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123 Study Matches
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
BioNTech clinical trials patient information - patients@biontech.de
NCT06712316
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Key
Inclusion Criteria:
* Have systemic treatment naive, histologically or cytologically confirmed diagnosis of Stage IIIB or IIIC (who are not amenable to curative surgery or radiotherapy) or Stage IV NSCLC per the Union Internationale contre le Cancer/American Joint Committee on Cancer staging system, 9th edition.
* Have at least one measurable lesion as the targeted lesion based on RECIST v1.1. Lesions treated after prior local treatment (radiotherapy, ablation, interventional procedures, etc.) are generally not considered as target lesions. If the lesion with prior local treatment is the only targeted lesion, evidence-based radiology must be provided to demonstrate disease progression (the single bone metastasis or the single central nervous system metastasis should not be considered as a measurable lesion).
* Eastern Cooperative Oncology Group Performance Status of 0 or 1.
* Adequate organ function.
Key Exclusion Criteria:
* Have histologically or cytologically confirmed NSCLC with small-cell lung cancer histologic or neuroendocrine component.
* Have received any of the following therapies or drugs within the noted time intervals prior to study treatment:
* Previous chemotherapy (platinum-based) or PD(L)-1 for treating NSCLC in either neo-adjuvant/adjuvant or locally advanced/metastatic setting.
* Participants who received prior treatment with anti-VEGF monoclonal antibody, or PD(L)-1/VEGF bispecific antibody
* Have received systemic corticosteroids (at a dosage greater than 10 mg/day of prednisone or an equivalent dose of other corticosteroids) within 7 days prior to the initiation of study treatment. Note: local, intranasal, intraocular, intra-articular or inhaled corticosteroids, short-term use (\<=7 days) of corticosteroids for prophylaxis (e.g., prevention of contrast agent allergy) or treatment of non-autoimmune conditions (e.g., delayed hypersensitivity reactions caused by exposure to allergens) are allowed.
* Have uncontrolled hypertension or poorly controlled diabetic conditions prior to study treatment.
* Have a serious or non-healing wound, or (incompletely healed) bone fracture. This includes history (within 6 months prior to study entry) or risk of abdominal fistula, tracheoesophageal fistula, gastrointestinal perforation, or intra-abdominal abscess or esophageal and gastric varices. In addition, the participant must have undergone correction (or spontaneous healing) of the perforation/fistula and/or the underlying process causing fistula/perforation.
* Participants with significant risk of hemorrhage (per investigator clinical judgment).
* Have superior vena cava syndrome or symptoms of spinal cord compression.
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply. DRUG: Pumitamig, DRUG: Pembrolizumab, DRUG: Carboplatin, DRUG: Pemetrexed, DRUG: Paclitaxel
Non-small Cell Lung Cancer
First-line treatment, Combination with chemotherapy, Combination with other investigational agents, Bispecific antibody, Programmed death-ligand 1 (PD-L1), Vascular endothelial growth factor (VEGF) A, Immunotherapy, Programmed Death-1 monoclonal antibodies
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Show 206 locations
Study Locations
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| Location | Contacts |
|---|---|
| Acibadem Adana Hospital Seyhan, Adana | |
| Adana City Training and Research Hospital Adana, | |
| Affiliated Hospital of Hebei University Baoding, | |
| Ageo Central General Hospital Ageo, | |
| Ajou University Hospital Suwon, Kyǒnggi-do | |
| Akdeniz University Hospital Antalya, | |
| Alaska Oncology and Hematology, Llc Anchorage, Alaska | |
| Ankara Bilkent City Hospital Ankara, | |
| Asan Medical Center (AMC) Seoul, | |
| Asklepios Fachkliniken Muenchen Gauting Gauting, | |
| Astera Cancer Care East Brunswick, New Jersey | |
| Azienda Ospedaliera San Giuseppe Moscati Avellino, | |
| Azienda Ospedaliero Universitaria Di Bologna Policlinico S. Orsola Malpighi Bologna, | |
| Azienda Socio Sanitaria Territoriale di Cremona (ASST Cremona) Cremona, | |
| Baptist Cancer Center Memphis, Tennessee | |
| Baptist Health Hardin Elizabethtown, Kentucky | |
| Baskent Universitesi Tip Fakultesi Adana Hastanesi Adana, | |
| Beatson West of Scotland Cancer Centre - Greater Glasgow Health Board Glasgow, | |
| Beijing Friendship Hospital, Capital Medical University Beijing, | |
| Bezmialem Foundation University Medical Faculty Istanbul, | |
| CHU Caen Normandie Caen, | |
| CHU HELORA, Hopital de Mons - Site Kennedy Mons, | |
| CHU de Rennes, Hopital de Pontchaillou Rennes, | |
| Cairns Hospital Cairns, | |
| Cancer And Haematology Centre-The Churchill Hospital-Oxford University Hospitals Oxford, | |
| Cancer Care Wollongong Pty Limited Wollongong, | |
| Cancer Hospital of Shantou University Medical College Shantou, | |
| Cancer Research SA (CRSA) Adelaide, | |
| Cardiomed Cluj-Napoca, | |
| Casa Di Cura Polispecialistica Dott Pederzoli Peschiera del Garda, | |
| Central West Cancer Care Centre Orange, | |
| Centre Francois Baclesse Caen, | |
| Centre Hospitalier Intercommunal Toulon La Seyne Sur Mer (C.H.I.T.S) - Hospital Font-Pre Toulon, | |
| Centre Hospitalier Intercommunal de Creteil (CHIC) - Centre de ressources et de competences pour la mucoviscidose (C.R.C.M.) Créteil, | |
| Centre Hospitalier Universitaire d'Angers (CHU Angers) Angers, | |
| Centro di Riferimento Oncologico Aviano, | |
| Centrul de Oncologie Sf. Nectarie S.R.L (Sf Nectarie Oncology Center) Craiova, | |
| Chiangrai Prachanukroh Hospital Chiang Rai, | |
| Chongqing University Three Gorges Hospital Wanzhou, | |
| Chulalongkorn University Bangkok, | |
| Chungbuk National University Hospital Cheongju-si, Chungcheongbuk-do [Chungbuk] | |
| Chungnam National University Hospital (CNUH) Daejeon, | |
| Clatterbridge Cancer Centre Metropolitan Borough of Wirral, | |
| Clermont Oncology Center Clermont, Florida | |
| Cleveland Clinic Cleveland, Ohio | |
| Cleveland Clinic - Hillcrest Hospital Mayfield Heights, Ohio | |
| Cleveland Clinic Florida - Martin North Hospital Stuart, Florida | |
| Cleveland Clinic Weston Hospital Weston, Florida | |
| Clinica MD Anderson International Madrid, | |
| Coltea Clinical Hospital Bucharest, | |
| Complejo Hospitalario Universitario Insular Materno Infantil Las Palmas de Gran Canaria, | |
| Consorcio Hospitalario Provincial de Castellon Castellon, | |
| Dicle University Faculty of Medicine Hospital Diyarbakır, | |
| Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital Ankara, | |
| Dubbo Hospital Dubbo, | |
| Evangelische Lungenklinik Berlin Berlin, | |
| Faculty of Medicine Vajira Hospital, Navamindradhiraj University Bangkok, | |
| Fletcher Hospital, Inc. dba AdventHealth Hendersonville Hendersonville, North Carolina | |
| Flinders Medical Centre Bedford PK, South Australia | |
| Fondazione Ospedale Isola Tiberina - Gemelli Isola Rome, | |
| Fondazione Policlinico Universitario Campus Bio-Medico Roma, | |
| Frederick Health Hospital- James M Stockman Cancer Institute Frederick, Maryland | |
| Fundacion Instituto Valenciano de Oncologia Valencia, | |
| Gabrail Cancer Center Research Canton, Ohio | |
| Gachon University Gil Medical Center Namdong-gu, Incheon-gwangyeoksi [incheon] | |
| Gazi University Faculty of Medicine Yenimahalle, | |
| Gaziantep Sanko University Medical Faculty Gaziantep, | |
| Goztepe Prof. Dr. Suleyman Yalcin City Hospital Kadıköy, | |
| Gulhane Training and Research Hospital Ankara, | |
| Gyeongsang National University Hospital (GNUH) Jinju, | |
| H. Lee Moffit Cancer center and research institute Tampa, Florida | |
| HRH Princess MahaChakri Sirindhorn Medical Center - Srinakharinwirot University Nakhon Nayok, | |
| Hacettepe University Medicine Faculty Ankara, | |
| Helios Klinikum Wuppertal-Universitaet Witten-Herdecke Wuppertal, | |
| Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics Iowa City, Iowa | |
| Hospital General Universitario Gregorio Maranon (HGUGM) Madrid, | |
| Hospital General Universitario de Valencia Valencia, | |
| Hospital Universitari de Lleida Arnau de Villanova Lleida, | |
| Hospital Universitario De Leon León, | |
| Hospital Universitario Fundacion Jimenez Diaz Madrid, | |
| Hospital Universitario Miguel Servet de Zaragoza Zaragoza, | |
| Hospital Universitario Nuestra Señora de Valme Seville, | |
| Hospital Universitario Puerta de Hierro de Majadahonda Majadahonda, | |
| Hospital Universitario Vall d'Hebron Barcelona, | |
| Hospital Universitario Virgen del Rocio Seville, | |
| Hospital Universitario de Badajoz Badajoz, | |
| Hospital Universitario de Canarias San Cristóbal de La Laguna, Santa Cruz De Tenerife | |
| Hospital Álvaro Cunqueiro Vigo, | |
| Hull University Teaching Hospitals NHS Trust Cottingham, | |
| ICON Cancer Care - Townsville Townsville, | |
| IRCCS Istituto Romagnolo per lo studio dei Tumori Dino Amadori (IRST) Meldola, | |
| Icon Cancer Centre Kurralta Park Kurralta Park, | |
| Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest Bordeaux, | |
| Institut Catala d'Oncologia Badalona, Hospital Germans Trias I Pujol Badalona, | |
| Institut Curie - Centre de Recherche Paris, | |
| Institut Gustave Roussy-Gustave Roussy Cancer Center -Ditep Villejuif, | |
| Institut Paoli-Calmettes Marseille, | |
| Institut de Cancerologie de l'Ouest (ICO)- CRLCC Rene Gauducheau Saint-Herblain, | |
| Instytut MSF Sp. z o.o. Lodz, | |
| Integris Cancer Institute of Oklahoma Oklahoma City, Oklahoma | |
| Istinye University Bahcesehir Liv Hospital Istanbul, | |
| Istituti di Ricovero e Cura A Carattere Scientifico (IRCCS) - Istituti Fisioterapici Ospitalieri (IFO) - Istituto Nazionale Tumori Regina Elena (IRE) Roma, | |
| Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele (HSR) (Istituto Scientifico Universitario San Raffaele) Milan, | |
| Iwate Medical University Hospital Morioka, | |
| Jiangsu Peoples Hospital Nanjing, | |
| Jilin Cancer Hospital Changchun, | |
| John Muir Clinical Research Center Concord, California | |
| Karadeniz Technical University Faculty of Medicine Ortahisar, | |
| Kettering Medical Center Kettering, Ohio | |
| Klinikum Chemnitz gGmbH Chemnitz, | |
| Klinikum Esslingen GmbH Esslingen am Neckar, | |
| Koc Universitesi Hastanesi (Koc University Hospital) Zeytinburnu, | |
| Kocaeli Universitesi Tip Fakultesi Kocaeli, | |
| Korea University Guro Hospital Seoul, Seoul-teukbyeolsi [Seoul] | |
| Lampang Cancer Hospital Lampang, | |
| Liv Hospital Ankara Ankara, | |
| Lungenfachklinik Immenhausen - Pneumologische Lehrklinik der Universitaet Goettingen Immenhausen, | |
| MVZ for oncology and hematology Rhein-Kreis Neuss GmbH Neuss, | |
| Mary Lanning Healthcare (MLH) - Morrison Cancer Center (MCC) Hastings, Nebraska | |
| Matsusaka Municipal Hospital Matsusaka, | |
| Medical Park Florya Hospital Küçükçekmece, | |
| Medical Park Seyhan Hospital Seyhan, | |
| Medical Point Izmir Hospital Izmir, | |
| Memorial Ankara Hospital Ankara, | |
| Mersin City Training and Research Hospital Toroslar, | |
| Millennium Research and Clinical Development, LLC Houston, Texas | |
| Monash University - Monash Health -Monash Medical Centre Melbourne, | |
| Municipal Hospital Ploiesti Ploieşti, | |
| NHO Kinki Chuo Chest Medical Center Sakai, | |
| NZOZ Medpolonia Sp. Z o.o. Poznan, | |
| Nagoya University Hospital Nagoya, Aichi-ken | |
| National Cancer Center Goyang-si, Kyǒnggi-do | |
| National Hospital Organization Himeji Medical Center Himeji, Hyōgo | |
| National Hospital Organization Iwakuni Clinical Center Iwakuni, | |
| National Hospital Organization Nagoya Medical Center Nagoya, Aichi-ken | |
| National Hospital Organization Shikoku Cancer Center Matsuyama, Ehime | |
| National Hospital Organization Tokyo Medical Center Meguro City, | |
| New Cross Hospital Wolverhampton, | |
| Niigata Cancer Center Hospital Niigata, Niigata | |
| Norfolk and Norwich University Hospital - Norfolk and Norwich University Hospitals NHS Foundation Trust Norwich, | |
| Northern Jiangsu Peoples Hospital (NJPH) Yangzhou, | |
| Onco Clinic Consult SA Craiova, | |
| Oncomed Timișoara, | |
| Ondokuz Mayis University Health Practice and Research Hospital Samsun, | |
| Onkologische Tagesklinik Remscheid Remscheid, | |
| Osaka Prefectural Hospital Organization Osaka International Cancer Institute Osaka, | |
| Ospedale San Luca Lucca, | |
| Ovidius Clinical Hospital Ovidiu, | |
| Peninsula & South Eastern Haematology and Oncology Group Frankston, | |
| Peter MacCallum Cancer Centre Melbourne, Victoria | |
| Physicians Clinic of Iowa Cedar Rapids, Iowa | |
| Praxiskooperation Bonn-Euskirchen-Rheinbach-Wesseling Wesseling, | |
| Radiotherapy Center Cluj Cluj-Napoca, | |
| Rajavithi Hospital Ratchathewi, | |
| Royal Adelaide Hospital Adelaide, | |
| Royal Marsden Hospital (RMH) - Royal Marsden NHS Foundation Trust Chelsea, | |
| Royal Marsden Hospital (Sutton) - Royal Marsden NHS Foundation Trust London, | |
| Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust Preston, | |
| Royal Sussex County Hospital - University Hospitals Sussex NHS Foundation Trust Brighton, | |
| S.C. Medisprof S.R.L, Oncologie medicala Cluj-Napoca, | |
| SC Gral Medical SRL Bucharest, | |
| SRH Wald-Kliniken Gera GmbH Gera, | |
| SSM Health Cancer Care - St. Clare Fenton, Missouri | |
| Sakarya University - Faculty of Medicine Sakarya, | |
| Samsung Medical Center Seoul, | |
| Sendai Kousei Hospital Miyagi, Sendai, | |
| Severance Hospital, Yonsei University Health System Seoul, | |
| Shandong University - Jinan Central Hospital Jinan, | |
| Shanghai Chest Hospital Shanghai, | |
| Shizuoka Cancer Center Nakatogari, Shizuoka | |
| Southampton General Hospital Southampton, | |
| Summit Medical Group PA Florham Park, New Jersey | |
| Suny-Stony Brook University Cancer Center Stony Brook, New York | |
| Taizhou Hospital of Zhejiang Province Linhai, | |
| The Catholic University of Korea, St. Vincent's Hospital Suwon, | |
| The Christ Hospital Cancer Center Cincinnati, Ohio | |
| The Christie NHS Foundation Trust Manchester, | |
| The Cleveland Clinic Cancer Center at Fairview Hospital, Moll Pavilion Cleveland, Ohio | |
| The First Affiliated Hospital of Soochow University Suzhou, Jiangsu | |
| The Valley Hospital - Valley Health System - The Robert and Audrey Luckow Pavilion Paramus, New Jersey | |
| Thoraxklinik-Heidelberg gGmbH Heidelberg, | |
| Tokyo Metropolitan Komagome Hospital Bunkyō City, | |
| UOC Oncoematologia AOU Luigi Vanvitelli Naples, | |
| Uniklinik RWTH Aachen Medizinische Klinik IV Aachen, | |
| Universita di Siena -Azienda Ospedaliera Universitaria Senese-Policlincio Santa Maria Alle Scotte Siena, | |
| Universitair Ziekenhuis Leuven Leuven, | |
| Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur) Valencia, | |
| University College Hospital London, | |
| University Medical Center of Johannes Gutenberg-University Mainz Mainz, | |
| University Of California - San Diego Moores Cancer Center La Jolla, California | |
| University of Cincinnati Medical Center Cincinnati, Ohio | |
| University of Tennessee Medical Center Knoxville, Tennessee | |
| Universitätsklinikum Erlangen Erlangen, | |
| Uniwersyteckie Centrum Kliniczne (UCK) - Klinika Onkologii i Radioterapii Gdansk, | |
| VCU Massey Cancer Center Richmond, Virginia | |
| VITAZ Sint-Niklaas, | |
| Velindre NHS Trust, Velindre Cancer Centre Cardiff, | |
| Virginia Cancer Specialists Fairfax, Virginia | |
| Wakayama Medical University Hospital Wakayama, | |
| Western Health Sunshine Hospital St Albans, | |
| White Plains Hospital White Plains, New York | |
| Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu Przemyśl, | |
| Yeditepe University Kosuyolu Hospital Istanbul, | |
| Yunnan Provincial Cancer Hospital Kunming, | |
| Zhejiang Medical University, Zhejiang Cancer Hospital Hangzhou, | |
| Zhongnan Hospital of Wuhan University Wuhan, |
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com - Clinical.Trials@bms.com
NCT07100080
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Inclusion Criteria:
* Non-squamous NSCLC, not amenable to treatment in curative intent.
* Documented evidence of EGFR mutation (exon 19 deletion, L858R mutation).
* Progressive disease on a 3rd-generation (such as osimertinib, furmonertinib, lazertinib,...) EGFR-TKI-based mono- or combination therapy regimen as the most recent line of therapy in an adjuvant, locally advanced, or metastatic treatment setting.
* Eligible to receive a platinum-based doublet chemotherapy regimen (either cisplatin or carboplatin in combination with pemetrexed).
Exclusion criteria:
* Inadequate organ function and/or bone marrow reserve.
* Leptomeningeal metastases or spinal cord compression.
* Poorly controlled systemic medical conditions.
* Other protocol-defined inclusion/exclusion criteria apply. DRUG: Iza-bren, DRUG: Carboplatin, DRUG: Cisplatin, DRUG: Pemetrexed
Non-small Cell Lung Cancer
Epidermal Growth Factor Receptor, Tyrosine Kinase Inhibitors, Osimertinib, Standard of Care, Lung Neoplasms, Antineoplastic Agents, Izalontamab brengitecan, Iza-bren, BL-B01D1, Carboplatin, Cisplatin, Pemetrexed
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Show 186 locations
Study Locations
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| Location | Contacts |
|---|---|
| Cantonal Hospital St.Gallen Sankt Gallen, Canton of St. Gallen | |
| Dana-Farber Cancer Institute Boston, Massachusetts | |
| E-DA Hospital Kaohsiung City, | |
| Fujian Cancer Hospital Fuzhou, | |
| Hospital of the University of Pennsylvania Philadelphia, Pennsylvania | |
| Jiangmen Center Hospital Jiangmen, Guangdong | |
| John B Amos Cancer Center Columbus, Georgia | |
| Kantonsspital Baden Baden, | |
| Local Institution - 0004 ABB, Buenos Aires F.D. | |
| Local Institution - 0005 Santiago, Santiago Metropolitan | |
| Local Institution - 0006 Santiago, Santiago Metropolitan | |
| Local Institution - 0007 Santiago, Santiago Metropolitan | |
| Local Institution - 0008 Ciudad Autónoma de Buenos Aires, Buenos Aires | |
| Local Institution - 0010 Lille, Hauts-de-France | |
| Local Institution - 0011 Paris, | |
| Local Institution - 0012 Marseille, | |
| Local Institution - 0014 Strasbourg, Alsace | |
| Local Institution - 0015 Paris, | |
| Local Institution - 0017 Toulouse, Haute-Garonne | |
| Local Institution - 0018 La Tronche, Isère | |
| Local Institution - 0019 Villejuif, Val-de-Marne | |
| Local Institution - 0022 Yvoir, Namur | |
| Local Institution - 0023 Ghent, Oost-Vlaanderen | |
| Local Institution - 0024 Sint-Niklaas, Oost-Vlaanderen | |
| Local Institution - 0025 Houston, Texas | |
| Local Institution - 0028 Ravenna, Emilia-Romagna | |
| Local Institution - 0029 Parma, | |
| Local Institution - 0031 Orbassano, Piedmont | |
| Local Institution - 0032 Milan, | |
| Local Institution - 0034 Naples, | |
| Local Institution - 0036 Aviano, Friuli Venezia Giulia | |
| Local Institution - 0042 Seoul, Seoul-teukbyeolsi [Seoul] | |
| Local Institution - 0043 Goyang-si, Kyǒnggi-do | |
| Local Institution - 0044 Seongnam, Kyǒnggi-do | |
| Local Institution - 0045 Seoul, Seoul-teukbyeolsi [Seoul] | |
| Local Institution - 0046 Suwon, Kyǒnggi-do | |
| Local Institution - 0054 Athens, Attikí | |
| Local Institution - 0056 Thessaloniki, Kentrikí Makedonía | |
| Local Institution - 0060 Chaïdári, Attikí | |
| Local Institution - 0061 London, Kensington and Chelsea | |
| Local Institution - 0062 Thessaloniki, Thessaloníki | |
| Local Institution - 0069 Bengaluru, Karnataka | |
| Local Institution - 0070 New Delhi, National Capital Territory of Delhi | |
| Local Institution - 0071 Mumbai, Maharashtra | |
| Local Institution - 0072 Gurugram, Haryana | |
| Local Institution - 0073 Ahmedabad, Gujarat | |
| Local Institution - 0077 Mumbai, Maharashtra | |
| Local Institution - 0078 Howrah, West Bengal | |
| Local Institution - 0083 Ahmedabad, Gujarat | |
| Local Institution - 0085 Gainesville, Florida | |
| Local Institution - 0088 Pittsburgh, Pennsylvania | |
| Local Institution - 0089 Cheongju-si, Chungcheongbuk-do [Chungbuk] | |
| Local Institution - 0092 Seoul, Seoul-teukbyeolsi [Seoul] | |
| Local Institution - 0094 Córdoba, Córdoba Province | |
| Local Institution - 0095 Seoul, Seoul-teukbyeolsi [Seoul] | |
| Local Institution - 0097 Nagpur, Maharashtra | |
| Local Institution - 0103 Drammen, Buskerud | |
| Local Institution - 0105 Oslo, | |
| Local Institution - 0106 Bergen, Hordaland | |
| Local Institution - 0110 Glasgow, Glasgow City | |
| Local Institution - 0115 Bucharest, | |
| Local Institution - 0119 Iași, | |
| Local Institution - 0120 Bucharest, Bucharest | |
| Local Institution - 0123 Bucharest, Bucharest | |
| Local Institution - 0124 Iași, | |
| Local Institution - 0130 Craiova, Dolj | |
| Local Institution - 0132 Florești, Cluj | |
| Local Institution - 0133 Cluj-Napoca, | |
| Local Institution - 0137 Avellino, | |
| Local Institution - 0140 London, London, City of | |
| Local Institution - 0142 Pembroke Pines, Florida | |
| Local Institution - 0153 Chicago, Illinois | |
| Local Institution - 0154 Orange, California | |
| Local Institution - 0158 New York, New York | |
| Local Institution - 0161 Auderghem, Bruxelles-Capitale, Région de | |
| Local Institution - 0162 Bron, Rhône | |
| Local Institution - 0163 Harderwijk, Gelderland | |
| Local Institution - 0164 Amsterdam, North Holland | |
| Local Institution - 0170 Saint-Herblain, Loire-Atlantique | |
| Local Institution - 0171 Portland, Oregon | |
| Local Institution - 0173 San Antonio, Texas | |
| Local Institution - 0175 Madrid, Madrid, Comunidad de | |
| Local Institution - 0176 Madrid, Madrid, Comunidad de | |
| Local Institution - 0177 Barcelona, Catalunya [Cataluña] | |
| Local Institution - 0178 Málaga, | |
| Local Institution - 0179 Zaragoza, | |
| Local Institution - 0180 Valencia, | |
| Local Institution - 0181 Majadahonda, Madrid, Comunidad de | |
| Local Institution - 0182 Seville, | |
| Local Institution - 0184 Chicoutimi, Quebec | |
| Local Institution - 0185 Montreal, Quebec | |
| Local Institution - 0189 Bellinzona, | |
| Local Institution - 0190 Calgary, Alberta | |
| Local Institution - 0191 Kashiwa, Chiba | |
| Local Institution - 0192 Sendai, Miyagi | |
| Local Institution - 0193 Yokohama, Kanagawa | |
| Local Institution - 0194 Ina-machi, Saitama | |
| Local Institution - 0195 Nagaizumi-cho,Sunto-gun, Shizuoka | |
| Local Institution - 0196 Nagoya, Aichi-ken | |
| Local Institution - 0197 Hamamatsu, Shizuoka | |
| Local Institution - 0198 Hirakata, Osaka | |
| Local Institution - 0199 Nishinomiya, Hyōgo | |
| Local Institution - 0200 Kurashiki, Okayama-ken | |
| Local Institution - 0201 Kurume, Fukuoka | |
| Local Institution - 0202 Koto-ku, Tokyo | |
| Local Institution - 0203 Tōon, Ehime | |
| Local Institution - 0204 Ōsaka-sayama, Osaka | |
| Local Institution - 0206 Madrid, Madrid, Comunidad de | |
| Local Institution - 0207 Esslingen am Neckar, Baden-Wurttemberg | |
| Local Institution - 0208 Chemnitz, Saxony | |
| Local Institution - 0209 Oldenburg, Lower Saxony | |
| Local Institution - 0210 Heidelberg, | |
| Local Institution - 0211 Berlin, | |
| Local Institution - 0212 Stuttgart, Baden-Wurttemberg | |
| Local Institution - 0213 Cologne, North Rhine-Westphalia | |
| Local Institution - 0215 Gauting, | |
| Local Institution - 0216 Amsterdam, North Holland | |
| Local Institution - 0217 Sapporo, Hokkaido | |
| Local Institution - 0218 Barcelona, Barcelona [Barcelona] | |
| Local Institution - 0219 Bydgoszcz, | |
| Local Institution - 0220 Lublin, Lublin Voivodeship | |
| Local Institution - 0222 Chihuahua City, | |
| Local Institution - 0223 Mexico City, | |
| Local Institution - 0224 Oaxaca City, Oaxaca | |
| Local Institution - 0225 Mexico City, Mexico City | |
| Local Institution - 0226 Cali, Valle del Cauca Department | |
| Local Institution - 0227 Montería, Departamento de Córdoba | |
| Local Institution - 0228 Bogotá, Cundinamarca | |
| Local Institution - 0229 Valledupar, Cesar Department | |
| Local Institution - 0231 Gdynia, Pomeranian Voivodeship | |
| Local Institution - 0236 Donauwörth, Bavaria | |
| Local Institution - 0238 Esslingen am Neckar, Baden-Wurttemberg | |
| Local Institution - 0239 Kassel, | |
| Local Institution - 0241 Ulm, | |
| Local Institution - 0242 Hamburg, | |
| Local Institution - 0244 Beijing, Beijing Municipality | |
| Local Institution - 0246 Changchun, Jilin | |
| Local Institution - 0247 Nanchang, Jiangxi | |
| Local Institution - 0248 Jinan, Shandong | |
| Local Institution - 0249 Shanghai, | |
| Local Institution - 0250 Shanghai, Shanghai Municipality | |
| Local Institution - 0251 Linhai, Zhejiang | |
| Local Institution - 0252 Hangzhou, Zhejiang | |
| Local Institution - 0255 Changsha, Hunan | |
| Local Institution - 0256 Xuzhou, Jiangsu | |
| Local Institution - 0257 Shenyang, Liaoning | |
| Local Institution - 0259 Chongqing, Chongqing Municipality | |
| Local Institution - 0260 Nanning, | |
| Local Institution - 0261 Luoyang, Henan | |
| Local Institution - 0262 Singapore, | |
| Local Institution - 0263 Singapore, | |
| Local Institution - 0264 Bangkok, | |
| Local Institution - 0265 Bangkok, Bangkok | |
| Local Institution - 0266 Songkhla, | |
| Local Institution - 0267 Jingzhou, Hubei | |
| Local Institution - 0268 Chattanooga, Tennessee | |
| Local Institution - 0271 Anyang, Henan | |
| Local Institution - 0272 Mueng, Changwat Khon Kaen | |
| Local Institution - 0274 Kiel, Schleswig-Holstein | |
| Local Institution - 0277 Candiolo, Torino | |
| Local Institution - 0278 Nantes, | |
| Local Institution - 0279 Irvine, California | |
| Local Institution - 0280 Wilrijk, Antwerpen | |
| Local Institution - 0281 Sulton, Surrey, | |
| Local Institution - 0284 Columbus, Ohio | |
| NYU Langone Health New York, New York | |
| National Cheng Kung University Hospital Tainan, | |
| National Taiwan University Hospital Taipei, | |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island Mineola, New York | |
| Piedmont Healthcare Atlanta, Georgia | |
| Princess Margaret Cancer Centre Toronto, Ontario | |
| Providence Cancer Institute Franz Clinic Portland, Oregon | |
| Providence St. Vincent Medical Center Portland, Oregon | |
| Renown Regional Medical Center Reno, Nevada | |
| Rochester General Hospital Infectious Disease Rochester, New York | |
| Shanxi Cancer Hospital Taiyuan, Shanxi | |
| Shaw Cancer Center Edwards, Colorado | |
| Taichung Veterans General Hospital Taichung, | |
| Taipei Medical University Hospital New Taipei City, | |
| Taipei Veterans General Hospital Taipei, | |
| Tennessee Oncology Nashville, Tennessee | |
| Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology Wuhan, Hubei | |
| University Hospitals Cleveland Medical Center Cleveland, Ohio | |
| University of Virginia Health System Charlottesville, Virginia | |
| Virginia Commonwealth University (VCU) Richmond, Virginia | |
| Washington University School of Medicine St Louis, Missouri |
Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
Pfizer CT.gov Call Center - ClinicalTrials.gov_Inquiries@pfizer.com
NCT07227298
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Inclusion Criteria:
* Pathologically confirmed locally advanced (Stage IIIB/IIIC) or metastatic (Stage IV) squamous or non-squamous NSCLC and are not a candidate for complete surgical resection and curative concurrent/sequential chemoradiotherapy
* PD-L1 status available
* Part B only: PD-L1 ≥ TPS 1%
* Measurable disease based on RECIST v1.1 per investigator.
* Eastern Cooperative Oncology Group performance status of 0 or 1.
* Adequate organ function
Exclusion Criteria:
* Participants with known AGAs including EGFR, ALK and ROS1, NTRK, BRAF, and MET
* History of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy
* Known active CNS lesions, including brainstem, meningeal, or spinal cord metastases or compression
* Leptomeningeal disease
* Active autoimmune diseases requiring systemic treatment within the past 2 years
* Previous systemic anti-tumor therapy for locally advanced, unresectable, or metastatic NSCLC
* Previous treatment with immunotherapy (exception is (neo)adjuvant anti-PD-(L)1), ADCs containing MMAE payload, systemic anti-angiogenic therapy, or prior radiotherapy to the lung within 6 months of first dose of study intervention BIOLOGICAL: PF-08634404, BIOLOGICAL: Sigvotatug Vedotin, BIOLOGICAL: Combination Agent 1
Advanced/Metastatic Non-Small Cell Lung Cancer, Carcinoma, Non-Small Cell Lung, Non-small Cell Lung Cancer
non-small cell lung cancer, NSCLC, advanced solid tumors, metastatic non-small cell lung cancer, locally advanced non-small cell lung cancer, squamous non-small cell lung cancer, non-squamous non-small cell lung cancer
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Show 32 locations
Study Locations
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| Location | Contacts |
|---|---|
| BRCR Global - Tamarac Tamarac, Florida | |
| BRCR Global Puerto Rico - Hato Rey San Juan, | |
| BRCR Medical Center Inc. Coral Springs, Florida | |
| Dallas Cancer Specialists Garland, Texas | |
| Highlands Oncology Group, PA Springdale, Arkansas | |
| Highlands Oncology Group, PA Springdale, Arkansas | |
| Highlands Oncology Group, PA Springdale, Arkansas | |
| Kansai Medical University Hospital Hirakata, Osaka | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung City, | |
| Lumi Research Houston, Texas | |
| Mackay Memorial Hospital Taipei, | |
| Massey Cancer Center Clinical & Translational Research Lab Richmond, Virginia | |
| National Cheng Kung University Hospital Tainan, | |
| National Taiwan University Hospital Taipei, | |
| Oncology Associates of Oregon, P.C. Eugene, Oregon | |
| Pan American Center for Oncology Trials, LLC Rio Piedras, | |
| Providence Medical Foundation Fullerton, California | |
| Providence St. Jude Medical Center Fullerton, California | |
| Providence St. Jude Medical Center - Virginia K. Crosson Cancer Center and Infusion Center Fullerton, California | |
| Rocky Mountain Cancer Centers, LLP Denver, Colorado | |
| Shizuoka Cancer Center Nakatogari, Shizuoka | |
| Southwest Oncology Associates Houston, Texas | |
| Taipei Veterans General Hospital Taipei, | |
| US Oncology Investigational Products Center (IPC) Irving, Texas | |
| VCU Health Community Memorial Hospital South Hill, Virginia | |
| VCU Health Stony Point Richmond, Virginia | |
| VCU Health Tappahannock Hospital Tappahannock, Virginia | |
| VCU Medical Center Gateway Building Richmond, Virginia | |
| Virginia Commonwealth University Richmond, Virginia | |
| Virginia Commonwealth University Richmond, Virginia | |
| Voyage Clinical Sugar Land, Texas | |
| mid Florida hematology and Oncology Center Orange City, Florida |