StudyFinder
Predicting Outcomes in Nonalcoholic Steatohepatitis With Advanced Fibrosis
RECRUITING
18 years and over
Inclusion Criteria:
Adult patients with presence of NAFLD associated cirrhosis.
* Cirrhosis: biopsy confirmed or Agile F (F4) score \> 0.45
* NAFLD as an etiology of liver disease will be determined based on presence of any of the following:
* Biopsy showing \>5% steatosis or
* CAP \> 280 dB/m or MR-PDFF\>5%
* If CAP \< 280 dB/m or MR-PDFF \<5%, then must have type 2 diabetes and or 2 or more features of metabolic syndrome for 5 years (cryptogenic cirrhosis)
Exclusion Criteria:
* Refusal to consent
* Alcohol use \> 14/21 gm/week cutoff
* Other causes of chronic liver disease
* MELD \> 12
* Hepatic and extrahepatic cancers expected to limit life expectancy \< 2 yrs
* prior hepatic resections, TIPS, splenic embolization
* prior decompensation events
* inability to fit into MRI (failed hula-hoop test)
* general contraindication for MRI contrast (GFR \< 30 ml/min)
* contraindications for MRI
* pregnancy
* acute kidney injury
* reduced kidney function (GFR \<30ml/min)OTHER: Standard of care
Nonalcoholic Steatohepatitis
Mohammad S Siddiqui, MD - mohammad.siddiqui@vcuhealth.org
NCT05720663
See this study on ClinicalTrials.gov