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Evaluating Urinary CXCL10 for Enhanced Detection of Acute Rejection in Kidney Transplant Patients With Low DD-CFDNA

RECRUITING
I'm interested

18 years and over
This study is NOT accepting healthy volunteers
Prospective
Inclusion Criteria:
* Age ≥18 years * Undergoing a clinically indicated biopsy * Able to provide informed consent * Willing to provide a urine sample and allow access to relevant clinical Retrospective
Inclusion Criteria:
* Age ≥18 years * Biopsy-confirmed rejection (positive histology) * Donor-derived cell-free DNA\<1% result at time of biopsy * Availability of stored urine sample collected at time of biopsy Exclusion Criteria (applies to both arms): * Individuals under 18 years of age * Individuals unable to provide informed consent (for prospective enrollment) * Pregnant women * Prisoners * Adults unable to consent

OTHER: Retrospective Cohort Enrollment, OTHER: Prospective Cohort Enrollment

Kidney Transplant Rejection

CXCL10, CXCR3+T cells, ccfDNA, dd-cfDNA, ABMR, TCMR

Amber Paulus, PhD - amber.Paulus@vcuhealth.org
NCT07415876

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