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13 Study Matches

Colorectal Health Research Champions

Contact(s):

Hunley, Rachel - rachel.hunley@vcuhealth.org

Principal Investigator: Sheppard, Vanessa, B.

System ID: NCT04812743

IRB Number: HM20017398

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Interventions: Behavioral: Colorectal Health Research Champions

Conditions: Cancer of Colon, Cancer of Rectum, Rectum, Colon

Keywords: Prevention

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Location	Contacts
Virginia Commonwealth University Richmond, Virginia	Katelyn Schifano, MS - (schifanokr@vcu.edu)

Phase 3 Study of MRTX849 +Cetuximab vs Chemo in Patients W/ Advanced Colorectal Cancer w/ KRAS G12C

Contact(s):

Donovan, Carrie - cdonovan2@vcu.edu

Principal Investigator: Matin, Khalid

System ID: NCT04793958

IRB Number: HM20022574

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Interventions: Drug: MRTX849, Biological: Cetuximab, Drug: mFOLFOX6 Regimen, Drug: FOLFIRI Regimen, drug: Mrtx849, drug: Leucovorin, drug: Folinic acid, drug: Cetuximab, drug: 5-fluorouracil

Conditions: Advanced Colorectal Cancer, Metastatic Colorectal Cancer, Rectum, Colon

Keywords: Colorectal Cancer, Colorectal Cancer Trial, Colorectal Carcinoma, Rectal Cancer, Colon Cancer, KRAS, KRAS G12C, RAS, Colorectal Adenocarcinoma

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Study Locations

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Location	Contacts
AdventHealth Cancer Institute Orlando, Florida
Alabama Oncology, Bruno Cancer Center Birmingham, Alabama
Baylor Scott & White Medical Center Round Rock, Texas
Cancer Partners of Nebraska Lincoln, Nebraska
Cleveland Clinic Florida Weston, Florida
Community Cancer Institute Clovis, California
Compass Oncology- Vancouver Cancer Center Vancouver, Washington
Comprehensive Blood and Cancer Center - Bakersfield Bakersfield, California
Comprehensive Cancer Centers of Nevada Las Vegas, Nevada
Comprehensive Hematology Oncology St. Petersburg, Florida
Eastern CT Hematology and Oncology Associates Norwich, Connecticut
Emad Ibrahim, MD, Inc. Redlands, California
Florida Cancer Affiliates- Ocala Ocala, Florida
Florida Cancer Specialists Nashville, Tennessee
Florida Cancer Specialists Nashville, Tennessee
Florida Cancer Specialists Nashville, Tennessee
Florida Cancer Specialists (Administration and Drug Shipment) Saint Petersburg, Florida
Fundaci?n de Investigaci?n de Diego (FDI) Clinical Research San Juan,
Hematology Oncology Associates of Fredericksburg Fredericksburg, Virginia
Henry Ford Hospital Detroit, Michigan
Highlands Oncology Group Springdale, Arkansas
Inova Schar Cancer Institute Fairfax, Virginia
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health New York, New York
Massachusetts General Hospital Boston, Massachusetts
Mayo Clinic Rochester, Minnesota
Mayo Clinic Rochester, Minnesota
Mayo Clinic Building - Phoenix Phoenix, Arizona
Memorial Sloan Kettering Cancer Center - New York New York, New York
Mercy Clinic Cancer & Hematology - Chub O'Reilly Cancer Center Springfield, Missouri
Midwestern Regional Medical Center, Inc. DBA CTCA, Chicago Zion, Illinois
Millennium Physicians - North Houston Houston, Texas
MultiCare Regional Cancer Center - Tacoma Puyallup, Washington
New Jersey Cancer Center and Blood Disorders Belleville, New Jersey
North Shore Hematology and Oncology Assoc. P.C. DBA NY Cancer and Blood Specialists Port Jefferson Station, New York
Olive View - University of California Los Angeles Medical Center Sylmar, California
Orlando Health Cancer Institute Orlando, Florida
Pacific Hematology Oncology Associates San Francisco, California
Puerto Rico Medical Research Center Hato Rey,
Regions Hospital - Cancer Care Center Saint Paul, Minnesota
Rocky Mountain Cancer Centers Denver, Colorado
Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey
SCRI - Hematology Oncology Clinic - Baton Rouge Baton Rouge, Louisiana
SCRI - Tennessee Oncology - Chattanooga - Memorial Plaza Chattanooga, Tennessee
SCRI Tennessee Oncology Nashville Centennial Nashville, Tennessee
Sharp Memorial Hospital San Diego, California
Southeastern Regional Medical Center, Inc. DBA Cancer Treatment Centers of America Newnan, Georgia
St. Francis Cancer Center Indianapolis, Indiana
St. Joseph Heritage Healthcare Fullerton, California
Summit Medical Group Berkeley Heights, New Jersey
Sylvester Comprehensive Cancer Center Plantation, Florida
TRIO-US Central Administration Whittier, California
Texas Oncology- Baylor Charles A. Sammons Cancer Center Dallas, Texas
The University of Texas MD Anderson Cancer Center Houston, Texas
Torrance Memorial Physician Network - Cancer Care and Infusion Center Torrance, California
USC/Norris Comprehensive Cancer Center Los Angeles, California
University of Colorado Hospital Anschutz Cancer Pavilion Aurora, Colorado
University of Oklahoma Health Sciences Center - OU Health Stephenson Cancer Center Oklahoma City, Oklahoma
Virginia Cancer Institute Richmond, Virginia
Virginia Commonwealth University Richmond, Virginia	Donovan, Carrie - (cdonovan2@vcu.edu)
Virginia Commonwealth University, Massey Cancer Center Richmond, Virginia
Western Regional Medical Center, Inc. DBA Cancer Treatment Centers of America, Phoenix Goodyear, Arizona
Winship Cancer Institute Atlanta, Georgia

Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer

Contact(s):

ctrrecruit@vcu.edu

Principal Investigator:

System ID: NCT06102902

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Inclusion Criteria:

* Patients must have histologically confirmed and radiographically measurable metastatic colorectal adenocarcinoma with known BRAF V600E mutation, confirmed in a Clinical Laboratory Improvement Amendments (CLIA) certified laboratory with at least one tumor measurable as defined by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, and for which standard curative or palliative measures do not exist or are no longer effective * Age ≥ 18 years. Because no dosing or adverse event data are currently available on the use of ZEN003694 in combination with cetuximab and encorafenib in patients \< 18 years of age, children are excluded from this study * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (Karnofsky ≥ 60%) * Absolute neutrophil count ≥ 1,500/mcL * Platelets ≥ 100,000/mcL * Hemoglobin (Hb) ≥ 9 mg/dl * Total bilirubin ≤ 1.5 mg/dl (excluding Gilbert's disease) * Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) ≤ 3 x institutional upper limit of normal (ULN) * Creatinine clearance (CrCL) glomerular filtration rate (GFR) ≥ 50 mL/min/1.73 m\^2 * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated * Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load * Patients with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression * Patients with new or progressive brain metastases (active brain metastases) or leptomeningeal disease are eligible if the treating physician determines that immediate CNS specific treatment is not required and is unlikely to be required during the first cycle of therapy * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. Patients should be New York Heart Association Functional Classification of class II or better * Patients must have progressed after at least 1 prior systemic treatment for incurable advanced or metastatic disease * Patients must have received prior treatment with the combination of encorafenib and cetuximab. They must have tolerated the combination at doses planned for the study * The effects of ZEN003694 on the developing human fetus are unknown. For this reason and because BRD and BET inhibitor agents as well as other therapeutic agents used in this trial are known to be teratogenic, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for at least 4 months following the last dose of study drug. Women must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin \[HCG\]) within 72 hours prior to the start of investigational product. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately * Ability to understand and the willingness to sign a written informed consent document. Legally authorized representatives may sign and give informed consent on behalf of study participants

Exclusion Criteria:

* Patients who have not recovered from adverse events due to prior anti-cancer therapy (i.e., have residual toxicities \> grade 1) with the exception of alopecia * Patients who are receiving any other investigational agents * History of allergic reactions attributed to compounds of similar chemical or biologic composition to ZEN003694 or other agents used in study * Patients with uncontrolled intercurrent illness including, but not limited to, active bleeding diatheses, poorly controlled infection/disorders, or nonmalignant medical illnesses that are uncontrolled or whose control may be jeopardized by the treatment with the study therapy * Patients receiving any medications or substances that are strong inhibitors or inducers of CYP3A4 or substrates of CYP1A2 with narrow therapeutic windows are ineligible. Strong inhibitors or inducers of CYP3A4 must be discontinued at least 7 days prior to the first dose of ZEN003694. As proton pump inhibitors (PPIs), H2 receptor antagonists, and antacids may alter the pharmacokinetics of ZEN003694 by reducing ZEN003694 exposure, patients receiving proton pump inhibitors are ineligible. If H2 blockers or other acid reducing agents are used concomitantly with ZEN003694, a staggered dosing schedule should be used, either dose ZEN003694 2 hours before the H2 blocker or 10-12 hours after an H2 blocker. Because the lists of these agents are constantly changing, it is important to regularly consult a frequently-updated medical reference. As part of the enrollment/informed consent procedures, the patient will be counseled on the risk of interactions with other agents, and what to do if new medications need to be prescribed or if the patient is considering a new over-the-counter medicine or herbal product * Pregnant women are excluded from this study because ZEN003694 is BRD and BET inhibitor agent with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with ZEN003694, breastfeeding should be discontinued if the mother is treated with ZEN003694. These potential risks may also apply to other agents used in this study

Interventions: DRUG: BET Bromodomain Inhibitor ZEN-3694, PROCEDURE: Biopsy Procedure, PROCEDURE: Biospecimen Collection, BIOLOGICAL: Cetuximab, PROCEDURE: Computed Tomography, PROCEDURE: Echocardiography Test, DRUG: Encorafenib, PROCEDURE: Magnetic Resonance Imaging, PROCEDURE: Multigated Acquisition Scan

Conditions: Metastatic Colorectal Adenocarcinoma, Recurrent Colorectal Adenocarcinoma, Refractory Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8

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Location	Contacts
Los Angeles General Medical Center Los Angeles, California
M D Anderson Cancer Center Houston, Texas	Site Public Contact - (askmdanderson@mdanderson.org)
Ochsner Medical Center Jefferson New Orleans, Louisiana	Site Public Contact - (Elisemarie.curry@ochsner.org)
Ohio State University Comprehensive Cancer Center Columbus, Ohio	Site Public Contact - (Jamesline@osumc.edu)
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California	Site Public Contact - (ucstudy@uci.edu)
UCHealth University of Colorado Hospital Aurora, Colorado
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine, California	Site Public Contact - (ucstudy@uci.edu)
USC / Norris Comprehensive Cancer Center Los Angeles, California
University of Kansas Cancer Center Kansas City, Kansas	Site Public Contact - (KUCC_Navigation@kumc.edu)
University of Kansas Clinical Research Center Fairway, Kansas	Site Public Contact - (KUCC_Navigation@kumc.edu)
University of Kansas Hospital-Indian Creek Campus Overland Park, Kansas	Site Public Contact - (KUCC_Navigation@kumc.edu)
University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas	Site Public Contact - (KUCC_Navigation@kumc.edu)
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma	Site Public Contact - (ou-clinical-trials@ouhsc.edu)
University of Virginia Cancer Center Charlottesville, Virginia	Site Public Contact - (uvacancertrials@hscmail.mcc.virginia.edu)
VCU Massey Comprehensive Cancer Center Richmond, Virginia	Site Public Contact - (CTOclinops@vcu.edu)

A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer

Contact(s):

Takeda Contact - medinfoUS@takeda.com

Principal Investigator:

System ID: NCT06562543

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Inclusion Criteria:

• Provide written (or electronic) informed consent.
• Male or female aged more than or equal to (≥)18 years.
• Presence of histologically and/or cytologically documented metastatic colorectal adenocarcinoma. Rat sarcoma virus (RAS) status for each participant must be documented.
• Have been previously treated with standard approved therapies: * Fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, * An anti-vascular endothelial growth factor (VEGF) biological therapy (e.g., bevacizumab, aflibercept, ramucirumab \[regorafenib is NOT an anti-VEGF biologic\]), and * If RAS wild-type and medically appropriate, an anti-epidermal growth factor receptor (EGFR) therapy (e.g., cetuximab, panitumumab). * If known microsatellite instability-high (MSI-H) or deficient mismatch repair (dMMR) tumor and medically appropriate, a programmed cell death protein 1 (PD1) inhibitor.
• Self-identify as Black and/or African American or Hispanic and/or Latino or as both.
• Body weight ≥40 kilograms (kg).
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 at screening.
• Have assessable disease according to RECIST version 1.1, assessed locally.
• In participants of childbearing potential, agreement to use highly effective form(s) of contraception, which results in a low failure rate (less than \[\<\]1 percent \[%\] per year) when used consistently and correctly, starting during the screening period, continuing throughout the entire trial period, and for 2 weeks after taking the last dose of the trial intervention. Such methods include oral (PO) hormonal contraception (combined estrogen/progestogen or progestogen-only) associated with inhibition of ovulation, intrauterine device, intrauterine hormone-releasing system (IUS), bilateral tubal ligation, vasectomized partner, or true sexual abstinence in line with the preferred and usual lifestyle of the participant. Those assigned male sex at birth must always use a condom.

Exclusion Criteria:

• Absolute neutrophil count (ANC) \<1.5 times 10\^9 per liter (10\^9/L), platelet count \<100 times 10\^9/L, or hemoglobin \<9.0 grams per deciliter (g/dL). Blood transfusion within 1 week prior to enrollment for the purpose of increasing the likelihood of eligibility is not allowed.
• Serum total bilirubin more than (\>)1.5 times the upper limit of normal range (ULN). Participants with previously documented Gilbert syndrome and bilirubin \<2 times ULN are eligible.
• Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2.5 times ULN in participants without hepatic metastases; ALT or AST \>5 times ULN in participants with hepatic metastases.
• Creatinine clearance \<30 milliliters per minute (mL/min). Creatinine clearance can either be measured in a 24-hour urine collection or estimated by the Cockcroft-Gault equation. Where available and appropriate, other formulae may be used to estimate clearance after consultation with the trial medical monitor.
• Urine dipstick or urinalysis with protein ≥2 positive or 24-hour urine protein ≥1.0 gram per 24 hours (g/24 hours). Participants with 1+ positive proteinuria must undergo a 24-hour urine collection to assess urine protein level.
• Uncontrolled hypertension, defined as systolic BP ≥140 millimeter of mercury (mmHg) and/or diastolic blood pressure (BP) ≥90 mmHg despite optimal medical management. The participant must have BP below both limits. Repeated assessments are permitted.
• International normalized ratio (INR) \>1.5 times ULN or activated partial thromboplastin time (aPTT) \>1.5 times ULN, unless the participant is currently receiving or intended to receive anticoagulants for prophylactic purposes.
• History of or active gastric/duodenal ulcer or ulcerative colitis, active hemorrhage of an unresected gastrointestinal tumor, history of perforation or fistulas, or any other condition that could, in the investigator's judgment, result in gastrointestinal hemorrhage or perforation within the 6 months prior to screening.
• History or presence of hemorrhage from any other site (e.g, hemoptysis or hematemesis) within 2 months prior to screening.
• History of a thromboembolic event, including deep vein thrombosis, pulmonary embolism, or arterial embolism within 6 months prior to screening.
• Stroke and/or transient ischemic attack within 12 months prior to screening.
• Clinically significant cardiovascular disease, including but not limited to, acute myocardial infarction or coronary artery bypass surgery within 6 months prior to enrollment, severe or unstable angina pectoris, New York Heart Association Class III/IV congestive heart failure, ventricular arrhythmias requiring treatment, or left ventricular ejection fraction \<50% by echocardiogram.
• QT interval, corrected using the Fridericia method (QTcF) \>480 milliseconds or any factors that increase the risk of QT interval, corrected based on the patient's heart rate (QTc) prolongation or risk of arrhythmic events such as hypokalemia, congenital long QT syndrome, or family history of long QT syndrome.
• Systemic antineoplastic therapies (except for that described in exclusion criterion no. 15) or any investigational therapy within 2 weeks prior to the first dose of the trial intervention, including chemotherapy, radical radiotherapy, hormonotherapy, biotherapy, and immunotherapy.
• Systemic small molecule targeted therapies (e.g., tyrosine kinase inhibitors \[TKIs\]) within 5 half-lives or 4 weeks (whichever is shorter) prior to the first dose of the trial intervention.
• Palliative radiotherapy for bone metastasis/lesion within 2 weeks prior to the initiation of the trial intervention.
• Brachytherapy (i.e., implantation of radioactive seeds) within 60 days prior to the first dose of the trial intervention.
• Surgery or invasive procedure (i.e., a procedure that includes a biopsy; central venous catheter placement is allowed) within 14 days prior to the first dose of the trial intervention or unhealed surgical incision.
• Any unresolved toxicities from previous antitumor treatments greater than NCI CTCAE, version 5.0, Grade 1 (except for alopecia or neurotoxicity Grade less than or equal to \[≤\]2).
• Known human immunodeficiency virus infection.
• Known history of active viral hepatitis. For participants with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load had to be undetectable on suppressive therapy, if indicated. Participants with hepatitis C virus (HCV) infection who are currently on treatment are eligible if they have an undetectable HCV viral load.
• Clinically uncontrolled active infection requiring intravenous (IV) antibiotics.
• Tumor invasion of a large vascular structure (e.g., pulmonary artery or superior or inferior vena cava).
• Those who are currently pregnant or lactating.
• Brain metastases and/or spinal cord compression untreated with surgery and/or radiotherapy, and without clinical imaging evidence of SD for 14 days or longer; participants requiring steroids within 4 weeks prior to the start of the trial intervention are to be excluded.
• Other malignancy, except for non-melanoma skin cancer, in situ cervical carcinoma, or bladder carcinoma (tumor in situ and T1) that had been adequately treated during the 5 years prior to screening. Participants with another primary malignancy that has been adequately treated may be included after consultation with the trial medical monitor.
• Inability to take medication PO, dysphagia, or an active gastric ulcer resulting from previous surgery (e.g., gastric bypass) or a severe gastrointestinal disease, or any other condition that investigators believe might affect absorption of the investigational medicinal product (IMP).
• Other disease, metabolic disorder, physical examination anomaly, abnormal laboratory result, or any other condition (e.g., current alcohol or drug abuse) that investigators suspect might prohibit use of the IMP, affect interpretation of trial results, or put the participant at undue risk of harm based on the investigator's assessment.
• Known hypersensitivity to fruquintinib or any of its inactive ingredients, including the azo dyes Tartrazine- Federal Food, Drug, and Cosmetic Act (FD\&C) Yellow 5 and Sunset yellow For Coloring Food (FCF)-FD\&C Yellow 6.
• Received prior fruquintinib.
• Live vaccine ≤28 days before the first dose of the trial intervention. Seasonal vaccines for influenza are generally inactivated vaccines and are allowed. Intranasal vaccines are live vaccines and are not allowed.
• Use of strong inducers of cytochrome P450 3A4 (CYP3A4) within 2 weeks before the first dose of the trial intervention.

Interventions: DRUG: Fruquintinib

Conditions: Colorectal Cancer

Keywords: colorectal cancer, fruquintinib

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Location	Contacts
Albert Einstein College of Medicine The Bronx, New York
BRCR Global Plantation, Florida
Baptist Health - Miami Cancer Institute Miami, Florida
Baylor College of Medicine Houston, Texas	Site Contact - (karen.riggins@bcm.edu)
Boston Medical Center Boston, Massachusetts
Capital Health Medical Center - Hopewell Pennington, New Jersey	Site Contact - (ALoaiza-Bonilla@capitalhealth.org)
Central Alabama Research Birmingham, Alabama	Site Contact - (kashraf@centralalabamaresearch.com)
Christiana Care Health Services Newark, Delaware	Site Contact - (jmisleh@cbg.org)
Columbia University New York, New York
Emory University Atlanta, Georgia	Site Contact - (olatunji.alese@emory.edu)
Fox Chase Cancer Center \| Philadelphia, PA Philadelphia, Pennsylvania
Fundacion de Investigacion de Diego (FDI Clinical Research) San Juan,	Site Contact - (macosta@fdipr.com)
Hattiesburg Clinic Hattiesburg, Mississippi	Site Contact - (bo.hrom@hattiesburgclinic.com)
Hightower Clinical Research Oklahoma City, Oklahoma	Site Contact - (lam@hightowerclinical.com)
Hope and Healing Cancer Services Hinsdale, Illinois	Site Contact - (sgundala@hopenheal.care)
Indiana University Indianapolis, Indiana	Site Contact - (aalhader@iu.edu)
Ironwood Cancer and Research Centers Chandler, Arizona	Site Contact - (dharia@ironwoodcrc.com)
James J Peters Veterans Administration Medical Center - NAVREF The Bronx, New York
Jefferson Health Philadelphia, Pennsylvania	Site Contact - (Atrayee.BasuMallick@jefferson.edu)
Medical University of South Carolina Charleston, South Carolina
Medstar Speciality Hospital Northwest, Washington	Site Contact - (marcus.s.noel@gunet.georgetown.edu)
Mercy Medical Center Baltimore, Maryland	Site Contact - (pledakis@mdmercy.com)
Midwest Oncology Associates - Kansas City Kansas City, Missouri	Site Contact - (jaswinder.singh@amrllc.com)
Oncology Consultants - Memorial City Location Houston, Texas	Site Contact - (jpeguero@OncologyConsultants.com)
Our Lady of the Lake Physician Group - LSU Health Baton Rouge Oncology Baton Rouge, Louisiana	Site Contact - (stagg.patrick@yahoo.com)
PIH Health Whittier Hospital Downey, California	Site Contact - (Andrew.Pham@pihhealth.org)
Renovatio Clinical The Woodlands, Texas	Site Contact - (mary.crow@renovatioclinical.com)
Renovatio Clinical The Woodlands, Texas	Site Contact - (jonathan.lu@renovatioclinical.com)
SSM Health St. Louis DePaul Hospital St Louis, Missouri	Site Contact - (brian.smith@ssmhealth.com)
Saint Luke's Cancer Institute Kansas City, Missouri
Tranquil Research Webster, Texas	Site Contact - (drknecht@cls.health)
UC Irvine Medical Center - Chao Family Comprehensive Cancer Orange, Virginia	Site Contact - (fdayyani@uci.edu)
University of Alabama at Birmingham Birmingham, Alabama	Site Contact - (ggupta@uabmc.edu)
University of Arizona Tucson, Arizona	Site Contact - (ajscott@arizona.edu)
University of California San Diego San Diego, California	Site Contact - (gbotta@ucsd.edu)
University of Florida Gainesville, Florida	Site Contact - (thomas.george@medicine.ufl.edu)
University of Miami Miami, Florida
University of Southern California Los Angeles, California	Site Contact - (algaze@usc.edu)
University of Tennessee -- Memphis Memphis, Tennessee	Site Contact - (schokshi@uthsc.edu)
University of Texas Southwestern Medical Center Dallas, Texas	Site Contact - (Nilesh.Verma@UTSouthwestern.edu)
Vanderbilt University Medical Center Nashville, Tennessee	Site Contact - (brooke.d.looney@vumc.org)
Virginia Commonwealth University Richmond, Virginia	Site Contact - (khalid.matin@vcuhealth.org)
Washington University School of Medicine St Louis, Missouri	Site Contact - (nikolaos@wustl.edu)
Willis Knighton Cancer Center Shreveport, Louisiana	Site Contact - (jfeagin@wkhs.com)
Zangmeister Cancer Center Columbus, Ohio	Site Contact - (smikhail@zangcenter.com)

Addition of Antibiotics to Upfront Treatment Regimen for Colorectal Cancer

Contact(s):

Massey IIT Research Operations - masseyepd@vcu.edu

Principal Investigator:

System ID: NCT06728072

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Inclusion Criteria:

* Diagnosis of stage IV colorectal cancer * Measurable disease by Response evaluation criteria in solid tumors (RECIST) 1.1 criteria * Planned first-line treatment with a 5FU-based doublet chemotherapy regimen for colon cancer, specifics of the regimen at the discretion of the treating physician Note: Patients who have received adjuvant therapy \>6 months prior are eligible * Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2 * Absolute neutrophil count (ANC) ≥1,500 cells/μL * Platelet count ≥100,000 cells/μL * Hemoglobin ≥8 g/dL Note: The use of transfusion or other intervention to achieve hemoglobin ≥8 g/dL is acceptable. * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 × upper limit of normal (ULN) Note: Patients with documented liver metastases: AST and ALT ≤5 × ULN * Serum creatinine ≤1.5 x ULN or calculated creatinine clearance ≥40 mL/min using the Cockcroft-Gault equation: (140 - age) × body weight/plasma creatinine × 72 (× 0.85 if female) * Radiographically measurable disease by RECIST 1.1 * Nonpregnant and not actively breastfeeding * Sexually active patients of childbearing potential and their partners must agree to use medically acceptable form of contraception, per treating investigator, throughout the study Patients should continue to use medically acceptable methods of contraception after study treatment ends, following the guidance for their specific chemotherapy regimen. Childbearing potential excludes: Age \> 50 years and naturally amenorrhoeic for \> 1 year OR previous hysterectomy or bilateral salpingo-oophorectomy * Patients on a pre-existing daily aspirin regimen may participate in the study without interrupting this regimen. * Patients with a contraindication to aspirin may participate in the study. These patients will not be required to take aspirin as part of the study treatment.

Exclusion Criteria:

* Total colectomy * Diagnosed with Cockayne Syndrome * Using disulfiram, tizanidine, or theophylline and unable to stop taking these medications for the length of the microbiome modulation therapy * On methotrexate doses of 15 mg/week or more * History of allergic reaction to ciprofloxacin, metronidazole, or aspirin * Fuss course of antibiotics in the 30 days before chemotherapy start Note: Full course is defined as ≥5 doses with an intent to treat a defined infection. Use of antibiotics intended for prophylaxis at the time of surgery is allowed * Corrected QT interval (QTc) \>480 on baseline ECG * Diagnosed with a malabsorptive syndrome * Inability to swallow tablets

Interventions: DRUG: Standard of Care Chemotherapy + Metronidazole, ciprofloxacin, aspirin

Conditions: Colorectal Cancer, CRC

Keywords: Colorectal Cancer, CRC

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Location	Contacts
Virginia Commonwealth University Richmond, Virginia	Massey CTO GI Team - (masseygi@vcu.edu)

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

Contact(s):

ctrrecruit@vcu.edu

Principal Investigator:

System ID: NCT07018869

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Inclusion Criteria:

* PATIENTS: * Patient participants must have newly diagnosed surgically resected, stage II or stage III colorectal cancer per the timing described below * Patient participants must have an adult in their life who supports them in their colorectal cancer journey who they might be willing to invite to join them in viewing an educational website. This is determined via the question: "Do you have an adult in your life, such as a spouse/partner, family member or friend, who supports you with your colorectal cancer journey and may be willing to view a website with you? When we say, "supports you in your colorectal cancer journey", we mean things like, helping you keep and get to medical appointments, talking with you and/or your doctors about your cancer, or helping you make decisions about your cancer." * Those who respond "no" to the question above will be told that "Because this study is for patients and a supporter to view the website together, you are not eligible for this study, but there may be other studies you are eligible for in the future". * NOTE: The above question will be used to define "supporter" for purposes of this study. Examples of supporters include a spouse, partner, sibling, adult child, another family member, or friend. * NOTE: The supporter does not have to agree to participate in the study in order for the patient to be eligible for this study. Justification for requiring the enrolled patient to have a supporter (whether the supporter is invited or participates) is based on the study's underlying conceptual framework * Patient participants must not have recurrent or metastatic (stage IV) colorectal cancer * Patient participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the efficacy assessment of this intervention * Patient participants must be registered within 90 - 180 days of surgical resection * Patient participants must be ≥ 18 years of age at the time of registration/randomization. The lower cutoff of 18 was determined because the lower age range of patients that may be recruited to Southwest Oncology Group (SWOG) studies is 18 * Patient participants must have Zubrod performance status of 0-2 * Patient participants must be able to read English or Spanish since the website for the intervention and control arm are available in English and Spanish * Patient participants must: 1) be able to complete Patient Reported Outcome (PRO) questionnaires in English or Spanish, and 2) agree to complete PROs at all scheduled timepoints * Patient participants will be encouraged to provide an email address or cell phone number, if possible, for the purpose of being contacted by staff at the University of Michigan who will provide access to the educational website. For those who do not wish to provide or create an email address or a cell phone number, they may still participate with alternate methods * Patient participants must not be enrolled or be planning to enroll in a clinical trial of investigational treatment that includes imaging and/or laboratory monitoring for the duration of this trial * NOTE: Patient participants are allowed to be co-enrolled on other non-treatment clinical trials * SUPPORTER PARTICIPANT: * Supporter participants must be ≥ 18 years of age at the time of registration/randomization * Supporter participants must be able to read English or Spanish since the educational website is available in English and Spanish * Supporter participants must have been identified by the patient as a person who may be willing to join them in reviewing the educational website * PATIENT AND SUPPORTER: * NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system * Patient and supporter participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines. This protocol does not permit use of Legally Authorized Representative

Interventions: OTHER: Intervention website access, OTHER: Control website access, OTHER: Interview, OTHER: Questionnaire Administration

Conditions: Colorectal Cancer Stage II, Colorectal Cancer Stage III

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Location	Contacts
Abbott-Northwestern Hospital Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Alaska Breast Care and Surgery LLC Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Alaska Oncology and Hematology LLC Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Alaska Women's Cancer Care Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Alegent Health Bergan Mercy Medical Center Omaha, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Alegent Health Immanuel Medical Center Omaha, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Alegent Health Lakeside Hospital Omaha, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Anchorage Associates in Radiation Medicine Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Annie Penn Memorial Hospital Reidsville, North Carolina	Site Public Contact - (stacey.phelps@conehealth.com)
Augusta University Medical Center Augusta, Georgia	Site Public Contact - (ga_cares@augusta.edu)
BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri
Bay Area Hospital Coos Bay, Oregon	Site Public Contact - (cherie.cox@bayareahospital.org)
Beacon Kalamazoo Kalamazoo, Michigan
Beacon Kalamazoo Cancer Center Kalamazoo, Michigan
Beebe Health Campus Rehoboth Beach, Delaware	Site Public Contact - (research@beebehealthcare.org)
Beebe Medical Center Lewes, Delaware	Site Public Contact - (research@beebehealthcare.org)
Beebe South Coastal Health Campus Millville, Delaware	Site Public Contact - (research@beebehealthcare.org)
Benefis Helena Specialty Center Helena, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Benefis Sletten Cancer Institute Great Falls, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Bethesda North Hospital Cincinnati, Ohio	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Billings Clinic Cancer Center Billings, Montana	Site Public Contact - (research@billingsclinic.org)
Billings Clinic-Cody Cody, Wyoming	Site Public Contact - (research@billingsclinic.org)
Bozeman Health Deaconess Hospital Bozeman, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Broadlawns Medical Center Des Moines, Iowa
Bronson Battle Creek Battle Creek, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Bronson Methodist Hospital Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
CARTI Cancer center Little Rock, Arkansas	Site Public Contact - (Research@CARTI.com)
CHI Health Good Samaritan Kearney, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
CHI Health Saint Francis Grand Island, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Cancer Care Center of O'Fallon O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Care Northwest - Spokane South Spokane, Washington	Site Public Contact - (research@ccnw.net)
Cancer Care Northwest-North Spokane Spokane, Washington	Site Public Contact - (research@ccnw.net)
Cancer Care Northwest-Valley Spokane, Washington	Site Public Contact - (research@ccnw.net)
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Center at Saint Joseph's Phoenix, Arizona	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Cancer Center of Western Wisconsin New Richmond, Wisconsin	Site Public Contact - (mmcorc@healthpartners.com)
Cancer Center-Metro Medical Center Bayamon Bayamón,
Cancer Hematology Centers - Flint Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan	Site Public Contact - (connie.szczepanek@crcwm.org)
Carilion Roanoke Memorial Hospital Roanoke, Virginia
Carle BroMenn Medical Center Normal, Illinois	Site Public Contact - (Research@Carle.com)
Carle Cancer Center Urbana, Illinois	Site Public Contact - (Research@carle.com)
Carle Cancer Institute Normal Normal, Illinois	Site Public Contact - (Research@Carle.com)
Carle Physician Group-Effingham Effingham, Illinois	Site Public Contact - (Research@carle.com)
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois	Site Public Contact - (Research@carle.com)
Carle at The Riverfront Danville, Illinois	Site Public Contact - (Research@Carle.com)
Centra Alan B Pearson Regional Cancer Center Lynchburg, Virginia	Site Public Contact - (Kevin.Patel@centrahealth.com)
Central Care Cancer Center - Bolivar Bolivar, Missouri	Site Public Contact - (aroland@kccop.org)
Central Care Cancer Center - Garden City Garden City, Kansas	Site Public Contact - (aroland@kccop.org)
Central Care Cancer Center - Great Bend Great Bend, Kansas	Site Public Contact - (aroland@kccop.org)
Centralia Oncology Clinic Centralia, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Centro Comprensivo de Cancer de UPR San Juan,	Site Public Contact - (ctsucontact@westat.com)
Chelsea Hospital Chelsea, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Christiana Care - Union Hospital Elkton, Maryland	Site Public Contact - (frank.crum@christianacare.org)
Christiana Care Health System-Christiana Hospital Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Christiana Care Health System-Concord Health Center Chadds Ford, Pennsylvania	Site Public Contact - (lbarone@christianacare.org)
Christiana Care Health System-Wilmington Hospital Wilmington, Delaware	Site Public Contact - (lbarone@christianacare.org)
Clackamas Radiation Oncology Center Clackamas, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
CommonSpirit Cancer Center Mercy Durango, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Commonwealth Cancer Center-Corbin Corbin, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Community Hospital of Anaconda Anaconda, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Community Medical Center Missoula, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Cone Health Cancer Center Greensboro, North Carolina	Site Public Contact - (stacey.phelps@conehealth.com)
Cone Health Cancer Center at Alamance Regional Burlington, North Carolina	Site Public Contact - (stacey.phelps@conehealth.com)
Cone Health Cancer Center at Drawbridge Parkway Greensboro, North Carolina	Site Public Contact - (stacey.phelps@conehealth.com)
Cone Health MedCenter Asheboro Asheboro, North Carolina	Site Public Contact - (stacey.phelps@conehealth.com)
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Lakeland Hospitals - Niles Hospital Niles, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Corewell Health Reed City Hospital Reed City, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Cox Cancer Center Branson Branson, Missouri
CoxHealth South Hospital Springfield, Missouri
Creighton University Medical Center Omaha, Nebraska	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Crossroads Cancer Center Effingham, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Decatur Memorial Hospital Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Doctors Cancer Center Manati,
Duluth Clinic Ashland Ashland, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - Baxter Clinic Baxter, Minnesota
Essentia Health - Deer River Clinic Deer River, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - Ely Clinic Ely, Minnesota
Essentia Health - Fosston Fosston, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - International Falls Clinic International Falls, Minnesota
Essentia Health - Jamestown Clinic Jamestown, North Dakota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - Moose Lake Clinic Moose Lake, Minnesota
Essentia Health - Park Rapids Park Rapids, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health - Saint Joseph's Crosslake Clinic Crosslake, Minnesota
Essentia Health - Saint Joseph's Pequot Lakes Clinic Pequot Lakes, Minnesota
Essentia Health - Saint Joseph's Pine River Clinic Pine River, Minnesota
Essentia Health - Saint Joseph's Staples Clinic Staples, Minnesota
Essentia Health Cancer Center Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Hibbing Clinic Hibbing, Minnesota
Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Saint Mary's Hospital - Superior Superior, Wisconsin
Essentia Health Saint Mary's Medical Center Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Sandstone Sandstone, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health Virginia Clinic Virginia, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health-Hayward Clinic Hayward, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Essentia Health-Spooner Clinic Spooner, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
FHP Health Center-Guam Tamuning,
Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Lakes Medical Center Wyoming, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Northland Medical Center Princeton, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Southdale Hospital Edina, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Flaget Memorial Hospital Bardstown, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Freeman Health System Joplin, Missouri	Site Public Contact - (LJCrockett@freemanhealth.com)
Genesee Hematology Oncology PC Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Genesys Hurley Cancer Institute Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Gibbs Cancer Center-Gaffney Gaffney, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
Gibbs Cancer Center-Pelham Greer, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
Good Samaritan Hospital - Cincinnati Cincinnati, Ohio	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Great Falls Clinic Great Falls, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Greater Regional Medical Center Creston, Iowa
HSHS Saint Elizabeth's Hospital O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Harold Alfond Center for Cancer Care Augusta, Maine
Hawaii Cancer Care - Westridge ‘Aiea, Hawaii	Site Public Contact - (info@hawaiicancercare.com)
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii	Site Public Contact - (i.webster@hawaiicancercare.com)
Heartland Regional Medical Center Saint Joseph, Missouri	Site Public Contact - (Trisha.England2@mymlc.com)
Helen F Graham Cancer Center Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Hematology Oncology Consultants-Clarkston Clarkston, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Hennepin County Medical Center Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Henry Ford Health Saint John Hospital Detroit, Michigan	Site Public Contact - (Kkeenan1@hfhs.org)
Henry Ford Health Warren Hospital Warren, Michigan	Site Public Contact - (kforman1@hfhs.org)
Henry Ford Madison Heights Hospital - Breast Warren, Michigan	Site Public Contact - (kforman1@hfhs.org)
Henry Ford River District Hospital East China Township, Michigan	Site Public Contact - (kforman1@hfhs.org)
Henry Ford Saint John Hospital - Academic Grosse Pointe Woods, Michigan	Site Public Contact - (kforman1@hfhs.org)
Henry Ford Saint John Hospital - Breast Grosse Pointe Woods, Michigan	Site Public Contact - (karen.forman@ascension.org)
Henry Ford Saint John Hospital - Macomb Medical Macomb, Michigan	Site Public Contact - (kforman1@hfhs.org)
Henry Ford Saint John Hospital - Van Elslander Grosse Pointe Woods, Michigan	Site Public Contact - (kforman1@hfhs.org)
Henry Ford Warren Hospital - Breast Macomb Macomb, Michigan	Site Public Contact - (kforman1@hfhs.org)
Henry Ford Warren Hospital - GLCMS Warren, Michigan	Site Public Contact - (kforman1@hfhs.org)
Hi-Line Sletten Cancer Center Havre, Montana	Site Public Contact - (protocols@swog.org)
Holy Cross Hospital Fort Lauderdale, Florida	Site Public Contact - (eileen.georgi@holy-cross.com)
Hope Cancer Center Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Hurley Medical Center Flint, Michigan	Site Public Contact - (wstrong@ghci.org)
Huron Gastroenterology PC Ypsilanti, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Idaho Urologic Institute-Meridian Meridian, Idaho	Site Public Contact - (stephanie.couch@stjoeshealth.org)
Illinois CancerCare - Washington Washington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Bloomington Bloomington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Canton Canton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Carthage Carthage, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Dixon Dixon, Illinois
Illinois CancerCare-Eureka Eureka, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Galesburg Galesburg, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Macomb Macomb, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Pekin Pekin, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peoria Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peru Peru, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Princeton Princeton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Iowa Methodist Medical Center Des Moines, Iowa
Kadlec Clinic Hematology and Oncology Kennewick, Washington	Site Public Contact - (research@kadlecmed.org)
Kapiolani Medical Center for Women and Children Honolulu, Hawaii
Katmai Oncology Group Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
LSU Health Sciences Center at Shreveport Shreveport, Louisiana	Site Public Contact - (LPost@lsuhsc.edu)
Lake Regional Hospital Osage Beach, Missouri	Site Public Contact - (clinicaltrials@lakeregional.com)
Lakeview Hospital Stillwater, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Hazleton Hazleton, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Logan Health Medical Center Kalispell, Montana	Site Public Contact - (mccinfo@mtcancer.org)
Longmont United Hospital Longmont, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
MaineHealth Cancer Care Center of York County Sanford, Maine
MaineHealth Cancer Care and IV Therapy - Brunswick Brunswick, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
MaineHealth Cancer Care and IV Therapy - Sanford Sanford, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
MaineHealth Cancer Care and IV Therapy - South Portland South Portland, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
MaineHealth LincolnHealth Hospital Damariscotta, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
MaineHealth Waldo Hospital Belfast, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
Margaret R Pardee Memorial Hospital Hendersonville, North Carolina	Site Public Contact - (pardeecancerresearch@unchealth.unc.edu)
Medical Oncology Hematology Consultants PA Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Medical University of South Carolina Charleston, South Carolina	Site Public Contact - (hcc-clinical-trials@musc.edu)
Memorial Health University Medical Center Savannah, Georgia	Site Public Contact - (Lorraine.OHara@hcahealthcare.com)
Memorial Hospital of Carbondale Carbondale, Illinois	Site Public Contact - (clinical.research@sih.net)
Memorial Hospital of Laramie County Cheyenne, Wyoming	Site Public Contact - (protocols@swog.org)
Mercy Cancer Center Merced, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Cape Girardeau Cape Girardeau, Missouri
Mercy Cancer Center - Carmichael Carmichael, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Elk Grove Elk Grove, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Rocklin Rocklin, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Sacramento Sacramento, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center-West Lakes Clive, Iowa
Mercy Clinic-Rolla-Cancer and Hematology Rolla, Missouri
Mercy Hospital Cedar Rapids, Iowa
Mercy Hospital Cedar Rapids, Iowa	Site Public Contact - (mmcorc@healthpartners.com)
Mercy Hospital Fort Smith Fort Smith, Arkansas
Mercy Hospital Joplin Joplin, Missouri	Site Public Contact - (esmeralda.carrillo@mercy.net)
Mercy Hospital Oklahoma City Oklahoma City, Oklahoma
Mercy Hospital Pittsburg Pittsburg, Kansas
Mercy Hospital Saint Louis St Louis, Missouri
Mercy Hospital South St Louis, Missouri	Site Public Contact - (Danielle.Werle@mercy.net)
Mercy Hospital Springfield Springfield, Missouri
Mercy Hospital Washington Washington, Missouri
Mercy Infusion Center - Chippewa St Louis, Missouri
Mercy Medical Center Baltimore, Maryland	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Medical Center - Des Moines Des Moines, Iowa
Mercy Medical Center-West Lakes West Des Moines, Iowa
Mercy Oncology and Hematology - Clayton-Clarkson Ballwin, Missouri
Mercy San Juan Medical Center Carmichael, California	Site Public Contact - (OncologyResearch@DignityHealth.org)
Methodist Medical Center of Illinois Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Michigan Healthcare Professionals Pontiac Pontiac, Michigan	Site Public Contact - (Emily.Crofts@trinity-health.org)
Miller-Dwan Hospital Duluth, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Minnesota Oncology - Burnsville Burnsville, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Mission Hope Medical Oncology - Santa Maria Santa Maria, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Missouri Baptist Medical Center St Louis, Missouri
Missouri Baptist Sullivan Hospital Sullivan, Missouri
Monticello Cancer Center Monticello, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Munson Medical Center Traverse City, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
MyMichigan Medical Center Alpena Alpena, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Gladwin Gladwin, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Gratiot Alma, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Midland Midland, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Mount Pleasant Mount Pleasant, Michigan	Site Public Contact - (CVResearch@mymichigan.org)
MyMichigan Medical Center Saginaw Saginaw, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
MyMichigan Medical Center Tawas Tawas City, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York, New York	Site Public Contact - (cancerclinicaltrials@cumc.columbia.edu)
New Ulm Medical Center New Ulm, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Newland Medical Associates-Clarkston Clarkston, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Newland Medical Associates-Pontiac Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
North Memorial Medical Health Center Robbinsdale, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Northeast Georgia Medical Center Braselton Braselton, Georgia	Site Public Contact - (cancerpatient.navigator@nghs.com)
Northeast Georgia Medical Center-Gainesville Gainesville, Georgia	Site Public Contact - (cancerpatient.navigator@nghs.com)
Northwest Wisconsin Cancer Center Ashland, Wisconsin	Site Public Contact - (CancerTrials@EssentiaHealth.org)
OSF Saint Anthony's Health Center Alton, Illinois
OSF Saint Francis Hospital and Medical Group Escanaba, Michigan	Site Public Contact - (WI_research_admin@hshs.org)
Ochsner LSU Health Monroe Medical Center Monroe, Louisiana	Site Public Contact - (LPost@lsuhsc.edu)
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa
PROncology San Juan,	Site Public Contact - (info@PRoncology.com)
Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Pali Momi Medical Center ‘Aiea, Hawaii
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Parkland Health Center - Farmington Farmington, Missouri
PeaceHealth Saint John Medical Center Longview, Washington	Site Public Contact - (kmakin-bond@peacehealth.org)
PeaceHealth Saint Joseph Medical Center Bellingham, Washington	Site Public Contact - (achapman1@peacehealth.org)
PeaceHealth Southwest Medical Center Vancouver, Washington	Site Public Contact - (kmakin-bond@peacehealth.org)
PeaceHealth United General Medical Center Sedro-Woolley, Washington	Site Public Contact - (achapman1@peacehealth.org)
Penobscot Bay Medical Center Rockport, Maine	Site Public Contact - (clinicalresearch@mainehealth.org)
Penrose-Saint Francis Healthcare Colorado Springs, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Phelps Health Delbert Day Cancer Institute Rolla, Missouri	Site Public Contact - (research@phelpshealth.org)
Physicians' Clinic of Iowa PC Cedar Rapids, Iowa
Pocono Medical Center East Stroudsburg, Pennsylvania	Site Public Contact - (Morgan_M.Horton@lvhn.org)
Prisma Health Cancer Institute - Butternut Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Easley Easley, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Eastside Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Faris Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Greer Greer, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Seneca Seneca, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Providence Alaska Medical Center Anchorage, Alaska	Site Public Contact - (AKPAMC.OncologyResearchSupport@providence.org)
Providence Hood River Memorial Hospital Hood River, Oregon	Site Public Contact - (canrsrchstudies@provdience.org)
Providence Medical Foundation - Santa Rosa Santa Rosa, California
Providence Newberg Medical Center Newberg, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Portland Medical Center Portland, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Queen of The Valley Napa, California
Providence Regional Cancer Partnership Everett, Washington	Site Public Contact - (marilyn.birchman@providence.org)
Providence Regional Cancer System-Aberdeen Aberdeen, Washington	Site Public Contact - (deidre.dillon@providence.org)
Providence Regional Cancer System-Centralia Centralia, Washington	Site Public Contact - (deidre.dillon@providence.org)
Providence Regional Cancer System-Lacey Lacey, Washington	Site Public Contact - (deidre.dillon@providence.org)
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank, California	Site Public Contact - (Najee.Boucher@providence.org)
Providence Saint Mary Regional Cancer Center Walla Walla, Washington	Site Public Contact - (Cheryl.Dodd@providence.org)
Providence Saint Vincent Medical Center Portland, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Santa Rosa Memorial Hospital Santa Rosa, California
Providence Willamette Falls Medical Center Oregon City, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Puerto Rico Hematology Oncology Group Bayamón,
Queen's Cancer Cenrer - POB I Honolulu, Hawaii
Queen's Cancer Center - Kuakini Honolulu, Hawaii
Queen's Medical Center Honolulu, Hawaii
Ralph H Johnson VA Medical Center Charleston, South Carolina	Site Public Contact - (ashley.salvo@va.gov)
Regional Cancer Center-Lee Memorial Health System Fort Myers, Florida	Site Public Contact - (protocols@swog.org)
Regions Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Rice Memorial Hospital Willmar, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Ridgeview Medical Center Waconia, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Riverwood Healthcare Center Aitkin, Minnesota	Site Public Contact - (CancerTrials@EssentiaHealth.org)
Rocky Mountain Cancer Centers-Penrose Colorado Springs, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
SIH Cancer Institute Carterville, Illinois	Site Public Contact - (clinical.research@sih.net)
SMC Center for Hematology Oncology Union Union, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
SSM Health Good Samaritan Mount Vernon, Illinois	Site Public Contact - (gayla.hall@ssmhealth.com)
Saint Alphonsus Cancer Care Center-Baker City Baker City, Oregon	Site Public Contact - (mccinfo@mtcancer.org)
Saint Alphonsus Cancer Care Center-Boise Boise, Idaho	Site Public Contact - (stephanie.couch@stjoeshealth.org)
Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho	Site Public Contact - (stephanie.couch@stjoeshealth.org)
Saint Alphonsus Cancer Care Center-Nampa Nampa, Idaho	Site Public Contact - (mccinfo@mtcancer.org)
Saint Alphonsus Cancer Care Center-Ontario Ontario, Oregon	Site Public Contact - (mccinfo@mtcancer.org)
Saint Anthony Hospital Lakewood, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Anthony North Hospital Westminster, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Anthony Regional Hospital Carroll, Iowa	Site Public Contact - (sbenson@iora.org)
Saint Charles Health System Bend, Oregon	Site Public Contact - (nosall@stcharleshealthcare.org)
Saint Charles Health System-Redmond Redmond, Oregon
Saint Francis Cancer Center Greenville, South Carolina	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Francis Cancer Center Greenville, South Carolina	Site Public Contact - (Heather_Rich@bshsi.org)
Saint Francis Hospital Greenville, South Carolina	Site Public Contact - (Heather_Rich@bshsi.org)
Saint Francis Medical Center Cape Girardeau, Missouri	Site Public Contact - (sfmc@sfmc.net)
Saint Francis Regional Medical Center Shakopee, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Saint John's Hospital - Healtheast Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Saint Joseph Hospital Nashua, New Hampshire	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph Hospital East Lexington, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph London London, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph Mount Sterling Mount Sterling, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph Radiation Oncology Resource Center Lexington, Kentucky	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph's Medical Center Stockton, California
Saint Luke's Cancer Institute - Boise Boise, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Fruitland Fruitland, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Meridian Meridian, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Nampa Nampa, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Luke's Cancer Institute - Twin Falls Twin Falls, Idaho	Site Public Contact - (eslinget@slhs.org)
Saint Mary Corwin Medical Center Pueblo, Colorado	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Mary's Hospital Centralia, Illinois
Saint Michael Cancer Center Silverdale, Washington	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Saint Patrick Hospital - Community Hospital Missoula, Montana	Site Public Contact - (amy.hanneman@providence.org)
Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin	Site Public Contact - (WI_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls, Wisconsin	Site Public Contact - (WI_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri
San Juan City Hospital San Juan,
San Juan Community Oncology Group San Juan,
Schulze Family Foundation Cancer Clinic - Bonita Health Center Bonita Springs, Florida	Site Public Contact - (RCCR@leehealth.org)
Self Regional Healthcare Greenwood, South Carolina	Site Public Contact - (nmcgaha@selfregional.org)
Sheboygan Physicians Group Sheboygan, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Skagit Regional Health Cancer Care Center Mount Vernon, Washington	Site Public Contact - (rcccclinicalresearch@skagitvalleyhospital.org)
Southern Illinois University School of Medicine Springfield, Illinois
Sovah Health Martinsville Martinsville, Virginia	Site Public Contact - (sharon.hubbard@lpnt.net)
Spartanburg Medical Center Spartanburg, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
Springfield Clinic Springfield, Illinois
Springfield Memorial Hospital Springfield, Illinois	Site Public Contact - (pallante.beth@mhsil.com)
Straub Clinic and Hospital Honolulu, Hawaii
Straub Pearlridge Clinic ‘Aiea, Hawaii
Swedish Cancer Institute-Edmonds Edmonds, Washington	Site Public Contact - (PCRC-NCORP@Swedish.org)
Swedish Cancer Institute-Issaquah Issaquah, Washington	Site Public Contact - (PCRC-NCORP@Swedish.org)
Swedish Medical Center-Ballard Campus Seattle, Washington	Site Public Contact - (PCRC-NCORP@Swedish.org)
Swedish Medical Center-Cherry Hill Seattle, Washington	Site Public Contact - (PCRC-NCORP@Swedish.org)
Swedish Medical Center-First Hill Seattle, Washington	Site Public Contact - (PCRC-NCORP@Swedish.org)
Tamarack Health Hayward Medical Center Hayward, Wisconsin
The Iowa Clinic PC West Des Moines, Iowa
The Longstreet Clinic - Gainesville Gainesville, Georgia
The Queen's Medical Center - West Oahu ‘Ewa Beach, Hawaii	Site Public Contact - (rohta@queens.org)
ThedaCare Cancer Care - New London New London, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Oshkosh Oshkosh, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Shawano Shawano, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Waupaca Waupaca, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Regional Cancer Center Appleton, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
ThedaCare Regional Medical Center - Neenah Neenah, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
Tidelands Georgetown Memorial Hospital Georgetown, South Carolina	Site Public Contact - (broe@tidelandshealth.org)
TriHealth Cancer Institute-Anderson Cincinnati, Ohio	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
TriHealth Cancer Institute-Westside Cincinnati, Ohio	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)
Trinity Health Grand Rapids Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Trinity Health IHA - Obstetrics and Gynecology West Arbor Ann Arbor, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Medical Center - Brighton Brighton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Medical Center - Canton Canton, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Muskegon Hospital Muskegon, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan	Site Public Contact - (MCRCwebsitecontactform@stjoeshealth.org)
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa
UI Healthcare Mission Cancer and Blood - Fort Dodge Fort Dodge, Iowa	Site Public Contact - (trials@missioncancer.com)
UI Healthcare Mission Cancer and Blood - Pella Pella, Iowa	Site Public Contact - (trials@missioncancer.com)
United Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
University of Hawaii Cancer Center Honolulu, Hawaii
University of Michigan Health - Sparrow Lansing Lansing, Michigan	Site Public Contact - (harsha.trivedi@umhsparrow.org)
University of Michigan Health - West Wyoming, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
VCU Community Memorial Health Center South Hill, Virginia	Site Public Contact - (nemer.elmouallem@vcuhealth.org)
VCU Massey Cancer Center at Stony Point Richmond, Virginia	Site Public Contact - (ctoclinops@vcu.edu)
VCU Massey Comprehensive Cancer Center Richmond, Virginia	Site Public Contact - (CTOclinops@vcu.edu)
Valley Radiation Oncology Peru, Illinois
Virginia Cancer Institute Richmond, Virginia	Site Public Contact - (smoore@vacancer.com)
West Michigan Cancer Center Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Woodland Memorial Hospital Woodland, California	Site Public Contact - (ResearchInstituteInquiries@CommonSpirit.org)

A Study of Nivolumab-relatlimab Fixed-dose Combination Versus Regorafenib or TAS-102 in Participants With Later-lines of Metastatic Colorectal Cancer (RELATIVITY-123)

Contact(s):

BMS Study Connect Contact Center www.BMSStudyConnect.com - Clinical.Trials@bms.com

Principal Investigator:

System ID: NCT05328908

Show full eligibility criteria

Inclusion Criteria:

• Histological confirmed previously treated colorectal cancer with adenocarcinoma histology with metastatic or recurrent unresectable disease at study entry
• Participants must have:
• progressed during or within approximately 3 months following the last administration of approved standard therapies (at least 1, but not more than 4 prior lines of therapies), which must include a fluoropyrimidine, oxaliplatin, irinotecan, an anti-VEGF therapy, and anti-EGFR therapy (if KRAS wild-type), if available in the respective country, or;
• been intolerant to prior systemic chemotherapy regimens if there is documented evidence of clinically significant intolerance despite adequate supportive measures
• Must have sufficient tumor tissue & evaluable PD-L1 expression to meet the study requirements
• Must have measurable disease per RECIST v1.1. Participants with lesions in a previously irradiated field as the sole site of measurable disease will be permitted to enroll provided the lesion(s) have demonstrated clear progression and can be measured accurately

Exclusion Criteria:

• Prior treatment with either an immunotherapy or with regorafenib or with TAS-102
• Untreated central nervous system (CNS) metastases, participants are eligible if CNS metastases have been treated and participants have neurologically returned to baseline (except for residual signs or symptoms related to the CNS treatment)
• History of refractory hypertension not controlled with anti-hypertensive therapy, myocarditis (regardless of etiology), uncontrolled arrhythmias, acute coronary syndrome within 6 months prior to dosing, Class II congestive heart failure (as per the New York Heart Association Functional Classification), interstitial lung disease/pneumonitis or an active, known or suspected autoimmune disease
• Confirmed tumor microsatellite instable high/deficient mismatch repair (MSI-H/dMMR) status as per local standard testing; MSI/MMR test results from initial diagnosis are acceptable. Other protocol-defined inclusion/exclusion criteria apply

Interventions: Drug: Nivolumab-relatlimab FDC, Drug: Regorafenib, Drug: TAS-102

Conditions: Colorectal Neoplasms

Keywords: Micro-satellite Stable (MSS) Metastatic Colorectal Cancer (mCRC), Relatlimab, Nivolumab, BMS-986213, Regorafenib, Stivarga, Lonsurf

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Show 156 locations

Study Locations

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Location	Contacts
Astera Cancer Care East Brunswick, New Jersey	Phillip Reid, Site 0043
Baptist Hospital of Miami Miami, Florida	Antonio Ucar, Site 0025
Charleston Hematology Oncology Associates (CHOA) Charleston, South Carolina	David Ellison, Site 0008
City of Hope Duarte, California
Duke University Medical Center Durham, North Carolina	Michael Morse, Site 0009
Eastern Connecticut Hematology and Oncology (ECHO) Norwich, Connecticut	Dennis Slater, Site 0117
Fort Wayne Medical Oncology and Hematology Fort Wayne, Indiana	Sunil Babu, Site 0081
Fox Chase Cancer Center Philadelphia, Pennsylvania	Namrata Vijayvergia, Site 0147
Good Samaritan Hospital Corvallis, Oregon	David Draper, Site 0082
Highlands Oncology Group - Springdale Springdale, Arkansas	J.Thaddeus Beck, Site 0044
Local Institution - 0001 Lenexa, Kansas	Site 0001
Local Institution - 0002 London,
Local Institution - 0003 Oakland, California	Site 0003
Local Institution - 0004 ABB, Buenos Aires F.D.	Site 0004
Local Institution - 0007 Santiago, Santiago Metropolitan	Site 0007
Local Institution - 0010 Lille, Hauts-de-France	Site 0010
Local Institution - 0014 Strasbourg, Alsace	Site 0014
Local Institution - 0015 Paris,	Site 0015
Local Institution - 0016 Lima, LIM	Site 0016
Local Institution - 0017 Toulouse, Haute-Garonne	Site 0017
Local Institution - 0018 La Tronche, Isère	Site 0018
Local Institution - 0019 Villejuif, Val-de-Marne	Site 0019
Local Institution - 0020 Badalona, Barcelona	Site 0020
Local Institution - 0021 La Jolla, California	Site 0021
Local Institution - 0022 Yvoir, Namur
Local Institution - 0023 Ghent, Oost-Vlaanderen	Site 0023
Local Institution - 0024 Sint-Niklaas, Oost-Vlaanderen	Site 0024
Local Institution - 0026 New York, New York	Site 0026
Local Institution - 0027 New Orleans, Louisiana	Site 0027
Local Institution - 0028 Ravenna, Emilia-Romagna	Site 0028
Local Institution - 0029 Parma,	Site 0029
Local Institution - 0030 Beijing, Beijing Municipality	Site 0030
Local Institution - 0033 Wenzhou, Zhejiang	Site 0033
Local Institution - 0034 Naples,	Site 0034
Local Institution - 0035 New York, New York	Site 0035
Local Institution - 0036 Aviano, Friuli Venezia Giulia	Site 0036
Local Institution - 0037 Portland, Oregon	Site 0037
Local Institution - 0038 Portland, Oregon	Site 0038
Local Institution - 0039 Zuerich,	Site 0039
Local Institution - 0040 Evanston, Illinois	Site 0040
Local Institution - 0041 St.Gallen, HE	Site 0041
Local Institution - 0045 Seoul, Seoul-teukbyeolsi [Seoul]	Site 0045
Local Institution - 0046 Suwon, Kyǒnggi-do	Site 0046
Local Institution - 0050 Grand Rapids, Michigan	Site 0050
Local Institution - 0051 Sevilla, MZ	Site 0051
Local Institution - 0052 Mainz, Rheinland-Pfalz	Site 0052
Local Institution - 0053 Burlington, Ontario	Site 0053
Local Institution - 0054 Athens, Attikí	Site 0054
Local Institution - 0055 Lima,	Site 0055
Local Institution - 0056 Thessaloniki, Kentrikí Makedonía	Site 0056
Local Institution - 0057 Hannover,	Site 0057
Local Institution - 0058 Chicago, Illinois	Site 0058
Local Institution - 0059 Los Angeles, California	Site 0059
Local Institution - 0060 Chaïdári, Attikí	Site 0060
Local Institution - 0061 London, Kensington and Chelsea	Site 0061
Local Institution - 0062 Thessaloniki, Thessaloníki	Site 0062
Local Institution - 0063 Brno, JM
Local Institution - 0064 Praha 5, Prague	Site 0064
Local Institution - 0066 Massillon, Ohio	Site 0066
Local Institution - 0067 Hackensack, New Jersey	Site 0067
Local Institution - 0068 Seoul, Seoul-teukbyeolsi [Seoul]	Site 0068
Local Institution - 0069 Bengaluru, Karnataka	Site 0069
Local Institution - 0070 New Delhi, National Capital Territory of Delhi	Site 0070
Local Institution - 0072 Gurugram, Haryana	Site 0072
Local Institution - 0073 Ahmedabad, Gujarat	Site 0073
Local Institution - 0074 Montpellier, Languedoc-Roussillon	Site 0074
Local Institution - 0075 Chengdu, Sichuan	Site 0075
Local Institution - 0076 Villejuif, Val-de-Marne	Site 0076
Local Institution - 0077 Mumbai, Maharashtra	Site 0077
Local Institution - 0078 Howrah, West Bengal	Site 0078
Local Institution - 0080 Iowa City, Iowa	Site 0080
Local Institution - 0083 Ahmedabad, Gujarat	Site 0083
Local Institution - 0084 Strasbourg, Alsace	Site 0084
Local Institution - 0085 Gainesville, Florida	Site 0085
Local Institution - 0086 Linz,	Site 0086
Local Institution - 0087 Richmond, Virginia	Site 0087
Local Institution - 0088 Pittsburgh, Pennsylvania	Site 0088
Local Institution - 0089 Cheongju-si, Chungcheongbuk-do [Chungbuk]	Site 0089
Local Institution - 0090 Bordeaux, Aquitaine	Site 0090
Local Institution - 0091 Victoria, British Columbia	Site 0091
Local Institution - 0092 Seoul, Seoul-teukbyeolsi [Seoul]	Site 0092
Local Institution - 0093 Salamanca,	Site 0093
Local Institution - 0094 Córdoba, Córdoba Province	Site 0094
Local Institution - 0098 Fort Collins, Colorado	Site 0098
Local Institution - 0099 Sherbrooke, Quebec	Site 0099
Local Institution - 0100 Seoul, Seoul-teukbyeolsi [Seoul]	Site 0100
Local Institution - 0101 Erlangen, Bavaria	Site 0101
Local Institution - 0102 Québec, Quebec	Site 0102
Local Institution - 0103 Drammen, Buskerud	Site 0103
Local Institution - 0104 Atlanta, Georgia	Site 0104
Local Institution - 0105 Oslo,	Site 0105
Local Institution - 0106 Bergen, Hordaland	Site 0106
Local Institution - 0107 Wichita, Kansas	Site 0107
Local Institution - 0108 Wuhan, Hubei	Site 0108
Local Institution - 0109 Hefei, Anhui	Site 0109
Local Institution - 0110 Glasgow, Glasgow City	Site 0110
Local Institution - 0111 Qingdao, Shandong	Site 0111
Local Institution - 0112 Toronto, Ontario	Site 0112
Local Institution - 0113 Charlottesville, Virginia	Site 0113
Local Institution - 0114 Busan, Pusan-Kwangyǒkshi	Site 0114
Local Institution - 0115 Bucharest,	Site 0115
Local Institution - 0116 Deagu, Taegu-Kwangyǒkshi	Site 0116
Local Institution - 0118 Sendai, Miyagi	Site 0118
Local Institution - 0119 Iași,	Site 0119
Local Institution - 0120 Bucharest, Bucharest	Site 0120
Local Institution - 0121 Shimotsuga, Tochigi	Site 0121
Local Institution - 0122 Osaka,	Site 0122
Local Institution - 0123 Bucharest, Bucharest	Site 0123
Local Institution - 0124 Iași,	Site 0124
Local Institution - 0125 Ōsaka-sayama, Osaka
Local Institution - 0126 Amagasaki, Hyōgo	Site 0126
Local Institution - 0128 Mexico City, Mexico City	Site 0128
Local Institution - 0129 Bogotá, Distrito Capital De Bogotá	Site 0129
Local Institution - 0131 Busan, Pusan-Kwangyǒkshi	Site 0131
Local Institution - 0133 Cluj-Napoca,
Local Institution - 0134 Chongqing, Chongqing	Site 0134
Local Institution - 0135 Stockholm,	Site 0135
Local Institution - 0136 Buenos Aires,
Local Institution - 0138 Bogota,	Site 0138
Local Institution - 0139 Monterrey, Nuevo León	Site 0139
Local Institution - 0141 Aguascalientes, AGU	Site 0141
Local Institution - 0142 Pembroke Pines, Florida	Site 0142
Local Institution - 0143 Columbus, Georgia	Site 0143
Local Institution - 0144 San Miguel, LIM	Site 0144
Local Institution - 0146 Huaian, Jiangsu	Site 0146
Local Institution - 0148 Katowice,	Site 0148
Local Institution - 0149 Goyang-si, Kyǒnggi-do	Site 0149
Local Institution - 0150 Bursa,	Site 0150
Local Institution - 0151 Guangzhou, Guangdong	Site 0151
Local Institution - 0152 Xian, SN	Site 0152
Local Institution - 0153 Chicago, Illinois	Site 0153
Local Institution - 0155 Ürümqi, Xinjiang	Site 0155
Local Institution - 0156 Piura, PIU	Site 0156
Local Institution - 0157 Valencia, Comunidad Valencia	Site 0157
Local Institution - 0158 New York, New York	Site 0158
Local Institution - 0159 Chengdu Shi,	Site 0159
Local Institution - 0160 Budapest, Pest	Site 0160
Local Institution - 0161 Auderghem, Bruxelles-Capitale, Région de	Site 0161
Local Institution - 0162 Bron, Rhône	Site 0162
Local Institution - 0163 Harderwijk, Gelderland
Massachusetts General Hospital, Boston, Massachusetts	Aparna Parikh, Site 0140
Mayo Clinic in Arizona - Phoenix Phoenix, Arizona
Northside Hospital - Atlanta Atlanta, Georgia	Ioana Bonta, Site 0031
Perelman School of Medicine at the University of Pennsylvania Philadelphia, Pennsylvania
Rush University Medical Center Chicago, Illinois
Sanford Research Sioux Falls, South Dakota	Jonathan Bleeker, Site 0096
St. Luke's Cancer Institute - Boise Boise, Idaho	Dan Zuckerman, Site 0071
Tennessee Oncology Nashville, Tennessee	Meredith Pelster, Site 0127
The Center for Cancer and Blood Disorders Fort Worth, Texas	Henry Xiong, Site 0097
The James Cancer Hospital Columbus, Ohio	Pannaga Malalur, Site 0095
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C Columbus, Ohio	Anne Noonan, Site 0079
Thomas Jefferson University - Clinical Trials Office-Medical Oncology Philadelphia, Pennsylvania	Atrayee Basu-Mallick, Site 0130
USC Norris Comprehensive Cancer Center Los Angeles, California	Heinz-Josef Lenz, Site 0012
University of Michigan - Rogel Cancer Center Ann Arbor, Michigan	John Krauss, Site 0042
University of Wisconsin-Madison - Wisconsin Institutes for Medical Research (WIMR) Madison, Wisconsin	Dustin Deming, Site 0005
Virginia Commonwealth University Massey Cancer Center Richmond, Virginia	Khalid Matin, Site 0132

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy (OrigAMI-3)

Contact(s):

Study Contact - Participate-In-This-Study1@its.jnj.com

Principal Investigator:

System ID: NCT06750094

Show full eligibility criteria

Inclusion Criteria:

* Have histologically or cytologically confirmed adenocarcinoma of the colon or rectum. Participants must have recurrent, unresectable or metastatic disease * Determined to have kirsten rat sarcoma viral oncogene/neuroblastoma RAS viral oncogene homolog (KRAS/NRAS), G12, G13 and v-raf murine sarcoma viral oncogene homolog B (BRAF) V600X (X represents any single amino acid change from the original amino acid) wild type status by local and/or central next-generation sequencing (NGS) testing * Must agree to the submission of fresh or archival tumor tissue post progression from the most recent therapy, if clinically feasible * Have measurable disease according to response evaluation criteria in solid tumors (RECIST) version (v) 1.1 * Have an eastern cooperative oncology group (ECOG) performance status (PS) of 0 or 1 * Participant must have received 1 line of systemic therapy (fluoropyrimidine-based and oxaliplatin-based) for metastatic colorectal cancer (mCRC), with documented radiographic disease progression on or after this line of therapy. Participants can receive anti-VEGF as prior line of therapy

Exclusion Criteria:

* Has medical history of (noninfectious) interstitial lung disease (ILD) /pneumonitis/pulmonary fibrosis or has current ILD/pneumonitis/pulmonary fibrosis, or where suspected ILD/pneumonitis/pulmonary fibrosis cannot be ruled out by imaging at screening * Has known allergies, hypersensitivity, or intolerance to excipients of any of the following: amivantamab, cetuximab or bevacizumab or any component of FOLFIRI * Has a prior or concurrent second malignancy other than the disease under study or one whose natural history or treatment is likely to interfere with any study endpoints of safety or the efficacy of the study treatment(s) * Participant with known mismatch repair deficiency (dMMR)/ high microsatellite instability (MSI-H) status who has not received immunotherapy treatments * Participant with known human epidermal growth factor receptor 2 (HER2)- positive/amplified tumor * Has prior exposure to irinotecan, any agents that target epidermal growth factor receptor (EGFR) or mesenchymal epithelial transition (MET)

Interventions: BIOLOGICAL: Amivantamab, BIOLOGICAL: Cetuximab, BIOLOGICAL: Bevacizumab, DRUG: 5-fluorouracil, DRUG: Leucovorin calcium/Levoleucovorin, DRUG: Irinotecan

Conditions: Colorectal Neoplasms

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Show 234 locations

Study Locations

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Location	Contacts
AZ Groeninge Kortrijk,
AZ Maria Middelares Ghent,
Actualidad Basada en la Investigación del Cáncer Guadalajara,
Adana City Hospital Adana,
AdventHealth Cancer Institute Orlando, Florida
Aichi Cancer Center Nagoya,
Alliance Cancer Specialists at Main Line Penn Wynne, Pennsylvania
Ankara Bilkent Sehir Hastanesi Ankara,
Antoni van Leeuwenhoek Amsterdam,
Arizona Oncology Associates PC NAHOA Prescott, Arizona
Asan Medical Center Seoul,
Asian Institute Of Gastroenterology Hyderabad,
Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia Vitória,
Assuta MC Tel Aviv,
Astera Cancer Care East Brunswick, New Jersey
Azienda Ospedaliero Universitaria Pisana Pisa,
Azienda Sanitaria Universitaria Friuli Centrale ASU FC Udine,
B P Poddar Hospital and Medical research Limited Kolkata,
Bakirkoy Training and Research Hospital Istanbul,
Banner MD Anderson Cancer Center Gilbert, Arizona
Baylor Scott & White Medical Center Round Rock, Texas
Beijing Cancer Hospital Beijing, Beijing Municipality
Beijing Friendship Hospital Capital Medical University Beijing,
Bialostockie Centrum Onkologii im Marii Sklodowskiej Curie w Bialymstoku Bialystok,
Birmingham Heartlands Hospital Birmingham,
CBCC Global Research Bakersfield, California
CHU de Poitiers Poitiers,
COI Centro Oncologico Internacional Tijuana Tijuana,
Cancer And Hematology Centers of Western Michigan PC Grand Rapids, Michigan
Cancer Center Of Kansas Wichita, Kansas
Cancer and Blood Specialty Clinic Los Alamitos, California
Castle Hill Hospital Hull,
Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman Liège,
Centro Oncologico Personalizado Cope S De R L De C V Mexico City,
Centro Oncologico de Chihuahua Chihuahua City,
Centrul Medical Unirea SRL Brasov,
Chang Gung Memorial Hospital Taoyuan County,
Charite Universitatsmedizin Berlin Campus Virchow Klinikum Berlin,
Chiang Mai University Chiang Mai,
Chiba Cancer Center Chiba, Chiba
Christian medical Vellore,
Clinica Univ. de Navarra Pamplona,
Clinica de Oncologie Sf Nectarie Craiova,
Concord Hospital Concord,
Cuidados Oncologicos Querétaro,
Deenanath Mangeshkar Hospital and Research Centre Pune,
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital Ankara,
ETZ TweeSteden Tilburg,
Eastern Connecticut Hematology & Oncology Assoc. Norwich, Connecticut
Erasmus MC Rotterdam, South Holland
Florida Cancer Specialists East West Palm Beach, Florida
Florida Cancer Specialists North Region St. Petersburg, Florida
Florida Cancer Specialists South Fort Myers, Florida
Fox Chase Cancer Center Philadelphia, Pennsylvania
Fred Hutchinson Cancer Research Center Seattle, Washington
Fudan University Shanghai Cancer Center Shanghai, Shanghai Municipality
Fundacao Antonio Prudente A C Camargo Cancer Center São Paulo,
Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base São José do Rio Preto,
Fundacao Pio XII Barretos, São Paulo
Fundação Doutor Amaral Carvalho Jaú,
Fundação Faculdade de Medicina - Instituto do Cancer do Estado de São Paulo São Paulo,
Fundação Universidade de Caxias do Sul Caxias do Sul,
Gabrail Cancer Center Canton, Ohio
Gansu Provincial Cancer Hospital Lanzhou,
Ganzhou Cancer Hospital Ganzhou,
Gazi Universitesi Hastanesi Ankara,
Grady Memorial Hospital Delaware, Ohio
Guangdong Provincial People's Hospital Guangzhou,
Gulhane Egitim ve Arastirma Hastanesi Ankara,
Hadassah Medical Center Jerusalem, Jerusalem
Harbin Medical University Cancer Hospital Harbin, Heilongjiang
Hattiesburg Clinic Hattiesburg, Mississippi
Health Pharma Queretaro SA de CV Querétaro,
Henry Ford Hospital Detroit, Michigan
Highlands Oncology Group Springdale, Arkansas
Hopital Haut Leveque Pessac,
Hosp Univ Vall D Hebron Barcelona,
Hosp. Clinico Univ. de Valencia Valencia,
Hosp. Gral. Univ. Gregorio Marañon Madrid,
Hosp. Univ. 12 de Octubre Madrid,
Hosp. Univ. Ramon Y Cajal Madrid,
Hosp. Virgen Del Rocio Seville,
Hosp. de La Santa Creu I Sant Pau Barcelona,
Hospital Kuala Lumpur Kuala Lumpur,
Hospital Nossa Senhora da Conceicao S A Porto Alegre,
Hospital Pulau Pinang George Town, Pulau Pinang
Hospital Raja Permaisuri Bainun Ipoh,
Hospital Santa Izabel Santa Casa de Misericordia da Bahia Salvador,
Hospital Umum Sarawak Kuching,
Hospital Universitario Dr Jose Eleuterio Gonzalez Nuevo León,
Hubei Cancer Hospital Wuhan,
Huizhou Central People's Hospital Huizhou,
Hunan Cancer Hospital Changsha, Hunan
Illinois CancerCare Bloomington, Illinois
Institut Jules Bordet Anderlecht,
Institut Kanser Negara Clinical Research Center Putrajaya,
Institut Sainte Catherine Avignon,
Instituto Nacional De Cancerologia Bogotá,
Institutul Oncologic 'Prof Dr. Ion Chiricuta' Cluj-Napoca Cluj-Napoca,
Institutul Regional de Oncologie Iasi Iași,
Instytut Centrum Zdrowia Matki Polki Lodz, Łódź Voivodeship
Ironwood Cancer and Research Center Chandler, Arizona
Istituto Clinico Humanitas Rozzano,
Istituto Dei Tumori Di Milano Milan,
Istituto Oncologico Veneto - IRCCS Padova,
Jolimont Haine-St-Paul,
Kaohsiung Medical University Chung Ho Memorial Hospital Kaohsiung City,
Karolinska Universitetssjukhuset Stockholm,
Kindai University Hospital Osaka, Sakai,
Klinikum der Universitaet Muenchen Munich,
Korea University Anam Hospital Seoul,
Krankenhaus NorthWest Frankfurt am Main,
Kyungpook National University Chilgok Hospital Daegu,
Liaoning Cancer Hospital and Institute Shenyang, Liaoning
Linkou Chang Gung Memorial Hospital Taoyuan District,
Los Angeles Cancer Network Los Angeles, California
MD Anderson Cancer Center Houston, Texas
Mahamana Pandit Madan Mohan Malviya Cancer Centre Varanasi,
Markhot Ferenc Oktatokorhaz es Rendelointezet Eger,
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi Istanbul,
Mary Bird Perkins Cancer Center Baton Rouge, Louisiana
Meander Medisch Centrum Amersfoort,
MedStar Franklin Square Medical Center Rosedale, Maryland
Medical College of Wisconsin Milwaukee, Wisconsin
Mission Cancer Blood Waukee, Iowa
Montefiore Einstein Comprehensive Cancer Center The Bronx, New York
Mount Sinai Medical Center Campus Miami Beach, Florida
Mount Vernon Cancer Centre Northwood,
NYU Langone Medical Center NYU Hematology Associates New York, New York
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy Warsaw,
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach Gliwice,
National Cancer Center Hospital Tokyo,
National Cancer Center Hospital East Chiba, Kashiwa,
National Center for Tumor Diseases NCT Heidelberg,
National Cheng Kung University Hospital Tainan,
National Hospital Organization Osaka National Hospital Osaka,
National Taiwan University Hospital Taipei,
Nebraska Cancer Specialists Omaha, Nebraska
Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi Konya,
Neolife Medical Center Bucharest Bucharest,
New York Cancer and Blood Specialists Shirley, New York
Oncocenter Timișoara,
Oregon Health and Science University Portland, Oregon
Osaka International Cancer Institute Osaka, Osaka,
Pan American Center for Oncology Trials LLC San Juan,
Pecsi Tudomanyegyetem Pécs,
Peking University First Hospital Beijing,
Pelican Impex SRL Oradea,
Perlmutter Cancer Center at NYU Long Island Mineola, New York
Piedmont Cancer Institute Atlanta, Georgia
Ponderas Academic Hospital Bucharest,
Prince of Wales Hospital Hong Kong, Hong Kong SAR
Providence Medical Foundation Fullerton, California
Providence Regional Cancer System Lacey, Washington
Queen Elizabeth Hospital Birmingham,
Queen Mary Hospital Hong Kong,
Rabin Medical Center Petah Tikva, Central District
Radboud University Medical Center Nijmegen,
Rajiv Gandhi Cancer Institute And Research Centre Delhi,
Ramathibodi Hospital Bangkok,
Rambam Medical Center Haifa,
Richmond VA Medical Center Richmond, Virginia
Rocky Mountain Cancer Centers Denver, Colorado
Royal Marsden Hospital London,
SCRI Oncology Partners Nashville, Tennessee
SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego Opole,
Safdarjung Hospital New Delhi,
Sahlgrenska Universitetssjukhuset Gasteborg,
Sakarya University Training and Research Hospital Sakarya,
Samsung Medical Center Gangnam-gu,
Scott and White Memorial Hospital Temple, Texas
Seoul National University Hospital Seoul,
Severance Hospital Yonsei University Health System Seoul, Seoul-teukbyeolsi [Seoul]
Sheba Medical Center Ramat Gan, Central District
Shizuoka Cancer Center Shizuoka, Suntou
Siriraj Hospital Bangkok,
Skanes universitetssjukhus Lund,
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein São Paulo,
Songklanagarind Hospital Songkhla,
Spitalul Memorial Baneasa Bucharest,
St Bartholomew's Hospital London,
St James University Hospital Leeds,
St. Bernard's Medical Center Jonesboro, Arkansas
Sun Yat Sen University Cancer Center Guangzhou, Guangdong
Szegedi Tudomanyegyetem Szeged,
Szpital Kliniczny MSWiA z WMCO Olsztyn,
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza Brzozów,
Södersjukhuset Stockholm,
Taichung Veterans General Hospital Taichung,
Taipei Veterans General Hospital Taipei,
Tata Memorial Hospital Mumbai, Maharashtra
Tel Aviv Sourasky Medical Center Tel Aviv,
Tennessee Oncology Nashville, Tennessee
Tennessee Oncology Chattanooga Chattanooga, Tennessee
Texas Oncology - San Antonio San Antonio, Texas
Texas Oncology DFW Dallas, Texas
Texas Oncology West Texas Abilene, Texas
The Cancer Institute Hospital of JFCR Koto-ku, Tokyo
The Catholic University of Korea Seoul St Mary s Hospital Seoul,
The First Affiliated Hospital of NanChang University Nanchang,
The First Bethune Hospital of Jilin University Changchun,
The Second Affiliated Hospital of Zhejiang University Hangzhou,
The Sixth Affiliated Hospital Sun Yat sen University Guangzhou,
The University of Osaka Hospital Suita, Osaka
Thomas Jefferson University Philadelphia, Pennsylvania
Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin Municipality
Torrance Memorial Physicians Network Torrance, California
UCLA Santa Monica, California
USC Norris Comprehensive Cancer Center Los Angeles, California
UT Health East Texas HOPE Cancer Center Tyler, Texas
UT Southwestern Medical Center Dallas, Texas
UZ Antwerpen Edegem,
Universitair Ziekenhuis Leuven Leuven,
University Cancer and Blood Center LLC Athens, Georgia
University College Hospital London,
University Hospital of Cleveland Cleveland, Ohio
University Malaya Medical Centre Lembah Pantai,
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center Pittsburgh, Pennsylvania
University of Colorado Denver Anschultz Medical Campus Aurora, Colorado
University of Michigan Rogel Cancer Center Ann Arbor, Michigan
Universitätsmedizin der Johannes Gutenberg Universität Mainz Mainz, Rhineland-Palatinate
Uniwersyteckie Centrum Kliniczne Gdansk,
Uppsala University Uppsala,
VCU Massey Comprehensive Cancer Center Richmond, Virginia
Vanderbilt University Medical Center Nashville, Tennessee
Virginia Cancer Specialists Fairfax, Virginia
Warringal Private Hospital Heidelberg,
Washington University School of Medicine St Louis, Missouri
West China Hospital of Sichuan University Chengdu,
Western Health Sunshine Hospital St Albans,
Winship Cancer Institute Emory University Atlanta, Georgia
Wojewodzki Szpital Specjalistyczny Biała Podlaska,
Yitzhak Shamir Medical Center Ẕerifin, Central District
Zhejiang Cancer Hospital Hangzhou, Zhejiang

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer (OrigAMI-2)

Contact(s):

Study Contact - Participate-In-This-Study1@its.jnj.com

Principal Investigator:

System ID: NCT06662786

Show full eligibility criteria

Inclusion Criteria:

* Have histologically or cytologically confirmed adenocarcinoma of the left-sided colorectal cancer. Participants must have unresectable or metastatic disease * Determined to have Kirsten rat sarcoma viral oncogene (KRAS), neuroblastoma RAS viral oncogene homolog (NRAS), and v-raf murine sarcoma viral oncogene homolog B (BRAF) wild-type (WT) tumor by local and/or central testing (if available) * Must agree to the submission of fresh tumor tissue * Have measurable disease according to RECIST v1.1 * Has not received any prior systemic therapy for unresectable or metastatic colorectal cancer (CRC). Prior adjuvant/neoadjuvant therapy in the non-metastatic disease is permitted. However, the last course of adjuvant or neoadjuvant chemotherapy must have concluded greater than (\>) 12 months prior to CRC recurrence/metastases * Have an eastern cooperative oncology group (ECOG) performance status (PS) of 0 or 1

Exclusion Criteria:

* Has medical history of (noninfectious) interstitial lung disease (ILD) /pneumonitis/pulmonary fibrosis or has current ILD/pneumonitis/pulmonary fibrosis, or where suspected ILD/pneumonitis/pulmonary fibrosis cannot be ruled out by imaging at screening * Has known allergies, hypersensitivity, or intolerance to excipients of any of the following: (a) amivantamab or cetuximab, (b) any component of mFOLFOX6 and, (c) any component of FOLFIRI * Has a prior or concurrent second malignancy other than the disease under study or one whose natural history or treatment is likely to interfere with any study endpoints of safety or the efficacy of the study treatment(s) * Participant with known mismatch repair deficiency (dMMR)/ high microsatellite instability (MSI-H) status and human epidermal growth factor receptor 2 (HER2)-positive/amplified tumor * Has prior exposure to any agents that target epidermal growth factor receptor (EGFR), mesenchymal epithelial transition (MET) or vascular endothelial growth factor (VEGF)

Interventions: BIOLOGICAL: Amivantamab, BIOLOGICAL: Cetuximab, DRUG: 5-fluorouracil, DRUG: Leucovorin calcium/Levoleucovorin, DRUG: Oxaliplatin, DRUG: Irinotecan Hydrochloride

Conditions: Colorectal Neoplasms

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Study Locations

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Location	Contacts
AZ Groeninge Kortrijk,
AZ Maria Middelares Ghent,
Adana City Hospital Adana,
Addenbrooke's Hospital Cambridge,
AdventHealth Medical Group Oncology and Hematology at Orlando Orlando, Florida
Aichi Cancer Center Nagoya,
Ankara Bilkent Sehir Hastanesi Ankara,
Antoni van Leeuwenhoek Amsterdam,
Arthur J E Child Comprehensive Cancer Centre Calgary, Alberta
Asan Medical Center Seoul,
Asklepios Klinik Altona Hamburg,
Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia Vitória,
Assuta MC Tel Aviv,
Astera Cancer Care East Brunswick, New Jersey
Azienda Ospedaliero Universitaria Pisana Pisa,
B P Poddar Hospital and Medical research Limited Kolkata,
Bakirkoy Training and Research Hospital Istanbul,
Banner MD Anderson Cancer Center Gilbert, Arizona
Baylor Scott and White Health Temple, Texas
Beijing Cancer Hospital Beijing, Beijing Municipality
Beijing Friendship Hospital Capital Medical University Beijing,
Bialostockie Centrum Onkologii im Marii Sklodowskiej Curie w Bialymstoku Bialystok,
Birmingham Heartlands Hospital Birmingham,
CBCC Global Research Bakersfield, California
CHU Nantes Nantes,
CHU de Poitiers Poitiers,
Cancer Center Of Kansas Wichita, Kansas
Cancer and Blood Specialty Clinic Los Alamitos, California
Castle Hill Hospital Hull,
Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman Liège,
Centre de Recherche du CHUM Montreal, Quebec
Charite Universitatsmedizin Berlin Campus Virchow Klinikum Berlin,
Chiba Cancer Center Chiba, Chiba
Cleveland Clinic Cancer Center Fairview Hospital Moll Pavilion Cleveland, Ohio
Cleveland Clinic Cancer Center Hillcrest Hospital Mayfield Heights, Ohio
Cleveland Clinic Cancer Center Independence Family Health Center Independence, Ohio
Cleveland Clinic Cancer Center Mansfield Mansfield, Ohio
Cleveland Clinic Cancer Center South Pointe Hospital Warrensville Heights, Ohio
Cleveland Clinic Cancer Center Strongsville Strongsville, Ohio
Cleveland Clinic Cancer Centers Sandusky Sandusky, Ohio
Clinica Univ. de Navarra Pamplona,
Clinica de Hematologia e Oncologia Viver Ltda Santa Maria,
Comprehensive Cancer Centers of Nevada Las Vegas, Nevada
Deenanath Mangeshkar Hospital and Research Centre Pune,
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital Ankara,
Elisabeth-TweeSteden Ziekenhuis Tilburg,
Erasmus MC Rotterdam, South Holland
Essen University Hospital Essen,
First Hospital of Shanxi Medical University Taiyuan,
Florida Cancer Specialists East West Palm Beach, Florida
Florida Cancer Specialists North Region St. Petersburg, Florida
Florida Cancer Specialists South Fort Myers, Florida
Fort Wayne Medical Oncology & Hematology Fort Wayne, Indiana
Fox Chase Cancer Center Philadelphia, Pennsylvania
Fred Hutchinson Cancer Research Center Seattle, Washington
Fudan University Shanghai Cancer Center Shanghai, Shanghai Municipality
Fundacao Antonio Prudente A C Camargo Cancer Center São Paulo,
Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base São José do Rio Preto,
Fundacao Pio XII Barretos, São Paulo
Fundação Doutor Amaral Carvalho Jaú,
Fundação Faculdade de Medicina - Instituto do Cancer do Estado de São Paulo São Paulo,
Fundação Universidade de Caxias do Sul Caxias do Sul,
Gabrail Cancer Center Canton, Ohio
Gazi Universitesi Hastanesi Ankara,
Georgetown Univ Medical Center Lombardi Cancer Center Washington D.C., District of Columbia
Grady Memorial Hospital Delaware, Ohio
Guangdong Provincial People's Hospital Guangzhou,
Gulhane Egitim ve Arastirma Hastanesi Ankara,
Gustave Roussy Villejuif,
Hadassah University Hospita Ein Kerem Jerusalem,
Harbin Medical University Cancer Hospital Harbin, Heilongjiang
Hattiesburg Clinic Hattiesburg, Mississippi
Henry Ford Hospital Detroit, Michigan
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York, New York
Highlands Oncology Group Springdale, Arkansas
Hopital Claude Huriez Lille,
Hopital De Jolimont Haine Saint Paul La Louviere,
Hopital Haut Leveque Pessac,
Hopital Prive Jean Mermoz Lyon,
Hopital Saint Antoine Paris,
Hosp Univ Vall D Hebron Barcelona,
Hosp. Clinico Univ. de Valencia Valencia,
Hosp. Gral. Univ. Gregorio Marañon Madrid,
Hosp. Univ. 12 de Octubre Madrid,
Hosp. Univ. Ramon Y Cajal Madrid,
Hosp. Virgen Del Rocio Seville,
Hosp. de La Santa Creu I Sant Pau Barcelona,
Hospital Canselor Tuanku Muhriz UKM Cheras, Kuala Lumpur
Hospital Kuala Lumpur Kuala Lumpur,
Hospital Nossa Senhora da Conceicao S A Porto Alegre,
Hospital Pulau Pinang George Town, Pulau Pinang
Hospital Raja Permaisuri Bainun Ipoh,
Hospital Santa Izabel Santa Casa de Misericordia da Bahia Salvador,
Hospital Umum Sarawak Kuching,
Hubei Cancer Hospital Wuhan,
Huizhou Central People's Hospital Huizhou,
Hunan Cancer Hospital Changsha, Hunan
Illinois CancerCare Bloomington, Illinois
Inova Schar Cancer Institute Dept of Fairfax Hospital Fairfax, Virginia
Institut Jules Bordet Anderlecht,
Institut Sainte Catherine Avignon,
Institut du Cancer de Montpellier Montpellier,
Instytut Centrum Zdrowia Matki Polki Lodz, Łódź Voivodeship
Istituto Clinico Humanitas Rozzano,
Istituto Dei Tumori Di Milano Milan,
Istituto Oncologico Veneto - IRCCS Padova,
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola, Emilia-Romagna
Kaohsiung Chang Gung Memorial Hospital Kaohsiung City,
Kaohsiung Medical University Chung Ho Memorial Hospital Kaohsiung City,
Karolinska Universitetssjukhuset Stockholm,
Klinikum der Universitaet Muenchen Munich,
Krankenhaus NorthWest Frankfurt am Main,
Kyungpook National University Chilgok Hospital Daegu,
Liaoning Cancer Hospital and Institute Shenyang, Liaoning
Linkou Chang Gung Memorial Hospital Taoyuan District,
Los Angeles Cancer Network Los Angeles, California
MD Anderson Cancer Center Houston, Texas
Mahamana Pandit Madan Mohan Malviya Cancer Centre Varanasi,
Markhot Ferenc Oktatokorhaz es Rendelointezet Eger,
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi Istanbul,
Meander Medisch Centrum Amersfoort,
MedStar Franklin Square Medical Center Rosedale, Maryland
Mission Cancer Blood Waukee, Iowa
Montefiore Einstein Comprehensive Cancer Center The Bronx, New York
Mount Sinai New York, New York
Mount Sinai West New York, New York
Mount Vernon Cancer Centre Northwood,
NYU Langone Medical Center NYU Hematology Associates New York, New York
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy Warsaw,
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach Gliwice,
National Cancer Center Hospital Tokyo,
National Cancer Center Hospital East Chiba, Kashiwa,
National Cancer Institute Vilnius,
National Center for Tumor Diseases NCT Heidelberg,
National Cheng Kung University Hospital Tainan,
National Hospital Organization Osaka National Hospital Osaka,
National Taiwan University Hospital Taipei,
Nebraska Cancer Specialists Midwest Cancer Center Omaha, Nebraska
Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi Konya,
New York Cancer and Blood Specialists Shirley, New York
Ochsner Clinic Foundation Jefferson, Louisiana
Oregon Health and Science University Portland, Oregon
Osaka International Cancer Institute Osaka, Osaka,
Ottawa Hospital Ottawa,
Pan American Center for Oncology Trials LLC San Juan,
Pecsi Tudomanyegyetem Pécs,
Peking University First Hospital Beijing,
Peking University Shenzhen Hospital Shenzhen, Guangdong
Peking University Third Hospital Beijing,
Perlmutter Cancer Center at NYU Long Island Mineola, New York
Praxis fur interdisziplinare Onkologie & Hamatologie GbR Freiburg im Breisgau,
Princess Margaret Cancer Centre Toronto, Ontario
Providence Medical Foundation Fullerton, California
Rabin Medical Center Petah Tikva, Central District
Radboud University Medical Center Nijmegen,
Rajiv Gandhi Cancer Institute And Research Centre Delhi,
Rambam Medical Center Haifa,
Richmond VA Medical Center Richmond, Virginia
Rocky Mountain Cancer Centers Denver, Colorado
Royal Marsden Hospital (Sutton) London,
Rutgers Cancer Institute New Brunswick, New Jersey
SCRI Oncology Partners Nashville, Tennessee
SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego Opole,
START Midwest Grand Rapids, Michigan
Sahlgrenska University Hospital Gothenburg,
Sakarya University Training and Research Hospital Sakarya,
Samsung Medical Center Gangnam-gu,
Semmelweis Egyetem Budapest,
Seoul National University Hospital Seoul,
Severance Hospital Yonsei University Health System Seoul, Seoul-teukbyeolsi [Seoul]
Sheba Medical Center Ramat Gan, Central District
Shizuoka Cancer Center Shizuoka, Suntou
Skanes universitetssjukhus Lund,
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein São Paulo,
St Bartholomew's Hospital London,
St James University Hospital Leeds,
St. Bernard's Medical Center Jonesboro, Arkansas
Sun Yat Sen University Cancer Center Guangzhou, Guangdong
Swedish Cancer Institute Seattle, Washington
Swedish Cancer Institute Edmonds Edmonds, Washington
Swedish Cancer Institute Issaquah Issaquah, Washington
Szegedi Tudomanyegyetem Szeged,
Szpital Kliniczny MSWiA z WMCO Olsztyn,
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza Brzozów,
Södersjukhuset Stockholm,
Tata Memorial Hospital Mumbai, Maharashtra
Taussig Cancer Insititute Cleveland Clinic Cleveland, Ohio
Tel Aviv Sourasky Medical Center Tel Aviv,
Texas Oncology - San Antonio San Antonio, Texas
Texas Oncology DFW Dallas, Texas
Texas Oncology West Texas Abilene, Texas
The Cancer Institute Hospital of JFCR Koto-ku, Tokyo
The Catholic University of Korea Seoul St Marys Hospital Seoul,
The First Affiliated Hospital Zhejiang University College of Medicine Hangzhou,
The First Affiliated Hospital of NanChang University Nanchang,
The First Bethune Hospital of Jilin University Changchun,
The Second Affiliated Hospital of Zhejiang University College of Medicine Hangzhou,
The Sixth Affiliated Hospital Sun Yat sen University Guangzhou,
The University of Osaka Hospital Suita, Osaka
Thomas Jefferson University Philadelphia, Pennsylvania
Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin Municipality
Torrance Memorial Physicians Network Torrance, California
UCLA Santa Monica, California
UMC Utrecht Utrecht,
USC Norris Comprehensive Cancer Center Los Angeles, California
UT Southwestern Dallas, Texas
Universitaetsklinikum Carl Gustav Carus TU Dresden Dresden,
Universitair Ziekenhuis Antwerpen Edegem,
Universitair Ziekenhuis Leuven Leuven,
University College Hospital London,
University Hospitals Cleveland Medical Center Cleveland, Ohio
University Malaya Medical Centre Lembah Pantai,
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center Pittsburgh, Pennsylvania
University of Iowa Hospital Iowa City, Iowa
University of Michigan Ann Arbor, Michigan
University of New Mexico Cancer Center Albuquerque, New Mexico
University of North Carolina at Chapel Hill Chapel Hill, North Carolina
Universitätsklinikum Ulm Ulm, Baden-Wurttemberg
Universitätsmedizin der Johannes Gutenberg Universität Mainz Mainz, Rhineland-Palatinate
Uniwersyteckie Centrum Kliniczne Gdansk,
Uppsala University Uppsala,
VA Ann Arbor Healthcare System Ann Arbor, Michigan
VCU Massey Comprehensive Cancer Center Richmond, Virginia
Virginia Cancer Specialists Fairfax, Virginia
Washington University School of Medicine St Louis, Missouri
West China Hospital of Sichuan University Chengdu,
Western General Hospital Edinburgh,
William S. Middleton Memorial VA Madison, Wisconsin
Winship Cancer Institute Emory University Atlanta, Georgia
Wojewodzki Szpital Specjalistyczny Biała Podlaska,
Wooster Milltown Specialty and Surgery Center Wooster, Ohio
Yale University School of Medicine North Haven, Connecticut
Yitzhak Shamir Medical Center Ẕerifin, Central District
Zhejiang Cancer Hospital Hangzhou, Zhejiang

Role of Circadian Factors in Inflammation and Colorectal Adenoma Risk

Contact(s):

Shetty, Shreya - shettysa@vcu.edu

Principal Investigator: Burch, James

System ID: 17947

IRB Number: HM20021857

Conditions: Rectum, Colon

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Location	Contacts
Virginia Commonwealth University Richmond, Virginia	Shetty, Shreya - (shettysa@vcu.edu)

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia (LOTUS)

Contact(s):

Ashley Mack, MS - URCC_22063@urmc.rochester.edu

Principal Investigator:

System ID: NCT06073431

Show full eligibility criteria

Interventions: PROCEDURE: Biospecimen Collection, PROCEDURE: Computed Tomography, OTHER: Electronic Health Record Review, OTHER: Medical Device Usage and Evaluation, OTHER: Physical Performance Testing, PROCEDURE: Positron Emission Tomography, OTHER: Survey Administration

Conditions: Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Advanced Pancreatic Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Unresectable Colorectal Carcinoma, Unresectable Lung Non-Small Cell Carcinoma, Unresectable Pancreatic Adenocarcinoma

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Study Locations

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Location	Contacts
AMG Crystal Lake - Oncology Crystal Lake, Illinois	Site Public Contact - (advocateresearch@advocate.com)
AMG Libertyville - Oncology Libertyville, Illinois	Site Public Contact - (advocateresearch@advocatehealth.com)
Abbott-Northwestern Hospital Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Advocate Christ Medical Center Oak Lawn, Illinois
Advocate Good Samaritan Hospital Downers Grove, Illinois	Site Public Contact - (Barbara.barhamand@advocatehealth.com)
Advocate Good Shepherd Hospital Barrington, Illinois
Advocate Illinois Masonic Medical Center Chicago, Illinois
Advocate Lutheran General Hospital Park Ridge, Illinois
Advocate Outpatient Center - Oak Lawn Oak Lawn, Illinois	Site Public Contact - (ncorp@aah.org)
Advocate Sherman Hospital Elgin, Illinois
Advocate South Suburban Hospital Hazel Crest, Illinois
AnMed Health Cancer Center Anderson, South Carolina	Site Public Contact - (rhonda.ballew@anmedhealth.org)
Armes Family Cancer Center Findlay, Ohio
Ascension All Saints Hospital Racine, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Calumet Hospital Chilton, Wisconsin	Site Public Contact - (AWRI.inquiry@ascension.org)
Ascension Columbia Saint Mary's Hospital - Milwaukee Milwaukee, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Columbia Saint Mary's Hospital Ozaukee Mequon, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Mercy Hospital Oshkosh, Wisconsin	Site Public Contact - (AWRI.inquiry@ascension.org)
Ascension Saint Elizabeth Hospital Appleton, Wisconsin	Site Public Contact - (AWRI.inquiry@ascension.org)
Ascension Saint Francis - Reiman Cancer Center Franklin, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield, Wisconsin	Site Public Contact - (AWRI.Inquiry@Ascension.org)
Aurora Bay Area Medical Group-Marinette Marinette, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora BayCare Medical Center Green Bay, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Grafton Grafton, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Kenosha South Kenosha, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Milwaukee Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Racine Racine, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Cancer Care-Southern Lakes VLCC Burlington, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Health Care Germantown Health Center Germantown, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Health Center - Greenfield Greenfield, Wisconsin	Site Public Contact - (ncorp@aah.org)
Aurora Medical Center in Summit Summit, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Saint Luke's Medical Center Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Saint Luke's South Shore Cudahy, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora Sinai Medical Center Milwaukee, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Aurora West Allis Medical Center West Allis, Wisconsin	Site Public Contact - (ncorp@aurora.org)
BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri
Beebe Health Campus Rehoboth Beach, Delaware	Site Public Contact - (research@beebehealthcare.org)
Beebe South Coastal Health Campus Millville, Delaware	Site Public Contact - (research@beebehealthcare.org)
Blanchard Valley Hospital Findlay, Ohio
Boulder Community Foothills Hospital Boulder, Colorado
Bronson Methodist Hospital Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Cancer Care Center of O'Fallon O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Cancer Center of Western Wisconsin New Richmond, Wisconsin	Site Public Contact - (mmcorc@healthpartners.com)
Carle BroMenn Medical Center Normal, Illinois	Site Public Contact - (Research@Carle.com)
Carle Cancer Center Urbana, Illinois	Site Public Contact - (Research@carle.com)
Carle Cancer Institute Normal Normal, Illinois	Site Public Contact - (Research@Carle.com)
Carle at The Riverfront Danville, Illinois	Site Public Contact - (Research@Carle.com)
Carson Tahoe Regional Medical Center Carson City, Nevada	Site Public Contact - (research@sncrf.org)
Centralia Oncology Clinic Centralia, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Christiana Care - Union Hospital Elkton, Maryland	Site Public Contact - (frank.crum@christianacare.org)
Christiana Care Health System-Christiana Hospital Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Christiana Care Health System-Wilmington Hospital Wilmington, Delaware	Site Public Contact - (lbarone@christianacare.org)
Colorado Blood Cancer Institute Denver, Colorado
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Henderson Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Northwest Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada - Town Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Condell Memorial Hospital Libertyville, Illinois	Site Public Contact - (advocateresearch@advocatehealth.com)
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Crossroads Cancer Center Effingham, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Dayton Physician LLC - Englewood Dayton, Ohio
Dayton Physicians LLC - Troy Troy, Ohio
Dayton Physicians LLC-Atrium Franklin, Ohio
Decatur Memorial Hospital Decatur, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Dickinson County Healthcare System Iron Mountain, Michigan	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Lakes Medical Center Wyoming, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Northland Medical Center Princeton, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Fairview Southdale Hospital Edina, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Geisinger Medical Center Danville, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania	Site Public Contact - (HemonCCTrials@geisinger.edu)
Gibbs Cancer Center-Gaffney Gaffney, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
Gibbs Cancer Center-Pelham Greer, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
Greater Dayton Cancer Center Kettering, Ohio
HSHS Sacred Heart Hospital Eau Claire, Wisconsin
HSHS Saint Elizabeth's Hospital O'Fallon, Illinois	Site Public Contact - (morganthaler.jodi@mhsil.com)
Hawaii Cancer Care - Westridge ‘Aiea, Hawaii	Site Public Contact - (info@hawaiicancercare.com)
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii	Site Public Contact - (i.webster@hawaiicancercare.com)
Helen F Graham Cancer Center Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Hennepin County Medical Center Minneapolis, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Highland Hospital Rochester, New York
Illinois CancerCare - Washington Washington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Bloomington Bloomington, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Canton Canton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Carthage Carthage, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Dixon Dixon, Illinois
Illinois CancerCare-Eureka Eureka, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Galesburg Galesburg, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Macomb Macomb, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Pekin Pekin, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peoria Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peru Peru, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Illinois CancerCare-Princeton Princeton, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Indu and Raj Soin Medical Center Beavercreek, Ohio
John B Amos Cancer Center Columbus, Georgia	Site Public Contact - (cdean@iacthealth.com)
Kapiolani Medical Center for Women and Children Honolulu, Hawaii
Kettering Medical Center Kettering, Ohio
Lake Regional Hospital Osage Beach, Missouri	Site Public Contact - (clinicaltrials@lakeregional.com)
Lakeview Hospital Stillwater, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Lenox Hill Hospital New York, New York
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah, Georgia	Site Public Contact - (underberga@sjchs.org)
Manhattan Eye Ear and Throat Hospital New York, New York
Marietta Memorial Hospital Marietta, Ohio	Site Public Contact - (Jeffh@columbusccop.org)
Marshfield Medical Center - Minocqua Minocqua, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Weston Weston, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Marshfield Marshfield, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin	Site Public Contact - (oncology.clinical.trials@marshfieldresearch.org)
MedStar Georgetown University Hospital Washington D.C., District of Columbia
Medical Oncology Hematology Consultants PA Newark, Delaware	Site Public Contact - (lbarone@christianacare.org)
Memorial Health University Medical Center Savannah, Georgia	Site Public Contact - (Lorraine.OHara@hcahealthcare.com)
Memorial Hospital of Carbondale Carbondale, Illinois	Site Public Contact - (clinical.research@sih.net)
Mercy Hospital Cedar Rapids, Iowa	Site Public Contact - (mmcorc@healthpartners.com)
Mercy Hospital Fort Smith Fort Smith, Arkansas
Mercy Hospital South St Louis, Missouri	Site Public Contact - (Danielle.Werle@mercy.net)
Mercy Hospital Springfield Springfield, Missouri
Methodist Medical Center of Illinois Peoria, Illinois	Site Public Contact - (andersonj@illinoiscancercare.com)
Minnesota Oncology - Burnsville Burnsville, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Missouri Baptist Medical Center St Louis, Missouri
Missouri Baptist Sullivan Hospital Sullivan, Missouri
Monticello Cancer Center Monticello, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
New Ulm Medical Center New Ulm, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
North Memorial Medical Health Center Robbinsdale, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Northeast Georgia Medical Center Braselton Braselton, Georgia	Site Public Contact - (cancerpatient.navigator@nghs.com)
Northeast Georgia Medical Center-Gainesville Gainesville, Georgia	Site Public Contact - (cancerpatient.navigator@nghs.com)
Northside Hospital Atlanta, Georgia	Site Public Contact - (ClinicalTrials@northside.com)
Northside Hospital - Duluth Duluth, Georgia	Site Public Contact - (Clinical.trials@northside.com)
Northside Hospital - Gwinnett Lawrenceville, Georgia	Site Public Contact - (Clinical.trials@northside.com)
Northwell Health/Center for Advanced Medicine Lake Success, New York
Noyes Memorial Hospital/Myers Cancer Center Dansville, New York	Site Public Contact - (WCICTOresearch@urmc.rochester.edu)
OSF Saint Anthony's Health Center Alton, Illinois
Ochsner Medical Center Jefferson New Orleans, Louisiana	Site Public Contact - (Elisemarie.curry@ochsner.org)
Oncology Hematology Care Inc-Kenwood Cincinnati, Ohio
OptumCare Cancer Care at Charleston Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
OptumCare Cancer Care at Fort Apache Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
OptumCare Cancer Care at MountainView Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
OptumCare Cancer Care at Seven Hills Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Pali Momi Medical Center ‘Aiea, Hawaii
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Parkland Health Center - Farmington Farmington, Missouri
PeaceHealth Saint John Medical Center Longview, Washington	Site Public Contact - (kmakin-bond@peacehealth.org)
PeaceHealth Saint Joseph Medical Center Bellingham, Washington
PeaceHealth Southwest Medical Center Vancouver, Washington	Site Public Contact - (kmakin-bond@peacehealth.org)
Pluta Cancer Center Rochester, New York	Site Public Contact - (ctsucontact@westat.com)
Prisma Health Cancer Institute - Butternut Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Eastside Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Faris Greenville, South Carolina	Site Public Contact - (Kim.Williams3@prismahealth.org)
Providence Newberg Medical Center Newberg, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Portland Medical Center Portland, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Saint Vincent Medical Center Portland, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Providence Willamette Falls Medical Center Oregon City, Oregon	Site Public Contact - (CanRsrchStudies@providence.org)
Queen's Cancer Cenrer - POB I Honolulu, Hawaii
Queen's Cancer Center - Kuakini Honolulu, Hawaii
Queen's Cancer Center - Pearlridge ‘Aiea, Hawaii
Queen's Medical Center Honolulu, Hawaii
Regions Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Reid Health Richmond, Indiana
Renown Regional Medical Center Reno, Nevada	Site Public Contact - (research@sncrf.org)
Rice Memorial Hospital Willmar, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Ridgeview Medical Center Waconia, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Rocky Mountain Cancer Centers - Centennial Centennial, Colorado
Rocky Mountain Cancer Centers - Swedish Englewood, Colorado
Rocky Mountain Cancer Centers-Aurora Aurora, Colorado
Rocky Mountain Cancer Centers-Boulder Boulder, Colorado
Rocky Mountain Cancer Centers-Lakewood Lakewood, Colorado
Rocky Mountain Cancer Centers-Littleton Littleton, Colorado
Rocky Mountain Cancer Centers-Midtown Denver, Colorado
Rocky Mountain Cancer Centers-Rose Denver, Colorado
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado
Rocky Mountain Cancer Centers-Thornton Thornton, Colorado
SIH Cancer Institute Carterville, Illinois	Site Public Contact - (clinical.research@sih.net)
SMC Center for Hematology Oncology Union Union, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
Saint Elizabeth Boardman Hospital Boardman, Ohio
Saint Elizabeth Youngstown Hospital Youngstown, Ohio
Saint Francis Regional Medical Center Shakopee, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Saint John's Hospital - Healtheast Maplewood, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
Saint Joseph Warren Hospital Warren, Ohio
Saint Joseph's/Candler - Bluffton Campus Bluffton, South Carolina	Site Public Contact - (underberga@sjchs.org)
Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin	Site Public Contact - (WI_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin	Site Public Contact - (wi_research_admin@hshs.org)
Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri
Shenandoah Oncology PC Winchester, Virginia	Site Public Contact - (William.Houck@usoncology.com)
South Carolina Cancer Specialists PC Hilton Head Island, South Carolina	Site Public Contact - (underberga@sjchs.org)
South Georgia Medical Center/Pearlman Cancer Center Valdosta, Georgia	Site Public Contact - (maryann.heddon@sgmc.org)
Southern Illinois University School of Medicine Springfield, Illinois
Spartanburg Medical Center Spartanburg, South Carolina	Site Public Contact - (kmertz-rivera@gibbscc.org)
Springfield Clinic Springfield, Illinois
Springfield Memorial Hospital Springfield, Illinois	Site Public Contact - (pallante.beth@mhsil.com)
Straub Clinic and Hospital Honolulu, Hawaii
Strecker Cancer Center-Belpre Belpre, Ohio	Site Public Contact - (Jeffh@columbusccop.org)
Summerlin Hospital Medical Center Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
The Longstreet Clinic - Gainesville Gainesville, Georgia
The Melanoma and Skin Cancer Institute Englewood, Colorado
The Queen's Medical Center - West Oahu ‘Ewa Beach, Hawaii	Site Public Contact - (rohta@queens.org)
The Women's Imaging Center Denver, Colorado
ThedaCare Regional Cancer Center Appleton, Wisconsin	Site Public Contact - (ResearchDept@thedacare.org)
Tift Regional Medical Center Tifton, Georgia
Trinity Health Grand Rapids Hospital Grand Rapids, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
United Hospital Saint Paul, Minnesota	Site Public Contact - (mmcorc@healthpartners.com)
University of Rochester Rochester, New York
Urology Specialists of Nevada - Green Valley Henderson, Nevada	Site Public Contact - (research@sncrf.org)
Urology Specialists of Nevada - Northwest Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
Urology Specialists of Nevada - Southwest Las Vegas, Nevada	Site Public Contact - (research@sncrf.org)
VCU Community Memorial Health Center South Hill, Virginia	Site Public Contact - (nemer.elmouallem@vcuhealth.org)
Valley Medical Center Renton, Washington	Site Public Contact - (research@valleymed.org)
Valley Radiation Oncology Peru, Illinois
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers, Wisconsin	Site Public Contact - (ncorp@aurora.org)
Wayne Hospital Greenville, Ohio
West Michigan Cancer Center Kalamazoo, Michigan	Site Public Contact - (crcwm-regulatory@crcwm.org)
Wilmot Cancer Institute Radiation Oncology at Greece Rochester, New York
Wilmot Cancer Institute at Webster Webster, New York	Site Public Contact - (WCICTOresearch@urmc.rochester.edu)

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics (COSMIC)

Contact(s):

Karen Craver - NCORP@wfusm.edu

Principal Investigator:

System ID: NCT06418204

Show full eligibility criteria

Inclusion Criteria:

* Adults aged 18 years or older with one of the following newly diagnosed cancers: breast cancer, colorectal cancer, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer (e.g. adenocarcinoma, squamous cell carcinoma, large cell carcinoma, adenosquamous cell carcinoma, and not otherwise specified). * Planned treatment with systemic chemotherapy (single or multi-agent, includes targeted therapy) and/or immune checkpoint inhibitor therapy (targeting PD-1, PD-L1 or CTLA-4). If unable to engage participant before treatment starts, enrollment is allowed up to the start of Cycle 2 treatment. * Participants must be able to comprehend English or Spanish (for survey completion). * Participants must have a working email address and be must be willing to complete surveys online. This can be completed at home, in the clinic or other location. * Completion of the confidential Self-Reported Screening Survey and receipt of a screening result - eligible for enrollment. * Participant must reside in the United States, officially determined per patient report on Self-reported Screening Survey * In the treating provider's opinion, the participant should have a life expectancy of \>=6 months. Participants in hospice are not eligible. Optional Sub-study (available at select sites only): * Must be willing to participate in both the main study and the sub-study at the Wake Forest University Comprehensive Cancer Center (WF CCC) and Virginia Commonwealth University (VCU). * Must be receiving treatment at the WF CCC and VCU. * Must be diagnosed with non-small cell lung cancer. * Must be planning to receive paclitaxel as part of their chemotherapy in conjunction with Immune Checkpoint Inhibitor (ICIs) PD-1, PD-L1 or CTLA-4.

Exclusion Criteria:

* Currently enrolled in an interventional supportive treatment trial to manage cancer symptoms. * Participants with known pregnancy. * Participant received systemic therapy treatment for prior cancer(s) including chemotherapy, immunotherapy, targeted therapy, and hormonal therapy. * Participants enrolled in hospice. Optional Substudy (available at select sites only): * Participants with chronic or ongoing steroid or immunomodulatory agents (i.e., prednisone, dexamethasone, etanercept, infliximab, etc.). The use of glucocorticoids as pre-medications for chemotherapy treatment is allowed. * Participants with a history of HIV, hepatitis B or hepatitis C.

Interventions: OTHER: Non-interventional Study

Conditions: Breast Carcinoma, Colorectal Carcinoma, Lung Non-Small Cell Carcinoma, Melanoma, Non-Hodgkin Lymphoma

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Show 467 locations

Study Locations

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Location	Contacts
AMG Crystal Lake - Oncology Crystal Lake, Illinois	- (advocateresearch@advocate.com)
AMG Libertyville - Oncology Libertyville, Illinois	- (advocateresearch@advocatehealth.com)
Abbott-Northwestern Hospital Minneapolis, Minnesota	- (mmcorc@healthpartners.com)
Adams Cancer Center Gettysburg, Pennsylvania
Advocate Christ Medical Center Oak Lawn, Illinois
Advocate Good Samaritan Hospital Downers Grove, Illinois	- (Barbara.barhamand@advocatehealth.com)
Advocate Good Shepherd Hospital Barrington, Illinois
Advocate High Tech Medical Park Palos Heights, Illinois	- (ncorp@aah.org)
Advocate Illinois Masonic Medical Center Chicago, Illinois
Advocate Lutheran General Hospital Park Ridge, Illinois
Advocate Outpatient Center - Aurora Aurora, Illinois	- (ncorp@aah.org)
Advocate Outpatient Center - Oak Lawn Oak Lawn, Illinois	- (ncorp@aah.org)
Advocate Sherman Hospital Elgin, Illinois
Advocate South Suburban Hospital Hazel Crest, Illinois
AnMed Health Cancer Center Anderson, South Carolina	- (rhonda.ballew@anmedhealth.org)
Annie Penn Memorial Hospital Reidsville, North Carolina	- (stacey.phelps@conehealth.com)
Armes Family Cancer Center Findlay, Ohio	- (clinical.trials@daytonncorp.org)
Ascension All Saints Hospital Racine, Wisconsin	- (AWRI.Inquiry@Ascension.org)
Ascension Calumet Hospital Chilton, Wisconsin	- (AWRI.inquiry@ascension.org)
Ascension Columbia Saint Mary's Hospital - Milwaukee Milwaukee, Wisconsin	- (AWRI.Inquiry@Ascension.org)
Ascension Columbia Saint Mary's Hospital Ozaukee Mequon, Wisconsin	- (AWRI.Inquiry@Ascension.org)
Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa, Wisconsin	- (AWRI.Inquiry@Ascension.org)
Ascension Mercy Hospital Oshkosh, Wisconsin	- (AWRI.inquiry@ascension.org)
Ascension Saint Elizabeth Hospital Appleton, Wisconsin	- (AWRI.inquiry@ascension.org)
Ascension Saint Francis - Reiman Cancer Center Franklin, Wisconsin	- (AWRI.Inquiry@Ascension.org)
Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield, Wisconsin	- (AWRI.Inquiry@Ascension.org)
Aspirus Cancer Care - James Beck Cancer Center Rhinelander, Wisconsin	- (Beth.Knetter@aspirus.org)
Aspirus Cancer Care - Stevens Point Stevens Point, Wisconsin	- (Beth.Knetter@aspirus.org)
Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids, Wisconsin
Aspirus Langlade Hospital Antigo, Wisconsin	- (Juli.Alford@aspirus.org)
Aspirus Medford Hospital Medford, Wisconsin	- (Beth.Knetter@aspirus.org)
Aspirus Regional Cancer Center Wausau, Wisconsin
Atrium Health Cabarrus/LCI-Concord Concord, North Carolina
Atrium Health Cleveland/LCI-Cleveland Shelby, North Carolina
Atrium Health Navicent Macon, Georgia	- (andrew.weatherall@atriumhealth.org)
Atrium Health Pineville/LCI-Pineville Charlotte, North Carolina
Atrium Health Stanly/LCI-Albemarle Albemarle, North Carolina
Atrium Health Union/LCI-Union Monroe, North Carolina
Atrium Health University City/LCI-University Charlotte, North Carolina
Augusta Health Center for Cancer and Blood Disorders Fishersville, Virginia
Aurora Bay Area Medical Group-Marinette Marinette, Wisconsin	- (ncorp@aurora.org)
Aurora BayCare Medical Center Green Bay, Wisconsin	- (ncorp@aurora.org)
Aurora Cancer Care-Grafton Grafton, Wisconsin	- (ncorp@aurora.org)
Aurora Cancer Care-Kenosha South Kenosha, Wisconsin	- (ncorp@aurora.org)
Aurora Cancer Care-Milwaukee Milwaukee, Wisconsin	- (ncorp@aurora.org)
Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin	- (ncorp@aurora.org)
Aurora Cancer Care-Racine Racine, Wisconsin	- (ncorp@aurora.org)
Aurora Cancer Care-Southern Lakes VLCC Burlington, Wisconsin	- (ncorp@aurora.org)
Aurora Health Care Germantown Health Center Germantown, Wisconsin	- (ncorp@aurora.org)
Aurora Medical Center in Summit Summit, Wisconsin	- (ncorp@aurora.org)
Aurora Saint Luke's Medical Center Milwaukee, Wisconsin	- (ncorp@aurora.org)
Aurora Saint Luke's South Shore Cudahy, Wisconsin	- (ncorp@aurora.org)
Aurora Sinai Medical Center Milwaukee, Wisconsin	- (ncorp@aurora.org)
Aurora West Allis Medical Center West Allis, Wisconsin	- (ncorp@aurora.org)
BJC Outpatient Center at Sunset Hills Sunset Hills, Missouri
Baptist Cancer Center-Grenada Grenada, Mississippi	- (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee	- (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven, Mississippi	- (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus, Mississippi	- (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee	- (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Oxford Oxford, Mississippi	- (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital and Cancer Center-Union County New Albany, Mississippi	- (BCCclintrials@bmhcc.org)
Baptist Memorial Hospital for Women Memphis, Tennessee	- (BCCclintrials@bmhcc.org)
Beaufort Memorial Hospital Beaufort, South Carolina	- (kwade@bmhsc.org)
Beebe Health Campus Rehoboth Beach, Delaware	- (research@beebehealthcare.org)
Beebe South Coastal Health Campus Millville, Delaware	- (research@beebehealthcare.org)
Benefis Sletten Cancer Institute Great Falls, Montana	- (mccinfo@mtcancer.org)
Billings Clinic Cancer Center Billings, Montana	- (research@billingsclinic.org)
Blanchard Valley Hospital Findlay, Ohio	- (clinical.trials@daytonncorp.org)
Bozeman Health Deaconess Hospital Bozeman, Montana	- (mccinfo@mtcancer.org)
Broadlawns Medical Center Des Moines, Iowa
Bronson Battle Creek Battle Creek, Michigan	- (crcwm-regulatory@crcwm.org)
CHI Health Good Samaritan Kearney, Nebraska	- (ResearchInstituteInquiries@CommonSpirit.org)
Cancer Care Center of O'Fallon O'Fallon, Illinois	- (morganthaler.jodi@mhsil.com)
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois	- (morganthaler.jodi@mhsil.com)
Cancer Center at Saint Joseph's Phoenix, Arizona	- (ResearchInstituteInquiries@CommonSpirit.org)
Cancer Hematology Centers - Flint Flint, Michigan	- (wstrong@ghci.org)
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan
Carilion Roanoke Memorial Hospital Roanoke, Virginia
Carle Cancer Center Urbana, Illinois	- (Research@carle.com)
Carle Cancer Institute Normal Normal, Illinois	- (Research@Carle.com)
Carle Physician Group-Effingham Effingham, Illinois	- (Research@carle.com)
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois	- (Research@carle.com)
Carle at The Riverfront Danville, Illinois	- (Research@Carle.com)
CaroMont Health - Lincoln Cancer Center Lincolnton, North Carolina
CaroMont Regional Medical Center Gastonia, North Carolina	- (tammy.cozad@caromonthealth.org)
Carolinas Medical Center/Levine Cancer Institute Charlotte, North Carolina
Centra Alan B Pearson Regional Cancer Center Lynchburg, Virginia	- (Kevin.Patel@centrahealth.com)
CentraState Medical Center Freehold, New Jersey
Central Vermont Medical Center Berlin Corners, Vermont
Centralia Oncology Clinic Centralia, Illinois	- (morganthaler.jodi@mhsil.com)
Centro Comprensivo de Cancer de UPR San Juan,	- (dcuadrado@cccupr.org)
Chilton Medical Center Pompton, New Jersey
Christiana Care - Union Hospital Elkton, Maryland	- (frank.crum@christianacare.org)
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud, Minnesota	- (coborncancercenter@centracare.com)
Colorado Blood Cancer Institute Denver, Colorado	- (info@westernstatesncorp.org)
Community Hospital of Anaconda Anaconda, Montana	- (mccinfo@mtcancer.org)
Community Medical Center Missoula, Montana	- (mccinfo@mtcancer.org)
Community Medical Center Missoula, Montana	- (HemonCCTrials@geisinger.edu)
Condell Memorial Hospital Libertyville, Illinois	- (advocateresearch@advocatehealth.com)
Cone Health Cancer Center Greensboro, North Carolina	- (stacey.phelps@conehealth.com)
Cone Health Cancer Center at Alamance Regional Burlington, North Carolina	- (stacey.phelps@conehealth.com)
Cone Health Cancer Center at Drawbridge Parkway Greensboro, North Carolina	- (stacey.phelps@conehealth.com)
Cone Health MedCenter Asheboro Asheboro, North Carolina	- (stacey.phelps@conehealth.com)
Contra Costa Regional Medical Center Martinez, California
Contra Costa Regional Medical Center Martinez, California
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan	- (crcwm-regulatory@crcwm.org)
Corewell Health Reed City Hospital Reed City, Michigan	- (crcwm-regulatory@crcwm.org)
Cotton O'Neil Cancer Center / Stormont Vail Health Topeka, Kansas
Cox Health South Hospital Springfield, Missouri
CoxHealth South Hospital Springfield, Missouri
Crossroads Cancer Center Effingham, Illinois	- (morganthaler.jodi@mhsil.com)
Dayton Physician LLC - Englewood Dayton, Ohio	- (clinical.trials@daytonncorp.org)
Dayton Physicians LLC-Atrium Franklin, Ohio	- (clinical.trials@daytonncorp.org)
Decatur Memorial Hospital Decatur, Illinois	- (morganthaler.jodi@mhsil.com)
Doctors Cancer Center Manati,
Duluth Clinic Ashland Ashland, Wisconsin	- (CancerTrials@EssentiaHealth.org)
Edwards Comprehensive Cancer Center Huntington, West Virginia	- (Christina.Cole@chhi.org)
Englewood Hospital and Medical Center Englewood, New Jersey
Ephrata Cancer Center Ephrata, Pennsylvania
Essentia Health - Deer River Clinic Deer River, Minnesota	- (CancerTrials@EssentiaHealth.org)
Essentia Health - Fosston Fosston, Minnesota	- (CancerTrials@EssentiaHealth.org)
Essentia Health - Park Rapids Park Rapids, Minnesota	- (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center Duluth, Minnesota	- (CancerTrials@EssentiaHealth.org)
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota	- (CancerTrials@EssentiaHealth.org)
Essentia Health Hibbing Clinic Hibbing, Minnesota
Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota	- (CancerTrials@EssentiaHealth.org)
Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes, Minnesota	- (CancerTrials@EssentiaHealth.org)
Essentia Health Sandstone Sandstone, Minnesota	- (CancerTrials@EssentiaHealth.org)
Essentia Health Virginia Clinic Virginia, Minnesota	- (CancerTrials@EssentiaHealth.org)
Essentia Health-Hayward Clinic Hayward, Wisconsin	- (CancerTrials@EssentiaHealth.org)
Essentia Health-Spooner Clinic Spooner, Wisconsin	- (CancerTrials@EssentiaHealth.org)
Fairbanks Memorial Hospital Fairbanks, Alaska	- (Veronica.Stevenson@foundationhealth.org)
Fairview Northland Medical Center Princeton, Minnesota	- (mmcorc@healthpartners.com)
Fairview Southdale Hospital Edina, Minnesota	- (mmcorc@healthpartners.com)
Flaget Memorial Hospital Bardstown, Kentucky	- (ResearchInstituteInquiries@CommonSpirit.org)
Geisinger Cancer Center Dickson City Dickson City, Pennsylvania	- (hemoncctrials@geisinger.edu)
Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania	- (HemonCCTrials@geisinger.edu)
Geisinger Medical Center Danville, Pennsylvania	- (HemonCCTrials@geisinger.edu)
Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania	- (HemonCCTrials@geisinger.edu)
Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania	- (HemonCCTrials@geisinger.edu)
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania	- (HemonCCTrials@geisinger.edu)
Genesee Hematology Oncology PC Flint, Michigan	- (wstrong@ghci.org)
Gibbs Cancer Center-Gaffney Gaffney, South Carolina	- (kmertz-rivera@gibbscc.org)
Gibbs Cancer Center-Pelham Greer, South Carolina	- (kmertz-rivera@gibbscc.org)
Glens Falls Hospital Glens Falls, New York	Misty J DeCaro - (lacrosmj@glensfallshosp.org)
Greater Dayton Cancer Center Kettering, Ohio	- (clinical.trials@daytonncorp.org)
Gundersen Lutheran Medical Center La Crosse, Wisconsin	- (cancerctr@gundersenhealth.org)
HSHS Saint Elizabeth's Hospital O'Fallon, Illinois	- (morganthaler.jodi@mhsil.com)
Hackettstown Medical Center Hackettstown, New Jersey
Harold Alfond Center for Cancer Care Augusta, Maine
Hawaii Cancer Care - Westridge ‘Aiea, Hawaii	- (info@hawaiicancercare.com)
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu, Hawaii	- (i.webster@hawaiicancercare.com)
HaysMed Hays, Kansas
Hayworth Cancer Center High Point, North Carolina
Heartland Regional Medical Center Saint Joseph, Missouri	- (Trisha.England2@mymlc.com)
Helen F Graham Cancer Center Newark, Delaware	- (lbarone@christianacare.org)
Hematology Oncology Associates of Fredericksburg Inc Fredericksburg, Virginia	- (cvaughn@hoafredericksburg.com)
Hennepin County Medical Center Minneapolis, Minnesota	- (mmcorc@healthpartners.com)
Hi-Line Sletten Cancer Center Havre, Montana	- (mccinfo@mtcancer.org)
Holy Name Hospital Teaneck, New Jersey
Illinois CancerCare - Washington Washington, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Bloomington Bloomington, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Canton Canton, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Carthage Carthage, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Dixon Dixon, Illinois
Illinois CancerCare-Eureka Eureka, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Galesburg Galesburg, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Macomb Macomb, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Pekin Pekin, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peoria Peoria, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Peru Peru, Illinois	- (andersonj@illinoiscancercare.com)
Illinois CancerCare-Princeton Princeton, Illinois	- (andersonj@illinoiscancercare.com)
Indu and Raj Soin Medical Center Beavercreek, Ohio	- (clinical.trials@daytonncorp.org)
Iowa Methodist Medical Center Des Moines, Iowa
Jefferson Healthcare Port Townsend, Washington
John H Stroger Jr Hospital of Cook County Chicago, Illinois
Kadlec Clinic Hematology and Oncology Kennewick, Washington	- (research@kadlecmed.org)
Kaiser Permanente Bellevue Medical Center Bellevue, Washington	- (KPWAoncologytrials@kp.org)
Kaiser Permanente Downtown Commons Sacramento, California	- (kpoct@kp.org)
Kaiser Permanente Dublin Dublin, California
Kaiser Permanente Fresno Orchard Plaza Fresno, California
Kaiser Permanente Medical Center - Santa Clara Santa Clara, California	- (Kpoct@kp.org)
Kaiser Permanente Medical Center-Vacaville Vacaville, California	- (Kpoct@kp.org)
Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii	- (shelley.a.clark@kp.org)
Kaiser Permanente Northwest Portland, Oregon	- (information@kpchr.org)
Kaiser Permanente San Leandro San Leandro, California	- (Kpoct@kp.org)
Kaiser Permanente Washington Seattle, Washington	- (KPWAoncologytrials@kp.org)
Kaiser Permanente- Marshall Medical Offices Redwood City, California
Kaiser Permanente- Modesto MOB II Modesto, California
Kaiser Permanente-Deer Valley Medical Center Antioch, California	- (Kpoct@kp.org)
Kaiser Permanente-Franklin Denver, Colorado	- (kristi.m.bronkan@kp.org)
Kaiser Permanente-Fremont Fremont, California	- (Kpoct@kp.org)
Kaiser Permanente-Fresno Fresno, California	- (Kpoct@kp.org)
Kaiser Permanente-Lone Tree Lone Tree, Colorado	- (kristi.m.bronkan@kp.org)
Kaiser Permanente-Modesto Modesto, California	- (Kpoct@kp.org)
Kaiser Permanente-Oakland Oakland, California	- (Kpoct@kp.org)
Kaiser Permanente-Richmond Richmond, California	- (Kpoct@kp.org)
Kaiser Permanente-Rock Creek Lafayette, Colorado	- (kristi.m.bronkan@kp.org)
Kaiser Permanente-Roseville Roseville, California	- (Kpoct@kp.org)
Kaiser Permanente-San Francisco San Francisco, California	- (Kpoct@kp.org)
Kaiser Permanente-Santa Rosa Santa Rosa, California	- (Kpoct@kp.org)
Kaiser Permanente-Santa Teresa-San Jose San Jose, California	- (Kpoct@kp.org)
Kaiser Permanente-South Sacramento Sacramento, California	- (Kpoct@kp.org)
Kaiser Permanente-South San Francisco South San Francisco, California	- (Kpoct@kp.org)
Kaiser Permanente-Stockton Stockton, California	- (Kpoct@kp.org)
Kaiser Permanente-Vallejo Vallejo, California	- (Kpoct@kp.org)
Kaiser Permanente-Walnut Creek Walnut Creek, California	- (Kpoct@kp.org)
Kaiser San Rafael-Gallinas San Rafael, California	- (Kpoct@kp.org)
Kapiolani Medical Center for Women and Children Honolulu, Hawaii
Kettering Medical Center Kettering, Ohio	- (clinical.trials@daytonncorp.org)
Kettering Medical Center Kettering, Ohio	- (clinical.trials@daytonncorp.org)
Kingman Regional Medical Center Kingman, Arizona	- (research@sncrf.org)
Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho	- (mccinfo@mtcancer.org)
Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho	- (mccinfo@mtcancer.org)
Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho	- (mccinfo@mtcancer.org)
LSU Health Sciences Center at Shreveport Shreveport, Louisiana	- (LPost@lsuhsc.edu)
Lake Regional Hospital Osage Beach, Missouri	- (clinicaltrials@lakeregional.com)
Lakeview Hospital Stillwater, Minnesota	- (mmcorc@healthpartners.com)
Lawrence Memorial Hospital Lawrence, Kansas	- (Stephanie.Norris@LMH.ORG)
Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania	- (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania	- (Morgan_M.Horton@lvhn.org)
Lehigh Valley Hospital-Hazleton Hazleton, Pennsylvania	- (Morgan_M.Horton@lvhn.org)
Levine Cancer Institute - Huntersville Huntersville, North Carolina
Levine Cancer Institute - Rutherford Forest City, North Carolina
Levine Cancer Institute - Union West Matthews, North Carolina
Levine Cancer Institute-Ballantyne Charlotte, North Carolina
Levine Cancer Institute-Gaston Gastonia, North Carolina
Levine Cancer Institute-Rock Hill Rock Hill, South Carolina
Levine Cancer Institute-SouthPark Charlotte, North Carolina
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah, Georgia	- (underberga@sjchs.org)
Liberty County Cancer Care Hinesville, Georgia	- (Oncologyresearch@sjchs.org)
Licking Memorial Hospital Newark, Ohio	- (Jeffh@columbusccop.org)
Logan Health Medical Center Kalispell, Montana	- (mccinfo@mtcancer.org)
Lovelace Medical Center-Saint Joseph Square Albuquerque, New Mexico	- (ZPollock@salud.unm.edu)
Lovelace Women's Hospital Albuquerque, New Mexico	- (AYost@nmcca.org)
MaineHealth Cancer Care Center of York County Sanford, Maine
MaineHealth Cancer Care and IV Therapy - Brunswick Brunswick, Maine	- (clinicalresearch@mainehealth.org)
MaineHealth Cancer Care and IV Therapy - Sanford Sanford, Maine	- (clinicalresearch@mainehealth.org)
MaineHealth Cancer Care and IV Therapy - South Portland South Portland, Maine	- (clinicalresearch@mainehealth.org)
MaineHealth Maine Medical Center - Biddeford Biddeford, Maine	- (clinicalresearch@mainehealth.org)
MaineHealth Maine Medical Center- Scarborough Scarborough, Maine	- (clinicalresearch@mainehealth.org)
MaineHealth Penobscot Bay Hospital Rockport, Maine	- (clinicalresearch@mainehealth.org)
MaineHealth Waldo Hospital Belfast, Maine	- (clinicalresearch@mainehealth.org)
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Clinic-Chippewa Center Chippewa Falls, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Clinic-Wausau Center Wausau, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Ladysmith Ladysmith, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Minocqua Minocqua, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Neillsville Neillsville, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center - Weston Weston, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center Dickinson Iron Mountain, Michigan	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Marshfield Marshfield, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin	- (oncology.clinical.trials@marshfieldresearch.org)
Mayo Clinic Rochester, Minnesota
Mayo Clinic Health System in Albert Lea Albert Lea, Minnesota
Mayo Clinic Health System-Eau Claire Clinic Eau Claire, Wisconsin
Mayo Clinic Health System-Franciscan Healthcare La Crosse, Wisconsin
Mayo Clinic Health Systems-Mankato Mankato, Minnesota
Medical Oncology Hematology Consultants PA Newark, Delaware	- (lbarone@christianacare.org)
Medical University of South Carolina Charleston, South Carolina	- (hcc-clinical-trials@musc.edu)
Memorial Hospital Marysville, Ohio	- (Jeffh@columbusccop.org)
Memorial Medical Center-Las Cruces Las Cruces, New Mexico	- (Deborah.Brown@LPNT.net)
Mercy Cancer Center - Carmichael Carmichael, California	- (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Elk Grove Elk Grove, California	- (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Rocklin Rocklin, California	- (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center - Sacramento Sacramento, California	- (ResearchInstituteInquiries@CommonSpirit.org)
Mercy Cancer Center-West Lakes Clive, Iowa	- (cancerresearch@mercydesmoines.org)
Mercy Health - Paducah Cancer Center Paducah, Kentucky	- (BJWarner@mercy.com)
Mercy Hospital Cedar Rapids, Iowa	- (mmcorc@healthpartners.com)
Mercy Hospital Fort Smith Fort Smith, Arkansas
Mercy Hospital Joplin Joplin, Missouri	- (esmeralda.carrillo@mercy.net)
Mercy Hospital Oklahoma City Oklahoma City, Oklahoma
Mercy Hospital Saint Louis St Louis, Missouri
Mercy Hospital South St Louis, Missouri	- (Danielle.Werle@mercy.net)
Mercy Hospital Springfield Springfield, Missouri
Mercy Medical Center - Des Moines Des Moines, Iowa	- (cancerresearch@mercydesmoines.org)
Mercy Oncology and Hematology - Clayton-Clarkson Ballwin, Missouri
Mercy San Juan Medical Center Carmichael, California	- (OncologyResearch@DignityHealth.org)
Mid Coast Hospital Brunswick, Maine	- (elizabeth.mutina@mainehealth.org)
Minnesota Oncology - Burnsville Burnsville, Minnesota	- (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota	- (mmcorc@healthpartners.com)
Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota	- (mmcorc@healthpartners.com)
Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande, California	- (ResearchInstituteInquiries@CommonSpirit.org)
Mission Hope Medical Oncology - Santa Maria Santa Maria, California	- (ResearchInstituteInquiries@CommonSpirit.org)
Missouri Baptist Medical Center St Louis, Missouri
Missouri Baptist Sullivan Hospital Sullivan, Missouri
Missouri Baptist Sullivan Hospital Sullivan, Missouri
Montana Cancer Consortium NCORP Billings, Montana	- (mccinfo@mtcancer.org)
Montefiore Medical Center - Moses Campus The Bronx, New York	- (eskwak@montefiore.org)
Montefiore Medical Center-Einstein Campus The Bronx, New York	- (eskwak@montefiore.org)
Monticello Cancer Center Monticello, Minnesota	- (mmcorc@healthpartners.com)
Monument Health Rapid City Hospital Rapid City, South Dakota	- (research@monument.health)
Morristown Medical Center Morristown, New Jersey
Morton Plant Hospital Clearwater, Florida
Munson Medical Center Traverse City, Michigan	- (crcwm-regulatory@crcwm.org)
MyMichigan Medical Center Alpena Alpena, Michigan	- (CVResearch@mymichigan.org)
MyMichigan Medical Center Gladwin Gladwin, Michigan	- (CVResearch@mymichigan.org)
MyMichigan Medical Center Gratiot Alma, Michigan	- (CVResearch@mymichigan.org)
MyMichigan Medical Center Midland Midland, Michigan	- (CVResearch@mymichigan.org)
MyMichigan Medical Center Mount Pleasant Mount Pleasant, Michigan	- (CVResearch@mymichigan.org)
MyMichigan Medical Center Saginaw Saginaw, Michigan	- (MCRCwebsitecontactform@stjoeshealth.org)
MyMichigan Medical Center Tawas Tawas City, Michigan	- (MCRCwebsitecontactform@stjoeshealth.org)
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro, Arkansas
New Ulm Medical Center New Ulm, Minnesota	- (mmcorc@healthpartners.com)
Newton Medical Center Newton, New Jersey
North Memorial Medical Health Center Robbinsdale, Minnesota	- (mmcorc@healthpartners.com)
Northside Hospital Atlanta, Georgia	- (ClinicalTrials@northside.com)
Northside Hospital - Duluth Duluth, Georgia	- (Clinical.trials@northside.com)
Northside Hospital - Gwinnett Lawrenceville, Georgia	- (Clinical.trials@northside.com)
OSF Saint Anthony Medical Center Rockford, Illinois
OSF Saint Anthony's Health Center Alton, Illinois
OSF Saint Francis Hospital and Medical Group Escanaba, Michigan	- (ewd_research_admin@hshs.org)
Ochsner LSU Health Monroe Medical Center Monroe, Louisiana	- (LPost@lsuhsc.edu)
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa
OptumCare Cancer Care at Charleston Las Vegas, Nevada	- (research@sncrf.org)
OptumCare Cancer Care at Seven Hills Henderson, Nevada	- (research@sncrf.org)
Overlook Medical Center Summit, New Jersey
PCR Oncology Arroyo Grande, California	- (research@sncrf.org)
PROncology San Juan,
Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo, California	- (ResearchInstituteInquiries@CommonSpirit.org)
Pali Momi Medical Center ‘Aiea, Hawaii
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota	- (mmcorc@healthpartners.com)
Parkland Health Center - Farmington Farmington, Missouri
Penrose-Saint Francis Healthcare Colorado Springs, Colorado	- (ResearchInstituteInquiries@CommonSpirit.org)
Physicians' Clinic of Iowa PC Cedar Rapids, Iowa
Pocono Medical Center East Stroudsburg, Pennsylvania	- (Morgan_M.Horton@lvhn.org)
Presbyterian Kaseman Hospital Albuquerque, New Mexico	- (WBurman@phs.org)
Presbyterian Rust Medical Center/Jorgensen Cancer Center Rio Rancho, New Mexico
Prisma Health Cancer Institute - Butternut Greenville, South Carolina
Prisma Health Cancer Institute - Easley Easley, South Carolina	- (Kim.Williams3@prismahealth.org)
Prisma Health Cancer Institute - Eastside Greenville, South Carolina
Prisma Health Cancer Institute - Faris Greenville, South Carolina
Prisma Health Cancer Institute - Greer Greer, South Carolina
Prisma Health Cancer Institute - Seneca Seneca, South Carolina
Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina
Providence Medical Foundation - Santa Rosa Santa Rosa, California
Providence Saint Mary Regional Cancer Center Walla Walla, Washington	- (Cheryl.Dodd@providence.org)
Queen's Cancer Center - Kuakini Honolulu, Hawaii
Queen's Cancer Center - POB I Honolulu, Hawaii
Queen's Medical Center Honolulu, Hawaii
Queens Hospital Center Jamaica, New York	Linda Bulone - (buloneL@nychhc.org)
Regional Cancer Care - Jesup Jesup, Georgia	- (Oncologyresearch@sjchs.org)
Regions Hospital Saint Paul, Minnesota	- (mmcorc@healthpartners.com)
Reid Health Richmond, Indiana	- (clinical.trials@daytonncorp.org)
Rice Memorial Hospital Willmar, Minnesota	- (mmcorc@healthpartners.com)
Ridgeview Medical Center Waconia, Minnesota	- (mmcorc@healthpartners.com)
Rocky Mountain Cancer Centers - Centennial Centennial, Colorado	- (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Aurora Aurora, Colorado	- (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Boulder Boulder, Colorado	- (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Littleton Littleton, Colorado	- (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Midtown Denver, Colorado	- (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Rose Denver, Colorado	- (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado	- (info@westernstatesncorp.org)
Rocky Mountain Cancer Centers-Thornton Thornton, Colorado	- (info@westernstatesncorp.org)
Rush-Copley Healthcare Center Yorkville, Illinois	- (Cancer.Research@rushcopley.com)
Rush-Copley Medical Center Aurora, Illinois	- (Cancer.Research@rushcopley.com)
SIH Cancer Institute Carterville, Illinois	- (clinical.research@sih.net)
SMC Center for Hematology Oncology Union Union, South Carolina	- (kmertz-rivera@gibbscc.org)
SSM Health Good Samaritan Mount Vernon, Illinois	- (gayla.hall@ssmhealth.com)
Saint Agnes Medical Center Fresno, California	- (medresearch@samc.com)
Saint Alphonsus Cancer Care Center-Baker City Baker City, Oregon	- (mccinfo@mtcancer.org)
Saint Alphonsus Cancer Care Center-Boise Boise, Idaho	- (stephanie.couch@stjoeshealth.org)
Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho	- (stephanie.couch@stjoeshealth.org)
Saint Alphonsus Cancer Care Center-Nampa Nampa, Idaho	- (mccinfo@mtcancer.org)
Saint Alphonsus Cancer Care Center-Ontario Ontario, Oregon	- (mccinfo@mtcancer.org)
Saint Anthony North Hospital Westminster, Colorado	- (ResearchInstituteInquiries@CommonSpirit.org)
Saint Anthony's Hospital Cancer Care Center St. Petersburg, Florida	- (Research.CTO@baycare.org)
Saint Elizabeth Youngstown Hospital Youngstown, Ohio	- (clinical.trials@daytonncorp.org)
Saint Francis Cancer Center Greenville, South Carolina	- (ResearchInstituteInquiries@CommonSpirit.org)
Saint Francis Cancer Center Greenville, South Carolina	- (melissa_beckman@bshsi.org)
Saint Francis Hospital Greenville, South Carolina	- (melissa_beckman@bshsi.org)
Saint Francis Regional Medical Center Shakopee, Minnesota	- (mmcorc@healthpartners.com)
Saint Helena Hospital St. Helena, California	- (Kpoct@kp.org)
Saint Helena Hospital St. Helena, California
Saint John's Hospital - Healtheast Maplewood, Minnesota	- (mmcorc@healthpartners.com)
Saint Joseph Hospital East Lexington, Kentucky	- (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph London London, Kentucky	- (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph Mount Sterling Mount Sterling, Kentucky	- (ResearchInstituteInquiries@CommonSpirit.org)
Saint Joseph's Hospital/Children's Hospital-Tampa Tampa, Florida	- (jennifer.manns@baycare.org)
Saint Joseph's Medical Center Stockton, California
Saint Joseph's/Candler - Bluffton Campus Bluffton, South Carolina	- (underberga@sjchs.org)
Saint Louis Cancer and Breast Institute-Ballwin Ballwin, Missouri
Saint Luke's Hospital of Duluth Duluth, Minnesota	- (kdean@slhduluth.com)
Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin	- (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls, Wisconsin	- (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin	- (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan, Wisconsin	- (ewd_research_admin@hshs.org)
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin	- (ewd_research_admin@hshs.org)
Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri
Salina Regional Health Center Salina, Kansas	- (mleepers@srhc.com)
Sechler Family Cancer Center Lebanon, Pennsylvania	- (doxenberg@wellspan.org)
Sheboygan Physicians Group Sheboygan, Wisconsin	- (ewd_research_admin@hshs.org)
Shenandoah Oncology PC Winchester, Virginia	- (William.Houck@usoncology.com)
Sinai Hospital of Baltimore Baltimore, Maryland	- (pridgely@lifebridgehealth.org)
South Carolina Cancer Specialists PC Hilton Head Island, South Carolina	- (underberga@sjchs.org)
South Florida Baptist Hospital Plant City, Florida	- (Claudia.Quinones@baycare.org)
Southern Illinois University School of Medicine Springfield, Illinois
Spartanburg Medical Center Spartanburg, South Carolina	- (kmertz-rivera@gibbscc.org)
Springfield Clinic Springfield, Illinois
Springfield Memorial Hospital Springfield, Illinois	- (pallante.beth@mhsil.com)
Straub Benioff Medical Center Honolulu, Hawaii
Straub Pearlridge Clinic ‘Aiea, Hawaii
Strecker Cancer Center-Belpre Belpre, Ohio	- (Jeffh@columbusccop.org)
Swedish Cancer Institute-Edmonds Edmonds, Washington	- (PCRC-NCORP@Swedish.org)
Swedish Cancer Institute-Issaquah Issaquah, Washington	- (PCRC-NCORP@Swedish.org)
Swedish Medical Center-First Hill Seattle, Washington	- (PCRC-NCORP@Swedish.org)
The Queen's Medical Center - West Oahu ‘Ewa Beach, Hawaii	- (rohta@queens.org)
The Radiation Oncology Center-Hilton Head/Bluffton Hilton Head Island, South Carolina	- (underberga@sjchs.org)
The University of Kansas Cancer Center - Olathe Olathe, Kansas	- (OlatheCCResearch@kumc.edu)
ThedaCare Cancer Care - Berlin Berlin, Wisconsin	- (ResearchDept@thedacare.org)
ThedaCare Cancer Care - New London New London, Wisconsin	- (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Oshkosh Oshkosh, Wisconsin	- (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Shawano Shawano, Wisconsin	- (ResearchDept@thedacare.org)
ThedaCare Cancer Care - Waupaca Waupaca, Wisconsin	- (ResearchDept@thedacare.org)
ThedaCare Regional Cancer Center Appleton, Wisconsin	- (ResearchDept@thedacare.org)
ThedaCare Regional Medical Center - Neenah Neenah, Wisconsin	- (ResearchDept@thedacare.org)
Tidelands Georgetown Memorial Hospital Georgetown, South Carolina	- (broe@tidelandshealth.org)
Trinity Health Grand Rapids Hospital Grand Rapids, Michigan	- (crcwm-regulatory@crcwm.org)
Trinity Health Muskegon Hospital Muskegon, Michigan	- (crcwm-regulatory@crcwm.org)
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan	- (MCRCwebsitecontactform@stjoeshealth.org)
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan	- (MCRCwebsitecontactform@stjoeshealth.org)
Tripler Army Medical Center Honolulu, Hawaii
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa
UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie, Maryland
UM Saint Joseph Medical Center Towson, Maryland	- (Jeanmarie.downing@umm.edu)
United Hospital Saint Paul, Minnesota	- (mmcorc@healthpartners.com)
University Health Truman Medical Center Kansas City, Missouri
University of Iowa Healthcare Cancer Services Quad Cities Bettendorf, Iowa	- (katherine-daprile@uiowa.edu)
University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa
University of Kansas Cancer Center - Briarcliff Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit Lee's Summit, Missouri	- (KUCC_Navigation@kumc.edu)
University of Kansas Cancer Center - North Kansas City, Missouri	- (KUCC_Navigation@kumc.edu)
University of Kansas Cancer Center-Overland Park Overland Park, Kansas	- (KUCC_Navigation@kumc.edu)
University of Kansas Health System Saint Francis Campus Topeka, Kansas
University of Kansas Hospital-Indian Creek Campus Overland Park, Kansas	- (KUCC_Navigation@kumc.edu)
University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas	- (KUCC_Navigation@kumc.edu)
University of Maryland/Greenebaum Cancer Center Baltimore, Maryland
University of Michigan Health - West Wyoming, Michigan	- (crcwm-regulatory@crcwm.org)
University of New Mexico Cancer Center Albuquerque, New Mexico	- (HSC-ClinicalTrialInfo@salud.unm.edu)
University of Wisconsin Carbone Cancer Center - University Hospital Madison, Wisconsin	- (clinicaltrials@cancer.wisc.edu)
VCU Community Memorial Health Center South Hill, Virginia	- (nemer.elmouallem@vcuhealth.org)
VCU Massey Cancer Center at Stony Point Richmond, Virginia	- (ctoclinops@vcu.edu)
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin	- (ncorp@aurora.org)
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan, Wisconsin	- (ncorp@aurora.org)
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers, Wisconsin	- (ncorp@aurora.org)
Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia	- (CTOclinops@vcu.edu)
Wake Forest NCORP Research Base Winston-Salem, North Carolina	Glenn Lesser, MD - (ncorp@wakehealth.edu) Beth Reboussin, PhD - (ncorp@wakehealth.edu)
Wake Forest University Health Sciences Winston-Salem, North Carolina
Wake Forest University at Clemmons Clemmons, North Carolina
WellSpan Medical Oncology and Hematology Hanover, Pennsylvania
Wellspan Health - York Cancer Center York, Pennsylvania
West Michigan Cancer Center Kalamazoo, Michigan	- (crcwm-regulatory@crcwm.org)
Westfields Hospital/Cancer Center of Western Wisconsin New Richmond, Wisconsin	- (mmcorc@healthpartners.com)
Wilcox Memorial Hospital and Kauai Medical Clinic Lihue, Hawaii
William E Kahlert Regional Cancer Center/Sinai Hospital Westminster, Maryland
Winter Haven Hospital Winter Haven, Florida	- (Research.CTO@baycare.org)
Woodland Cancer Care Center Michigan City, Indiana	- (sally.arnett@franciscanalliance.org)
Woodland Memorial Hospital Woodland, California	- (ResearchInstituteInquiries@CommonSpirit.org)

The Vanguard Study: Testing a New Way to Screen for Cancer

Contact(s):

ctrrecruit@vcu.edu

Principal Investigator:

System ID: NCT06995898

Show full eligibility criteria

Interventions: PROCEDURE: Biospecimen Collection, DEVICE: Device Usage, OTHER: Electronic Health Record Review, PROCEDURE: Multi-Cancer Detection Test, PROCEDURE: Multi-Cancer Detection Test, OTHER: Questionnaire Administration

Conditions: Bladder Carcinoma, Breast Carcinoma, Colorectal Carcinoma, Esophageal Carcinoma, Gastric Carcinoma, Liver Carcinoma, Lung Carcinoma, Malignant Solid Neoplasm, Ovarian Carcinoma, Pancreatic Carcinoma, Prostate Carcinoma

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Show 37 locations

Study Locations

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Location	Contacts
Cancer Care and Hematology-Fort Collins Fort Collins, Colorado	Site Public Contact - (ctsucontact@westat.com)
Henry Ford Cancer Institute-Downriver Brownstown, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Health Center - Brownstown Brownstown, Michigan	Site Public Contact - (CDUDAS1@hfhs.org)
Henry Ford Health Center - Chesterfield Chesterfield, Michigan	Site Public Contact - (CDUDAS1@hfhs.org)
Henry Ford Hospital Detroit, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Medical Center Sterling Heights, Michigan	Site Public Contact - (ctsucontact@westat.com)
Henry Ford Medical Center - Detroit Northwest Detroit, Michigan	Site Public Contact - (kkeenan1@hfhs.org)
Henry Ford Medical Center - Livonia Livonia, Michigan	Site Public Contact - (kkeenan1@hfhs.org)
Henry Ford Medical Center - Plymouth Plymouth, Michigan	Site Public Contact - (kkeenan1@hfhs.org)
Henry Ford Medical Center - Royal Oak Royal Oak, Michigan	Site Public Contact - (kkeenan1@hfhs.org)
Henry Ford Medical Center - Troy Troy, Michigan	Site Public Contact - (kkeenan1@hfhs.org)
Henry Ford Medical Center-Columbus Novi, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Medical Center-Cottage Grosse Pointe Farms, Michigan
Henry Ford Medical Center-Fairlane Dearborn, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford West Bloomfield Hospital West Bloomfield, Michigan	Site Public Contact - (CTOResearch@hfhs.org)
Henry Ford Wyandotte Hospital Wyandotte, Michigan	Site Public Contact - (nhay@hfhs.org)
Inova Fair Oaks Hospital Fairfax, Virginia	Site Public Contact - (Stephanie.VanBebber@inova.org)
Inova Schar Cancer Institute Fairfax, Virginia	Site Public Contact - (Stephanie.VanBebber@inova.org)
Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii	Site Public Contact - (shelley.a.clark@kp.org)
Kaiser Permanente-Division of Research Pleasanton, California
Kaiser Permanente-Franklin Denver, Colorado	Site Public Contact - (KPCOIHRClinicalResearch@kp.org)
Kaiser Permanente-Lone Tree Lone Tree, Colorado	Site Public Contact - (KPCOIHRClinicalResearch@kp.org)
Kaiser Permanente-Rock Creek Lafayette, Colorado	Site Public Contact - (KPCOIHRClinicalResearch@kp.org)
Keefe Memorial Hospital Cheyenne Wells, Colorado	Site Public Contact - (cmillsap@keefemh.org)
Medical Center of the Rockies Loveland, Colorado
Poudre Valley Hospital Fort Collins, Colorado
Saint Luke's Hospital of Kansas City Kansas City, Missouri	Site Public Contact - (aroland@kccop.org)
Sentara Martha Jefferson Hospital Charlottesville, Virginia
Sentara Norfolk General Hospital Norfolk, Virginia
UCHealth Greeley Hospital Greeley, Colorado	Site Public Contact - (ctsucontact@westat.com)
UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina	Site Public Contact - (cancerclinicaltrials@med.unc.edu)
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma	Site Public Contact - (ou-clinical-trials@ouhsc.edu)
VCU Community Memorial Health Center South Hill, Virginia	Site Public Contact - (nemer.elmouallem@vcuhealth.org)
VCU Massey Cancer Center at Stony Point Richmond, Virginia	Site Public Contact - (ctoclinops@vcu.edu)
VCU Massey Comprehensive Cancer Center Richmond, Virginia	Site Public Contact - (CTOclinops@vcu.edu)
Washington University School of Medicine St Louis, Missouri	Site Public Contact - (info@siteman.wustl.edu)

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