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Postprandial Monocyte Maturation and Vascular Dysfunction Following High-Fat Meals - Study 1
OPEN TO ACCRUAL
18 years to 30 years old
Inclusion Criteria:
• college-age: 18-30 years old
• normal fasting triglyceride (<150 mg/dL) (American College of Sports Medicine Guidelines for Exercise Testing and Prescription, 10th Edition).
• normal body composition: % body fat, males <25%, females <32% (American College of Sports Medicine Guidelines for Exercise Testing and Prescription, 10th Edition)
• self-reported engagement in moderate-vigorous intensity physical activity and/or an exercise training regimen OR self-reported low physical activity and no engagement in an exercise training regimen (International Physical Activity Questionnaire)
• low cardiorespiratory fitness (VO2peak; male: =<45 mL/kg/min; female: =<35 mL/kg/min; categorized as =40th percentile by ACSM Guidelines for Exercise Testing and Prescription, 10th Edition; 44, 45, 46, 47) OR high cardiorespiratory fitness (VO2peak; male: =55 mL/kg/min; female: 45 mL/kg/min; categorized as =70th percentile by ACSM Guidelines for Exercise Testing and Prescription, 10th Edition; 44, 45, 46, 47) f.) for female participants, presence of a normal, monthly menstrual cycle with or without prescribed contraceptive methods. .
Exclusion Criteria:
• presence of diagnosed cardiovascular, metabolic, or renal disease or dysfunction
• presence of signs and symptoms suggestive of cardiovascular, metabolic, or renal disease
• presence of musculoskeletal injury
• pregnancy
• history of smoking
• engagement in an abnormal eating behavior
• unable to communicate effectively in English
• moderate cardiorespiratory fitness (VO2peak; male: 46-54 mL/kg/min; female: 36-44 mL/kg/min)
• elevated or high fasting triglycerides (>150 mg/dL)
• absence of a normal, monthly menstrual cycle with or without prescribed contraceptive methods
Other: High-fat meal
Cardiovascular Risk Factor, Lipemia, Diseases of Circulatory System (390-459)
Vascular Dysfunction
Franco, Robert, "Lee" - francorl@vcu.edu
Franco, Robert, "Lee"
N/A
HM20015510
NCT03958734
See this study on ClinicalTrials.gov