow-Klinikum - Kardiologie, Angiologie und Intensivmedizin (CRU) Berlin, | |
| Chesterfield Royal Hospital Chesterfield, | |
| Chicago Clinical Research Institute INC Orland Park, Illinois | |
| Chicago Clinical Research Institute INC Orland Park, Illinois | |
| Chicago Medical Research LLC Hazel Crest, Illinois | |
| China-Japan Union Hospital of Jilin University-Cardiology Changchun, Jilin | |
| Chonnam National University Hospital_Cardiology Gwangju, | |
| Chungnam National University Hospital_Cardiology Daejeon, | |
| Circulate Cardiac and Vascular Centre Burlington, Ontario | |
| Clalit HMO Holon - Heart Institute Holon, | |
| Clearwater Cardiovascular Consultants Safety Harbor, Florida | |
| Clindove Research Brooklyn, New York | |
| Clinical Medical Research Sp. z o.o. Katowice, | |
| Clinical Research Consultants, JCCT Co Kansas City, Missouri | |
| Clinical Research Institute of South Africa KwaDukuza, KwaZulu-Natal | |
| Clinical Trial Systems (CTC) Pretoria, Gauteng | |
| Clinical Trials Network Helderberg (Pty) Ltd Somerset West, Western Cape | |
| Clinique Saint Augustin Bordeaux, | |
| Clinresco Centres (Pty) Ltd Kempton Park, Gauteng | |
| Clinstile S.A. de C.V. Col Roma Norte, Mexico City | |
| Clínica Privada Velez Sarsfield Córdoba, | |
| Colorado Heart and Vascular PC Golden, Colorado | |
| Columbia University Medical Center_New York New York, New York | |
| Complejo Hospitalario Universitario A Coruna A Coruña, | |
| Conquest Research Vienna, Virginia | |
| Consultorio 1020 Hospital Angeles Xalapa Xalapa, Veracruz | |
| Consultorio Dr. Eduardo Chuquiure Tlalpan, Mexico City | |
| Consultorio Privado Dr Gabriel Arturo Ramos Guadalajara, Jalisco | |
| Consultorio Privado Dr. Francisco Padilla Guadalajara, Jalisco | |
| Corcare Cardiovascular Research Scarborough Village, Ontario | |
| Core Research Group Brisbane, | |
| Corewell Health Grand Rapids, Michigan | |
| Craigavon Area Hospital - Cardiovascular Research Unit Craigavon, | |
| Crescent Hospital And Heart Centre Nagpur, Maharashtra | |
| Curnew Medicine Professional Corporation Hamilton, Ontario | |
| DAI Scienze Mediche - UOC Medicina Interna Angiologia e Malattie Aterosclerotiche Messina, Sicily | |
| DBC Research - Pembroke Pines Pembroke Pines, Florida | |
| DCC 1 - Lom EOOD Lom, | |
| DCC Aleksandrovska EOOD Sofia, | |
| DCC Convex EOOD Sofia, | |
| Dallas Heart and Vascular Duncanville, Texas | |
| David Turbay, MD, PLLC El Paso, Texas | |
| Dayanand Medical College & Hospital Ludhiana, Punjab | |
| Deenanath Mangeshkar Hospital & Research Centre Pune, | |
| Derriford Hospital Plymouth, | |
| Desert Oasis Healthcare Palm Springs, California | |
| Diabetes Heart Research Centre Toronto, Ontario | |
| Diakonessenhuis Utrecht - Cardiologie Utrecht, | |
| Diex Recherche Sherbrooke Sherbrooke, Quebec | |
| Diex Recherche Trois-Rivieres Trois-Rivières, Quebec | |
| Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi-Kardiyoloji Izmir, | |
| Dorset County Hospital Dorchester, Dorset | |
| Doylestown Heath cardiology Doylestown, Pennsylvania | |
| Dr A Jacovides and Partners Inc Midrand, Gauteng | |
| Dr Hendrik Snyman's Practice Mossel Bay, Western Cape | |
| Dr IO Ebrahim Inc Pretoria, Gauteng | |
| Dr MT Makhomisane Inc Polokwane, | |
| Dr Pillay's Rooms Durban, KwaZulu-Natal | |
| Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji Istanbul, | |
| Duke University Durham, North Carolina | |
| EKAMED sp. z o.o. Lublin, Lublin Voivodeship | |
| Eagle Clinical Research Chicago, Illinois | |
| East Atlanta Cardiology Conyers, Georgia | |
| East Rand Physicians Clinical Research Division (Pty) Ltd Benoni, Gauteng | |
| East Texas Cardiology PA Houston, Texas | |
| Eastbourne Distirct General Hospital - Cardiology Eastbourne, | |
| Eastern Shore Rsrch Inst, LLC Fairhope, Alabama | |
| Edumed s.r.o. Broumov, Hradec Králové Region | |
| Edumed s.r.o. Broumov, Hradec Králové Region | |
| Elkerliek Ziekenhuis - Cardiologie Helmond, | |
| Empire Clin. Research Pomona, California | |
| Endolife Specialty Hospitals Guntur, Andhra Pradesh | |
| Erciyes Üniversitesi Hastanesi- Kardiyoloji Kayseri, | |
| Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji Eskişehir, | |
| Eskişehir Şehir Hastanesi- Kardiyoloji Eskişehir, | |
| Eurolatino Medical Research Center Uberlândia, Minas Gerais | |
| FOMAT Medical Research Santa Maria, California | |
| Facharztzentrum Dresden Betriebsgesellschaft mbH Dresden, | |
| Fakultni nemocnice Brno Brno, | |
| Fakultni nemocnice Olomouc Olomouc, | |
| Fakultni nemocnice u sv. Anny v Brne Brno, | |
| Flinders Medical Centre - Cardiology Department Bedford Park, South Australia | |
| Flourish Research Bowie Bowie, Maryland | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Dipartimento di Scienze Cardiovascolari Rome, Lazio | |
| Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann Witten, | |
| Fortis Hospital, Mohali Mohali, Punjab | |
| Fortis Memorial Research Institute _Gurgaon Gurugram, Haryana | |
| Franciscus Gasthuis en Vlietland - Cardiologie Rotterdam, | |
| Frederiksberg Hospital - Hjertemedicinsk afdeling Y Frederiksberg, | |
| Fukuoka Wajiro Hospital_Cardiology Fukuoka-shi, Fukuoka, | |
| Fukuokaken Saiseikai Futsukaichi Hospital_Cardiovascular Medicine Chikushino-shi, Fukuoka, | |
| Fundacion Respirar Buenos Aires, | |
| Fundação Faculdade Regional de Medicina de São José do Rio Preto São José do Rio Preto, | |
| Future Life Clinical Trials Miami, Florida | |
| Futuremeds Sp. z o.o. Olsztyn, | |
| Fırat Üniversitesi Hastanesi- Kardiyoloji Merkez/elaziğ, | |
| G B Pant Institute of Postgraduate Medical Education and Research New Delhi, National Capital Territory of Delhi | |
| G&J Research San Diego, California | |
| G.A. Research Associates Ltd. Moncton, New Brunswick | |
| Gachon University Gil Medical Center_Cardiology Incheon, | |
| Galaxy Life Care Services Pvt. Ltd Varanasi, Uttar Pradesh | |
| Gangnam Severance Hospital_Cardiology Seoul, | |
| Gelderse Vallei - Cardiologie Ede, | |
| Gemeinschaftspraxis Faghih-Friedrichs-Zühlke Essen, | |
| Gemeinschaftspraxis Melcherstätte - Dr. L. Pohlmeier, T. Drescher Stuhr, | |
| General Hospital Venizeleio-Pananeio - Cardiology department Heraklion, | |
| General Hospital of Athens "Elpis" - Cardiology Department Ampelokipoi/Athens, | |
| General Hospital of Athens "Laiko" Goudi/Athens, | |
| General Hospital of Chalkida - Cardiology department Chalcis, | |
| General Hospital of Chios "Skilitsio" - Cardiology Clinic Chios, | |
| General Hospital of Kalamata - Cardiology Department Kalamata, | |
| General Hospital of Thessaloniki "G.Papanikolaou" Thessaloniki, | |
| George Eliot Hospital Nuneaton, Warwickshire | |
| Gesundheitscentrum Mainz (Regner / Schmitt) Mainz, | |
| Glan Clwyd Hospital - North Wales Cardiac Centre Rhyl, Denbighshire | |
| Glenfield Hospital - Cardiovascular Research Leicester, | |
| Glenny Corp. S.A CABA, | |
| Government Siddhartha Medical College & Government General Hospital, Vijayawada Vijayawada, Andhra Pradesh | |
| Grace Research, LLC Bossier City, Louisiana | |
| Grace Research, LLC_Shreveport Shreveport, Louisiana | |
| Groene Hart Zkh Gouda - Cardiologie Gouda, | |
| Guangdong Provincial People's Hospital-Cardiovascular Guangzhou, Guangdong | |
| Guardian Research Org LLC Winter Park, Florida | |
| Gunma University Hospital_Cardiovascular Medicine Maebashi-shi, Gunma, | |
| Gyncentrum Sp. z o. o. Katowice, | |
| Gülhane Eğitim ve Araştırma Hastanesi- Kardiyoloji Keçiören/Ankara, | |
| H Virgen del Camino_Sanlúcar_Medicina Interna Sanlúcar de Barrameda, | |
| H. Fundación Alcorcón_Cardiología Alcorcón, | |
| H.Sant Joan Despí_Dto. Cardiología Sant Joan Despí, Catalonia | |
| HCL-HOPITAL LYON SUD_Service d'Endocrinologie-Diabète-Nutrition Pierre-Bénite, | |
| Hadassah Ein Karam MC - Cardio Department Jerusalem, | |
| Haemek MC - Research Unit of Internal Medicine C Afula, | |
| Hallym University Sacred Heart Hospital_Cardiology Anyang-si, Gyeonggi-do | |
| Halton Healthcare Oakville, Ontario | |
| Hanyang university seoul hospital_Cardiology Seoul, | |
| Hawthorne Health Diamondhead, Mississippi | |
| Hawthorne Health NC Concord, North Carolina | |
| Hayama Heart Center_Cardiology Miura-gun, Kanagawa, | |
| Healthworld hospitals Durgapur, West Bengal | |
| Heart House - Sewell Sewell, New Jersey | |
| Heart House - Vineland Elmer, New Jersey | |
| Heart of Australia Chelmer, Queensland | |
| Helderberg Research Institute Cape Town, Western Cape | |
| Henry Ford Health System Detroit, Michigan | |
| Herlev Hospital - Afdeling for Hjertesygdomme, Forskning 1 Herlev, | |
| Herz- und Diabeteszentrum NRW - Bad Oeynhausen Bad Oeynhausen, | |
| Herz-Kreislauf-Zentrum Klinikum Hersfeld-Rotenburg GmbH - Zentrum für Klinische Forschung Rotenburg A. D. Fulda, | |
| Herz-Lungen-Zentrum Weyhe-Leeste Weyhe, | |
| Higashi Takarazuka Satoh Hospital_Cardiology Hyōgo, | |
| Higashiosaka City Medical Center_Cardiovascular Medicine Higashiosaka-shi, Osaka, | |
| High Desert Heart and Vascular PLLC Meridian, Idaho | |
| Hillel Yaffe MC - Cardiology Department Hadera, | |
| Holbæk Sygehus - Forskningsenheden, Medicinsk Afdeling, afs. 44-4 Holbæk, | |
| Honor Health Phoenix, Arizona | |
| Hope Clin Res & Wellness Conyers, Georgia | |
| Hope Research Network Virginia Gardens, Florida | |
| Horizon Research Group of Opelousas, LLC Eunice, Louisiana | |
| Hosp. Comarcal de Antequera_Medicina Interna Antequera, | |
| Hosp. U Gran Canaria Dr. Negrín_Cardiologia Las Palmas de Gran Canaria, | |
| Hosp. Univ. de Jaén_Cardiología Jaén, | |
| Hosp. Virgen de las Montañas_Medicina Interna Villamartín, | |
| Hospital 12 de Octubre Madrid, | |
| Hospital Alemão Oswaldo Cruz São Paulo, | |
| Hospital Canselor Tuanku Muhriz UKM Cheras, Kuala Lumpur | |
| Hospital Clinico Universitario de Valencia Valencia, | |
| Hospital De La Santa Creu I Sant Pau Barcelona, | |
| Hospital Espanol De Mendoza Godoy Cruz, Mendoza, Mendoza Province | |
| Hospital General de Mexico (HGM) Cuauhtémoc, Mexico City | |
| Hospital Germans Trias I Pujol Barcelona, | |
| Hospital Kuala Lumpur Kuala Lumpur, | |
| Hospital Miri Miri, Sarawak | |
| Hospital Pakar Sultanah Fatimah Muar town, Johor | |
| Hospital Ramón.y Cajal_Med. Interna Madrid, | |
| Hospital Serdang Kajang, Selangor | |
| Hospital Sultanah Aminah Johor Bahru, Johor | |
| Hospital Sultanah Bahiyah Alor Star, Kedah | |
| Hospital Taiping Taiping, Perak | |
| Hospital Tengku Ampuan Afzan Kuantan, Pahang | |
| Hospital Tuanku Fauziah Kangar, Perlis, | |
| Hospital Univ. La Luz_Cardiología Madrid, | |
| Hospital Univ. Virgen de la Arrixaca El Palmar, | |
| Hospital Univ. de Gerona Doctor Josep Trueta Girona, | |
| Hospital Universitario Austral - Instituto de Cardiologia Pilar, Buenos Aires | |
| Hospital Universitario Dr. José Eleuterio González_Monterrey Monterrey, Nuevo León | |
| Hospital Universitario La Paz Madrid, | |
| Hospital Universitario Lucus Augusti Lugo, | |
| Hospital Universitario Puerta de Hierro Majadahonda Majadahonda, | |
| Hospital Universitario Virgen de Valme Seville, | |
| Hospital Universitario Virgen de las Nieves Granada, | |
| Hospital Universitario Virgen del Rocio Seville, | |
| Hospital Universitario y Politécnico La Fe Valencia, Valencia | |
| Hospital Universiti Sains Malaysia Kota Bharu, Kelantan | |
| Hospital Vall d'Hebron Barcelona, | |
| Hospital Zambrano Hellion TecSalud Monterrey, Nuevo León | |
| Hospital de Basurto Bilbao, | |
| Hospital de Clínicas da Universidade Federal de Goiânia Goiânia/GO, | |
| Hospital de Clínicas de Porto Alegre Porto Alegre, | |
| Hospital de Manises Manises, | |
| Hvidovre Hospital Hjertemedicinsk Hvidovre, | |
| Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology Himeji-shi, Hyogo, | |
| IAPES Pesquisa Clínica - Rede AME Saúde Recife, Pernambuco | |
| ICM - Instituto do Coração de Marília Marília/SP, | |
| ICOT Istituto Marco Pasquali - UOC Cardiologia Latina, Lazio | |
| IMA Research Lenoir, North Carolina | |
| INECO Neurociencias Oroño Rosario, | |
| IRCCS Humanitas - UOC Cardiologia Rozzano, Milano | |
| IRCCS Ospedale Policlinico San Martino - U.O. Clinica di Malattie dell'Apparato Cardiovascolare e UTIC Genoa, Liguria | |
| IRCCS Policlinico San Matteo - S.C. Cardiologia Pavia, Lombardy | |
| IRCCS San Raffaele - Dipartimento area Cardiorespiratoria Rome, Lazio | |
| IUCPQ - Universite Laval Québec, | |
| Iaso Thessalia General Clinic Private Obstetrics S.A. - Cardiology Clinic Larissa, | |
| Iatros International Bloemfontein, Free State | |
| Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman Gdynia, Pomeranian Voivodeship | |
| Indiana University Health Methodist Hospital Indianapolis, Indiana | |
| Infinite Clinical Research Miami, Florida | |
| Inha University Hospital_Cardiology Incheon, | |
| Innera s.r.o. Benešov, | |
| InnoMed Clinical Trial Centre Cape Town, Western Cape | |
| Inpatient Research Clinic LLC Miami Lakes, Florida | |
| Inpatient Research Clinic LLC Miami Lakes, Florida | |
| Institut klinicke a experimentalni mediciny Prague, | |
| Instituto Cardiovascular de León S.C. León, Guanajuato | |
| Instituto Dante Pazzanese de Cardiologia São Paulo, São Paulo | |
| Instituto Especialidades de la Salud Rosario Rosario, Santa Fe Province | |
| Instituto Medico Quirurgico San Rafael A Coruña, | |
| Instituto de Investigaciones Clinicas San Nicolas San Nicolás, | |
| Instituto de Investigaciones Clínicas Córdoba Córdoba, | |
| Instituto de Investigaciones Clínicas Rosario Rosario, | |
| Instituto de Investigaciones de Patologías Respiratorias San Miguel de Tucumán, | |
| Instituto de Moléstias Cardiovasculares de Tatuí Ltda Tatuí, São Paulo | |
| Instituto de Pesquisa Clinica de Campinas Campinas, | |
| Instituto do Coração - HCFMUSP São Paulo, São Paulo | |
| Intercard Spolka z ograniczona odpowiedzialnoscia Krosno, | |
| Intercoastal Medical Group Sarasota, Florida | |
| Intermountain Heart & Vascular Denver, Colorado | |
| Intermountain Medical Center Murray, Utah | |
| Internal Medicine Clin Trials Monterrey, Nuevo León | |
| Interventional Cardiology Medical Group West Hills, California | |
| InvivoCure Van Nuys, California | |
| InvivoCure -2 Alhambra, California | |
| Iwate Prefectural Central Hospital_Cardiology Morioka-shi, Iwate, | |
| JA Shizuoka Kohseiren Enshu Hospital_Internal Medicine Shizuoka, | |
| JPJ Research Northridge, California | |
| JSS Hospital, Mysore Mysuru, Karnataka | |
| Jacksonville Ctr for Clin Res Jacksonville, Florida | |
| Jantar Sp. z o.o. Ostrów Wielkopolski, | |
| Japanese Red Cross Wakayama Medical Center_Department of Cardiology Wakayama-shi, Wakayama, | |
| Javara Inc. / Privia Medical Group Gulf Coast PLLC Conroe, Texas | |
| Jawaharlal Nehru Medical College and Hospital Aligarh, Uttar Pradesh | |
| Jeroen Bosch Zkh 's-Hertogenbosch, | |
| Jersey City Medical Center Jersey City, New Jersey | |
| Jinan Central Hospital-Cardiovascular Jinan, Shandong | |
| Jmf Clínica Do Coração Ltda Aracaju, | |
| Joe C.Wen & Fam CTR for Adv Care Irvine, California | |
| John Muir Physicians Network Concord, California | |
| Jongaie Research Pretoria, Gauteng | |
| K&R Research Llc Marion, Ohio | |
| K2 Medical Research Maitland, Florida | |
| KARDIA - Dr. Hashemi Berlin, | |
| KG Hospital and PG Medical Institute & Research Centre Coimbatore, Tamil Nadu | |
| KLES Dr. Prabhakar Kore Hospital & Medical Research Centre Belagavi, Karnataka | |
| Kagawa Prefectural Central Hospital_Cardiovascular Medicine Takamatsu-shi, Kagawa, | |
| Kaiser Permanente Northern California San Francisco, California | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital_Dept of Internal medicine Kaohsiung City, | |
| Kardio Elbl s.r.o. Brno - Sever, | |
| Kardio Life - Tomasz Borkowski Włocławek, | |
| Kardiologicka ambulance Brno s.r.o. Brno, | |
| Kardiologie - Ústí nad Labem s.r.o. Ústí nad Labem, | |
| Kardiologie MUDr. Libor Nechvátal s.r.o. Brno, | |
| Kardiologie a Angiologie Praha s.r.o. Prague, | |
| Kardiologie im Spreebogen Berlin, | |
| Kardiologische Gemeinschaftspraxis Papenburg Papenburg, | |
| Kardiologische Praxis Ludwigshafen Ludwigshafen am Rhein, | |
| Kardiopraxis Schirmer Kaiserslautern, | |
| Karnataka Medical College and Research Institute Hubbali, Karnataka | |
| Kasugai Municipal Hospital_Cardiovascular Medicine Kasugai-shi, Aichi, | |
| Kath. Hospitalvereinigung Thüringen gGmbH - KKH St. Johann Nepomuk - Innere Med. II Erfurt, | |
| Kath. Klinikum Bochum gGmbH - St. Josef-Hospital Kardiologie Bochum, | |
| Kawartha Cardiology Clinical Trials Peterborough, Ontario | |
| Kayseri Şehir Hastanesi-Kardiyoloji Kayseri, | |
| Keimyung University Dongsan Hospital_Cardiology Daegu, | |
| King George's Medical University (KGMU) Lucknow, Uttar Pradesh | |
| King's College Hospital - Cardiology London, | |
| Klinika Dr. Pírka s.r.o. Mladá Boleslav, | |
| Kliniken Südostbayern AG - Klinikum Traunstein Traunstein, | |
| Kocaeli Üniversitesi Hastanesi- Kardiyoloji Kocaeli, | |
| Konstantopouleio G.H. of Athens, "Agia Olga" Athens, | |
| Korea University Anam Hospital_Cardiology Seoul, | |
| Korea University Guro Hospital_Cardiology Seoul, | |
| Krishna Vishwa Vidyapeeth Karad, Maharashtra | |
| Kütahya Şehir Hastanesi-Kardiyoloji Kütahya, | |
| LES HOPITAUX DE CHARTRES_HOPITAL LOUIS PASTEUR_Service de Cardiologie Le Coudray, | |
| Laurelton Heart Specialist PC Rosedale, New York | |
| Life Care Hospital and Research Centre Bangalore, Karnataka | |
| Life Clinical Research Ipswich, Queensland | |
| Lincoln County Hospital Lincoln, | |
| Lindner Center,Christ Hospital Cincinnati, Ohio | |
| Lisie Hospital Kochi, | |
| Lister Hospital Stevenage, | |
| Louis Stokes Clvlnd VA Med Ctr Cleveland, Ohio | |
| Lps Institute of Cardiology, Gsvm Medical College Kanpur, Uttar Pradesh | |
| Lyell McEwin Hospital - Clinical Trials Unit Elizabeth Vale, South Australia | |
| MBAL Trakia EOOD Stara Zagora, | |
| MC Diamedical - 2013 OOD, Dimitrovgrad Dimitrovgrad, | |
| MC Diamedical - 2013 OOD, Sofia Sofia, | |
| MC Hera EOOD - Sofia Sofia, | |
| MC Nevromedics EOOD, Cardiology Veliko Tarnovo, | |
| MEDICUS SERVICES s.r.o. Brandýs nad Labem, | |
| MHAT - City Clinic - Sveti Georgi EOOD Montana, | |
| MHAT - Dobrich AD, Cardiology Dobrich, | |
| MHAT - Ivan Skenderov EOOD Gotse Delchev, | |
| MHAT Heart and Brain EAD - Burgas, Cardiology Burgas, | |
| MHAT Heart and Brain EAD - Pleven, Cardiology Pleven, | |
| MHAT Sveta Sofia EOOD Sofia, | |
| MIT Medicina, Investigación y tratamiento Santa Rosa, La Pampa, | |
| MVZ CCB Frankfurt Und Main-Taunus GbR Frankfurt, | |
| MVZ im Altstadt-Carree Fulda GmbH - Zentrum für klinische Studien Fulda, | |
| Maasstad Ziekenhuis - Cardiologie Rotterdam, | |
| Main Heart Clinic Houston, Texas | |
| MaineHealth Cardiology - Biddeford Biddeford, Maine | |
| Malla Reddy Narayana Multispeciality Hospital Hyderabad, Telangana | |
| Marienhaus Klinikum Mainz GmbH - Innere Medizin I Mainz, | |
| Marmara Üniversitesi Pendik EAH- Kardiyoloji Istanbul, | |
| Marshfield Clinic Marshfield, Wisconsin | |
| Maxima MC Veldhoven - Cardiologie Veldhoven, | |
| Med Trust Research, Inc. Courtice, Ontario | |
| Med. Uni. of SC Ashley River T Charleston, South Carolina | |
| Medanta - The Medicity Multi-Speciality Hospital, Gurugram Gurgaon, Haryana | |
| Medical Care and Research S. A de C.V Mérida, Yucatán | |
| Medical Center Cardiohelp EOOD, Cardiology Consulting room Sofia, | |
| Medical Center Medconsult Pleven OOD Pleven, | |
| Medical Center Medica Plus Ltd. Veliko Tarnovo, | |
| Medical Center Nov Rehabilitatsionen center EOOD Stara Zagora, | |
| Medical center ISUL - Tsaritsa Yoanna EOOD Sofia, | |
| Medical center Kalimat EOOD Sofia, | |
| Medical center Medconsult Burgas OOD Burgas, | |
| Medical centre Zdrave 1 OOD Kozloduy, | |
| Meditrial Clinical Research Centre Pietermaritzburg, KwaZulu-Natal | |
| Medizentrum Essen-Borbeck Essen, | |
| Medizinisches Versorgungszentrum Am Bahnhof Spandau GbR Berlin, | |
| Medon Clinical Research Sp. z o.o. Warsaw, | |
| Medrasa Clinical Research Wylie, Texas | |
| Mehmet Akif Ersoy Göğüs Kalp ve Damar Cerrahisi EAH Istanbul, | |
| Mercy Gilbert Medical Center Gilbert, Arizona | |
| Mercy Medical Center, GI Research Baltimore, Maryland | |
| Mersin Üniversitesi Hastanesi- Kardiyoloji Mersin, | |
| Metabolica Sp. z o.o. Tarnów, | |
| Metropolitan General Hospital Healthcare Facilities Operation And Management Single Member S.A. - Cardiology Clinic Athens, | |
| Michal Tomaszewski Indywidualna Praktyka Lekarska Lublin, | |
| Midwest Cardiovascu Rsrch Foundation Davenport, Iowa | |
| Mission Cardiovascular Research Institute Fremont, California | |
| Mita Clinic of Internal Medicine and Cardiology_Cardiology Sapporo-shi, Hokkaido, | |
| Mobile Heart USA Health Cardiology Clinic Mobile, Alabama | |
| Mohak Bariatrics and Robotics Indore, Madhya Pradesh | |
| Monument Health Clinical Rsrch Rapid City, South Dakota | |
| Mount Sinai Hosp at NYC New York, New York | |
| Musgrove Park Hospital - Cardiology Taunton, | |
| NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine Bunkyo-ku, Tokyo, | |
| NSC Research, Inc Johns Creek, Georgia | |
| NYU Langone Med Assoc Chelsea New York, New York | |
| NYU Langone Orthopedic Center New York, New York | |
| NZOZ "Twoje Zdrowie EL" Sp. z o.o. Elblag, | |
| NZOZ SALUSMED Jan Zbigniew Peruga PPHU SALUS Lodz, | |
| Nagasaki Harbor Medical Center_Cardiovascular medicine Nagasaki, | |
| Nanjing Jiangning Hospital-Cardiovascular Nanjing, Jiangsu | |
| Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy Warsaw, | |
| National Center for Global Health and Medicine_Cardiology Shinjuku-ku, Tokyo, | |
| National Heart Institute Kuala Lumpur, | |
| National Heart Institute,India New Delhi, | |
| National Hospital Organization Chiba Medical Center_Cardiovascular Medicine Chiba-shi,Chiba, | |
| National Hospital Organization Kyoto Medical Center_Cardiology Kyoto-shi, Kyoto, | |
| National Hospital Organization Mito Medical Center_Cardiovascular medicine Ibaraki, | |
| Nature Coast Clinical Research Crystal River, Florida | |
| Nemocnice Jihlava, p.o. Jihlava, | |
| Niels-Stensen-Kliniken Marienhospital Osnabrück - Klinik für Innere Medizin, Kardiologie und Intensivmedizin Osnabrück, | |
| Nightingale Research Adelaide, | |
| Nightingale Research Victoria Frankston, Victoria | |
| Ninewells Hospital Dundee, | |
| Nkpsims & Rc , Lata Mangeshkar Hospital , Hingna Nagpur, Maharashtra | |
| Norfolk and Norwich University Hospital - Clinical Research Facility Norwich, Norfolk | |
| North Texas Research Associates McKinney, Texas | |
| North Tyneside General Hospital North Shields, | |
| North York Diagn & Cardiac Ctr North York, Ontario | |
| NorthBay Clinical Research Santa Rosa, California | |
| Northeast Georgia Medical Ctr Gainesville, Georgia | |
| Northwick Park Hospital - Cardiac Research Dept Harrow, | |
| Nova Scotia Health Halifax, Nova Scotia | |
| OCIPSMCC - Dr. Aleksandar Nosikov Sofia, | |
| Oaxaca Site Management Organization (OSMO) Oaxaca City, Oaxaca | |
| Ocala Cardiovascular Research Ocala, Florida | |
| Ordu Üniversitesi Eğitim ve Araştırma Hastanesi- Kardiyoloji Altınordu/Ordu, | |
| Oregon Health & Science University Portland, Oregon | |
| Ormond Beach Clinical Research Ormond Beach, Florida | |
| Osaka General Medical Center_Cardiology Osaka, | |
| Osaka Metropolitan University Hospital_Cardiovascular Medicine Osaka-Shi, Osaka, | |
| Osmania General Hospital Hyderabad, Telangana | |
| Ospedale Bellaria Carlo Alberto Pizzardi - UO Cardiologia e Unità coronarica Bologna, Emilia-Romagna | |
| Ospedale Ca' Foncello - U.O.C. Medicina Generale 1 Treviso, Veneto | |
| Ospedale Cremona - U.O. Cardiologia Cremona, Lombardy | |
| Ospedale Misericordia Grosseto - UOC Cardiologia Grosseto, Tuscany | |
| Ospedale S. Maria della Misericordia - Clinica Medica Udine Udine, Friuli Venezia Giulia | |
| Ospedale SS. Annunziata di Chieti - U.O. Clinica medica Medicina generale 1 Chieti, Abruzzo | |
| Ospedale San Raffaele S.r.l. - Unità Clinica Anestesia, Rianimazione e Terapia Intensiva Cardio-Toraco-Vascolare Milan, Lombardy | |
| Ospedale Santissima Annunziata - Dipartimento Cardio Toraco Vascolare Cosenza, Calabria | |
| Ospedale di Bentivoglio - UOC Cardiologia Bentivoglio, Emilia-Romagna | |
| Osrodek Badan Klinicznych LabMed Sp. z o.o. Szczecin, West Pomeranian Voivodeship | |
| Ota Memorial Hospital_Cardiology Ota-shi, Gunma, | |
| PHC Accelacare Statesville, North Carolina | |
| PUCCAMP - Hospital e Maternidade Celso Pierro Campinas, São Paulo | |
| Pacific Clinical Studies Los Alamitos, California | |
| Palm Research Center Inc-Vegas Las Vegas, Nevada | |
| Panamerican Clinical Research Mexico S. A de C.V Querétaro City, Querétaro | |
| Peachtree Cardiology Peachtree, Georgia | |
| Peak Clinical Trials Apex, North Carolina | |
| Penn Med. Lancaster Gen Hospital Lancaster, Pennsylvania | |
| Penn State Hlth Holy Spirit Med Ctr Camp Hill, Pennsylvania | |
| PharmaTex Research, LLC Amarillo, Texas | |
| Physicians East Endocrinology Greenville, North Carolina | |
| Piedmont Research Partners, LLC Fort Mill, South Carolina | |
| Pinderfields Hospital - Clinical Research & Innovation Wakefield, | |
| Pol. Uni. Campus Biomedico - UOC Cardiologia Rome, Lazio | |
| Policlinico San Donato di Milano S.p.A - UO Cardiologia Universitaria Perioperatoria e Riabilitativa San Donato Milanese, Lombardy | |
| Policum Berlin Studien GmbH - Friedenau Berlin, | |
| Pratia Czech, s.r.o Prague, | |
| Praxis Dr. med. Jens Taggeselle Markkleeberg, | |
| Praxis Joachim Heisters Kamp-Lintfort, | |
| Praxis für Innere Medizin, Kardiologie, Pneumologie - Köln Cologne, | |
| Princess of Wales Hospital Bridgend, | |
| Pro Familia Altera Sp. z o.o. Katowice, | |
| Proactive El Paso LLC El Paso, Texas | |
| Providence Health Partners Ctr Dayton, Ohio | |
| Prywatna Praktyka Lekarska Anna Chudoba Żyrardów, | |
| Pusan National University Yangsan Hospital_Cardiology Yangsan, Gyeongsangnam-do | |
| Raigmore Hospital Inverness, | |
| Rambam MC - Heart Failure Unit Haifa, | |
| Regionshospital Nordjylland, Hjørring - Afdelingen for hjerte- og hormonsygdomme Hjørring, | |
| Renal Disease Research Institute Dallas, Texas | |
| Research Integrity Global, LLC Owensboro, Kentucky | |
| Rhythm Heart Institute Vadodara, Gujarat | |
| Rigshospitalet - Kardiologisk Forskningsenhed København Ø, | |
| Robert-Bosch-Krankenhaus Stuttgart - Behandlungsexzellenz Bosch Health Campus Stuttgart, | |
| Rode Kruis Zkh Beverwijk - Cardiologie Beverwijk, | |
| Royal Cornwall Hospital (Treliske) Truro, Cornwall | |
| Royal Hobart Hospital - Cardiology Department Hobart, Tasmania | |
| Royal Victoria Infirmary Newcastle, England | |
| Ruppiner Kliniken - Universitätsklinikum Ruppin-Brandenburg Neuruppin, | |
| SAKAKIBARA HEART INSTITUTE_Cardiology Fuchu-shi,Tokyo, | |
| SEC Clinical Research Pensacola, Florida | |
| SHATC - Cardiolife OOD - Varna Varna, | |
| SIYODE S.A. de C.V. Unimeden Ciudad Madero, Tamaulipas | |
| SLK-Klinken Heilbronn - Klinikum am Plattenwald Bad Friedrichshall Bad Friedrichshall, | |
| SMC Heart Institute and IVF Research Centre Raipur, Chhattisgarh | |
| SPIMED, s.r.o. Česká Třebová, | |
| STAT Research Ohio Vandalia, Ohio | |
| Sakarya Eğitim ve Araştırma Hastanesi- Dahiliye Adapazarı/Sakarya, | |
| Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II Grodzisk Mazowiecki, | |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie Rzeszów, | |
| Samsun Şehir Hastanesi-Kardiyoloji Canik/Samsun, | |
| Samsung Medical Center_Cardiology Seoul, | |
| San Diego Veterans Affairs San Diego, California | |
| San Francisco V.A. Medical Center San Francisco, California | |
| Sana Kliniken Oberfranken Coburg GmbH - II. Med. Klinik, Kardiologie Coburg, | |
| Sanatorio Esperanza Esperanza, Santa Fe, | |
| Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Uttar Pradesh | |
| Sarawak General Hospital Kuching, Sarawak | |
| Schwarzwald-Baar Klinikum Villingen-Schwenningen GmbH Villingen-Schwenningen, | |
| Scientia Investigación Clínica S. C. Col. Zona Comercial Plaza Del Sol, Chihuahua | |
| Scripps Hospital Chula Vista, California | |
| Scripps Memorial Hospital La Jolla La Jolla, California | |
| Sekino Hospital_Internal Medicine Toshima-ku,Tokyo, | |
| Selma Medical Associates Winchester, Virginia | |
| Sengupta Hospital and Research Institute Nagpur, Maharashtra | |
| Sentara Health Research Center Norfolk, Virginia | |
| Seoul National University Bundang Hospital_Cardiology Seongnam-si, Gyeonggi-do | |
| Seoul National University Hospital_Cardiology Seoul, | |
| Serce Sp. z o.o. Leszno, Greater Poland Voivodeship | |
| Seth GS Medical College & KEM Hospital Mumbai, Maharashtra | |
| Severance Hospital, Yonsei University Health System_Cardiology Seoul, | |
| Shaanxi Provincial People's Hospital-Cardiology Xi'an, Shaanxi | |
| Shamir MC - Cardiology Department Beer Yaakov, | |
| Sherman Clinical Research Sherman, Texas | |
| Shinshu University Hospital__Department of Cardiology Matsumoto-shi, Nagano, | |
| Shri Mahant Indiresh Hospital Dehradun, | |
| Siping Central People's Hospital-Cardiology Siping, Jilin | |
| Sir Ganga Ram Hospital New Delhi, | |
| Sismanogleio General Hospital - Amalia Fleming Hospital, Cardiology Department Athens, | |
| Slaskie Centrum Chorob Serca w Zabrzu Zabrze, | |
| Soroka MC - Department of Cardiology Beersheba, | |
| South Texas Clinical Research Corpus Christi, Texas | |
| Southmead Hospital - Cardiology Research Bristol, | |
| Southwest Family Medicine_Dallas Dallas, Texas | |
| Spaarne Gasthuis Haarlem Haarlem, | |
| Specjalistyczny Szpital Im. E. Szczeklika W Tarnowie Tarnów, Lesser Poland Voivodeship | |
| Spedali Civili Brescia - U.O. Medicina Generale 2 Brescia, Lombardy | |
| Sri Ramachandra Medical Centre Chennai, Tamil Nadu | |
| St Bartholomew's Hospital London, | |
| St George's Hospital - Cardiology Tooting, London | |
| St Joseph's Hospital Foundation Tampa, Florida | |
| St Pauls Hospital Vancouver, British Columbia | |
| St. Antonius Zkh Nieuwegein - Cardiologie Nieuwegein, | |
| St. Boniface Hospital Winnipeg, Manitoba | |
| St. Joseph's Heath Centre Toronto, Ontario | |
| St. Joseph's Medical Center Stockton, California | |
| St. Luke's Idaho Cardiology Associates Meridian, Idaho | |
| St. Richard's Hospital_Cardiology Chichester, West Sussex | |
| Sun City Clinical Research Glendale, Arizona | |
| Suncoast Clinical Research, Inc. New Port Richey, Florida | |
| Sunderland Royal Hospital Sunderland, | |
| Svendborg Sygehus - Kardiologisk Svendborg, | |
| Swedish Medical Center_Seattle Seattle, Washington | |
| Sydney Cardiometabolic Centre Liverpool, New South Wales | |
| Sygehus Sønderjylland, Aabenraa - Afdeling for Hjertesygdomme Aabenraa, | |
| Synapta Clinical Research Durban, KwaZulu-Natal | |
| Synergy Biomed Research Institute East London, Eastern Cape | |
| Synvia Laboratorios E Toxicologia Ltda Campinas, São Paulo | |
| Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o. Krakow, | |
| TPMG Clinical Research Newport News, Virginia | |
| Taipei Mackay Memorial Hospital Taipei, | |
| Taipei Medical University Hospital Taipei, | |
| Tampa Cardiovascular Interventions and Research Tampa, Florida | |
| Texama Medical Center Denison, Texas | |
| Texas Health Heart and Vascular Specialists Dallas, Texas | |
| The Affiliated Hospital of Jining Medical University-Cardiology Jining, Shandong | |
| The Affiliated Hospital of Xuzhou Medical University-Cardiology Xuzhou, Jiangsu | |
| The Catholic University of Korea, Seoul ST. Mary's Hospital_Cardiology Seoul, | |
| The Catholic University of Korea. Uijeongbu St. Mary's Hospital_Cardiology Uijeongbu-si, Gyeonggi-do | |
| The First Affiliated Hospital of Harbin Medical University-Cardiovascular Harbin, Heilongjiang | |
| The First Affiliated Hospital of Jinan University-Cardiovascular Guangzhou, Guangdong | |
| The First Affiliated Hospital of Soochow University-Cardiology Suzhou, Jiangsu | |
| The First Hospital of Hebei Medical University-Cardiovascular Shijiazhuang, Hebei | |
| The First People's Hospital of Changzhou-Cardiology Changzhou, Jiangsu | |
| The GW Medical Faculty Associates Washington D.C., District of Columbia | |
| The Heart House Haddon Heights Haddon Heights, New Jersey | |
| The Jackson Clinic, PA Jackson, Tennessee | |
| The James Cook University Hospital - Cardiology Middlesbrough, | |
| The Medicity Super Speciality Hospital, Udham Singh Nagar, Uttarakhand | |
| The People's Hospital of Liaoning Province-Cardiology Shenyang, Liaoning | |
| The Prince Charles Hospital - Cardiology Clinical Research Centre Chermside, Queensland | |
| The Queen's Medical Center Honolulu, Hawaii | |
| The Research Group of Lexington LLC Lexington, Kentucky | |
| The Royal Oldham Hospital Oldham, | |
| The Third People's Hospital of Hubei Province (Qiaokou Campus)-Cardiology Wuhan, Wuhan | |
| The Valley Hospital Paramus Paramus, New Jersey | |
| Thomas Jefferson University Philadelphia, Pennsylvania | |
| Thoracic General Hospital Of Athens I Sotiria - Cardiology Department Athens, | |
| Tianjin People's Hospital-Cardiology Tianjin, Tianjin Municipality | |
| Tickerdoc Research (Pty) LTD Johannesburg, Gauteng | |
| Tiervlei Trial Centre Cape Town, Western Cape | |
| Tokyo-Eki Center-building Clinic_Internal Medicine Tokyo, | |
| Tomakomai City Hospital_Cardiology Tomakomai-Shi, Hokkaido, | |
| Torbay Hospital Torquay, | |
| Torre De Plaza Las Americas San Juan, | |
| Total Research Group LLC Miami, Florida | |
| Tread Research (Pty)Ltd Cape Town, Western Cape | |
| Trinity Health Michigan Heart Ypsilanti, Michigan | |
| Tsuchiura Kyodo General Hospital_Internal Medicine Ibaraki, | |
| Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o. Szczecin, | |
| U.G.H of Athens "Attikon" Chaidari, Athens, | |
| UCSD NAFLD Research Center La Jolla, California | |
| UMC Groningen - Cardiologie Groningen, | |
| UMC of Southern Nevada Las Vegas, Nevada | |
| UMHAT - Dr. Georgi Stranski EAD Pleven, | |
| UMHAT - EUROHOSPITAL PLOVDIV OOD, Department of Internal Diseases Plovdiv, | |
| UMHAT Aleksandrovska EAD, Clinic of Cardiology Sofia, | |
| UMHAT Sofiamed EAD Sofia, | |
| UMHAT Sveta Marina EAD, Second Clinic of Cardiology Varna, | |
| UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology Plovdiv, | |
| UMHATEM N.I. Pirogov EAD, Cardiology department Sofia, | |
| UTD SW Medical Center-Dallas Dallas, Texas | |
| Ulster Hospital Belfast, | |
| UniCardia & UniMedica & UniEstetica Krakow, | |
| Uniklinik Aachen - Med. Klinik I Aachen, | |
| Uniklinik Schleswig-Holstein - Med. Klinik III Kardiologie und Internist. Intensivmedizin Kiel, | |
| Uniklinik TU Dresden - Herzzentrum Dresden GmbH Dresden, | |
| UnityPoint Health-Diabetes Care Center Peoria, Illinois | |
| Univ Gen Hospital Larisa, Cardiology Medicine Clinic Larissa/Thessaly, | |
| Univ of Alabama Birmingham Birmingham, Alabama | |
| Univ of Colorado at Denver Aurora, Colorado | |
| Univ of Mississippi Med Center Jackson, Mississippi | |
| Univer Of Illinois at Chicago Chicago, Illinois | |
| Universidade Municipal de São Caetano do Sul (USCS) São Caetano Do Sul / SP, São Paulo | |
| Universitatsklinikum Würzburg - Zentrum für Herzinsuffizienz Würzburg, | |
| University Hospital Torino, | |
| University Hospital Coventry - Cardiology Research PRI Suite Coventry, | |
| University Hospital Monklands - Cardiology Research Airdrie, Lanarkshire | |
| University Malaya Medical Centre Lembah Pantai, | |
| University Technology MARA (UiTM) - Sg Buloh Sungai Buloh, Selangor | |
| University of Calgary Calgary, Alberta | |
| University of Iowa Iowa City, Iowa | |
| University of Michigan Ann Arbor, Michigan | |
| University of Rochester Rochester, New York | |
| University of Virginia Hospital Charlottesville, Virginia | |
| Universitätsklinikum Frankfurt aM - Kardiologie Frankfurt am Main, | |
| Universitätsklinikum Freiburg - Medical Center Freiburg im Breisgau, | |
| Universitätsklinikum Münster - Klinik für Kardiologie I Münster, | |
| Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi Lodz, Łódź Voivodeship | |
| Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu Wroclaw, | |
| Uniwersytecki Szpital Kliniczny nr 4 w Lublinie Lublin, | |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Bialystok, | |
| Uniwersyteckie Centrum Medycyny Morskiej i Tropikalnej Gdynia, | |
| UofL Health Care Outpatient Louisville, Kentucky | |
| Uwajima City Hospital_Cardiology Uwajima-shi, Ehime | |
| VA Eastern Colorado Health Care System Aurora, Colorado | |
| VAGrtrLosAngelesHlthcareSystem Los Angeles, California | |
| VMMC & Safdarjung Hospital New Dehli, New Delhi | |
| Valiance Clinical Research Huntington Park, California | |
| Valiance Clinical Research Huntington Park, California | |
| Valley Clinical Trials Northridge, California | |
| Valley Clinical Trials Northridge, California | |
| Van Weel-Bethesda Zkh - Cardiologie Dirksland, | |
| Velocity Clinical Research Lincoln Lincoln, Nebraska | |
| Velocity Nova Sp. z o.o. Zamość, | |
| Velocity Nova Sp. z o.o. Zamość, | |
| Viborg Sygehus Viborg, | |
| Victoria Hospital London, Ontario | |
| Victorium Clinical Research Houston, Texas | |
| VieCuri - Cardiologie Venlo, | |
| Vijan Hospital & Research Centre Nashik, Maharashtra | |
| Virginia Commonwealth University Richmond, Virginia | |
| WMF's Villoo Poonawalla Memorial Hospital Pune, | |
| WVU Medicine Morgantown, West Virginia | |
| WakeMed_Cardiology Raleigh, North Carolina | |
| Washington University St Louis, Missouri | |
| West Houston Area Clinical Trial Consultants Wichita, Kansas | |
| West Middlesex University Hospital Isleworth, Middlesex | |
| Westchester Medical Center Valhalla, New York | |
| Westside Medical Associates Los Angeles Beverly Hills, California | |
| Winchester Dist Memorial Hosp Winchester, Ontario | |
| Wits Bara Clinical Trial Site Johannesburg, Gauteng | |
| Wits Clinical Research Johannesburg, Gauteng | |
| Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu Przemyśl, | |
| Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika Lodz, | |
| Women's College Hospital Toronto, Ontario | |
| Wonju Severance Christian Hospital_Cardiology Wŏnju, Gangwon-do | |
| Worcestershire Royal Hospital_Cardiology Worcester, | |
| Yamanashi Prefectural Central Hospital_Cardiology Kofu-shi, Yamanashi, | |
| Yokohama City University Hospital_Cardiovascular Medicine Yokohama-shi，Kanagawa, | |
| Yokohama City University Medical Center_Cardiovascular Center Kanagawa, | |
| Zentrum für klinische Studien Südbrandenburg GmbH Elsterwerda, | |
| Zhongshan Hospital, Fudan University-Cardiology Shanghai, Shanghai Municipality | |
| Ziv MC - Cardiology Department Safed, | |
| Zuyderland ziekenhuis - Cardiologie Heerlen, | |
| cardiologicum Hamburg - Studienzentrum Hamburg, | |
| Çanakkale Onsekiz Mart Üniversitesi Sağlık Araştırma ve Uygulama Hastanesi- Kardiyoloji Çanakkale/Türkiye, | |
| İnönü Üniversitesi Turgut Özal Tıp Merkezi - Kardiyoloji Malatya, | |
| İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü Istanbul, | |
| İzmir Atatürk Eğitim Ve Araştırma Hastanesi- Kardiyoloji Izmir, | |
| İzmir Şehir Hastanesi- Kardiyoloji Bayraklı/İzmir, |
Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials
Jonathan Soslow, MD, MSCI - DMDMachineLearning@vumc.org
NCT07674758
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Inclusion Criteria:
* Clinical phenotype of Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or muscular dystrophy carrier (MDC) confirmed with muscle biopsy or genotype
Exclusion Criteria:
* Additional genetic or congenital abnormality that may affect cardiovascular function or progression
* Current investigational therapy that may affect cardiovascular function (would preclude ongoing data collection but prior data would still be used) Duchenne Muscular Dystrophy (DMD), Cardiomyopathy, Becker Muscular Dystrophy, Carrier of Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy, cardiomyopathy, machine learning, cardiac MRI, Biomarker, Outcome measures
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Study Locations
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| Location | Contacts |
|---|---|
| Children's Hospital of Richmond at VCU Richmond, Virginia | Study Coordinator - (DMDmachinelearning@vumc.org) |
| Children's National Washington D.C., District of Columbia | Study Coordinator - (DMDmachinelearning@vumc.org) |
| Duke Children's Hospital Durham, North Carolina | Study Coordinator - (DMDmachinelearning@vumc.org) |
| Lurie Children's Chicago, Illinois | |
| Nationwide Children's Columbus, Ohio | Study Coordinator - (DMDmachinglearning@vumc.org) |
| Riley Children's Hospital Indianapolis, Indiana | Study Coordinator - (DMDMachineLearning@vumc.org) |
| Seattle Children's Seattle, Washington | Study Coordinator - (DMDmachinelearning@vumc.org) |
| UC Davis Sacramento, California | Study Coordinator - (DMDmachinelearning@vumc.org) |
| Vanderbilt University Medical Center Nashville, Tennessee | Study Coordinator - (DMDMachineLearning@vumc.org) |
Endocardial Mapping With the CoreMap EP Mapping System (INvENI)
Jim Foster, SysEng - jfoster@coremapmedical.com
NCT06529978
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Inclusion Criteria:
• Subject has persistent or long-standing persistent AF, at the discretion of the investigator (Phase 1 \& 2)
• Subject has PerAF with no history of prior AF ablation therapy (Phase 3)
• Subject is 18 to 80 years of age
• Subject has presence of AF-related symptoms and is scheduled for clinically indicated standard of care AF ablation to manage PerAF (Phase 2 or 3) or long-standing PerAF (Phase 2)
• Subject is able to provide written informed consent
• Subject is able and willing to complete all study procedures
Exclusion Criteria:
• Any of the following within three months of enrollment:
• Myocardial infarction (MI)
• Any surgical or percutaneous cardiac procedure including coronary intervention and cardiac ablation
• Confirmed thrombus on imaging
• Any of the following within six months of enrollment:
• Cardiac surgery including coronary artery bypass grafting, ventriculotomy, atriotomy
• Thromboembolic event (stroke)
• Any of the following cardiac conditions:
• New York Heart Association (NYHA) IV
• Left ventricular ejection fraction (LVEF) \< 30%
• Left atrial diameter \>55mm (anterioposterior) (Phase 3)
• Carotid stenting or endarterectomy
• Atrial or ventricular septal closure or left atrial appendage closure
• Implanted permanent pacemaker, biventricular pacemaker, or any type of implantable cardiac defibrillator; loop recorders are permitted.
• Presence of intramural thrombus, tumor (including atrial myxoma), or other abnormality that precludes vascular access, catheter introduction, or manipulation
• Unstable angina
• Prior mitral or tricuspid valve surgery, repair, prosthetic or mechanical valve
• Moderate to severe mitral valve stenosis or other severe valvular disease
• Any blood clotting or bleeding abnormalities
• Contraindication to systemic anticoagulation
• AF secondary to electrolyte imbalance, acute alcohol intoxication, or reversible or non-cardiac cause
• Body mass index (BMI) \> 40 kg/m2
• Severe pulmonary disease, pulmonary hypertension, or any chronic respiratory condition
• Renal failure requiring dialysis or transplant
• Acute illness, active systemic infection, or sepsis
• Active drug or alcohol dependency
• Hypertrophic cardiomyopathy or cardiac amyloidosis
• Cor pulmonale
• Any contra-indication that may extend procedure time, at the discretion of the operator
• Any woman known to be pregnant or breastfeeding, or any woman of childbearing potential who is not on a reliable form of birth regulation method or abstinence
• Subject considered part of vulnerable population
• Life expectancy less than one year
• Employee of the study site or Sponsor
• Subjects who are currently enrolled in another study that would directly interfere with this study
DEVICE: CoreMap EP Mapping System Mapping, DEVICE: CoreMap EP Mapping System Map-Guided Ablation
Persistent Atrial Fibrillation
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Show 4 locations
Study Locations
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| Location | Contacts |
|---|---|
| NCH Downtown Baker Hospital Naples, Florida | |
| Na Homolce Hospital Praha Klanovice, | |
| University of Vermont Medical Center Burlington, Vermont | |
| Virginia Commonwealth University (VCU) Richmond, Virginia |